LOCUS       NC_003155              10405 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7666128
            Orig. end                         :: 7676533
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="33"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5405)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            714..1721
                     /db_xref="GeneID:41543466"
                     /locus_tag="SAVERM_RS32870"
                     /old_locus_tag="SAV_6392"
                     /old_locus_tag="SAVERM_6392"
     CDS             714..1721
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41543466"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238583.1"
                     /locus_tag="SAVERM_RS32870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6392"
                     /old_locus_tag="SAVERM_6392"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_010987792.1"
                     /transl_table=11
                     /translation="MARSTSPARGVRRIAVVAASPVSMFNLAIPELLFEKVEIDGAPGY
                     EVTICAPEPGPVPTTGGLDLYVRHGLDAVRDADTVLVAGTGLRYTPDPRTVDAVREAAA
                     DGKRIASICSGAFALAEAGLLAGRRATTYWGQAEELRKRYPSVDLKGDVLYVQDGPIMT
                     SSGYAAGIDLCLHIIRTDYGAAAANRVARLALVAPVRPGGQTQFTQTPLPPERGTACAD
                     TRGWAMRHLDSPLTLTDLARHAGVSVRTLTRRFHAESGVSPLQWLLHQRIERAKELLET
                     TTLPMDQVARASGLGTADSLRGHLVRRTGLTPSAYRTQFSRLGSGPGPGMEQAA"
     gene            1784..2500
                     /db_xref="GeneID:41543467"
                     /locus_tag="SAVERM_RS32875"
                     /old_locus_tag="SAV_6393"
                     /old_locus_tag="SAVERM_6393"
     CDS             1784..2500
                     /codon_start=1
                     /db_xref="GeneID:41543467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671937.1"
                     /locus_tag="SAVERM_RS32875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6393"
                     /old_locus_tag="SAVERM_6393"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_010987793.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALEAFPHRDDVEVVHRSFELDP
                     NRAKGDIQPVLTMLTKKYGMSEAQAQAGEDNLGAQAAAEGLDYRTRDRDHGNTFDMHRL
                     LHFAKEQGRQDELIGLLYRANFAEERSVFDDDERLVELAVAAGLDAEAARTVLADPAAY
                     ADEVRADEREAAELGASGVPFFVLDRAYGVSGAQPAEVFAQALKQAWGDRPPLTLIQDS
                     GDAQACGPDGCAVPQG"
     gene            2607..3677
                     /db_xref="GeneID:41543468"
                     /locus_tag="SAVERM_RS32880"
                     /old_locus_tag="SAV_6394"
                     /old_locus_tag="SAVERM_6394"
     CDS             2607..3677
                     /NRPS_PKS="Domain: Aminotran_5 (16-343). E-value: 3.1e-24.
                     Score: 77.5. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS32880_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:41543468"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477739.1"
                     /locus_tag="SAVERM_RS32880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6394"
                     /old_locus_tag="SAVERM_6394"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_037646865.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1e-18, bitscore:
                     66.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METFEPLVRAEFAPKNTYLNTASTGLVPARTVAAMRVAVESAAAG
                     QPTDMFADVEAARASFARLTGVPVRRVAAGASVAVYSGLIAASLPEGAEVLTAEADFSS
                     VVNPFHIRRDLKVRAVPLEGLAESVRPGTALVAVSAAQSADGRVADLPAVRAAARAHGA
                     RTYIDASQATGWLQIDADAYDYVSSVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAG
                     QAPWDSCYGPVEELAHSARRFDESPALFSYAGARHSLALIEELGVENVRAHDLALADRF
                     RTGLASLGHEPVPAPHAPIVSVPGLGDRQPALSRAGVEVSDRAGNLRAAFHLYNTPADV
                     DRLLDVLSGLSGRPLA"
     aSDomain        2655..3635
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS32880_Aminotran_5.1"
                     /evalue="3.10E-24"
                     /label="SAVERM_RS32880_Aminotran_5.1"
                     /locus_tag="SAVERM_RS32880"
                     /protein_end="343"
                     /protein_start="16"
                     /score="77.5"
                     /tool="antismash"
                     /translation="TYLNTASTGLVPARTVAAMRVAVESAAAGQPTDMFADVEAARASF
                     ARLTGVPVRRVAAGASVAVYSGLIAASLPEGAEVLTAEADFSSVVNPFHIRRDLKVRAV
                     PLEGLAESVRPGTALVAVSAAQSADGRVADLPAVRAAARAHGARTYIDASQATGWLQID
                     ADAYDYVSSVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAGQAPWDSCYGPVEELAH
                     SARRFDESPALFSYAGARHSLALIEELGVENVRAHDLALADRFRTGLASLGHEPVPAPH
                     APIVSVPGLGDRQPALSRAGVEVSDRAGNLRAAFHLYNTPADVDRL"
     gene            3722..>3973
                     /db_xref="GeneID:41544905"
                     /locus_tag="SAVERM_RS40620"
                     /pseudo=""
     CDS             3722..>3973
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41544905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436208.1"
                     /locus_tag="SAVERM_RS40620"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="sigma factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MESTADTAAGPPADAELRRRLVYGDESALGEAYAAYGALVRRVAR
                     RVTRSPAAAEDVAQEVFAQLWSRPYAFDARRGSLRTWLS"
     gene            complement(4108..4995)
                     /db_xref="GeneID:41543469"
                     /gene="thpD"
                     /locus_tag="SAVERM_RS32885"
                     /old_locus_tag="SAV_6395"
                     /old_locus_tag="SAVERM_6395"
     CDS             complement(4108..4995)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /db_xref="GeneID:41543469"
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976953.1"
                     /locus_tag="SAVERM_RS32885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6395"
                     /old_locus_tag="SAVERM_6395"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_037646868.1"
                     /sec_met_domain="PhyH (E-value: 5.8e-38, bitscore: 130.1,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTITDLYPSRGAAEVSVPRQDPVLWGTPDTPGPITAADLQSYEH
                     DGFLAVPQLIGDDEVALYHAELERLIHDPAVRADERSIVEPQSQEIRSVFEVHKISEIF
                     AQLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNMRT
                     VSVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGTPSDEALTKF
                     ADRHGIRLFTGRAGSATWFDCNCLHGSGDNITPFPRSNVFIVFNSVENTAVEPFSAPVR
                     RPEFIGARDFTPVR"
     gene            complement(5001..5405)
                     /db_xref="GeneID:41543470"
                     /locus_tag="SAVERM_RS32890"
                     /old_locus_tag="SAV_6396"
                     /old_locus_tag="SAVERM_6396"
     CDS             complement(5001..5405)
                     /codon_start=1
                     /db_xref="GeneID:41543470"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643612.1"
                     /locus_tag="SAVERM_RS32890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6396"
                     /old_locus_tag="SAVERM_6396"
                     /product="ectoine synthase"
                     /protein_id="WP_010987796.1"
                     /sec_met_domain="ectoine_synt (E-value: 5.1e-54, bitscore:
                     180.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKAASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCVEGEAELTDDETGEKHWITPGTMYLLDGHERHTMRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEPEEV"
     gene            complement(5463..6734)
                     /db_xref="GeneID:41543471"
                     /gene="ectB"
                     /locus_tag="SAVERM_RS32895"
                     /old_locus_tag="SAV_6397"
                     /old_locus_tag="SAVERM_6397"
     CDS             complement(5463..6734)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-367). E-value: 2.1e-74.
                     Score: 242.5. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS32895_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GeneID:41543471"
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="SAVERM_RS32895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6397"
                     /old_locus_tag="SAVERM_6397"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_010987797.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-78, bitscore:
                     262.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRAQGSRMYDEDGHAY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTAAKRAFLESFQNLILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGKVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALAELCKRQDMLLIVDDIQMGCGRTGAFFSFEEAGVTPDIVTVSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALQTYWADGSAMEKQTLARGEQVEQAL
                     ISITEENLADVKEYRGRGLVWGIEFKDKDRAGRIAQRAFELGLLIETSGPESEVVKLLP
                     ALTITPEELDEGLRTLARAVRETA"
     aSDomain        complement(5634..6650)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS32895_Aminotran_3.1"
                     /evalue="2.10E-74"
                     /label="SAVERM_RS32895_Aminotran_3.1"
                     /locus_tag="SAVERM_RS32895"
                     /protein_end="367"
                     /protein_start="28"
                     /score="242.5"
                     /tool="antismash"
                     /translation="FDRAQGSRMYDEDGHAYLDFFAGAGSLNYGHNNPVLKRALIDYLE
                     RDGVTHGLDMSTAAKRAFLESFQNLILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGKVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALAELCKRQDMLLIVDDIQMGCGR
                     TGAFFSFEEAGVTPDIVTVSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALQTYWADGSAMEKQTLARGEQVEQALISITEENLADVKEYRGRGLVWGIEFKD"
     gene            complement(6764..7303)
                     /db_xref="GeneID:41543472"
                     /gene="ectA"
                     /locus_tag="SAVERM_RS32900"
                     /old_locus_tag="SAV_6398"
                     /old_locus_tag="SAVERM_6398"
     CDS             complement(6764..7303)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41543472"
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987798.1"
                     /locus_tag="SAVERM_RS32900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6398"
                     /old_locus_tag="SAVERM_6398"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_010987798.1"
                     /transl_table=11
                     /translation="MTAAHADLQAEFLEMPEGLRIDRPDVADGSALWRIAKDSKTLDLN
                     SSYSYLLWCRDFAGTTAVARAADGTPVGFITAYVRPERPHTLLVWQVAVDAAYRGRGLA
                     ARMLDGLTARVTDEYGVTGIETTISPGNTASERLFTSYAQRHGADLEREVLFEAGLFPD
                     APHDPEVLYRIGPLSH"
     misc_feature    complement(7328..7340)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(7424..7438)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.29"
                     /tool="antismash"
     misc_feature    7425..7439
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.97"
                     /tool="antismash"
     misc_feature    complement(7459..7474)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    7532..7544
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            complement(7669..8790)
                     /db_xref="GeneID:41543473"
                     /locus_tag="SAVERM_RS32905"
                     /old_locus_tag="SAV_6399"
                     /old_locus_tag="SAVERM_6399"
     CDS             complement(7669..8790)
                     /NRPS_PKS="Domain: Aminotran_5 (80-301). E-value: 5.9e-28.
                     Score: 89.7. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS32905_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:41543473"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018533391.1"
                     /locus_tag="SAVERM_RS32905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6399"
                     /old_locus_tag="SAVERM_6399"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_242432298.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.1e-20, bitscore:
                     72.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEESIAVTHPFLDLAPLSAAHFASIEDRVARLLATEQDVVIMQG
                     EALLPLEGAIRAAAGPGTTALNVITGPYGQTFGNWLRDCGATVIDLAVPFHTAVTAARI
                     REAFAAHPEIDFVSLVHAEAATGNTNPVAEIGAAVREHGALFYLDAVASIGAEPVLPDA
                     WGVDLCVIGAQKAMGGPAGVSAVSVSERAWARMAANPAAPRRSYLSLLDWKERWVDGGR
                     KALLHAPAQLEMLALEACVERIEAEGLEAVMARHASAAAATRAGAVALGGGLEPYVHEA
                     ADAAPVATTLRTPAGIDASELVAKALASDPVLPLVAGGGALAREMVRVNHYGPGATRGV
                     VQSCLGALGAALAEFGVPVDLEGARRAVAEAWA"
     aSDomain        complement(7888..8550)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS32905_Aminotran_5.1"
                     /evalue="5.90E-28"
                     /label="SAVERM_RS32905_Aminotran_5.1"
                     /locus_tag="SAVERM_RS32905"
                     /protein_end="301"
                     /protein_start="80"
                     /score="89.7"
                     /tool="antismash"
                     /translation="LRDCGATVIDLAVPFHTAVTAARIREAFAAHPEIDFVSLVHAEAA
                     TGNTNPVAEIGAAVREHGALFYLDAVASIGAEPVLPDAWGVDLCVIGAQKAMGGPAGVS
                     AVSVSERAWARMAANPAAPRRSYLSLLDWKERWVDGGRKALLHAPAQLEMLALEACVER
                     IEAEGLEAVMARHASAAAATRAGAVALGGGLEPYVHEAADAAPVATTLRTPAGIDASE"
     gene            8989..9837
                     /db_xref="GeneID:41543474"
                     /locus_tag="SAVERM_RS32910"
                     /old_locus_tag="SAV_6400"
                     /old_locus_tag="SAVERM_6400"
     CDS             8989..9837
                     /codon_start=1
                     /db_xref="GeneID:41543474"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121392.1"
                     /locus_tag="SAVERM_RS32910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_6400"
                     /old_locus_tag="SAVERM_6400"
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_010987800.1"
                     /transl_table=11
                     /translation="MKTVLGRRSRILAATTATAGLLLVAGCSSDNGGGKTTVKGVPLVK
                     AGQITTCTHLPYPPFQSEIDGKVQGFDVSLIDLVAKDLGVKQAIVDTPFENFKTGAFLN
                     SGQCDVAAAGMTITEERKKNVDFSDPYFEATQAVLVDKKSGVDSLADVKAKGKKLGAQA
                     QTTGEEYAKSKGFDAVSFESSDAVLNGLRTGQVQAVIIDYPVVQGWLKDKANADAFKVV
                     DNLNTGEEYGFTVKKGNTKLLAEINKTIKQAKADGTYKKIYEKWIGPYTASAATASPSA
                     S"
     misc_feature    10192..10206
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
     misc_feature    complement(10306..10320)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
ORIGIN
        1 cgcgggccgg cgctccgagc gcggcgcccg cagcaggagg acgagcgcca gcgcacccag
       61 gggcaggttg atgaagaaga tgccccgcca gtcccacgcc gtcgtcagcg cgccgcccgc
      121 caccggaccc agcgccaccg ccaccgagcc gcccgccgcc cacagcgcca ccgctcgcgc
      181 ccggcgtgcc gcgtccgggt acgcctgccg caccagcgcc agcgaggccg gcagcaccac
      241 ggccgccgcc accccctgcg ccacccgggc gccgatcagc accggcaggc cgggcgcgag
      301 cccgcacgcc gccgaggcca gggtgaacac ggcgatcccg atcccgtagg cccggctcgc
      361 cccggcccgg tccgcgaacg ctccggtgga cagcatcagc gccgcgaagg cgagggtgta
      421 cgcgtccacg acccactgga gcccggacat cccgcccccg aacgccgagc cgatcgacgg
      481 aagggccacg ttcacgacgg acgcgtcgag ggtgatcagc gcgaagccga ggagtgcggc
      541 ggcgagggtg agcgagggag aggtgtggtg ctccaactcg cttgtggcag aggtgagtcg
      601 ggggtccgtc gggggagttt ccgtggtcgg gttcgtagcc atgccctcca tgctgctgat
      661 ctccggcggc gtacagtagt ggccggaatg acatatgacc ggaggttctg gccatggccc
      721 gatccacgtc cccggcccgg ggtgtccgcc ggatcgccgt cgtcgcggcg tcccccgtct
      781 cgatgttcaa cctcgccatc cccgagctgc tgttcgagaa ggtcgagatc gacggcgctc
      841 cgggctacga ggtgaccatc tgcgccccgg agccgggccc ggtgcccacc accggcggcc
      901 tcgacctgta cgtccggcac gggctcgacg ccgtacggga cgcggacacg gtgctcgtcg
      961 cgggcaccgg gctgcgctac acgcccgacc cgcgcacggt ggacgccgtc cgcgaggccg
     1021 ccgccgacgg caagcggatc gcgtccatct gcagcggcgc cttcgcactc gccgaggcgg
     1081 ggctgctcgc gggccgccgg gccaccacct actggggaca ggccgaggaa ctgcgcaagc
     1141 ggtacccgtc cgtcgacctc aagggcgatg tcctgtacgt gcaggacggc ccgatcatga
     1201 cctcctccgg gtacgccgcc ggaatcgacc tgtgcctcca catcatccgc accgactacg
     1261 gcgccgccgc cgcgaaccgg gtggcccggc tcgccctcgt cgcgcccgtg cgccccggcg
     1321 gccagaccca gttcacccag accccgctgc cgcccgagcg cggcaccgcc tgcgccgaca
     1381 cccgcggctg ggccatgcgt cacctcgaca gtccgctcac gctcaccgac ctggcccggc
     1441 acgcgggcgt cagcgtgcgt accctcaccc ggcgcttcca cgcggagagc ggggtcagcc
     1501 cccttcagtg gctgctccac cagcgcatcg agcgggccaa ggaactcctg gagacgacca
     1561 cgctcccgat ggaccaggtg gcccgcgcct cgggcctggg caccgccgac tcgctccgcg
     1621 gccatctggt gcgccgcacg ggactgaccc cgagcgccta ccgcacccag ttcagccgcc
     1681 tgggaagcgg accgggaccg ggaatggaac aagccgcttg aacgttcacg caagcggcgg
     1741 agggaggctc cgtcaccctt ccgacctgga gagaagccga agaatgcgcg tcgagatctg
     1801 gagcgacatc gcctgcccct ggtgctacgt gggcaaggcc cgcttcgaga aggcgctcga
     1861 agcctttccg caccgcgacg acgtcgaggt ggtgcaccgc tccttcgagc tcgacccgaa
     1921 ccgcgccaag ggcgacatcc agcccgtcct cacgatgctg accaagaagt acggcatgag
     1981 cgaggcgcag gcccaggccg gcgaggacaa cctgggcgcg caggccgccg ccgagggact
     2041 ggactaccgc acccgggacc gcgaccacgg caacaccttc gacatgcacc gcctgctgca
     2101 cttcgccaag gagcagggca ggcaggacga gctgatcggg ctcctgtacc gggcgaactt
     2161 cgccgaggag cgctccgtct tcgacgacga cgagcggctc gtcgagctgg ccgtcgccgc
     2221 cggtctcgac gcggaggccg cccgcacggt cctcgccgac ccggccgcgt acgccgacga
     2281 ggtccgcgcc gacgagcggg aggccgcgga gctgggggcg agcggtgtcc ccttcttcgt
     2341 cctcgaccgc gcctacggtg tctccggcgc ccagcccgca gaggtcttcg cccaggccct
     2401 gaagcaggcg tggggggacc ggccgccgct cacgctcatc caggacagtg gtgacgccca
     2461 ggcgtgcggt cccgacggct gcgccgtgcc gcagggctga ggaccccggg aaaccgcagg
     2521 tcggagcgga cctgtaagcg atccttgggg gaaccacgta aaactccgca atggacgggg
     2581 ggttcgcggg gccgcagagt ggtcccatgg agaccttcga gcccctcgtc cgtgccgagt
     2641 tcgccccgaa gaacacctac ctgaacaccg cgagcaccgg cctcgtaccg gcccgcacag
     2701 tggcggccat gcgcgtcgcc gtggagtcgg ccgccgccgg gcagccgacc gacatgttcg
     2761 cggacgtcga ggcggcacgc gcctccttcg cccggctgac cggggtaccc gtccgccggg
     2821 tggcggccgg ggcctcggtc gcggtctaca gcgggctgat cgccgcctcg ctgccggagg
     2881 gcgccgaagt cctcaccgcc gaggccgact tcagctccgt cgtgaacccc ttccacatcc
     2941 gccgcgacct caaggtgcgc gccgtcccgc tggagggcct cgccgagtcg gtgcgccccg
     3001 gcacggcgct cgtcgcggtc agcgccgccc agtccgccga cggccgggtc gccgacctgc
     3061 cggccgtccg cgcggccgcc cgcgcgcacg gcgcccgtac gtacatcgac gcatcccagg
     3121 ccaccggctg gctgcagatc gacgcggacg cctacgacta cgtctcctcc gtcgccttca
     3181 agtggctcgt ctgtccgcgc ggcgtggcct tcctggtcgt cccggaggac ctcggcggcc
     3241 tcaccccgct gttcgccggc tgggtcgcgg gacaggcgcc gtgggacagc tgttacgggc
     3301 ccgtcgagga actcgcccac tccgcacggc ggttcgacga gagccccgcc ctcttctcgt
     3361 acgcgggcgc ccgccactcc ctcgcgctga tcgaggaact gggcgtggag aacgtacggg
     3421 cccatgacct cgcactcgcc gaccgcttcc gtaccggcct cgcgtccctc ggccacgaac
     3481 cggtccccgc accacacgcg ccgatcgtgt ccgtgcccgg cctcggcgac cggcagccgg
     3541 ccctcagccg cgccggagtc gaagtctccg accgcgcggg caacctgagg gcggccttcc
     3601 acctctacaa cacgcccgcc gacgtcgacc ggctccttga tgtcctgtcg ggcctgtccg
     3661 gccgccccct ggcgtagcgc ccccggggac gccaggaagg caccacgagg cggtggtgcc
     3721 cgtggagtcg acggccgaca cagccgcagg accgcccgcc gacgcggaac tgcgtcggcg
     3781 gctggtgtac ggggacgagt ccgcgctggg cgaggcgtac gccgcgtacg gggcgctcgt
     3841 ccggcgggtg gcccggcgcg tcacccgcag cccggccgcc gccgaggacg tggcgcagga
     3901 ggtcttcgcc cagctgtgga gcaggccgta cgcgttcgac gcgcgccgcg gctcgctgcg
     3961 cacctggctg tccgggggac acgggagccg cggccggcgt actggcgcgg gcggcttcgc
     4021 tgggctggct gtagagcctg gctgcagaca cagcacggcc cgggttctcc cgccccatgg
     4081 gagaacccgg gccgtgccgg gcggcggtca ccgcaccggc gtgaagtccc gcgccccgat
     4141 gaactccgga cgccgtaccg gcgccgagaa cggctccacc gccgtgttct ccacgctgtt
     4201 gaacacgatg aacacattgc tgcgcgggaa gggtgtgatg ttgtccccgg agccgtgcag
     4261 gcagttgcag tcgaaccagg tcgccgaacc ggcccggccc gtgaagagcc ggatgccgtg
     4321 ccggtccgcg aacttggtca gcgcctcgtc ggagggcgtg cccgcgtcct gcatctggag
     4381 cgacttcttg tagttgtcct tcggggtggc cccggcacac ccgaggaacg tcttgtgcga
     4441 ccccggcatg atcatgaggc cgccgttggt gtcgtagttc tcggtcagcg cgatcgagac
     4501 ggacaccgtg cgcatgttgg gcaggccgtc ctcggcgtgc caggtctcga agtccgagtg
     4561 ccagtagaag ccgctggccc cgaagccggg cttgacgttg atccgggact ggtggacgta
     4621 cacgtccgag ccgaggatct gccgtgcccg ccccaccacg cgctcgtcgc gcacgagctg
     4681 ggcgaagatc tcgctgatct tgtgcacctc gaagaccgac cggatctcct gcgactgcgg
     4741 ttccacgatg gagcgctcgt cggcgcgcac cgcggggtcg tggatcaggc gttccaactc
     4801 ggcgtggtag agcgcgactt cgtcatcacc gatgagctgc gggacggcga ggaagccgtc
     4861 gtgctcgtac gactggaggt cggccgccgt gatggggccc ggtgtgtccg gcgtgcccca
     4921 caggaccggg tcctggcggg ggaccgacac ctcggcggcg ccgcggctcg ggtacaggtc
     4981 ggtgatcgtg gtcatggggc tcagacctcc tcgggttcgg tcagcagcgg gtagacgccg
     5041 ttctcgtcgt ggtcctcccg tccggtgacg ggagggttga agacgcagac gcaccggaag
     5101 tcggtcttgg ggcgcatggt gtggcgctcg tggccgtcca gcaggtacat cgtccccggc
     5161 gtgatccagt gcttctcgcc ggtctcgtca tcggtcagtt cggcctcgcc ctccacgcag
     5221 agcacggcct cgatgtggtt cgcgtaccac atcgacgtct cggtacccgc gtacaggacg
     5281 gtctcgtgca gcgagaagcc gaccttctcc ttggcgagga cgatgcgctt gctctcccag
     5341 gtgccggacg cggccttcac atgccggtcg gtgccttcga tgtccttgaa cgaacggact
     5401 atcacggtgg tgcgatgcct ctctctcgtg ctctcgggtg tggtgcgggt ctctggtgcc
     5461 ggtcaggcgg tttcccgtac ggcgcgggcg agggtacgca gcccctcgtc gagctcctcg
     5521 ggcgtgatcg tcagggccgg aagcagcttg acgacctcgc tctccgggcc cgacgtctcg
     5581 atgagcagcc cgagctcgaa ggcgcgctgt gcgatgcgcc cggcgcggtc cttgtccttg
     5641 aactcgatgc cccagacgag gccccgcccg cggtactcct tgacgtcggc gaggttctcc
     5701 tcggtgatgg agatcagcgc ctgctcgacc tgctcaccgc gggcgagggt ctgcttctcc
     5761 atggcggatc cgtcggccca gtacgtctgg agggccgcgg cggccgtgac gaacgcgggg
     5821 ttgttgccgc ggaacgtgcc gttgtgctcg cccggctccc agatgtccag ctcgggcttg
     5881 aacaggcaca gggacatggg gagcccgtac ccgctgatgg acttggaaac cgtgacgatg
     5941 tccggtgtga cgcccgcctc ctcgaaggag aagaacgcgc ccgtacggcc gcagcccatc
     6001 tggatgtcgt cgacgatgag cagcatgtcc tgccgcttgc acagctcggc cagggcgcgc
     6061 agccactcgg gacgcgcgac gttgatgccg ccctcgccct gcacggtctc gacgatcacg
     6121 gccgcgggct tgttgaggcc ggagccctgg tcctccagga gccgctcgaa ccagaggaag
     6181 tccgggacct tgccgtcgaa gtagttgtcg aacggcatgg gcgtgccgtg cacgaggggt
     6241 atcccggcgc cggcgcgctt gaaggcgttg ccggtcacgg cgagcgagcc cagcgacatg
     6301 ccgtggaagg cgttggtgaa ggacacgatg gcctcgcgcc ccttcacctt ccgcgccagc
     6361 ttgagcgcgg actccacggc gttggtgccc gtcgggcccg ggaacatgac cttgtacggc
     6421 aggtcacgcg ggcgcaggat caggttctgg aaggactcca ggaaggcgcg cttggcggcc
     6481 gtcgacatgt cgagcccgtg cgtgacgccg tcccgctcca gatagtcgat caacgcccgt
     6541 ttgagtacgg ggttgttgtg gccgtagttg agtgagccgg cgccggcgaa gaagtccagg
     6601 tacgcgtggc cgtcctcgtc gtacatgcgg ctgccctgcg cccggtcgaa gacggtgggc
     6661 cagccgcggc agtagctgcg cacctccgac tcgacggtct cgaagacgct caggtcgggc
     6721 tgggtgatgg tcacggcgaa atcgctcctc ggtgcgtggg gggtcagtgg gagagggggc
     6781 cgatgcggta caggacctcg gggtcgtgcg gggcgtcggg gaacagccct gcctcgaaca
     6841 ggacctcacg ctcgaggtcc gcgccgtggc gctgcgcata cgaggtgaac aggcgttcgg
     6901 aggcggtgtt gccgggggag atcgtcgtct cgatgccggt caccccgtac tcgtccgtga
     6961 cgcgtgcggt cagtccgtcg agcatgcgcg cggccagccc gcgcccgcgg tacgccgcgt
     7021 cgacggccac ctgccagacg aggagggtgt gcgggcgctc gggccgcacg tacgcggtga
     7081 tgaagccgac gggcgtcccg tcggcggctc gtgccaccgc cgtggtgccg gcgaagtcac
     7141 ggcaccacag cagatagctg tacgaggagt tcaggtcgag ggtcttggag tccttggcga
     7201 tgcgccagag tgcggacccg tccgccacgt ccgggcggtc gatccgcagt ccctcgggca
     7261 tttccaggaa ttccgcttgc aggtctgcgt gtgcggcggt catgccgact gaatttaccg
     7321 agggaaattc gaaattgcat cgtcggatgg ggttacgaaa tgagccgtca tgtgttatca
     7381 cgcgggcgcg ggtgatcgcg caagacggcg tcgataaccc ccattttgtc cggaaaatac
     7441 gggaggaaag gggtgcgatg tggagtcgat cacaagtgga cgacccgtgc gggacctgcc
     7501 cgaattaagc cggttggtgt tcgcgaaatc tttgcgttta gcacgaaaga aagcgggcag
     7561 aagaatgcgg gaagctgttc tgaattaata acgggataag tgtgtgggga atctctgcaa
     7621 ttcacggcga gaagcgatgg aaagtgccgg gggaagtggc gggaggggtc aggcccaggc
     7681 ctcggccacc gcgcgccggg ccccctccag gtccaccggc acgccgaact cggccagcgc
     7741 ggcccccagc gcacccaggc aggactgcac cacaccccgc gtcgcgccgg gtccgtagtg
     7801 gttgacccgg accatctcgc gggcgagcgc gcccccgccc gcgacgagcg gcagcaccgg
     7861 atccgaggcc agcgccttgg cgaccagctc cgaggcgtcg atcccggccg gcgtccgcag
     7921 cgtcgtggcg acgggcgccg cgtccgcggc ctcgtgcaca tacggttcga gcccgccacc
     7981 cagggcgacc gccccggccc gcgtggccgc cgcggccgag gcgtgccggg ccatcacggc
     8041 ctccagcccc tcggcctcga tccgctccac gcacgcctcg agcgccagca tctccagctg
     8101 cgccggcgcg tgcagcagcg ccttgcggcc gccgtcgacc caccgctcct tccagtccag
     8161 gagcgacagg tacgaccgcc ggggcgccgc cgggttggcc gccatccgcg cccacgcccg
     8221 ctcgctcacc gacaccgccg acaccccggc cggcccgccc atcgccttct gcgccccgat
     8281 cacgcacagg tcgacgcccc acgcgtccgg cagcaccggc tcggcgccga tcgacgcgac
     8341 ggcgtccaga tagaacagcg caccgtgctc ccgtacggcc gcgccgatct ccgcgaccgg
     8401 attcgtgttg cccgtggccg cctccgcgtg caccagcgac acgaagtcga tctccgggtg
     8461 cgccgcgaac gcctcccgga tccgcgcggc cgtcaccgcc gtgtggaacg gcacggccag
     8521 atcgatcacc gtcgcgccgc agtcccgcag ccagttcccg aaggtctggc cgtaggggcc
     8581 ggtgatgacg ttgagcgcgg tcgtgccggg gcccgcggcc gcgcgaatgg caccctccag
     8641 cgggagcagc gcctcgccct gcatgatcac gacgtcctgc tcggtggcga gcagccgggc
     8701 cacccggtcc tcgatcgagg cgaagtgcgc ggcgctcagg ggtgccaggt ccaggaaggg
     8761 gtgggtcacg gcgatgctct cttcgctcac gggttccatt acgcgagatc gagggtatcc
     8821 gccgggtgct ccgccgatcc cgccgccgcg gcctcggtca tacggtccgg atgccctgcc
     8881 gaggcaggac atctgaggcc atacggccca acagccatgg gattgatttg agtgagtcaa
     8941 acctttcctt ataatcggaa cccacagttc cctcatagga ggtcccccgt gaagacggtc
     9001 ctcggacgcc ggtcccgcat tctggccgcc accaccgcga cggccgggct gctgctcgtg
     9061 gccggctgct cctcggacaa cgggggaggc aagaccaccg tgaagggcgt cccgctcgtc
     9121 aaggcggggc agatcaccac ctgtacccac ctcccgtacc cgccgttcca gtcggagatc
     9181 gacggcaagg tgcagggctt cgacgtgtcg ctcatcgacc tggtcgccaa ggacctcggc
     9241 gtgaagcagg ccatcgtcga cacgcccttc gagaacttca agacgggcgc cttcctcaac
     9301 tccggccagt gcgacgtcgc cgcggccggc atgaccatca ccgaggagcg caagaagaac
     9361 gtcgacttct ccgacccgta cttcgaggcc acccaggccg tgctggtcga caagaagagc
     9421 ggcgtcgact ccctcgccga cgtgaaggcc aagggcaaga agctcggcgc ccaggcgcag
     9481 accaccggcg aggagtacgc gaagagcaag ggcttcgacg cggtctcctt cgagtcctcc
     9541 gacgcggtcc tcaacggcct gcgcaccggc caggtccagg ccgtcatcat cgactacccg
     9601 gtggtccagg gctggctgaa ggacaaggcc aacgccgacg ccttcaaggt cgtcgacaac
     9661 ctcaacaccg gtgaggagta cggcttcacg gtgaagaagg gcaacaccaa gctcctcgcc
     9721 gagatcaaca aaacaatcaa gcaggcgaag gccgacggca cgtacaagaa gatctacgag
     9781 aagtggatcg gcccgtacac cgcgtccgcg gccaccgcct ccccgtccgc ctcatgagtg
     9841 atgccgacgc acagctccag ccccgcaggt ccggtctgag cagacggcag aagcgtgccg
     9901 tctcgcgcgg cgtgcagtac gtcgtcttcg tcgcggccgt catcgccttc gcggtgctgg
     9961 ccgactgggg acagctgaag aaccagttcg cgcagtggga cctggtcaag cagatgttcc
    10021 cggacgtcat cacactggcg ctgaagaaca ccgtgctcta cacgatgtcc ggcttcgtcg
    10081 tcggactcgt actcggcatg gtcatcgccc tgatgcggct gtcctcggtg ggcccctacc
    10141 gctggctcgc cggcatctac atcgagatct tccgcggcct gcccgccctg ctgatcttcg
    10201 tcttcgtggg cgtcgccgtg ccgctggcgt tcccgggtac ggagatcccc ggcggcacct
    10261 acggcaaggt ggcactcgcg ctcggcctgg tctcggccgc ctacatggcc gagacgatcc
    10321 gcgcgggcat ccaggcggtg cccaagggac agatggaggc cgcccgttca ctgggcttct
    10381 cgcacgcgcg ggccatggtc tcgat
//
