LOCUS       NC_003155              21086 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3780127
            Orig. end                         :: 3801213
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11086)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(847..862)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.52"
                     /tool="antismash"
     gene            978..1232
                     /db_xref="GeneID:41540105"
                     /locus_tag="SAVERM_RS15705"
                     /old_locus_tag="SAV_3024"
                     /old_locus_tag="SAVERM_3024"
     CDS             978..1232
                     /codon_start=1
                     /db_xref="GeneID:41540105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437917.1"
                     /locus_tag="SAVERM_RS15705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3024"
                     /old_locus_tag="SAVERM_3024"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_010984454.1"
                     /transl_table=11
                     /translation="MSETPEVKPPVVTPVRVVIALCLIAPFVAMLWVGSYAKVDPTFIG
                     IPFFYWYQMLWVLISTALTMTAYQLWQRDQRARKGGEGQ"
     gene            1229..2857
                     /db_xref="GeneID:41540106"
                     /locus_tag="SAVERM_RS15710"
                     /old_locus_tag="SAV_3025"
                     /old_locus_tag="SAVERM_3025"
     CDS             1229..2857
                     /codon_start=1
                     /db_xref="GeneID:41540106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="SAVERM_RS15710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3025"
                     /old_locus_tag="SAVERM_3025"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_037649004.1"
                     /transl_table=11
                     /translation="MKDGVNGVALGVFVFFFLAVTVLGFLAARWRKAENEHSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     EGTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDGLIYLVIAVAIIYIPIKLGG
                     FDDIFAKAGEAFSQTNPATGKPRGALAPAEAGQWTYATLALGSALALFMYPHSITATLS
                     SRSRDVIRRNTTILPLYSLMLGLLALLGFMAIAAGIKVQNGQLAIPQLFETMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPAQETKVSKLVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTLAAY
                     GVASPTQKHFGGSSKEIPGIGEIGYIGLTAFVLNVVVTVVLTFALKALKAPDGIDETSP
                     EDYTADAGDPGVEVELPPATAGATH"
     misc_feature    2987..3001
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 26.1"
                     /tool="antismash"
     misc_feature    3018..3032
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    3026..3039
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     regulatory      3054..3147
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            3293..5674
                     /db_xref="GeneID:41540107"
                     /locus_tag="SAVERM_RS15715"
                     /old_locus_tag="SAV_3026"
                     /old_locus_tag="SAVERM_3026"
     CDS             3293..5674
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="SAVERM_RS15715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3026"
                     /old_locus_tag="SAVERM_3026"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_010984456.1"
                     /transl_table=11
                     /translation="MTIAPADPASVTTSVTSAETDGPGTALLRTLTDLTADLPDADPGR
                     VAAAALRGRSARADEAELRELATEAAAGLISEDPAYSRLAARLLTISIAEEAASQGVTS
                     FSASITVGHREGLVADRTADFVRLHTARLDALIDTGADDRFGYFGLRTLHSRYLLRHPI
                     TRRVIETPQHFMLRVASGLAEDDTSHAVDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQ
                     MSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIV
                     PFLKTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHW
                     IPDEFMRRVNENGVWSLFSPADVPELVDLWGDEFDAAYRKAEEAGLAKKTIPARDLYGR
                     MMRTLAQTGNGWMTFKDAANRTANQTAEPGHVVHSSNLCTEILEVTDDGETAVCNLGSV
                     NLGAFVVGRDIDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMGLQ
                     DVFFKLRLPFDSPEAQALSTRIAERIMLAAYEASADLAERNGPLPAWEKTRTARGVLHP
                     DHFDVELTWPERWAALRERIAAVGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKR
                     ETLSGEFLQVNSYLVDELKQLGVWDAQTREALRESGGSVQGFTWVPQDVRDLYRTAWEI
                     PQRGLIDMAAARTPFLDQAQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATR
                     IARAAQAQAQPEKTIPVQQVSEPDAVACSLENPESCEACQ"
     gene            5674..6687
                     /db_xref="GeneID:41540108"
                     /locus_tag="SAVERM_RS15720"
                     /old_locus_tag="SAV_3027"
                     /old_locus_tag="SAVERM_3027"
     CDS             5674..6687
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657910.1"
                     /locus_tag="SAVERM_RS15720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3027"
                     /old_locus_tag="SAVERM_3027"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_037649006.1"
                     /transl_table=11
                     /translation="MSSETKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLAKLTPAEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPEDRTAAFAAVENIPSIREKAEFCFKWINEVEKLDRLETKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFE
                     VVDTVRKEEPELFDDELQQQVTDMLREAVEAELQFGRDLCGDGLPGMNTESMRQYLECV
                     ADQRLQRLGFAPVYGSENPFSFMELQGVQELTNFFERRASAYQVAVEGTVDLDEDF"
     gene            6836..7291
                     /db_xref="GeneID:41540109"
                     /locus_tag="SAVERM_RS15725"
                     /old_locus_tag="SAV_3028"
                     /old_locus_tag="SAVERM_3028"
     CDS             6836..7291
                     /codon_start=1
                     /db_xref="GeneID:41540109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072159.1"
                     /locus_tag="SAVERM_RS15725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3028"
                     /old_locus_tag="SAVERM_3028"
                     /product="hypothetical protein"
                     /protein_id="WP_037649009.1"
                     /transl_table=11
                     /translation="MRRTTHHRTIALATLTLVLAGCGTQNGSGPGGSGTVSPSPSTTGE
                     GCTAQTELSAADSGRTVCVPTGGVIRLSLDGTRDRPWQPVAVSGGGLEATNSGIVLQPG
                     DAVSAFRAVSAGKARLTSSRPLCVTDPARASCKGLQEWTVTVVVTKA"
     gene            complement(7252..7458)
                     /db_xref="GeneID:43933264"
                     /locus_tag="SAVERM_RS43060"
                     /old_locus_tag="SAV_3029"
                     /old_locus_tag="SAVERM_3029"
     CDS             complement(7252..7458)
                     /codon_start=1
                     /db_xref="GeneID:43933264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019992372.1"
                     /locus_tag="SAVERM_RS43060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3029"
                     /old_locus_tag="SAVERM_3029"
                     /product="hypothetical protein"
                     /protein_id="WP_042493129.1"
                     /transl_table=11
                     /translation="MNALMDNLAGILTVLVIFVVLALPALIGLAHERRIDRQLREAAGR
                     SHREAGPPQRPQAFVTTTVTVHS"
     misc_feature    complement(7451..7462)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            7553..8533
                     /db_xref="GeneID:41540111"
                     /locus_tag="SAVERM_RS15735"
                     /old_locus_tag="SAV_3030"
                     /old_locus_tag="SAVERM_3030"
     CDS             7553..8533
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540111"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326964.1"
                     /locus_tag="SAVERM_RS15735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3030"
                     /old_locus_tag="SAVERM_3030"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_010984460.1"
                     /transl_table=11
                     /translation="MLTNVVAVLLDGVHPFELGVVCEVFGIDRSDEGLPVYEFAVASAE
                     GPTLRTHAGFSLRTEHGLERLETADLITLPAGNSYVSRGYPPELLDALRRAVDRGARLL
                     SVCSGVFVLGAAGLLDGRRCAVHWHHADELARQYPKAIVEPDVLYVDEDPVITSAGTAA
                     GIDACLHIVRKEQGPEVANAIARRMVVPPHRDGGQAQYIERPLPRSPCDTVGEVLVWME
                     QHLDEEVTVEQLAARAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEVTDETMD
                     AIAGRTGFGTAAALRHQFVRSLGTTPNAYRRTFRGPATGPLGLAG"
     gene            complement(8634..10004)
                     /db_xref="GeneID:41540112"
                     /locus_tag="SAVERM_RS15740"
                     /old_locus_tag="SAV_3031"
                     /old_locus_tag="SAVERM_3031"
     CDS             complement(8634..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540112"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326965.1"
                     /locus_tag="SAVERM_RS15740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3031"
                     /old_locus_tag="SAVERM_3031"
                     /product="cytochrome P450"
                     /protein_id="WP_010984461.1"
                     /sec_met_domain="p450 (E-value: 4.1e-66, bitscore: 222.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLESVKPEAPEAPQLRNPPLAGGGIPGLGHGWKLARDPLGFLAQ
                     LRDHGDIVRLKLGPKTMYAVTTPALTGELALSPDYEIGGPLWESLEGLLGKHGVATANG
                     PTHRRQRRTIQPAFRLDIIPEYGPIMEEEARAFAARWQPGEIIDCTSESFRVAVRIAAR
                     CLLRGHYMDERAERLSIALTTVFRGMYRRMVIPAGPLYRLPLPANRKFDRALADLHLLV
                     DEIVAERRASGQKPDDLLTALLEAKDDNGDPITEQEIHDQVVAILTPGSETIASTIMWL
                     LQVLTEHPEHAAKVCAEVESVTGDRTVAFDDVRKLSHTNNVVVEAMRLRPAVWILTRRA
                     VTETELGGYRIPAGADIVYSPYAIQRDPRSYAEHLEFDPDRWLPERSKDLPKYAMRPFS
                     LGNRKCPSDHFSMAQLTLITATVAAKWRFEQVSESSDATRVGITLRPHRLLLKAIPR"
     gene            complement(10001..11086)
                     /db_xref="GeneID:41540113"
                     /gene="cyc1"
                     /locus_tag="SAVERM_RS15745"
                     /old_locus_tag="SAV_3032"
                     /old_locus_tag="SAVERM_3032"
     CDS             complement(10001..11086)
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540113"
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="SAVERM_RS15745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3032"
                     /old_locus_tag="SAVERM_3032"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_107083301.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-62, bitscore: 210.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAFPHSTSPTTTVIAVPPALSLPVIETDFPRQLHPYWPRLQEKT
                     RSWLLEKRLMPADKVEEYADGLCYTDLMAGYYIGAPDEVLQAIADYSAWFFVWDDRHDR
                     DVIHRRATAWRQLRFQLHTALDSPRDHLHHRDPLVAGFADSMVRLYSFLGKKWNARFAC
                     HFHAVIEAYDREFHNRTRGIVPTVEEYLELRRLTFAHRIWTDLLEPSARHEIPAGVREH
                     PGYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLIHHEGLTLEEAVTEVRRRVE
                     ECIAEFLVAEKEAVHLADGLADGTRAGHELSDAVKACVANMRNWFSTVYWFHHESGRYR
                     VDSWDDRSTPPYVNNEAAGEK"
     misc_feature    11366..11380
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.01"
                     /tool="antismash"
     gene            complement(11424..12074)
                     /db_xref="GeneID:41540114"
                     /gene="def"
                     /locus_tag="SAVERM_RS15750"
                     /old_locus_tag="SAV_3033"
                     /old_locus_tag="SAVERM_3033"
     CDS             complement(11424..12074)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540114"
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="SAVERM_RS15750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3033"
                     /old_locus_tag="SAVERM_3033"
                     /product="peptide deformylase"
                     /protein_id="WP_010984463.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHTGVLPVDDDGFVIDAEDCEEREAAYRERGTSRPIT
                     VVGNPVLHKECKDVTDFGAELEQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCQDD
                     EGTRHVGVVCNPKLVDLPADRRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND"
     gene            complement(12148..13128)
                     /db_xref="GeneID:41540115"
                     /locus_tag="SAVERM_RS15755"
                     /old_locus_tag="SAV_3034"
                     /old_locus_tag="SAVERM_3034"
     CDS             complement(12148..13128)
                     /codon_start=1
                     /db_xref="GeneID:41540115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="SAVERM_RS15755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3034"
                     /old_locus_tag="SAVERM_3034"
                     /product="hypothetical protein"
                     /protein_id="WP_010984464.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRVPGGATASGEPVGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTAAGHAYPVFDEIELWAPSPVPTWVVLLEAATEDDRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGIAAPAALVRGLLDGWVADSPDSRGWRDLEEVC"
     gene            complement(13270..14463)
                     /db_xref="GeneID:41540116"
                     /locus_tag="SAVERM_RS15760"
                     /old_locus_tag="SAV_3035"
                     /old_locus_tag="SAVERM_3035"
     CDS             complement(13270..14463)
                     /codon_start=1
                     /db_xref="GeneID:41540116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444569.1"
                     /locus_tag="SAVERM_RS15760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3035"
                     /old_locus_tag="SAVERM_3035"
                     /product="HD domain-containing protein"
                     /protein_id="WP_237529343.1"
                     /transl_table=11
                     /translation="MLLGAAALADTLWHGVDRPGDALAFGLLVAVGELARWSGAGERAS
                     APLGAAGALAYALLGENAGHPTHHGALQVVAVVVAAALLGCVPHVARGGPTADHLTRRV
                     LTVGFAALCFQPLYERGRLHEWGGPAHALLLVALLLLTALCDALLAAVMAHSRTRWPFG
                     PLLRDELRAMLGIGSAVCATGAVMSLAVAVVGLWALPVFSLPLLLTQFSFRRYAAVRVT
                     YTQTIASLARATEIAGCTPAGHARRVAVLSRAVGRELGLSGPELTVLEYAALMHDIGQL
                     SLVDPVPAGATAVLSADEQRRIALLGGAVVRQTGVNAEVAVVVERQADPYREQPVSARI
                     VRAVNAYEEMVRAAGPGGPLTALEKLRLGTARDYQPEVVESLARVLSRDGLTLPSAG"
     gene            complement(14595..16016)
                     /db_xref="GeneID:41540117"
                     /locus_tag="SAVERM_RS15765"
                     /old_locus_tag="SAV_3036"
                     /old_locus_tag="SAVERM_3036"
     CDS             complement(14595..16016)
                     /EC_number="3.1.4.-"
                     /codon_start=1
                     /db_xref="GeneID:41540117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058307.1"
                     /locus_tag="SAVERM_RS15765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3036"
                     /old_locus_tag="SAVERM_3036"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_037649015.1"
                     /transl_table=11
                     /translation="MGSVPARGRVYVLCTAVAALACLAPAATVRVPWWVVALLAGLYAG
                     CEQITFPRVRPGRGEVSGGTGGDGSRPAGRRVPAGMGTLFPVLLAGAFLLPPSAAALVP
                     LPGALLARVERRPRWLRRIWHAAQLALCTWAASRAHGALGGRAAVASPDFPYALVPAGA
                     AVLAFCAVLTALDGGILALAERVPVRGAWRGLFPRSLAPVAVHGLAGLMMAVLWRSPYG
                     PVAALLVLLPMYVSCWVFAQYHRERAAHQATIRALVQAVDIKDGYTRGHSERVGQASMM
                     IARELGMDDERAEVLRFAGILHDVGKLGVPTRLLRKDGPLTPEERRIIELHPEYGHEMV
                     RGIGFLGEARSAILHHHERLDGSGYPYGLTGAQIPEFARVVAVADAFDAMTSTRSYRRA
                     RPVAAALEELERCAGAQFDPVMVGALVRALGRQGWHPAVTADENVPPGVCPPAPPVSSR
                     LESRSHRNGVGGGGA"
     gene            complement(16210..16521)
                     /db_xref="GeneID:41540118"
                     /gene="rsrA"
                     /locus_tag="SAVERM_RS15770"
                     /old_locus_tag="SAV_3037"
                     /old_locus_tag="SAVERM_3037"
     CDS             complement(16210..16521)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540118"
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="SAVERM_RS15770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3037"
                     /old_locus_tag="SAVERM_3037"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_010984467.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDHEMPDSDCTKFEVHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPTDLRAKVMGRIDLIRSGQTVPEHDVTAAPATPQES"
     gene            complement(16518..17201)
                     /db_xref="GeneID:41540119"
                     /gene="sigR"
                     /locus_tag="SAVERM_RS15775"
                     /old_locus_tag="SAV_3038"
                     /old_locus_tag="SAVERM_3038"
     CDS             complement(16518..17201)
                     /codon_start=1
                     /db_xref="GeneID:41540119"
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="SAVERM_RS15775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3038"
                     /old_locus_tag="SAVERM_3038"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_010984468.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTDNGQAEQPEGQGTSTESTAERSARFERDALEFLD
                     QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK
                     QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKSALQAIPEEFRIAV
                     YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEA
                     KGSGS"
     misc_feature    17257..17271
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     misc_feature    17389..17404
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            complement(17447..18082)
                     /db_xref="GeneID:41540120"
                     /locus_tag="SAVERM_RS15780"
                     /old_locus_tag="SAV_3039"
                     /old_locus_tag="SAVERM_3039"
     CDS             complement(17447..18082)
                     /codon_start=1
                     /db_xref="GeneID:41540120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480453.1"
                     /locus_tag="SAVERM_RS15780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3039"
                     /old_locus_tag="SAVERM_3039"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_010984469.1"
                     /transl_table=11
                     /translation="MAEITELIETDAGTARITWHKARKASLVLAVSHGAGGGIEARDLQ
                     ALARVLPGHGVTVALVEQPWRVAGKKVAPAPKTLDVGWRGLWPAVAKAGLPVIAGGRSA
                     GARGACRTATELGAAAVLALSFPLHPPGKPEKSRADELLGAGVPTLVVQGGNDPFGKPE
                     EFPNGSYELVEVPYGDHGFAVPKRAPLGQEQALAIITDRVVEWTASLG"
     gene            complement(18084..18923)
                     /db_xref="GeneID:41540121"
                     /locus_tag="SAVERM_RS15785"
                     /old_locus_tag="SAV_3040"
                     /old_locus_tag="SAVERM_3040"
     CDS             complement(18084..18923)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="SAVERM_RS15785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3040"
                     /old_locus_tag="SAVERM_3040"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_010984470.1"
                     /transl_table=11
                     /translation="MCGRYAASRGPEDLAGVFEVEKWEPEESLAPDFNVAPTKDVYAVL
                     DRPLKDADTASTSSSVPGRPVRQLRKLKWGLVPSWSKTPEGGARMINARAETVHEKPSY
                     RRAFAARRCILPADGYYEWVTGSQERELEVEGRKKRPRKQPYFVLPADGSVFAMAGIYE
                     FWRDRTLPDDHPGAWWVTCSVITTEAETSPLAVAPAEGPYALADIHPRMPLMLTPDRWD
                     AWLDPARTDTDDLRELLAPPPAGLMRAYPVSTAVSNVRNNGPELLKELEGPEEGTLF"
     gene            19030..19761
                     /db_xref="GeneID:41540122"
                     /locus_tag="SAVERM_RS15790"
                     /old_locus_tag="SAV_3041"
                     /old_locus_tag="SAVERM_3041"
     CDS             19030..19761
                     /codon_start=1
                     /db_xref="GeneID:41540122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072146.1"
                     /locus_tag="SAVERM_RS15790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3041"
                     /old_locus_tag="SAVERM_3041"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_010984471.1"
                     /transl_table=11
                     /translation="MDSTASTSLSSLTDLWDQVFGSQPDPDLWVVIATMVAALAVIVPH
                     NVWRLSRNAITIAHEGGHGLIALLTGRTLTGIRLHSDTSGLTVSRGKPHGLGMILTAAA
                     GYTAPPLLGLGGAALLAAGHITALLWLATVLLIAMLVMIRNAYGALTVLLTGGTFVVVS
                     WLAGPQVQAAFAYAVVWFLLIGGVRPAFELQAKRSRGNAGDSDADQLSRLTRVPAGLWL
                     FLFHAVSLCSLIGGGRWLLEV"
     misc_feature    20997..21015
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.25"
                     /tool="antismash"
ORIGIN
        1 gagaacgagg gcggggcacc catccgtacc gcgcgtgtgc ccaagtacta ccgcctgaag
       61 aagcacctgc tcgacatgac ggagacgctg ccgcccggca cacccgtgcc gcccgagcgc
      121 acgctggccg ccgagttcga cacctcccgc acgaccgtcc gccaggccct ccaggagctg
      181 gtcgtcgagg gccgcctgga gcgcatccag ggcaagggca cgttcgtcgc caagccgaag
      241 gtctcccagg cgctgcaact cacctcgtac accgaggaca tgcgcgccca gggtctcgaa
      301 ccgacctcgc agctcctgga catcggctac atcaccgcgg acgacaccct cgccgggctg
      361 ctcgacatca ccgcgggcgg ccgcgtgctg cgcatcgagc ggctgcgcct ggccagcggc
      421 gagccgatgg ccatcgagac gacccatctg tccgccaagc gcttccccgc gctgcgcagg
      481 tcgctggtca agtacacgtc gctctacacc gcgctcgccg aggtctacga cgtccgtctc
      541 gccgaggccg aggagaccat cgagacctcg ctggccaccc cgcgcgaggc cggactgctg
      601 ggcaccgacg tcggcctgcc catgctgatg ctctcgcggc actcgctgga caaggacggc
      661 cggccggtgg agtgggtgcg gtcggtgtac cgcggggacc gctacaagtt cgtggcgaga
      721 ctcaagcgcc cccaggactg aggccgaggc gcccgcagtg cgcacgggcc gtcaggaggc
      781 ggtgtcccgc gcggtcttcg gcgcggcctt tcgcgcggcc tttcgcgcgg ccttccccac
      841 ggcctttcgc acggcctttc gttgccgatg agcagtacgt cacatccgtt atgcggacgg
      901 gggttccata aagcggaacc gtcgcttaga tttcctgcgc gttgcacagg tgatcagcga
      961 agggacggag ccgtggcatg tccgaaacgc ctgaagtgaa accaccggtg gtgacaccgg
     1021 tccgggtggt catcgccctc tgtctgatcg ccccgttcgt ggcgatgctg tgggtcggtt
     1081 cctacgcgaa ggtcgacccg accttcatag gcatcccctt cttctactgg taccagatgc
     1141 tgtgggtgct catctccacg gcgctcacca tgaccgcgta ccagctgtgg cagcgcgacc
     1201 agcgcgcccg caagggaggt gaggggcagt gaaggacggt gtgaacggag tcgccctcgg
     1261 cgtcttcgtc ttcttcttcc tggccgtcac cgtgctgggc ttcctggcgg cacggtggcg
     1321 caaggccgag aacgagcaca gcctggacga atggggtctg ggcggccggt cgttcggcac
     1381 ctgggtcacc tggttcctgc tcggcggcga cctctacacg gcgtacacct tcgtcgccgt
     1441 accggcggcg atctacgcgg cgggcgcggc gggcttcttc gcggtgccgt acacgatcct
     1501 cgtctacccg ctgatcttca ccttcctgcc ccgcctctgg tcggtgtcgc acaagcacgg
     1561 atatgtgacg acgtccgact tcgtgcgcgg ccggttcggc tcgaagggcc tgtccctggc
     1621 ggtggcggtc accggcatcc tggcgaccat gccgtacatc gcgctccagc tggtcggcat
     1681 ccaggccgtc ctcgacgtca tgggcgtggg cggcggcgag ggcaccaact ggttcgtcaa
     1741 ggacctgccg ctgctgatcg ccttcggcgt cctggccgcg tacacgtact cctcggggct
     1801 gcgcgccccc gccctcatcg cgttcgtgaa ggacgggctg atctatctcg tcatcgcggt
     1861 cgcgatcatc tacatcccga tcaagctggg cggcttcgac gacatcttcg ccaaggcggg
     1921 cgaggcgttc tcccagacca acccggcgac cggcaaaccg cgcggggcgc tcgcaccggc
     1981 cgaggcgggc cagtggacgt acgcgacgct ggcgctgggc tccgccctgg cgctgttcat
     2041 gtacccgcac tcgatcacgg cgacgctgtc ctcgcgcagc cgtgacgtga tccgccgcaa
     2101 caccacgatc ctgccgctct actccctgat gctgggcctg ctcgcgctgc tcggcttcat
     2161 ggccatcgcg gccggcatca aggtccagaa cgggcagctg gccatcccgc agctgttcga
     2221 gacgatgttc ccggactggt tcgcgggcgt cgccttcgcg gcgatcggca tcggcgcgct
     2281 ggtcccggcg gcgatcatgt cgatcgcggc cgcgaacctc ttcacccgca acatctacaa
     2341 ggacttcatc aagccggacg cgaccccggc gcaggagacc aaggtctcca agctcgtgtc
     2401 gctgctggtg aaggtgggcg cgctggtctt cgtcctgacg atggacaaga cggtggcgat
     2461 caacttccag ctgctcggcg gcatctggat cctgcagacc ttcccggccc tggtcggcgg
     2521 gctgttcacc cgctggttcc accgctgggc gctgctcgcg ggctgggcgg tcggcatggt
     2581 gtacggcacg ctggccgcgt acggcgtcgc gtccccgacc cagaagcact tcggcggcag
     2641 ctcgaaggag atcccgggga tcggggagat cggctacatc ggcctgacgg cgttcgtgct
     2701 gaacgtggtg gtcaccgtgg tcctcacctt cgccctgaag gccctcaagg cccccgacgg
     2761 catcgacgag acctcgccgg aggactacac ggcggacgcc ggcgacccgg gcgtcgaggt
     2821 ggaactgccg ccggccacgg cgggcgccac gcactgagcg cgacgcaccg agtcgtaggt
     2881 gcgtgcgcag gcgcctagat gcgtaggtat gtaggtacac gggcacatga cacgggccgc
     2941 cgggaaatcc ggcggcccgt cgtcgtacct ctccggcacc gacgggacac aagatgtggg
     3001 ggtgccaccg gggcccggca caagatgtat gctcatgctc gctgtcgccg caggggaatc
     3061 cggtgcgaat ccggaactgt cccgcaacgg tgtacttgtg cgtgttcgcg tatttcgctg
     3121 ccacgtgctc gcttcagtcc gaggacctgt cgacagcgcg ccccggccga ccggcccggg
     3181 tgccatgacg tccgggcctc gcggagtggg ccggtggacg cgcgcgtgcc tgccgtgccg
     3241 tgcgccctgc tgccctccaa caggccccgt gccgagcgag ggagagcccc acgtgaccat
     3301 cgcgccagcc gatccggctt cagtgacaac gtcggtgaca tcggcggaga cggacggtcc
     3361 cggtaccgcg ctgctgcgga ccctgaccga cctcaccgcc gacctccccg acgccgaccc
     3421 cggccgggtc gccgccgccg ctctgcgcgg ccggtccgcc cgggcggacg aagcggagct
     3481 gcgcgagctg gccaccgagg cggccgcggg tctcatctcc gaggaccccg cgtactcgcg
     3541 gctggccgcc cggctgctga ccatcagcat cgccgaggag gccgcctcac agggcgtcac
     3601 gtcgttctcc gcgtcgatca cggtcgggca ccgcgagggc cttgtcgccg accgcaccgc
     3661 cgacttcgta cggctgcaca ccgctcgcct ggacgcgctg atcgacaccg gcgccgacga
     3721 ccgcttcggc tacttcgggc tgcgcaccct gcacagccgc tatctgctgc ggcacccgat
     3781 cacccggcgc gtgatcgaga ccccgcagca cttcatgctc agggtcgcct ccggcctcgc
     3841 cgaggacgac acctcgcacg ccgtcgacga agtggccgcc ctgtacgggc tgatgagccg
     3901 cctggactac ctcccctcct cccccacgct cttcaactcc ggtacgcggc acccgcagat
     3961 gtcgtcctgc tacctcctcg actccccgct ggacgagctg gactccatct acgaccgcta
     4021 ccaccaggtg gcccggctct ccaagcacgc gggcggcatc ggcctctcgt acagccggat
     4081 ccgctcgcgg ggctccctga tccgcggcac gaacgggcac tccaacggca tcgtcccgtt
     4141 cctgaagacc ctcgacgcct cggtcgccgc ggtgaaccag ggcggccggc gcaagggcgc
     4201 ggccgcggtc tacctggaga cctggcactc cgacatcgag gagttcctgg agctgcgcga
     4261 caacaccggt gaggacgccc ggcgtacgca caacctgaac ctggcgcact ggatcccgga
     4321 cgagttcatg cgccgggtca acgagaacgg cgtctggtcg ctgttctccc cggccgacgt
     4381 gcccgagctg gtcgacctgt ggggcgacga gttcgacgcc gcgtaccgca aggccgagga
     4441 ggcgggcctc gccaagaaga ccatcccggc ccgcgacctg tacggccgca tgatgcgcac
     4501 cctcgcgcag accggcaacg gctggatgac cttcaaggac gccgccaacc gcaccgccaa
     4561 ccagacggcg gagccgggcc acgtcgtcca ctcctcgaac ctgtgcaccg agatcctgga
     4621 ggtcacggac gacggggaga cggcggtctg caacctcggt tcggtgaacc tgggcgcgtt
     4681 cgtggtcggc cgggacatcg actgggagcg cctcgacgcc accgtccgca ccgccgtgac
     4741 cttcctcgac cgggtcgtcg acatcaactt ctacccgacc gagcaggccg gccgctccaa
     4801 cgccaggtgg cgtccggtgg gcctgggcgc gatgggcctc caggacgtct tcttcaagct
     4861 gcggctgccc ttcgactcgc ccgaggccca ggcgctctcc acgcgcatcg ccgagcgcat
     4921 catgctcgcc gcgtacgagg cgtccgccga cctcgccgag cgcaacggac cgctgcccgc
     4981 ctgggagaag acccgtaccg cccgtggcgt gctgcacccc gaccacttcg acgtcgagct
     5041 gacctggccc gagcgctggg cggccctgcg ggaacgcatc gccgccgtgg gcatgcgcaa
     5101 ctccctcctg ctcgccatcg cccccaccgc caccatcgcg tccatcgcgg gtgtctacga
     5161 gtgcatcgag ccgcaggtct ccaacctgtt caagcgcgag acgctgtccg gcgagttcct
     5221 ccaggtcaac tcctacctgg tggacgaact gaagcagctc ggcgtgtggg acgcgcagac
     5281 ccgggaggcg ctgcgcgagt cgggtggctc ggtgcagggc ttcacctggg tcccgcagga
     5341 cgtccgcgat ctgtaccgca cggcgtggga gatcccgcag cgcgggctca tcgacatggc
     5401 cgcggcccgg accccgttcc tggaccaggc ccagtcgctg aacctgttcc tggagacgcc
     5461 gaccatcggc aagctctcct cgatgtacgc gtacgcctgg aagtcgggcc tgaagacgac
     5521 gtactacctg cgctcccgcc cggcgacccg catcgcccgc gccgcccagg cccaggcaca
     5581 gcccgagaag accatccccg tccagcaggt gtccgagccc gacgccgtcg cctgctccct
     5641 tgagaacccc gagtcctgcg aggcctgcca gtgatgtcca gcgaaaccaa gaacctgctc
     5701 gacccgggct tcgaactcac cctgcgcccc atgcgctacc cggacttcta cgagcgctac
     5761 cgggacgcga tcaagaacac ctggaccgtc gaggaggtcg acctccactc ggacgtcgcc
     5821 gacctcgcga agctgacgcc tgccgagcag cacctgatcg gccgcctggt cgcgttcttc
     5881 gcgacgggcg actcgatcgt cgcgaacaac ctggtgctga cgctgtacaa gcacatcaac
     5941 tcccccgagg cgcggctcta cctgagccgt cagctcttcg aggaagccgt gcacgttcag
     6001 ttctatctga cgctgctcga cacctatctg cccgaccccg aggacaggac ggcggccttc
     6061 gcggccgtcg agaacatccc gtccatccgt gagaaggccg agttctgctt caagtggatc
     6121 aacgaggtcg agaagctcga ccggctggag acgaaggccg accgccgccg tttcctgctc
     6181 aacctgatct gcttcgccgc gtgcatcgag ggcctcttct tctacggcgc cttcgcgtac
     6241 gtctactggt tccgcagccg gggtctgctg cacggtctcg ccaccggcac caactgggtg
     6301 ttccgtgacg agacgatgca catgtccttc gcgttcgagg tggtcgacac cgtccgcaag
     6361 gaggagccgg agctcttcga cgacgagctt cagcagcagg tcaccgacat gctgcgggag
     6421 gccgtcgagg cggagctcca gttcgggcgc gacctgtgcg gcgacggcct gccgggcatg
     6481 aacaccgagt cgatgcggca gtacctggag tgcgtcgccg accagcgcct ccagcgcctc
     6541 ggcttcgcgc cggtgtacgg ctccgagaac ccgttctcct tcatggagct ccagggcgtc
     6601 caggagctga ccaacttctt cgagcggcgc gcgtccgcgt accaggtcgc ggtggagggc
     6661 acggtcgacc tcgacgagga cttctgacgg ttcagcccgc tcagcaccgg acgacgccgg
     6721 gccgcacacg cggcccggcg tcgtcatgtc ccgccctccg gccgcacccg gaagaccttc
     6781 ggtgagtgga tcctggtgca cgggtgacac gtccaagcgg caaggaggcc acgccatgcg
     6841 ccgaacgacc caccaccgga cgatcgccct cgcgacactg acgctcgtcc tcgcgggctg
     6901 cggcacgcag aacggaagcg gcccgggcgg cagcggcacc gtgtccccgt ccccctcgac
     6961 gaccggcgaa ggctgtacgg cacagacgga gctgagcgcc gccgacagcg gccgtacggt
     7021 ctgtgtgccg acgggcggtg tgatccgcct cagcctggac ggcacccgcg acaggccctg
     7081 gcagcccgtc gccgtcagtg gcggcggtct cgaagccacc aacagcggca tcgtcctcca
     7141 gccgggcgac gccgtctccg ccttcagggc ggtctcggcc gggaaggcac ggctcacctc
     7201 gtcccgcccg ctgtgcgtca ccgacccggc cagggcgtcg tgcaagggcc ttcaggagtg
     7261 gacggtgacg gtggtggtga cgaaggcctg aggccgctgc ggcggaccgg cctcccggtg
     7321 ggagcggccg gccgcctccc tgagctgacg gtcgatccgc ctttcgtggg cgaggccgat
     7381 cagtgcgggg agggccagca ccacgaagat gacgaggacg gtcagtattc cggcgaggtt
     7441 gtccatgagt gcgttcatgg acaccactgt cgcgccgatc actccttacc tgtcagtggc
     7501 aggactgccg tagaccctcg aattactgcc agctctacgg cacactggca gcatgctcac
     7561 caacgtggtc gccgtcctgc tcgacggcgt gcatcccttc gaactcggcg tcgtctgcga
     7621 ggtgttcggc atcgaccgca gcgacgaggg cctgcccgtg tacgagttcg cggtcgcgtc
     7681 cgccgagggc ccgaccctgc gcacgcacgc ggggttctcg ctgcgcacgg agcacggcct
     7741 ggaacggctg gagacggccg acctcatcac cctgcccgcc gggaactcct atgtctcccg
     7801 cggctatcca cccgaactgc tcgacgccct gcgccgcgcg gtcgaccgcg gtgcccggct
     7861 gctcagcgtc tgttccggcg tcttcgtgct gggcgcggcc gggctcctcg acgggcggcg
     7921 ctgcgccgtg cactggcacc acgcggacga actcgcccgg cagtacccga aggcgatcgt
     7981 cgagccggac gtgctgtacg tcgacgagga ccccgtcatc acctcggccg gtacggccgc
     8041 cgggatcgac gcctgcctcc acatcgtccg caaggagcag ggccccgagg tcgccaacgc
     8101 catcgcccgc cgcatggtgg tgccgccgca ccgcgacggc ggccaggccc agtacatcga
     8161 gcggccgctg ccccgctccc cctgcgacac ggtcggcgag gtgctggtgt ggatggagca
     8221 gcacctcgac gaggaggtca ccgtcgaaca gctggcggcc cgcgcgcaca tgtccccgcg
     8281 caccttcgcc cgccgcttcc agcaggagac gggcacgact ccgtaccgct ggatcctgcg
     8341 ccaacgtgtg ctgctggccc agcggttgct ggaggtgacg gacgagacga tggacgcgat
     8401 cgcgggccgg accggattcg ggaccgcggc cgccctgcgc catcagttcg tccggtcgct
     8461 ggggacgacc ccgaacgcgt accggcgtac gttccgggga ccggccacgg ggccgctcgg
     8521 tctcgccggg tgacggtcgg gcaggactcc cggtcggacg ggtccggtcc atgaacgcgg
     8581 ggtgcgcccc cgcacacctc ctggcgaggc aacgagggtg caccccgggg cgttcagcgc
     8641 ggtatggcct tcagcagcag ccggtggggg cgcagcgtga tgccgacgcg cgtcgcgtcg
     8701 ctcgactcgg acacctgctc gaagcgccac ttggcggcca ccgtcgccgt gatgagggtg
     8761 agctgggcca tcgagaagtg gtcactcggg cacttgcggt tgcccaggct gaacgggcgc
     8821 atcgcgtact tcgggaggtc cttggagcgc tccggaagcc agcggtcggg gtcgaactcc
     8881 aggtgctccg cgtacgagcg ggggtcgcgc tggatcgcgt acgggctgta cacgatgtcg
     8941 gcaccggccg gaatgcgata cccgccgagt tcggtttcgg tcaccgcccg ccgcgtcaat
     9001 atccatacgg cggggcgcag ccgcatcgcc tccacgacca cattgttcgt gtgcgaaagc
     9061 ttccggacgt cgtcgaatgc aacggtccgg tcacccgtga cggattcgac ctccgcacac
     9121 accttggccg catgttccgg gtgttccgtg aggacttgca ggagccacat gatcgtggat
     9181 gcgatggttt cactgccggg ggtgagtatg gcgacgactt ggtcgtggat ctcctgttcc
     9241 gtgatggggt cgccattgtc gtccttcgcc tccagcaatg ccgtcagcaa atcgtccggc
     9301 ttttgaccgg atgcccggcg ctcggcgacg atctcgtcca ccagaagatg caaatcggcc
     9361 agtgcgcggt cgaatttgcg gttggccgga agcggcagcc gatagagcgg cccggccggg
     9421 atcaccatgc gccggtacat gccccggaac accgtcgtga gcgcgatgct cagccgctcc
     9481 gcccgctcgt ccatgtaatg gccgcgcagc agacaacggg ccgcgatgcg cacggcgacc
     9541 cggaacgact ccgatgtgca gtcgatgatc tcccccggct gccagcgcgc cgcgaacgcc
     9601 cgcgcctcct cctccatgat cggcccgtac tcggggatga tgtcgagccg gaacgcgggc
     9661 tggatcgtcc gccgctgacg ccggtgcgtc ggcccgttgg cggtggcgac cccgtgcttg
     9721 ccgagcagcc cttcgaggga ctcccacagg ggtccgccga tctcgtagtc ggggctcagc
     9781 gcgagctccc cggtgagcgc cggcgtggtg accgcgtaca tcgtcttggg gcccagtttg
     9841 agccggacta tgtcgccgtg gtcgcgcagc tgggccagga agcccagggg gtcgcgcgcc
     9901 agtttccagc cgtggccgag gcccgggatg ccgcccccgg cgaggggcgg gttgcgcagc
     9961 tgtggtgcct ccggtgcttc gggtttcacc gattcgaggg tcatttctca cctgccgctt
    10021 cgttgttgac gtacgggggt gtcgagcggt cgtcccagct gtcgacccgg taccggccgg
    10081 actcgtggtg gaaccagtac acggtgctga accagttccg catattggcg acgcacgcct
    10141 tcacggcgtc gctcaattca tggcccgccc gggttccgtc ggcgaggccg tcggcgaggt
    10201 gcaccgcctc cttttcggcg acgaggaatt ccgcaatgca ttcctccact cgtcgccgga
    10261 cttctgtgac ggcttcttcg agtgtcagtc cctcgtgatg aatgagactg atgccgagat
    10321 tatggacctc gtcacccgcg atttccttgg gaagtgaaca caggtcgttg taccaggcgg
    10381 cgaattcctg gctcagcagc gcggcccgcc gatatccggg gtgttcccgc acgccggccg
    10441 gaatttcgtg gcgcgcactc ggctccagca ggtcggtcca gatccggtgc gcgaaggtga
    10501 gccgccgcag ttcgaggtac tcctcgacgg tggggacgat gccccgggtg cggttgtgga
    10561 actcccggtc gtacgcctcg atcaccgcgt ggaagtggca cgcgaaccgc gcgttccact
    10621 tcttgccgag gaacgagtac agccgcacca tactgtccgc gaacccggcc accaggggat
    10681 cccggtggtg cagatgatcc cggggggagt cgagtgccgt gtgcagctgg aaccggagct
    10741 gccgccaggc ggtggcccga cggtggatga cgtcccggtc gtggcggtcg tcccagacga
    10801 agaaccacgc gctgtagtcc gctatcgcct ggaggacctc gtcgggggcg ccgatgtagt
    10861 agcccgccat gaggtccgtg tagcacagtc cgtcggcata ttcctcgacc ttgtccgccg
    10921 gcatgaggcg cttttccagc agccaggatc gggtcttctc ctgaagccgg ggccaatacg
    10981 gatgcagttg acggggaaaa tccgtctcga tcaccggtag agagagcgcc ggtggaaccg
    11041 cgatcacggt cgttgtcggt gaagtgctgt gtgggaaagc aggcacgaac aaacccctct
    11101 cagccgccag ttggcgctac acccctcccg ccgtgccggg cgcgcgccgt tgcgtatccc
    11161 cgcgcattcc attcagcact acaactgacc gtcctgggaa cggatttact ccagtcacta
    11221 ccctttggtg ccgagaatcc ccccatctgt gactgattat ggatcattca acgagcacaa
    11281 gggatcgaac gtgcgacgca catacgaacg acgcctggtc gggagggccc cggccagacg
    11341 ccgttcgtgc gggacgctca ggccccggct gtcattttct gtctcagtcg ttcgcgacca
    11401 cgctcagccg ttcgcaacct cgctcagtcg ttcgcgacca cggggtagcg gggctcgttc
    11461 tcggccatct gccgcagggc gtccttgcgt tcgcgcttgg agagccggtc gatgtacagg
    11521 tagccgtaca ggtggtccgt ctcgtgctgg aggcagcgcg cgaagtagcc ggtgccccgc
    11581 accttgatcg ggttgccctt ctcgtcctga ccggtgacct cggcgtagtc ggggcgggcg
    11641 agcggcgcgt acgcggtggg cacggagagg cagccctcgt tgctgtcgtc caggcggcgc
    11701 cggtcggcgg gcaggtcgac gagcttgggg ttgcagacca caccgacgtg ccgggtgccc
    11761 tcgtcgtcct ggcagtcgta gacgaagacc ttcaggtcga cgccgatctg gttggcggcc
    11821 aagcccacgc cctcggcggt gcgctggctg gcgaacatgt cggccaccag ctgctccagc
    11881 tcggcgccga agtcggtgac gtccttgcac tccttgtgca gcacggggtt gccgacgacc
    11941 gtgatcggtc gcgaggtgcc gcgctcgcgg taggccgcct cgcgctcctc gcagtcctcg
    12001 gcgtcgatga cgaagccgtc gtcgtccacg gggagcaccc cggtgtgctg ctgatcggtg
    12061 tcctgctgcg ccatgaccga cgtacgcctt cctgcgaatt ccatgagagt ggtgcgcata
    12121 cagcctacgg ggaccggtgg gggccgttca gcagacctct tcgagatccc gccagccgcg
    12181 cgagtccggg ctgtcggcga cccagccgtc gagcaggccg cgcacgaggg cggcgggcgc
    12241 cgcgatgccg cactcccgct cgggcaccca cagctgcccg tcggtgcggt ggccgagggg
    12301 gcccgggtgc cccggttcgc tgtggtcgtg cgggtcgagg tgctcgccgt cgccctcgtc
    12361 ggacggcatc cgggactcgg agcacatacg gcacagcagc cgcacggacg aggaccagtc
    12421 ctcggcggcg aagcccgcgt cggccgcgag ctgctccagt gcgtcccggt cgtcctcggt
    12481 ggccgcttcc agcagcacca cccaggtcgg cacgggcgac ggcgcccaca gctcgatctc
    12541 gtcgaacacg gggtacgcgt gcccggcggc ggtcgtccgc tccccgtgcg gcaccccgtc
    12601 gtgcaggacg acctcgcccc agcgccgccc ggaggagggc agcggaatcg acagcacctc
    12661 gatgcgcgcc ggatccagcc tccgccccca gacgacctcg gcctcgccct cgggcgacag
    12721 gcgtacggcc gcactgccca ggtccatccc gacgggttcg ccggaggcgg tggcgccgcc
    12781 cggcacccgc agcccgtacg cctgccaggc acggcgggcc agcggccagt cctggagggc
    12841 ggtcgcggcg atcccgacgt tccaccagtc aggtgcgccg gtctcgcggt cgaggagcgc
    12901 cacggccctg agcccggccg cccgcgcctg ctcccagtcg tgccggaact tgtgcagcag
    12961 ggccaggttg aaccaggact ccgacagcca cggctccagg tcggccgcac gcgtcagcag
    13021 cgcgcccgcg tcctcgtacc ggccgtcgcc gatcagtgtg aacgcccggt cggtggcctg
    13081 ccgccatgag gcggagggcc ggtgccgtcc cttgccgaag atcctcacga ttcccgcctg
    13141 ccagttcctt gcgcttcccg cctgccggtc ctttgaagtc agtacggcca tgggccggcc
    13201 tgcgcccccg aacacgctct ccctcgcatc caaccacgtc ccgtcggacg ggcgctcatt
    13261 acccatgggt tacccagccg aaggcaaggt cagaccgtct ctcgacagca ctctggccag
    13321 ggattccacg acctccggct gatagtcgcg ggcggtgccc agccgcagtt tctccaaggc
    13381 cgtgagcggc cctccgggac ctgctgcccg aaccatctcc tcgtacgcgt tcacggcccg
    13441 tacgatcctg gcactcaccg gctgctcccg gtacgggtcg gcctgccgct ccaccaccac
    13501 cgccacctcg gcgttcaccc cggtctgccg cacgacggca ccgccgagga gcgcgatgcg
    13561 ccgctgctcg tcggcggaga gcacggcggt ggccccggcg ggcaccggat cgaccaggct
    13621 cagctggccg atgtcgtgca tcagggccgc gtactccagc acggtcagtt ccggcccgga
    13681 caacccgagc tcccgcccga ccgcccggct gagcacggcc acgcgccggg cgtggccggc
    13741 gggggtgcag cccgcgatct cggtcgcgcg tgcgagggag gcgatcgtct gcgtgtatgt
    13801 gacccggacg gccgcgtagc gccggaagga gaactgggtg aggaggagcg gcagggagaa
    13861 gacgggcagg gcccagagac ccacgacggc gacggcgagc gacatcacgg ccccggtcgc
    13921 gcacacggcg gagccgatgc cgagcatggc gcgcagctcg tcgcggagca gggggccgaa
    13981 cggccagcgg gtgcgggagt gtgccatgac cgcggcgagc agcgcgtcgc acagagcggt
    14041 gagcagcagc agggcgacga ggagcagggc gtgggcgggg ccgccccact cgtgcaaccg
    14101 gccccgctcg tagaggggtt ggaagcagag ggcggcgaat ccgacggtga ggacgcggcg
    14161 ggtgaggtgg tcggcggtgg ggccgccccg ggccacgtgg gggacacagc cgaggagggc
    14221 cgcggcgacg acgacggcga cgacctggag ggcgccgtga tgggtcgggt gcccggcgtt
    14281 ctccccgagc agtgcgtagg cgagcgcccc ggccgcgccg agcggcgccg acgcccgttc
    14341 tccggccccg ctccagcggg ccagctcccc cacggcgacg agcagcccga aggcgagggc
    14401 gtcaccgggc cggtcgaccc cgtgccagag ggtgtcggca agggccgcgg cgcccagcag
    14461 cagggcgccc ccgtgggcga ggacgagaac ccgggcaggc cgtccccgga cggcccccgg
    14521 aacgtacgtc tgccgctgcc ctggcagccc ctgcctctcc ggcccctcgg acccctcgga
    14581 cctctccggc ccgctcacgc cccgcccccg ccgacgccgt ttcggtggct ccggctttcc
    14641 agtcggctgg aaacaggtgg ggcgggtggg cagacgcctg gcggtacgtt ctcgtccgcg
    14701 gtcaccgccg gatgccaccc ctgccgcccc aacgcccgca ccaacgcccc caccatcacc
    14761 ggatcgaact gcgcccccgc acaccgctcc agctcctcca gcgccgcggc caccggccgc
    14821 gcccgccggt acgaccgcgt cgacgtcatc gcgtcgaagg cgtccgccac ggccaccacc
    14881 cgggcgaact ccgggatctg ggccccggtc aacccgtacg gatacccgct tccgtccagc
    14941 cgctcatggt gatgcaggat cgcggaccgc gcctccccca ggaacccgat cccgcgcacc
    15001 atctcgtgcc cgtactcggg atgcagctcg atgatccgcc gctcctcggg cgtcaacggc
    15061 ccgtccttgc gcagcagccg cgtgggcacc ccgagtttgc ccacgtcgtg caggatcccg
    15121 gcgaagcgca gcacctcggc gcgctcgtcg tccatgccca gctcgcgcgc gatcatcatc
    15181 gacgcctggc cgacccgctc gctgtgtccg cgggtgtacc cgtccttgat gtcgacggcc
    15241 tgcaccagcg cgcggatcgt ggcctgatgg gcggcccgct cccggtggta ctgcgcgaac
    15301 acccagcagg acacgtacat cggcagcagc acgagcagcg cggccaccgg accgtacgga
    15361 ctgcgccaca gcaccgccat catcagcccg gcaaggccgt gcacggcgac gggtgcgagg
    15421 gagcgcggga acaggccccg ccaggcaccg cgcacgggca cccgctcggc cagggccagg
    15481 atccccccgt cgagcgcggt cagcacggcg cagaacgcca gcacggcggc cccggcgggc
    15541 acgagcgcgt acgggaagtc gggggaggcg accgcggccc gcccgcccag cgccccgtgt
    15601 gcccgggacg ccgcccaggt gcagagggcc agctgggccg cgtgccagat ccggcgcagc
    15661 caccgcggtc gccgctcgac ccgggcgagc agggccccgg gcagcggcac cagtgcggcg
    15721 gccgacggcg gcagcagaaa ggccccggcg agcaggacgg ggaagagggt gcccataccg
    15781 gcgggcaccc ggcggccggc cggccgggag ccgtcccctc cggtgccgcc gctcacctcc
    15841 ccgcgaccgg gccggacgcg gggaaacgtg atctgctcgc agccggcgta gagcccggcg
    15901 agcagcgcga ccacccacca cggaacgcgg acggtcgccg ccggagcgag gcaggccagg
    15961 gcggcgacgg cggtgcagag gacgtacacg cgtccccgtg ccggaaccga ccccatggcc
    16021 cgcacagccc ccatggcgcc cctccccgaa cccgtgcctc gcttgcccgg tcatgcccct
    16081 ttcaggctcc ggagcctaga ggggtggggg tggcgcgggg gccgcaacca gcgaatccgc
    16141 gggtctacga cccgcggatt agcacgttcg ggtgatgaac ccggcgcctg cccgaacggg
    16201 caggcgcgtt cacgactcct ggggtgtcgc cggggcggcg gtcacgtcgt gctcgggcac
    16261 cgtctgtccg gagcggatca gatcgatccg gcccatgacc ttggcacgca ggtcggtcgg
    16321 cacgtcgtcc tggccgcagc agcgcttgac cagcttcttc acggcctgct cgagcccgta
    16381 cttctccagg cacggagagc actcctcgaa atgcacctcg aacttggtgc agtccgagtc
    16441 cggcatctca tggtcgagga actcgtagag atggtcgagg acctcactgc aatccgtctc
    16501 gtgcggctct ccgcagctca tgagcccgag cctttcgctt cgttcgactc tccggcgccg
    16561 gccgggacca gtccgcggtc acgggcgtag tcctcgagca tgccgcgcag ttgacggcgg
    16621 ccccggtgca gccgggacat caccgtaccg atgggtgtcc ccatgatgtc cgcgatctcc
    16681 ttgtacgcaa agccctctac atccgcgaga tagacggcga tgcggaattc ctcggggatc
    16741 gcctgcagcg ctgacttgac gtccgagtcg ggcaggtggt cgagcgcctg cgactccgcg
    16801 gagcgcagac cggtcgacat gtgcgactcg gcgcgtgcca gctgccagtc ctcgatctcc
    16861 tcggccgcgc tgcgctgggg ttcgcgctgc ttcttgcggt acgagttgat gaaggtgttc
    16921 gtcaggatgc ggtacagcca cgccttgagg ttggtgccct cacggaactg gtggaaggac
    16981 gcgtacgcct tcgcgtacgt ctcctgcacc aggtcctcgg catcggccgg gttgcgcgtc
    17041 atgcgcaggg cggccgagta catctggtcg aggaattcga gcgcatcccg ctcgaagcgc
    17101 gcgctgcgct cggcggtcga ctccgtgctc gtgccctggc cctcgggctg ctccgcctgg
    17161 ccgttgtcgg tccctgcgtc ggtcccagtg accggaccca cctcctccag cgatgtggca
    17221 ggaccgaaac cggtcccact cgaatcggag gatagacgac gatccggtcc ggccgccgcc
    17281 cgaatcgggg cggtcttcgc cgcgtgcagc accgaccact ccaggtcacg ggcgctgctt
    17341 cggctcgggc agaaggtcga acccatgcgg cggacttcct ctcgtacgaa cgatgaacac
    17401 tctctgttcg ccacaacagc agtcagccac accgcattcc cgggccctac ccgagtgacg
    17461 cggtccactc cacaacacgg tccgtgatga tcgccagggc ctgctcctgg ccgaggggcg
    17521 cccgtttggg gacggcgaaa ccatgatcgc cgtacggcac ctcgaccagt tcgtatgatc
    17581 cgttcgggaa ctcctccggc ttcccgaacg ggtcgttgcc gccctgcacg acgagtgtgg
    17641 gcaccccggc gccgagcagt tcgtcggcgc gggacttctc gggcttgccg ggcgggtgca
    17701 gcgggaagct gagggcgagg acggcggcgg cgccgagttc cgtcgcggtc cggcaggcgc
    17761 cccgggcacc ggcgctccgc ccgccggcga tcacgggcag cccggccttc gcgaccgccg
    17821 gccacagccc ccgccacccc acatccagcg tcttcggcgc gggcgccacc ttcttcccgg
    17881 ccacccgcca gggctgctcg acgagcgcga cggtcacccc gtgcccgggc agcacccgcg
    17941 cgagcgcctg aagatcacgc gcctcgatgc caccgccggc cccatggctg acggcgagca
    18001 cgaggctggc cttcctcgcc ttgtgccagg tgatgcgcgc cgtacccgcg tcggtctcga
    18061 tgagctcggt gatctccgcc atgtcagaag agtgtgccct cttcgggccc ctccagctcc
    18121 ttgagcagct ccggcccgtt gttgcggaca ttgctgacgg ccgtggagac ggggtacgcg
    18181 cgcatcagcc cggcaggcgg tggggcgagc agctcgcgga ggtcgtcggt gtccgtgcgg
    18241 gccgggtcca gccaggcgtc ccagcggtcc ggggtgagca tcaggggcat gcgcgggtgg
    18301 atgtcggcga gcgcgtacgg cccctcggcc ggggccaccg ccagggggct ggtctccgcc
    18361 tccgtcgtga tcaccgagca cgtcacccac caggcccccg gatggtcgtc gggcagggtc
    18421 ctgtcccgcc agaactcgta gataccggcc atcgcgaaga ccgacccgtc ggcggggagc
    18481 acgaagtacg gctgcttgcg cgggcgcttc ttcctgccct cgacctccag ctcgcgctcc
    18541 tgcgaaccgg tcacccactc gtaataaccg tcggcgggca ggatgcagcg ccgggcggcg
    18601 aaggcgcgcc ggtacgacgg cttctcgtgc acggtctccg cgcgcgcgtt gatcatccgg
    18661 gcgccgccct cgggcgtctt ggaccaggag gggaccaggc cccacttgag cttgcgcagc
    18721 tggcgaaccg gccggcccgg gacggaggaa ctcgtggacg cggtgtcggc gtccttgagg
    18781 gggcggtcga ggacggcgta gacgtccttg gtcggggcca cattgaaatc gggcgccagg
    18841 ctttcctccg gctcccactt ctcgacctca aagactcctg cgagatcctc gggcccacga
    18901 ctcgctgcat accgtccgca catacgtgcc agactgccag gcccacccgc cacccgccca
    18961 ccgctcctca acgattgcgc tacgcgcaag cccctgtcga ctgcctccag agggagccac
    19021 cgcagaacaa tggacagcac cgcatcgacc tcgctgagct cgttgaccga cctctgggac
    19081 caggtcttcg gcagccagcc ggaccccgac ctgtgggtcg tgatcgcgac catggtcgcc
    19141 gcgctcgccg tgatcgtccc gcacaacgtc tggcgcctct cccgcaacgc gatcaccatc
    19201 gcgcacgagg gcggccacgg tctgatcgcg ctgctgaccg gccgcaccct caccggcata
    19261 cggctgcact ccgacaccag cggcctcacg gtcagccgcg gcaagccgca cggcctgggc
    19321 atgatcctga ccgcggccgc gggctacacc gctcccccgc ttctcggcct cggcggcgcc
    19381 gcgctgctcg ccgcgggcca catcaccgcg ctgctgtggc tggccaccgt cctgctgata
    19441 gcgatgctgg tgatgatccg caacgcgtac ggcgcgctga cggtgctgct gacgggcggc
    19501 acgttcgtgg tggtgtcctg gctcgccggt ccccaggtgc aggcggcgtt cgcgtacgcg
    19561 gtggtgtggt tcctgctgat cggcggcgta cgcccggcct tcgaactcca ggccaagcgg
    19621 tcgcgcggca acgcgggcga ctcggacgcg gaccagctgt cccggctgac gcgggtgccg
    19681 gccggactgt ggctgttcct gttccacgcg gtgtccctgt gctcgctgat cggcgggggg
    19741 cgctggctgc tggaggtctg acggtccggc gcgtgtctct ccgcttctcc ggcgcgccgc
    19801 tttccgcccc ttccccctcc ttgcatatat gcacggcacg taccccgggc ctctccacgc
    19861 cctatcaccg cactgtttcg ctcggatttc gccgcttttg atcaagatct gcggtcagtg
    19921 ccagccacta aagtggacgc atgaccgtta accccgcaca caccgccctc tggcccgccc
    19981 cgcacgcgag cggagccgtc gacgcgacgg tccacgtgcc cgggtcgaag tcggtcacca
    20041 accgtgccct cgtcctcgcc gccctcgcct ccgagccggg ttggctgcgc cgcccgctgc
    20101 gctcgcgcga caccctgctg atggcggccg cgctgcgcga gatgggcgtc ggtatcgagg
    20161 aaacggtgtc ctccagctcc tccgtcgggg gcggctcgga cggctccggt gaggcctggc
    20221 gtgtcatccc cgccgcgctg cacggcccgg ccacggtcga cgtcggcaat gccggcaccg
    20281 tgatgcgttt cctgcccccg gtggccgcgc tcgccgacgg ccccatccgc ttcgacggcg
    20341 acccgcgttc gtacgagcgc ccgctgaacg gtgtgatcga cgccctgcgc gccctcggcg
    20401 cccgcatcga cgacgacggc cgcggcgcgc tgccgctgac cgtgcacggc ggcggcgccc
    20461 tggacggcgg gccggtcgcc atcgacgcgt cctcctcgtc gcagttcgtg tcggcgctcc
    20521 tcctgtccgg cccgcgcttc aaccagggcg tcgaggtccg gcacaccggt tcgaccctgc
    20581 cctcgatgcc gcacatccgc atgaccgtcg acatgctgcg cgcggtcggc gcccaggtgg
    20641 acaccccgga gtcgggcggc gaggcgaacg tgtggcgggt gacgccgggc gccctgctcg
    20701 gccgtgacct gaccgtcgag ccggacctct ccaacgccca gccgttcctg gcggcggcgc
    20761 tggtgaccgg cggcaaggtc gtcatccccg actggcccga gcgcaccacg cagcccggcg
    20821 acaagctgcg tgagatcttc accgaaatgg gcggttcctg tgaactgacc gagcaagggc
    20881 tggagttcac cggttcgggt gccgtccacg gcatcgacgt ggacctgagc gaggtcggcg
    20941 agctgacccc gggcatcgcg gcggtcgcgg ccctcgcgga ctccccgtcc accctgcgcg
    21001 gtgtggctca cctccgcctg cacgagacgg accgtctggc cgcgctcacc aaggagatca
    21061 acgagctggg cggcgacgtc accgag
//
