LOCUS       NC_003155              29773 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6369180
            Orig. end                         :: 6398953
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29773
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="28"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..29773
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29773
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[14000:15773](-)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(14001..15773)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     misc_feature    complement(345..360)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.74"
                     /tool="antismash"
     misc_feature    complement(768..782)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    769..783
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    complement(847..858)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    852..869
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.83"
                     /tool="antismash"
     misc_feature    complement(855..872)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.5"
                     /tool="antismash"
     gene            1050..2105
                     /db_xref="GeneID:41542346"
                     /locus_tag="SAVERM_RS27135"
                     /old_locus_tag="SAV_5257"
                     /old_locus_tag="SAVERM_5257"
     CDS             1050..2105
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542346"
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660189.1"
                     /locus_tag="SAVERM_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5257"
                     /old_locus_tag="SAVERM_5257"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_010986661.1"
                     /transl_table=11
                     /translation="MAGHGARGRSGGRPTLEEVAARAGVGRGTVSRVINGSPRVSDATR
                     AAVEAAVAELGYVPNTAARALAANRTDAIALVVPEPETRFFAEPYFSDMLKGVGSALSE
                     TEMQLLLIFAGSDRERQRLAQYLAAHRVDGVLLVSVHADDPLPDLLAQLEIPAVISGRR
                     SAEETLPSVDSDNFGGGRVAVEHLIDQGRRNVVHLAGRLDVYGAQRRVDGYREALRDAG
                     RPVDESLIVAGDFTEEGGRRAMTELLARCPALDAVFAGSDVMAAGARQVLREAGRRIPD
                     DVALVGYDDSAIARHMDPPLTSVRQPIEEMGRAMIDLLLDEIADRRPAVSRGLERRQLV
                     LPSELVRRASS"
     gene            complement(2189..2797)
                     /db_xref="GeneID:41542347"
                     /locus_tag="SAVERM_RS27140"
                     /old_locus_tag="SAV_5258"
                     /old_locus_tag="SAVERM_5258"
     CDS             complement(2189..2797)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542347"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020124703.1"
                     /locus_tag="SAVERM_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5258"
                     /old_locus_tag="SAVERM_5258"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_010986662.1"
                     /transl_table=11
                     /translation="MPAHPEPAEPPEPPGPAASVGTTGTTGTTGTTGTTGTARIIRTAR
                     LDLLPLRVEHAEEMAQVLGDPALHAFIGGVPDTPAALRARYARLAAGSPHPGVRWVNWV
                     LRRRADACLVGTVQATVTGEVAEIAWVVGTPWQGRGFASEAAQGLVDRLTRQSGSVRIV
                     VAHVHPDHHASASVAAAAGLSPTDREQDGEIRWELTVRA"
     gene            complement(2938..3333)
                     /db_xref="GeneID:41542348"
                     /locus_tag="SAVERM_RS27145"
                     /old_locus_tag="SAV_5259"
                     /old_locus_tag="SAVERM_5259"
     CDS             complement(2938..3333)
                     /codon_start=1
                     /db_xref="GeneID:41542348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949228.1"
                     /locus_tag="SAVERM_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5259"
                     /old_locus_tag="SAVERM_5259"
                     /product="hypothetical protein"
                     /protein_id="WP_037649853.1"
                     /transl_table=11
                     /translation="MLRSARGRVVTTVLAATALLLGAQGTATAAAQRANTEGGYALWNA
                     DPDGATPGDSVRACDTTTDGWGIEARLDINRDGTIDRTASTRGRTAPYCTAWKSGDIPE
                     GAPVAVYAVTVRGDDTKDKGGLIWSHA"
     misc_feature    3386..3399
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     tRNA            complement(3525..3597)
                     /anticodon=(pos:complement(6372742..6372744),aa:His,
                     seq:gtg)
                     /db_xref="GeneID:41542349"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SAVERM_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAV_t49"
                     /old_locus_tag="SAVERM_t49"
                     /product="tRNA-His"
     gene            complement(3525..3597)
                     /db_xref="GeneID:41542349"
                     /locus_tag="SAVERM_RS27150"
                     /old_locus_tag="SAV_t49"
                     /old_locus_tag="SAVERM_t49"
     misc_feature    3639..3650
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    3640..3658
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            complement(3715..4317)
                     /db_xref="GeneID:41542350"
                     /gene="orn"
                     /locus_tag="SAVERM_RS27155"
                     /old_locus_tag="SAV_5260"
                     /old_locus_tag="SAVERM_5260"
     CDS             complement(3715..4317)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0000175 - 3'-5'-RNA exonuclease activity
                     [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542350"
                     /gene="orn"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958173.1"
                     /locus_tag="SAVERM_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5260"
                     /old_locus_tag="SAVERM_5260"
                     /product="oligoribonuclease"
                     /protein_id="WP_010986664.1"
                     /transl_table=11
                     /translation="MNDRMVWIDCEMTGLSLSDDALIEVAALVTDSELNVLGEGVDIVI
                     RPPDAALETMPEVVRTMHTASGLLDELAAGTTLADAEAQVLAYVREHVKEPGKAPLCGN
                     SVGTDRGFLARDMSALETYLHYRIVDVSSVKELARRWYPRAYFNSPEKSGNHRALADIR
                     ESIAELRYYREAIFVPQPGPDSETARTIAAKHVLPAQ"
     gene            complement(4469..5749)
                     /db_xref="GeneID:41542351"
                     /locus_tag="SAVERM_RS27160"
                     /old_locus_tag="SAV_5261"
                     /old_locus_tag="SAVERM_5261"
     CDS             complement(4469..5749)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542351"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486515.1"
                     /locus_tag="SAVERM_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5261"
                     /old_locus_tag="SAVERM_5261"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_010986665.1"
                     /transl_table=11
                     /translation="MSHDSTAAPDAAARKLSGRRRKEIVAVLLFSGGPIFESSIPLSVF
                     GIDRQDAGVPRYRLLVAAGEEGPLRTTGGLELTAPHGLEAISRAGTVVVPAWRSITSPP
                     PEEALDALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVD
                     PRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGNEAAGALARRLVVPPRRSGGQERYLD
                     RSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWL
                     ITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARRPQ
                     GERPVDPDSVVGPPPALPQEAPVPMQTRRTAAASSLGPAASLSTEPGKHGSHGSHGSHG
                     SHGSHGSHGSELYAAGRPSLPGQRSAP"
     misc_feature    complement(5075..5077)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(5937..5950)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.26"
                     /tool="antismash"
     misc_feature    complement(6089..6103)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.03"
                     /tool="antismash"
     gene            complement(6128..6565)
                     /db_xref="GeneID:41542352"
                     /locus_tag="SAVERM_RS27165"
                     /old_locus_tag="SAV_5262"
                     /old_locus_tag="SAVERM_5262"
     CDS             complement(6128..6565)
                     /codon_start=1
                     /db_xref="GeneID:41542352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003377.1"
                     /locus_tag="SAVERM_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5262"
                     /old_locus_tag="SAVERM_5262"
                     /product="hypothetical protein"
                     /protein_id="WP_010986666.1"
                     /transl_table=11
                     /translation="MPVSRTSPTSRTSPDDLRRTPAQGAPPSPARPSAAPPSDTASDVV
                     RWAVFSCALVPVVLVWYGTSLAGAAGTALGLAAVTGVCRMLLRQSERGAARLSDEAARQ
                     RVPHRGRHGRSGWQGTGGAHGKSGSGAHRGGRHTAGNTPVD"
     misc_feature    6595..6610
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.61"
                     /tool="antismash"
     gene            6909..7436
                     /db_xref="GeneID:41542353"
                     /locus_tag="SAVERM_RS27170"
                     /old_locus_tag="SAV_5263"
                     /old_locus_tag="SAVERM_5263"
     CDS             6909..7436
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325548.1"
                     /locus_tag="SAVERM_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5263"
                     /old_locus_tag="SAVERM_5263"
                     /product="universal stress protein"
                     /protein_id="WP_010986667.1"
                     /transl_table=11
                     /translation="MAGHEFFEPADRKRPVADPTAAEPLAAEEPRHSCDPAFKHGVVVG
                     FDGSTSSERALAYAIGMAHRSGSGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLG
                     LELACAEYLAEVPWILVERGGDICHELEEVGREYEADAIVVGSTHGIVGRLFGSVAGRL
                     AKRAQRPVIVIP"
     gene            7587..8153
                     /db_xref="GeneID:41542354"
                     /locus_tag="SAVERM_RS27175"
                     /old_locus_tag="SAV_5264"
                     /old_locus_tag="SAVERM_5264"
     CDS             7587..8153
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001032.1"
                     /locus_tag="SAVERM_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5264"
                     /old_locus_tag="SAVERM_5264"
                     /product="GPR1/FUN34/YaaH family transporter"
                     /protein_id="WP_010986668.1"
                     /transl_table=11
                     /translation="MDNDVSAGSTTTVVGRLTLGITLLAFGLGYADVIDGVTAADAVSV
                     AHYVGGVALFVAGLLALRERDAASGTAFSALGALWFTWAVTAGSRMSDNAAGLFLLLFA
                     LVALSLTLGAAGGVLDQGAYGLFAVSLLLLAIAHFAGNDGLGRIGGWFAVAAGAVAWYA
                     ATAALAHWPTALPRRAAGRGVTAAG"
     gene            complement(8258..10075)
                     /db_xref="GeneID:41542355"
                     /gene="glmS"
                     /locus_tag="SAVERM_RS27180"
                     /old_locus_tag="SAV_5265"
                     /old_locus_tag="SAVERM_5265"
     CDS             complement(8258..10075)
                     /EC_number="2.6.1.16"
                     /GO_function="GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA]"
                     /GO_process="GO:0006040 - amino sugar metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542355"
                     /gene="glmS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980526.1"
                     /locus_tag="SAVERM_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5265"
                     /old_locus_tag="SAVERM_5265"
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="WP_010986669.1"
                     /sec_met_domain="GATase_7 (E-value: 1.6e-16, bitscore:
                     59.2, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIVGYIGKRDVTPLLLEGLQRLEYRGYDSAGIVVTSPKTAGLK
                     MVKAKGRVRDLEAKVPARFKGTTGIAHTRWATHGAPSDLNAHPHMSQDNQVAVVHNGII
                     DNASDLRKKLEADGVEFLSETDTEVLTHLIARSQQEKLEDKVREALRVIEGTYGIAVMH
                     ADFPDRIVVARNGSPVVLGIGEKEMFVASDIAALVTHTRQIVTLDDGEMATLKADDFRT
                     YTTEGTRTTAEPTTVEWEAASYDMGGHDTYMHKEIHEQADAVDRVLRGRIDDRFSTVHL
                     GGLNLDAREARAVRRVKILGCGTSYHAGMIGAQMIEELARIPADAEPASEFRYRNAVVD
                     PDTLYIAVSQSGETYDVLAAVQELKRKGARVLGVVNVVGSAIAREADGGMYVHAGPEVC
                     VVSTKCFTNTTVAFALLALHLGRTRDLSVRDGKRIIEGLRKLPAQISEILDQEDEIKKL
                     AAQYAEARSMLFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEPALPT
                     VAIVPDDDLLEKNRAALEEIKARSGKILAVAHQEQEKADQTIVVPKNEDELDPILMGIP
                     LQLLAYHTALALGRDIDKPRNLAKSVTVE"
     misc_feature    10053..10067
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.33"
                     /tool="antismash"
     gene            complement(10113..10370)
                     /db_xref="GeneID:41542356"
                     /locus_tag="SAVERM_RS27185"
                     /old_locus_tag="SAV_5266"
                     /old_locus_tag="SAVERM_5266"
     CDS             complement(10113..10370)
                     /codon_start=1
                     /db_xref="GeneID:41542356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131788.1"
                     /locus_tag="SAVERM_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5266"
                     /old_locus_tag="SAVERM_5266"
                     /product="hypothetical protein"
                     /protein_id="WP_010986670.1"
                     /transl_table=11
                     /translation="MHDELVDHLTRSTPLNRGEALRVIQDVLAYFDETTEEYVRRRHRE
                     LQAQGLVNATIFERIEADLKYRAVAPPELTLRQLRRIVYG"
     gene            10536..12098
                     /db_xref="GeneID:41542357"
                     /locus_tag="SAVERM_RS27190"
                     /old_locus_tag="SAV_5267"
                     /old_locus_tag="SAVERM_5267"
     CDS             10536..12098
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006376591.1"
                     /locus_tag="SAVERM_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5267"
                     /old_locus_tag="SAVERM_5267"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_171033219.1"
                     /transl_table=11
                     /translation="MGVPEKLAERMSMAEQHEYLRARFSRRNMIRGGAVTLGAVAGGAF
                     VPGATARAAVPAQRAAASAEKVDGALVAPFGRHLAYGTDPRTEMTVSWQVPVAVKKPYI
                     RIGAHPWDLSRKIEAEVRALHTPAGVGASGDHTQYYLHARLTHLRPGRTYYYGVGHDGF
                     DPAAPHLVGTLGTFTTAPAHSEPFTFTAFGDEGVGYHGLANDALLLGQNPAFHLHAGDI
                     AYADPAGAGKTGDTGFDSRIWDQFLAQTESVAKSVPWMVSYGNHDMEAWYSPNGYGGEE
                     ARWQLPENGPDKANLPGVYSFVHGNTAVISLDANDVSFEIPANLGISGGTQTKWLEARL
                     KKYRAAKDIDFIVVFFHHCAYCTSTAHSSEGGVRQEWVPLFEKYTVDLVINGHNHQYER
                     TDVIKGDEVTKKLPIGGTAYPETEGVVYVTAGAAGRSLYAFTAPDSYEGHENDVESVSA
                     FVNLKGGKQNETVAWSRVRYLDYSFLRVDVTPAAKGRTATMRVRGIAESGVEIDHFTVA
                     RRV"
     gene            complement(12120..12242)
                     /db_xref="GeneID:91294929"
                     /locus_tag="SAVERM_RS45375"
     CDS             complement(12120..12242)
                     /codon_start=1
                     /db_xref="GeneID:91294929"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS45375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255344842.1"
                     /transl_table=11
                     /translation="MAEVIQKNGAGVQARPPRPTAPAADVPPQEPAKQAVLERR"
     misc_feature    complement(12213..12229)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.65"
                     /tool="antismash"
     misc_feature    complement(12274..12289)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.1"
                     /tool="antismash"
     gene            12362..13951
                     /db_xref="GeneID:41542358"
                     /locus_tag="SAVERM_RS27195"
                     /old_locus_tag="SAV_5268"
                     /old_locus_tag="SAVERM_5268"
     CDS             12362..13951
                     /codon_start=1
                     /db_xref="GeneID:41542358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056580.1"
                     /locus_tag="SAVERM_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5268"
                     /old_locus_tag="SAVERM_5268"
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="WP_010986672.1"
                     /transl_table=11
                     /translation="MRQHHRTPRLLGTLLLVAAAGFSVAGSAPAAAAKTASPLGQVVPA
                     PASVDPGGSPYRITRDTRIRVDDSREVRQVGEYLAGILRPSTGYRLPVASQGGGGIRLR
                     LGERSLGDEGYRLDSGRNGVTITAAAPAGLFHGVQTLRQLLPAAVEKNSVQPGPWLVAG
                     GTIKDTPRYGYRGAMLDVSRHFFDVGQVKRYIDELALYKVNKLHLHLSDDQGWRIALDD
                     WPRLTTYGGSTQVGGGRGGFYTKAQYTEIVRYAASRHLEVVPEIDMPGHTNAALASYAE
                     LNCDGTAPPLYTGTDVGFSSLCVGKPVTYDFVDDVIRELAALTPGRYLHIGGDEAHSTS
                     HADYVAFMDKVQPVVAKYGKTVIGWHQLTGATPAKGALAQYWGLDDTSAAEKAQVVKAA
                     QNGTGLVLSPADRIYLDMKYTADTPLGQDWAGLVEVRRAYDWDPGTYLAGAPGASIRGV
                     EAPLWTETIVTGADIDYMVFPRLPGVAELGWSPASTHDWDTYKVRLAAQGPRWEARGIR
                     YYRSPQVPWPGA"
     gene            complement(14001..15773)
                     /db_xref="GeneID:41542359"
                     /locus_tag="SAVERM_RS27200"
                     /old_locus_tag="SAV_5269"
                     /old_locus_tag="SAVERM_5269"
     CDS             complement(14001..15773)
                     /codon_start=1
                     /db_xref="GeneID:41542359"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123257.1"
                     /locus_tag="SAVERM_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5269"
                     /old_locus_tag="SAVERM_5269"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_010986673.1"
                     /sec_met_domain="IucA_IucC (E-value: 7.3e-80, bitscore:
                     266.9, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSDAVAHLSPERWERANRLLVRKALAEFAHERLLTPEAAGDGA
                     YVVRSDDGLTRYRFTARLRSLDHWQVDAESITRHRDGAELPVAALDFFIELKKSLGLSD
                     EVLPVYLEEISSTLSGTCFKLTKPQIPVAELAEAGFQAIETGMTEGHPCFVANNGRLGF
                     GVHEYLSYAPETASPVRLVWLAAHRSRAAFTAGVGIEYESFLREELGEQTLNRFAATLR
                     DQGLDPDDYLLIPVHPWQWWNKLSVTFAAEVAQRRLVCLGEGDDEYLAQQSIRTFFNKS
                     APEKHYVKTALSVLNMGFMRGLSAAYMEATPAINDWLAQLVDNDPVLKSTGLSVIRERA
                     AVGYRHLEYEAATDRYSPYRKMLAALWRESPVPALQEGESLATMASLVHVDHAGASFAG
                     ALIERSGLSPVEWLRRYLRAYFTPLLHSFYAYDLVYMPHGENVILVLKDGAVQRAIYKD
                     IAEEIAVLDPQAVLPPAVERIRVEVPEDKKLLSIFTDVFDCFFRFLAADLADEGVLGEE
                     DFWRTVAESVREYQESTPELADKFRQYDMFAPEFALSCLNRLQLRDNKQMVDLADPSGA
                     LQLVGNLKNPIAGL"
     gene            complement(15770..16321)
                     /db_xref="GeneID:41542360"
                     /locus_tag="SAVERM_RS27205"
                     /old_locus_tag="SAV_5270"
                     /old_locus_tag="SAVERM_5270"
     CDS             complement(15770..16321)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542360"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203: putative siderophore biosynthesis protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131548.1"
                     /locus_tag="SAVERM_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5270"
                     /old_locus_tag="SAVERM_5270"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_010986674.1"
                     /transl_table=11
                     /translation="MSTPDIGTFTVRPLDPTRDAELLHGWVTHPKSAFWMMQEARLHDV
                     EREYMAIAASEYHDAFLGLLDDEPVFLMEKYDPAHVELVGLYEPEPGDVGMHFLVAPTD
                     TPVHGFTRAVITAVMEHLFADPATRRVVVEPDVGNKAVHALNEAVGFVPEREIQKPEKK
                     ALLSFCTREQFAAAVRGAAV"
     gene            complement(16318..17589)
                     /db_xref="GeneID:41542361"
                     /locus_tag="SAVERM_RS27210"
                     /old_locus_tag="SAV_5271"
                     /old_locus_tag="SAVERM_5271"
     CDS             complement(16318..17589)
                     /codon_start=1
                     /db_xref="GeneID:41542361"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080: lysine/ornithine N-monooxygenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486497.1"
                     /locus_tag="SAVERM_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5271"
                     /old_locus_tag="SAVERM_5271"
                     /product="lysine N(6)-hydroxylase/L-ornithine
                     N(5)-oxygenase family protein"
                     /protein_id="WP_010986675.1"
                     /transl_table=11
                     /translation="MEKTSAGKTYDFVGIGLGPFNLGLACLTEPIAELEGVFLESKPDF
                     EWHSGMFLEGAHLQTPFMSDLVTLADPTSPYSFLNYLKESGRLYSFYIRENFYPLRVEY
                     DDYCRWAASKLSSIRFGTTVTEVTYEDDVYVVRTEAGDLYRARHLVLGTGTPAYLPEAV
                     QGLGGDHIHNSRYMQHKQELQAKESITLVGSGQSAAEIYYDLLSEIDVHGYRLNWVTRS
                     PRFFPLEYTKLTLEMTSPEYIDYFHALPEPTRYRLTAEQKGLFKGIDGDLINEIFDLLY
                     QKNLGGPVPTRLLTNSALNGATYENGTYTLTLRQEEQEKEYELRSQGLILATGYRYAEP
                     EFLKPVRDRLRYDAQGNFDIARNYAIDTTGRGVFLQNAGVHTHSITSPDLGMGAYRNAY
                     IIRELLGTEYYPVEKTIAFQEFAV"
     gene            complement(17594..19036)
                     /db_xref="GeneID:41542362"
                     /gene="desA"
                     /locus_tag="SAVERM_RS27215"
                     /old_locus_tag="SAV_5272"
                     /old_locus_tag="SAVERM_5272"
     CDS             complement(17594..19036)
                     /EC_number="4.1.1.18"
                     /NRPS_PKS="Domain: Aminotran_5 (141-265). E-value: 7.1e-08.
                     Score: 23.7. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS27215_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:41542362"
                     /gene="desA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_099499428.1"
                     /locus_tag="SAVERM_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5272"
                     /old_locus_tag="SAVERM_5272"
                     /product="lysine decarboxylase DesA"
                     /protein_id="WP_037649847.1"
                     /transl_table=11
                     /translation="MRSHLLNDTTADRYRRSVTEGIERVAAKLATTASPFTGITVDALA
                     PRIERIDLDRPLHDTTAVLDELEEVYLRDAVYFHHPRYLAHLNCPVVIPAVVGEAILSA
                     VNSSLDTWDQSAGGTLIERKLIDWTNERIGLGPAADGVFTSGGSQSNLQALLLAREEAK
                     SDDLARLRVFASEVSHFSVKKSAKLLGLSADSVVSIPVDHDKRMQTVALAHELDRCKRD
                     GLLPMAVVATAGTTDFGSIDPLPEIAELCAQFGAWMHVDAAYGCGLLTSLKHRDRIDGI
                     ERADSVTVDYHKSFFQPVSSSAVLVRDASTLRHATYHAEYLNPRRMVEERIPNQVDKSL
                     QTTRRFDALKLWMTLRVMGADGIGQLFDEVCDLAAEGWKLLAADPRFDVVVEPSLSTLV
                     FRYIPAAVTDPAEIDRANLYARKAIFASGDAVVAGTKVGGRHYLKFTLLNPETTADDIT
                     AVLDLIAGHAEQYLGESLDRAS"
     aSDomain        complement(18242..18613)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS27215_Aminotran_5.1"
                     /evalue="7.10E-08"
                     /label="SAVERM_RS27215_Aminotran_5.1"
                     /locus_tag="SAVERM_RS27215"
                     /protein_end="265"
                     /protein_start="141"
                     /score="23.7"
                     /tool="antismash"
                     /translation="VFTSGGSQSNLQALLLAREEAKSDDLARLRVFASEVSHFSVKKSA
                     KLLGLSADSVVSIPVDHDKRMQTVALAHELDRCKRDGLLPMAVVATAGTTDFGSIDPLP
                     EIAELCAQFGAWMHVDAAYG"
     misc_feature    19111..19129
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 26.45"
                     /tool="antismash"
     misc_feature    complement(19116..19134)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 33.36"
                     /tool="antismash"
     gene            complement(19174..20046)
                     /db_xref="GeneID:41542363"
                     /locus_tag="SAVERM_RS27220"
                     /old_locus_tag="SAV_5273"
                     /old_locus_tag="SAVERM_5273"
     CDS             complement(19174..20046)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0055072 - obsolete iron ion homeostasis
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542363"
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672885.1"
                     /locus_tag="SAVERM_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5273"
                     /old_locus_tag="SAVERM_5273"
                     /product="siderophore-interacting protein"
                     /protein_id="WP_010986677.1"
                     /transl_table=11
                     /translation="MTTAVAAPFRFFSLQVVRTRRLGPSLLRVTFTGADLHAFASDGRD
                     QSLSLFLPHPGQTEPAVPIELGDNWWQGWRELPDDVRAVMRSYTLRALRQDAHGNTVEI
                     DIDFVLHGVEPGAAAPAGPASRWASRATAGDRVLLLGPAVADNRAIRFRPPEGTDLVVV
                     WADETAVPAASAILEWLPAGTRAKVWLEVHDAGDIQDLTTEADAEITWLVHSERETRGE
                     GSPMALDAVRAAAFPPAERPYAWIAGESGCVKELRRHLVRERGIDRRQVTFVGYWRQGL
                     SEEQLREQE"
     gene            complement(20122..21171)
                     /db_xref="GeneID:41542364"
                     /locus_tag="SAVERM_RS27225"
                     /old_locus_tag="SAV_5274"
                     /old_locus_tag="SAVERM_5274"
     CDS             complement(20122..21171)
                     /codon_start=1
                     /db_xref="GeneID:41542364"
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486492.1"
                     /locus_tag="SAVERM_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5274"
                     /old_locus_tag="SAVERM_5274"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_010986678.1"
                     /transl_table=11
                     /translation="MSNARATHLTRRGILAAGGAFGLGAALAACGDDKAKDSGSDSGTA
                     AAKSGPWSFKDDRGQTAKADKTPSSIVAFTGVAAALYDYGVDVKGVFGPTKTKDGKADV
                     QAGDLDISKVTILGNEYGQFNIEKYAALAPDLLITTMFDDAGSLWYVPAESKKKVLAVG
                     APSVGISVYDRQLTEPLQRMLALAKSLGADTSSATITKAKKRFEDAAARLRAATKANPD
                     IKVLAGSASQDIFYVSTSNLSIDLEYFKALGVNFVEPSASALKASGGWFENLSWENVDK
                     YKADVIIMDNRSSTIQPADITKATWKKLPAVKAGQVTARNPEPILSYDKCAPLLEDLAE
                     AIEKAKKVS"
     misc_feature    complement(21165..21179)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.9"
                     /tool="antismash"
     misc_feature    complement(21223..21241)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 30.94"
                     /tool="antismash"
     gene            complement(21305..22465)
                     /db_xref="GeneID:41542365"
                     /locus_tag="SAVERM_RS27230"
                     /old_locus_tag="SAV_5275"
                     /old_locus_tag="SAVERM_5275"
     CDS             complement(21305..22465)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542365"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325537.1"
                     /locus_tag="SAVERM_RS27230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5275"
                     /old_locus_tag="SAVERM_5275"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_010986679.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.7e-36, bitscore:
                     123.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.5e-21, bitscore:
                     73.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-46, bitscore:
                     157.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHRLTPELEELRRTVEEFAHDVVAPKIGDFYERHEFPYEIVREM
                     GRMGLFGLPFPEEYGGMGGDYLALGIALEELARVDSSVAITLEAGVSLGAMPIHLFGTD
                     AQKAEWLPRLCSGEILGAFGLTEPDGGSDAGATRTTARLDESTNEWVINGTKCFITNSG
                     TDITGLVTVTAVTGRKPDGKPLISSIIVPSGTPGFTVAAPYSKVGWNASDTRELSFADV
                     RVPAANLLGEQGRGYAQFLRILDEGRIAISALATGLAQGCVDESVKYAGERHAFGRNIG
                     AYQAIQFKIADMEMKAHMARVGWRDAASRLVAGEPFKKEAAIAKLYSSTVAVDNAREAT
                     QIHGGYGFMNEYPVARMWRDSKILEIGEGTSEVQRMLIARELGLVG"
     gene            complement(22471..23418)
                     /db_xref="GeneID:41542366"
                     /locus_tag="SAVERM_RS27235"
                     /old_locus_tag="SAV_5276"
                     /old_locus_tag="SAVERM_5276"
     CDS             complement(22471..23418)
                     /codon_start=1
                     /db_xref="GeneID:41542366"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004987752.1"
                     /locus_tag="SAVERM_RS27235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5276"
                     /old_locus_tag="SAVERM_5276"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_010986680.1"
                     /sec_met_domain="HMGL-like (E-value: 4.8e-50, bitscore:
                     169.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPESGLPMVVPAQDLPARVRIHEVGARDGLQNEKGTVPTEVKA
                     EFIRRLADAGLTTIEATSFVHPKWVPQLADAEQLFPLVSDLPVALPVLVPNERGLDRAL
                     VLGARQVAVFASATESFAKANLNRTVDEALAMFEPVVTRAKAADVRVRGYLSMCFGDPW
                     EGAVPIHQVVRVCKSLLDMGCDELSLGDTIGVATPGHVQDLLAELTEEGVPTRAIGVHF
                     HDTYGQALANTLAALQHGVTTVDASAGGLGGCPYARSATGNLATEDLVWMLQGLGIDTG
                     VDLARLTATSVWMAERLGRPSPSRTVRALSHKEQ"
     gene            complement(23415..25517)
                     /db_xref="GeneID:41542367"
                     /locus_tag="SAVERM_RS27240"
                     /old_locus_tag="SAV_5277"
                     /old_locus_tag="SAVERM_5277"
     CDS             complement(23415..25517)
                     /codon_start=1
                     /db_xref="GeneID:41542367"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325535.1"
                     /locus_tag="SAVERM_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5277"
                     /old_locus_tag="SAVERM_5277"
                     /product="biotin carboxylase N-terminal domain-containing
                     protein"
                     /protein_id="WP_010986681.1"
                     /sec_met_domain="ATP-grasp (E-value: 9.4e-06, bitscore:
                     24.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 5.5e-08,
                     bitscore: 31.4, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDTVLVANRGEIAVRVIRTLRALGVRSVAVFSDADADARHVREA
                     DTAVRIGPPPAAESYLSVERLLEAAARTGAQAVHPGYGFLAENAGFARACADAGLVFIG
                     PPADAISLMGDKIRAKETVQAVGVPVVPGSSGSGLTDAQLVDAAREIGMPVLLKPSAGG
                     GGKGMRLVRDERLLADEIAAARREARASFGDDTLLVERWVDRPRHIEIQVLADGHGNVV
                     HLGERECSLQRRHQKVIEEAPSVLLDEATRAAMGEAAVQAARSCGYEGAGTVEFIVPGG
                     DPSSYYFMEMNTRLQVEHPVTELVTGLDLVEWQLRVAAGERLPYGQRDIELTGHAVEAR
                     ICAEDPARGFLPSGGTVLALHEPQSDVVRTDSGLSEGTEVGSLYDPMLSKVIAYGPDRP
                     TALRRLRAALAETVTLGVQTNAGFLRRLLAHPAVVAGDLDTGLVEREVDGLVAQAVPPE
                     VYAAAALLRHAALGPQASGTSDSSGSFGTSGSPGTSGASGSSGASAWVDPFSVPDGWRL
                     GGERAWTAHHMRPAGQDPVTVRVRATADGGVELLLDDGLPPLRGTLPVAVAARGGAASR
                     FAFRLDGVTHTFAALPDGTWLGRDGDSWHLRDHDPVAASLTGAAHSGVDSLTAPMPGTV
                     TVVKVAVGDEVAAGQSLLVVEAMKMEHVISAPHAGTVSELDVTPGTTVAMDQVLAVITP
                     AEEETA"
     gene            complement(25526..27157)
                     /db_xref="GeneID:41542368"
                     /locus_tag="SAVERM_RS27245"
                     /old_locus_tag="SAV_5278"
                     /old_locus_tag="SAVERM_5278"
     CDS             complement(25526..27157)
                     /codon_start=1
                     /db_xref="GeneID:41542368"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140616.1"
                     /locus_tag="SAVERM_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5278"
                     /old_locus_tag="SAVERM_5278"
                     /product="carboxyl transferase domain-containing protein"
                     /protein_id="WP_010986682.1"
                     /transl_table=11
                     /translation="MQEAPELTSAADPASEAWRANEAAHRTLGEELRAKLAAARLGGGE
                     RARARHTARGKLLPRDRVDTLLDPGSPFLELAPLAADGMYEGQAPAAGVVAGIGRVGGR
                     ECLVVANDATVKGGTYYPMTVKKHLRAQEVALENRLPCVYLVDSGGAFLPMQDEVFPDR
                     EHFGRIFYNQARMSGAGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRGQGTIFLGGPPLV
                     KAATGEVVTAEELGGGEVHARVSGVTDHLAEDDAHALRIVRNIVSTLPARGPLPWAVEP
                     SVEPKVDPYGLYGAVPVDSRTPYDVREVIARVVDGSRFAEFKAEFGQTLVTGFARIHGH
                     PVGIVANNGILFSESAQKGAHFIELCDQRGIPLVFLQNISGFMVGRQYEAGGIAKHGAK
                     MVTAVACTRVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPGAKISVMGGEQAASVLA
                     TVKRDQLEARGESWPVDDEEAFKDPIRAQYEQQGSAYYATARLWDDGVIDPLETRQVLG
                     LALTACANAPLPQKDYTAPGFGVFRM"
     gene            27255..27845
                     /db_xref="GeneID:41542369"
                     /locus_tag="SAVERM_RS27250"
                     /old_locus_tag="SAV_5279"
                     /old_locus_tag="SAVERM_5279"
     CDS             27255..27845
                     /codon_start=1
                     /db_xref="GeneID:41542369"
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007382216.1"
                     /locus_tag="SAVERM_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5279"
                     /old_locus_tag="SAVERM_5279"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_010986683.1"
                     /transl_table=11
                     /translation="MATRTDAPTRREQILKEAARLFAERGFHGVGVDEIGAAVGISGPG
                     LYRHFAGKDAMLAELLVGISGQLLTGGKRRAAEAEGDPEALLDSLIEGHIDFALDDRPL
                     ITLHDRELDRLRDSDRKLVRQLQRQYVELWVEVVRNVYPGLDEPAARSAVHSVFGLLNS
                     TPHLGRPGALPGRAGTAALLHRMARGAFGAAGA"
     misc_feature    27916..27929
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.01"
                     /tool="antismash"
     gene            27943..29100
                     /db_xref="GeneID:41542370"
                     /locus_tag="SAVERM_RS27255"
                     /old_locus_tag="SAV_5280"
                     /old_locus_tag="SAVERM_5280"
     CDS             27943..29100
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41542370"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969014.1"
                     /locus_tag="SAVERM_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_5280"
                     /old_locus_tag="SAVERM_5280"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_010986684.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.6e-29, bitscore:
                     101.0, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8.7e-27, bitscore:
                     92.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.9e-45, bitscore:
                     151.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRTVFNEDHEAFRETLRAFIEAEVVPVYDEWFAAGQAPRDFYYK
                     LAELGVFGIRVDEEHGGAGIDSYKFEAVLYEETARAGISFGGSGVHVLLGLPYIKLLAT
                     DEQKKRFLPKFVSGEEMWAIAMTEPGTGSDLAGMKTTAKLSDDGTHYVLNGAKTFITGG
                     VHADRMIVCARTSAPTKEDRRHGISLFVVDTKAEGYSVGRKLDKLGLKTSDTAELAFVD
                     VKVPVEDLLGEENKGFYYLGHNLASERWGIAFGAYAQAKAAVRFAKQYVQERVVFGQPV
                     AAFQNTKFELAACQAEVDAAEAVVDRATEALDAGELTPAEAASAKLFATEVAHRVIDRC
                     LQLHGGYGFMNEYPIARLYADNRVNRIYGGTSEIMKTIIAKDMGL"
ORIGIN
        1 cgccttgtac ttctcgcccg cgtcgaccag cttgctccag tcgcccgccc acagcttgcc
       61 gacctcttcc cggtcggtgg gcagaccggc cttctcgaag aggtccttgc ggtagcagat
      121 cgccatcggg ccgacgtcgg tgccgaggcc gaccgtcctg ccgtccttgg tcgtggcctg
      181 cgcccacttc cagtccagcc acttgctctt gtccacaccc gagaccttgg acatgtccac
      241 gagcttgtcc gcctgggtgg cgacgatctc ggcgatgttg ccgacctcga cggcctgcac
      301 gtccatcagg ccgctgttgg tggtgaggtg gttcaggagc gccgggtagt agttctcgtt
      361 ccgctccacg acgttgtcag tgatcttgat gtcggggtgg agcttctcgt actcggtgta
      421 gagcccggcc tccttgaagc cctgggtgcc gaacaggccc agcgtgaggg tggttttccc
      481 cttgccgtcc gacgacgagc cgtcggaagc gccgtcgccg ctgtcgtcgg cgcagccggc
      541 cagcaacccg gcgcccagcg acgcgaccgc cgccaggacc accgcccggc ggacgatggg
      601 ggtccccccg ctcgagcgaa gccgagaggg ggggagggtg aatgctcgca tggcgtcctc
      661 ctgttgccct gacgtgccga ccccccggcc aactgcatgg ttgggcccgt tagttgttcg
      721 ctgcggctcg ggcggggaac gtgcgggatg tgtatgtgtc aggtaccgtg ggagcgctcc
      781 cacaagtgat gtgttgaaga gtcgtcggtc cgggcggggg tgtcaaggga gcggacatgg
      841 cgagatgcgt tcagttatcg gcctgttaac taactccgcg aggtggcgcc aactcgctcc
      901 gggcgggcgg tattcaggcc cgtcggcggg tgccgatgag gccttttcgg ccggtgcggg
      961 gctcggggag ggccgcaccg gggccggtcg ccggcccgga tgggactgtt agattccagg
     1021 ccagtgtggg tcgacgggag gcggagccaa tggcaggcca cggagcgcgg ggccggagcg
     1081 gcgggcggcc gacccttgag gaggtcgccg cgcgcgccgg ggtgggccgc ggcacggtct
     1141 cccgggtgat caacgggtcc ccccgggtca gcgacgccac ccgcgcggcc gtcgaggcgg
     1201 ccgtcgcgga gctcggctat gtcccgaaca cggcggcccg tgccctcgcc gccaaccgca
     1261 cggacgcgat cgccctggtc gtccccgaac cggagacccg cttcttcgcg gagccgtact
     1321 tctccgacat gctcaagggc gtgggctccg cgctgtcgga gaccgagatg cagctgctgc
     1381 tgatcttcgc gggcagcgac cgggagcggc agcggctggc ccagtacctg gcggcgcacc
     1441 gggtggacgg tgtcctgctg gtctcggtgc acgcggacga cccgctgccc gacctccttg
     1501 cccagctgga gatcccggcg gtgatcagcg gccgcagatc cgcggaggag acgctgccct
     1561 cggtcgactc cgacaacttc ggcggcggcc gggtcgccgt ggaacacctg atcgaccagg
     1621 gccgccgcaa cgtcgtccat ctcgccggcc gcctcgacgt ctacggcgcc cagcgccgcg
     1681 tcgacggcta ccgcgaggcg ctgcgggacg cgggacgccc ggtcgacgag agcctgatcg
     1741 tcgccggtga cttcacggag gagggcggcc ggcgcgcgat gaccgaactg ctggcccgct
     1801 gcccggcgct ggacgcggtc ttcgcgggct ccgacgtgat ggcggccggc gcgcgccagg
     1861 tcctgcggga ggccggccgt cgtatcccgg acgacgtggc actggtcggg tacgacgact
     1921 cggccatcgc ccgccacatg gaccccccgc tcaccagcgt ccgccagccg atcgaggaga
     1981 tgggccgcgc gatgatcgac ctgctcctcg acgagatcgc ggaccggcgc ccggcggtgt
     2041 cccggggcct ggagcgacgt cagctggtgc tcccgtcgga gctggtgcgg cgggcgtctt
     2101 cgtagacccg gccccgcggt ggctggtgcc cctgcccgga cagccgctgg tcaggcccgt
     2161 acggtcaggc cctggtcggc acccctggtc aggcccgtac ggtgagctcc caccgaatct
     2221 cgccgtcctg ctcccggtcg gtcggtgaca gcccggccgc ggcggcgacg gacgcggagg
     2281 cgtgatggtc cgggtggaca tgggcgacga cgatgcgtac ggacccggac tgccgggtga
     2341 gccggtcgac caggccctgg gccgcctccg aggcgaagcc ccgcccctgc cacggggtgc
     2401 ccaccaccca ggcgatctcc gcgacctcgc ccgtgacggt cgcctgcacg gtccccacca
     2461 gacacgcgtc cgcacgccgc cgcagcaccc agttgaccca gcggacgccg gggtggggcg
     2521 agccggcggc caggcgtgcg tagcgtgcgc gcagggcggc cggggtgtcg ggcacaccgc
     2581 cgatgaaggc atgcagcgcc gggtcgccga ggacctgggc catctcctcg gcgtgctcga
     2641 cgcgcagggg gaggagatcg aggcgggcgg tgcggatgat cctggcggtc ccggtggtcc
     2701 cggtggtccc ggtggtcccg gtggtcccgg tggtcccgac ggacgcggcg gggccggggg
     2761 gctcgggggg ttcggcgggt tcggggtgcg cgggcatcgg gcgaagccta cggggcggcg
     2821 cgtcccgctc cgaagtgccc gccacggtag gggccttgtc ccggcacgcc gggcaacgtc
     2881 cgccacccgt cggcgggatg ccgggacacc tggatgcgtc gcaacgggtc ccggacccta
     2941 cgcgtggctc cagatcaggc cgcccttgtc cttggtgtcg tcgcctctga cggtgaccgc
     3001 gtagacggcg accggcgcgc cctcggggat gtcgccgctc ttccacgcgg tgcagtacgg
     3061 cgcggtccgc ccgcgggtgg aggcggtgcg gtcgatggtg ccgtcgcggt tgatgtcgag
     3121 ccgggcctcg atgccccacc cgtcggtcgt cgtgtcgcag gcccggacgg agtcgcccgg
     3181 ggtggcgccg tccgggtcgg cgttccacag ggcgtacccg ccctcggtgt tggcccgctg
     3241 cgcggcggcg gtggccgtgc cctgcgcgcc gaggagaagg gcggtggcgg cgaggacggt
     3301 ggtgacgaca cggcctctgg cggagcggag cacggagagt ccccctggtg cgggtgagca
     3361 cggtgagagt ggtgatggcg ctgggtggaa cgaatccatg ccccttgatc gtccgcccac
     3421 tgtcccgtgt tacaggtcac acgactgctt gcaggtcaca cgactggttg caggtcacac
     3481 gactgaggcc ccggtccgct ttcgcggacc ggggcctctt gcagggtgag tgacgggact
     3541 tgaacccgcg gcatcctgga ccacaaccag gtgctctacc agctgagcta cacccaccat
     3601 gaccggtggt tctccgtttg gtctctccga ccggccgaga aaaagtgtac agggtccgag
     3661 ggggtgctcg cgcccgcctt tcttcggggc cctcgaaggg ccccgtcggg gcggctactg
     3721 cgcgggcagc acgtgcttcg cggcgatcgt gcgggccgtc tccgagtcgg ggcccggctg
     3781 cggtacgaag atggcctcgc ggtagtagcg cagctccgcg atcgactcgc ggatgtccgc
     3841 cagcgcgcgg tggttgccgc tcttctcggg gctgttgaag tacgccctcg ggtaccagcg
     3901 gcgggccagc tccttcaccg agctgacgtc cacgatccgg tagtggaggt aggtctccag
     3961 cgccgacatg tcgcgggcga ggaagccgcg gtcggtgccg accgagtttc cgcacagcgg
     4021 agccttgccg ggttccttga cgtgctcccg tacatacgcg agcacctgcg cctcggcgtc
     4081 cgccagcgtc gtgccggccg ccagctcgtc gagcaggccc gaggcggtgt gcatggtgcg
     4141 caccacctcc ggcatcgtct ccagcgcggc gtccggcggg cggatcacga tgtccacccc
     4201 ctcgcccagt acgttcagct cggagtcggt gaccagtgcg gccacctcga tgagcgcgtc
     4261 gtcggacagc gagagaccgg tcatctcgca gtcgatccac accatgcgat cgttcatgtg
     4321 tcttacctta tggcccgccc cggctccgcg gaccgcccgt gcacctccgt gagcgcggcc
     4381 gcacccggcc cggcaccacg gaaacagggc gggcggggga ccgtggtacg acccacgatg
     4441 cctcgcccgc cctgctgtca cggcagtcct acggcgcgct ccgctgcccc ggcaggctgg
     4501 gccgcccggc cgcgtacagc tcggatccat gtgacccatg tgatccatgc gacccgtgag
     4561 acccatgaga tccgtgggac ccgtgtttgc ccggttccgt ggacagggac gcggccggac
     4621 ccagtgagct cgcggccgcc gtgcggcgcg tctgcatcgg gaccggggcc tcctgcggca
     4681 gcgccggtgg cggtcccacg acgctgtccg gatccacggg ccgttcaccc tgcggacggc
     4741 gggcccggta ggcggcccgg taggcggccg gcgaggagcc gagctggcgg cggaagtgcc
     4801 cgcgcagcgc caccggcgag cggaagccgc agcggcccgc gacctcgtcc accgagtagt
     4861 ccgacgtctc caggagccgc tgcgcctgga gcacccgctg ggtgatcagc cactgcaggg
     4921 gagcgctccc ggtgagcgag cggaaccggc ggtcgaacgt acgcctgctc atgtacgcgc
     4981 gggcggcgag cgtctccacg tcgaactgct cgtggaggtg ctccagggcc caggcgacga
     5041 cctcggcgag cgggtcggcg ccgatctcct cgggtaaaga ccgatcgagg tagcgctcct
     5101 gcccgccgct ccggcgcggg gggaccacga gcctgcgggc gagcgcgccc gccgcctcgt
     5161 ttccgtggtc cgtccgcacg atgtgcaggc acagatcgat tccggccgcc gtacccgccg
     5221 atgtcagtac gtctccgtcg tccacgaaca gctcacgtgg gtcgacatgg accgacgggt
     5281 agcgcttggc cagcgtcggt gcgtacatcc agtgggtcgt cgccggacgg ccgtcgagca
     5341 gcccggccgc ggccagcacg aaggcgccgg tgcacagccc gactatgcgg gcaccctcct
     5401 catgcgcccg gcgcagtgcg tcgagcgctt cctccggcgg tggcgaggtg atcgaccgcc
     5461 aggccggcac gacgaccgtg cccgcccggg agatcgcctc caggccatgt ggtgcggtga
     5521 gttcaagccc tcctgtggtc cgcagtgggc cttcctcacc ggcggccacc agcagccggt
     5581 aacgcggcac gccggcgtcc tgacggtcga tcccgaacac cgaaagcggt atggaactct
     5641 cgaagatggg gccgccgctg aacagcagca ccgcgacgat ctccttgcgg cgtcgcccgg
     5701 aaagtttccg ggccgcggca tccggcgcgg cagtggagtc gtggctcata ctgctaagcc
     5761 cccctcggtg gtcgcggctc ctcggttgtg tcgctcctgc acgtttcccc tcggtcctgc
     5821 acgagtcccc cgccgtaaga cagtcatgat cgaatctact gtgtcgtgtg gtgccggcgt
     5881 gaccagttca ccatccggca gattgtcgac atggcaactt ggcgtgaagc attcgatcac
     5941 gaagcgttgc actcgtgagc cgtgcaggga agtgcgcctt gtcccagtgg ccggtccccg
     6001 tagggtgcgc gggtccccgg agaccctttc ggcccaggtg gaacgggggg tgagggggtg
     6061 ttcgagccag gggtgcacgg tggtcagaag ttggctgaaa gtatgcgggc gcgtgcgcgg
     6121 aaaccggtca gtcgaccggc gtatttcccg ccgtgtggcg gccgcctctg tgcgcccccg
     6181 agccactctt cccgtgtgcc ccgcccgtcc cctgccaacc gctcctgccg tgccgccccc
     6241 ggtgcgggac gcgctgccgg gccgcctcgt ccgacagccg cgccgcccct cgctcggact
     6301 gccgcagcag catccggcag accccggtga cggccgcgag ccccagcgcc gtaccggccg
     6361 ccccggcgag cgaggtgccg taccagacga ggaccacggg caccagggcg cagctgaaga
     6421 ccgcccagcg gacgacatcg ctcgccgtgt ccgacggcgg tgcggccgaa gggcgcgccg
     6481 gggacggggg cgccccctgg gcgggagtcc ggcgcaggtc gtcgggggag gtgcgggagg
     6541 tgggggaggt gcgggatacg ggcatggcgt gctccctgtg gcggtggcac ggggttcaac
     6601 gcgtgttcga tcggtcggtc actgtggtgc ccggtggtac tcctggcggt acggccggcg
     6661 gtaccgccgg ccgcggggcg tacggctgtg cgacccctgt gcaaaccgcc tgtacggggc
     6721 agcaaccatt gcgttacggg caccccctca tgcatgctcc ctggaacccc gcgcagcgtg
     6781 tgcggggcct gggcagagga ggcgtgccgc cgtacccttg ggggtatggg gttgggaaga
     6841 tgattcccgg acacagctcc gccgcacact gtcgtcccac ccacgaggat ccaaacgccg
     6901 agacactcat ggccggtcac gaattcttcg aacctgcgga ccgcaagcgc cccgtcgccg
     6961 atcccacggc ggccgagccc ttggcggcgg aagagccacg ccattcctgc gaccccgcct
     7021 tcaagcacgg ggtcgtcgtc ggcttcgacg gctcgacgtc cagcgagcgc gccctcgcgt
     7081 acgcgatcgg catggcccat cgctccgggt cgggcctgat catcgtgcat gtcgccaacc
     7141 ggctgcccac cacggtgtgg gccggctgcg agccgccggt cttcgtcgat gtgccggacc
     7201 accggaccga ggtcctcggg ctcgaactcg cctgcgcgga gtatctggcc gaggtgccct
     7261 ggatcctggt cgagcgcggc ggcgacatct gtcacgaact cgaagaggtg gggcgggagt
     7321 acgaggcgga cgcgatcgtc gtcggctcca cgcacggcat cgtcggccgt ctcttcggct
     7381 cggtcgcggg gcggctggcg aagcgcgccc agcgcccggt catcgttatt ccgtaactcg
     7441 ccgtcgtccc aggtgagatg agacctggga gcggccgact cccttgtgca gatgcccgaa
     7501 tctactcaca cgtagaggtg tttgtgccct tgtgaagggc ataactcggt caccgcacca
     7561 tcgcacatgt acgaagggag cccgccgtgg acaatgacgt ctccgcggga agcaccacca
     7621 cggtcgtcgg ccgactcacc ctcgggatca ccctgttggc cttcgggctc gggtacgccg
     7681 acgtgatcga cggagtgacg gcggctgacg ccgtatcagt ggcccactac gtcggcggcg
     7741 tggcgctgtt cgtcgcgggc ctgttggccc tgcgcgaacg cgacgcggcc tccggtacgg
     7801 ccttctcggc gctcggcgcc ctgtggttca cctgggccgt caccgccggc agccggatgt
     7861 ccgacaacgc cgcgggcctc ttcctcctgc tgttcgccct ggtcgcactg agcctgacgc
     7921 tcggggcggc gggcggcgtc ctcgaccagg gcgcctacgg cctgttcgcc gtctcgctcc
     7981 tgctgctggc catcgcgcac ttcgcgggca acgacggtct cggcaggatc ggcggctggt
     8041 tcgcggtggc cgcgggcgcg gtcgcctggt acgcggcgac ggcggccctg gcccactggc
     8101 ccaccgccct cccccgacgc gctgccggcc ggggggtgac ggccgccggc tgacagccgc
     8161 gggccgggga tgggcgcccc ggcccctgtg ggaacgggtc cctgtgcgct tggtgacacg
     8221 cacagggacc cgttcgtact gctgtcggag gtgacgccta ctccaccgtc accgacttgg
     8281 cgaggttcct gggcttgtcg atgtcccggc ccagcgccaa cgccgtgtgg taggcgagga
     8341 gttgcagcgg gatgcccatc aggatcgggt ccagctcgtc ctcgttcttc gggacgacga
     8401 tcgtctggtc ggccttctcc tgctcctggt gcgccaccgc gaggatcttg ccgctgcggg
     8461 ccttgatctc ctccagggcg gcgcggttct tctcgaggag gtcgtcgtcg gggacgatgg
     8521 ccaccgtcgg cagcgcgggc tcgatgaggg ccagcgggcc gtgcttcagc tcggaggccg
     8581 ggtaggcctc ggcgtggatg tacgagacct ccttgagctt cagggaggcc tcacgggcca
     8641 ccggatagcc gcgcacacgg ccgatgaaga gcatcgagcg ggcctcggcg tactgcgcgg
     8701 ccagcttctt gatctcgtcc tcctggtcga ggatctcgga gatctgggcg ggcagcttgc
     8761 gcaggccctc gatgatccgc ttgccgtcgc ggaccgacag gtcacgggtg cggcccaggt
     8821 gcagcgcgag cagcgcgaag gcgaccgtgg tgttggtgaa gcacttggtg gagacgacac
     8881 agacctcggg tccggcgtgc acgtacatgc cgccgtccgc ctcgcgggcg atcgccgagc
     8941 cgacgacgtt caccacgccg aggacccgcg cgcccttgcg cttcagctcc tgcacggcgg
     9001 ccagcacgtc gtacgtctca ccggactgcg agaccgcgat gtacagggtg tcggggtcga
     9061 cgaccgcgtt gcggtagcgg aactcggagg ccggctcggc gtccgcgggg atgcgggcca
     9121 gctcttctat catctgggcg ccgatcatgc ccgcgtggta cgaggtgccg cagccgagga
     9181 tcttcacccg gcgcacggca cgcgcctcgc gggcgtccag gttcaggccg ccgaggtgca
     9241 cggtggagaa ccggtcgtcg atccggccgc gcagcacgcg gtccacggcg tcggcctgct
     9301 cgtggatctc cttgtgcatg tacgtgtcgt ggccgcccat gtcgtacgag gcggcctccc
     9361 actccacggt ggtcggctcg gccgtcgtcc gggtgccctc ggtggtgtac gtacggaagt
     9421 cgtcggcctt cagcgtcgcc atctcgccgt cgtcgagcgt gacgatctga cgggtgtggg
     9481 tgaccagcgc ggcgatgtcc gaggcgacga acatctcctt ctcgccgatg ccgaggacga
     9541 ccggggagcc gttgcgggcc accacgatgc ggtcggggaa gtcggcgtgc atgaccgcga
     9601 tgccgtacgt gccctcgatc acgcgcagcg cctcgcggac cttgtcctcc agcttctcct
     9661 gctgggagcg ggcgatcagg tgggtgagga cctcggtgtc ggtctcggag aggaactcga
     9721 cgccgtcggc ctcgagcttc ttccgcaggt cggaggcgtt gtcgatgatg ccgttgtgga
     9781 cgacggcgac ctggttgtcc tgcgacatgt gcgggtgcgc gttgaggtcg gacggggcgc
     9841 cgtgggtggc ccagcgggtg tgggctatac cggtggtgcc cttgaagcgc gcggggacct
     9901 tggcctccag gtcacggacc cggcccttgg ccttgaccat cttcaggccg gccgtcttcg
     9961 ggctggtgac gacgatgccc gcggagtcgt agccgcggta ctccaggcgc tggagtccct
    10021 cgaggagcag cggagtgacg tcacgcttcc cgatgtatcc gacaatcccg cacatacagg
    10081 tggtccccta gttgtagaca gtcgcaggcg atctagccgt agacgatgcg gcgcagctgc
    10141 ctgagcgtga gctccggcgg cgcgaccgcg cggtacttca ggtccgcctc gatccgttcg
    10201 aagatcgtcg cgttcaccag gccctgggcc tggagttcgc ggtggcggcg acggacgtat
    10261 tcctcggtcg tctcgtcgaa gtaggcgagc acgtcctgga tcacccgcag cgcctcgccc
    10321 cggttgaggg gcgtggaccg cgtcagatga tcaacaagtt cgtcgtgcac ccggtagatc
    10381 ttggggtact gaaggccgat tcgcaagaat cctgcccgat ttcgggcaag tggctgttga
    10441 aactcttatg gggccctgtt cgagcgctgt ccatcctgtg tcctgcgccc cgttgcctgt
    10501 gcggagcaac ttctgactcc atggacatcc cacgcatggg cgtaccggag aagctcgccg
    10561 agcgcatgag catggccgag cagcacgaat accttcgcgc caggttctcg cggcgcaaca
    10621 tgatcagagg cggcgccgtg accctgggtg ccgtcgccgg tggcgccttc gtcccggggg
    10681 cgaccgcgcg ggccgcggtt cccgcgcagc gggcggccgc ctcggccgag aaggtcgacg
    10741 gcgccctcgt cgcccccttc ggccgccacc tcgcctacgg caccgacccg cgcacggaga
    10801 tgacggtctc ctggcaggtc ccggtcgcgg tgaagaagcc gtacatacgg atcggcgccc
    10861 acccctggga cctctcccgc aagatcgagg ccgaggtccg cgccctccac accccggccg
    10921 gcgtcggcgc gagcggcgac cacacccagt actacctgca cgcccggctc acccacctgc
    10981 gcccgggcag gacgtactac tacggcgtcg gccacgacgg cttcgacccg gccgccccgc
    11041 acctcgtggg taccctcggc accttcacca ccgcgcccgc gcacagtgag ccgttcacct
    11101 tcacggcctt cggcgacgag ggcgtcggct accacggcct cgccaacgac gccctgctgc
    11161 tcggccagaa cccggccttc cacctgcacg ccggcgacat cgcgtacgcg gacccggccg
    11221 gcgcgggcaa gaccggcgac accggcttcg actcgcgtat ctgggaccag ttcctcgccc
    11281 agaccgagtc ggtcgccaag tccgtcccgt ggatggtgtc gtacggcaac cacgacatgg
    11341 aggcctggta ctcgcccaac ggctacggcg gcgaggaggc ccgctggcag ctgccggaga
    11401 acggcccgga caaggcgaac ctgcccggcg tctactcctt cgtgcacggc aacacggcgg
    11461 tcatctcgct ggacgccaac gacgtgtcct tcgagatccc cgccaacctc ggtatctccg
    11521 gcggcaccca gaccaagtgg ctggaggcgc ggctcaagaa gtaccgggcg gcgaaggaca
    11581 tcgacttcat cgtcgtgttc ttccaccact gcgcctactg cacctcgacc gcgcactcct
    11641 ccgagggcgg cgtgcgccag gagtgggtgc cgctgttcga gaagtacacc gtcgacctgg
    11701 tgatcaacgg ccacaaccac cagtacgagc gcacggacgt catcaagggc gacgaggtca
    11761 ccaagaagct gccgatcggc ggcaccgcgt accccgagac ggagggcgtc gtctacgtga
    11821 cggcgggcgc ggcgggccgc agcctgtacg cgttcaccgc cccggactcg tacgagggcc
    11881 acgagaacga cgtcgagtcc gtgtcggcgt tcgtcaacct caagggcggc aagcagaacg
    11941 agacggtcgc ctggtcgcgc gtgcgctacc tcgactactc gttcctgcgc gtcgacgtga
    12001 cgcccgccgc caagggccgc acggccacga tgagggtgcg cggcatcgcc gagagcggcg
    12061 tggagatcga ccacttcacg gtggcgcgcc gggtctgacc ggcgggagcg gcgcggtcct
    12121 cacctccgct cgaggaccgc ctgcttggct ggttcctgcg gcggtacgtc cgcagcgggc
    12181 gccgtcggac gcggcggccg cgcctgcacc cctgccccgt tcttctggat gacttccgcc
    12241 atgaggggga tggttccacc ggctctgcgg gagagtggtc tatacccatt ggggttcatc
    12301 cccagtgcgg cccatagccg ttggggccca tgcccgttgg ggtccatgga agggagcgca
    12361 tgtgagacag caccacagaa cgccccgtct tctcggcacg ctgctgctcg tggcggctgc
    12421 cggcttctcc gtcgccggct cggcgcccgc cgcggccgcg aagacggcga gcccgctcgg
    12481 ccaggtcgtt ccggcccccg cctcggtcga cccgggcgga tcgccgtacc gcatcacccg
    12541 ggacacccgc atccgtgtgg acgactcgcg ggaggtacga caggtcggcg agtacctcgc
    12601 gggcatcctg cggccctcca ccggttaccg gctgccggtc gcctcccagg gcggcggagg
    12661 catccggctc cggctgggcg aacgctcgct gggcgacgag ggataccgcc tcgacagcgg
    12721 caggaacggc gtcaccatca ccgccgccgc accggccggg ctcttccacg gcgtgcagac
    12781 cctgcgccag ctcctcccgg ccgcggtcga gaagaactcc gtacagcccg gaccctggct
    12841 cgtcgcgggc ggcaccatca aggacacccc gcgctacggc taccgcggcg cgatgctcga
    12901 cgtgtcccgg cacttcttcg acgtcggcca ggtcaagcgc tacatcgacg agttggcgct
    12961 gtacaaggtc aacaagctgc atctgcacct ctccgacgac cagggctggc gcatcgcgct
    13021 cgacgactgg ccgcggctca ccacctacgg cggatcgacg caggtgggcg gcggccgagg
    13081 cggcttctac acgaaggccc agtacacgga gatcgtgcgg tacgcggcct cccgccatct
    13141 ggaggtcgtc ccggagatcg acatgccggg ccacaccaac gcggccctcg cctcctacgc
    13201 tgagctgaac tgcgacggca ccgcgccgcc gctctacacc ggcaccgacg tcggcttcag
    13261 ctcgctgtgc gtgggcaagc cggtgacgta cgacttcgtg gacgacgtca tccgtgagct
    13321 ggccgcgctc acacccggcc gctatctcca catcggcggt gacgaggccc actccaccag
    13381 ccacgccgac tatgtggcct tcatggacaa ggtgcagccc gtcgtcgcca agtacggcaa
    13441 gacggtgatc ggctggcatc agctgaccgg ggcgaccccg gcgaagggcg cgctcgccca
    13501 gtactggggg ctcgacgaca ccagcgccgc ggagaaggcg caggtcgtga aggccgcgca
    13561 gaacgggacg gggctggtcc tctcgccggc cgaccggatc tacctcgaca tgaagtacac
    13621 cgcggacacc ccgctcgggc aggactgggc gggtctggtc gaggtgcggc gggcgtacga
    13681 ctgggatccg ggcacctacc tcgccggagc ccccggcgcg tcgatcaggg gcgtcgaggc
    13741 gccgctgtgg acggagacga tcgtcaccgg cgcggacatc gactacatgg tcttcccgcg
    13801 gctgcccggc gtcgccgaac tcggctggtc gcccgcgtcg acccacgact gggacacgta
    13861 caaggtgcgg ctcgcggcgc aggggccgcg gtgggaggcg cgggggatcc ggtactaccg
    13921 gtccccccag gttccctggc ccggtgcgta ggtgaggaag gcggggctca ggaggaccgt
    13981 ctcctgagcc ccacccggct tcagagtccc gcgatcgggt tcttcaggtt gccgaccagt
    14041 tgcagtgcgc cggacggatc cgccagatcc accatctgct tgttgtcgcg cagctggagc
    14101 cggttcaggc aggacagcgc gaactccggc gcgaacatgt cgtactgccg gaacttgtcg
    14161 gcgagttcgg gcgtcgactc ctggtactcg cgtacggact cggcgaccgt ccgccagaag
    14221 tcctcctcgc cgaggacgcc ctcgtcggcc aggtcggccg ccaggaagcg gaagaagcag
    14281 tcgaagacgt ccgtgaagat cgacaggagc ttcttgtcct cggggacctc gacgcggatc
    14341 cgctcgaccg cgggcggcag caccgcctgc gggtccagga cggcgatctc ctcggcgatg
    14401 tccttgtaga tcgcgcgctg tacggcgccg tccttgagga cgaggatgac gttctcgccg
    14461 tgcggcatgt acacgaggtc gtacgcgtag aagctgtgca gcagcggcgt gaagtaggcg
    14521 cgcagatagc ggcgcagcca ctccaccggc gacagccccg aacgctcgat cagcgcgccc
    14581 gcgaaggagg cgcccgcgtg gtcgacatgg acgagggagg ccatggtggc caggctctcg
    14641 ccctcctgga gcgcgggcac ggggctctcg cgccacaggg cggcgagcat cttgcggtac
    14701 ggggagtagc ggtcggtggc ggcctcgtac tccaggtggc gatagccgac ggccgcgcgc
    14761 tcgcggatga ccgacaggcc ggtggacttg agcaccgggt cgttgtcgac gagctgggcc
    14821 agccagtcgt tgatggccgg ggtcgcctcc atgtaggcgg ccgagagtcc gcgcatgaag
    14881 cccatgttga ggacggacag agccgtcttg acgtagtgct tctcgggggc ggacttgttg
    14941 aagaacgtcc ggatggactg ctgggccagg tactcgtcgt cgccctcgcc gaggcagacg
    15001 agacggcgct gggcgacctc ggcggcgaag gtgacggaga gcttgttcca ccactgccag
    15061 gggtggacgg ggatgaggag gtagtcgtcg gggtcgaggc cctggtcgcg caaggtggca
    15121 gcgaagcggt tcagtgtctg ctcgcccagt tcctcgcgca ggaacgactc gtactcgatc
    15181 cccacgcccg ccgtgaacgc ggcccgcgag cggtgcgcgg ccagccacac cagccgcacc
    15241 gggctcgcgg tctcgggggc gtacgagagg tactcgtgga ccccgaagcc gagccggccg
    15301 ttgttggcga cgaagcaggg gtggccctcg gtcatgccgg tctcgatggc ctggaagccc
    15361 gcttcggcga gctcggcgac ggggatctgc ggcttggtga gcttgaaaca ggtgcccgag
    15421 agggtggagg agatctcctc cagatagacg ggcagcacct cgtcgctcag gccgagcgac
    15481 ttcttcagct cgatgaagaa gtccagggcg gcaaccggga gttcggcgcc gtcccggtgg
    15541 cgggtgatcg actcggcgtc gacctgccag tggtcgaggg agcggaggcg ggcggtgaag
    15601 cggtagcggg tcaggccgtc gtcgctgcgg acgacgtacg cgccgtcacc ggcggcctcc
    15661 ggagtgagca gccgctcgtg ggcgaactcg gcgagcgcct tgcggacgag gaggcggttg
    15721 gcccgctccc agcgctcggg ggagaggtgg gccacggcgt cggactgggt catacggctg
    15781 ctcctcgcac cgctgctgcg aactgctcgc gtgtgcagaa actcagcagc gccttcttct
    15841 ccggcttctg gatctcgcgc tcgggcacga acccgacggc ttcgttcagg gcgtgcacgg
    15901 ccttgttgcc cacgtcgggt tcgacgacga cacgccgggt ggccgggtcg gcgaacaggt
    15961 gctccatcac cgcggtgatc acggcccggg tgaagccgtg cacgggcgtg tccgtcggcg
    16021 cgaccaggaa gtgcatgccg acatcgccgg gctcgggctc gtacaggccg accagctcga
    16081 cgtgcgccgg gtcgtacttc tccatcagga acacgggctc gtcgtccagc agtccgagga
    16141 acgcgtcgtg gtactcgctg gccgcgatgg ccatgtactc gcgctccacg tcgtgcagtc
    16201 tcgcctcctg catcatccag aaggcggact tggggtgggt cacccagccg tgcagcagct
    16261 cggcgtcccg cgtcgggtcg agcgggcgga cggtgaaggt gcctatgtca ggggtgctca
    16321 tacggcgaac tcctggaacg cgatcgtctt ctcgaccggg tagtactcgg tgccgagcag
    16381 ctcacggatg atgtacgcgt tgcggtacgc gcccatgccc aggtcggggc tggtgatgct
    16441 gtgcgtgtgc acgccggcgt tctggaggaa gacgccgcgg cccgtcgtgt cgatggcgta
    16501 gttgcgggcg atgtcgaagt tgccctgggc gtcgtagcgc agccggtcgc gtacgggctt
    16561 caggaactcc ggctcggcgt atcggtagcc ggtggccagg atcaggccct gggagcgcag
    16621 ttcgtactcc ttctcctgct cctcctggcg gagggtgagg gtgtacgtgc cgttctcgta
    16681 cgtcgccccg ttcagcgccg agttggtcag caggcgcgtg gggaccgggc cacccaggtt
    16741 cttctggtac agcaggtcga agatctcgtt gatgaggtcg ccgtcgatgc ccttgaacag
    16801 gcccttctgc tccgcggtga ggcggtagcg ggtcggctcc ggcagcgcgt ggaagtagtc
    16861 gatgtactcc ggggaggtca tctccagcgt gagcttggtg tattcgaggg ggaagaagcg
    16921 cggggagcgc gtcacccagt tcagccggta tccgtggacg tcgatctcgc tgagcaggtc
    16981 gtagtagatc tcggcggcgg actggccgct gccgaccagg gtgatcgact ccttggcctg
    17041 gagctcctgc ttgtgctgca tgtagcggga gttgtggatg tggtccccgc ccaggccctg
    17101 gacggcctcc gggaggtacg cgggcgtgcc cgtgccgagg accaggtggc gggcgcggta
    17161 gaggtcaccg gcctccgtgc ggaccacgta cacgtcgtcc tcgtacgtca cctcggtgac
    17221 cgtcgtgccg aagcggatgc tggagagctt cgaggcggcc cagcggcagt agtcgtcgta
    17281 ctcgacccgg agcggataga agttctcccg gatgtagaac gagtacagcc ggcccgattc
    17341 cttcaggtag ttcaggaagg agtacgggga ggtcgggtcg gcgagggtca ccaggtccga
    17401 catgaagggc gtctggaggt gcgcgccctc caggaacatc cccgagtgcc attcgaagtc
    17461 cggcttggac tccaggaaga cgccctccag ttcggcgatc ggctcggtga ggcaggcgag
    17521 gccgaggttg aaggggccga gaccgatccc tacgaagtcg tacgtcttgc ctgcggacgt
    17581 cttttccatg gcttcaggaa gcgcggtcaa gggattctcc caggtactgc tcggcgtggc
    17641 cggcgatcag atcgagcacg gcggtgatgt cgtccgccgt ggtctcgggg ttgagcaggg
    17701 tgaacttcag gtagtggcgg ccgccgacct tggtgcccgc gacgacggcg tcgccggagg
    17761 cgaagatggc cttgcgggcg tacaggttgg cgcgatcgat ctcggccggg tcggtgacgg
    17821 ccgccgggat gtagcggaag acgagggtgg acagggacgg ctccacgacc acgtcgaagc
    17881 gcgggtcggc ggcgagcagt ttccagccct cggccgccag gtcgcagacc tcgtcgaaga
    17941 gttggccgat gccgtcggcg cccatcacgc gcagcgtcat ccacagcttg agcgcgtcga
    18001 agcgacgagt ggtctggagg gacttgtcga cctggttggg gatgcgctcc tcgaccatgc
    18061 ggcgcgggtt gaggtactcc gcgtggtagg tggcgtggcg cagggtggag gcgtcccgga
    18121 ccagcacggc ggacgaactc accggctgga agaaggactt gtggtagtcg acggtgaccg
    18181 agtcggcgcg ctcgatgccg tcgatccggt cccggtgctt cagggaggtg agcagcccgc
    18241 agccgtaggc cgcgtcgacg tgcatccagg cgccgaactg ggcgcacagc tcggctatct
    18301 cgggcagcgg gtcgatggag ccgaagtcgg tggtgccggc ggtggcgacg acggccatgg
    18361 ggagcaggcc gtcgcgcttg cagcgatcca gctcgtgggc gagcgcgacc gtctgcatgc
    18421 gcttgtcgtg gtcgacgggg atcgagacga ccgagtccgc gctcaggccc agcagtttcg
    18481 ccgacttctt cacgctgaag tggctgacct cggaggcgaa gacacgcagt ctggcgaggt
    18541 cgtcggactt ggcctcctcg cgggcgagga gcagcgcctg gaggttggac tggctgccgc
    18601 cgctggtgaa cacgccgtcc gcggcggggc cgaggccgat gcgctcgttg gtccagtcga
    18661 tgagcttgcg ctcgatcagg gtgccgcccg ccgactggtc ccaggtgtcg agggaggagt
    18721 tgacggcgga gaggatcgcc tcgccgacga ccgcggggat gaccaccggg cagttgaggt
    18781 gcgcgaggta gcgcgggtgg tggaagtaga cggcgtcgcg gaggtagacc tcttccagct
    18841 cgtcgaggac cgcggtggtg tcgtgcagcg ggcggtcgag gtcgatccgc tcgatccggg
    18901 gggcgagggc gtcgaccgtg atgccggtga acgggcttgc tgtggtggcg agtttggccg
    18961 ccacccgctc tattccttcg gtcacggaac ggcggtaccg atccgcggtc gtgtcattga
    19021 gcaggtgcga gcgcatgtgg gggtcctccg aggggacagt ccgtgcggaa cagaggagag
    19081 gggcagggga gagggcgcag cgccccgaca tcaacttagg ctagcctaac ctaagttatt
    19141 gcgtgctaaa cctgcccctc gccgtgaccg ccgtcactcc tgttcgcgca actgctcctc
    19201 gctcaggccc tgtcgccagt agccgacgaa cgtcacctgc cgtcggtcga tcccgcgctc
    19261 gcgtacgaga tggcggcgca gctccttcac gcagccggac tcgcccgcga tccaggcgta
    19321 cgggcgctcg gcgggcggga acgcggcggc tcggacggcg tcgagggcca tgggggagcc
    19381 ctcgccccgc gtctcgcgct cgctgtgtac gagccaggtg atctcggcgt ccgcctcggt
    19441 cgtcaggtcc tggatgtctc cggcgtcgtg gacctccagc cagaccttgg cgcgggtgcc
    19501 cgccggcagc cactccagga tggccgaggc ggcggggacg gccgtctcgt cggcccagac
    19561 gaccaccagg tcggtgccct cgggcgggcg gaagcggatc gcccggttgt ccgcgaccgc
    19621 ggggccgagc agcaggaccc ggtcgccggc ggtggcgcgt gaggcccacc gggaggcggg
    19681 gcctgccggg gcggccgcgc cgggctccac gccgtgcagc acgaagtcga tgtcgatctc
    19741 gacggtgttg ccatgggcgt cctggcgcag ggcccggagg gtgtacgagc gcatcaccgc
    19801 ccgtacgtcg tcgggcagtt cgcgccagcc ctgccaccag ttgtcgccca gctcgatcgg
    19861 gacggccggc tcggtctgcc ccgggtgcgg caggaacagc gacaggctct ggtcgcggcc
    19921 gtcggaggcg aacgcgtgca ggtcggcgcc ggtgaaggtg acgcggagca gagacgggcc
    19981 gagccgcctc gtccgtacga cctggaggga gaagaaacgg aacggggcgg ccacagccgt
    20041 cgtcatgagt gctcctgagt catcgtcagg gggcggtgat ccggccggtg gggcccggcc
    20101 ggagcgtcac cggcgggggt gtcagctgac cttcttcgcc ttctcgatgg cctcggcgag
    20161 gtcctcgagc agcggggcgc acttgtcgta cgacaggatc ggctcggggt tgcgggcggt
    20221 gacctggccg gccttgacgg cgggcagctt cttccaggtc gccttggtga tgtcggcggg
    20281 ctggatggtc gaggagcggt tgtccatgat gatgacgtcg gccttgtact tgtcgacgtt
    20341 ctcccagctc aggttctcga accagccgcc gctcgccttc agcgcggagg cggagggctc
    20401 gacgaagttc acgccgaggg ccttgaagta ctccaggtcg atggagaggt tcgaggtcga
    20461 gacgtagaag atgtcctggc tcgcggaacc ggccagcacc ttgatgtccg ggttggcctt
    20521 ggtggccgcg cgcagtcggg cggcggcgtc ctcgaaacgc ttcttggcct tggtgatcgt
    20581 ggcggaggag gtgtcggcgc cgagcgactt cgccagcgcc agcatgcgct ggaggggctc
    20641 ggtcaactgg cggtcgtaga cggagatccc gacgctcggg gcgccgacgg cgaggacctt
    20701 cttcttggac tccgcgggca cgtaccagag cgagccggcg tcgtcgaaca tcgtggtgat
    20761 cagcaggtcg ggcgcgaggg ccgcgtactt ctcgatgttg aactggccgt actcgttgcc
    20821 gaggatcgtc accttgctga tgtcgaggtc gccggcctgg acgtcggcct tgccgtcctt
    20881 ggtcttcgtc gggccgaaga cgcccttgac gtcgacgccg tagtcgtaca gcgcggcggc
    20941 gacaccggtg aaggcgacga tgctcgacgg ggtcttgtcc gccttggcgg tctggccgcg
    21001 gtcgtccttg aaggaccagg ggccggactt ggcagccgcc gtcccgctgt ccgagccact
    21061 gtctttcgcc ttgtcgtccc cgcaggcggc gagcgcggca ccgaggccga aggcgccgcc
    21121 tgccgcgagg atgccgcgac gggtgagatg ggtggcacgg gcgttggaca tgagtgtgac
    21181 tgctttcgaa cggggcggag cgtccgccgg acaagttcga aggtaggtta gcctaacctc
    21241 actgtttgtc cagagggcgg gcgccccgcg gccgcacctg tgagcagccc gtgcgcgacg
    21301 ggactcagcc cacgagcccc aactcccttg cgatcagcat ccgctgcacc tcgctggtgc
    21361 cctcgccgat ctccaggatc ttggagtcgc gccacatccg ggccaccggg tactcgttca
    21421 tgaagccgta gccgccgtgg atctgggtgg cctcgcgggc gttgtcgacg gcgaccgtgg
    21481 acgagtagag cttggcgatc gccgcctcct tcttgaaggg ctcgccggcg accaggcggg
    21541 acgcggcgtc acgccagccg acgcgggcca tgtgcgcctt catctccata tcggcgatct
    21601 tgaactggat ggcctggtac gccccgatgt tccgcccgaa cgcgtgccgt tccccggcgt
    21661 acttcaccga ctcgtccacg cagccctggg cgagcccggt ggccagggcc gagatggcga
    21721 tccgtccctc gtcgaggatc cgcaggaact gcgcgtaccc gcggccctgt tcgcccagca
    21781 ggttcgcggc cgggacgcgg acgtcggcga aggacagctc gcgggtgtcc gaggcgttcc
    21841 agccgacctt cgagtacggg gcggcgaccg tgaagccggg cgtgccggac gggacgatga
    21901 tcgaggagat cagcggtttc ccgtcgggct tccggccggt gaccgccgtg accgtcacca
    21961 accccgtgat gtcggtgccc gagttggtga tgaagcactt ggtgccgttg atcacccatt
    22021 cgttcgtcga ctcgtccagg cgggccgtcg tgcgcgtcgc gcccgcgtcc gagccgccgt
    22081 ccggctcggt gagaccgaag gcgccgagga tctcgccgga acacagccgg gggagccact
    22141 ccgccttctg cgcgtccgtc ccgaagaggt ggatcggcat cgcgcccagt gagaccccgg
    22201 cctccagggt gatggcgacg gaggagtcga cgcgggcgag ttcttcgagg gcgatgccga
    22261 gcgccagata gtcgccgccc atgccgccgt actcctccgg gaacggcagc ccgaacaggc
    22321 ccatgcggcc catctcgcgg acgatctcgt acgggaactc gtgccgctcg tagaagtcgc
    22381 cgatcttggg ggcgacgacg tcgtgcgcga actcctcgac cgtgcggcgg agttcttcca
    22441 gctcgggggt gagacggtgg tccatggcgg tcattgctcc ttgtgggaga gggcgcggac
    22501 ggtgcgggag gggctgggcc ggcccagtcg ctcggccatc cacacgctcg tggcggtgag
    22561 acgggcgagg tcgactccgg tgtcgatacc gaggccctga agcatccaca cgaggtcttc
    22621 ggtggcgagg tttccggtcg cggacctggc gtacgggcag ccgccgaggc cgcccgcgga
    22681 ggcgtcgacg gtcgtgacgc cgtgctggag cgcggcgagg gtgttggcga gcgcctggcc
    22741 gtaggtgtcg tggaagtgca cgccgatcgc acgggtcggc acgccctcct cggtcagttc
    22801 ggcgaggagg tcctggacat ggccgggggt ggcgaccccg atcgtgtcgc cgaggctcag
    22861 ctcgtcgcag cccatgtcca ggagggactt gcagacccgc acgacctggt ggatcgggac
    22921 cgcgccctcc caggggtcgc cgaagcacat ggagaggtaa ccgcgcaccc gcacgtccgc
    22981 ggccttcgca cgggtgacca ccggctcgaa catggccagc gcctcgtcca ccgtgcggtt
    23041 gaggttggcc ttcgcgaagg actcggtggc gctggcgaag acggcgacct gacgggcgcc
    23101 caggaccagt gcgcggtcca gcccgcgttc gttcggcacc aggaccggga gcgccacggg
    23161 gaggtcgctc acgagcggga acagctgctc cgcgtcggcg agttggggca cccacttcgg
    23221 gtggacgaag ctggtggcct cgatggtggt cagccccgcg tcggcgaggc ggcggatgaa
    23281 ctccgccttg acctccgtcg ggaccgtccc cttctcgttc tggaggccgt cgcgcgcgcc
    23341 gacctcgtgg atgcggacgc gggcggggag gtcctgggcc ggtacgacca tggggaggcc
    23401 cgactcgggg gtgctcatgc cgtctcctcc tctgcggggg tgatgaccgc cagcacctga
    23461 tccatggcga cggtcgtgcc cggtgtgacg tccagctcgc tgacggtgcc ggcgtgcggg
    23521 gcggagatga cgtgctccat cttcatcgcc tcgaccacca gcaggctctg cccggcggcc
    23581 acttcgtccc cgacggcgac cttcacgacg gtcaccgtgc cgggcatggg ggcggtgagg
    23641 gagtcgacgc cggagtgggc ggcgccggtg agggacgccg cgaccgggtc gtggtcgcgc
    23701 aggtgccagg agtcgccgtc gcggcccagc caggtgccgt ccggcagggc ggcgaaggtg
    23761 tgggtgacgc cgtcgagccg gaaggcgaac cgggacgcgg cgcccccgcg ggcggccacc
    23821 gctacgggga gcgtgccccg caggggcggc agtccgtcgt cgagtagcag ctcgacgccg
    23881 ccgtccgccg tggcgcgcac gcggacggtc acgggatcct gccccgccgg ccgcatgtgg
    23941 tgagccgtcc aggcacgctc gccgcccaga cgccagccgt cgggcacgga gaacggatcg
    24001 acccaggcgg aggccccgga cgagccggag gcccctgagg tcccggggga cccggatgtc
    24061 ccgaaggacc cggaggaatc cgaggtccct gaagcctggg ggccgagggc ggcgtggcgc
    24121 agcagcgccg ccgccgcgta cacctccggc gggaccgcct gcgcgacgag cccgtccacc
    24181 tcccgctcca ccaggcccgt gtccaagtcc cccgccacga ccgccgggtg ggccagcagc
    24241 cgccgcagga acccggcgtt ggtctgcacg ccgagtgtga ccgtctccgc gagcgccgcc
    24301 cggagcctgc gcagcgcggt cgggcggtcg gggccgtacg cgatgacctt ggagagcatc
    24361 gggtcgtaca ggctgccgac ctcggtgccc tcggagaggc ccgagtcggt gcgcaccacg
    24421 tcgctctgtg gctcgtgcag cgcgagcacc gtccccccgg agggaaggaa gccgcgcgcg
    24481 gggtcctcgg cgcagatgcg ggcctcgacc gcgtgcccgg tgagttcgat gtcccgctgc
    24541 ccgtacggaa ggcgctcgcc cgcggccacc cggagctgcc actccaccag gtcgaggccg
    24601 gtgaccagct cggtgaccgg gtgctcgacc tgaaggcggg tgttcatctc catgaagtag
    24661 tacgaggagg ggtccccgcc ggggacgatg aactcgacgg tgcccgcgcc ctcgtagccg
    24721 caggagcggg ccgcctggac cgccgcctcg cccatcgcgg cgcgggtcgc ctcgtcgagg
    24781 agcacgctgg gcgcctcctc gatgaccttc tggtggcggc gctggagcga gcactcgcgc
    24841 tcgcccaggt gcaccacgtt gccgtggccg tccgccagga cctggatctc gatgtgccgg
    24901 gggcggtcca cccaacgctc cacgaggagc gtgtcgtcgc cgaaggaggc gcgggcctcg
    24961 cggcgggcgg cggcgatctc gtcggcgagc agcctctcgt cgcgcaccag ccgcatgccc
    25021 ttgccgccgc cgcccgcgct gggcttcagg agtacgggca tgccgatctc ccgtgccgcg
    25081 tcgaccagct gggcgtccgt caggccgctg cccgaggagc cggggaccac cgggacgccg
    25141 accgcctgca ccgtctcctt ggcgcggatc ttgtcgccca tcaaggagat cgcgtccgcg
    25201 ggcggcccga tgaacacgag ccccgcgtcg gcgcacgcac gcgcgaagcc ggcgttctcc
    25261 gcgaggaagc cgtaccccgg gtgcaccgcc tgcgcgccgg tccgggcggc cgcctccagc
    25321 agccgctcca cggacagata gctctcggcg gccggcggcg gaccgatccg tacggccgtg
    25381 tcggcctcgc ggacgtgccg tgcgtccgcg tcggcgtcgg agaagacggc caccgagcgc
    25441 acgcccagcg cgcgcagggt acggatgacg cggacggcga tctcaccccg gttggccaca
    25501 agaacggtgt cgaacattcc caccctcaca tccggaagac gccgaagccg ggcgctgtgt
    25561 agtccttttg gggaagcggc gcgttggcgc acgcggtcag ggcgaggccc agtacctgcc
    25621 gggtctccag cgggtcgatc acgccgtcgt cccagaggcg ggccgtcgcg tagtaggcgc
    25681 tgccctgctg ctcgtactgg gcgcggatcg ggtccttgaa ggcctcctcg tcgtcgacgg
    25741 gccaggactc gccgcgcgcc tccaactggt cgcgcttgac ggtcgcgagg accgacgcgg
    25801 cctgctcgcc gcccatcacg gagatcttgg cgccgggcca catccacagg aagcgcggcg
    25861 agtacgcccg gccgcacatc gagtagttgc ccgcgccgta cgacccgccg atcaccacgg
    25921 tcagcttcgg cacgcgggtg caggcgacgg ccgtgaccat cttggcgccg tgcttggcga
    25981 tgccccccgc ctcgtactgc cggccgacca tgaagcccga gatgttctgg aggaacacca
    26041 gcgggatgcc gcgctggtcg cacagctcga tgaagtgggc gcccttctgg gccgactcgg
    26101 agaacaggat gccgttgttg gcgacgatgc cgaccgggtg gccgtggatc cgcgcgaacc
    26161 cggtgaccag ggtctgcccg aactccgcct tgaactcggc gaagcgcgaa ccgtccacca
    26221 cgcgcgcgat gacctcacgg acgtcgtagg gggtgcggga gtcgaccggc accgcgccgt
    26281 acagcccgta cggatccacc ttcggctcga cggacggctc gaccgcccag ggcagcgggc
    26341 cccgcgccgg cagggtggag acgatgttcc gcacgatccg cagcgcgtgc gcgtcgtcct
    26401 ccgccagatg gtccgtcacg cccgacacgc gcgcgtggac ctcgccgccg cccagctcct
    26461 cggccgtcac cacctcgccg gtggccgcct tcaccagggg cgggccgccc aggaagatcg
    26521 tgccctggcc ccgcacgatc acggcctcgt cgctcatcgc gggcacatac gcgccgcccg
    26581 ccgtgcagga cccgaggacg gccgcgatct gggggatgcc ggcgcccgac atccgtgcct
    26641 ggttgtagaa gatccgcccg aagtgctcgc ggtccgggaa gacctcgtcc tgcatgggca
    26701 ggaaggcgcc tccggagtcg acgagataca cgcacgggag gcggttctcg agggccacct
    26761 cctgggcgcg caggtgcttc ttcacggtca tcgggtagta cgtgccgccc ttgacggtgg
    26821 cgtcattggc gacgaccagg cactcgcggc cgccgacccg gccgatcccg gcgaccaccc
    26881 ccgcggccgg ggcctgcccc tcgtacatcc cgtcggccgc cagcggggcc agctccagga
    26941 acggtgatcc ggggtccagc agcgtgtcca cgcggtcccg gggcagcagc ttgccgcgcg
    27001 cggtgtgccg cgcccgtgcc cgctcgccgc cgcccagccg ggccgccgcc agcttggcgc
    27061 gcagctcctc gcccagcgtg cggtgcgccg cctcgttggc ccgccaggcc tccgacgcgg
    27121 ggtctgccgc gctcgtcagc tccggtgcct cttgcatcct gcggtcccct cacccagtgg
    27181 tccaccagtt aatgagcgtt aacgcatttc cttcaggtta acgaccgcta acctccctgt
    27241 ctagaattgc ttccatggcc acgagaaccg acgcccccac ccgccgcgag cagatcctca
    27301 aggaggctgc ccggctcttc gccgagcgcg gcttccacgg tgtgggggtc gacgagatag
    27361 gtgccgcggt cggcatcagc ggccccggtc tgtaccggca cttcgcgggc aaggacgcga
    27421 tgctcgccga gctgctcgtg gggatcagcg ggcagctgct gacgggcggc aagcgccggg
    27481 cggccgaggc ggagggcgac cccgaggcgc tcctcgactc gctcatcgag gggcacatcg
    27541 acttcgcgct cgacgaccgc cccctgatca ccctgcacga ccgtgagctg gaccgcctcc
    27601 gggacagtga ccgcaagctc gtgcggcagc tccagcgcca gtacgtcgag ctgtgggtgg
    27661 aggtggtgcg caacgtgtac ccgggcctcg acgaacccgc cgcccgttcc gccgtgcact
    27721 ccgtcttcgg cctgctgaac tccacgccac acctggggcg tccgggcgcg cttccggggc
    27781 gcgcggggac cgccgcactc cttcaccgta tggcgcgagg tgccttcggg gccgccgggg
    27841 cgtgacgagc gtctcggggt ggttgccctg gacgactgtc gcaaccggtc ggtaacctat
    27901 gtctgagcaa gcgcttagac ataacccaag gtggaggtag cggtgcgccg tacggtgttc
    27961 aacgaggatc acgaggcgtt ccgggagacc ctgcgcgcct tcatcgaggc cgaggtcgtc
    28021 ccggtctacg acgaatggtt cgccgccggc caggcgccgc gcgacttcta ctacaagctc
    28081 gccgagctgg gcgtcttcgg catccgcgtg gacgaggagc acggcggcgc gggcatcgac
    28141 tcgtacaagt tcgaggccgt cctgtacgag gagaccgccc gcgcgggtat ctccttcggc
    28201 ggctccggtg tgcacgtgct gctcggcctg ccctacatca agctgctcgc caccgacgag
    28261 cagaagaagc gcttcctgcc gaagttcgtc tccggcgagg agatgtgggc catcgcgatg
    28321 accgagccgg gcaccggctc cgacctcgcg ggcatgaaga ccaccgcgaa gctctccgac
    28381 gacggcacgc actacgtgct caacggcgcc aagaccttca tcacgggtgg cgtgcacgcc
    28441 gaccgcatga tcgtctgcgc tcgcacctcc gcgcccacca aggaggaccg ccgccacggc
    28501 atctccctct tcgtggtgga caccaaggcc gagggctact cggtgggccg caagctcgac
    28561 aagctcggcc tgaagacctc ggacaccgcc gagctggcgt tcgtcgacgt gaaggtcccg
    28621 gtcgaggacc tcctcggcga ggagaacaag ggcttctact acctcggcca caacctcgcc
    28681 tccgagcgtt ggggcatcgc cttcggcgcg tacgcgcagg ccaaggccgc cgtccggttc
    28741 gccaagcagt acgtgcagga gcgggtcgtc ttcggccagc ccgtcgccgc cttccagaac
    28801 accaagttcg aactggccgc ctgccaggcc gaggtggacg cggccgaggc cgtcgtcgac
    28861 cgggccaccg aggccctgga cgccggtgag ctgacccccg ccgaggcggc cagcgccaag
    28921 ctgttcgcca ccgaggtcgc gcaccgtgtc atcgaccgct gcctccagct gcacggcggc
    28981 tacggcttca tgaacgagta cccgatagcc cgcctctacg cggacaaccg cgtcaaccgc
    29041 atctacggcg gcaccagcga gatcatgaag acgatcatcg ccaaggacat gggcctgtaa
    29101 gctccgcgaa aaaagttcaa ggtacaactg acctatgagt caggcacttg agtccctgct
    29161 cgatctactc gacctcgagc ggatcgagca ggacatcttc cgcggccagt cccggtccgc
    29221 cgtcgtcccg cgcgtcttcg gcgggcaggt cgcggcgcag gcactggtcg ccgcgggccg
    29281 cacggttccc gaggaccggc tcgcccactc cctgcacgcg tacttcctgc gtgcggggga
    29341 cccgggcgcg ccgatcgtct acaccgtcga ccggatccgc gacggccgtt ccttcaccac
    29401 gcgccgtgtc gtcgccgtcc agcacgggca gccgatcttc cacctctccg cgtccttcca
    29461 gacgtacgag gagggcatgg agcaccaggc ggacatgccg cccgcacccg ctccggagac
    29521 gctgcccacg gcggcggaga tgctgccgcg gtacgcgcac ctgttcaccg agcccgtcgt
    29581 catcgaccgg ctcctggagg cccgcgaggc ggtcgacctg cgctacgtcg acgcaccgcc
    29641 cttcgggacc gtgggcgagc cccgcgaacc ccgctcccag gtgtggttcc gcacgaacgg
    29701 caagctcgtc gacgacccgc tgctgcacgt ctgtctcgcc acgtacgtct ccgacatgac
    29761 gctcctcgac tcc
//
