LOCUS       NC_003155              22172 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6900819
            Orig. end                         :: 6922991
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22172
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="32"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..22172
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22172
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12172](-)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12172)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     gene            complement(182..430)
                     /db_xref="GeneID:41542796"
                     /locus_tag="SAVERM_RS29450"
                     /old_locus_tag="SAV_5708"
                     /old_locus_tag="SAVERM_5708"
     CDS             complement(182..430)
                     /codon_start=1
                     /db_xref="GeneID:41542796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009309419.1"
                     /locus_tag="SAVERM_RS29450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5708"
                     /old_locus_tag="SAVERM_5708"
                     /product="hypothetical protein"
                     /protein_id="WP_010987110.1"
                     /transl_table=11
                     /translation="MSESPSSGPVGVILSVDPDRFAEVVEAARGAGLTVTGEQAILGTL
                     SGTIAEDRIPALKAVAGIESVDRDRTVHLPPPDAPIQ"
     gene            complement(427..1761)
                     /db_xref="GeneID:41542797"
                     /locus_tag="SAVERM_RS29455"
                     /old_locus_tag="SAV_5709"
                     /old_locus_tag="SAVERM_5709"
     CDS             complement(427..1761)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542797"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717251.1"
                     /locus_tag="SAVERM_RS29455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5709"
                     /old_locus_tag="SAVERM_5709"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_010987111.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.6e-50, bitscore:
                     170.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANGPMDRRAFGEQPDRPDAPFTGRGAEYTGRYVILLDQSNQESG
                     LEALRASADIAPVERIRGTDAANVAELLERPDVSVLFEELGAAVVEVRPDQRHALVTTA
                     EAEPSIIAAEPERMVYASVITAPQQAPTAFFPAYRSDEGVVERHTKAEIAAAQGPAWDE
                     RNWTWGLQAIRANMSSLTGRGVKIAVLDTGVDTDHPDLAGRIDETVSFVPGETVEDGHG
                     HGTHCIGTAAGPASPQQGPRYGVASEARVLAAKVLSNAGSGTDGQILAAMAWAVAHGAR
                     VISMSLGAAVQPGELFPQTYEQLAQRALQRGTVIVAAAGNESSRPQAIRPVGRPANCPS
                     ILAVASLDRALTVSSFSSAGINGQGGEVNIAAPGRAVHSAAPGGGYQSMSGTSMATPHV
                     AGVLALLAQAAPNASAEDLKASLLSSAFPLTQPVRDVGSGLLQAP"
     gene            complement(1995..2627)
                     /db_xref="GeneID:41542798"
                     /locus_tag="SAVERM_RS29460"
                     /old_locus_tag="SAV_5710"
                     /old_locus_tag="SAVERM_5710"
     CDS             complement(1995..2627)
                     /codon_start=1
                     /db_xref="GeneID:41542798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146337.1"
                     /locus_tag="SAVERM_RS29460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5710"
                     /old_locus_tag="SAVERM_5710"
                     /product="phosphoribosyltransferase"
                     /protein_id="WP_010987112.1"
                     /transl_table=11
                     /translation="MRFRDRRQAGRELAAELLRRAEKGELTDPLVLALPRGGVPVAAEI
                     AHALKAPLDVLVVRKIGAPGRPESGIGAVAGDDPPFFDKSSLAVLGLTEAQLTQAVADQ
                     RAEVHRREERYRAGRPAPRIRGRTVILVDDGLATGVTARAALRHLRGQGAAGLILAVPV
                     GSRAVETLHEEADDVICLYEPELFYAVGEWYEDFEQLSDDEVIDTLR"
     gene            2973..3854
                     /db_xref="GeneID:41542799"
                     /locus_tag="SAVERM_RS29465"
                     /old_locus_tag="SAV_5711"
                     /old_locus_tag="SAVERM_5711"
     CDS             2973..3854
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-274). E-value:
                     1.9e-21. Score: 68.7. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS29465_Abhydrolase_1.1"
                     /codon_start=1
                     /db_xref="GeneID:41542799"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006376257.1"
                     /locus_tag="SAVERM_RS29465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5711"
                     /old_locus_tag="SAVERM_5711"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_037645495.1"
                     /sec_met_domain="PF00561 (E-value: 8.7e-17, bitscore: 60.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1e-08, bitscore:
                     34.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDQVRTTDGRLLKVEISGDPRGRPVFLLHGMPGSRVGPRPRPMF
                     LYQRGARLISYDRPGYGGSDRKAGRRVADVVQDVAEVADALELDRFAVAGRSGGAPHAL
                     ACAALLPDRVTRAAALVTLAPRDAKGLDWFAGMAPSNVHEFRTAFNDPERFVARLIPRS
                     AKIRSNPARLLEELRGDLTADDRQIVADGAIRSMLLRNYHEALRSSPYGWVDDALALTG
                     PWGFDPADIRVPVLLWHGAQDVFSPAAHSTWLAGRIPRATAVLEPAAAHFAALRALPAV
                     LTWLLADAARQG"
     aSDomain        3045..3794
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS29465_Abhydrolase_1.1"
                     /evalue="1.90E-21"
                     /label="SAVERM_RS29465_Abhydrolase_1.1"
                     /locus_tag="SAVERM_RS29465"
                     /protein_end="274"
                     /protein_start="24"
                     /score="68.7"
                     /tool="antismash"
                     /translation="PVFLLHGMPGSRVGPRPRPMFLYQRGARLISYDRPGYGGSDRKAG
                     RRVADVVQDVAEVADALELDRFAVAGRSGGAPHALACAALLPDRVTRAAALVTLAPRDA
                     KGLDWFAGMAPSNVHEFRTAFNDPERFVARLIPRSAKIRSNPARLLEELRGDLTADDRQ
                     IVADGAIRSMLLRNYHEALRSSPYGWVDDALALTGPWGFDPADIRVPVLLWHGAQDVFS
                     PAAHSTWLAGRIPRATAVLEPAAAHFAA"
     gene            complement(3859..7803)
                     /db_xref="GeneID:41542800"
                     /gene="fxsT"
                     /locus_tag="SAVERM_RS29470"
                     /old_locus_tag="SAV_5712"
                     /old_locus_tag="SAVERM_5712"
     CDS             complement(3859..7803)
                     /codon_start=1
                     /db_xref="GeneID:41542800"
                     /gene="fxsT"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478920.1"
                     /locus_tag="SAVERM_RS29470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5712"
                     /old_locus_tag="SAVERM_5712"
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /protein_id="WP_010987114.1"
                     /transl_table=11
                     /translation="MTAAQDGRIITFYSYKGGTGRTMALANTAWILAANGKRVLAVDWD
                     LEAPGLDRFFRPFLDPHALAATSGIIDIINEYAWAATSGSQRSGAWHQEYAHVEQHAVS
                     LTPERHGLRFAKGGSLDFLSAGRQDRSYSATVSSFEWDNFYERLGGGLFLDALRDDMKA
                     SYEYVLIDSRTGLSDNADICTIQMPDMLVDCFTLSDQSLDGAAAVARSVEDGYRKRKIR
                     VLPVPMRIDEGEKEKVDAGRALARLKFDGLPKGLGGEDLSPEELSQYWGAVEIPYRPYY
                     AYEETLATVGDESGIANSLLSAFERLTNVISDGEVASLPPVPEPVRLRCLDAFTRRRPL
                     TTAADVVVAYAAENRMWADWIEAVLKHSGCNVTLYDVSAGPVERPDAATRALVLLSNAF
                     QKSRYGEDVWRAFTGGDPDGAHPALVPLRVDEVRLPDSYLAHEPVDLHRLEEAQCVAGL
                     LSALELPAQPTDGAPAAPRFPGSTPATWNAPQRNQTFTGRNVILTQVREQLRSGMSVVL
                     PQPQALTGLGGVGKTQVALEYVHRFMADYDLVWWTSAESVDNVVASLAELGARIGAPGG
                     EDMALVSRETVQMLARGVPTKRWILIFDNADNPEQLTRYFPAGGGGHILVTSRNQAWAT
                     QGQSLPVDVFLRQESIEHLSRRAPGLTAHEADRVATAVGDLPLAVEQAAAWLAETATPI
                     EDYLRQLAEQTTDVLDLNQPADYPETVAATWNISIARLKDRSPASVRLLQLCAFLAPEP
                     ISSHLLYSKEMIDELRKVDPTLQESLLLGRVIREIARFALAKVDQVSNSIQVHRLVQAV
                     IRSQLTQEEQRHARHVVHTVLAGARPDGDEPIDDPETWPRFGVIWPHLSASDVRNCTEN
                     EPRRLLIDRVRYLWKRGDFPAAQQLAEDLLGHWKPLLGEEDVQYLYLRCQLANVMRSQG
                     RYVESRAINTELLEQQRRVLGAAHPHTYVTMSSLASDLAALGEYTLAVELAREAHDGFS
                     QIFHESHRRTLSAANNLALALRMVGRYGDARSLDQDTYDRRMEVLGPDHPYTLASAGRL
                     GRDLREVGRYEDSVSLLSRAYDAHKRILGKGFPGTLSCAKSLAVSLRRTGRLEDARRLT
                     TATRAQYRTQYDAHTPDSLACDLNMAADLYAADEREAAREVAKEALTEYMKVPGEEHPY
                     TQAALNNLGIFHWGCGDAVEAEAVFRQVLPRMSDVLGDRHPHTLFTEANFANVLADQGR
                     LEEAWALEKRAMDTLRTVLGPQHPETLAVVSNCALTLGALGRTDEARRLREETLAELNR
                     QGRQLGENNGIIQLTGHERRIYRDLEPLAV"
     gene            complement(7800..9134)
                     /db_xref="GeneID:41542801"
                     /locus_tag="SAVERM_RS29475"
                     /old_locus_tag="SAV_5713"
                     /old_locus_tag="SAVERM_5713"
     CDS             complement(7800..9134)
                     /codon_start=1
                     /db_xref="GeneID:41542801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009306786.1"
                     /locus_tag="SAVERM_RS29475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5713"
                     /old_locus_tag="SAVERM_5713"
                     /product="TIR-like protein FxsC"
                     /protein_id="WP_010987115.1"
                     /transl_table=11
                     /translation="MDAVERTSDNRPYFFLSYAHTPSWGSGGPNPDHWVHVLFADLCND
                     IMALTDLPGGAPAGFMDREMRSGDGWPEKLSENLATCRVFVPLFSPRYFTSEMCGREWF
                     AFHERILRARATGSGAVPAIVPALWTHVEYSQLPDSVRHIHVDHAAFGDRYAAQGFYGL
                     IKLNRFHDEYKETVLGLAQRIVQVAHDSPLPSSRPRPYESTPSAFKPRGEGPRRIHLTV
                     AAPTRDTIPEHRDARPYGEDAQDWNPYHSESTRALPSLAEELIRSLDYRTTVSSFDDED
                     PTGDIPAASVTEDGEDAADKVPPTRPGILLVDRWALLDEERRHRLKEFDAGARPWVSAI
                     VPWNRADLQCHGEEGRQLTEELDRTLPLILERGRRTDCRMAVTGVPTLKTFIDLLPAVV
                     AHTTRQYLKHAEAHPPSGPHLPRPRLMGPIHPQPPDAGPDNGGEA"
     misc_feature    complement(9085..9101)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.99"
                     /tool="antismash"
     gene            complement(9235..10008)
                     /db_xref="GeneID:41542802"
                     /locus_tag="SAVERM_RS29480"
                     /old_locus_tag="SAV_5714"
                     /old_locus_tag="SAVERM_5714"
     CDS             complement(9235..10008)
                     /codon_start=1
                     /db_xref="GeneID:41542802"
                     /gene_functions="resistance (resist) AAC3"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003913.1"
                     /locus_tag="SAVERM_RS29480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5714"
                     /old_locus_tag="SAVERM_5714"
                     /product="AAC(3) family N-acetyltransferase"
                     /protein_id="WP_010987116.1"
                     /transl_table=11
                     /translation="MTDVRQLSSLCDELGVRSGGTLLVHASLGGTGLRDTDVRDALLGA
                     LGPHGTLVVPTFTPENSDTSRAYRALTEGMDEREKAAFRAGMPPYEPDVTPCPTMGVLA
                     ECVRTTPGAVRSAHPQTSLAGLGPRAAELLSHHDPTCHLGERSPLARLYAAGAQVLLLR
                     VGFEVCSALHLAEYRMTPVPPTRTYRCVVEERGNWTSYEDLALNDGDFASIGALLPRDL
                     LSERAFSGKTAVLFAMRDVVDAATVRMSGYRYEMT"
     gene            complement(10001..12172)
                     /db_xref="GeneID:41542803"
                     /gene="fxsB"
                     /locus_tag="SAVERM_RS29485"
                     /old_locus_tag="SAV_5715"
                     /old_locus_tag="SAVERM_5715"
     CDS             complement(10001..12172)
                     /codon_start=1
                     /db_xref="GeneID:41542803"
                     /gene="fxsB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009306830.1"
                     /locus_tag="SAVERM_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5715"
                     /old_locus_tag="SAVERM_5715"
                     /product="radical SAM/SPASM protein FxsB, inactivated
                     metallohydrolase extension form"
                     /protein_id="WP_010987117.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.9e-72, bitscore:
                     243.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 8.7e-184,
                     bitscore: 609.4, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9e-12, bitscore: 44.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTDRDSSIQQLVLKIHSRCNLACDHCYVYEHEDQSWQARPVLI
                     AEETLDKVAHRLAAYTVDRKLESVSVILHGGEPLLVGPTRLRNICAQLRSVLDPLTTLD
                     LRIHTNGVRLNRAHLEILKEFDVKVGISLDGDRAANDRHRLDHRGRSSYDRVVQAVELL
                     RTEEYRHLYLGLLCTVDVANDPVVVHDALSALDPPRIDYLLPHSTWDNPPPSGPSGSPT
                     PYADWLLKIFDRWLEQGRTVPVRTFDSVLSTLRGGPSLTEAMGLAPSDLAVVETDGTFE
                     QADSLKTAYDGAPATGYDVFRHTFEEFARHPGVRARQLGIEGVSETCRGCPVVQSCGGG
                     LYAHRYSTERGFDNPSVFCADLRAFVDGVAERITERELSPAVRGGDELRLAQLRLGREV
                     LARAHDRLAGDPDADEAWRALVRLDTDDATAPHLNSVLAHPYLRPSLHGSWDGRAGLAR
                     FMTVAAAAAVHAEAGVTLAWHQPDRELHLPTLGTVRLARPGRVELTVTRDGFRIRGADA
                     TPDEPPAEWRPLETLPLTDGTSFLIDDADPHRDCYPVPVAPPLGSSDLRVFRKRLRAAY
                     ELLDEREPGRRDRVDALVVTTVTPLMAGTGVRLGDHGIGALGVAVDFEPEEFVRELSRA
                     GRRARLTALRQVADLSVPGNRAGRLLEEASEQLGTASYWRQEPELRAEALAGADRALRT
                     LAALPERDLTESGAVFAAQLRTEWQRLHD"
     gene            complement(12271..12453)
                     /db_xref="GeneID:41542804"
                     /gene="fxsA"
                     /locus_tag="SAVERM_RS29490"
                     /old_locus_tag="SAV_5716"
                     /old_locus_tag="SAVERM_5716"
     CDS             complement(12271..12453)
                     /codon_start=1
                     /db_xref="GeneID:41542804"
                     /gene="fxsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478914.1"
                     /locus_tag="SAVERM_RS29490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5716"
                     /old_locus_tag="SAVERM_5716"
                     /product="FxSxx-COOH cyclophane-containing RiPP peptide"
                     /protein_id="WP_010987118.1"
                     /transl_table=11
                     /translation="MNLTVTKTKRGSAAAQPTHKKLAPLSAINTHEAAALRSTGRVTDI
                     PGRRPTKPITFDSAL"
     misc_feature    complement(12438..12452)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     gene            12700..13614
                     /db_xref="GeneID:41542805"
                     /locus_tag="SAVERM_RS29495"
                     /old_locus_tag="SAV_5717"
                     /old_locus_tag="SAVERM_5717"
     CDS             12700..13614
                     /codon_start=1
                     /db_xref="GeneID:41542805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478910.1"
                     /locus_tag="SAVERM_RS29495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5717"
                     /old_locus_tag="SAVERM_5717"
                     /product="DUF4231 domain-containing protein"
                     /protein_id="WP_042493718.1"
                     /transl_table=11
                     /translation="MRAVTPGPSTTLTEDDLPPLYAVNDRRALSRQSESFRAVRTQLVV
                     LLLATGTAMLAERLNSHIPAACAAVLYALTIAVGLHSSRRRARAHWQAHRAAAETLKSL
                     AWMYMVHGGPFHSGVTHPDALFAERLEERLRELRKVGWEDSRDGPATVGAGQITPVMRA
                     VRAKPFGARRDLYLRERVLEQLTWYGNRASQAHRSSVRWSSVTALLTLLALIAAVLRAA
                     GVIGRWDLTGLLSASAAAGVAWQEVRRHRPLTYAHKLIEQDLDTLRIAMGTTVTEEGWA
                     ESVAEAERLVSPQHTDWLVRFGS"
     gene            complement(13635..14111)
                     /db_xref="GeneID:41542806"
                     /locus_tag="SAVERM_RS29500"
                     /old_locus_tag="SAV_5718"
                     /old_locus_tag="SAVERM_5718"
     CDS             complement(13635..14111)
                     /codon_start=1
                     /db_xref="GeneID:41542806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003917.1"
                     /locus_tag="SAVERM_RS29500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5718"
                     /old_locus_tag="SAVERM_5718"
                     /product="hypothetical protein"
                     /protein_id="WP_010987120.1"
                     /transl_table=11
                     /translation="MTRIGVTGHRRIPAVVLPAVLAGITGELRRHAAVEALSCLAAGAD
                     QLFADLALDSGVPLTAVIPGMDYEAHLGGDEVQASYRRLLKSCTARVDLPVEPTHEEAY
                     YAAGRWIVDHADRLVAVWDGQPARGLGGTADVVAYARRTGVPVRVLWSSGVLRS"
     gene            complement(14265..15806)
                     /db_xref="GeneID:41542807"
                     /locus_tag="SAVERM_RS29505"
                     /old_locus_tag="SAV_5719"
                     /old_locus_tag="SAVERM_5719"
     CDS             complement(14265..15806)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542807"
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006376191.1"
                     /locus_tag="SAVERM_RS29505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5719"
                     /old_locus_tag="SAVERM_5719"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_010987121.1"
                     /transl_table=11
                     /translation="METVPRLPVPLLRAVLGVGTDLELEPTLQHIVDSAAELTGARYAA
                     LATADPGHEELARVHRAGPARGGPAPHGPARPGRGDDWLGVPIHVHDQEFGTLYLTGKS
                     GGPFTDKDERMLCVLAAQAGIAIDNVRLYATARQRERWIEGAAAVTTALLTGQNATDAL
                     MTVAERARILAGAAAGVILKPTPEGGMEIVTASTPDDPGDIVGTTIEPGSPVLAQLLGG
                     EAVFIDDTATDPRMTTRVRHRFGPSMMLPLEAEGRLIGTLALPRRRGGRPYTPVEQQLA
                     AQFASQAALALVLADMWHSRKRLAVYEDRDRIARDLHDLVVQRLFATGMMLESTQRRAA
                     EEDVHETLGRAVDALRSTVQEVRTAIFALQQPPADAPTTFRGKVLRETAGAAGVPGFRP
                     STRFIGPVDSLVPEAVAGHLLAALRRALAAASHRPGVARVEVTVDATATLPDGRAGVRL
                     TVHDDGVPDDHEGVPKEREGVPENDGRAAEHGDGASRGTGTGTGTGTTVTWQYPL"
     gene            complement(15834..16871)
                     /db_xref="GeneID:41542808"
                     /locus_tag="SAVERM_RS29510"
                     /old_locus_tag="SAV_5720"
                     /old_locus_tag="SAVERM_5720"
     CDS             complement(15834..16871)
                     /codon_start=1
                     /db_xref="GeneID:41542808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006376286.1"
                     /locus_tag="SAVERM_RS29510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5720"
                     /old_locus_tag="SAVERM_5720"
                     /product="rod shape-determining protein"
                     /protein_id="WP_010987122.1"
                     /transl_table=11
                     /translation="MTVSLDRLRRCHFAVDLGAARTRVYVKGAGLVVDQPSAAAINTRT
                     GALIAVGEFAEKMTGRTPAYIRVVRPVSGGTVVDIEMAQRMLRHLLGEKLRRALRRKPR
                     LRAAACTPHDADPLAQRATIETLVGLGARRVELVDTLVAAAVGCGLPVERPEASMIMVC
                     GAAATQIAVLSLGSIVTADRIPVGGEAVDHAIVQHLRHQHELMLPSQSVRPLQIALSGN
                     GLTPHGPTSTEIHGRDVATGLARSVLVDTAAVRNAIQTPLTAVLDGIGKVLRDCPPDLV
                     ADLADRGIMMVGGSALLPGLDQMLRQATGMPVSIAERPDVCAIQGLGAMLEGRIEPLLL
                     ERVAG"
     misc_feature    complement(16836..16848)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            17438..21064
                     /db_xref="GeneID:41542809"
                     /locus_tag="SAVERM_RS29515"
                     /old_locus_tag="SAV_5721"
                     /old_locus_tag="SAVERM_5721"
     CDS             17438..21064
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542809"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028358.1"
                     /locus_tag="SAVERM_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5721"
                     /old_locus_tag="SAVERM_5721"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_010987123.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.5e-55, bitscore:
                     186.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRGPARRGAALLSAGLVFALLPMGRAAARDAGTPPSPQPASTAR
                     TVTLVTGDTVTVTDLPGGKKTVTVERPRGATGAVRTQVVGGAVSVVPDEALPYLRAGTL
                     DRRLFDVSALIRQGLSDRKTGETPLIVGYGKGARAVTPSGATRTRSLTSIGAAAVDADK
                     GRTFWRSWTRQGGIEHVWLDARVEADMAESNAQIGTRAAWDAGLTGDGVTVAVLDTGVD
                     TTHPDLAGRVSRSKSFIDGEEVADRNGHGTHVTSTVGGSGAASDGTERGVAPGATLAVG
                     KVLSDQGAGSESQIIAGMEWAARDVRARIVSMSLGSTEASDGTDPMAEAVDTLSEETGA
                     LFVVAAGNTGAPSSIGSPGAADSALTVGAVDSSDRAAYFTSAGPRHGDNALKPDLAAPG
                     VDIRAARSQLAPGTGYYTSMSGTSMATPHVAGVAALLAEQHPDWTGARLKDALMSTSEQ
                     LDASVYQLGAGRVSVPDAVGARVTATGSADLGFHRWPHDADRPVTKTVTYSNSSDTTVE
                     LSLAVRGAPAGVATLADTALTVPAHGTAATTVTGDGSKAPVGETSGQIVASAGGAPVAH
                     TAFGLVKEAERYSLTVHVKDRAGAATAAGLVVQRLAAGTDPYPASVGDSGTLALRLAPG
                     TYSLTSFLDVRGGHGADSLGLGFLAAPEITLDRDRAITLDGSRLREVEADVDRRTETRQ
                     LLMEYDRSGGGSDLFGAVQVPLTYDSVFAAPTPKVTEGSFEYRTVWRLGKPLLEVRGIR
                     EAVVQSGGTLTEGRSRPPLVDVGSFTGGVLTGVRGRAVLARLGDGVEPTALAQAAQDAG
                     AKALFVTDDSAGRLTAWWGTDDNADRPLQIATVNAADAARLRAAGGRIDMTGTPNTPYV
                     YDLSEGHRGRIPDRDLTYRPGRRELATVRARFHAVRPVGGGEFRYSLTDAFPVGIGFRE
                     RIDYPAERTDHVSTGPGQLWHESVTVGDGTLEERGGLNRYQGGAHTALDWFKPVWHPWL
                     GTGLGWGQERSGAMMRFNTPGWGDSGPDHTGFGDVWSDDSGMTQVTAVHQDGTLVDRRT
                     GSGAYVWDAPADEHTYKVVTDTTLDPDRWKLSTKGHAEWTFRSSATPDDRWTFLPLLNL
                     AFDIGTGLTGDVRGGGRVPVGLFASYVAGAPDTGTIGAGHLEVSYDDGTSWQPVRLSGG
                     TASWHGTLTVPGTAHHISLRASARDDRGGSVEQEIIRAVGVR"
ORIGIN
        1 ccgtcgggtg ggctgtgccc gcggcatgac agcaggacgt cgcgatcgat gccgtgagcg
       61 gtcgacccgt ccggtggtaa ccgggcccgg acctgtgagg tccactcgcg cagcgtctgc
      121 gagagcggtg cgacggaacg agatcgacgc cccgggctcg ggcccggggc gtctccttgg
      181 gtcactggat cggggcgtcg ggcgggggga ggtggacggt gcggtccctg tcgacggatt
      241 cgatgccggc gaccgccttc agggccggga tccggtcctc cgcgatggtg ccggagagcg
      301 tgccgaggat cgcctgctcg cccgtgaccg tcagcccggc ccctcgcgcg gcctcgacca
      361 cctccgcgaa ccggtcgggg tcgaccgaaa ggatgacccc gaccggcccg gaagagggcg
      421 actcgctcac ggggcctgga gcaggcccga gccgacgtcc ctgacgggct gcgtcagcgg
      481 gaacgcactg gacagcagac tggccttgag atcctccgca gaggcgttgg gggcggcctg
      541 ggcgagcagc gcgaggacac ccgcgacgtg cggtgtggcc atgctggtgc ccgacatcga
      601 ctggtacccg ccgccagggg ccgccgagtg cacggccctg ccgggcgcgg cgatgttgac
      661 ctcgccgccc tggccgttga tgcccgcgga ggagaaggac gacaccgtga gtgccctgtc
      721 cagcgaggcc accgcgagga tggagggaca gttggcgggt cggccgaccg gcctgatggc
      781 ctgggggcgg ctgctttcgt tgcccgcggc ggcgacgatc actgtcccgc gctggagcgc
      841 acgctgggcc agctgctcgt aggtctgggg gaagagctca cccggctgga ccgcggcgcc
      901 gagcgacatg gagatcaccc gcgcgccgtg ggcgacggcc caggccatgg ccgccaggat
      961 ctggccgtcg gtaccgctgc ccgcgttgct gagcaccttc gcggcgagta cccgggcctc
     1021 gcttgccacg ccgtagcggg gcccctgctg gggactggcc ggaccggcgg cggtgccgat
     1081 gcagtgcgtg ccgtggccat ggccgtcctc gacggtctcg ccgggcacga aggagaccgt
     1141 ctcgtctatg cgcccggcga ggtccgggtg gtcggtgtcc acgccggtgt cgagcacggc
     1201 gatcttcaca ccgcgcccgg tcaggctgga catgttggcc cggatcgcct ggaggcccca
     1261 ggtccagttc cgctcgtccc aagccgggcc ctgggccgcg gcgatttcgg ccttggtgtg
     1321 gcgttccacc actccctcgt cgctgcggta ggccgggaag aacgcggtcg gcgcctgctg
     1381 gggagcggtg atcaccgagg cgtagaccat gcgctccggc tcggccgcga tgatcgaggg
     1441 ctccgcctcg gccgtggtca ccagcgcgtg gcgctggtcg ggccgcactt cgacgacggc
     1501 ggcgcccagt tcttcgaaga gcaccgagac gtcggggcgc tccaggagtt cggcgacgtt
     1561 cgcggcgtcg gtcccgcgta tacgctccac cggcgcgatg tcggcggagg cacgcagggc
     1621 ctccaatccg ctctcctggt tgctctggtc gagcaggatc acgtaccgcc cggtgtactc
     1681 cgcgccccgt cccgtgaagg gggcatcggg ccgatccggc tgctcgccga aggcgcgcct
     1741 gtccatgggt ccgttcgcca ttgaatttcc cgctttctgt gcgcatcccc cggttcgtgg
     1801 acgcgcgccg actcacgggg tgccgggcgc caaggatggt ggggcgcgct tcagccgtgt
     1861 atcgacgcgt ggtgccgtcg ccggcaaggc tgtcccctgc caggccgcta cttcggcaac
     1921 gccccctggt acaccgtcgc accgggtacg ggggcccgca acacagcgtc gccgcgcacc
     1981 ggcagagccc ggcgtcagcg cagggtgtcg atcacctcgt cgtcggagag ctgctcgaag
     2041 tcctcgtacc actctccgac ggcgtagaag agttccggct cgtagaggca gatgacgtcg
     2101 tcggcctcct cgtgcagcgt ctcgacggcg cgggagccga ccggtacggc gaggatcagg
     2161 ccggcggccc cctgtccgcg caggtgacga agggcggccc gggcggtgac accggtggcg
     2221 agtccgtcgt ccacgaggat cacggtgcgg ccgcggatcc gcggcgcggg gcgtccggcg
     2281 cggtagcgct cctcgcggcg gtggacctcc gcccgctgat cggccacggc ctgagtgagc
     2341 tgcgcctcgg tgagccccag aacggcgagc gagctcttgt cgaagaacgg cggatcgtcg
     2401 cccgcgacgg caccgatccc ggactccgga cggcccggcg ctccgatctt gcgcaccacc
     2461 agcacgtcca gcggggcctt gagggcgtgg gcgatctcgg cggcgacggg gacaccgcca
     2521 cggggcaggg ccaggacgag cgggtcggtc agctcgccct tctccgcccg cctcaggagt
     2581 tcggcggcca gctcccggcc ggcctgccgg cgatcccgga aacgcatgac acccgcctcc
     2641 tcccggcccg ggttccccac cggtgggggg ccaaacgacg gggccgaacg acggggccga
     2701 acgacggggc cgaacgaggg ggccaagtga cgggaccgaa cgacggtacc ggcgggcggc
     2761 gcctgaggcg atgccacgta ccggacgctc ccgtgatctc cgccgatctc cgccgtgagc
     2821 atccgtgcgg gggccgtcgt caagtggcct gatatggagc cgtatcgacc tgccggttcg
     2881 tttcatgggt ctgccccttg ggcaggcatc gggcagcgtg ttctcggccc atgggccgag
     2941 ggagggggag cgctgtgcag actcagacgc gcatgctcga ccaggtccgg acgacggacg
     3001 gacgactgct caaggtcgag atctcggggg atccacgcgg ccggccggtg ttcctgctgc
     3061 acggcatgcc cggcagccgc gtcggccccc ggcctcgccc gatgttcctc taccagcgcg
     3121 gcgcccgcct gatcagctac gaccgccccg gctacggggg ctcggaccgc aaggcgggcc
     3181 gccgcgtcgc cgatgtcgtc caggacgtgg ccgaagtcgc ggacgcgctg gagctggacc
     3241 ggttcgccgt ggccgggcgc tccggcgggg cgccgcacgc gctggcctgt gccgcgctgc
     3301 tgcccgaccg ggtcacccgg gccgccgccc tggtcacgct cgccccgcgg gacgcgaagg
     3361 ggctcgactg gttcgcgggc atggccccgt ccaacgtcca tgagttccgc accgcgttca
     3421 acgatcccga gcggttcgtg gcccggctca tcccgcgctc ggccaagatc cgcagcaatc
     3481 cggcacggct gctcgaagag ctgcgcggcg acctgacggc cgacgaccgg cagatcgtcg
     3541 cggacggcgc catccgctcc atgctgctgc gcaactacca cgaggcgctg cgcagttcgc
     3601 cctacggctg ggtcgacgac gcgctcgcgc tgaccggccc ctgggggttc gacccggccg
     3661 acatccgggt gccggtgctg ctgtggcacg gcgcgcagga cgtcttctcg ccggccgcgc
     3721 actccacctg gctggccggc cgtatcccgc gcgccaccgc ggtcctcgaa cccgcggcgg
     3781 cgcacttcgc ggccctgcgt gccctgccgg cggtcctgac ctggctcctg gcggacgccg
     3841 cgcggcaggg ctgagggctc acaccgccag cggctccagg tcccggtaga tccgccgctc
     3901 atgccccgtc agctggatga tcccgttgtt ctcgcccaac tgccgcccct ggcggttcag
     3961 ttcggccagc gtctcctcgc gcagccggcg cgcctcgtcc gtacggccca gggcgcccag
     4021 cgtcagcgcg cagttgctga ccacggccag ggtctccggg tgctgcggtc ccagcaccgt
     4081 gcgcagggtg tccatggccc gcttctccag cgcccaggcc tcctccagac ggccctgatc
     4141 ggccagtacg ttggcgaagt tggcctccgt gaacagggtg tgcggatgcc ggtcgccgag
     4201 cacgtccgac atcctgggca gtacctgccg gaacacggcc tccgcctcga ccgcgtcccc
     4261 gcagccccag tggaagatgc ccaggttgtt cagcgcggcc tgggtgtagg ggtgttcctc
     4321 gcccggcacc ttcatgtact cggtcagcgc ctccttggcg acctcgcgcg ccgcctcccg
     4381 ctcgtcggcc gcgtacaggt cggccgccat gttcaggtca caggcgagcg agtccggggt
     4441 gtgggcgtcg tactgggtcc ggtactgggc gcgggtcgcc gtcgtcagcc ggcgggcgtc
     4501 ctcgaggcgg cccgtcctgc gcagtgacac ggcgagggac ttggcgcagc tcagcgtgcc
     4561 ggggaagccc ttgccgagga tgcgcttgtg ggcgtcgtac gcacgcgaca gcagggacac
     4621 cgagtcctcg taccggccga cctcgcgcag gtcgcgcccc aggcggcccg ccgaggccag
     4681 cgtgtacggg tggtcggggc cgagcacctc catacggcgg tcgtaggtgt cctggtcgag
     4741 ggagcgcgcg tcgccgtagc ggccgaccat ccgcagcgcg agggcgaggt tgttggccgc
     4801 gctgagggtg cgccggtggg attcgtggaa gatctggctg aacccgtcgt gcgcctcgcg
     4861 cgccagttcc accgccaggg tgtactcgcc gagcgcggcg aggtcgctgg cgaggctgga
     4921 catggtgacg tacgtgtgcg gatgtgcggc cccgagcacc cggcgctgct gctcgagcag
     4981 ctcggtgttg atcgcccggg actccacgta acgcccctgg gagcgcatca cgttggcgag
     5041 ctggcagcgc agatacaggt actgcacgtc ctcctcgccc agcagtggct tccagtgtcc
     5101 gagcaggtcc tcggcgagct gctgcgccgc cgggaagtca ccgcgcttcc acaggtagcg
     5161 gacgcggtcg atgagcagac ggcgtggttc gttctcggtg cagttgcgga cgtcggaggc
     5221 gctcaggtgc ggccagatga cgccgaaccg cggccaggtc tccgggtcgt cgatcggctc
     5281 gtcaccgtcc ggccgggcac cggccaggac cgtgtggacg acgtgccggg cgtgccgctg
     5341 ctcctcctgc gtcagctgcg agcggatcac cgcctggacc agccggtgca cctggatgct
     5401 gttgctgacc tggtcgacct tggcgagcgc gaaacgggcg atctcccgga tgacccggcc
     5461 gaggagcagg ctctcctgga gggtggggtc gaccttgcgc agctcgtcga tcatctcctt
     5521 gctgtagagc agatgggagg agatcggctc gggcgccagg aacgcgcaca gttgcagcag
     5581 ccgtaccgag gcgggcgagc ggtccttgag gcgggcgatg gagatgttcc aggtcgcggc
     5641 caccgtctcg gggtagtcgg cgggctggtt gaggtcgagg acgtcagtgg tctgctcggc
     5701 cagctgtcgc agatagtcct cgatcggggt ggcggtctcg gccagccacg ccgccgcctg
     5761 ttccacggcc agcggcaggt cgcccaccgc ggtcgccacc cggtcggcct cgtgggcggt
     5821 gagccccggc gcacggcggg agaggtgctc gatgctctcc tggcgcagga acacgtcgac
     5881 gggcagggac tggccctggg tcgcccacgc ctggttgcgg gaggtgacga ggatgtgccc
     5941 gccgcccccg gccgggaagt agcgggtgag ctgctcgggg ttgtcggcgt tgtcgaagat
     6001 caggatccag cgcttggtgg gcaccccgcg ggcgagcatc tgcacggtct cgcggctgac
     6061 cagggccatg tcctcgccgc cgggcgcgcc gatgcgggcg cccagctcgg cgagcgaggc
     6121 gacgacgttg tccacggact cggcggacgt ccaccacacc aggtcgtagt cggccatgaa
     6181 ccggtgcacg tactccagcg ccacctgcgt cttgccgacg ccgccgaggc cggtcagggc
     6241 ctgcggctgc ggaagcacga cggacatgcc ggagcgcagc tgctcgcgga cctgcgtgag
     6301 gatgacgttg cggccggtga aggtctggtt gcgctggggg gcgttccagg tggccggggt
     6361 gctgcccggg aagcgggggg ccgccggggc gccgtcggtg ggctgggcgg gcagctccag
     6421 ggcgctgagc aggccggcga cgcactgggc ctcttcgagg cggtgcagat cgacgggctc
     6481 gtgggcgagg taggagtcgg gcagccgcac ctcgtcgacg cgcagcggga ccagcgcggg
     6541 gtgggcgccg tccgggtcgc cgccggtgaa ggcgcgccag acgtcctccc cgtaccggga
     6601 cttctggaag gcgttcgaca gcaggacgag cgcgcgggtc gccgcgtcgg ggcgttcgac
     6661 cgggccggcg gacacgtcgt acagcgtgac gttgcagccg gagtgcttga ggacggcctc
     6721 gatccagtcg gcccacatgc ggttctcggc cgcgtacgcg acgacgacgt cggccgccgt
     6781 ggtcagcggc cggcgccggg tgaacgcgtc caggcagcgc agccgcaccg gctcgggcac
     6841 cggcggcagc gaggcgacct cgccgtcgga gatgacgttg gtcagccgct cgaacgccga
     6901 cagcagcgag ttggcgatcc cgctctcgtc gccgaccgtc gcgagtgtct cctcgtacgc
     6961 gtagtagggg cggtacggga tctcgacggc gccccagtac tgggacagct cctcggggct
     7021 gaggtcctcg ccgccgaggc ccttgggcag tccgtcgaac ttcagccggg ccagcgcccg
     7081 tccggcgtcg accttctcct tctcgccctc gtcgatgcgc atcggcaccg gcagcacccg
     7141 gatcttgcgc ttgcggtagc cgtcctcgac gctgcgcgcc acggccgccg cgccgtccag
     7201 ggactggtcg ctgagcgtga agcagtccac cagcatgtcg ggcatctgga tggtgcagat
     7261 gtcggcgttg tcggacaggc cggtgcggga gtcgatcagg acgtactcgt acgacgcctt
     7321 catgtcgtcg cgcagcgcgt ccaggaagag accgccgccg agccgctcgt agaagttgtc
     7381 ccactcgaag gaggacacgg tcgccgagta cgagcggtcc tggcgcccgg cggagaggaa
     7441 gtcgagcgag ccgcccttcg cgaagcgcag accgtgccgc tcgggggtga gtgagacggc
     7501 gtgctgctcg acgtgggcgt actcctggtg ccaggccccg gaacgctggc tgccgctggt
     7561 cgcggcccag gcgtactcgt tgatgatgtc gatgatcccg gaggtggccg cgagcgcgtg
     7621 ggggtcgagg aacgggcgga agaagcggtc caggcccggc gcctccaggt cccagtcgac
     7681 cgccaggacc cgtttgccgt tggcggccag gatccacgcc gtgttggcga gggccatcgt
     7741 gcgcccggtg ccgcccttgt acgagtagaa cgtgatgatc cgtccgtcct gcgcggccgt
     7801 catgcctctc ctccgttgtc gggtcccgcg tccgggggct gcgggtggat ggggcccatc
     7861 agtcggggcc tgggcaggtg ggggcccgaa ggcggatggg cttccgcgtg tttcaggtac
     7921 tgccgggtgg tgtgggcgac cacggccggg agcaggtcga tgaaggtctt cagggtgggt
     7981 acgccggtga cggccatccg gcagtcggtg cgccggcccc gctcaaggat cagcggcagg
     8041 gtgcggtcca gctcctcggt gagctggcgg ccctcctcgc cgtggcactg gaggtcggcg
     8101 cggttccagg gcacgatcgc gctgacccag ggccgggcgc ccgcgtcgaa ctccttgagt
     8161 ctgtgccgcc gttcctcgtc gaggagcgcc cagcggtcga cgagcaggat gccggggcgg
     8221 gtcggcggca ccttgtcggc ggcgtcctcg ccgtcctcgg tgaccgaggc ggccgggatg
     8281 tcgccggtcg ggtcctcgtc gtcgaaggag gagacggtgg tgcggtagtc cagcgagcgg
     8341 atcagctcct cggccagtga ggggagcgcc cgggtggact ccgagtggta cgggttccag
     8401 tcctgggcgt cctccccgta agggcgggcg tcgcggtgct cggggatggt gtcccgggtg
     8461 ggtgcggcca ccgtcagatg tatgcgccgg ggtccctcgc cgcgcggttt gaaggcgctg
     8521 ggcgtggact cgtaggggcg gggccggctg gagggcagcg gggagtcgtg ggcgacctgc
     8581 acgatgcgct gggcgagacc gaggacggtt tccttgtact cgtcgtgaaa ccggttgagt
     8641 ttgatcagac cgtagaatcc ctgggccgcg taacggtccc cgaaggcggc gtggtccacg
     8701 tgtatgtgcc ttacggagtc ggggagttgg ctgtattcga cgtgtgtcca caaggccggc
     8761 acgatcgcgg gcaccgcccc tgaaccggtg gcgcgggccc gcaggatcct ctcgtggaag
     8821 gcgaaccact cgcgcccgca catctcgctg gtgaagtacc tcggcgagaa caggggtacg
     8881 aatacccggc aggtggccag gttctcgctg agcttctccg gccagccgtc cccggagcgc
     8941 atctcccggt ccatgaaacc cgcgggtgcc ccgcccggca gatcggtgag cgccatgatg
     9001 tcgttgcaca ggtcggcgaa caggacgtgc acccagtggt cggggttcgg gccgcccgaa
     9061 ccccaggacg gcgtgtgggc ataactgaga aaaaagtacg gcctgttgtc cgaagtccgt
     9121 tcaactgcgt ccacgcgccc ccctgcccat gaagccccgc ctcaccccgt cgaaggcgtc
     9181 atctggccgg acaccataat gtgcccgacc gacggcccgc aggggccgtt tgtttcacgt
     9241 catttcatag cgatatccgg acatccgaac agtcgccgcg tcgacgacgt cccgcatggc
     9301 gaacagaacg gccgtctttc ccgaaaatgc ccgttccgac agaagatcac gcggcagcag
     9361 cgccccgatc gacgcgaagt cgccgtcatt cagggcgaga tcctcgtacg aggtccagtt
     9421 tccccgctct tcgaccacac agcggtacgt gcgcgtcggc ggcaccggtg tcatccggta
     9481 ctcggccaga tgcagcgcgc tgcacacctc gaaccccacg cgcagcaaca ggacttgggc
     9541 cccggcggcg tacagcctgg ccagcggtga gcgttcgccg aggtggcagg tcgggtcgtg
     9601 gtgcgacagc agctcggcgg cgcgcggccc gagtccggcc agcgaggtct gcgggtgcgc
     9661 gctgcggacg gcaccgggcg tcgtccgtac gcactcggcg agcacgccca tggtggggca
     9721 gggggtgacg tcgggctcgt acgggggcat gcccgcccgg aacgccgcct tctcccgctc
     9781 gtccatcccc tcggtgagcg cccggtacgc gcgggaggtg tccgagttct cgggcgtgaa
     9841 cgtggggacg acgagtgtgc cgtgcgggcc gagcgcgccg agaagggcgt cccggacatc
     9901 ggtgtcgcgc agcccggtcc cgccgaggga ggcgtggacc agcagggtgc cgccggagcg
     9961 cacccccaac tcatcgcaca acgaactcag ttgccgcacg tcagtcatgg aggcgctgcc
    10021 actccgtccg cagctgggcc gcgaagacgg cgccgctctc ggtcaggtcc cgttccggaa
    10081 gggcggccag ggtccgcagg gcgcggtcgg cccctgccag tgcctcggcc cgcagctcgg
    10141 gctcctgccg ccagtacgag gcggtaccga gctgttcgct cgcctcttcg agcagccgtc
    10201 cggcccggtt gcccggcacg ctcagatccg ccacctgccg cagcgccgtg agccgggccc
    10261 ggcgtccggc gcgggacagt tcgcggacga actcctccgg ttcgaagtcg acggccacgc
    10321 ccagggcgcc gatgccgtgg tcgccgagcc gcacgcccgt tccggccatc agcggggtga
    10381 ccgtggtgac gacgagcgcg tccacgcggt cacgccggcc gggctcgcgc tcgtcgagga
    10441 gctcgtacgc ggcgcgcagc cgcttgcgga agacgcgcag gtcgctggag ccgaggggcg
    10501 gagcgacggg gacggggtag cagtcgcggt gcgggtcggc gtcgtcgatg aggaaagacg
    10561 tgccgtccgt gagcggcagg gtctccagcg ggcgccattc ggcgggcggc tcgtcgggcg
    10621 tggcgtcggc gccgcggatg cggaagccgt cccgcgtcac cgtgagctcg acccgccccg
    10681 gccgcgccag ccgtaccgtc cccagcgtcg gaaggtgcag ttcccggtcg ggctggtgcc
    10741 aggcgagggt cacgccggcc tccgcgtgca ccgcggccgc cgcggccacc gtcatgaacc
    10801 gggcgagacc ggcgcgcccg tcccaggagc cgtgcagcga ggggcgcaga taggggtggg
    10861 cgaggacgga gttgagatgc ggggcggtgg cgtcgtccgt gtccagacgt acgagcgccc
    10921 gccaggcctc gtcggcgtcc ggatcgccgg cgaggcggtc gtgcgcccgc gccagcacct
    10981 ctcgccccag cctgagctgc gccagccgga gttcgtcccc gccacgcacc gcgggggaca
    11041 gctcccgctc cgtgatccgc tcggccaccc cgtccacgaa ggcccgcaga tccgcacaga
    11101 acacggacgg attgtcgaat ccccgttcgg tgctgtagcg gtgggcgtag aggccgccgc
    11161 cgcacgactg gacgacgggg cagccgcggc aggtctcgct gacgccctcg atgcccagct
    11221 gccgggcccg gacgccggga tgccgcgcga actcctcgaa cgtgtgccgg aagacgtcgt
    11281 atccggtggc cggggcgccg tcgtacgcgg tcttcaggga gtccgcctgt tcgaacgtgc
    11341 cgtccgtctc caccaccgcg aggtcggagg gggcgagccc catcgcctcg gtgaggctgg
    11401 gcccgccgcg cagggtgctg aggacggagt cgaaggtgcg caccgggacc gtacgcccct
    11461 gctccagcca ccggtcgaag atcttcagca gccagtcggc gtacggagtg ggcgaaccgg
    11521 acgggccgga gggcggcgga ttgtcccagg tggaatgcgg aagcagatag tcgatacgcg
    11581 gcgggtccag cgccgacagc gcgtcatgta ccacgaccgg atcattggcc acatccaccg
    11641 tgcacaaaag gcccaggtag agatggcggt attcctcggt gcgcagaagt tcgacggcct
    11701 ggacgacccg gtcgtaactg ctgcggcccc ggtggtcgag gcgatgacgg tcattggccg
    11761 cccggtcacc gtcgagcgag ataccgacct tgacgtcgaa ttccttcagg atctccagat
    11821 gcgccctgtt cagccgcacg ccattggtgt gaattcggag atccagggtg gtcagtgggt
    11881 ccagaacgct ccggagctgc gcacagatgt tccgcagtcg ggtcggtccc acgaggagcg
    11941 gttcgccgcc gtgaaggatc acggaaaccg attcgagttt ccggtccacc gtgtatgcgg
    12001 cgagccggtg ggcgactttg tcgagggttt cctcggcgat caggaccggg cgtgcctgcc
    12061 agctctggtc ctcatgctcg tacacatagc agtgatcaca tgcgagattg cacctgctat
    12121 ggattttcag aaccagctgc tggatcgagg aatccctgtc cgtgtccgtc acttaccaca
    12181 gtctagggcc ttaaaacacc ccgcgatgcc accaactcgc ttgttgatca agggagttgg
    12241 cggatcacgg gcgtgggtgc gtccggtgcg ttacagtgcc gagtcgaatg tgatcggttt
    12301 ggtggggcgc ctgcctggaa tatcggtcac tcggccggtc gaccgcaggg cggcggcctc
    12361 gtgggtgttg atggccgaga ggggcgcgag cttcttgtgg gtcggctgag cggcggccga
    12421 accgcgcttc gtcttggtga ccgtgaggtt catgggtcta gctcctgagt tcgggtctgt
    12481 cgccgtgccc cacgggggac cacgtcccga gagggatcga gcatgagacc cgagacagag
    12541 tgctattacg cgacccttct atcacggcct ctcaagcttc tgcgagtggc ttgctgctgc
    12601 gagcgggtgg tactggtcgg ctcctggggg tagtgctggg cgcctttcgg gaggaacatg
    12661 gcgacactgt cctcataagt ctgcctccgc gaggtgtcaa tgcgcgcggt gacgcccgga
    12721 ccgagtacga cgctcaccga ggacgacctg ccgccgctct atgccgtcaa cgatcgccgc
    12781 gcgttgagcc ggcagagtga gtcgttccgc gccgtccgta cccaactggt cgttctgctg
    12841 ctcgccaccg gtaccgcaat gctcgccgag cgactgaaca gtcatattcc ggcagcatgt
    12901 gcggcggtcc tttatgcgtt gacgatcgcc gtcggcctgc actcctcccg ccgccgggcg
    12961 cgcgcccact ggcaggcgca ccgtgcggcg gccgagaccc tcaagtcgct ggcgtggatg
    13021 tacatggtcc acggcggccc cttccactcc ggtgtcaccc acccggacgc cctgttcgcc
    13081 gagcggctgg aggagcggct ccgggaactg cgcaaggtgg ggtgggagga ctcccgggac
    13141 ggaccggcga cggtcggggc ggggcagatc accccggtga tgcgggccgt tcgggccaag
    13201 ccgttcgggg cgcgccggga cctctatctg cgcgagcggg tcctggagca gctgacctgg
    13261 tacggcaacc gggcctccca ggcccaccgc tcgtccgtgc gctggtcctc cgtcacggcc
    13321 ctgctgacgc tgctcgcgct gatcgcggcc gtgctcaggg ccgccggggt gatcggccgc
    13381 tgggacctga ccgggctgct cagcgcgtcc gcggcggcgg gcgtcgcctg gcaggaggtc
    13441 cgcagacacc gcccgctcac ctacgcgcac aagctgatag agcaggacct ggacaccctg
    13501 cggatcgcga tggggacgac ggtcacggag gaggggtggg ccgagtcggt cgcggaggcg
    13561 gagcggctgg tgagccccca gcacacggac tggctggtgc ggttcggttc ctgacggggt
    13621 gccgggtggg cgcgtcagct ccgcaggacg cccgagctcc acaggacgcg gaccgggacg
    13681 cccgtgcgcc gggcgtacgc caccacgtcg gccgtgccgc ccagcccccg ggccggctgc
    13741 ccgtcccaga cggcgaccag ccggtccgcg tggtcgacga tccagcggcc cgccgcgtag
    13801 tacgcctcct cgtgcgtcgg ttcgacgggc agatccacgc gcgccgtaca ggacttgagg
    13861 agcctgcggt acgacgcctg cacctcgtcg ccgccgagat gggcctcgta gtccatgccg
    13921 gggatcacgg cggtcagcgg gacgccgctg tccagggcga ggtcggcgaa gagctggtcg
    13981 gcgccggccg cgaggcagct gagcgcctcg acggcggcgt gacggcggag ttccccggtg
    14041 atgcccgcga gcacggcggg caggacgacg gcggggatcc ggcgatgccc ggtgacgccg
    14101 atccgagtca cgagaaccac ctccgcggcc gcggtcgtcg tccaactcac cctagcggcg
    14161 ggggcccggt acggcgacgt acgttcgccg ggtgccgggg gctcgtggga gtgacggcgc
    14221 ggcgacggtc gtacgcgcgg cgcacccgcc gggccgcgcg gggctcagag agggtactgc
    14281 caggtgaccg tggtgccggt gccggtgccg gtgccggtgc cgcgcgaggc gccgtcgccg
    14341 tgctcggccg cccggccgtc gttctccggc accccctcgc gctccttcgg caccccttcg
    14401 tggtcgtccg gcaccccgtc gtcgtgcacc gtcagccgga cgccggcgcg gccgtccggg
    14461 agggtggccg tcgcgtcgac cgtgacctcg acgcgggcga cgcccgggcg gtgggacgcg
    14521 gcggccaggg cgcggcgcag cgcggcgagg agatgaccgg cgaccgcctc cgggaccagg
    14581 ctgtccaccg ggccgatgaa ccgcgtgctc ggccggaacc ccggcacccc ggccgcgccc
    14641 gccgtctcgc gcagcacctt gccgcggaac gtggtgggcg cgtcggcggg cggctgctgg
    14701 agcgcgaaga tcgccgtacg gacctcctgg acggtggacc gcagggcgtc gaccgcccgg
    14761 ccgagcgtct cgtgcacgtc ctcctcggcg gcccggcgct gggtggactc cagcatcatg
    14821 ccggtcgcga acagccgctg gacgaccaga tcgtggagat cgcgggcgat gcgatcgcgg
    14881 tcctcgtaca ccgccagccg cttccggctg tgccacatgt ccgcgaggac cagcgccagc
    14941 gcggcctgcg aggcgaactg cgcggcgagc tgctgttcga ccggggtgta cgggcggccg
    15001 ccgcggcggc gggggagcgc gagcgtgccg atgagccggc cctccgcttc gagggggagc
    15061 atcatgctgg gcccgaaccg gtgccgtacc cgcgtcgtca tacgcgggtc ggtcgccgtg
    15121 tcgtcgatga acaccgcttc cccgccgagg agttgggcga ggaccgggct gcccggctcg
    15181 atggtcgtac cgacgatgtc gccggggtcg tcgggcgtgg acgccgtgac gatctccatg
    15241 ccgccctcgg gggtgggctt caggatgacc ccggcggccg cgccggcgag gatccgggcc
    15301 cgctcggcga ccgtcatcag cgcgtcggtg gcgttctggc cggtgagcag cgcggtggtg
    15361 acggcggcgg cgccctcgat ccaccgttcg cgctgccggg ccgtcgcgta cagccggacg
    15421 ttgtcgatgg cgatgcccgc ctgggcggcc aggacgcaca gcatccgttc gtccttgtcg
    15481 gtgaaggggc cgccggactt gccggtgagg tagagggtgc cgaactcctg gtcgtggacg
    15541 tggatcggga cgccgagcca gtcgtcaccg cggccggggc gggccggacc gtggggtgcc
    15601 gggccgcccc gcgccggtcc cgcccggtgc acccgggcga gttcttcgtg cccggggtcg
    15661 gccgtcgcga gcgccgcgta ccgggcgccg gtcagctcgg cggcgctgtc cacgatgtgc
    15721 tggagcgtgg gctccagttc gaggtcggtg cccacgccga ggacggccct cagcaggggg
    15781 acgggcaggc ggggaaccgt ctccatcggc gggaccgggg tcggggcgcg gcgtcagccg
    15841 gcgacccgtt cgaggagcag cggctcgatc cggccctcca gcatggcccc gagaccctgt
    15901 atggcgcata cgtcgggccg ctcggcgatg gacaccggca taccggttgc ctgccgcagc
    15961 atctggtcga gccccggcag cagggcactg ccgcccacca tcatgatccc gcggtcggcg
    16021 aggtcggcca ccaggtcggg cgggcagtcc cgcagcacct tgccgatgcc gtcgagcacg
    16081 gccgtgagcg gggtctggat ggcgttgcgt acggcggcgg tgtcgaccag cacggaacgg
    16141 gcgagcccgg tggccacgtc gcgtccgtgg atctcggtcg aggtcggccc gtggggcgtg
    16201 agcccgttcc cggacaaggc gatctggagc ggccgtacgg actgactcgg cagcatcagc
    16261 tcgtgctggt gccgcagatg ctgcacgatc gcgtggtcga cggcctcgcc gcccacgggg
    16321 atccggtcgg cggtcacgat ggaccccagc gacagcaccg cgatctgggt ggccgcggcc
    16381 ccgcacacca tgatcatcga cgcctcgggc cgctcgacgg gcagcccgca ccccacggcg
    16441 gcggcgacga gcgtgtcgac cagttcgacc cgccgcgcgc cgagcccgac cagcgtctcg
    16501 atcgtcgcgc gctgggccag cggatcggcg tcgtgcgggg tgcaggcggc ggcccgcagc
    16561 cggggcttgc ggcgcagggc acggcggagc ttctcgccga gcagatgacg cagcatgcgc
    16621 tgggccatct cgatgtcgac gacggtaccg ccggacacgg gccgcacgac ccggatgtat
    16681 gcgggcgtac gccccgtcat cttctcggcg aactccccga ccgcgatcag cgcgccggtc
    16741 cgcgtgttga tcgcggcggc actcggctgg tccacgacca gcccggcgcc cttcacatag
    16801 acacgggtcc tggcggcccc gaggtcgacg gcgaagtgac agcggcgcag tcggtccaga
    16861 ctgacggtca tggcggttcc tcccgagagt gcggaccgtg gggctccgcc gggcggcggt
    16921 cctctctggc atcgtgcggt cgcggacggg gcgtcgccct ttgtgggggg ccgggtgggg
    16981 ggccgccgga cgggtggatc ggccgggccg ccggaccggg gggacccacg cgtcgggccc
    17041 gcggctgcgc ggatacgcct ccaccgcgcg cgtacggcgc ggccaggggc cgtcgaagcc
    17101 gaggatcaca ccgtcggcgt gttcagtgac acgctccggc ggagggcgta cccgggcagc
    17161 ggcatgtccg ctcagcaggc cgtcgagggc ggcggtgggc ccgggacagg tgtgagcgga
    17221 agtgcgtgac ggcgagccgg cggatgcccg tcagcggggg gcgccccatt ggcacggacg
    17281 gcactcgggg ctgtcccggt ttccgctcgt accccgccgc cctggcggaa agccgccagg
    17341 gcgccttccc gccaggtccc gtcaactccc ttgccgcaca agccccccga cactcttcgc
    17401 agcacccggg cccggcgccg acgaagagag ggcatcgatg accagaggac cagcgagacg
    17461 cggggcggca ctgctgtcgg ccgggctcgt gttcgccctg ctgcccatgg ggcgggcggc
    17521 cgcgcgggac gccggcaccc cgccgtcccc gcaacccgcc tccaccgccc gcaccgtcac
    17581 ccttgtcacc ggtgacaccg tgaccgtcac cgacctcccc ggcgggaaga agaccgtcac
    17641 cgtcgagcgg ccccgagggg ccaccggagc ggtgcgcacc caggtcgtgg gcggcgccgt
    17701 cagcgtcgta cccgacgagg ccctgcccta tctgcgggcc ggcacgctcg accggcggct
    17761 gttcgacgtg agcgcgctga tccggcaggg gctcagcgat cggaagaccg gcgagacccc
    17821 gctgatcgtg ggctacggca agggcgcgcg ggccgtcaca ccgagcggtg ccaccaggac
    17881 gcgctcgctc acgagcatcg gcgccgccgc cgtcgacgcc gacaaggggc ggaccttctg
    17941 gcggtcctgg acccggcagg gcggcatcga gcacgtctgg ctcgacgcgc gggtcgaggc
    18001 cgacatggcc gagagcaacg cgcagatcgg tacgcgggcc gcgtgggacg ccgggctcac
    18061 gggcgacggc gtcaccgtcg ccgtgctcga caccggcgtc gacaccactc accccgacct
    18121 cgccggccgg gtgtcccgga gcaagagctt catcgacggg gaggaggtcg ccgaccgcaa
    18181 cggccacggg acccacgtca cctcgaccgt cggcggcagc ggcgccgcct ccgacggcac
    18241 ggagcgcggc gtcgcgcccg gtgccacgct cgccgtcggc aaagtgctca gcgaccaggg
    18301 cgcgggaagc gagtcccaga tcatcgcggg catggaatgg gccgcgcggg acgtgcgtgc
    18361 caggatcgtc tcgatgagcc tcggatcgac cgaggccagc gacgggaccg accccatggc
    18421 cgaggccgtc gacaccctct ccgaggagac cggcgccctc ttcgtcgtcg ccgcgggaaa
    18481 caccggtgcc ccctcctcga tcggctcgcc cggcgccgcc gactccgcgc tgaccgtcgg
    18541 cgccgtcgac tcatccgacc gggccgccta cttcaccagc gccggcccgc gccacggcga
    18601 caacgccctc aagcccgacc tcgccgcacc cggcgtcgac atccgcgccg cccgctccca
    18661 gctcgccccc ggcaccggct actacacctc catgagcggt acgtcgatgg cgacgcccca
    18721 tgtcgcgggg gtcgccgcgc tcctcgccga gcagcacccc gactggaccg gcgcgcggct
    18781 caaggacgcg ctgatgtcca cgtccgagca actcgacgcc tccgtatatc agttgggggc
    18841 gggtcgggtc agtgtgccgg acgccgtcgg cgcccgcgtc accgcgacgg gcagcgccga
    18901 cctcggcttc caccgctggc cccatgacgc cgatcgaccc gtcacgaaga cggtcaccta
    18961 ctccaactcc tccgacacga cggtcgagtt gagcctcgcc gtgcggggcg cgcccgccgg
    19021 tgtcgccacc ctcgccgaca ccgcactcac cgtgcccgcc cacggcaccg ccgccaccac
    19081 cgtgaccggc gacggctcca aggctccggt gggagagacg agcgggcaga tcgtcgcctc
    19141 ggccggcggc gcgcccgtcg cgcacaccgc cttcgggctg gtcaaggagg cggagcggta
    19201 ctccctcacc gtgcacgtca aggaccgcgc cggggccgcg accgccgccg gcctcgtggt
    19261 gcagcggctg gccgccggga ccgaccccta tccggcgtcc gtcggtgatt ccggcaccct
    19321 cgcgctgcgg ctcgcaccgg gaacgtacag cctgacctcc ttcctcgacg tgcgcggcgg
    19381 ccacggcgcc gactcgctcg gcctcggctt cctcgccgcg cccgagatca ccctcgaccg
    19441 ggaccgtgcc atcaccctgg acggcagcag gctgcgggag gtcgaggccg acgtcgaccg
    19501 gcgcaccgag acccggcagc tgctcatgga gtacgaccgc agcggcggcg gctccgacct
    19561 gttcggcgcc gtacaggtgc ccctcacgta cgacagcgtc ttcgccgcgc ccaccccgaa
    19621 ggtcaccgag ggcagcttcg agtaccggac cgtgtggcgg ctcgggaagc cgctcctgga
    19681 ggtcaggggg atacgggagg cggtcgtgca gtccggcggc acactgaccg aagggcgcag
    19741 ccggccgccg ctcgtcgatg tcgggtcctt caccggcggc gtgctcaccg gcgtccgggg
    19801 cagggccgtg ctcgcgcggc tcggcgacgg cgtcgagccc accgccctcg cccaggccgc
    19861 ccaggacgcc ggcgccaagg ccctgttcgt gaccgacgac agcgccggac gcctgaccgc
    19921 ctggtggggg acggacgaca acgcggaccg gccgttgcag atcgccacgg tgaacgcggc
    19981 ggacgcggcc cggctgcggg cggccggggg gaggatcgac atgaccggga cgccgaacac
    20041 gccctatgtg tacgacctct cggaaggtca ccgggggcgg attcccgacc gtgacctgac
    20101 ctatcggccg ggcaggcgtg aactcgccac agtgcgggcc aggttccacg ccgtgcggcc
    20161 ggtgggcggc ggcgagttcc ggtactcgct cacggacgcc ttccccgtcg ggatcggctt
    20221 ccgggagcgg atcgactacc cggccgagcg aacggaccac gtgtccaccg gccccggtca
    20281 gctgtggcac gagtcggtga cggtcgggga cggcacgctg gaggagcgcg gcgggctcaa
    20341 ccgctaccag ggcggggcgc acacggccct cgactggttc aagccggtct ggcatccgtg
    20401 gctcggcacc gggctcggct gggggcagga gcgctccggc gccatgatgc ggttcaacac
    20461 gcccggctgg ggggactccg ggcccgacca caccggcttc ggcgacgtgt ggagcgacga
    20521 cagcggcatg acccaggtca ccgccgtcca ccaggacggc acgctcgtcg accggcggac
    20581 cggctccggc gcctacgtgt gggacgcgcc ggccgacgag cacacctaca aggtcgtcac
    20641 ggacaccacc ctggacccgg accgctggaa gctgtccacg aagggccacg ccgagtggac
    20701 cttcaggtcc tccgccaccc ccgacgaccg ctggaccttc ctgccgctgc tcaacctcgc
    20761 cttcgacatc ggcaccggcc tcacgggcga cgtgcggggc ggcggccggg tgccggtcgg
    20821 gctcttcgcc tcctacgtcg cgggcgcccc ggacaccggg accatcggcg ccgggcacct
    20881 cgaagtgtcg tacgacgacg ggacgtcctg gcagccggtc cgcctctcgg gcggcaccgc
    20941 ctcctggcac gggacgctca ccgtgcccgg caccgcccac cacatctccc tgcgcgcctc
    21001 ggcgcgcgac gaccggggcg gctcggtcga gcaggagatc atccgggcgg tgggggtgag
    21061 gtagcggcgc caccgggcac gatgccgcgt acgaccccca gggcgaccag gtcctggggg
    21121 cggacgcgga gctggtcggc ggtgccgggc gcctcctcgg gcgggcgttt gaggatcgcg
    21181 gccgccagtt cgggggctat gaccgagaag taactgtccg gcgtggccca ggtgttgccg
    21241 ggcgcggcca gggcgagcgc gccgcccgag ccgccctcgc cgatcaacag cgtggtgagg
    21301 ggcgtacggg cggtcgccac cgcgccgaac agctccgcga tcgcggcacc gacgccctgc
    21361 cgctccgcct cggcgtcgtt ggccgcacca ggtgtgtcca ccaacgtgag tacggggatg
    21421 ccgagtcggt ccgccagccg gatcagccgg gtggcggtgc ggtagccggc ggggcgggtg
    21481 gcggtgccgg tctgggcggc gtacgcgacg acccgcccgc cgtgctcgcc ggagccggag
    21541 ccggagccgg agccggagct gaagccgaat ccgcagagca tcccgtcgtc ggtgccgccg
    21601 cagcggtccc cggcgatggc ggcccggcgc gtgaagtacg cgtccaaata ggcctgcgcg
    21661 cggggtcgtt cgggagaacg ggcacgctgg acggcgctcc agccggtgtc cgggagcctg
    21721 tcggaggtgc cgagcgcggg cggaggcggc gcgggctccg tcgacggtgc cgtgagcagg
    21781 gccagccaca ggccgaccgt ctcccgcagc tcctgaggcc ggacgaccgc gtcgatcgag
    21841 cccgccgcca gctgtgcctg agccgtgtac gcggccggat ccgcgtcggg cgggcggacc
    21901 cgggagccgg cgaagccgac ctggacgccc ggcagggcca ggacgacatc ggcgcccgcg
    21961 cccagcgtgg cccagccgcc gcccgtcgtc ggatcccgca ggaccgcgag ctgcggcagc
    22021 ccggccgcgc gggtgagcgc cgactgccgt gccacgcgct ggagttgggt gagcgcgagc
    22081 atcccctcct gcatccggct gccgcccgtc gcgacgagcg agaccacggg cagccggtgc
    22141 gccctggcgt aggtgtacgc cgcctccagc cg
//
