LOCUS       NC_003155              21008 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4831760
            Orig. end                         :: 4852768
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="27"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21008
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11008](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11008
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            396..2039
                     /db_xref="GeneID:41540979"
                     /locus_tag="SAVERM_RS20190"
                     /old_locus_tag="SAV_3912"
                     /old_locus_tag="SAVERM_3912"
     CDS             396..2039
                     /codon_start=1
                     /db_xref="GeneID:41540979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825715.1"
                     /locus_tag="SAVERM_RS20190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3912"
                     /old_locus_tag="SAVERM_3912"
                     /product="DNA repair helicase XPB"
                     /protein_id="WP_010985343.1"
                     /transl_table=11
                     /translation="MNGPLIVQSDKTLLLEVDHEQANECRRAIAPFAELERAPEHIHTY
                     RVTPLGLWNARAAGHDAEQVVDALVQYSRYPVPHALLVDIAETMDRYGRLTLSKHPAHG
                     LVLTTTDRPVLEEILRSKRVAPLVGARLDPDTVAVHPSERGQIKQTLLKLGWPAEDLAG
                     YVDGEAHPIELAEDGWALRPYQKQAVENFWHGGSGVVVLPCGAGKTLVGAGSMAQAKAT
                     TLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTRRKGVYP
                     HLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIG
                     PKRFDAPWKEIEAQGYIAPADCVEVRVNLTETERLAYATAETEEKYRFCATTATKRKVT
                     EALVRKFAGQQILVIGQYIDQLDELGEHLNAPVIKGETSNAQREKLFDAFREGEISVLV
                     VSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHQAHFYSVVARDTID
                     QDFAAHRQRFLAEQGYAYRIMDADELLTES"
     gene            complement(1997..3025)
                     /db_xref="GeneID:41540980"
                     /locus_tag="SAVERM_RS20195"
                     /old_locus_tag="SAV_3913"
                     /old_locus_tag="SAVERM_3913"
     CDS             complement(1997..3025)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645115.1"
                     /locus_tag="SAVERM_RS20195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3913"
                     /old_locus_tag="SAVERM_3913"
                     /product="glycosyltransferase 87 family protein"
                     /protein_id="WP_078234476.1"
                     /transl_table=11
                     /translation="MADALVYRAAGAAVLSGADLYGFTVTEWGLPATYPPFAALLFVPT
                     TWLAPGALKVAFVAGNVALLAALVRLSGRLAGRPAPLPAVCAATALALWLEPVFQTVLF
                     GQINLALACLVLWDLTRPGARCRGAALGIAAGVKLTPAVFIVYLLLRGRRREAATAAAA
                     FAGTVLLGALLLPAASVDFWTRRIFETGRVGKAWIVDNQSLQGLVARVLGEPSPGLAWA
                     LPTAVVAGAGLWLARRATSERRGILLAAFTALLVSPISWSHHWVWCLPLIAVLYAEGHP
                     RQAAATAAVFTARTLWLLPHQGDLDLQLSWWQQPPASPYPLLALLVLVQLSVRSSSASM
                     IR"
     gene            complement(3578..3772)
                     /db_xref="GeneID:41540981"
                     /locus_tag="SAVERM_RS20200"
                     /old_locus_tag="SAV_3914"
                     /old_locus_tag="SAVERM_3914"
     CDS             complement(3578..3772)
                     /codon_start=1
                     /db_xref="GeneID:41540981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673405.1"
                     /locus_tag="SAVERM_RS20200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3914"
                     /old_locus_tag="SAVERM_3914"
                     /product="hypothetical protein"
                     /protein_id="WP_037644680.1"
                     /transl_table=11
                     /translation="MSAATFSPGPARHSPASGATALRADVHHRHLLGDALRAVKVFARA
                     AMDVVLLGEYGEEAGVHRR"
     gene            4140..6188
                     /db_xref="GeneID:41540982"
                     /locus_tag="SAVERM_RS20205"
                     /old_locus_tag="SAV_3915"
                     /old_locus_tag="SAVERM_3915"
     CDS             4140..6188
                     /codon_start=1
                     /db_xref="GeneID:41540982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673406.1"
                     /locus_tag="SAVERM_RS20205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3915"
                     /old_locus_tag="SAVERM_3915"
                     /product="ATP-binding domain-containing protein"
                     /protein_id="WP_010985346.1"
                     /transl_table=11
                     /translation="MSSLSESPADPLSRERAHLAGSRAALRAMREDVENLDIRDVTANW
                     VNAEVLARQIDDRIKALADLSHTPLFFGRLDYLHAPGADRAEGAEGERFYIGRRHVHDA
                     EGDPMVIDWRAPVSQPFYRASKKDPLDVGLRRRFGYTAGDLTAYEDEHLSDPAEAATTS
                     KLLQQEIERPRVGPMRDIVATIQPEQDEIVRSGLSGSVCVQGGPGTGKTAVGLHRVAYL
                     LYAHRERLARTGTLVIGPNRSFLHYIEQVLPALGELEVKQATVDDLVAHVEIRGTDDAA
                     AAVIKGDARMAEVLRRAVRSHVTLPTEPVVVVRGSRRWRVPAYELEQIVRELMDRDIRY
                     GAAREALPQRIAHAVLVQMERSGEAPDDRVQDAVARNAAVKAAVKAIWPPVDPAKLVLR
                     LLTDADFLAVHADGVLEEDERKEILWARPVRSTKTAKWSAADAVLIDEATDLVQRTHSL
                     GHVVLDEAQDLSPMQYRAVGRRCTTGSATVLGDLAQGTTPWATRSWDEALAHLGKGDAV
                     IEELTAGFRVPTDVITYASRLLPHIAPGLTPVASVRENPGFFEVRTTATDAAVIDACAE
                     LLRNEGSIGLIAADARVPALAEALTAAGIGHLGPGEETTHDTRLTLVPASLAKGLEYDY
                     VVLDEPRAVVDGEPDERTGLRRLYVALTRAVSGLIVTHTAPLPSQLG"
     gene            complement(6301..7530)
                     /db_xref="GeneID:41540983"
                     /locus_tag="SAVERM_RS20210"
                     /old_locus_tag="SAV_3916"
                     /old_locus_tag="SAVERM_3916"
     CDS             complement(6301..7530)
                     /codon_start=1
                     /db_xref="GeneID:41540983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002696.1"
                     /locus_tag="SAVERM_RS20210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3916"
                     /old_locus_tag="SAVERM_3916"
                     /product="hypothetical protein"
                     /protein_id="WP_010985347.1"
                     /transl_table=11
                     /translation="MPSIRRRGVTAATAVIAAVLVTATACDSEKTDDAKASPSSSAQAD
                     QKIDTGQDDGDTTIGGYKLPAGVPTDLTGEALRQWKNGGWKDYSNWASKAEDFANPYIE
                     NFWTPEKMAEAKANAPAVVDAGSASSGSSGTTKTYLPDGTVKKKSATRVAASYHHSAPP
                     VGKLFFSSPQGSMVCSAAVVTDPAHPGKSNLVWTAGHCVHAGKGGGWYRNIAFVPSYNN
                     DARLNIQQASQNARSKSVSPYGIWWSDWATTSGAWIKGGAHQATTAYAYDYAVLHVKPE
                     KGGKSLQEQIGSALPVWFNAPSAKKIKTMKARGYPAESPYDGSKMYDCRGATKRLVLGY
                     RYPSDYPAQYMLGCTLNGGASGGPWFLAHNGRTYLVSNNSLSDRRTFVSGPRLGKNAKQ
                     VYLATSNKFK"
     gene            complement(7718..8416)
                     /db_xref="GeneID:41540984"
                     /locus_tag="SAVERM_RS20215"
                     /old_locus_tag="SAV_3917"
                     /old_locus_tag="SAVERM_3917"
     CDS             complement(7718..8416)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0055070 - copper ion homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967308.1"
                     /locus_tag="SAVERM_RS20215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3917"
                     /old_locus_tag="SAVERM_3917"
                     /product="copper homeostasis protein CutC"
                     /protein_id="WP_010985348.1"
                     /transl_table=11
                     /translation="MSTRAVLEVIALDAEDAVAAQAGGADRLELVADMSADGLTPPVET
                     FARIRAAVDIALRVMLRPADGFAAGDADRFAALVRAAGELRAAGADEFVFGFLGEDGGA
                     DLDAVERLVADLDGCHWTFHRAIDRAADRDALRKQLADLPGLDAYLTAGSADGVDDGLP
                     TLLAEAARSGEPGYTQRLLVGGGLRLDHVPRLRAAGIDAFHIGGAARPAGWSGPVSAQA
                     VQEWRTAVDA"
     misc_feature    8451..8466
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.4"
                     /tool="antismash"
     gene            complement(8605..9282)
                     /db_xref="GeneID:41540985"
                     /locus_tag="SAVERM_RS20220"
                     /old_locus_tag="SAV_3918"
                     /old_locus_tag="SAVERM_3918"
     CDS             complement(8605..9282)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057229.1"
                     /locus_tag="SAVERM_RS20220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3918"
                     /old_locus_tag="SAVERM_3918"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_010985349.1"
                     /transl_table=11
                     /translation="MTIADRYDDVRDPELPGRLLSTERDALIPLLRARPDGDFALRTAC
                     PGWTVRHVLAHCSAALTRVVESRFEEGVFSPEANERDIAERGDWTNTQVVDELERGMTE
                     AGAVIAKAGGALDMVALGEWVHAGDVREAFGEPGAYGGGGLAHALLLLAHVSREKRHVP
                     LHADLDDLDEPLLLGDAAGDRTPARYIGDAPTLVRLYAGRPLVGTRYELAGAGERELNI
                     FGR"
     misc_feature    complement(9317..9332)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            9330..9998
                     /db_xref="GeneID:41540986"
                     /locus_tag="SAVERM_RS20225"
                     /old_locus_tag="SAV_3919"
                     /old_locus_tag="SAVERM_3919"
     CDS             9330..9998
                     /codon_start=1
                     /db_xref="GeneID:41540986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072499.1"
                     /locus_tag="SAVERM_RS20225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3919"
                     /old_locus_tag="SAVERM_3919"
                     /product="hypothetical protein"
                     /protein_id="WP_037644679.1"
                     /transl_table=11
                     /translation="MVDHDALHRRWLGALVGARGGAAQPDPAPYGENLLRRWSEPQRRY
                     HTVEHLAAVLDRVDLLAEYADDPDVVRLAAWFHDAVYFPDRSENEERSARLAERALPEA
                     GVSGARTAEVARLVRLTVTHDPADDDRDGRVLCDADLAILAAPPKTYAAYAAAVREEYA
                     FVPDDSFRAGRAAVLRQLLDLPRLFRTPYGEREWEERARENLREELARLDDRGTSGAAQ
                     "
     gene            10001..11008
                     /db_xref="GeneID:41540987"
                     /locus_tag="SAVERM_RS20230"
                     /old_locus_tag="SAV_3920"
                     /old_locus_tag="SAVERM_3920"
     CDS             10001..11008
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540987"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="SAVERM_RS20230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3920"
                     /old_locus_tag="SAVERM_3920"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_159028996.1"
                     /sec_met_domain="phytoene_synt (E-value: 8.4e-24, bitscore:
                     83.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 8.5e-19,
                     bitscore: 66.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTSGAVRTPWQRALDSAGITTAKLRRDYTTAARRLLTRETAGY
                     AAVRALLPARLQPHLVAATAFSCATDDIVDAERPVAVRTAAFGRWREATRTALDTGRSR
                     FPVLRAYAHTAAVCEQSPGGVLEYLEGTAGDLEFTGFETEAAYQAYVDRLTLPFLMIST
                     GLQYPGGGDPAVRARWRPFADASQRLDFLTDLHTDLRAGRLCLPREDLTRHGVTVTDLA
                     GARDTYGVRRLIAETCARTRAALTEAHGVLEIATPDYQPLVRAGLSLWEHRLNEVERRG
                     AAVLRRPVSTGIREPLSILLRETRERGRERERGQRQGQGQGQGRASASDGVFSD"
     gene            complement(10998..11282)
                     /db_xref="GeneID:41540988"
                     /locus_tag="SAVERM_RS20235"
                     /old_locus_tag="SAV_3921"
                     /old_locus_tag="SAVERM_3921"
     CDS             complement(10998..11282)
                     /codon_start=1
                     /db_xref="GeneID:41540988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133863.1"
                     /locus_tag="SAVERM_RS20235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3921"
                     /old_locus_tag="SAVERM_3921"
                     /product="DUF4031 domain-containing protein"
                     /protein_id="WP_010985352.1"
                     /transl_table=11
                     /translation="MTLYIDPPTWPGHGHLWSHLVSDVSFDELRLFADGLGVPRRAFER
                     DHYDLPSHRYADAVRAGALEVSSREVVRLLHASGLRRPKHRGPAGPVSR"
     gene            complement(11279..11662)
                     /db_xref="GeneID:41540989"
                     /locus_tag="SAVERM_RS20240"
                     /old_locus_tag="SAV_3922"
                     /old_locus_tag="SAVERM_3922"
     CDS             complement(11279..11662)
                     /codon_start=1
                     /db_xref="GeneID:41540989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991123.1"
                     /locus_tag="SAVERM_RS20240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3922"
                     /old_locus_tag="SAVERM_3922"
                     /product="hypothetical protein"
                     /protein_id="WP_010985353.1"
                     /transl_table=11
                     /translation="MDPISPLEQALHAARALVLADLVAGQVAEADVVSLVEESVVERRW
                     WLEQWPDGADYVAGLVAQDVQDALLERYGRWPLCPVCGAGDPHALDVEPELGPDPHWVC
                     HKAGVKVASVGTLGSATGGKSSS"
     misc_feature    complement(11700..11714)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.17"
                     /tool="antismash"
     misc_feature    complement(11701..11716)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.91"
                     /tool="antismash"
     gene            11719..12645
                     /db_xref="GeneID:41540990"
                     /locus_tag="SAVERM_RS20245"
                     /old_locus_tag="SAV_3923"
                     /old_locus_tag="SAVERM_3923"
     CDS             11719..12645
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982606.1"
                     /locus_tag="SAVERM_RS20245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3923"
                     /old_locus_tag="SAVERM_3923"
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="WP_010985354.1"
                     /transl_table=11
                     /translation="MTHDVKEIFAGTTGGAPPAPAALAAKVRTLAPSMTRSMQRVAEAV
                     AGDPAGCAALTVTGLAELTGTSEATVVRTARVLGYPGYRDLRLALAGLAAQQQSGRAPA
                     VTADIAVDDPIADVVAKLAYDEQQTLADTAAALDTVQLGAAVTALAAARRVDVYGVGAS
                     GLVAQDLTQKLLRIGLIAHAHSDPHLAVTNAVQLRAKDVAIAITHSGSTGDVIEPLRVA
                     FERGATTVAVTGRPDGPVTQYADHILTTSTARESELRPAAMSSRTSQLLVVDCLFVGVA
                     QRTYETAAPALSASYEALAHRHRNTPR"
     gene            12762..13697
                     /db_xref="GeneID:41540991"
                     /gene="murQ"
                     /locus_tag="SAVERM_RS20250"
                     /old_locus_tag="SAV_3924"
                     /old_locus_tag="SAVERM_3924"
     CDS             12762..13697
                     /EC_number="4.2.1.126"
                     /GO_function="GO:0016835 - carbon-oxygen lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006040 - amino sugar metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009254 - peptidoglycan turnover [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540991"
                     /gene="murQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985355.1"
                     /locus_tag="SAVERM_RS20250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3924"
                     /old_locus_tag="SAVERM_3924"
                     /product="N-acetylmuramic acid 6-phosphate etherase"
                     /protein_id="WP_010985355.1"
                     /sec_met_domain="SIS_2 (E-value: 4.2e-07, bitscore: 28.9,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSMSHHRSLQAELETLTTEAFRPELAEIDQLPTLEIARLMNGED
                     ATVPAAVAARLPQIAAAIDAVADRMARGGRLVYAGAGTAGRLGVLDASECPPTFNTDPS
                     EVVGLIAGGPSAMVTSIEGAEDSKELAAGDLAGLGLTADDTVVGVSASGRTPYAIGAVE
                     YARARGALTVGLSCNADSALAAAADHGIEIVAGPELLTGSTRLKAGTAQKLVLNMLSTI
                     TMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGAADEEVERALAATDGEVKNAILT
                     ILGGVDGPTAARLLEESDGHLRAALAAAPR"
     gene            13714..15351
                     /db_xref="GeneID:41540992"
                     /locus_tag="SAVERM_RS20255"
                     /old_locus_tag="SAV_3925"
                     /old_locus_tag="SAVERM_3925"
     CDS             13714..15351
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010055966.1"
                     /locus_tag="SAVERM_RS20255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3925"
                     /old_locus_tag="SAVERM_3925"
                     /product="PTS transporter subunit EIIC"
                     /protein_id="WP_010985356.1"
                     /transl_table=11
                     /translation="MRTTPHSATAAAILPLVGGAANVTSVAHCMTRLRLGLADRSLVDE
                     ESLRALPAVLGVVDDDTYQIVLGPGTVAKVTPEFEKLLASETTEAPANALPVTAGAPTP
                     AAPTAAEGPATSETPVAAEPPARGSAPGTEAARLAARGAALKAAQRQRHATPVRLLLRR
                     IANIFVPLIPALIGCGVIAGVNGLLLNLGWLPSLTPALAAVASGFMALIAVFVGHHTAK
                     EFGGTPILGGAVAAVIVYAGVAKVTVFGTTLSPGQGGVLGALAAALLGTYVEKWCRTWV
                     PDTLDVLVTPTLTVLLTGLVTLYGLMYAAGAATSAIGTAATWLLSTTGVFAGLILGGLF
                     LPLVMLGLHQALIPLHTTLIEQQGYTVLLPVLAMAGAGQVGAALAVYVRLRHDHSLRTT
                     IRSALPAGLLGVGEPLIYGVSLPLGRPFLTACAGGAAGGAFVGLFSMLGDRIGSTAIGP
                     SGWALFPLLAGSGGLLPSAAIYAGGLLTGYAVGFGATYFFGSFGVVGGVCEAERTDIAA
                     PTGTAAPAMTTTPTDTAAPHDPEGNRTL"
     gene            15348..15935
                     /db_xref="GeneID:41540993"
                     /locus_tag="SAVERM_RS20260"
                     /old_locus_tag="SAV_3926"
                     /old_locus_tag="SAVERM_3926"
     CDS             15348..15935
                     /codon_start=1
                     /db_xref="GeneID:41540993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486314.1"
                     /locus_tag="SAVERM_RS20260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3926"
                     /old_locus_tag="SAVERM_3926"
                     /product="hypothetical protein"
                     /protein_id="WP_010985357.1"
                     /transl_table=11
                     /translation="MNHAQLTALGRALRLVGEHGEALSSQTPDARLHEVKADLKRALDL
                     LEDSVSAAAPSTRCAEHPNGPVDEDAPDLCLLCETRRRAARRSQVNDTYPHGRPPGADG
                     TAERAQSRYGVRGDRPQPQQRWLPELWNGQVWQLCGTPRRDKREAEQYLAAQRRGPRPA
                     MAYRLVHEFTDYEVLRIWGEPLKVDIEPMGNL"
     gene            16107..16463
                     /db_xref="GeneID:41540994"
                     /locus_tag="SAVERM_RS20265"
                     /old_locus_tag="SAV_3927"
                     /old_locus_tag="SAVERM_3927"
     CDS             16107..16463
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540994"
                     /inference="COORDINATES: protein motif:HMM:TIGR00377.1"
                     /locus_tag="SAVERM_RS20265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3927"
                     /old_locus_tag="SAVERM_3927"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_159045180.1"
                     /transl_table=11
                     /translation="MRRSEDRGKWAVVVLTGEVDCDLTPALREAVDSLTAEDHGLIVLD
                     LGQVSFMDSAGLGVVVYGMRRAGALGGRLRLAGPGEQVRELLRLTGLDAAVEVFGDVPA
                     ACAYGPTPKGLERI"
     gene            16490..18205
                     /db_xref="GeneID:41540995"
                     /locus_tag="SAVERM_RS20270"
                     /old_locus_tag="SAV_3928"
                     /old_locus_tag="SAVERM_3928"
     CDS             16490..18205
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540995"
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF018884.4"
                     /locus_tag="SAVERM_RS20270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3928"
                     /old_locus_tag="SAVERM_3928"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_159028995.1"
                     /transl_table=11
                     /translation="MESSPGGDEDFDANEALTSALFEAVGAGMYAVDGQGKVIACNPWA
                     ERLLGYAPGTLLGVDAHHTLHPMEGDENGLPAQRPVLADIVLGKRISGDRAVLLRADGT
                     PVQVWWSAAPLPEEMGYDKGAVVVFHDASARRARDGRRARRYAHSETMREQAEYDLSEI
                     TWLSELTLAMVSTLDADEALGRLVRQLVPRLADTALIDLTAGLTRRRAAATHHLPGVLP
                     SGPHDIGEPLPGHPAHDAALSRVFGGAGTQHLTAPLPAGPAYPGRDLFALVDAHEALVV
                     PLRLRASTFGALTLVRAPASPPFNEADRILAEEVARRAALGLDNTRLHAAQADIAATLQ
                     RALLTDLPTVPRLELAAHYQPAQRAAEVGGDWYDAFLLEDGDLAMAIGDVTGHDIQAAS
                     RMSELRNMLRALVVDRPEENPGQILRRLDTAQARLTLADSATAILTRLHPTADGTWDLA
                     WSVAGHPPPLLITADGTATYLTGPRAMLLGVRPTAERPTAHTRLPGGATLLLYTDGLVE
                     SRAQPFDVGMTRLRQYATTHRQLPLHRLCAQLAHDLGDTRDDITLIAARTPPTA"
     gene            complement(18300..19427)
                     /db_xref="GeneID:41540996"
                     /locus_tag="SAVERM_RS20275"
                     /old_locus_tag="SAV_3929"
                     /old_locus_tag="SAVERM_3929"
     CDS             complement(18300..19427)
                     /codon_start=1
                     /db_xref="GeneID:41540996"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673416.1"
                     /locus_tag="SAVERM_RS20275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3929"
                     /old_locus_tag="SAVERM_3929"
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="WP_010985360.1"
                     /transl_table=11
                     /translation="MTVTTDATDRAAQILSRPVTLNGLTVPNRIVMAPMTRQFSPGGIP
                     GEDVASYYARRAAAGVGLIVTEGTYVGHESAGQSDSIPRFHGEEQLAGWSKVADAVHAA
                     GGTIVPQLWHIGMVRGAGEPPFADAPPVGPSGIGTEGAEVTGKAMTQQDLDDVIEAFAK
                     AAADAERIGFDGVELHGAHGYLIDQFLWAGTNRRTDAYGGDPVARTKFAAEIVAAVRSA
                     VSPSFPVLFRYSQWKQQAYDARLAETPEELEAILAPLAAAGVDAFHASTRRYWQPEFDG
                     SDLNLAGWTKKITGKPAISVGSVGLNGEFLKAFQGEGSTVRGIDDLLDRLESGEFDLVA
                     IGRALLQDPEWAAKVLAGRFSELAAYDASSLKTLH"
     misc_feature    20087..20100
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.7"
                     /tool="antismash"
ORIGIN
        1 cctgaccgcc gcggtccgcg ccatccgcgc gggcgatctg gcctccactg ccccgcgcaa
       61 gccgaccgcc gacccggccg gcgcggacgg cggcctcccg cgcaccagct ccgccgagac
      121 cctcgccacc atgcaggccg ccgtcctcac cggcgaggcg gtctggatcg gctacgtcaa
      181 cgcggaaggc accgcgagcc agcgcgtgat cgccccgatc cgcgtggagg gcggcttcgt
      241 cactgcctac gaccacacgg cggacgaggt ccgcacgtac ccgctgcacc gggtcaccgg
      301 agtggcggaa ctggccgacg accaggcgtg atcatcctcc ggtacggcac actggaggtt
      361 tggccgtaca gagccatgca gaaagggtgc cgcgcgtgaa tggtccactc atcgtccaga
      421 gcgacaagac actcctgctc gaagtcgacc acgagcaggc gaacgagtgc cgacgggcca
      481 tcgcgccgtt cgccgagctg gagcgggcgc ccgagcacat ccacacctac cgggtgaccc
      541 cgctcgggct gtggaacgcg cgggccgccg ggcacgacgc cgagcaggtc gtggacgcgc
      601 tcgtgcagta cagccggtac cccgtgccgc atgccctgct cgtggacatc gccgagacga
      661 tggaccgcta cgggcggctg acgctctcca agcacccggc ccacgggctg gtgctcacga
      721 cgacggaccg gcccgtgctc gaggagatcc tccggtccaa gcgggtcgcc ccgctcgtcg
      781 gcgcccgcct cgaccccgac accgtcgccg tgcacccctc cgagcgcggg cagatcaagc
      841 agacgctgct gaagctgggc tggcccgccg aggacctcgc cggttacgtc gacggggagg
      901 cgcacccgat cgagctggcc gaggacggct gggcgctgcg gccgtaccag aagcaggccg
      961 tggagaactt ctggcacggc ggctccggcg tggtcgtgct gccctgtggc gcgggcaaga
     1021 cgctcgtcgg tgccgggtcc atggcgcagg ccaaggccac cacgctcatc ctcgtcacca
     1081 acaccgtctc cgcccgccag tggaagcacg agctggtgaa gcggacgagt ctcaccgagg
     1141 acgagatcgg tgagtacagc ggtacgaaga aggagatccg gccggtcacc atcgccacgt
     1201 accaggtgct gacgaccagg cggaagggcg tctacccgca cctggagctg ttcgactccc
     1261 gtgactgggg actcatcgtc tacgacgagg tgcatctgct gccggcgccc gtcttcaagt
     1321 tcaccgccga tctccaggcg cggcggcggc tggggctgac ggcgaccctc gtgcgggagg
     1381 acgggcgcga gtcggacgtc ttctcgctca tcgggcccaa gcggttcgac gctccgtgga
     1441 aggagatcga ggcgcagggg tacatcgcgc ccgccgactg cgtggaggtg cgggtcaatc
     1501 tgacggagac cgagcggctc gcgtacgcga ccgccgagac cgaggagaag tatcgcttct
     1561 gcgccaccac ggcgacgaag cggaaggtga cggaggcgct ggtccggaag ttcgccgggc
     1621 agcagatcct cgtcatcggc cagtacatcg accagctcga cgagctgggc gagcacctga
     1681 acgcgcccgt catcaagggc gagaccagca acgcgcagcg cgagaagctc ttcgacgcct
     1741 tccgggaggg cgagatcagc gtcctcgtcg tctccaaggt cgcgaacttc tccatcgacc
     1801 tgccggaggc gaccgtcgcc atccaggtgt cgggcacgtt cggctcgcgc caggaggagg
     1861 cgcagcggct gggccgcgtc ctgcggccca aggcggacgg ccaccaggcc cacttctact
     1921 cggtcgtcgc ccgcgacacc atcgaccagg acttcgccgc gcaccgccag cgcttcctgg
     1981 cggagcaggg ctacgcctac cggatcatgg acgcggacga gctcctgacg gagagctgaa
     2041 ccaggacgag cagcgcgagc agggggtagg gcgaggccgg cggctgctgc caccaggaga
     2101 gctggaggtc caggtcgccc tggtgcggga gcagccacag cgtgcgcgcc gtgaagaccg
     2161 cggcggtggc cgcggcctgg cgcgggtggc cttcggcgta cagcacggcg atcagcggca
     2221 ggcaccacac ccagtggtgc gaccagctga tcggggagac gagcagggcg gtgaaggcgg
     2281 cgagcaggat gccccggcgc tcgctggtgg cgcgccgggc gagccagagg ccggcgcccg
     2341 cgacgaccgc ggtgggcagc gcccaggcga ggccgggcga cggctctccc agcacgcggg
     2401 cgaccagccc ctgaagcgac tggttgtcga cgatccacgc cttgccgacc cggccggtct
     2461 cgaagatccg ccgggtccag aagtcgacgc tggcggcggg gagtaggagc gcgcccagca
     2521 gtacggtccc ggcgaaggcg gccgcggcgg tggccgcttc tcgtcgccgg cccctgagca
     2581 gcaggtacac gatgaagacg gcgggcgtca gtttcacccc ggccgcgatg ccgagcgcgg
     2641 ctcccctgca ccgggcgccg gggcgggtga ggtcccacag gaccaggcag gcgagggcga
     2701 ggttgatctg cccgaagagg acggtctgga agacgggttc gagccagagg gcgagggccg
     2761 tggcggcgca gacggcgggg agcggcgccg ggcggcccgc gagccggccg gagagccgga
     2821 cgagcgcggc cagcagggcc acgttcccgg cgacgaaggc caccttgagg gcgcccgggg
     2881 caagccaggt tgtcggtacg aacaggagcg ccgcgaaggg cggatacgtg gccggcaacc
     2941 cccactcggt gaccgtgaac ccgtacagat ccgcaccgct cagcacggcg gcgcccgcgg
     3001 cccggtagac cagggcgtcg gccatgggca cgccctggag gagacagagc gccccgaagg
     3061 agccgagcga acaggcgaga aggacgacgc tcgcggtggc ggggtgccgg agacgggcga
     3121 ggcgggacag ggcgggggcc ggcgcaggcg ccgtcgcacg ggccgttgcc acgaagcggc
     3181 gcgcacgtgc caccgccacg actgaccgca caggggccgc cgcaacggac cgtgtaccgg
     3241 ccgacgccac cgaccccgta cgggccgacg ccaccgaccc agtaccggcc gacgccaccg
     3301 accccgtacg ggccgacgcc accgacccag taccggccga tgtcaccgac cccgtaccgg
     3361 ccgacgccgc tgatcgtgcg cgggtcatcg ctactgatcg tgcgcgggcc atcgctacag
     3421 atcgcgtacg ggcgatcaca ttccgtcggg tcacggaaac ggaccctagt gcccgggcat
     3481 cccggcccgg ccgcggctca cagacccggc ggcgcccacg gcacccaccg gcggaaccgg
     3541 tgaagcccac ggcacccacc ggcggaaccg gcggagccta ccggcggtgg acgcccgctt
     3601 cttcgccgta ctcgccgagg agcaccacgt ccatcgccgc gcgggcgaag accttgacgg
     3661 cgcgcagggc gtcgccgagg aggtggcggt ggtggacgtc ggccctgagg gcggtggcgc
     3721 cggacgcggg gctgtgccgg gcagggcccg gagagaaggt cgctgcgctc atacatccat
     3781 catggatccg gccgcggcga atgcgtcggt cccaggacgt aacccgcacg gccccgccgt
     3841 acacctcggg tccgtccccc gtacgcccac ggagggaccc cgccccttag gggctccggc
     3901 ccggcccacc ccagggacac ccggttccct ggtccggcgc ccgtataaat ccgttggctc
     3961 ccgcatcctc ccgtcaccta caatctccgc tcctgcccgc ctcccttcac ggagagccgc
     4021 cgcccggacg gaaaccgggc ggcagaaccg ccaccaccca cacgcgaccg tcgaccgtcg
     4081 gccgacccgc cctcgcggca gccggccggc gcaccgccac gccccggagg catctccccg
     4141 tgtccagcct gtccgagagt cccgccgacc ccctctcccg cgagcgcgcc cacctcgccg
     4201 gctcccgtgc ggccctgcgt gcgatgcgcg aggacgtgga gaacctcgac atccgcgacg
     4261 tcaccgccaa ctgggtcaac gccgaagtcc tcgcccgcca gatcgacgac cgcatcaagg
     4321 cgctcgcgga cctcagccac acccccctct tcttcggccg cctcgactac ctgcacgccc
     4381 cgggcgccga ccgggcggag ggcgccgagg gcgagcgttt ctacatcggg cgccggcatg
     4441 tgcacgacgc cgagggcgac ccgatggtca tcgactggcg cgcgcccgtg tcgcagccgt
     4501 tctaccgggc ctcgaagaag gacccgctgg acgtcgggct gcgccgccgc ttcggctaca
     4561 cggcgggcga cctcactgcg tacgaggacg agcacctctc cgacccggcc gaggcggcca
     4621 ccaccagcaa gctgctccag caggagatcg agcgcccgcg cgtcggcccg atgcgcgaca
     4681 tcgtggcgac catccagccc gagcaggacg agatcgtacg gtcgggactg tccggctccg
     4741 tctgtgtcca gggcgggccc ggcaccggga agaccgccgt cggcctccac cgggtcgcgt
     4801 atctgctgta cgcccaccgt gagcgactcg cccgcaccgg caccctggtc atcggaccga
     4861 acaggtcgtt cctgcactac atcgagcaag tgctgcccgc cctgggcgag ttggaggtca
     4921 agcaggccac ggtcgacgac ctggtcgcac atgtcgagat ccgggggacc gacgacgcgg
     4981 ccgccgccgt catcaagggc gacgcccgga tggccgaggt gctgcggcgg gccgtccgct
     5041 cgcacgtcac cctgcccacc gagccggtcg tggtggtgcg cggctcccgt cgctggcgcg
     5101 tacccgccta cgaactcgag cagatcgtcc gggagttgat ggaccgtgac atccgctacg
     5161 gggccgcccg cgaggcgctg ccgcagcgga tcgcgcacgc cgtcctggtc cagatggagc
     5221 ggtccggcga ggcgcccgac gaccgggtgc aggacgccgt cgcccgcaac gccgccgtga
     5281 aggcggccgt caaggcgatc tggccgcccg tcgaccccgc caagctcgtc ctgcgtctgc
     5341 tcaccgacgc ggacttcctc gccgtgcacg cggacggagt cctcgaggag gacgagcgga
     5401 aggagatcct ctgggcgcgg cccgtacgca gcacgaagac cgccaagtgg tcggccgccg
     5461 atgccgtact gatcgacgag gcgaccgacc tcgtccagcg gacgcattcg ctcgggcacg
     5521 tcgtgctcga cgaggcacag gacctgtccc ccatgcagta ccgggccgtc ggccgtcgct
     5581 gtacgaccgg ttcggcgacc gtgctcggcg acctggcgca gggcacgacc ccgtgggcga
     5641 cgcggagctg ggacgaggcg ctggcgcacc tcggcaaggg cgacgcggtg atcgaggagc
     5701 tgacggccgg tttccgcgtg cccaccgatg tcatcacgta cgcgtcccgg ctgctgccgc
     5761 acatcgcgcc cggactgacg ccggtggcgt cggtgcgtga gaacccgggc ttcttcgagg
     5821 tgcgtacgac ggccaccgac gccgcggtga tcgacgcctg cgcggaactg ctccgcaacg
     5881 agggctcgat cggcctgatc gccgccgacg cacgtgtccc ggcgctggcc gaggcgctca
     5941 cggcggccgg gatcggccat ctcggtccgg gcgaggagac gacgcacgac acccggctca
     6001 ccctcgtacc ggcgtcgctg gccaagggcc tggagtacga ctacgtggtc ctggacgagc
     6061 cgcgggccgt cgtcgacggc gaaccggacg agcggacggg cctgcgccgc ctgtacgtgg
     6121 ccctcacccg tgcggtctcc ggcctgatcg tgacgcacac ggcgcccctg ccgagccagc
     6181 tcggctgacg cacacgaagc ccccggcgcc caccggcgcc gagggccccg tcgtcgtcac
     6241 gtcgtcgtca cgagatcgtc gcgccgggcc cgaaggccgg ccgccctacc tgaagccgcc
     6301 ctacttgaac ttgttgctgg tcgccagata gacctgcttg gcgttcttgc ccaggcgcgg
     6361 tccggacacg aaggtccggc ggtcgctcag cgagttgttg gacaccagat acgtacgccc
     6421 gttgtgcgcc aggaaccagg gtccgcccga cgccccgccg ttcaacgtgc agccgagcat
     6481 gtactgggcc gggtagtcgc tcgggtagcg gtagccgagc accaggcgct tggtggcgcc
     6541 gcggcagtcg tacatcttcg agccgtcgta cggcgactcg gcggggtagc cgcgcgcctt
     6601 catcgtcttg atcttcttcg ccgacggggc gttgaaccac accggcaggg ccgaaccgat
     6661 ctgctcctga agggacttgc cgcccttctc gggcttcacg tgcagcacgg cgtagtcgta
     6721 cgcgtaggcc gtcgtggcct ggtgggcgcc gcccttgatc cacgccccgg acgtggtcgc
     6781 ccagtcggac caccagatgc cgtacgggga gacgctcttg gagcgtgcgt tctgggaggc
     6841 ctgctggatg ttcagccggg cgtcgttgtt gtacgacggc acgaaggcga tgttgcggta
     6901 ccagccgccg cccttgcccg cgtgcacgca gtggccggcg gtccacacga ggttggactt
     6961 gccggggtgc gccgggtcgg tgaccacggc ggcggagcac accatggatc cctgggggct
     7021 gctgaagaac agcttgccga cgggcggcgc ggagtggtgg tagctcgccg ccacccgcgt
     7081 ggccgacttc ttcttcaccg tgccgtcggg caggtacgtc ttggtggtgc cgctggagcc
     7141 ggagcttgcg ctgcccgcgt cgacgaccgc gggtgcgttc gccttcgcct cggccatttt
     7201 ctccggggtc cagaagttct cgatgtacgg gttggcgaaa tcctccgcct tggaagccca
     7261 gttgctgtag tccttccagc cgccgttctt ccactgccgc aacgcttcac cggtgaggtc
     7321 ggtggggacg ccggccggga gcttgtagcc cccgatggtg gtgtccccgt cgtcctgacc
     7381 ggtgtcgatc ttctggtccg cctgggccga cgacgacggc gatgccttcg cgtcgtcggt
     7441 cttctcgctg tcgcaagccg ttgcggtgac cagcaccgcg gcgatcacgg cggttgcggc
     7501 cgtgacgccg cggcggcgta tggatggcat ggagctttgt ccccctgtga ctgaaacttg
     7561 tcatgccccg gcttggccgg gaaacgtccc tactatgcat gcagagggcg gttcagtgat
     7621 cgccggggga cactccgcac acaacaacta ccgggcggag atccctccgt gacatgacgt
     7681 cacgtcagga cccgaggccg ggtggggcca cgcgcggtca cgcgtcgacg gcggtccgcc
     7741 actcctgtac ggcctgtgcc gagaccggcc cggaccagcc ggccgggcgg gccgcgccgc
     7801 cgatgtggaa ggcgtcgatg ccggcggcgc gcagccgcgg gacgtggtcg agacgcaggc
     7861 cgccgccgac gaggagccgc tgggtgtagc cgggctcgcc gctgcgggcg gcctcggcga
     7921 gcagggtggg cagaccgtcg tccacgccgt cggccgaccc cgccgtgagg tacgcgtcga
     7981 gccccggcag atccgcgagc tgcttgcgca gggcgtcgcg gtcggcggcg cggtcgatcg
     8041 cgcggtggaa ggtccagtgg cagccgtcca ggtcggcgac cagccgctcc acggcgtcga
     8101 ggtcggcacc gccgtcctca ccgaggaacc cgaacacgaa ctcgtcggcg cccgcggccc
     8161 gcagctcccc ggcggcgcgg acgagcgcgg cgaaccggtc ggcgtccccc gccgcgaacc
     8221 cgtccgccgg ccgcagcatc acgcgcagcg cgatgtcgac ggcggcccgg atccgggcga
     8281 aggtctccac cggcggggtc agcccgtcgg cggacatgtc cgcgaccagt tcgaggcggt
     8341 ccgcgcctcc ggcctgggcg gcgaccgcgt cctcggcgtc gagggcgatc acctccagga
     8401 ctgcacgcgt gctcatagga ccccttccgt tggttctcct cggagcggct acaggtctag
     8461 tccaatctcc aagactacgc ccgtacgcgc cgcgcccgcg agaagatcac cgggagcggg
     8521 tcgaaccagc caccgcgaac gccggccacc gtgtccgccg gaagccgagt ccgccaaaag
     8581 ccgtgcccgc cggaagccgg ccggtcagcg tccgaagatg ttcagctccc gctcccccgc
     8641 ccccgcgagt tcgtaccgcg tgccgacgag cgggcggccc gcgtacagcc gtacgagggt
     8701 cggggcgtcg ccgatgtagc gcgccggggt ccggtccccg gccgcgtcgc ccagcagcag
     8761 cggctcgtcg aggtcgtcga ggtcggcgtg cagcgggacg tgccgcttct cgcggctgac
     8821 gtgggcgagc agcaggagcg cgtgcgccag cccgccgccc ccgtacgccc ccggctcccc
     8881 gaacgcctcg cgcacgtcgc ccgcgtgcac ccactcgccg agcgcgacca tgtcgagggc
     8941 gccgcccgcc ttggcgatca cggcccccgc ctcggtcatg ccgcgttcca gctcgtcgac
     9001 gacctgcgtg ttcgtccagt caccgcgctc ggcgatgtcc cgctcgttcg cctcgggact
     9061 gaacacgccc tcctcgaaac ggctctccac cacccgcgtc agcgcggccg aacagtgcgc
     9121 gagcacatgc cgcaccgtcc acccgggaca ggcggtccgc agcgcgaagt cgccgtcggg
     9181 acgggcccgc aggaggggaa tcagggcgtc gcgctcggtg ctcaggaggc ggccgggaag
     9241 ctcggggtct cgtacgtcgt cataccggtc tgcgatcgtc atgcctccca cgctaggggc
     9301 ccaccggcgc ggacgggaga atgaggcgca tggtcgatca cgacgcactg caccgccgct
     9361 ggctcggcgc cctggtcggg gcgcggggcg gcgccgccca acccgatccg gcgccgtacg
     9421 gcgagaacct gctgcgtcgc tggtcggagc cgcagcggcg ctaccacacg gtcgagcacc
     9481 tcgcggcggt cctcgatcgc gtcgacctgc tggcggagta cgcggacgac cccgacgtgg
     9541 tgcgtctggc cgcctggttc cacgacgcgg tctacttccc cgaccgctcg gagaacgagg
     9601 agcgttccgc ccgcctcgcc gagcgcgcgc tccccgaggc cggggtgtcc ggggcgagga
     9661 ccgcggaggt cgcccgcctc gtccgcctca ccgtcaccca cgacccggcc gacgacgacc
     9721 gcgacggccg ggtgctgtgc gatgccgacc tggcgatcct ggcggcaccg ccgaagacgt
     9781 acgcggcgta cgcggccgcg gtccgcgagg agtacgcgtt cgttccggac gactcgttcc
     9841 gggcgggccg cgcggcggta ctgcgccaac tcctggacct gcccaggctg ttcaggacgc
     9901 cgtacgggga gcgggagtgg gaggagcggg cccgggagaa cctgcgggag gaactggcgc
     9961 ggctcgacga ccgcgggacc agcggagcgg cacagtgaag gtgacgaaga cgtccggcgc
    10021 cgtgcggaca ccctggcagc gcgccctgga ctcggccggg atcacgacag ccaaactgcg
    10081 ccgcgactac accaccgccg cccggcggct cctgacccgc gagaccgccg gctacgcggc
    10141 cgtccgcgcc ctgctgcccg cccggttgca gccgcacctg gtggccgcca ccgcgttctc
    10201 ctgcgccacc gacgacatcg tggacgccga gcgccccgtc gccgtgcgca ccgctgcgtt
    10261 cgggcgatgg cgtgaggcga cccgcacggc gctggacacc ggccggtccc gcttcccggt
    10321 actgcgggcc tacgcccaca ccgcggccgt gtgcgagcag tccccgggcg gcgtcctgga
    10381 gtatctcgaa gggacggcgg gcgacctgga gttcaccggc ttcgagaccg aggcggccta
    10441 ccaggcgtac gtggaccgcc tcacgctgcc gttcctgatg atcagtacgg ggctccagta
    10501 cccggggggc ggcgacccgg ccgtccgcgc gcgctggcgc cccttcgccg acgccagcca
    10561 gcgcctggac ttcctgaccg atctgcacac cgacctgcgt gcggggcggc tgtgcctgcc
    10621 gcgcgaggac ctgacgcggc acggggtcac ggtgaccgat ctggcggggg cgcgggacac
    10681 gtacggggta cggcggctga tcgccgagac ctgcgccagg acgcgtgcgg cgctgaccga
    10741 ggcgcacggc gtcctggaga tcgccacccc cgactaccag cccctggtcc gggccggact
    10801 gtccctctgg gaacaccgtc tgaacgaggt ggagcgccgg ggtgcggccg tcctgcgccg
    10861 cccggtgtcg acgggaatcc gcgaaccgct ctcgatcctg ctgcgcgaga cgcgggagcg
    10921 ggggcgggaa cgggagcggg ggcagagaca gggacaggga cagggacagg gtcgcgcgtc
    10981 ggcctcggac ggggtattca gcgactgacc gggcccgcgg gaccccggtg cttcggcctg
    11041 cgcagcccgg acgcgtgcag cagtcgtacg acctcgcggc tgctgacctc cagcgccccc
    11101 gcccgcaccg cgtccgcgta ccggtgggag ggaaggtcgt agtggtcgcg ctcgaaggcc
    11161 cgccggggga cgcccagccc gtcggcgaac aggcgcagtt cgtcgaacga gacgtcgctg
    11221 accaggtggg accacaggtg tccgtgcccc ggccaggtgg gtggatcgat gtacagcgtc
    11281 acgaggacga cttcccgcct gtcgccgacc ccagcgtccc caccgacgcg accttcacgc
    11341 ccgccttgtg gcacacccag tgcgggtcgg ggccgagctc cggctcgacg tcgagcgcgt
    11401 gcgggtcgcc ggcgccgcac accgggcaca gcggccagcg gccgtaccgc tccagcagcg
    11461 cgtcctgcac gtcctgcgcg accagcccgg ccacgtagtc cgcgccgtcc ggccactgct
    11521 cgagccacca gcggcgctcc acgacggact cctcgacgag ggagacgacg tccgcctcgg
    11581 cgacctggcc cgcgaccaga tcggcgagca ccagggcgcg agccgcgtgc aacgcctgct
    11641 ccagggggct gatggggtcc atgcatccat tgtgcgcact cttgaccgta gctccgaaca
    11701 gaaaatatct ttcatggcgt gacccatgac gtgaaggaaa ttttcgcggg cacgaccggc
    11761 ggggcgccgc ccgcccccgc cgcgctcgcg gccaaggtgc gcacgctcgc gccgtcgatg
    11821 acccgctcca tgcagcgggt cgccgaagcc gtcgccggcg acccggccgg ctgcgccgcc
    11881 ctcaccgtca ccggcctcgc cgagctcacc ggcaccagcg aggccacggt ggtacgcacc
    11941 gcccgcgtcc tcggctaccc cggctaccgc gacctgcgcc tcgcgctcgc cggtctcgcc
    12001 gcccagcagc agtcgggccg cgcgcccgcc gtcacggcgg acatagcggt cgacgacccc
    12061 atcgcggacg tggtcgccaa gctcgcgtac gacgagcagc agaccctcgc cgacaccgcg
    12121 gccgcgctcg acaccgtcca gctcggcgcg gccgttaccg ccctcgcggc cgcccgccgc
    12181 gtcgacgtgt acggcgtggg ggcctccggt ctcgtcgccc aggacctcac gcagaagctg
    12241 ctgcgcatag gcctgatagc ccacgcgcac agcgatccgc acctcgccgt caccaacgcc
    12301 gtgcagttgc gcgccaagga cgtggcgatc gcgatcacgc actccggctc gaccggcgac
    12361 gtcatcgaac ccctccgggt cgccttcgag cgcggggcga cgacggtcgc ggtcaccggc
    12421 cgtccggacg ggcccgtcac gcagtacgcg gaccacatcc tgaccacgtc gacggcgcgc
    12481 gagagcgagc tgcgcccggc cgcgatgtcg tcccgcacca gtcaactgct cgtcgtggac
    12541 tgcctgttcg tgggagtggc gcagcggacg tacgagacgg cggcgccggc cctgtccgcc
    12601 tcgtacgagg cgctggcgca ccggcaccgc aacactccgc ggtagcgctc cgcggtagac
    12661 cggaaggact gaacgccgcg ggtcgcccat ggccggtcgc gcagttcccc gcgcccctga
    12721 ggggcgcgac accacaccgc acgtggaaag agccacccca gatgacatcc atgtcccacc
    12781 accgcagtct tcaggccgag ttggagacgc tgacgaccga ggcgttccgg cccgaactcg
    12841 ccgagatcga ccagttgccc accctggaga tcgcgcggct gatgaacggc gaggacgcga
    12901 ccgtccccgc cgcggtcgcc gcccgcctcc cgcagatcgc cgccgcgatc gacgccgtcg
    12961 ccgaccggat ggcccggggc ggccgcctgg tctacgcggg cgcgggcacg gccggccggc
    13021 tcggcgtgct ggacgcgtcc gagtgcccgc cgaccttcaa cacggacccg tccgaggtcg
    13081 tgggcctgat cgcgggcggc ccgagcgcca tggtgacgtc gatcgagggc gccgaggact
    13141 cgaaggagct ggcggccggg gacctggccg ggctcgggct gacggcggac gacacggtgg
    13201 tcggtgtctc cgcctccggc cgcacgccgt acgcgatcgg cgccgtcgag tacgcgcggg
    13261 cccggggcgc cctcaccgtc ggcctgtcct gcaacgcgga cagcgcgctc gcggcggccg
    13321 cggaccacgg catcgagatc gtggccggcc ccgagctgct caccggctcc acccggctga
    13381 aggcgggcac ggcccagaag ctcgtcctca acatgctgtc gacgatcacg atgatccgcc
    13441 tcggcaagac gtacgggaac ctgatggtcg acgtacgcgc ctcgaacgag aagctgcggg
    13501 cccgctcccg ccgcatcgtg gccctggcga cgggcgcggc ggacgaggag gtcgagcggg
    13561 ccctcgcggc cacggacggc gaggtgaaga acgcgatcct cacgatcctg ggcggggtcg
    13621 acggaccgac cgccgcccgc cttctggagg agagcgacgg ccatttgcgc gcggcgctcg
    13681 cggcggcgcc ccgctgagca gcacgctcgg caggtgcgta ccactcctca ctcagccacg
    13741 gccgccgcga tcctccccct ggtcggcggc gccgcgaacg tcacctccgt cgcccactgc
    13801 atgacccgcc tgcgcctggg cctggccgac cgctccctgg tggacgagga atccctcagg
    13861 gcgctgccgg ccgtgctggg ggtggtggac gacgacacgt accagatcgt cctcggcccg
    13921 ggaacggtcg cgaaggtgac cccggaattc gagaaactgc tggcatcgga aaccaccgag
    13981 gcaccggcga acgcgctgcc ggtgaccgcc ggggccccga cgcccgcagc accgacggcc
    14041 gccgagggac cggcgacctc cgagactccg gtagccgccg agccccccgc tcgcggtagc
    14101 gctcccggta ccgaggccgc ccggctcgcg gcgcgcggcg ccgccttgaa ggcggctcag
    14161 cggcagcgtc acgcgacccc cgtacgcctt ctcctgcgcc ggatcgccaa catcttcgtc
    14221 ccgctgatcc cggccctgat cggctgcggc gtcatcgcgg gcgtgaacgg cctgctcctg
    14281 aacctggggt ggctgccctc cctcaccccc gccctcgccg ccgtcgcctc cggcttcatg
    14341 gccctgatcg cggtcttcgt cggtcaccac acggcgaagg agttcggcgg caccccgatc
    14401 ctcggcggcg cggtggcggc ggtgatcgtg tacgcggggg tggcgaaggt gacggtgttc
    14461 ggtacgacgc tgtccccggg ccagggcggt gtcctcggcg cgctggcggc cgcgctcctg
    14521 ggaacgtacg tcgagaagtg gtgccgcacc tgggtcccgg acaccctgga cgtcctcgtc
    14581 acccccacgc tcacggtcct gctgaccggc ctggtgaccc tgtacggcct gatgtacgcg
    14641 gccggagcgg ccacgtcggc catcggcacg gcggcgacct ggctcctgtc cacgacgggc
    14701 gtcttcgccg gcctgatcct gggcggcctg ttcctccccc tggtgatgct gggcctgcac
    14761 caggccctca tccccctcca caccaccctc atcgaacagc agggctacac ggtcctcctc
    14821 cccgtgctgg cgatggcggg cgcgggccag gtcggcgcgg ccctcgcggt gtacgtccgg
    14881 ctgcgccacg accactccct gcgtacgacg atccggtcgg cgctcccggc gggcctgctc
    14941 ggcgtgggcg aacccctgat ctacggcgtc tcgctccccc tcggccgccc gttcctcacg
    15001 gcctgcgcgg gcggcgcggc gggcggcgcc ttcgtgggcc tcttctcgat gctgggcgac
    15061 cggatcggct cgacggcgat cggcccgtcg ggctgggccc tgtttccgct gctggcgggg
    15121 agcgggggcc tgctccccag cgccgcgatc tacgccggcg gcctgctgac ggggtacgcg
    15181 gtggggttcg gggcgacgta cttcttcggc tcgttcggcg ttgtcggtgg cgtgtgcgag
    15241 gctgaacgca ctgatatcgc cgcaccgacc ggcaccgccg caccggccat gaccaccacc
    15301 ccgaccgaca ccgccgcccc gcacgacccg gaagggaacc gcaccctgtg aaccacgcgc
    15361 aactgaccgc tctgggccgc gccctgcgac tcgtcgggga gcacggcgag gcactgagct
    15421 cacagacgcc cgacgcgcgc ctgcacgagg tcaaggccga cctgaagcgg gccctcgacc
    15481 tgctggagga cagcgtcagc gcggcggcgc ccagcacccg ctgcgccgag catccgaacg
    15541 gcccggtcga cgaggacgcg cccgacctgt gtctgctgtg cgagacgcgc cgccgcgccg
    15601 cccgccgctc ccaggtgaac gacacgtacc cgcacggcag gccgcccggc gcggacggca
    15661 ccgccgagcg cgcccagtcc cgctacgggg tgcgcggcga ccgcccccag ccccagcagc
    15721 gctggctccc ggagctgtgg aacggccagg tctggcagct gtgcggcacc ccgcgccggg
    15781 acaagcgcga ggcggagcag tacctcgcgg cgcagcgcag aggcccgcgc ccggcgatgg
    15841 cctaccgcct ggtgcacgag ttcaccgact acgaggtcct gcgcatctgg ggcgagcccc
    15901 tgaaggtgga catcgagccg atgggaaacc tgtagaagcg ccgctgggaa cccgtaggag
    15961 cgccgccggg aacccgtagg agcgccgccg ggaacccgta ggagcgccgc cgggcacccg
    16021 atgcctcctg gtgtgcccgg cccgggtgcg actatggggg gattccaggg tgaggaggaa
    16081 ccaccgtgtt ggttccgatg tccagcgtgc gacggtccga ggaccgcggg aaatgggcag
    16141 tggtggtcct caccggcgag gtggactgcg acctgacgcc ggcgctgcgt gaggcggtgg
    16201 actccttgac cgccgaggat cacggactga tcgtgctgga tctgggacag gtgtcgttca
    16261 tggactccgc gggcctcggc gtggtggtgt acgggatgcg gcgtgccggg gcactgggcg
    16321 gcaggctgcg gctggcgggc cccggcgagc aggtccgcga gctgctgagg ctgaccgggc
    16381 tggacgccgc cgtcgaggtg ttcggtgacg tcccggcggc gtgcgcgtac ggcccgacgc
    16441 ccaagggcct ggaaagaatc tgaggcccag gagggcaaaa atgggctgcg tggagagttc
    16501 cccgggcggg gacgaggact tcgacgcgaa cgaggcgttg acgtcggcgc tgttcgaagc
    16561 cgtgggcgcg ggcatgtacg ccgtggacgg gcagggaaag gtgatcgcct gcaacccgtg
    16621 ggcggagcgg ctgctgggct atgcgccggg cacgctgctc ggcgtcgacg cccaccacac
    16681 gctgcacccg atggaaggcg acgagaacgg tctgcctgcc cagcggccgg tcctggccga
    16741 catcgtgctc ggcaagcgga tcagcggcga ccgggccgtg ctcttgcgcg ccgatggcac
    16801 ccccgtgcag gtgtggtggt ccgcggctcc gctgccggag gagatgggat acgacaaggg
    16861 cgcggtggtc gtcttccacg acgcctccgc cagacgtgcg cgggacggac gccgcgcccg
    16921 gcgctacgcg cacagcgaga ccatgcgcga acaggccgag tacgacctgt cggagatcac
    16981 ctggctcagc gagctgacgc tggccatggt cagcaccctg gacgcggacg aggcactggg
    17041 ccggctggta cggcaactgg tgccccgcct ggcggacacc gccctgatcg acctgaccgc
    17101 cggcctcacg cgccggcgcg ccgccgccac ccaccacctg cccggcgtcc tgccctccgg
    17161 accgcacgac atcggcgagc cgttgccggg ccatcccgcc cacgacgcgg cactgtcccg
    17221 ggtgttcggc ggcgccggca cgcagcacct gaccgctccg ctgccggccg gacccgcata
    17281 tccgggaaga gacctgttcg cgctggtgga cgcccacgag gccctcgtgg tcccgttgcg
    17341 gctgcgcgcc agcacgttcg gggccctgac gctggtccgc gcgccggcca gcccgccgtt
    17401 caacgaagcc gaccggatcc tggccgagga agtggcccgc cgcgcggcac tcgggctgga
    17461 caacacccgc ctgcacgccg cccaggccga catcgccgcc accttgcagc gcgccctgct
    17521 caccgacctg cccaccgtgc cgcgcctgga gctggccgcc cactaccagc ccgcccagcg
    17581 ggcagcggaa gtcggcgggg actggtacga cgccttcctc ctggaggacg gcgacctggc
    17641 catggccatc ggcgacgtca ccggacacga catccaggcc gcctcccgca tgagcgaact
    17701 gcgcaacatg ctccgcgccc tggtcgtcga ccgccccgag gaaaaccccg gccagatcct
    17761 gcgccgcctg gacaccgccc aggcccgtct gaccctcgcc gactccgcca ccgccatcct
    17821 cacccgcctg caccccaccg cggacggaac ctgggacctg gcctggtcgg tcgccggcca
    17881 ccccccaccc ctgctgatca ccgccgacgg cacggccacc tacctcaccg gcccccgcgc
    17941 catgctgctg ggagtcaggc ccaccgcgga gcgccccacc gcccacaccc gtctgcccgg
    18001 cggagccacc ctcctgctct acaccgacgg cctggtcgaa tcccgcgcgc agccgttcga
    18061 cgtcggcatg acccgcctgc gccagtacgc caccacccac cgccagctgc ctctgcaccg
    18121 gctctgcgcc cagctcgcgc acgacctcgg cgacacccgc gacgacatca ccctcatcgc
    18181 cgcccgcacg ccccccaccg cctgacctcc gggcccgcac cgccaccttg tagcacgccc
    18241 gagggcggta cccccgggtg ccgggaatac cgccctcgtc gtaccgcgaa cagctcggct
    18301 cagtgcagcg tcttcagcga ggacgcgtcg tacgcggcca gctcggagaa ccgtccggcc
    18361 agtaccttcg ccgcccactc cgggtcctgg agcagggcgc ggccgatggc gaccaggtcg
    18421 aactccccgg actccagacg gtccaggagg tcgtcgatgc cccgcacggt ggaaccctcg
    18481 ccctggaagg ccttgaggaa ttcgccgttc aggccgaccg agccgaccga gatggcgggc
    18541 ttcccggtga tcttcttggt ccagccggcc aggttgaggt cggagccgtc gaactcgggc
    18601 tgccagtagc ggcgcgtgga ggcgtggaag gcgtccactc ccgccgccgc cagcggggcc
    18661 aggatcgcct ccagctcctc cggggtctcg gcgaggcggg cgtcgtacgc ctgctgcttc
    18721 cactgcgagt agcggaagag cacggggaag gagggggaga ccgccgaccg gaccgcggcc
    18781 acgatctccg ccgcgaactt cgtccgggcc accgggtcgc caccgtaggc gtcggtgcgg
    18841 cggttggtgc ccgcccacag gaactggtcg atcagatagc cgtgcgcgcc gtgcagttcc
    18901 acgccgtcga agccgatgcg ctcggcgtcg gccgccgcct tcgcgaacgc ctcgatgacg
    18961 tcgtccaggt cctgctgggt catggccttg ccggtgacct cggcgccctc ggtgcctatg
    19021 ccggacgggc cgaccggcgg ggcgtccgcg aacggcggct cgcccgcgcc gcgcaccatg
    19081 ccgatgtgcc acagctgcgg cacgatcgtg ccgccggcgg cgtgcacggc gtcggcgacc
    19141 ttcgaccagc cggccagctg ctcctcgccg tggaagcgcg gaatgctgtc gctctgcccg
    19201 gccgactcgt gccccacgta cgtgccctcg gtgacgatca ggccgacacc cgcggcggcg
    19261 cggcgggcgt agtacgaggc cacgtcctca ccggggatgc cgccggggga gaactgccgg
    19321 gtcatcggcg ccatcacgat ccggttcggg acggtcaggc cgttgagggt gaccggccgg
    19381 gacaggatct gtgcggcgcg gtcggtggca tcggtggtga cggtcacgcg gggctcctcg
    19441 gaacggggaa aaagagggca tgagatatgt gcgtatgcat caaccccaac cgccccgcgt
    19501 acccccgcat tccttcctac ggccccggcc cgtgtgatcc cggatacgct cgcgggctcc
    19561 cccacccact caggcggaca gtcccactca cacccgccgc ccaccggccg cagctgcacg
    19621 taaccgccct cgcgccccat gacctggccg aggcgcccgt cccgtacgtc ggccgcggac
    19681 gatcacccga ccctggtccc cgtccgcgac tccaaaaccc ccacggcccg aagctcccgt
    19741 gaagagcggt tcacgcctgt ctataaggtg tgatcgcttc gaacaccgtg cgaacaaaag
    19801 gaccctgatg ggcagacaca taagacggat ggcggccctc gccgcgcccc tggcgctcgg
    19861 cgcgacactg ctcgctccgg ccaccgccca ggcggagacc gtggtctccg ggaactacac
    19921 atcggtcttc aactacccca agcccacgac ctacgactcc tcgatcaaca cctcggtcgg
    19981 cgacctgatc gacctcgcgg ctcccagctc gaccctgtac atgggcatgt actggttcaa
    20041 cagctcggac ctgcgggcga agctcaccgc cgcccagacc cgcggcgtca cgctgcgcat
    20101 catctcggag tcggcgaacc ggcccagcag cgacctggac agcctcgcgc tgaccggcaa
    20161 ctccaccctc acctggtgct cccgcggctg cctgggcaac ggctcgggtg acacgaacgc
    20221 gatcgaccac gacaagtacc tcgtgctcga ctcgctcacc gacggacgca agaacgtcgt
    20281 ctggcaggcc tcgcagaacc tcgcgggcgg ccaggacggc gagatcaaca acgcggtcgt
    20341 cgtgtccggc aacgcgaccc tcgcgtcccg gtaccgcgcg cacttcaacg accaggtgaa
    20401 gcacgccggc gacagcctgc acacgacgta cgactactcc accggcgacc cgagctcccc
    20461 ggtcgaggcg tacttctccc cgcgcgacac cgcctcggac gccgcccact acggcaacgc
    20521 cgacatcctc gcctcgttca tcgaccaggt cgactgctcg aacgacggaa agatcaggat
    20581 ctcggccgcc gaactcgacc agcggaccac ccgcccggcc gtctacgacg ccctggcgac
    20641 gaagcggtcc cagggatgca gcgtcgacgc gaacgcccgc gacctcagtg acggcggcgg
    20701 caacgacggc atcaacgacc tgaccgccct cgacatcgcg gcctacggca accgccccgg
    20761 cggctgccgc tacaagacct ccgcaggggc ctcctgcaac cacggcacca cccactccaa
    20821 gtacctgctg acggagtgga agaagagcga cggcacccag gtccagcacg tgtacacggg
    20881 ctcccacaac tggaccgcgg gctcgctgaa gacgaacgac gagacgattc tgcgcatcga
    20941 cgacgcgggc acctaccagg cctacgtcgc caacttcaac aaggtgcgcg cgagcgcggt
    21001 cgacctcg
//
