LOCUS       NC_003155              13461 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6787151
            Orig. end                         :: 6800612
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..13461
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aminopolycarboxylic-acid"
                     /region_number="30"
                     /rules="(AesA and AesB and AesC)"
                     /tool="antismash"
     cand_cluster    1..13461
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(AesA and AesB and AesC)"
                     /kind="single"
                     /product="aminopolycarboxylic-acid"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13461
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8461](-)"
                     /cutoff="10000"
                     /detection_rule="(AesA and AesB and AesC)"
                     /neighbourhood="5000"
                     /product="aminopolycarboxylic-acid"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..8461)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(AesA and AesB and AesC)"
                     /neighbourhood="5000"
                     /product="aminopolycarboxylic-acid"
                     /protocluster_number="1"
     misc_feature    48..63
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.92"
                     /tool="antismash"
     gene            complement(477..2108)
                     /db_xref="GeneID:41542700"
                     /locus_tag="SAVERM_RS28955"
                     /old_locus_tag="SAV_5611"
                     /old_locus_tag="SAVERM_5611"
     CDS             complement(477..2108)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542700"
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042121.1"
                     /locus_tag="SAVERM_RS28955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5611"
                     /old_locus_tag="SAVERM_5611"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_010987013.1"
                     /transl_table=11
                     /translation="MRDATHDVPALHRRSFLKYSGALGAAAALSSSLAACSSGPESTND
                     TGGGGSGGNRTLTAVIGYGNDGSWDPTQTASAFSMAANNHIYEGLLDTDPISREPYAAL
                     ATQVPKDLGGTSWKFTLRSGATFHDGKPVTADDVVFVFGRILDPKTQTLVKGFFASWLK
                     DVRKIDAQNVELVLKFPFPEGVSRLTLAKIMPRHVFSRPGAWEDAIKGKAVGSGPYRQT
                     AHHPKSNTTFEAFAGYNGPRKPAFKKMNWLTIVDAAPRVAKVSGASAGAQLADNIPYAN
                     IQQLKKDGMTVEGGAGMNNLFLMFNTKHKPFDDVRVRQALHYAIDTGKMVEVALKGHGK
                     PSSSFLNEGNPAYRKAKTVYDYDPEKAKELLKAAGVKGLEIEILSVNVSWIVDCLPTIK
                     ASWDAIGVRTTLSPQETTAVFTKMDQKQDYQVVAAASNPNQFGLDADLIMHYNYGPQNL
                     WMQYARWAGDSVAKQLFRDMDLATRQPDAEKKKLMIQDYIDVVAEQAVLYPVVHNELMT
                     AWDPEKLSGIRAQPYPGVNLLQAKWA"
     misc_feature    2240..2256
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.23"
                     /tool="antismash"
     gene            2340..3044
                     /db_xref="GeneID:41542701"
                     /locus_tag="SAVERM_RS28960"
                     /old_locus_tag="SAV_5612"
                     /old_locus_tag="SAVERM_5612"
     CDS             2340..3044
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542701"
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042123.1"
                     /locus_tag="SAVERM_RS28960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5612"
                     /old_locus_tag="SAVERM_5612"
                     /product="FadR/GntR family transcriptional regulator"
                     /protein_id="WP_107082953.1"
                     /transl_table=11
                     /translation="MSEETGNSRIRREVVQLILDRRLRAGAPLPTETELMEDLGVSRNS
                     VREALKALQALDIVEIRHGYGTYVGRASLTPLVDGLTFRTLSRPDDDTDALAEILQVRE
                     VLEEGLIRRVTATLSEAELDRLESVVARMETAGRAGRSFAELDREFHELLYASLGNAFV
                     PQLLGAFWTVFRRVAGARDWTDDPAPAVTARRHRDILTALRARDVEGAQRAMADHFRGI
                     EARAAEESRGVG"
     gene            3070..3504
                     /db_xref="GeneID:41542702"
                     /locus_tag="SAVERM_RS28965"
                     /old_locus_tag="SAV_5613"
                     /old_locus_tag="SAVERM_5613"
     CDS             3070..3504
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990114.1"
                     /locus_tag="SAVERM_RS28965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5613"
                     /old_locus_tag="SAVERM_5613"
                     /product="protein-tyrosine phosphatase family protein"
                     /protein_id="WP_010987015.1"
                     /transl_table=11
                     /translation="MTDTWSPTDVGVLRLPSGRLVRGRGLRRPLPEGQEPTYAVYLLGK
                     RPPEVPWEAHWLRWPDFRLPSSRTQAREVLTDAWRRAAAERVEIACGGGRGRTGTALAC
                     LAVLDGVPPQEAVAYVRAHYDRHAVETPWQRRYVRQAGCW"
     gene            complement(3556..4995)
                     /db_xref="GeneID:41542703"
                     /locus_tag="SAVERM_RS28970"
                     /old_locus_tag="SAV_5614"
                     /old_locus_tag="SAVERM_5614"
     CDS             complement(3556..4995)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542703"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138039.1"
                     /locus_tag="SAVERM_RS28970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5614"
                     /old_locus_tag="SAVERM_5614"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_010987016.1"
                     /transl_table=11
                     /translation="MLTTLLRDSRALAALAVPLILTQLAQVALTTTDTVMMGLLGTREL
                     AAGGLALVIFNQLRTMGVGLVTSVGNQIAAAGARAEQAEQAEAERTAGRDDDGRGHAQE
                     EAHEEMRGIVRASLALATLAGLAGAVLMILIGQALPWLGQDAAVADRAQTMLFALAPGL
                     LPCLWFQAIRQFTVGMRRPQALLRITVASVAVNAGLNWVLIHGTWGLPRMGLTGVGVAT
                     SSVYVLTCIALYVSARKDGALAPLLALDVMKADPAVLRRLLRLGLPIAATYGSEAGFFS
                     LTALMAGSFGPAALAAHTAVNQLVYIVFQVAVGLSHAASINVSRELAVGRYEDAGRIKN
                     TALACAAAVMTVVGVVYLTLPELVLAPFLESGSGQALTIATHLLVVTAFLQFFDCAQNI
                     GVGLLRGLDDTRSGFRITLIGYWAVGLPAAWLLAYALELDTLGIWLGLLTGLATTAVLL
                     LRRYAQSLTTRSARHTPLTAT"
     misc_feature    complement(4989..5003)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.42"
                     /tool="antismash"
     gene            complement(5001..6029)
                     /db_xref="GeneID:41542704"
                     /locus_tag="SAVERM_RS28975"
                     /old_locus_tag="SAV_5615"
                     /old_locus_tag="SAVERM_5615"
     CDS             complement(5001..6029)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542704"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546198.1"
                     /locus_tag="SAVERM_RS28975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5615"
                     /old_locus_tag="SAVERM_5615"
                     /product="cysteine synthase family protein"
                     /protein_id="WP_010987017.1"
                     /sec_met_domain="AesC (E-value: 2.9e-174, bitscore: 577.8,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PALP (E-value: 1.6e-54, bitscore: 184.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGSLRRPSVVSRVSDLIGYTPLLELAATETGSRLLLKLEMFNPT
                     GTAKIRMARQMITDAEERGELRAGGRIIESTSGNTGLGLAVIAAERGYTFTAVVDNHAA
                     VDKLRAMKALGAELVHVVDDGTDELATAAREELAEEMARGQDNTIFTEQHNNPSNGVGY
                     FPVAHELHEALDGRLDVLVGAVGTGGGLCGTARELRTLIPGFTTIGVEPKGSIAFGGPA
                     HDYYQSGTGTPEGAPIGALVDFGLIDEGAKVGDVEAFATCRAVARTGLLIGGSAGGVVH
                     EALTRLPGLPPGTTMVALINDGGEKYMDTVFNDDWMRARDLLDPAAEREVDELLTKLRG
                     NR"
     gene            complement(6072..7439)
                     /db_xref="GeneID:41542705"
                     /locus_tag="SAVERM_RS28980"
                     /old_locus_tag="SAV_5616"
                     /old_locus_tag="SAVERM_5616"
     CDS             complement(6072..7439)
                     /codon_start=1
                     /db_xref="GeneID:41542705"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955048.1"
                     /locus_tag="SAVERM_RS28980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5616"
                     /old_locus_tag="SAVERM_5616"
                     /product="Y4yA family PLP-dependent enzyme"
                     /protein_id="WP_306292878.1"
                     /sec_met_domain="AesB (E-value: 4.9e-186, bitscore: 617.0,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 4.7e-17, bitscore:
                     61.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPPALPTLPALPDPAADAVLGSGLLEELAYALGGPFHFLLPDA
                     FDANLRALHSVLDETGVDGFVYFAKKANKAAVWAERSAAGGAGVDVASAAELRQALGHG
                     VRGEHLVVTGPAKDLALLGLAVRHGALIAVDALDELDTLITTVSGDRTRPARLLLRCLP
                     PAQPHSRFGLGEAEVALALERCVTAGEAVRMEGFSFHLSGYDVKLRADLAGHLVELCLK
                     ARVLGLEADRISIGGGLPVSYSSAADWNTFLTRQNGGHYHADRTFDPDGFYPYHSPVAG
                     ADALRRILATRPEGHRPSLAALLNDAGITLLLEPGRALLDRAGGTVFRVQGVKDRDGYQ
                     LLTVNGTSLSLSEQWFNSEYLPDPHLLSAHPDTPDAVWPAAVGAATCLESDMLTWRKVP
                     FPRRPRTGDLLVYPNTAGYQMDSNESPFHDLALPPKVVIDHTDRARPRWRLDRHAP"
     gene            complement(7436..8461)
                     /db_xref="GeneID:41542706"
                     /locus_tag="SAVERM_RS28985"
                     /old_locus_tag="SAV_5617"
                     /old_locus_tag="SAVERM_5617"
     CDS             complement(7436..8461)
                     /codon_start=1
                     /db_xref="GeneID:41542706"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091640.1"
                     /locus_tag="SAVERM_RS28985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5617"
                     /old_locus_tag="SAVERM_5617"
                     /product="ornithine cyclodeaminase"
                     /protein_id="WP_107082960.1"
                     /sec_met_domain="AesA (E-value: 1e-161, bitscore: 535.8,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDASTTAAAEPIPRADRHLRILSTGDLAGIDISLADVVSTVEDA
                     YRTLHAGESDNPRKLTVKPRDGHSVAYAMLGRDGSRDVVAVKTSYKHGLDKGREEQHYY
                     TTLTLYDDVTGLPVAMMDCSRIGSLRTPAVSALLARECAAPGARSALVIGTGTQGRLAL
                     PFLLTTLPGLDRLMLFGTHPEGVTAVRERLRAHFPDRDVEIVTDAGAAASEADIIVATA
                     GGHTPAAVGADRLKPGSLSILVGHGLAPSALHRADRVIATSEAQMKVTGIDMADADGEL
                     RAVDAEFPPVITGDTAGRRTATERIFAYNSGLVVTDIALGHRFAQLALEQGLGTEVALW
                     R"
     gene            complement(8490..9482)
                     /db_xref="GeneID:41542707"
                     /locus_tag="SAVERM_RS28990"
                     /old_locus_tag="SAV_5618"
                     /old_locus_tag="SAVERM_5618"
     CDS             complement(8490..9482)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955050.1"
                     /locus_tag="SAVERM_RS28990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5618"
                     /old_locus_tag="SAVERM_5618"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_010987020.1"
                     /transl_table=11
                     /translation="MSTAAAPARQLDPDSVSELRQATEHIHAEFGTSATTPALLKRIAT
                     TANAFGDGLRHHCRPVDTDDGLFVLRGLDIDDAAAGPTPDSWATAGDSGAAHDITLLLL
                     ATVMGNPIAWEGQQDGRFVHNIVPSPGHETEQTGASSTVLLSPHTEDAFHPGRAHLLML
                     GCMRNHDDIATTAASVRKTRLSERDVRTLTRPVLPILPDDAYAEAQGYAEEPPPVPALF
                     ASEDGITLRFDPAYTPLDQADDAYRSAYGRLGEELARVSVAVSLAPGEVLVVDNDLVVH
                     GRVPFQARYDGTDRWLKRASVRVPGRRTRPLTEAHEHGYGQSAIEAHAR"
     misc_feature    9637..9655
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 30.9"
                     /tool="antismash"
     misc_feature    complement(9781..9796)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    9795..9813
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.57"
                     /tool="antismash"
     gene            9853..11403
                     /db_xref="GeneID:41542708"
                     /locus_tag="SAVERM_RS28995"
                     /old_locus_tag="SAV_5619"
                     /old_locus_tag="SAVERM_5619"
     CDS             9853..11403
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542708"
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548825.1"
                     /locus_tag="SAVERM_RS28995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5619"
                     /old_locus_tag="SAVERM_5619"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_010987021.1"
                     /transl_table=11
                     /translation="MNINRRQVLLAGGAMGASALLAACSGGGDDTSAASSDKGGKPRKG
                     GTLRIGALGRAGAITRDPHGTQGNESDYLILALVYDTLTVPGADPNTKPRLAASWEPSK
                     DLKTWRFKLAEDAAFHDGSPVTADDVVWSLRRLRNTPSGAARLPGIKAENITADGKDTV
                     VLVSDYANAELPPLTRLTTFVLKKGTSDKELAKAPGTGPFKLDRYRAGNARLVRNDQWY
                     GGTVYLDAIEVTMFETPQAMANALLAGQIDVASNAGAVAARTAKSRKDVQVVRRPDDMS
                     MPLVMRTADGPFADARVREAMRLVVDREAMVKQVLSGYGTVANDIMGTGDPGYAKDVPQ
                     RERDLAEAERLLSEAKFDLSKTYELVTTEDISGLAESATLFASQAREAGIKIKVVKQES
                     GAFYEKTWLKGDLYTTYWGTNDSVVFFASKTLVSEAGQNEAGFADKKFDATYRKVIATA
                     DPKARAEVLKELQRIEYDRSGYLLWGMADGIDLAASKVRGLPELAGYGRVQLENVWLG"
     gene            11517..12407
                     /db_xref="GeneID:41542709"
                     /locus_tag="SAVERM_RS29000"
                     /old_locus_tag="SAV_5620"
                     /old_locus_tag="SAVERM_5620"
     CDS             11517..12407
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542709"
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548824.1"
                     /locus_tag="SAVERM_RS29000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5620"
                     /old_locus_tag="SAVERM_5620"
                     /product="ABC transporter permease"
                     /protein_id="WP_010987022.1"
                     /transl_table=11
                     /translation="MLAILIAAVFAAVELLPGDAANATSERGDSAADVAARRHLLGLDR
                     PLWERFADWMTGLPTGDLGTSARGQKVTDLLADPFPNTLLLATVAFVLTAALSLALGCW
                     TAARPGSMTDRIVGHAATSAFAIPEFVVSVGLLIVLSLWTGWLPAVTLTGADGAPATWT
                     MLIMPALALVIPQTGWNTTIVRGALADQAATPHVEAAQLDGLSPHRVIWRHALPGAVPA
                     VATGLATSTGMLLGGAVVVETLFNYPGIGSVLAGAVANRDTPLIAGVVVCAGAAISLVL
                     LAADVIRARVLGASS"
     gene            12404..13252
                     /db_xref="GeneID:51982617"
                     /locus_tag="SAVERM_RS43425"
                     /old_locus_tag="SAV_5621"
                     /old_locus_tag="SAVERM_5621"
     CDS             12404..13252
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:51982617"
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091644.1"
                     /locus_tag="SAVERM_RS43425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5621"
                     /old_locus_tag="SAVERM_5621"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_010987023.1"
                     /transl_table=11
                     /translation="MSVATTGRRPATADGRGRVLPRVTPAILLVLLALTGPYLAAHPLD
                     KPVTAPFAPPGDGAPLGGDQLGRDVLSRLLHGGTALIGSALLVAFVVTLLAALIGCFAV
                     LHPVVGRAVERTADVFILLPPVLGIMLIALAWPGGGRWAVISAATVLGIPYAVRVVAGA
                     AAPLATAGYVEAALARGESVTYTATRELLPNLRGTVLALFGLRFVEAVYVISMAGFLQI
                     GPQPPAADWALMIRENAPGILLNPWAVVAPSLTIALLAISVNLAATSLAPRSARKAVTT
                     P"
ORIGIN
        1 gcgccagcca gaagccgggg gcggcgacgc cggtgagcga gaccacccgg accagctggt
       61 cgggcagccg gtcgcggtag atggcggcgg tcactccgcc ggtcagggcg agcaccaccg
      121 cgatgccgag gcccaggaag gtgagctgga gcgtgagcgg cagcgcggtg gtgacctgct
      181 cgaccaccgg cgcccgggtc agcgcgctga tgcccaggtc gccgtgcagc aggtcgccca
      241 cgaagtggac gtagcgcacc ggcagcgggt cgagcaggcc gttctgctgc cggaagtcgt
      301 gcagttgccg cggtgtgggg ttcgcgccct ggaagaacgc ggacgccggg tcgacgtccg
      361 agaaccgcat caccaggaac acgaagagca cgatgccgag catcagcggg acgagcagga
      421 cgacacggcg ggccaggatt ctggcgatgg cgatcactgc ggcgactccc ctgtacttac
      481 gcccacttgg cctggaggag attgacgccg gggtagggct gggccctgat cccgctgagc
      541 ttctccgggt cccaggcggt catcagctcg ttgtggacga ccgggtagag cacggcctgt
      601 tcggcgacga cgtcgatgta gtcctggatc atcaacttct tcttctcggc gtccggctgc
      661 cgggtggcca ggtccatgtc cctgaagagc tgcttggcga cggagtcgcc ggcccagcgg
      721 gcgtactgca tccacaggtt ctgggggccg tagttgtagt gcatgatcag gtcggcgtcg
      781 aggccgaact ggttggggtt cgaggcggcg gcgacgacct ggtagtcctg cttctggtcc
      841 atcttcgtga agacggccgt ggtctcctgc ggggagagcg tggtccgcac gccgatcgcg
      901 tcccaggacg ccttgatggt cggcagacag tccacgatcc agctgacgtt caccgagagg
      961 atctcgatct ccagtccctt gacgccggcc gccttcagaa gctccttggc cttctcgggg
     1021 tcgtagtcgt agacggtctt cgccttgcgg taagccgggt tgccctcgtt gaggaacgaa
     1081 ctcgagggct tgccatggcc tttgagggcg acctcgacca tcttgccggt gtcgatggcg
     1141 tagtggaggg cctggcgcac gcgcacgtcg tcgaacggct tgtgtttggt gttgaacatc
     1201 aggaacaggt tgttcatccc tgccccgccc tcgacggtca tcccgtcctt cttcagctgc
     1261 tggatgttgg cgtacgggat gttgtcggcg agctgcgcgc cggcgctcgc gccggagacc
     1321 ttcgcgacgc gcggggcggc gtcgacgatg gtcagccagt tcatcttctt gaaggccggc
     1381 ttgcgcgggc cgttgtagcc ggcgaacgcc tcgaacgtgg tgttggactt cgggtggtgc
     1441 gcggtctgcc ggtacggccc cgagcccacc gccttgccct tgatcgcgtc ctcccaggcg
     1501 cccggccggg agaagacgtg ccggggcatg atcttggcga gcgtgagccg cgaaacccct
     1561 tcggggaagg ggaacttgag caccagctcg acgttctgtg cgtcgatctt ccggacgtcc
     1621 ttcagccagc tcgcgaagaa ccccttgacg agggtctggg tcttcgggtc gaggatccgg
     1681 ccgaagacga acaccacgtc gtcggcggtg accggcttcc cgtcgtggaa cgtggccccg
     1741 gagcgcagcg tgaacttcca tgacgtgccg ccgagatcct tcggcacctg ggtggcgagc
     1801 gccgcgtagg gctcgcggga gatcggatcg gtgtcgagca ggccctcgta gatgtggttg
     1861 ttggcggcca tgctgaaggc ggacgcggtc tgtgtcggat cccagctgcc gtcgttccca
     1921 tagccgatga cggcggtcaa cgtccggttc ccgccgctgc ccccgccgcc ggtgtcgttg
     1981 gtggactccg ggcccgagga gcaggcggcc agcgacgagg agagcgcggc ggccgcgccc
     2041 agcgcgccgg agtacttcag gaacgaacgg cggtgcagcg ccggtacgtc gtgggtcgcg
     2101 tcgcgcacgg ttcctccagc gggagagtct ggaaagggtg aggagatacg acgtcctacg
     2161 tcctgggtca gcgtgaccat aggaggggcc gtgagggcgg tcaagggctc gcacacgaat
     2221 ggcgtatctg ccacaggtgc gaccaatgac ggtgcggacg gacgggagtt gacgccggat
     2281 ccacggagtc cggaccagag gtgggacgtg ggacgtccgg cgcgcgtacg atgcggcgca
     2341 tgtccgagga gaccgggaac agtcggatac ggcgcgaggt cgtgcagctg atcctcgacc
     2401 gcaggctccg ggccggcgcg ccgctgccca ccgagacgga gctgatggag gatctcggtg
     2461 tcagccgcaa ctccgtgcgc gaggcgctga aggcgttgca ggccctggac atcgtggaga
     2521 tcagacacgg ctacggcacc tacgtcggac gtgcctcgct gaccccgctg gtcgacggcc
     2581 tcaccttccg tacgctctcg cggcccgacg acgacacgga cgcgctggcg gagatcctcc
     2641 aggtccggga ggtcctggag gagggtctga tccgccgggt cacggcgacc ctctccgagg
     2701 cggagctgga ccggctggag tcggtggtgg cgcggatgga gacggccggc cgggcgggcc
     2761 gttcgttcgc cgaactggac cgggagttcc acgagttgct gtacgcgtcc ctcggcaacg
     2821 cctttgtgcc gcagctcctc ggcgccttct ggacggtgtt ccgccgggtc gcgggcgccc
     2881 gtgactggac ggacgacccg gccccggcgg tgacggcccg ccgccaccgc gacatcctca
     2941 cggccctgcg ggcccgggac gtcgagggcg cgcaacgggc gatggcggac cacttcaggg
     3001 gcatcgaggc gcgggcggcg gaggagtcgc ggggggtggg gtgagcgggg gagtgcctag
     3061 gctgggccga tgaccgacac ctggagtccc acggacgtgg gtgtgctgcg gctgccgtca
     3121 gggcgcctgg tccgcggccg aggcctgcgc cgccctcttc cggaggggca ggaaccgacg
     3181 tacgccgtgt atctgctcgg caagcggccg cccgaagtcc cctgggaggc gcactggttg
     3241 cgctggccgg acttccgcct gcccagcagc cgtacacagg cccgggaggt gctgaccgac
     3301 gcctggcggc gggccgccgc cgagcgcgtg gagatcgcct gcggcggggg ccgggggcgg
     3361 accggtacgg ccctcgcgtg cctggcggta ctcgacggcg taccccctca ggaggccgtg
     3421 gcgtacgtcc gcgcccacta cgaccggcat gcggtggaga cgccctggca gcggaggtac
     3481 gtacgacagg cgggctgctg gtagcggtcc cggcccaccc cgcgctcacc acgggtgcgg
     3541 tcaccccgta tgcggtcagg tcgccgtgag gggagtgtgc cgggcggatc gggtggtgag
     3601 ggactgcgcg tagcggcgca ggaggaggac ggcggtggtg gcgaggccgg tgaggaggcc
     3661 gagccagatg cccagggtgt cgagttccag ggcgtaggcg aggagccatg cggcggggag
     3721 tccgacggcc cagtagccga tgagggtgat gcggaagccg ctcctggtgt cgtcgaggcc
     3781 gcgcaggagt ccgacgccga tgttctgggc gcagtcgaag aactggagga aggcggtgac
     3841 gacgagcagg tgggtggcga tcgtcagggc ctgcccggag ccggattcca ggaacggggc
     3901 caggaccagc tcggggaggg tgaggtagac gacgccgacg acggtcatga cggccgcggc
     3961 gcaggcgagc gccgtgttct tgatgcggcc ggcgtcttcg taacggccta cggcgagttc
     4021 acggctgacg ttgatggacg cggcgtgcga gaggcccacg gcgacctgga agacgatgta
     4081 gacgagctgg ttgacagcgg tgtgcgcggc cagagcggcc ggtccgaagg atccggccat
     4141 gagcgcggtg agggagaaga acccggcctc cgacccgtag gtcgcggcga tcggcagccc
     4201 cagacgcagc agccgcctga ggacggccgg gtcggccttc atgacgtcca gggcgagcag
     4261 cggggcgagc gcgccgtcct tcctcgccga gacgtagagg gcgatgcagg tgaggacgta
     4321 cacgctggag gtggcgacac cgacgccggt cagccccatg cggggcaggc cccaggtgcc
     4381 gtggatgagg acccagttga ggccggcgtt gacggcgacg gaggcgacgg tgatccggag
     4441 cagggcctgg gggcgccgca ttccgaccgt gaactggcgg atcgcctgga accagagaca
     4501 gggcagcagg ccgggagcga gcgcgaacag catcgtctgg gcccggtcgg cgaccgcggc
     4561 gtcctggcct agccagggga gggcctgccc gatgaggatc atgaggacgg caccggcgag
     4621 gccggcgagg gtggccagcg ccaggctggc gcgcacgatg ccccgcatct cctcgtgtgc
     4681 ctcttcctgc gcgtggcccc ggccgtcgtc gtcacggccg gccgtccgct cggcctcggc
     4741 ctgctcggcc tgttctgccc gggccccggc ggcggcgatc tggttgccga ccgaggtgac
     4801 caggccgacg cccatggtgc gcagctggtt gaagatgacg agggccagcc cgcccgccgc
     4861 cagctcccgg gtgccgagca gacccatcat caccgtgtcc gtggtcgtca gggcgacctg
     4921 cgcgagctgg gtgaggatca gcgggacggc gagggcggcg agcgcgcggc tgtcgcggag
     4981 gagggtggtg agcatgaggg tcatcggttc ccgcggagct tggtgaggag ttcgtcgact
     5041 tcccgttccg ccgcgggatc gaggaggtcg cgggcccgca tccagtcgtc gttgaagacg
     5101 gtgtccatgt acttctcccc gccgtcattg atcagggcga ccatagtcgt gccgggcgga
     5161 agtccgggca ggcgggtcag ggcttcgtgg acgacgccgc cggcggagcc cccgatgagc
     5221 aggccggtgc gggccacggc ccggcaggtg gcgaacgcct cgacgtcacc gaccttggcc
     5281 ccttcgtcga tgaggccgaa gtcgaccaga gcaccgatcg gggcgccctc gggcgtgccg
     5341 gtgcccgact ggtagtagtc gtgcgccggg ccgccgaacg cgatcgaccc cttcggttcg
     5401 acgccgatgg tggtgaagcc gggtatgagg gtgcgcagtt cacgggccgt gccgcacagg
     5461 ccgccgccgg tgccgacggc cccgacgagg acgtcgaggc ggccgtcgag tgcctcgtgg
     5521 agttcgtggg cgacggggaa gtagccgacg ccgttgctgg ggttgttgtg ctgctcggtg
     5581 aagatggtgt tgtcctggcc gcgcgccatc tcctcggcga gttcctcacg ggcggcggtg
     5641 gcgagttcgt cggttccgtc gtccacgacg tggaccagtt cggcgcccag ggccttcatg
     5701 gcccgcagct tgtcgacggc ggcgtggttg tcgacgacgg cggtgaaggt gtagccgcgt
     5761 tcggcggcga tgacggccag gcccaggccg gtgttgccgg aggtggactc gatgatccgg
     5821 cctcccgcgc gcagttcgcc gcgctcctcg gcatcggtga tcatctggcg ggccatgcgg
     5881 atcttcgcgg tgccggtggg gttgaacatc tccagcttca gcagcaggcg gctgccggtc
     5941 tccgtggccg cgagttccag cagcggggtg tagccgatga ggtcggacac gcgggagacc
     6001 acggacgggc gccgcaggga tccgggcatc gaaattctcc tggggaatcg gtgggggacg
     6061 tcggctcggg atcagggggc gtgacggtcg aggcgccagc gcgggcgggc ccggtcggtg
     6121 tggtcgatga ccaccttggg cggcagcgcc aggtcgtgga agggggactc gttggagtcc
     6181 atctggtagc cggcggtgtt cgggtagacc agcaggtccc cggtgcgcgg tctgcggggg
     6241 aaggggacct tgcgccacgt gagcatgtcc gattccaggc aggtcgcggc gcccacggcg
     6301 gccggccaca ccgcgtccgg tgtgtcgggg tgggctgaca gcaggtgcgg gtcgggcagg
     6361 tactcgctgt tgaaccactg ctcggacagg ctcaggctgg tgccgttcac cgtcaggagc
     6421 tggtatccgt cccggtcctt gaccccctgg acacggaaga cggtgccgcc ggcccggtcg
     6481 agcagagcgc gtccgggctc cagcagaagc gtgatgccgg cgtcgttcag cagcgccgcg
     6541 aggcttggac ggtgcccttc ggggcgcgtg gccaggatcc ggcgcagggc gtccgccccg
     6601 gcgaccggtg agtggtaggg gtagaagccg tcggggtcga acgtcctgtc cgcgtggtag
     6661 tggccgccgt tctgtcgcgt caggaaggtg ttccagtcgg cggcggagct gtagctgacc
     6721 ggcaggccgc cgccgatgct gatgcggtcg gcctccagtc cgaggacgcg ggccttgagg
     6781 cacagttcga cgaggtgccc ggccaggtcg gcgcggagct tcacgtcgta tccggacagg
     6841 tggaagctga agccctccat acggaccgct tcgcccgccg tgacacagcg ctccagggcg
     6901 agggccactt cggcctcgcc caggccgaaa cggctgtggg gctgagcggg cggcaggcag
     6961 cgcagcagca gccgggccgg gcgcgtgcgg tccccggaca cggtggtgat gagcgtgtcg
     7021 agttcgtcga gcgcgtccac ggcgatcagg gcaccgtgcc ggacggccag tcccagcagt
     7081 gccaagtcct tggccggacc ggtgaccacg aggtgctccc cgcgcacacc gtgccccagg
     7141 gcctggcgca gttcggcggc ggaagcgacg tcgactcccg ccccgccggc ggcggatcgt
     7201 tccgcccaca cggctgcctt gttggccttc ttcgcgaagt acacgaaacc gtcgacgccg
     7261 gtctcgtcga ggacgctgtg cagggcgcgc aggttggcgt cgaaggcgtc gggcagcagg
     7321 aagtggaacg ggccgccgag cgcgtaggcg agttcctcca gcagcccgct gcccagcacg
     7381 gcgtcggcgg ccgggtcggg cagggcggga agggtgggaa gggcgggggg cccggtcacc
     7441 gccacagtgc cacctcggtg cccaggccct gttcgagggc gagctgtgcg aagcggtgcc
     7501 ccagcgcgat atcggtgacg acgagtccgc tgttgtaggc gaagatccgc tccgtcgcgg
     7561 tgcggcggcc cgcggtgtcg ccggtgatca cgggcgggaa ctcggcgtcg accgcgcgga
     7621 gttcgccgtc ggcgtcggcc atgtcgatgc cggtgacctt catctgggcc tcgctggtgg
     7681 cgatcacccg gtcggcccgg tgcagggccg acggggcgag accgtggccc acgaggatgg
     7741 acagggagcc cggcttgagc cggtccgccc cgaccgcggc cggggtgtgg ccgccggccg
     7801 tggccacgat gatgtcggcc tccgaggccg cggcccccgc gtcggtgacg atctccacgt
     7861 cccggtccgg gaagtgcgcc cgaagccgct cgcgcaccgc ggtgacgccc tcggggtggg
     7921 tgccgaagag catcagccgg tccagcccgg gcagcgtcgt cagcaggaag ggcagcgcca
     7981 gacggccctg ggtgcccgta ccgatgacca gggcgctgcg cgcaccgggg gcggcgcatt
     8041 cgcgggccag cagcgcggag accgccgggg tgcgcagcga tccgatccgg gagcagtcca
     8101 tcatcgccac gggcagcccg gtgacatcgt cgtagagggt cagcgtggtg tagtagtgct
     8161 gctcctcgcg ccccttgtcc aggccgtgct tgtaggaggt cttgacggcg acgacgtcgc
     8221 gggagccgtc ccggccgagc atcgcgtacg cgaccgaatg cccgtcccgc ggcttgacgg
     8281 tgagcttgcg ggggttgtcg gactcaccgg cgtgcagggt gcggtaggcg tcctccacgg
     8341 tggacaccac gtcggccagg gagatgtcga tcccggccag atcgccggtc gagaggatcc
     8401 gcaggtgccg gtcggcgcgg ggtatcggtt cggcggcggc ggtggtcgag gcgtcaggca
     8461 tggtcattcc tccaggaacg gggcggggtt cagcgcgcgt gggcttcgat cgcgctctgg
     8521 ccgtagccgt gctcgtgggc ttctgtcagg gggcgggtgc ggcgcccggg aacgcggacg
     8581 gaggcgcgct tgagccaccg gtcggtgccg tcgtagcggg cctggaaggg aacacggccg
     8641 tggacgacca ggtcgttgtc gacgaccagg acctcaccgg gagcgaggct gaccgcgacg
     8701 gagacacggg ccagttcttc cccgagccgc ccgtacgcgc tccggtaggc gtcgtccgcc
     8761 tggtcgaggg gggtgtaggc ggggtcgaag cgcagcgtga tcccgtcctc gctcgcgaac
     8821 agggcgggca cgggcggcgg ctcctcggcg tagccctggg cctcggcgta ggcgtcgtcc
     8881 ggcaggatgg ggagcaccgg gcgggtcagg gtgcgcacgt cccgctccga cagccgcgtc
     8941 ttgcggacgc tcgccgcggt ggtggcgatg tcgtcgtggt tgcgcatgca gccgagcatc
     9001 agcaggtggg cgcggccggg gtggaaggcg tcctcggtgt gggggctgag cagcacggtg
     9061 ctgctggcgc cggtctgctc ggtctcgtgg ccgggcgagg gcacgatgtt gtggacgaag
     9121 cggccgtcct gctgcccctc ccaggcgatc gggttgccca tcacggtggc cagcagcagg
     9181 agcgtgatgt cgtgggccgc tccgctgtct ccggccgtgg cccagctgtc cggcgtcgga
     9241 ccggccgcgg cgtcgtcgat gtcgaggccg cgcaggacga acagtccgtc gtcggtgtcg
     9301 acggggcggc agtggtgacg caggccgtcg ccgaacgcgt tcgcggtcgt cgcgatccgc
     9361 ttcagcagcg cgggggtcgt cgccgaggtg ccgaattcgg cgtgtatgtg ctctgtggct
     9421 tggcggagtt cactcacgga gtcggggtcg agctgacggg caggtgcggc tgccgtgctc
     9481 atggcgaagt ggtccgtttc gtgtgggggc aggggtgtcg ggcgccgtac gtcctgaagg
     9541 tgcggcgacg gtcaaccagt aggagggcag caggagttcg gcccacgcgg cgggcggctc
     9601 agctctcggg ggggcgttcg aacgctaaca ccgaacttag gttaggcata cctaattcac
     9661 aggccatatg atgtggccgg aagccggcgg ggggatgcgg cggggcgccc ctgtgaatgc
     9721 acgcgcccgg cgtgcgcccc gtatgcccag cgcgcaccct gcatgccgag atccccttgc
     9781 gggaacgatt gtcattaggg taggcaaacc taagcaccac tggggtgctc gggacgggga
     9841 tcggggacgt acgtgaacat caacaggcgt caagtgctgc tggccggcgg ggcgatgggc
     9901 gcgtcggcgc tgctggccgc ctgctccggg ggcggggacg acacgtcggc cgcctcctcc
     9961 gacaagggcg gcaagccccg caagggcggc acgctccgca tcggggcgct cggccgcgcc
    10021 ggcgccatca cccgtgaccc gcacggcact cagggcaacg agagcgacta cctgatcctc
    10081 gccctcgtct acgacaccct caccgtcccg ggcgccgacc ccaacaccaa gcctcggctg
    10141 gccgcttcgt gggagccgtc gaaggacctg aagacctggc gcttcaagct ggccgaggac
    10201 gccgccttcc acgacggcag cccggtcacc gccgacgacg tcgtgtggtc gctgcggcgg
    10261 ctgcgcaaca ccccctccgg ggccgcccgc ctgcccggca tcaaggccga gaacatcacc
    10321 gccgacggga aggacacggt ggtgctggtc tccgactacg cgaacgccga actcccgccc
    10381 ctgacccggc tgacgacgtt cgtactgaag aagggcacat cggacaagga gttggcgaag
    10441 gcgccgggca ccgggccgtt caagctcgac cggtaccgcg ccggcaacgc gcgcctggtg
    10501 cgcaacgacc agtggtacgg cggcaccgtg tacctcgacg cgatcgaggt gacgatgttc
    10561 gagacgccgc aggcgatggc caacgcgctg ctcgccgggc agatcgacgt cgcctccaac
    10621 gcgggtgcgg tcgccgcgcg cacggcaaag tcccgcaagg acgtccaggt ggtgcgccgc
    10681 cccgacgaca tgtcgatgcc cctcgtcatg cgcaccgcgg acggcccgtt cgccgatgcc
    10741 cgggtgcggg aggcgatgcg tctggtggtg gaccgcgagg ccatggtcaa gcaggtcctg
    10801 tccggatacg gaaccgtcgc caacgacatc atgggaaccg gcgaccccgg ctacgccaag
    10861 gacgtcccgc agcgggagcg tgacctggcc gaggccgagc ggctgctctc cgaggcgaag
    10921 ttcgacctgt ccaagaccta cgagctggtc accaccgagg acatctcggg gctcgccgag
    10981 tccgccaccc tgttcgcctc ccaggcccgc gaggccggaa tcaagatcaa ggtcgtcaag
    11041 caggagtccg gcgcgttcta cgagaagacc tggctcaagg gcgacctcta cacgacgtac
    11101 tggggcacca acgactcggt ggtgttcttc gcgtccaaga ccctggtcag cgaggccggg
    11161 cagaacgaag ccggcttcgc ggacaagaag ttcgacgcga cctaccgcaa ggtgatcgcc
    11221 accgcggacc cgaaggcccg cgccgaggta ctcaaggagc tccagcggat cgagtacgac
    11281 cggtccggct atctgctgtg gggcatggcc gacggcatcg acctggccgc ctccaaggtc
    11341 cgtggtctgc ccgagctcgc cggctacggc cgcgtccagc tcgagaacgt gtggctgggt
    11401 tgagccggtt gtccaaggat ggcgtgacgg ccgccccgcc gtgggcggcc accgtgtcgc
    11461 gtcgcgtgct gccgccgctc gcccgcgcgg gtgcggcgct ggcccgccgg gtactcatgc
    11521 tcgcgatcct gatcgcggcc gtgttcgccg cggtggagct gttgcccggg gacgcggcga
    11581 acgcgacctc cgagcgtggg gacagcgccg cggatgtcgc ggcacgccgt catctgctcg
    11641 gcctggaccg gcccctgtgg gaacgcttcg ccgactggat gacgggtctg cccaccggcg
    11701 acctgggcac cagcgcccgc ggccagaaag tcaccgacct gctggccgac ccctttccca
    11761 acaccctgct gctggcgacg gtcgccttcg tcctcaccgc cgcgctctcg ctggcgctcg
    11821 gctgctggac cgccgcccgg ccgggctcga tgaccgaccg gatcgtcggc cacgccgcca
    11881 cctcggcgtt cgccatcccc gaattcgtcg tctccgtcgg cctgctcatc gtgctgtcgc
    11941 tgtggacggg ctggctgccc gccgtgaccc tgaccggtgc cgacggtgcc cccgccacct
    12001 ggaccatgct gatcatgccg gccctcgcgc tggtcatccc gcagaccgga tggaacacca
    12061 ccatcgtgcg cggggcgctc gccgaccagg cggccacccc gcacgtcgag gccgcccagc
    12121 tcgacggcct gtcgccgcac cgcgtcatct ggcgccacgc gcttcccgga gccgtcccgg
    12181 ccgtcgccac cggcctggcc acctccaccg ggatgctgct gggcggcgcg gtggtggtgg
    12241 agacgctctt caactacccg ggcatcggca gtgtgctggc cggcgccgtc gccaaccgcg
    12301 acacccccct catcgccggc gtcgtcgtct gcgccggcgc cgccatcagc ctggtcctgc
    12361 tggccgccga cgtcatccgc gcccgagtcc tgggagcctc ctcatgagcg tcgccacgac
    12421 gggccgcagg ccggccacgg ccgacgggcg aggccgtgtg ctgccccgcg tcacgcccgc
    12481 catcctcctg gtcctgctcg ccctgaccgg cccgtacctc gccgcccacc ccctggacaa
    12541 gcccgtcacc gcccccttcg ctccccccgg cgacggggcg ccgctgggcg gggaccagct
    12601 cggccgcgat gtgctcagcc gactgctcca cggcggcacc gccctgatcg gcagcgccct
    12661 cctggtcgcc ttcgtcgtca ccctgctggc cgccctgatc ggctgtttcg ccgtcctgca
    12721 ccccgtcgtg ggacgcgccg tggagcggac cgccgacgtg ttcatcctgc tgccgcccgt
    12781 cctgggcatc atgctcatcg cactggcctg gcccggcggc ggtcgatggg ccgtcatcag
    12841 cgcagccacc gtcctgggca tcccgtacgc cgtacgcgtc gtcgcaggcg ccgccgcccc
    12901 cctggccacc gccggatacg tcgaagccgc cctggcgcgc ggggaaagcg tcacctacac
    12961 cgccacccgc gaactcctgc cgaacctgcg gggcaccgtc ctcgccctgt tcggcctgcg
    13021 cttcgtcgaa gccgtctacg tcatctcgat ggccggcttc ctccagatcg gcccccagcc
    13081 cccggccgcg gactgggcgc tgatgatccg cgagaacgcc ccgggcatcc tcctcaaccc
    13141 gtgggccgtc gtcgccccca gcctgaccat cgccctgctc gccatcagcg tcaacctcgc
    13201 ggccacctcc ctcgcgcccc gctccgcacg caaggcggtg accaccccgt gaccacgccc
    13261 acccccgctc cggccaccgg ccacaccccc gacacccctg cctccggcgc ggccggaaca
    13321 cccgcgaccc tggtgacggc gaccgacgtc ggcatccgca tccccgacgg tcccgtcctc
    13381 ctgcccccca ccagcctgac cgtccgcgcc ggcgagatca ccgccctgac cggggcctcc
    13441 ggttccggca agaccactct g
//
