LOCUS       NC_003155              22572 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6869385
            Orig. end                         :: 6891957
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22572
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="31"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22572
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22572
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12572](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12572)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(171..2099)
                     /db_xref="GeneID:41542768"
                     /locus_tag="SAVERM_RS29300"
                     /old_locus_tag="SAV_5680"
                     /old_locus_tag="SAVERM_5680"
     CDS             complement(171..2099)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542768"
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381854.1"
                     /locus_tag="SAVERM_RS29300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5680"
                     /old_locus_tag="SAVERM_5680"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_010987082.1"
                     /transl_table=11
                     /translation="MAGPMGRMMAGGGPDQHSMDFKGSGKRLLSQFKPERATMAGMLVA
                     VVVSVGLSVVGPKILGRATDLVFAGIIGRQMPAGATKEQVLQSMRERGEGGVADMLSGT
                     DFTPGKGIDFTAVGNVLLLALCTFLVAGLLMAVATRLVNRAVNKTVYRMREDLQSKLSR
                     LPLSYFDKRQRGEVLSRATNDIDNIGQTLQQSMGQLINSLLTIVGVLAMMFWVSWLLAL
                     VALVTVPLSFFVATRVGKRSQPHFVQQWRTTGKLNAHIEEMYTGHTLVKVFGRQEESAA
                     QFAEENEKLYEAGFKAQFNSGVMQPLMMFVSNLNYVLVAVVGGLRVASGSLSIGDVQAF
                     VQYSRQFSMPLTQVASMANLVQSGVASAERIFELLDADEQQADPVPGVRPKELRGRVAL
                     ENVSFRYDPEKPLIEDLSLKVEPGHTVAIVGPTGAGKTTLVNLLMRFYEVSGGRITLDG
                     VDVAKMSRDELRAGIGMVLQDTWLFGGTIADNIAYGAARDVTRGEIEEAARAAHADRFI
                     RTLPDGYDTVIDDEGSGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKA
                     MAKLAHGRTSFVIAHRLSTIRDADTILVMENGSIVEQGAHAELLAADGAYARLYQAQFA
                     QAVAEVD"
     gene            complement(2099..3832)
                     /db_xref="GeneID:41542769"
                     /locus_tag="SAVERM_RS29305"
                     /old_locus_tag="SAV_5681"
                     /old_locus_tag="SAVERM_5681"
     CDS             complement(2099..3832)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542769"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660575.1"
                     /locus_tag="SAVERM_RS29305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5681"
                     /old_locus_tag="SAVERM_5681"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_010987083.1"
                     /transl_table=11
                     /translation="MLIRLLRTYLSPYQKPIAVLVLLQFLQTCATLYLPTLNADIIDNG
                     VVEGDTGYILAFGGLMIGVSLVQVICNIGAVYYGARTASAVGRDIRGSVFDRVQSFSAR
                     EVGHFGAPSLITRTTNDVQQVQMLALMTFTLMVSAPIMCVGGIVMALGLDVPLSGVLVA
                     VVPVLGISVTLIVRRLRPLFRTMQERLDTVNRVLREQITGNRVIRAFVRDDYEKDRFRG
                     ANTDLTEVSLGTGRMLALMFPIVMTVVNVSSIAVVWFGAHRIDSGGMQIGDLTAFLAYL
                     MQIVMSVMMATFMFMMVPRAEVCAERIQEVLDTSSSVVPPTAPVVELRRHGYLEIRGAG
                     FRYPGAEEPVLKAIELTARPGEVTAVIGSTGSGKSTLLGLVPRLFDATDGAVLVDGVDV
                     TTLEPKLLARTVGLVPQKPYLFAGTVATNLRYGNPDATDEELWHALEVAQAKDFVERLD
                     NGLDSPVAQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYATDAALRAALARE
                     TAEATVVIVAQRVSTIRDADRIVVLDEGRVVGTGRHHELMAGNETYREIVLSQLTEAEA
                     A"
     gene            complement(3995..5446)
                     /db_xref="GeneID:41542770"
                     /locus_tag="SAVERM_RS29310"
                     /old_locus_tag="SAV_5683"
                     /old_locus_tag="SAVERM_5683"
                     /pseudo=""
     CDS             complement(3995..5446)
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542770"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379951.1"
                     /locus_tag="SAVERM_RS29310"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5683"
                     /old_locus_tag="SAVERM_5683"
                     /product="FGGY family carbohydrate kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGIVAGLDSSPDFTRIVVCDTDTGAVLRQGYAPHPVETEGGGRPS
                     DVDPQAWLLSLGEAASGGLLEGVQAIGVSAQQNALIPLDTQGNTVRPAIVGGDRRAQVA
                     AADLIDTLGGRQAWAEAVGCVPQAAQPVTKLRWLAKSEPDAALRTAGLLQAHDWLVWQL
                     LGRPARRTTDRGGASGTGYWSAATGAYRPDLVELALGHQALLPDVLGPSEAAGTTPEGL
                     LISAGTGETMAAAFGLGIGLGDAVVSLGASGSVMAVHPEALVDSSGMITSLADATGMHL
                     PVVTTMNAVRTLRGAAELLGVSDLEGLSDLAMKSTPGSHGLVMLPYLEGERTPNLPHTA
                     GTLAGLRRESMRPEHLARAAFEGML"
     gene            complement(5722..6036)
                     /db_xref="GeneID:41542771"
                     /locus_tag="SAVERM_RS29315"
                     /old_locus_tag="SAV_5684"
                     /old_locus_tag="SAVERM_5684"
     CDS             complement(5722..6036)
                     /codon_start=1
                     /db_xref="GeneID:41542771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660577.1"
                     /locus_tag="SAVERM_RS29315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5684"
                     /old_locus_tag="SAVERM_5684"
                     /product="hypothetical protein"
                     /protein_id="WP_010987086.1"
                     /transl_table=11
                     /translation="MRYRLTFVAGLALGYVLGTRAGRERYEQLKKAAHQVAQNPAVRNT
                     AETAALQGRQFAGKAYHTVSEKVGDHVPDSVAGRVRSLRERNANGSVRSREDDWGTSNT
                     "
     tRNA            6218..6290
                     /anticodon=(pos:6875636..6875638,aa:Asn,seq:gtt)
                     /db_xref="GeneID:41542772"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SAVERM_RS29320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAV_t55"
                     /old_locus_tag="SAVERM_t55"
                     /product="tRNA-Asn"
     gene            6218..6290
                     /db_xref="GeneID:41542772"
                     /locus_tag="SAVERM_RS29320"
                     /old_locus_tag="SAV_t55"
                     /old_locus_tag="SAVERM_t55"
     tRNA            6296..6368
                     /anticodon=(pos:6875714..6875716,aa:Asn,seq:gtt)
                     /db_xref="GeneID:41542773"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SAVERM_RS29325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAV_t56"
                     /old_locus_tag="SAVERM_t56"
                     /product="tRNA-Asn"
     gene            6296..6368
                     /db_xref="GeneID:41542773"
                     /locus_tag="SAVERM_RS29325"
                     /old_locus_tag="SAV_t56"
                     /old_locus_tag="SAVERM_t56"
     misc_feature    complement(6524..6540)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.52"
                     /tool="antismash"
     tRNA            6535..6608
                     /anticodon=(pos:6875954..6875956,aa:Ile,seq:cat)
                     /db_xref="GeneID:41542774"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SAVERM_RS29330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAV_t57"
                     /old_locus_tag="SAVERM_t57"
                     /product="tRNA-Ile"
     gene            6535..6608
                     /db_xref="GeneID:41542774"
                     /locus_tag="SAVERM_RS29330"
                     /old_locus_tag="SAV_t57"
                     /old_locus_tag="SAVERM_t57"
     misc_feature    6632..6645
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            7033..7341
                     /db_xref="GeneID:41545252"
                     /locus_tag="SAVERM_RS42495"
     CDS             7033..7341
                     /codon_start=1
                     /db_xref="GeneID:41545252"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS42495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_137865174.1"
                     /transl_table=11
                     /translation="MRVQPVEAAVCFGRHAVRDAAGGLVAVHGEYVACPAQPGDPQRMG
                     EQWKPTDLVGVGFVRSRVWVVRCRCPEVAQQALHEPRFDLQSDSAGGMQDRLPRPGP"
     gene            complement(7356..7661)
                     /db_xref="GeneID:91294979"
                     /locus_tag="SAVERM_RS45630"
                     /old_locus_tag="SAV_5685"
                     /old_locus_tag="SAVERM_5685"
     CDS             complement(7356..7661)
                     /codon_start=1
                     /db_xref="GeneID:91294979"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="SAVERM_RS45630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5685"
                     /old_locus_tag="SAVERM_5685"
                     /product="hypothetical protein"
                     /protein_id="WP_338059022.1"
                     /transl_table=11
                     /translation="MTRLDRGAADTDVLRRSLAVDDGGNGEERRLVLVVDQLEELFTLC
                     PGGRERREFLAAVLGVAAQVQTAKLPSAWSSSACAPTSTPSAPPIPGSSKRWKVIR"
     gene            complement(<7638..>7893)
                     /db_xref="GeneID:91294862"
                     /locus_tag="SAVERM_RS44975"
                     /pseudo=""
     CDS             complement(<7638..7893)
                     /codon_start=1
                     /db_xref="GeneID:91294862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067337.1"
                     /locus_tag="SAVERM_RS44975"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDLLRRQVREMARRKADPGLVVLNTQSVHAAAGAPAESTGCDAAK
                     STGPQARPGC"
     gene            complement(8148..10004)
                     /db_xref="GeneID:41542776"
                     /locus_tag="SAVERM_RS29345"
                     /old_locus_tag="SAV_5686"
                     /old_locus_tag="SAVERM_5686"
     CDS             complement(8148..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542776"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602542.1"
                     /locus_tag="SAVERM_RS29345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5686"
                     /old_locus_tag="SAVERM_5686"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_042493708.1"
                     /transl_table=11
                     /translation="MTDTVVDQTQSAAEGDRSTRAAIATMYRLTTGHRASLTLATVLTL
                     VGSALGLAQPLAAKQVVDASGRGQVLWPLLLLLAGLFVTEAATGAVGRFVLERMGEGIV
                     RGLRHSLVGRLLRLEMREYDRLRSGDLISRVTTDTTLLREVVSQALVDLLTGALVAAGA
                     IVLMAWIDPLLLLLIAATVATAAAIVASLLKGIRAASERMQTSVGAIAADLERALGALP
                     MVRVHRTEDREAGRIGECVESAYSAGVRTAKLASVMSPAVELAVQGSFLIVLVIGGLRV
                     NGHANSLGDLVAFLLYASYLVLPLSSVFRAVGLIQRGMGAYQRIEQALSLPAEPSQETP
                     TVRARTREPARQTVSYEKPALALRDIGFGYDPSRPVLRGLSFTAPHRCQTALVGLSGAG
                     KSTIFALISRFYEPDSGTLLFDGLPATELSRAACRGRIAVVDQNTHVVHGTLWDNITYA
                     APDATEAEVRRAVELAQLEGVVRRLPGGLSGMLGERGSRLSAGERQRVALARALLARPS
                     ILLLDEPTSHLDTLNETALTTVMKDVARECALLVIAHRLSTVQHADRIIVLDEGRAVAC
                     GRHEELLTSSPTYRELAAGQMLRPAATPPSPVTTARHPHSPL"
     gene            complement(10001..10435)
                     /db_xref="GeneID:41542777"
                     /locus_tag="SAVERM_RS29350"
                     /old_locus_tag="SAV_5687"
                     /old_locus_tag="SAVERM_5687"
     CDS             complement(10001..10435)
                     /codon_start=1
                     /db_xref="GeneID:41542777"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309238.1"
                     /locus_tag="SAVERM_RS29350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5687"
                     /old_locus_tag="SAVERM_5687"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_010987089.1"
                     /sec_met_domain="PF13471 (E-value: 2.6e-26, bitscore: 90.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPTGVPFARRMAARLVLSPALALSLLPPRRLRAVLHF
                     ACRGAMPATAAQAKNARDAMCAVSLRCAGPKGCLPRSLGAALLCRLGGSWPTWCTGVRV
                     VPPFTAHAWIEADGRPVDEGVPDDYFTRLITVAVASRSGR"
     gene            complement(10432..10686)
                     /db_xref="GeneID:41542778"
                     /locus_tag="SAVERM_RS29355"
                     /old_locus_tag="SAV_5688"
                     /old_locus_tag="SAVERM_5688"
     CDS             complement(10432..10686)
                     /codon_start=1
                     /db_xref="GeneID:41542778"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309239.1"
                     /locus_tag="SAVERM_RS29355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5688"
                     /old_locus_tag="SAVERM_5688"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_037645743.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 8.2e-26,
                     bitscore: 88.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8.1e-15, bitscore: 53.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKFGANVSTAETDYGTVLLDERAGEYWELNPTGTLVVNTLMAG
                     GDEAAAVVALADEFDIDLVQAKQDVDALVQQLRTSGLAE"
     aSDomain        complement(10438..10680)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SAVERM_RS29355_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="2.90E-28"
                     /identifier="RREFam002.1"
                     /label="SAVERM_RS29355"
                     /locus_tag="SAVERM_RS29355"
                     /protein_end="83"
                     /protein_start="2"
                     /score="88.7"
                     /tool="antismash"
                     /translation="LKFGANVSTAETDYGTVLLDERAGEYWELNPTGTLVVNTLMAGGD
                     EAAAVVALADEFDIDLVQAKQDVDALVQQLRTSGLA"
     gene            complement(10716..12572)
                     /db_xref="GeneID:41542779"
                     /locus_tag="SAVERM_RS29360"
                     /old_locus_tag="SAV_5689"
                     /old_locus_tag="SAVERM_5689"
     CDS             complement(10716..12572)
                     /codon_start=1
                     /db_xref="GeneID:41542779"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656043.1"
                     /locus_tag="SAVERM_RS29360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5689"
                     /old_locus_tag="SAVERM_5689"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_037645488.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.2e-48, bitscore:
                     165.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELHESAGTGPGDAHFTVFTDREDATAVARSFARPGTRILQHAS
                     GRPWLVGQWHDQEIVTARAGHTALAVIGCCPIDAVELERQAGRLRDLAELDALARSLPG
                     SFHLVAALDGRLRVQGTASGLRLVFHAPVDGTQVAATRADVLAAALGTDPDEEQLAIRL
                     LWPVPHTLAEAPMWRGITAVSPQDALIISPDGRTVRRSRWWTPPEPVRTLADGAPLVRE
                     ALAAAVDARTRQGGVVSCDLSGGLDSTSICFLADRSPARVVASTWPGRDPADTDLYWAE
                     QAARSLPEIDHVVWDADTSPLVYTGLLDIDDLLDEPTIGVMDRSRVLHHLPGLAERGSR
                     LHLTGIGGDHVAWCSEAYYHRLLRTRPLFALRQLRGFRALWQWPLGGTARALADSRPYG
                     KWLADSSGRLRDPLPATVSTSLGWGMPPRLFDWVTADAERMAQRALREAAMTAVPLHPD
                     RGLHTDLEQILSCTRIIRQWDRMAARAGVPMASPFLDDRVIEACLAVRPSERVTPWQYK
                     PLLTAAMSGIVPDACLRRTNKAAASMDASNGLREHRADLLALWEGSRLEQLGLVDGTAL
                     RRLAQRPATPELRDAILYSTIAAEVWLRGLHRTSEPKAPASS"
     gene            complement(12599..12709)
                     /db_xref="GeneID:41545135"
                     /locus_tag="SAVERM_RS41905"
                     /old_locus_tag="SAVERM_7585"
     CDS             complement(12599..12709)
                     /codon_start=1
                     /db_xref="GeneID:41545135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656044.1"
                     /locus_tag="SAVERM_RS41905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAVERM_7585"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107082950.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGTFRKKTGLLGRSGNDRLILSKN"
     misc_feature    complement(12886..12902)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.95"
                     /tool="antismash"
     misc_feature    complement(12931..12944)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.35"
                     /tool="antismash"
     misc_feature    12978..12992
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.41"
                     /tool="antismash"
     misc_feature    13129..13142
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.61"
                     /tool="antismash"
     misc_feature    complement(13130..13143)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.42"
                     /tool="antismash"
     misc_feature    complement(13137..13151)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    complement(13139..13150)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.59"
                     /tool="antismash"
     gene            complement(13365..13955)
                     /db_xref="GeneID:41542780"
                     /locus_tag="SAVERM_RS29365"
                     /old_locus_tag="SAV_5690"
                     /old_locus_tag="SAVERM_5690"
     CDS             complement(13365..13955)
                     /codon_start=1
                     /db_xref="GeneID:41542780"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS29365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_5690"
                     /old_locus_tag="SAVERM_5690"
                     /product="hypothetical protein"
                     /protein_id="WP_052082295.1"
                     /transl_table=11
                     /translation="MTDTAAQVVAAVFDQAEHRDTGHRRCWDVLVDGARHQIDLLKAEA
                     LQRSVDVHIIVDLIHVLEYLWRAAWCLHDSISTAALEKAAHAAGQRGTQRKSIDEAMNY
                     LSGKAEHLRYDTALERGWPISTGIIEGACRHLVKDRLDITGARWGLSGAETVLKLRAVR
                     ANGDFVASWAWHQQQESIHNHQTRYRDQAITTA"
     gene            complement(13952..14263)
                     /db_xref="GeneID:41545253"
                     /locus_tag="SAVERM_RS42500"
                     /old_locus_tag="SAV_5691"
                     /old_locus_tag="SAVERM_5691"
     CDS             complement(13952..14263)
                     /codon_start=1
                     /db_xref="GeneID:41545253"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS42500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_5691"
                     /old_locus_tag="SAVERM_5691"
                     /product="hypothetical protein"
                     /protein_id="WP_137865172.1"
                     /transl_table=11
                     /translation="MPAPCTDTTPLILSVDGKGMMMRPEALREDTARAAAAKGGNAMKT
                     RLASGEKHGRKRMATLGAVYDAEPAPRTVDDGKTTPSAARRPSAARGRRPGRSGCAAR"
     misc_feature    14646..14662
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.91"
                     /tool="antismash"
     gene            14688..14921
                     /db_xref="GeneID:41542781"
                     /locus_tag="SAVERM_RS29375"
                     /old_locus_tag="SAV_5693"
                     /old_locus_tag="SAVERM_5693"
     CDS             14688..14921
                     /codon_start=1
                     /db_xref="GeneID:41542781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067000.1"
                     /locus_tag="SAVERM_RS29375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5693"
                     /old_locus_tag="SAVERM_5693"
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_010987095.1"
                     /transl_table=11
                     /translation="MSVTQIDLDDEALAEAMRLMGVTTKKETVNAALRDYVARIKRLDA
                     AEKLAARGARGEFEQAAAAYYAGKRARREAFE"
     gene            14918..15325
                     /db_xref="GeneID:41542782"
                     /locus_tag="SAVERM_RS29380"
                     /old_locus_tag="SAV_5694"
                     /old_locus_tag="SAVERM_5694"
     CDS             14918..15325
                     /codon_start=1
                     /db_xref="GeneID:41542782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987096.1"
                     /locus_tag="SAVERM_RS29380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5694"
                     /old_locus_tag="SAVERM_5694"
                     /product="PIN domain nuclease"
                     /protein_id="WP_010987096.1"
                     /transl_table=11
                     /translation="MITYLLDTSALWHLFRTPGALAPWEGHIAAGVFHLCEPTRAEFLY
                     SATSPTHRDELAEELDALCLLSPVPKNAWRWVDTAQYKLTQQGQHRAAGAIDLLVCATA
                     VHHGHTVLHVDNDFATVAGVLKELQQRDVRA"
     misc_feature    15617..15628
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            16323..18266
                     /db_xref="GeneID:41542783"
                     /locus_tag="SAVERM_RS29385"
                     /old_locus_tag="SAV_5695"
                     /old_locus_tag="SAVERM_5695"
     CDS             16323..18266
                     /codon_start=1
                     /db_xref="GeneID:41542783"
                     /inference="COORDINATES: protein motif:HMM:NF012570.4"
                     /locus_tag="SAVERM_RS29385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5695"
                     /old_locus_tag="SAVERM_5695"
                     /product="dynamin family protein"
                     /protein_id="WP_048894205.1"
                     /transl_table=11
                     /translation="MTEQLVVDGPGAGWTSVVTGHLRWIEGLLDSLGLPAERSDELRAR
                     LLAVQARAADPQLRVAVFGETSSGKSTLLNAFLRRRLLPSSALVTTRTTTVLEYREGAE
                     GLMVSTTDDSVLEWPSAPFAGWAGRGRESGPDTLERALRRVLTTALADEVGSLRVLSPV
                     RLLGPGVTVIDTPGFSVTERGHRELAEAAARQADVALVVVPAVAAMSLTLVDFLTGPLR
                     DHHDRCAFVLTKLDLLDEDERSEAVEVVERRLRDLGCADPLLLPCSPGKALGEVTAVGV
                     REPGGSGHLASFLEVEARIARLAADSRRSAVAATVLGLLSELLSAVEETAEARRAALSR
                     GERELAALTLPDLPAFLDAWAARTRDRARTELNAATLTRTSAQSRTTLEVKVGNTVAGE
                     KINDLAGAAEEVSRLVRRHLRRDAQQAVRTAVKRAGEVLTAAAEELARDFAAQYSVLTD
                     LAGEARTAPPVPQVVWPEPPAPDMSGIDRALTAIGTQLTSSGNWRTGGGAMAGALAGSL
                     VAPGIGTVIGGALGALIGRRGPDATREQFLRQARPVIAAAHDEIGALAAACLPRVAEGL
                     SDSVAALRRQYDEEWRDEIARLTAAHDRRRAELAAGIAHAEKTATDARRRRDAVASLRR
                     ETSRTVPDLKES"
     misc_feature    17577..17579
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18270..20126
                     /db_xref="GeneID:41542784"
                     /locus_tag="SAVERM_RS29390"
                     /old_locus_tag="SAV_5696"
                     /old_locus_tag="SAVERM_5696"
     CDS             18270..20126
                     /codon_start=1
                     /db_xref="GeneID:41542784"
                     /inference="COORDINATES: protein motif:HMM:NF012570.4"
                     /locus_tag="SAVERM_RS29390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5696"
                     /old_locus_tag="SAVERM_5696"
                     /product="dynamin family protein"
                     /protein_id="WP_010987098.1"
                     /transl_table=11
                     /translation="MSSASRSEAGPPPAADPSAHVGDVGATASGSLREARRLAEDYGQD
                     HIREALDLLAAGRGRPAFRIAVVGEFNRGKSTLINRLLGRDLLPTGSLPVTRAPVVIRV
                     SDAEGLTLGRPDGRRELRKLDDDTLWDGLTGPPAEREPGAPAGPPEPTVTLAVADDWLA
                     GLDAEVVDTPGVNSGTEEQFEQVRRTAAGSDAVLFVVSALSPMSITERRLLEEEVLCRH
                     VPFVAVVVTMLDLVDGDDREESVRDLKNRLSGLAGLPVLIAPVPGGGESELAALRVLLE
                     GFARDSERALWRDRGIAAQVADHCEAMARIAAEADAVGRLPEEEVAERARLAQALRESE
                     DRQWEQLRTDMTGRQLHLGARLREHVQKGRDGIIERLRWDLERASEPGTWWERDLPVRL
                     GHELSLLARSSERTVLLPAMAADTDWLDREVARRLPGAARSPLPATLELSTDPDISGEV
                     SSLSRTRLVTRLGAQGGSILGFLIAATRQGPRSDSDRSGPPPMVYSSVLSLVGGLLAEA
                     YVRNATEEQRRQVDAVLVRAVDESAGVFQRRAVDALGDVYADMFARLRESHQAWADARR
                     AAVESTSASGTDWPSLASAAAELAAGIRSALADGVRAEEEQE"
     gene            20150..22102
                     /db_xref="GeneID:41542785"
                     /locus_tag="SAVERM_RS29395"
                     /old_locus_tag="SAV_5697"
                     /old_locus_tag="SAVERM_5697"
     CDS             20150..22102
                     /codon_start=1
                     /db_xref="GeneID:41542785"
                     /inference="COORDINATES: protein motif:HMM:NF045159.1"
                     /locus_tag="SAVERM_RS29395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5697"
                     /old_locus_tag="SAVERM_5697"
                     /product="dynamin family protein"
                     /protein_id="WP_159029004.1"
                     /transl_table=11
                     /translation="MTTVEGGYAAAAEQRLRLAEMCRRTEKAAEQIGNNGAVRDVTALL
                     ERIENEAFHVMVVGDFNRGKSTFVNALLGDRVLPVKAVPATAVITEVRFGESPAALLWT
                     ADAAEPEAVDPDRLIELITVNNASADERSPYVKAEVVWPLELCRHNVVLIDSPGLNAYE
                     THDDITLTHLSKADAVIFLQHAIAPMSISESTFLKKYLSAHDPFFVFTYFDAIDDHERD
                     DVTASARRRVTDLRGEDRDRSRFFFVDGKSALRARMAEDDEAFRRTGVEAVERELERYL
                     VTERHKVKLLAPARSVRGVARELRRNIPSELQMLEAESGDLERNWAAAQQPLRELEAQA
                     QQITLDIRNETRVLQDRVETLLGGFLAAVADEAPLVAQDVEITTKLGLNLLKAKVRAQQ
                     VAEEIAGGTAKAMEEKVALWVGESLKPVIEQDLERLAERMNAELTSFEAALEKLRIDLH
                     GASGAADAGEGREDEPLTKFLAGLGGFVLSGPAGALVGARFGAKEALRTFLPAFAIGAA
                     WALTPFGLPVLVAALIGQGLFQGKGAGERVEKKMREEIGRAMATQLRLAAPKEAQKAAR
                     AFAADTMEPMQREITQGMSFRIEELTRSVASARQVLDQGEEAVERRRGELNRLDGLLGR
                     ADDEIGDLVAELTRM"
ORIGIN
        1 cccgcacact ggaggagatc gggcgcatct tcggcgtcac gcgtgaacgc atccgccaga
       61 tcgagtcgaa gaccctgaac aaactccgcg accacgcgtt cgcggaccag ctgcggggct
      121 acctggactg aaagggggcc gccgtgcggc ggccccctcg gcccaggagg tcagtccacc
      181 tcggccacgg cctgcgcgaa ctgcgcctgg tacagccgcg cgtacgcccc gtccgcggcg
      241 agcagttcgg catgcgcccc ctgctcgacg atggacccgt tctccatcac caggatcgtg
      301 tcggcgtccc ggatcgtcga cagccggtgc gcgatcacga acgacgtacg gccgtgtgcg
      361 agcttcgcca tcgccttctg gatgagcacc tcggtacggg tgtcgaccga gctggtggcc
      421 tcgtccagga ccaggatcac cgggtcggac aggaacgccc gggcgatcgt gatgagctgc
      481 ttctcacccg cgctcacccc ggacccctcg tcgtcgatca cggtgtcgta gccgtccggc
      541 agcgtacgga tgaaccggtc ggcgtgcgcg gcgcgcgccg cctcctcgat ctccccgcgg
      601 gtgacgtcac gcgcggcgcc gtacgcgatg ttgtccgcga tggtgccgcc gaacagccag
      661 gtgtcctgga gcaccatccc gatcccggcc cgcagttcgt cccgcgacat cttcgcgacg
      721 tcgaccccgt cgagcgtgat ccgcccgccg ctgacctcgt agaaccgcat gaggagattg
      781 accagcgtgg tcttgccggc gccggtggga ccgacgatcg cgaccgtgtg ccccggctcc
      841 accttcagcg acaggtcctc gatcagcggc ttctcggggt cgtaccggaa cgaaacgttc
      901 tccagcgcga cccggccccg cagctccttc ggacgcacgc ccggcaccgg gtcggcctgc
      961 tgctcgtccg cgtcgagcag ttcgaagatc cgctcggcgg aggcgacgcc cgactggacc
     1021 aggttggcca tcgacgcgac ctgcgtgagc ggcatcgaga actgccgcga gtactggacg
     1081 aacgcctgca catcaccgat cgacagcgag ccggacgcga cccgcaggcc accgaccacg
     1141 gccaccagca catagttcag gttcgacacg aacatcatca gcggctgcat gaccccgctg
     1201 ttgaactgcg ccttgaaacc ggcctcgtac agcttctcgt tctcctcggc gaactgcgcc
     1261 gccgactcct cctgccgccc gaacaccttc accagcgtgt ggccggtgta catctcctcg
     1321 atgtgggcgt tgagcttgcc ggtggtgcgc cactgctgca cgaagtgcgg ctgcgaccgc
     1381 ttaccgacgc gggtggcgac gaagaaggag agcggcacgg tgaccagcgc cacgagtgcc
     1441 agcagccacg acacccagaa catcatcgcc agcacgccga cgatcgtgag cagcgagttg
     1501 atgagctgac ccatcgactg ctggagcgtc tgcccgatgt tgtcgatgtc gttggtcgcc
     1561 cggctcagca cctcgccgcg ctgccgcttg tcgaagtacg acagcggcag ccgcgacagc
     1621 ttcgactgca ggtcctcgcg catgcggtag acggtcttgt tgacggcccg gttcaccagc
     1681 cgggtggcga ccgccatcag caggccggcc accaggaacg tacagagcgc gagcagcagt
     1741 acgttgccga cggcggtgaa gtcgatgccc ttgcccgggg tgaagtccgt ccccgagagc
     1801 atgtcggcga cgccgccctc gccccgctcg cgcatggact gaaggacctg ctccttggtg
     1861 gccccggcgg gcatctgccg cccgatgatc cccgcgaaga ccaggtcggt cgccctgccg
     1921 aggatcttcg gtccgaccac cgagagcccc acgctcacga ccacggcgac cagcatcccc
     1981 gccatggtcg cgcgctcggg cttgaactgg gagaggagcc gtttgcccga ccccttgaag
     2041 tccatcgagt gctgatcagg gccgcccccg gccatcatcc gccccatcgg ccctgccatc
     2101 aggcagcctc cgcttccgtc agctgggaga gcacgatctc ccggtaggtc tcgttgcccg
     2161 ccatcagctc gtggtggcgg ccggtgccga cgacgcggcc ctcgtcgagg accacgatcc
     2221 ggtcggcgtc ccggatggtc gacacgcgct gggcgacgat cacgacggtc gcctcggcgg
     2281 tctcgcgcgc gagcgccgcc cgcagggccg cgtcggtcgc gtagtcgagc gcggagaacg
     2341 agtcgtcgaa gaggtagatc tccgggcgct gcaccagggt gcgggcgatc gcgagccgct
     2401 gccgctgacc gcccgacaca ttcgtgccgc cctgcgcgac gggggagtcg aggccgttgt
     2461 ccagccgctc cacgaagtcc ttggcctgcg ccacctccag cgcgtgccac agctcctcgt
     2521 cggtcgcgtc cgggttcccg taccgcaggt tcgtggcgac ggtgcccgcg aagagatacg
     2581 gcttctgcgg tacgaggccg acggtcctgg cgagcagctt cggctcgagg gtcgtcacat
     2641 ccacaccatc gacgagcacg gcgccgtcgg tggcgtcgaa cagccggggg accagcccca
     2701 gcagcgtgga cttgccactg ccggtcgacc cgatgacggc ggtcacctcg ccgggccgcg
     2761 ccgtcagctc gatggccttg agcaccggct cctcggcacc cgggtagcgg aacccggcac
     2821 cccggatctc caggtacccg tgccgccgca gctcgacgac gggcgcggtc gggggaacga
     2881 cactgctgga ggtgtcgagg acctcctgga tgcgctcggc gcagacctcc gcgcgcggca
     2941 ccatcatgaa catgaaggtg gccatcatca cggacatcac gatctgcatc agataggcga
     3001 ggaacgcggt caggtcgccg atctgcatgc cgccgctgtc gatgcggtgc gcaccgaacc
     3061 agaccacggc gatcgacgac acgttcacca ccgtcatgac gatggggaac atcagcgcga
     3121 gcatgcgccc ggtgcccagg gacacctcgg tgaggtcggt gttcgcgccc cggaagcggt
     3181 ccttctcgta gtcgtcgcgg acgaaggcgc ggatgacacg gttgccggtg atctgctcgc
     3241 gcagcacccg gttcacggtg tcgagccgct cctgcatggt ccggaacagc gggcgcagcc
     3301 ggcgcacgat cagcgtcacg gagatgccga gcaccggcac cacggcgacc agcaccccgg
     3361 acagcggcac atccagaccg agcgccatga cgatgccgcc cacacacatg atcggcgcgg
     3421 agaccatcag ggtgaacgtc atcagggcga gcatctgcac ctgctgcacg tcgttcgtcg
     3481 tgcgggtgat cagcgagggc gccccgaagt ggcccacctc acgcgcggag aacgactgca
     3541 cccggtcgaa gacgctgccc cggatgtcgc ggccgaccgc cgaggccgta cgggcgccgt
     3601 agtagacggc gccgatgttg cagatgacct ggaccagcga gacgccgatc atcagtccgc
     3661 cgaaggcgag gatgtagccc gtgtccccct ccacgacacc gttgtcgatg atgtccgcgt
     3721 tcagggtggg cagatacagg gtggcgcagg tctgcaggaa ctgcagcagc accagcacgg
     3781 ctatgggttt ctggtacgga ctgaggtagg tacgaagcaa tcgtatgagc acgcggggtc
     3841 tctcggagtc gtcggcgaca gggcgggtag tggtgcacca ccccctatcg tcgaacactc
     3901 cacccgtgtt acctcaactg attaacccaa gtgcggtcca agaacggaca ggcgtcagcc
     3961 ccgagacgta ggaccgtgcc cctccgttcg ccccttatgc cctgaacgcc cccggatggg
     4021 tctgttcgcg caccgacacg tactgctgcc gtacggcctg ccccaccgcg agttcctcgc
     4081 ccggctccag gacctgggcg gccgcgccct gccacacggg cggggccccc ggggagagcg
     4141 tgccctggga gacgccgagc gcccaggccg cctgccgggc cgcgccgatc gccgcgtagt
     4201 cggccggctg ggggacgacg acctgcacgc cgaacagcgc cggcgccgcg gcctgcacgg
     4261 cggccagctc cgccgccgcg ccgaggagga agatccgccg tacgtcgacc ccgcgcccgc
     4321 gcagcacgtc cagcgcgtcg gcgagccctc acagcatgcc ctcgaacgcg gcccgcgcga
     4381 ggtgctcggg ccgcatcgac tcccggcgca gccccgccag cgtcccggcg gtgtgcggca
     4441 gattgggcgt ccgctcgccc tccaggtacg gcagcatgac gagcccgtgg gagcccggcg
     4501 tcgacttcat cgccaggtcg gacaggccct ccaggtcgga cacgccgagg agttcggcgg
     4561 caccgcgcag cgtccgtacc gcgttcatcg tggtcacgac cggcagatgc atgccggtcg
     4621 cgtcggcgag cgaggtgatc attccggagg agtcgaccag cgcctcgggg tggacggcca
     4681 tcacggatcc ggaggcgccg agcgacacca cggcgtcccc gagcccgatc cccagcccga
     4741 aggccgccgc catggtctcg ccggtcccgg cggagatcag cagcccctcc ggtgtcgtac
     4801 ccgccgcctc ggacggcccg agcacatcgg gcagcagcgc ctggtgcccg agcgccagct
     4861 cgacgagatc tggccggtat gcgccggtcg ccgccgacca gtacccggtc cccgaggcgc
     4921 caccgcggtc ggtggtcctg cgcgccggcc gcccgagcag ctgccacacg agccagtcgt
     4981 gcgcctggag cagtccggcg gtgcgcagcg cggcgtcggg ctccgacttg gcgagccagc
     5041 gcagcttggt cacgggctgc gcggcctgcg gcacgcagcc cacggcctcg gcccatgcct
     5101 gacgcccgcc gagcgtgtcg atcagatcgg cggcggcgac ctgtgcgcgc cggtccccgc
     5161 cgacgatcgc gggccgcacg gtgttgccct gggtgtccag cgggatcagc gcgttctgct
     5221 gcgccgagac gccgatggcc tgcacgccct cgagcagccc gccgctcgcg gcctcgccca
     5281 gggacagcag ccaggcctgc ggatcgacgt cggagggacg cccgccaccc tcggtctcga
     5341 ccgggtgcgg cgcatagccc tgcctgagta cggcccccgt gtccgtgtcg cagacgacga
     5401 tgcgagtgaa atcgggcgaa ctgtccaacc cggcgactat ccccatggcg gaaattctgc
     5461 cgtacggaga gaggtgggcg tgcagcgcgg acagacgggg cggcgcgggg cggccggtgg
     5521 gggcggtgcg gcgcggctgg tgggggtggt gcggggcggg ctggggtggc ggtgcggcgg
     5581 gggctgaggt ggcgttgccg cgggctgggg tggtggtgcg gcgggggcag aagcggcggt
     5641 gcggcgcggg cagaggcggc ggtgtggtgc cgcccgcttg cctctctccg cgccgccccg
     5701 ccgggtgttg tcggcgtccc gctaggtgtt actggtgccc cagtcgtcct cgcggctgcg
     5761 gacgctgccg ttcgcgttgc gctcccgcag ggagcgcacg cggccggcca cggagtcggg
     5821 gacgtgatcg cccaccttct cgctcaccgt gtggtacgcc ttgccggcga actggcggcc
     5881 ctgaagggcc gccgtctcgg cggtgttgcg caccgccggg ttctgcgcga cctgatgtgc
     5941 ggccttcttc agctgctcgt agcgctcgcg cccggcacgc gtgccgagca cgtaaccaag
     6001 agccagtccg gcgacgaacg tgagccggta gcgcatggcg gccacccttt cccttgtgta
     6061 ggtccctggt gtcggcatcg atgatcggcg gtcggtcatc gggtgcgggg agtaccgatt
     6121 ggcggagcac ccccctgctt gcgctaatgt atgtgtcgca gagagcgcgc gccccctggc
     6181 gaatacccag gtaggtgcgt tcgatgcaac gaggcattcc tccgtagctc aattggcaga
     6241 gcagccggct gttaaccggc aggttactgg ttcgagtcca gtcgggggag ctcggtcctc
     6301 cgtagctcaa ttggcagagc agccggctgt taaccggcag gttactggtt cgagtccagt
     6361 cgggggagca gcctgaagag gacccttagg ggtccttttt catgtccggg ggaaccgcgc
     6421 aggccacggc gaagtcctca tggtcatgcg aagtcgacca tccgaagcag gagatcgtat
     6481 gagcggctat gctgcggcag acggcgcgca cacatgtgcg cgacgcgccg taatggggcg
     6541 gtagctcagc cggttagagc agcggactca taatccgtcg gccgtgggtt cgagtcccac
     6601 ccgccccacc tgtgcaggtc tttgacctgc ggaaacgttc atttttgggt gtctgtccgt
     6661 caactttgcc tgaacggact gaatccgctg ctcgtgggtt tggagtccgg aggctcgggg
     6721 gagccgtaaa acctctgacc tgcggcggag taggtgttcg aggttcccgc tcgcggtgcg
     6781 ggcggccgcc ctgagggact ggtgccaaga ttccaggggc cgtacagggg ccgggagggc
     6841 gcggccgtgg ccaggctcat ggtttctccg ggctgattcg gccgccgcag tcgcggaact
     6901 gcagaagatc gccaccgccg gccgaccggc cagcaccgcc cacccatgcg ctgaccggac
     6961 ccgcgagcgc caccaggccg tgcacgccct gctcgaccag agccgcgcct cggactgtgc
     7021 ggtgcgctgc gcgtgcgggt acagcccgtc gaagcggcgg tctgcttcgg ccgtcacgct
     7081 gtgcgcgatg ccgccggtgg actcgtagcc gtccacggtg agtacgtggc ctgcccggcg
     7141 cagccaggtg acccgcagcg catgggcgag cagtggaagc cgaccgatct cgtaggcgtc
     7201 ggcttcgtcc gttcccgggt gtgggtggtc cggtgccggt gccccgaggt cgcgcaacag
     7261 gctctgcacg agccccggtt cgacctccag tccgacagcg cgggcgggat gcaggatcgc
     7321 ctcccgcggc ccggcccgtg acagcggccc gacgatcacc tgattacctt ccaccgcttc
     7381 gaggagcctg ggatgggtgg cgcactgggt gtagaagtcg gagcgcaggc cgaagatgac
     7441 caggccgacg ggagcttcgc cgtctgcacc tgggccgcca cacccaggac cgcggccagg
     7501 aattcccgcc gctcccgccc gccggggcac agcgtgaaca gctcctccag ctggtccacg
     7561 accagcacca ggcggcgttc ctcaccgttc ccgccgtcgt ccaccgcgag tgagcgccgc
     7621 agtacgtcgg tgtcggcggc gcccctgtcc agccgcgtga tcccgacggc gttctcgtgc
     7681 gccgacgcgg ccaccacgac caccgcgatc accagcccca gaacatcaac agccaggccg
     7741 cgcttgcggg ccggtacttt ttgccgcatc acaccccgtc gactctgcgg gcgcgccagc
     7801 cgccgcgtgc acgctctggg tgttgagcac caccaggccc gggtccgcct tccgacgcgc
     7861 catttcccgc acctgccggc gcagcaagtc gtgcgggagc agctcccact ggctgccgca
     7921 ccgccacacg ttcaggtgag gaaaaaattc ctatgcactc tcttaccgcc ctctcagagg
     7981 gcggtaagag acgtgttgcc cgtttcgtgc ttgcggctgg ggctgtcggg ctggtggtgg
     8041 tctttgtgtg tggctatggc cgtggctggg tgaacaaccc ccatcacgcc tcgccccccc
     8101 gaaccatcga gtacccacac tggctcagcg cggaaagctc gcccggttca cagtgggctg
     8161 tgcggatggc gcgcggtcgt cacgggggag ggcggggtgg cggccggccg aagcatttgg
     8221 ccggcggcca gttcgcggta agtggggctg ctggtgagta gttcctcgtg acgcccgcag
     8281 gcgacggctc tgccctcgtc caacacgatg atccggtccg cgtgctggac cgtggagagc
     8341 cggtgtgcga tgaccagcag ggcgcattcc cgggcgacgt ccttcatcac ggtggtgagc
     8401 gcggtttcat tgagggtgtc gaggtgggag gtgggctcgt cgagcagaag gatcgagggg
     8461 cgggcgagca gggcgcgggc cagggccacg cgctggcgct ctcccgcgga cagcctgctg
     8521 ccgcgctcac cgagcattcc cgacaagccg cccggcagtc gccgtacgac cccttccagc
     8581 tgggcgagct cgacggcgcg tcgcacttcg gcctcggtgg cgtcgggcgc ggcgtaggtg
     8641 atgttgtccc acagggtgcc gtggacgacg tgggtgttct ggtcgacgac ggcgatgcgc
     8701 ccgcggcatg cggcgcggct cagttcggtg gcgggcaggc cgtcgaagag cagggtcccg
     8761 gagtccggtt cgtaaaatct ggagatgagg gcgaagatcg tgctctttcc ggcacccgac
     8821 aggccgacca gggctgtctg gcaccggtga ggggcggtga aggagaggcc gcgcagcacc
     8881 ggccggctcg ggtcgtagcc gaagccgatg tcccgcaggg cgagggcggg tttctcgtac
     8941 gagacggtct gccgggccgg ttcgcgtgta cgtgcccgga cggtcggcgt ctcctgggag
     9001 ggctccgccg gcagggacag cgcctgctcg atgcgctggt aggcccccat gccacgctgg
     9061 atcaggccga ccgcccggaa gaccgaggac agcggaagga ccaggtagga ggcgtacagc
     9121 aggaaggcga ccaggtcgcc gagggagttg gcgtggccgt tgacccgcag gccgccgatg
     9181 accaggacga tcaggaagga gccctgtacc gcgagttcga ccgccgggct catcacggag
     9241 gcaagtttcg cggtgcgtac gccggcgctg tacgccgatt cgacacattc tccgatgcgg
     9301 cccgcttcac ggtcctcggt tcggtgaacc cggaccatcg gcagggcgcc gagcgcgcgt
     9361 tcgaggtcgg cggcgatcgc gccgacggag gtctgcatgc gttcggaggc agcccggatt
     9421 cccttgagaa gcgaggcgac gatcgcggcg gcggtagcca cggtcgccgc gatcaggagc
     9481 agcagcagcg ggtcgatcca cgccatgagg acgatcgccc ccgccgcgac gagggcaccc
     9541 gtcaacagat cgaccagtgc ttgggagacg acttctctga gcagggtggt gtcggtggtg
     9601 acccgggaga tcaggtcgcc gctgcggagc cggtcgtact cccgcatctc cagccggagc
     9661 agccgcccca ccaggctgtg gcgcagccct cgtacgatgc cttcgcccat gcgctccaga
     9721 acgaagcggc ctacagcgcc ggtcgccgct tcggtgacga agagcccggc gaggagaagc
     9781 aacagtggcc acaacacctg tccgcgcccg ctcgcgtcca cgacctgctt ggcagcgagc
     9841 ggctgggcga gcccgagcgc ggagccgacg agggtgagta cggtggcgag ggtgagggac
     9901 gcccggtggc cggtggtgag ccggtacatg gtggcgatcg cggcccgggt ggagcggtcg
     9961 ccctcggccg ccgactgtgt ctgatccacg acggtgtcgg tcatcggcct gatcggctcg
    10021 cgacggcgac cgtgatgagc cgggtgaagt agtcgtcggg tacgccctcg tccacagggc
    10081 ggccgtccgc ctcgatccag gcgtgcgccg tgaacggcgg caccacgcgt accccggtgc
    10141 accaggtcgg ccagctccct cccaggcggc acagcagcgc ggctcccaga gaacggggca
    10201 ggcagccttt cgggcctgcg cagcgcaggc tcaccgcgca catcgcgtcc cgtgcgttct
    10261 ttgcctgggc ggcggtggcc ggcatggctc cgcgacatgc gaagtggagc acggcgcgga
    10321 gccggcgggg cggcaggagc gagagcgcga gggcggggga aaggacgaga cgggcggcca
    10381 tgcgccgggc gaagggcacg ccggtgggcc gctccagggc gctgggggtc gtcattcggc
    10441 cagccccgag gtccgcagtt gctgtacgag ggcgtcgacg tcctgcttcg cctggacgag
    10501 gtcgatgtcg aactcgtcgg cgagcgcgac gaccgcggcg gcttcgtcac cgcccgccat
    10561 cagggtgttg accaccaagg tgccggtggg attcaactcc caatattccc cggcgcgttc
    10621 gtccagcagg accgtgccgt agtccgtctc ggcagtggag acattggcgc cgaacttcaa
    10681 tgccatgcgg gtgtctttct gctggggaac ggtggtcatg aggaggcggg ggccttgggc
    10741 tcgctagttc ggtggaggcc gcgcagccac acttcggcgg cgatggtcga gtagaggatc
    10801 gcgtcgcgca gttcgggtgt ggccggacgc tgggcgagcc ggcgcagggc cgtgccgtcg
    10861 acgaggccga gctgttccag ccgggagccc tcccagagcg ccagcagatc ggcgcggtgt
    10921 tcgcgcagtc cgttggatgc gtccatggaa gcggcggcct tgttggtgcg ccgcaggcac
    10981 gcatcgggca cgatcccgct catggcggcg gtcaggaggg gtttgtactg ccagggcgtg
    11041 acgcgctcgc tcgggcggac ggcgaggcat gcctcgatga cgcggtcgtc gaggaacggc
    11101 gatgccatcg gaactccggc ccgggcggcc atccggtccc actggcggat gatgcgggtg
    11161 caggaaagga tctgttcgag gtcggtgtgc aggccgcggt ccgggtgcag cggtacggcg
    11221 gtcatggcgg cctcgcgcag cgcccgttgg gccatccgtt cggcgtcggc ggtgacccag
    11281 tcgaacaggc gagggggcat gccccagccg aggctggtgc tgacggtggc ggggagcggg
    11341 tctcgcaggc ggccgctgga gtcggccagc cacttcccgt acggccgcga gtcggccagc
    11401 gcgcgtgccg tgccgccaag tggccactgc cacagggccc tgaagccgcg cagttggcgc
    11461 agcgcgaaca gcgggcgggt gcggagcagc cggtggtagt acgcctccga gcaccaggcc
    11521 acgtggtcgc cgccgatgcc ggtcaggtgc aaccggctgc cccgctccgc caggccgggc
    11581 agatggtgca ggacccttga tcggtccatg acgccgatgg tcggctcgtc cagcaggtca
    11641 tcgatgtcga gcaggccggt gtagacgagc ggcgaggtat cggcgtccca gaccacatgg
    11701 tcgatttccg gcaacgagcg ggcggcctgt tcagcccagt acagatcggt gtcggcgggg
    11761 tcgcgacccg gccaggtgct ggccaccacc cgggccggtg agcggtccgc caggaaacag
    11821 atggaggtgg aatccaggcc gcccgacagg tcgcagctga ccacgccacc ctgccgggta
    11881 cgggcgtcga ccgccgccgc cagggcttcg cggacgagcg gggcgccatc ggcgagcgtg
    11941 cgtaccggtt ccggcggagt ccaccagcgc gagcggcgta cggtccggcc gtccggcgag
    12001 atgatcagcg cgtcctgggg ggacacggcg gtgatccctc gccacatggg tgcctcggcg
    12061 agtgtatggg gaaccggcca cagcagccgg atggccagtt gctcctcgtc cgggtcggtg
    12121 cccagcgcgg cggcgagtac gtcggcgcgg gtggcagcca cctgcgttcc gtcaacgggg
    12181 gcatggaata ccagccggag cccggaggcg gtgccctgca ccctgagccg cccatcgagc
    12241 gcggcgacga gatggaaact ccctggaagg gagcgggcca gtgcgtcgag ttcggcgaga
    12301 tcacgtagcc gcccggcttg gcgctcgagc tctacggcgt cgatcggaca gcagccgatg
    12361 acggcgaggg ccgtgtggcc ggcgcgcgcg gtgacgatct cctggtcgtg ccactgcccc
    12421 accagccagg gccggcccga agcgtgctgc aggattcgcg ttccggggcg ggcgaaggag
    12481 cgggccacgg cggtcgcgtc ctcccggtcg gtgaagaccg tgaagtgcgc gtcgccgggg
    12541 cccgtccccg cactttcgtg cagttcagtc atgacgtcgg gtcaggaacc gtcgctcgtc
    12601 agttcttgct caggatgaga cggtcgttgc cggagcgccc caagagcccg gtcttcttcc
    12661 ggaacgttcc gagccggacc agcgtcggag cctcgtaagc cttcttcatg acttctcctg
    12721 acgtacaggt gtcacgaccg cccctcctgg ccggcaggga accggaggcc gattcactgc
    12781 cgtcctgtcc aggctcatcg ggagccggaa caaggaagcg ggtgcacgca atagctacgt
    12841 gcatagcgga ttccgtcgca aggccgtcag agaaaatagg atcatatgtg aaattctaaa
    12901 gtagccagag agctttactg tggcccacga tgttcgtcaa aaatagaaca ttaggcgagc
    12961 ggggtgcgca caaggacaga aaatcgtttc gacctctgcg tcgagaagcg cacggtgggt
    13021 gtggcgaagg ggcgcacggc gggagccgga cggagccgcc ggggcgcact ccgataaggc
    13081 caccgtgctc cggtgccctc tgcggtgaag gcacgcctga caatgaggtt ttttcgatga
    13141 aatgattttc gctaaactga tcaaagtgac ttgaagcggg atgttccctg cggtggtcga
    13201 gtagggcgcc ctggctgctg acagccgcaa agcccctggt aggacggttc tccccacaag
    13261 atcgtccgtt gaaccagagg cttcacgttg gtcacctgtg ttgccatgcc cgacgtcccg
    13321 tgccgcatag tgaaaggggg cagatcccat gagggtgctg tcgatcaggc agtggttatg
    13381 gcctggtcgc ggtagcgcgt ctggtggttg tggatggatt cctgctgctg gtgccacgcc
    13441 caggaggcga cgaagtcgcc gttggcgcgg acggcacgca gtttgagcac ggtttcagct
    13501 ccggacaggc cccagcgggc gccggtgatg tccaggcggt ctttgaccag gtgtcggcat
    13561 gctccctcga tgattccggt ggagatcggc cagccgcgtt caagggcggt gtcgtagcgc
    13621 aggtgctcgg ccttgccgga caggtagttc atggcctcgt cgatgctctt gcgctgggtg
    13681 ccacgctgtc cggcggcgtg ggcggctttc tcgagtgcgg cggtggaaat gctgtcatgc
    13741 aggcaccagg ctgctcgcca caggtattcg agcacgtgga tcaggtcgac gatgatgtgg
    13801 acgtccacgc tgcgctgtag tgcttcggcc ttgaggaggt cgatctgatg gcgggccccg
    13861 tcgaccagga cgtcccagca acgacggtgg ccggtgtcgc ggtgctctgc ctggtcgaac
    13921 acggcggcca ccacctgcgc ggcggtgtcg gtcaccgagc cgcacaacca cttcgaccgg
    13981 gccttcggcc cctggcggcg ctcgggcgcc gcgccgcgga cggcgtcgtc ttgccgtcgt
    14041 cgactgtgcg cggagcgggt tcggcatcgt agacggctcc cagggtggcc atccgtttcc
    14101 tgccgtgttt ctccccggag gccagccggg tcttcatcgc gttgccaccc ttggcggccg
    14161 cagccctggc ggtgtcctcg cgcagggctt cgggcctcat catcatgccc ttgccgtcga
    14221 ccgacaagat cagtggcgtg gtgtcggtgc agggagcggg caccagggcg tcgtagaacg
    14281 cgtcgatgtc cgccgcggca ctgacagcga gttcctggac ctgccggagc cggtaacggc
    14341 gttgatccgc tcgcaggcgt cggcgtagct tccgcgggcg gactcgatcg cggcgagcct
    14401 ggccagcccg tgcgagtgca ttgcgtccgg aaggttcagc accgcgtcgg ccgggtgcag
    14461 gtccgccacg ccggtgccgc ggtaggcgat ccggaccggc actgtccact ctcgcggtgg
    14521 agcaccatcg cattgggaag ggagtccgcc gccttgtgcc tccccagccg gcgcagtctc
    14581 cacggtgcga gaggcagtgc accgcctcag ggggctgctc ttgggtggtg acctcaatgt
    14641 tggcaatgta tcttgatgac atacatcgtg gatgctggag gtgctcgatg tccgtcacac
    14701 agattgatct cgatgacgag gcgctcgctg aggctatgcg gctgatgggc gtcacgacga
    14761 agaaggagac ggtcaacgcg gccctgcggg actatgtggc ccggatcaag cgcctcgacg
    14821 ccgccgagaa actggccgcg cgcggtgcac gtggcgagtt cgagcaggct gcggcggcgt
    14881 attacgcagg caagcgtgcc cgacgcgagg ccttcgagtg atcacatacc tgctcgacac
    14941 ctccgccctg tggcacctgt tccgcactcc cggagctctg gcaccctggg aggggcacat
    15001 cgccgccggg gtgttccacc tctgcgagcc gacacgtgcc gaatttctct actcggcaac
    15061 cagtccgact caccgggacg agctcgcgga ggagctggac gcactctgcc tgctctctcc
    15121 cgttccgaag aatgcctggc gttgggtcga taccgcccag tacaagttga cacaacaggg
    15181 tcagcatcgt gcggcaggag cgatcgacct gttggtgtgt gcgaccgcgg tccaccacgg
    15241 gcacaccgtc ctccatgtgg acaacgactt cgcgacggtc gccggagtgc tcaaggaact
    15301 tcagcagcga gacgtgcgag cctgatcact agggccgcct ccatattgtt ggtctgttgg
    15361 cccttttcgt ggtcgaagcc caagtcattg ttccaggggt caccgcgtca ccgtccccac
    15421 cgatcgcagg ctgggccctg cggacccact gccgcagagc ccagtgctgg ccccgaggtc
    15481 catggtgacg agccgatcga acggccgctg gacagcgccg gctgaaccgc atcccgcgcg
    15541 tccgccgagt tggagcgacg tccgggtgta ttgggcgggc attcaaggag cgtcaggggc
    15601 cattgagggg ccacaaggac aggaacgcat cgccaagcac cacacaggac tgacactgat
    15661 cagcgcgtct gacctgggaa gacatcaagg atgagcatgg atcgacaagg gtcgccgaga
    15721 tccccaaagg actcataaac cgtcggccgt gggttcgagt cccacccgcc ccacctgtgc
    15781 aggtctctgg cctgcggaaa cgttccttgc gaggtgctgg agcgtcaact ttcgtccaac
    15841 ggacggaatc cgctcctcgc gagtttgacg ccagggcggt ctgcatcggc ggatacctgc
    15901 ctgacctgca tggacgcgtc ggatgggtag ctggtgcggg ctgcggcagg tgagcacccg
    15961 gccctctcgt gcggtgcccc gtggctcggt tggcagagcg gagggggtcg gcggcctcga
    16021 cggatcgccc tcgcggcggc ggtgctgacg ggcgacgtac atgtccgatc tgaagacggc
    16081 ccggccgcat cggcgaatac gtcgaatacg tcgaatacgt cgaatacgtc gaatacgtcg
    16141 aatacgtcga tgatgtcggg gacatcaatg tcgacggtgc gcaggccacc gccactcgtg
    16201 ggcgggccga ccggccggcc gatgggatgt ggcagggcca tcgtccacga acgcgcgcag
    16261 atcgtcgacg atcccatcat gtgacgagga gttgaccatc cagtcgttca tacgctgatg
    16321 ccgtgacgga acagctggtg gtggacggtc ccggagcggg ctggacctcg gtggtcaccg
    16381 ggcatctgcg gtggatcgag gggctgctcg acagcctcgg tctaccggcc gaacgctccg
    16441 acgagctgcg ggcccggctt ctcgcggttc aggcgcgggc agccgacccg cagttgcggg
    16501 tggcggtctt cggtgagacg tccagcggca agagcacgct gctcaacgcc ttcctgcgac
    16561 gccggttgct gccgtcctcc gccctcgtga cgacacgtac gaccacggtg ctggaatacc
    16621 gcgagggcgc cgagggcctg atggtgagta ccacggacga ctccgtcctg gagtggccgt
    16681 ccgcgccgtt cgccgggtgg gcggggcggg ggcgggagtc cgggcctgac accttggagc
    16741 gggcactgcg gcgggtgctg accacagcac tggcggacga ggtgggcagt ctgcgggtgc
    16801 tctcgccggt ccggctgctg ggccccggcg tcacggtgat cgacaccccg gggttcagcg
    16861 tgacggaacg tggacaccgg gagctcgccg aggccgcggc gcggcaggcg gacgtggcgc
    16921 tggtggtggt gcccgccgtc gcggcgatgt cgctgaccct ggtggacttt ctcaccgggc
    16981 cgctgcgcga ccatcacgac cggtgcgcgt tcgtcctcac caagctcgac ctgctcgacg
    17041 aagatgaacg ctccgaagcc gtcgaggtgg tcgagcgtcg gctgagggat ctgggatgcg
    17101 cggatccgct gctgctgccc tgctccccgg gcaaggcgct gggcgaggtc accgctgtcg
    17161 gcgtccgcga gccgggtggg tccggccatc tcgcgtcgtt cctcgaggtg gaggcgcgga
    17221 tcgcacggct cgcggcggac agccgccggt cggccgtcgc cgccacggtg ctcgggttgc
    17281 tctcggagct gctgtcggcg gtggaggaga ccgccgaggc ccggcgcgcc gccctcagcc
    17341 gtggcgagcg cgaactggcg gccctgacgc tgccggacct ccccgccttc ctcgacgcct
    17401 gggccgcgcg cacccgggac cgggccagga cggagctgaa cgccgccacc ctgacccgga
    17461 cttcggcgca gtcccgtacg acgctcgagg tgaaagtcgg caacacggtg gcgggcgaga
    17521 agatcaacga cctggccggt gccgcggagg aggtgtcccg gctggtccgg cgccacttac
    17581 ggcgggacgc ccagcaagcc gtccgcacgg cggtgaaacg ggccggcgag gtgctgaccg
    17641 ccgctgccga ggaactcgcc cgggacttcg cggcccagta cagcgtgctg accgacctgg
    17701 ccggcgaggc ccggacggct cccccggtgc cccaggtggt gtggccggag cccccggccc
    17761 cggacatgtc cggcatcgac cgggcgctca ccgcgatcgg cacccagctg accagcagtg
    17821 gcaactggcg caccggcggc ggcgcgatgg ccggtgccct ggccggcagc ctggtcgccc
    17881 cgggcatcgg caccgtcatc ggcggcgcgc tcggcgcgct catcgggcgc cgcggccccg
    17941 acgcgacccg ggagcagttc ctgcggcagg cccgtcccgt catcgccgcc gcgcacgatg
    18001 agatcggcgc cctcgccgcc gcctgcctgc cgcgcgtcgc ggagggcctc agcgacagcg
    18061 tcgccgcgct ccgccggcag tacgacgagg agtggcgcga cgagatcgcc cgcctcaccg
    18121 cggcccacga ccggcggcgg gccgaactgg ccgccgggat cgcccacgcc gagaagaccg
    18181 cgacggatgc ccggcgacgc cgcgacgcag tcgcctccct gcgccgggag accagccgga
    18241 ccgtccccga cctcaaggag tcatgacccg tgagcagcgc atcccgatcc gaggcaggcc
    18301 ccccgccggc ggccgacccc tccgcccacg tcggcgacgt cggcgctacc gcctccggct
    18361 cgctgcggga ggcccgcagg ctcgccgagg actacggaca ggaccacatc cgggaggccc
    18421 tggacctgct ggccgccgga cgcggccgac ccgcgttccg catcgcggtg gtgggcgagt
    18481 tcaaccgcgg caagtccacg ctgatcaacc ggctcctggg ccgtgatctg ctgccgacgg
    18541 gatcccttcc ggtcacgcgg gcgccggtgg tgatccgggt ctccgacgcg gaggggctga
    18601 ccctcggccg gccggacggc cgccgtgaac tgcgcaagct cgacgacgac accctctggg
    18661 acgggctgac cggccccccg gcggaacggg aaccgggtgc tcccgccggg cccccggaac
    18721 ccaccgtgac cttggcggtg gccgatgact ggctcgccgg tctggacgcc gaagtggtgg
    18781 acacgccggg ggtcaactcc ggtacggagg agcagttcga gcaggtacgc cggaccgcgg
    18841 ccggaagcga cgccgtgctg ttcgtcgtct cggccctttc cccgatgagc atcacggagc
    18901 ggcgcctcct ggaggaggag gtcctgtgtc ggcacgtacc cttcgtcgcc gtcgtcgtga
    18961 ccatgctgga cctggtggac ggcgacgacc gcgaggagtc cgtacgggac ctcaaaaatc
    19021 ggctgtccgg cctggccggc ctgcccgtgc tgatcgcccc cgtgcccggc ggcggagagt
    19081 ccgaactcgc cgccctgcgc gtgctgttgg aggggttcgc gcgggacagt gaacgggcgc
    19141 tgtggcgcga ccgggggatc gccgcccaag tggcggacca ctgcgaggcc atggcccgga
    19201 tcgccgccga ggccgacgcg gtcggccggc tgccggaaga ggaggtggcg gaacgggcca
    19261 ggctggcgca ggcgctgcgg gagagcgaag accggcagtg ggagcagctc cggacagaca
    19321 tgacgggacg tcagctccat ctgggcgccc ggctgcgtga acatgtccag aaggggcgcg
    19381 acggcatcat cgaacggctg cgctgggacc tggagcgcgc ctccgaaccg ggaacctggt
    19441 gggaacgcga cctgccggtc cggctggggc acgaactgtc gctgctggcc cggagctccg
    19501 agcgcacggt cctgctgccg gccatggccg cggacaccga ctggctggac agggaagtgg
    19561 cgcgcaggct gccgggcgcg gcacgcagcc cgctgcccgc cacgctggag ctgtccaccg
    19621 atccggacat ctccggcgag gtctccagcc tgtccaggac ccgcctggtc acccggctgg
    19681 gcgcccaggg cggttcgatc ctcggttttc tgatcgctgc cacccgccag ggcccgcgat
    19741 cggactccga ccggtccggc ccgccgccga tggtctacag cagcgtcctc agcctggtcg
    19801 gcgggctgct ggccgaggcg tacgtcagga acgccaccga ggagcagcgc cgccaggtcg
    19861 acgccgtcct ggtgcgggcg gtcgacgaga gcgcgggggt cttccagcgg cgggccgtcg
    19921 acgcgctcgg cgatgtctac gcggacatgt tcgcccggct ccgcgagtcc caccaggcct
    19981 gggcggacgc ccgacgggcg gcggtcgaat cgacatcggc atccggtacg gactggccga
    20041 gcctggcgag cgcggcggcg gagctggccg ccggcatccg ctccgcactc gccgacggcg
    20101 tacgggccga ggaggaacag gaatgaacca aggagaggac ggcctgccca tgacgaccgt
    20161 agaaggcggg tacgctgccg ccgccgaaca gcggctgcgg ctggccgaga tgtgccgccg
    20221 gacggagaag gccgccgaac agatcggcaa caacggcgcc gtccgggatg tgacggcgtt
    20281 gctcgaacgg atcgagaacg aggccttcca cgtgatggtg gtcggcgact tcaaccgtgg
    20341 gaaatccacc ttcgtcaacg ccctcctggg agaccgggtg ctgccggtca aggcggttcc
    20401 cgccaccgcc gttatcaccg aggtcaggtt cggcgagtcg ccggccgcgc tgctgtggac
    20461 agcggacgcg gccgagcccg aggccgtcga cccggaccgg ctcatcgaac tcatcacggt
    20521 gaacaacgcg tcggccgacg agcgcagccc gtacgtcaag gccgaggtgg tctggccgct
    20581 ggagctgtgc cgccacaacg tcgtactgat cgactcgccc ggcctcaacg cgtacgagac
    20641 ccatgacgac atcaccctca cgcatctcag caaggccgac gcggtgatct tcctgcagca
    20701 cgcgatcgcc ccgatgagca tcagcgagtc cacgttcctg aagaagtacc tgagcgcgca
    20761 cgacccgttc ttcgtgttca cctacttcga cgccatcgac gatcacgagc gcgacgacgt
    20821 cacggcctcc gcccggcgac gcgtcaccga tctgcggggc gaggaccggg accggagccg
    20881 gttcttcttc gtcgacggca agtcggcgct gcgcgcccgg atggctgagg acgacgaggc
    20941 gttccgccgc accggcgtgg aggcggtgga gagggaactg gaacggtacc tcgtgaccga
    21001 gcggcacaag gtcaagctgc tcgccccggc ccgctccgtg cgcggcgtcg cacgggaact
    21061 gcgccgcaac atcccctccg agctccagat gctcgaagcg gagagcggtg acctggaacg
    21121 gaactgggcc gccgcccagc agcccctcag ggaactggag gcgcaggccc agcagatcac
    21181 cctggacatc cgcaacgaga cccgggtgct gcaggaccgg gtggagaccc tgctcggggg
    21241 cttcctcgcg gccgtcgccg acgaggcgcc gctggtcgca caggacgtgg agatcaccac
    21301 caagctcggc ctgaacctcc tgaaagccaa agtgcgtgcc cagcaggtgg cggaggagat
    21361 cgccggcggc acggcgaagg ccatggagga gaaggtcgcc ctctgggtgg gcgagtcgct
    21421 gaaacccgtg atcgagcagg acctggaacg gctcgccgag cggatgaacg ccgaactgac
    21481 ctctttcgag gcggccctgg agaaactccg gatcgacctg cacggggcgt ccggggcggc
    21541 cgacgcggga gagggccggg aggacgagcc gctgaccaag ttcctggcgg gcttgggcgg
    21601 gttcgtgctc agcgggccgg cgggcgccct ggtcggagcg cggttcgggg cgaaggaggc
    21661 gctgcgtacc ttcctgcccg ccttcgccat cggcgcggcc tgggcgctca ccccgttcgg
    21721 gctgcccgtg ctggtggcgg ccctgatcgg tcagggcttg ttccaaggca agggcgccgg
    21781 tgagcgcgtg gagaagaaga tgcgggagga gatcggccgc gcgatggcca cccagttgcg
    21841 gttggccgca ccgaaggagg cccagaaggc cgcccgggcc ttcgccgcgg acaccatgga
    21901 gcccatgcag cgggagatca cgcagggcat gtccttccgg atcgaggaac tcacccgcag
    21961 tgtggcctcc gcccgccagg tcctggacca gggcgaggag gcggtcgagc ggcgccgcgg
    22021 cgaactgaac cggctggacg ggctcctggg ccgcgccgac gacgagatcg gtgacctggt
    22081 cgccgagttg acgaggatgt gatggcccgt taccgcaggc ggctgtgcct ggccgtggac
    22141 ctgcgccagt acagccgtca cggctaccgc gcgcaggagg acgcgcagta ccggctccgg
    22201 ctcgtggtcg agcacgcgct gcgccgggcc cgggtgctgc gcgtccgtgc ccagcagcag
    22261 gtgcaggggg acggccagtt ggtcgtcttc ccggccggga tcgacgccgt acgtgtggtc
    22321 ccggcgctga tcctcggcct gcgtgacggc ctctaccagg cgaaccgcac gcccggtgcc
    22381 ttcggccgga tgcggatgcg ggccgctctc gcgctggggt cggtctcccg ggccgaccgc
    22441 ggttacctgg gcgactccgt ggtgctggtc aaccggctcg tcgacgcgga cggactgcgc
    22501 gacgccctcg aaaacgaaga cggcagcgac ttggcgctgg ccgtgccgga cgagatgtac
    22561 cgggacgtga tc
//
