LOCUS       NC_003155              28820 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3743106
            Orig. end                         :: 3771926
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28820
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="21"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..28820
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28820
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:18820]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18820
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(460..894)
                     /db_xref="GeneID:41540069"
                     /gene="sodX"
                     /locus_tag="SAVERM_RS15525"
                     /old_locus_tag="SAV_2987"
                     /old_locus_tag="SAVERM_2987"
     CDS             complement(460..894)
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016485 - protein processing [Evidence
                     IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540069"
                     /gene="sodX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925778.1"
                     /locus_tag="SAVERM_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2987"
                     /old_locus_tag="SAVERM_2987"
                     /product="nickel-type superoxide dismutase maturation
                     protease"
                     /protein_id="WP_010984419.1"
                     /transl_table=11
                     /translation="MPELSQETERGRAVLPFGAAEVTGPSMVPTLQHGDRLLLQYGARV
                     RPGDIVVLRHPFQQDLLVVKRAVERREGGWWVLGDNPYAGGDSTDYGTVPEEFVLGKVR
                     FRYRPRKEGQRSPFALALWALSAARPVLSVRSASRRLRAR"
     gene            1040..1435
                     /db_xref="GeneID:41540070"
                     /gene="sodN"
                     /locus_tag="SAVERM_RS15530"
                     /old_locus_tag="SAV_2988"
                     /old_locus_tag="SAVERM_2988"
     CDS             1040..1435
                     /EC_number="1.15.1.1"
                     /GO_function="GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540070"
                     /gene="sodN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313646.1"
                     /locus_tag="SAVERM_RS15530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2988"
                     /old_locus_tag="SAVERM_2988"
                     /product="superoxide dismutase, Ni"
                     /protein_id="WP_004983535.1"
                     /transl_table=11
                     /translation="MLSRLFAPKVKVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGN
                     DDPHFQARATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKA
                     STDPATGQKALDYIAQIDKIFWETKKA"
     gene            complement(1769..2278)
                     /db_xref="GeneID:41540071"
                     /locus_tag="SAVERM_RS15535"
                     /old_locus_tag="SAV_2989"
                     /old_locus_tag="SAVERM_2989"
     CDS             complement(1769..2278)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540071"
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981999.1"
                     /locus_tag="SAVERM_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2989"
                     /old_locus_tag="SAVERM_2989"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_010984420.1"
                     /transl_table=11
                     /translation="MHDTKNQDVNEELNDELAEKPGEEAHAELDVDAFTTAIENFNRFY
                     IRLPMLEKLSFTTLSVLDTLAFGGSPMRLTDLARTEQVSQPGITQLVTRLERDGLVERR
                     SDPSDGRAVLVHITEAGRKIGRSRHEDRTRHLTPLVAQLAPEQRQAIADALPALARLAE
                     IGRGRP"
     gene            2391..3395
                     /db_xref="GeneID:41540072"
                     /gene="gap"
                     /locus_tag="SAVERM_RS15540"
                     /old_locus_tag="SAV_2990"
                     /old_locus_tag="SAVERM_2990"
     CDS             2391..3395
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0019682 - glyceraldehyde-3-phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540072"
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984421.1"
                     /locus_tag="SAVERM_RS15540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2990"
                     /old_locus_tag="SAVERM_2990"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_010984421.1"
                     /transl_table=11
                     /translation="MTVRVGINGFGRIGRNVFRAAATRGADLEIVAVNDLGDVATMAHL
                     LAYDSILGRFPEEVTAEPGAIRAGDTTVKVLAERDPAALPWGDLGVDVVIESTGIFTDA
                     AKARAHVDGGAKKVIIAAPASNEDVTVVLGVNQDAYDPERHTIISNASCTTNCLGVLAK
                     VLHDAVGIESGMMTTVHAYTQDQNLQDAPHKDLRRARAAGLNIVPTSSGAAKAIGLVLP
                     ELQGRLDAFALRVPVPTGSVTDLTVTASRSTTVEEVKEAYAKAAAGAYKGLLSYTEAPI
                     VSTDIAGDPASCVFDAELTRVLGSQVKVVGWYDNEWGYSNRLIDLALLVGDTL"
     misc_feature    3512..3529
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    3592..3609
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.16"
                     /tool="antismash"
     gene            3756..4613
                     /db_xref="GeneID:41540073"
                     /gene="ptlH"
                     /locus_tag="SAVERM_RS15545"
                     /old_locus_tag="SAV_2991"
                     /old_locus_tag="SAVERM_2991"
     CDS             3756..4613
                     /EC_number="1.14.11.35"
                     /codon_start=1
                     /db_xref="GeneID:41540073"
                     /gene="ptlH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_037648981.1"
                     /locus_tag="SAVERM_RS15545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2991"
                     /old_locus_tag="SAVERM_2991"
                     /product="1-deoxypentalenic acid 11-beta-hydroxylase"
                     /protein_id="WP_037648981.1"
                     /sec_met_domain="PhyH (E-value: 1.1e-19, bitscore: 70.4,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNVTGDYTDCTPLLGDRAALDSFYEEHGYLFLRNVLDRDLVKTV
                     AEQMREGLVALGAADPHATLEELTIDSFESVDEVAMHDYVKYDAFWNNPSTIKVFEQVF
                     GEPVFVFLSTTIRYYPSQAGSEEPSFHYLTPFHQDGFYIGPNQDFRTFWIPLIRTTRES
                     GGVALADGSHRRGKRDHVLNESFRRFGHPVRGIPPTEVSEDEHLLHSPMEPGDILLFHA
                     HMCHKSIPNLSKDPRLMRMSMDTRVQPAKSHRGFNAMTPWTESAKDASKGIMAKITGTP
                     TDVE"
     misc_feature    3846..3848
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4656..4665)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    4718..4732
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 21.15"
                     /tool="antismash"
     gene            4779..6125
                     /db_xref="GeneID:41540074"
                     /locus_tag="SAVERM_RS15550"
                     /old_locus_tag="SAV_2992"
                     /old_locus_tag="SAVERM_2992"
     CDS             4779..6125
                     /codon_start=1
                     /db_xref="GeneID:41540074"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577087.1"
                     /locus_tag="SAVERM_RS15550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2992"
                     /old_locus_tag="SAVERM_2992"
                     /product="MFS transporter"
                     /protein_id="WP_244905198.1"
                     /transl_table=11
                     /translation="MILTGFALSIADFFIVNVALATVKHDLHASDAELELVVSGYGITY
                     ALGLVMGGRLGDAFGRRRLFRDGLIAFTITSALCGFAPNVTFLIAARLLQGAAAAMLVP
                     QVLGTIQAATDGASRARAISLYGATAGIAAVAGQIIGGFLLMLDIGDSGWRSVFMINVP
                     IGLVALLLVRRMPATKADRKPGLDLLGTALFGVTMVCVLMVIVEGRSLGWPVWLWSLLV
                     VAAVAAVTLVRVERGLEARGGSPLLPPSILARHSMRTGLMAVVPFSIGFGSFLFVYTLV
                     AQDKLGLGALASAGVLSPFASSFFVVSLFTPKITARIGRRIVSVGAVVQGTGLLLLALL
                     IGVEWPHLPLLLVLAVLAFTGIGQALIGPTLLRMVLADVPPASAGTGSGVLVTSQQTAT
                     ALGVTVGGTLYLTLASSLGDASGAVLVLVLLALFSAVIFALSLRLPEPR"
     misc_feature    complement(4819..4839)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.04"
                     /tool="antismash"
     gene            6201..7013
                     /db_xref="GeneID:41540075"
                     /gene="ptlF"
                     /locus_tag="SAVERM_RS15555"
                     /old_locus_tag="SAV_2993"
                     /old_locus_tag="SAVERM_2993"
     CDS             6201..7013
                     /EC_number="1.1.1.340"
                     /NRPS_PKS="Domain: PKS_KR (6-173). E-value: 5.3e-13. Score:
                     41.2. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS15555_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GeneID:41540075"
                     /gene="ptlF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984424.1"
                     /locus_tag="SAVERM_RS15555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2993"
                     /old_locus_tag="SAVERM_2993"
                     /product="1-deoxy-11-beta-hydroxypentalenate dehydrogenase"
                     /protein_id="WP_010984424.1"
                     /sec_met_domain="adh_short (E-value: 5.7e-29, bitscore:
                     100.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLQPSTAVVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGA
                     VEELAAHGADVTAVVADLTDPAAVQELADTAFGRLGDIDVVCNNAGVVGPVGMPLWSVP
                     LDEMHAVFDVNYWAHVHVARAFVPRLLDSGRPSHLVQTASMSAFVVGAGTASYAASKHA
                     DLAAARSLRADLDGTPVRVSVLCPGRVDTPMTRGLVAPRNATGNTTISADEAADAVWNA
                     LGSDRFYIFTNADAQTRLGDQFNDVWRHLAREKYWTESSSPSVNSSRP"
     aSDomain        6219..6719
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS15555_PKS_KR.1"
                     /evalue="5.30E-13"
                     /label="SAVERM_RS15555_PKS_KR.1"
                     /locus_tag="SAVERM_RS15555"
                     /protein_end="173"
                     /protein_start="6"
                     /score="41.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGAVEELAA
                     HGADVTAVVADLTDPAAVQELADTAFGRLGDIDVVCNNAGVVGPVGMPLWSVPLDEMHA
                     VFDVNYWAHVHVARAFVPRLLDSGRPSHLVQTASMSAFVVGAGTASYAASKHADLAAAR
                     SLRA"
     CDS_motif       6225..6362
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAVERM_RS15555_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="SAVERM_RS15555"
                     /protein_end="54"
                     /protein_start="8"
                     /score="18.0"
                     /tool="antismash"
                     /translation="VVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGAVEELAAHG
                     A"
     gene            7071..8855
                     /db_xref="GeneID:41540076"
                     /locus_tag="SAVERM_RS15560"
                     /old_locus_tag="SAV_2994"
                     /old_locus_tag="SAVERM_2994"
     CDS             7071..8855
                     /EC_number="1.14.13.170"
                     /EC_number="1.14.13.171"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540076"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000065: Oxidation (100% identity)"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984425.1"
                     /locus_tag="SAVERM_RS15560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2994"
                     /old_locus_tag="SAVERM_2994"
                     /product="neopentalenolactone/pentalenolactone D synthase"
                     /protein_id="WP_010984425.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 8.5e-07, bitscore:
                     27.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDIEAVRAKYREERDKRVQADGGRQYLSAQGEFAHYADDPHAKP
                     IERAPVSDEVDVTIIGAGIGGLLLGARLREACAFDTIRLVDKAGDVGGTWYWNRFPGLR
                     CDVESYVYMPLLEELGRLPSEKYATGAEIFEHCQAIARTYDLYDEALLQTSVTELSWDE
                     DSSRWLVRTDRGDLVRSRFVAMAIGSLHRPKLPSIPGTEAFQGHSFHTSRWDFAYTGGD
                     ISGGLEKLGDKRVGIVGTGATAVQCIPHLAESAAHLYVFQRTPSTVSVRNNRPTDPGWA
                     AGLEPGWQQRRMDNFHALTSGVDQDVDLVQDGWTEITSKLAAILPKSAADADPKDIGTA
                     VELADFHKMEELRKRVDAIVHDKDTADALKPYYRLFCKRPCFHDGYLDTYNRPNVTLVD
                     TQGRGVERLTPTSVVAGGREYPVDCLIFASGYESEFGVPYTNRTGFSIVGRDGIRLSEK
                     WAEGARTFHGLQVNGFPNCFILSKAQSGLHVNVPYMLNEQSKHVAYILKAVQQRGRQVV
                     EASATGEKEWVETILRLANRNLDFTESCTPGLFNNEGNPRNVAILNSSYGGGSVGFVNI
                     LKRWREADDLADLELREG"
     misc_feature    8841..8843
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8868..9776
                     /db_xref="GeneID:41540077"
                     /locus_tag="SAVERM_RS15565"
                     /old_locus_tag="SAV_2995"
                     /old_locus_tag="SAVERM_2995"
     CDS             8868..9776
                     /EC_number="1.14.11.-"
                     /EC_number="1.14.11.36"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: TauD (10-283). E-value: 1.4e-53. Score:
                     174.3. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS15565_TauD.1"
                     /codon_start=1
                     /db_xref="GeneID:41540077"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000063: Dehydration, Oxidation (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182242.1"
                     /locus_tag="SAVERM_RS15565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2995"
                     /old_locus_tag="SAVERM_2995"
                     /product="neopentalenolactone/pentalenolactone F synthase"
                     /protein_id="WP_037648983.1"
                     /sec_met_domain="TauD (E-value: 1.9e-51, bitscore: 174.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDITRIPGSAIGAVVAGADFSGTIDDTQVEEIWQALDQHLVLVFR
                     GHKDPSNDDLLMFARRFGHVPKTGLTTGASPDHNEILLISNILDENGQKIGVGNAEWMD
                     WHTDYSFRPRVSRIGFLAAVELPPSGGGQTLFTDMYTAYESLPDDLRQRLHSYRARHSL
                     RSGYEDVIEEEYQGEVSIEGPTAKPFVAPEDGTATVHQLIARNPRTGRRAVYANPLNTK
                     RILELDVTSSKEVLQQLFAKPGEPELTYAHEWLPGDIVMWDQLGTVHAKRAFDPTERRL
                     LRKVVTIFDDPAEPWHPEDAA"
     aSDomain        8898..9716
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS15565_TauD.1"
                     /evalue="1.40E-53"
                     /label="SAVERM_RS15565_TauD.1"
                     /locus_tag="SAVERM_RS15565"
                     /protein_end="283"
                     /protein_start="10"
                     /score="174.3"
                     /tool="antismash"
                     /translation="IGAVVAGADFSGTIDDTQVEEIWQALDQHLVLVFRGHKDPSNDDL
                     LMFARRFGHVPKTGLTTGASPDHNEILLISNILDENGQKIGVGNAEWMDWHTDYSFRPR
                     VSRIGFLAAVELPPSGGGQTLFTDMYTAYESLPDDLRQRLHSYRARHSLRSGYEDVIEE
                     EYQGEVSIEGPTAKPFVAPEDGTATVHQLIARNPRTGRRAVYANPLNTKRILELDVTSS
                     KEVLQQLFAKPGEPELTYAHEWLPGDIVMWDQLGTVHAKRAFDPTERRLLR"
     gene            9828..10004
                     /db_xref="GeneID:42527440"
                     /locus_tag="SAVERM_RS42725"
                     /old_locus_tag="SAV_2996"
                     /old_locus_tag="SAVERM_2996"
     CDS             9828..10004
                     /codon_start=1
                     /db_xref="GeneID:42527440"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS42725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_2996"
                     /old_locus_tag="SAVERM_2996"
                     /product="hypothetical protein"
                     /protein_id="WP_010984427.1"
                     /transl_table=11
                     /translation="MEQTVRSGNGAAGGILGHSSAGLRNDRHDGALTPGAAPQRSSTVD
                     PVHLVDPVKGVAS"
     misc_feature    complement(9829..9843)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.66"
                     /tool="antismash"
     gene            10001..11014
                     /db_xref="GeneID:41540078"
                     /locus_tag="SAVERM_RS15570"
                     /old_locus_tag="SAV_2997"
                     /old_locus_tag="SAVERM_2997"
     CDS             10001..11014
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540078"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358322.1"
                     /locus_tag="SAVERM_RS15570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2997"
                     /old_locus_tag="SAVERM_2997"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_010984428.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.6e-56, bitscore:
                     189.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTPESLHRSRDAITPALRTALHLLDEETRHQAAYHLGWIEADG
                     TPADGGGGKAVRPALALLSAQAAGAPAETGLPGAVAVELVHNFSLLHDDLMDGDEERRH
                     RRTVWTLWGASGAILTGDALLALAQEVLLDCGLPTGAAAARLLARTTRDLIRGQVQDVA
                     FERRAHVPIEECVDMAAGKTGALLSASAAIGAVLAGAPVTTVDALALYGQQVGLAFQLT
                     DDVLGIWGDPAVTGKSVHSDLRARKKSLPVTYALNQGGTVSVELATWLSAPGEPDEAEL
                     RRAADLVAAAGGRDWATAEAARRMALGEAALRGVDLDAAARDELIALGHFVVDREV"
     gene            11619..12629
                     /db_xref="GeneID:41540079"
                     /locus_tag="SAVERM_RS15575"
                     /old_locus_tag="SAV_2998"
                     /old_locus_tag="SAVERM_2998"
     CDS             11619..12629
                     /EC_number="4.2.3.7"
                     /codon_start=1
                     /db_xref="GeneID:41540079"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984429.1"
                     /locus_tag="SAVERM_RS15575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2998"
                     /old_locus_tag="SAVERM_2998"
                     /product="pentalenene synthase"
                     /protein_id="WP_010984429.1"
                     /sec_met_domain="T1TS (E-value: 6.5e-83, bitscore: 278.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFHIPFPSRRSPDFERARADHLSWPRALGLIGTDAAAERH
                     SRGGYADLAARFYPSATGADLDLGVDLMSWFFLFDDLFDGPRGEDPQETRKLTDAVAAA
                     LDGPLPTSAPPIAHGFADVWRRTCQGMSPAWRARSARHWRNYFSGYVDEAVSRHLNTPY
                     DSAGHYLAMRRQTIGVQPTVDLAERSCHCEVPQRVFDSAVLFAMLQIATDTNLILNDIA
                     SLEKEEARGELNNMVFILMREHGWTRGRSIAHMQDGVRTRLEQFLLLEACLPKVYDTFE
                     LTAQERESAEKYRMDGVRSVIRGSYDWHRSSGRYAADYAIAASYQGYLEELGSTL"
     gene            12686..14035
                     /db_xref="GeneID:41540080"
                     /locus_tag="SAVERM_RS15580"
                     /old_locus_tag="SAV_2999"
                     /old_locus_tag="SAVERM_2999"
     CDS             12686..14035
                     /EC_number="1.14.15.32"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540080"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000064: Oxidation (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984430.1"
                     /locus_tag="SAVERM_RS15580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2999"
                     /old_locus_tag="SAVERM_2999"
                     /product="pentalenene oxygenase"
                     /protein_id="WP_010984430.1"
                     /sec_met_domain="p450 (E-value: 1.5e-79, bitscore: 266.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQHTFVAGTAPGAVPVVGHAWQMMRRPLHFMSSLSAHGDLVKIR
                     IGPTSAYVPCHPELLRQVLTNDRVFDKGGVFYDRARDIAGNGLVTCPYRDHRRQRRLMQ
                     SAFQRTQLERYSTAMRAEIDATAARWHDGTVIDAFPELYGMALRTVARTLYSTPVTEEL
                     AQRVEQAFDTVLNGLFRQMFLPHSLRRLPTPANLRYRNNLRFLHDTVQDLITEYRRDDT
                     QRDDLLSALLASRDEDGGRLGDTEIHDQVITVMAAGTETVAGTLTWIFHLLSRHPEIEA
                     RLYEEIDTVLDGKPPHWDDLPSLSLTDRIITEALRMYPPAWIFTRLTASDVDLAGVRLP
                     EGTTIVFSPSSVQRHSEAYDDASRFDPDRWLPDRTSAVARQAFTAFGTGARKCIGDLFA
                     RTEATLALATMLSQWRVTVEPDADVRPVALATVYHPRRLRLRLTARTPGQ"
     gene            14095..14556
                     /db_xref="GeneID:41540081"
                     /locus_tag="SAVERM_RS15585"
                     /old_locus_tag="SAV_3000"
                     /old_locus_tag="SAVERM_3000"
     CDS             14095..14556
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540081"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353600.1"
                     /locus_tag="SAVERM_RS15585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3000"
                     /old_locus_tag="SAVERM_3000"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_010984431.1"
                     /transl_table=11
                     /translation="MANLEDLVRLRKARDRMDREYAEQLDIAALARTALMSPGHFQRSF
                     RAAFGETPYSYLMTRRIERAKALLRRGDLTVTEVCLAVGCTSLGSFSSRFTELVGETPS
                     AYRARSHEHGAPIPPCVAKGLTRPRRGRPVYGRADTAGGTWTTGPSVTS"
     gene            14559..14987
                     /db_xref="GeneID:41540082"
                     /locus_tag="SAVERM_RS15590"
                     /old_locus_tag="SAV_3001"
                     /old_locus_tag="SAVERM_3001"
     CDS             14559..14987
                     /codon_start=1
                     /db_xref="GeneID:41540082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925788.1"
                     /locus_tag="SAVERM_RS15590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3001"
                     /old_locus_tag="SAVERM_3001"
                     /product="VOC family protein"
                     /protein_id="WP_042493119.1"
                     /transl_table=11
                     /translation="MDTDPGVMLSQCFIAVDDHDKALAFYRDVLGLEVRNDVGFEGMRW
                     VTVGSPLQPDVEIVLEPPGANPDASEADRQAMAELLAKGMLRGVIFSTPDCDALFARVE
                     ASGAEVLQEPMDQPYGVRDCAFRDPAGNLLRFKQRSAA"
     gene            15090..15827
                     /db_xref="GeneID:41540083"
                     /locus_tag="SAVERM_RS15595"
                     /old_locus_tag="SAV_3002"
                     /old_locus_tag="SAVERM_3002"
     CDS             15090..15827
                     /codon_start=1
                     /db_xref="GeneID:41540083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000782.1"
                     /locus_tag="SAVERM_RS15595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3002"
                     /old_locus_tag="SAVERM_3002"
                     /product="VOC family protein"
                     /protein_id="WP_037648985.1"
                     /transl_table=11
                     /translation="MSEPIRWAYAFVDRPAAEFVRAVDFWTAVTATERSESRGDQGEFV
                     SLLPGAGDACVKAQGVRDGTGGAHLDLAVANVPALVGAARRLGAEVVAEHPGWAVLRSP
                     GGQLFCAVPWHGESARPPVVEGSRLDQLCIDLAPAVYDLDVAFWSDLTGWTSHPGALPE
                     FHLVRPPEGLPIRILLQRLGTDRPTSAHLDLACADIEATRVRHEELGATLVARGARWTV
                     LRDPAGGTYCLTARDPETGSLPA"
     gene            complement(15831..16121)
                     /db_xref="GeneID:43933263"
                     /locus_tag="SAVERM_RS43055"
     CDS             complement(15831..16121)
                     /codon_start=1
                     /db_xref="GeneID:43933263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384637.1"
                     /locus_tag="SAVERM_RS43055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_037648987.1"
                     /transl_table=11
                     /translation="MSGVEGGPGEDDGRAAPQRGRRRVWRWAIGVWAAAVLVGGGLTLW
                     LQDSTEPPPPTGWEPAPAPLLSADVRDHPPCPGASDGQAVLCVYATADPDR"
     gene            complement(16118..16465)
                     /db_xref="GeneID:41540085"
                     /locus_tag="SAVERM_RS15605"
                     /old_locus_tag="SAV_3003"
                     /old_locus_tag="SAVERM_3003"
     CDS             complement(16118..16465)
                     /codon_start=1
                     /db_xref="GeneID:41540085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492108.1"
                     /locus_tag="SAVERM_RS15605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3003"
                     /old_locus_tag="SAVERM_3003"
                     /product="DUF952 domain-containing protein"
                     /protein_id="WP_010984434.1"
                     /transl_table=11
                     /translation="MSEPLLHLTERSLWDAARDRGTYEMATRGRTLQEEGFIHCSLRHQ
                     LPGVAALLYGSRAGSDELVVLVVDAERLAAPVRYEAVGPGGEEFPHVYGPIPVSAVVDV
                     EVWTGGEAASA"
     gene            complement(16561..16776)
                     /db_xref="GeneID:91294834"
                     /locus_tag="SAVERM_RS44750"
                     /old_locus_tag="SAV_3004"
                     /old_locus_tag="SAVERM_3004"
     CDS             complement(16561..16776)
                     /codon_start=1
                     /db_xref="GeneID:91294834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973717.1"
                     /locus_tag="SAVERM_RS44750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3004"
                     /old_locus_tag="SAVERM_3004"
                     /product="hypothetical protein"
                     /protein_id="WP_010984435.1"
                     /transl_table=11
                     /translation="MGSDEYACPSCGQPVGTVVRRHKTLGAFVPVWGPAPCRNPRCTAY
                     VPGGGAAAERPGPPEAPPEAPAAKAP"
     gene            complement(16824..17414)
                     /db_xref="GeneID:41540086"
                     /locus_tag="SAVERM_RS15610"
                     /old_locus_tag="SAV_3005"
                     /old_locus_tag="SAVERM_3005"
     CDS             complement(16824..17414)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973719.1"
                     /locus_tag="SAVERM_RS15610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3005"
                     /old_locus_tag="SAVERM_3005"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_010984436.1"
                     /transl_table=11
                     /translation="MGVAIRTAGEGDREAVVRLLDEAFQHDPVSSWVFPGEAYRRATHH
                     RLMAAFTDIVLGEGRVDLTEDGTACALWLSLPADAHDEEDGPARLREAVDPDNDRVELI
                     GRLTSGIHPSGRAHAYLWMIAVAPGRQGEGLGTALMQPVLDRCDRAGLPAYLEASSARS
                     RKLYERLGFVSTTPALDLPDGPRMWPMWREPRS"
     gene            complement(17636..18820)
                     /db_xref="GeneID:41540087"
                     /locus_tag="SAVERM_RS15615"
                     /old_locus_tag="SAV_3006"
                     /old_locus_tag="SAVERM_3006"
     CDS             complement(17636..18820)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540087"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480398.1"
                     /locus_tag="SAVERM_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3006"
                     /old_locus_tag="SAVERM_3006"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_010984437.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.4e-62, bitscore:
                     208.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFLTEAKQSPAEVLERRSPAGPAGRRGPLPAPSTGRQAPAASP
                     PTDPQGPAAQLDGQEAAGILERARASVDPELRRAVDSLPGSMRRIALHHFGWEHADGTP
                     AAGNAGKAIRPALVLAAVRALGGPQSSAVRAAAAVELIHNFTLLHDDVMDRDTTRRHRP
                     TAWTVFGDADAILAGDALQALAHRLLAEDPHPASAAAAARLAACVIELCAGQHADTAME
                     RRGPGEVTLDECLAMAEAKTGALLGCACALGALYAGAEEEDVEALDAFGREAGLAFQLI
                     DDVIGIWGDPSRTGKPAGADLMARKKSLPVVAALAAGTPAAAELAELYAVPHQEGELER
                     TVLAVERAGGRDWAQQQAADRMARAMHELSRAIPDPEAAGGLLALAEFVTRRSN"
     misc_feature    18896..18911
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 28.92"
                     /tool="antismash"
     misc_feature    18896..18912
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.5"
                     /tool="antismash"
     gene            complement(18957..20363)
                     /db_xref="GeneID:41540088"
                     /locus_tag="SAVERM_RS15620"
                     /old_locus_tag="SAV_3007"
                     /old_locus_tag="SAVERM_3007"
     CDS             complement(18957..20363)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136651.1"
                     /locus_tag="SAVERM_RS15620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3007"
                     /old_locus_tag="SAVERM_3007"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_010984438.1"
                     /transl_table=11
                     /translation="MSVGEEVRAEQGRPQQSLGTSAARNLATTTKSAPQMQEISSRWLL
                     RMLPWVNVQGGTYRVNRRLSYSVGDGRVTFVKTGDRVQVIPAELGELTLLRTYEDQEVL
                     GELAQRCEQREFAPGEVLASFGSRADEVFLLAHGKVEKVGTGPYGDDAVLGVLADGAYF
                     GEQALIDPEAIWEYTARAVTACTVLTLPRRDVDQVAERAESLRDHLQQARAIPEQRTNK
                     YGEKEIDLAAGHTGEPDIPGTFVDYEATPREYELSIAQTVLRLHTRVADLYNQPMNQTE
                     QQLRLTVEALKERQEHELINNREFGLLNNCEYDQRLQPHDGVPGPDDLDELLSRRRGSK
                     LFLAHPRAISAFGRECNRRGLVPESVEIAGNRIPTWRGVPIFPCNKIPVSDTRTTSIIC
                     MRTGEDEQGVVGLQQAGIPDEIEPSLSVRFMGINEQAIISYLVTAYYSAAVLVPDALGI
                     LENVEIGRWR"
     gene            20658..20891
                     /db_xref="GeneID:41540089"
                     /locus_tag="SAVERM_RS15625"
     CDS             20658..20891
                     /codon_start=1
                     /db_xref="GeneID:41540089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535203.1"
                     /locus_tag="SAVERM_RS15625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_037648990.1"
                     /transl_table=11
                     /translation="MAGFLDRAKEQAQRGLTQGRQKLDEVQAQRAGGDLLKKLGAAYYA
                     ERRGSGSPGATQQALQALESHIAVNGDAFLHS"
     gene            21061..21651
                     /db_xref="GeneID:41540090"
                     /locus_tag="SAVERM_RS15630"
                     /old_locus_tag="SAV_3008"
                     /old_locus_tag="SAVERM_3008"
     CDS             21061..21651
                     /codon_start=1
                     /db_xref="GeneID:41540090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380968.1"
                     /locus_tag="SAVERM_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3008"
                     /old_locus_tag="SAVERM_3008"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_037648992.1"
                     /transl_table=11
                     /translation="MAPPMSAGSFLDRLREEGVTVVEVGDWEHHNRNHKGPWGPVHGVM
                     IHHTVTSGSEHTVELCRDGYEGLPGPLCHGVITKDGVVHLVGYGRANHAGLGDDDVLRA
                     VIAEKALPPDNEANTDGNRHFYGFECENLGDGTDPWPDAQLEAIEKVSAAICRHHGWSE
                     RSVIGHLEWQPGKVDPRGFTMTWLRERIRDRLK"
     gene            21698..22615
                     /db_xref="GeneID:41540091"
                     /locus_tag="SAVERM_RS15635"
                     /old_locus_tag="SAV_3009"
                     /old_locus_tag="SAVERM_3009"
     CDS             21698..22615
                     /codon_start=1
                     /db_xref="GeneID:41540091"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047522.1"
                     /locus_tag="SAVERM_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3009"
                     /old_locus_tag="SAVERM_3009"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_037648994.1"
                     /sec_met_domain="PALP (E-value: 1.2e-18, bitscore: 66.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPDVPEALDLAALRPRLPSPVQAVDDERFARHGVRLLLKRDDL
                     IHPDLIGNKWRKLAPNLRAAAGRPLVTFGGAYSNHLRATAAAGRLLGLATIGVVRGQEL
                     ADRPLNPSLTRCAADGMRLHFVDRSTYRRKTEPGTLAAILRAVAAEDAYVVPEGGSNSP
                     AVRGCRALGEELRGHADVVALACGTGGTLAGLAAGLGPGQRALGVPVLKGDFLTAEVTA
                     LQERAFGGRQGAWSLDDRFHFGGYARTSPGLHAFAADFERRHGLPVERLYVAKMLYGLV
                     ALAEEGGFARGTTVAAVITGRPLG"
     gene            complement(22622..24223)
                     /db_xref="GeneID:41540092"
                     /locus_tag="SAVERM_RS15640"
                     /old_locus_tag="SAV_3010"
                     /old_locus_tag="SAVERM_3010"
     CDS             complement(22622..24223)
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000788.1"
                     /locus_tag="SAVERM_RS15640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3010"
                     /old_locus_tag="SAVERM_3010"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_010984441.1"
                     /transl_table=11
                     /translation="MDVLPLLLLVAGSAAVAGAARRTPVPAPLLLVAAGLIASYIPGVP
                     EYTLDPEVVLPLVLPPLLYTAASDSSYLDLRAQLRPVALLSIGYVLFATLVVGWAAYLL
                     VPGLPLPAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAYKVA
                     LAAAVGEGATWAHGVGEFLLAAVGGVAVGLLLMVPLHWLRTHLKEALLQNTLSLLIPFV
                     AYGLAEWAHASGVLAVVVVALYLGHRNYEVDFATRLQEEAVWKMVAFVLESAVFALIGL
                     QLQVVLKGLGEYRGVDAAWYAVAVFLVVVLARFVWVYPATFLPRLLSARIREREENPTW
                     KAPFIIGWAGMRGVVSLAIAFSIPLTVHGQGKGPFPGRNLILFLTFTTVIGTLVVQGLT
                     LPPLIRLLRLPGRDAQAETLAEANAQAQASRVAELRLNDLLDDERNALPPPLADRLRDV
                     LERRRNAVWERLGAVNPVTGESVDDTYRRLSREMIAAERSVFVRLRNGRYIDDEMLRTL
                     LRRLDLEEAAAFREAT"
     gene            24285..24545
                     /db_xref="GeneID:41544812"
                     /locus_tag="SAVERM_RS40095"
                     /old_locus_tag="SAV_3011"
                     /old_locus_tag="SAVERM_3011"
     CDS             24285..24545
                     /codon_start=1
                     /db_xref="GeneID:41544812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571357.1"
                     /locus_tag="SAVERM_RS40095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3011"
                     /old_locus_tag="SAVERM_3011"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_010984442.1"
                     /transl_table=11
                     /translation="MKQCTHADALPHPEPEPLSETCPECLATGTHPVQLRLCLVCGHVG
                     CCDSSPRRHATEHHKETGHPVMRTFEPGESWRWCFVDHVLV"
     misc_feature    complement(24674..24687)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.89"
                     /tool="antismash"
     gene            24818..25231
                     /db_xref="GeneID:41540093"
                     /locus_tag="SAVERM_RS15645"
                     /old_locus_tag="SAV_3012"
                     /old_locus_tag="SAVERM_3012"
     CDS             24818..25231
                     /codon_start=1
                     /db_xref="GeneID:41540093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966375.1"
                     /locus_tag="SAVERM_RS15645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3012"
                     /old_locus_tag="SAVERM_3012"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_010984443.1"
                     /transl_table=11
                     /translation="MSQIDGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWTV
                     LSALAGKVSSAVADDKTVSISLYKQRGAGPGPA"
     gene            25249..26403
                     /db_xref="GeneID:41540094"
                     /locus_tag="SAVERM_RS15650"
                     /old_locus_tag="SAV_3013"
                     /old_locus_tag="SAVERM_3013"
     CDS             25249..26403
                     /codon_start=1
                     /db_xref="GeneID:41540094"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136656.1"
                     /locus_tag="SAVERM_RS15650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3013"
                     /old_locus_tag="SAVERM_3013"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_078234443.1"
                     /transl_table=11
                     /translation="MQDEERGTRELPTEDGGAPCSIGADSLGGGGPSGPRRTADGIDGI
                     PEQARPHPEDHSSAAAEGSQQQEPFGEGGRAARSVPVDGRRDPAGARGEALRTESGGAS
                     SKGRRVTGGTMSEHERNAEPSVPSGTQHDPQDRSGARALFIELRMLPDGSPEYAELRNR
                     LVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPERGVEFSTYATPTVVG
                     EIKRHFRDKGWAVRVPRRLQELRLALTTATAELSQQHGRSPTVHELAEKLAISEEEVLE
                     GLESANAYSTLSLDVPDTDDESPAVADTLGAEDEALEGVEYRESLKPLLEDLPPREKRI
                     LLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLREKLLVEE"
     gene            complement(26457..26906)
                     /db_xref="GeneID:41540095"
                     /locus_tag="SAVERM_RS15655"
                     /old_locus_tag="SAV_3014"
                     /old_locus_tag="SAVERM_3014"
     CDS             complement(26457..26906)
                     /codon_start=1
                     /db_xref="GeneID:41540095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384624.1"
                     /locus_tag="SAVERM_RS15655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3014"
                     /old_locus_tag="SAVERM_3014"
                     /product="hypothetical protein"
                     /protein_id="WP_037648996.1"
                     /transl_table=11
                     /translation="MSAEQNRVPDTSDAEPRPGRLTAAAALAALEGLALAAGGVWMLVR
                     GVTGDPDDRQQAVTGGITLLVLALLPLLAARGLLLRRGWSRGPAIITQIMALPVAYSLL
                     QADSIAIPAGIALAAVAVTALVLLVNPATTRALGIRRPGNVQDEK"
     gene            27044..28012
                     /db_xref="GeneID:41540096"
                     /locus_tag="SAVERM_RS15660"
                     /old_locus_tag="SAV_3015"
                     /old_locus_tag="SAVERM_3015"
     CDS             27044..28012
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127486.1"
                     /locus_tag="SAVERM_RS15660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3015"
                     /old_locus_tag="SAVERM_3015"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_010984446.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD
                     LGRQAADSEDIELVVALGGDGTVNEVVNGLLHRGPDPEHLPRLAVVPGGSTNVFARALG
                     LPNDAVEATGALLDALREKRERTVGLGLAAGTPGTEDEAVPSRWFTFNAGLGFDAGVVG
                     RVEQHRERGRRSTHSLYLRQAIRQFLDEPHRRHGTITLERPGAAPVTDLVLSLICNTSP
                     WTFLGNRPVYASPKASFDTGLDILGLSRMSTASVARYATQLLTSSPERGPHGKHAVSLH
                     DLTDFTLHSKAPLPLQMDGDHLGLRTSVTFTGVRRALRVIV"
     misc_feature    complement(28102..28111)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(28273..28288)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    28276..28287
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            28332..28589
                     /db_xref="GeneID:41540097"
                     /locus_tag="SAVERM_RS15665"
                     /old_locus_tag="SAV_3016"
                     /old_locus_tag="SAVERM_3016"
     CDS             28332..28589
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41540097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563321.1"
                     /locus_tag="SAVERM_RS15665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_3016"
                     /old_locus_tag="SAVERM_3016"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_006380970.1"
                     /transl_table=11
                     /translation="MDWRHNAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQ
                     CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQATA"
ORIGIN
        1 gctcacctcg gtggaggccg tccgcgacct cttcgggggc aacgcgtcgg cggcccggcg
       61 cgctacggac gcggacgtga cgcggttccg ttcggtccgc gcgcgcctgc gcgcggtctt
      121 cgaggcggcc gacggcggcg acgagacgct cgccgtcgac ctgctgaact cgctgctgct
      181 ggaattcccg gtgagcccgc agatctcggg ccatgaccac cgggacgacg acgggcgccc
      241 gttgtggcac atgcacctgg ccgaccaccc gtccaacgcg accgcgggct acgcggcgat
      301 cgccacgatg ggcctcgcgt tccacctcac cgagtacggc gtggaccgcc tcggcctgtg
      361 cgaggcggcg ccgtgccgca acgcctatct ggacacctcg acgaaccgct cccggcgcta
      421 ctgctcggac cgctgcgcca cccgcgcgaa cgtggccgcc taccgggccc gcaagcgcct
      481 ggaggcggac cggacggaga gcacgggccg ggcggccgag agcgcccaga gcgcgagcgc
      541 gaacggcgag cgctgaccct ccttgcgcgg ccggtaccgg aaccgcacct tcccgaggac
      601 gaattcctcg ggaacggtgc cgtagtcggt gctgtccccg cccgcgtagg ggttgtcccc
      661 gagcacccac cagccgccct cgcgccgctc cacggcccgc ttcacgacga gcagatcctg
      721 ctggaaggga tgccgcagca cgacgatgtc gccgggcctg acgcgcgccc cgtactgaag
      781 tagcagccga tccccgtgct gaagcgtggg gaccatcgac ggtcccgtca cctcggccgc
      841 cccgaacggc agcacggccc tcccacgctc ggtctcctgc gacagctccg gcatcaccgg
      901 cacctccccg gtccgatcct ccaccagtcc cagtttcacc ctggactttt gtcgtaagcc
      961 catgggggca ctcgcgaaaa gacgtctcct acggagtaat gtcccacctg agaagacgat
     1021 cacgaggaag gacagctcaa tgctctcccg cctgtttgcc cccaaggtca aggtcagcgc
     1081 gcactgcgac ctgccctgcg gtgtgtacga cccggcccag gcccgcatcg aggcggagtc
     1141 ggtgaaggcc gtccaggaaa agatggccgg caacgacgac ccgcacttcc aggctcgcgc
     1201 cacggtcatc aaggagcagc gcgccgagct cgccaagcac cacgtgtcgg tgctctggag
     1261 cgactacttc aagcccccgc acttcgagaa gtacccggag ctgcaccagc tggtcaacga
     1321 caccctgaag gccctctcgg ccgccaaggc gtccacggac ccggccacgg gccagaaggc
     1381 gctggactac atcgcccaga tcgacaagat cttctgggag accaagaagg cctgatcctg
     1441 gatcaagccg tttgacccgc gaccctgtcg gtcgctcggt cttcctgccc gcacccggcc
     1501 cgtgggccgc cgaacacggc ggccgtgacg gtccgggtgc ggtctttttt gtctcgactt
     1561 cgacgtcacg gatccggcgt cacggatccg gcgtcacgga tccgacgtca cacacccggc
     1621 gcctcggacc cgacgtcaca cacccggcat cacgcacccg acgccacaca cccggcatca
     1681 cggatccggc gcctcggacc cggcgtcacg gacccgacgc ctcgacaccg aggtccctgt
     1741 ccgagtgcga cgtctccccc gggcgcccct agggtcggcc ccgtccgatt tccgccaggc
     1801 gggccagggc cggcagggcg tcggcgatcg cctggcgctg ttcgggggcc agttgggcca
     1861 ccagcggggt gaggtgccgc gtccggtcct cgtggcgcga gcggccgatc ttgcggcccg
     1921 cctcggtgat gtggacgagg acggcgcggc cgtcgctcgg gtcggaccgg cgctccacca
     1981 gcccgtcgcg ctccagccgg gtgaccagct gcgtgatgcc gggctggctg acctgctcgg
     2041 tcctggccag atcggtcagc cgcatcgggc tgccgccgaa cgcgagggtg tccagcaccg
     2101 acagcgtcgt gaaggacagc ttctccagca tcgggagccg gatgtagaag cggttgaagt
     2161 tctcgatcgc cgtggtgaac gcgtccacgt ccagctcggc gtgcgcctct tcgcccggct
     2221 tttcggcgag ctcgtcgttg agctcttcgt tcacatcttg gttcttggtg tcgtgcaccc
     2281 cagaaatata tcgtgaactt atgtaagctg cttatgctgt tgcggcggat gccccgtgtg
     2341 ccgccacccg cggggcgcgt catacctggt cagcgctagg agagggatcc atgactgttc
     2401 gtgtcggcat caatggcttc gggcggatcg gacgcaacgt cttccgcgcg gcagccaccc
     2461 ggggcgcgga tctggagatc gtcgccgtca acgatctcgg cgacgtggcg accatggccc
     2521 atctgctggc ctacgactcg atcctgggcc gcttcccgga ggaggtcacc gcggaacccg
     2581 gtgcgatccg cgccggcgac accaccgtca aggttctcgc cgagcgcgac cccgccgccc
     2641 tgccctgggg cgacctgggc gtggacgtgg tcatcgagtc caccggcatc ttcacggacg
     2701 cggccaaggc ccgcgcgcac gtggacggcg gcgccaagaa ggtcatcatc gcggccccgg
     2761 ccagcaacga ggacgtcacg gtcgtgctcg gcgtgaacca ggacgcctac gacccggagc
     2821 gccacacgat catctccaac gcctcgtgca ccaccaactg cctcggcgta ctggccaagg
     2881 tgctgcacga cgccgtgggc atcgagtccg gcatgatgac cacggtccac gcctacaccc
     2941 aggaccagaa cctccaggac gccccgcaca aggacctgcg ccgtgcccgg gccgcgggcc
     3001 tcaacatcgt gcccacctcc agcggagccg ccaaggccat cggcctggtg ctgcccgaac
     3061 tccagggccg cctcgacgcc ttcgccctgc gggtccccgt ccccaccggc tcggtcaccg
     3121 acctgacggt caccgccagc cgcagcacca cggtggaaga ggtcaaggag gcgtacgcca
     3181 aggccgccgc cggcgcgtac aagggtctgt tgtcctacac cgaggccccc atcgtcagca
     3241 ccgacatcgc gggggacccc gcctcctgcg tcttcgacgc cgagctgacc cgcgtactgg
     3301 gctcccaggt caaggtcgtc ggctggtacg acaacgagtg gggctactcc aaccgcctca
     3361 tcgacctggc cctgctggtc ggcgacaccc tctgacggca gcggcaacga cggagtccgg
     3421 cgggcaacga cgccccgccg gactccgcat gtgtgcggcc gcttcccggg tgaattcaac
     3481 catgcatttc aggcctttta tgcagagcgt gtattcacta ctgccgatat cagccgccgg
     3541 ccgtgcacac aaaggagagc cggtcatcac acatgggcgc ggcaacggtt ctggttaaat
     3601 cctggtgaac gaaagtctcc acatgcacga attcaagcca gtcggccgga accggcacac
     3661 tatatccgca aatcgttatg gcattgcgcc cccaatgcgc ggtagtgttt gattgcagta
     3721 ccacggccac tgaggtctca caaggagatg aatctgtgac gaacgtgact ggggactaca
     3781 cggactgcac tcctctgctc ggcgaccgag cggcactcga cagcttctac gaggaacacg
     3841 gctacttatt cctgcggaac gtactcgacc gtgacctcgt caaaacggtg gcggagcaga
     3901 tgcgggaagg actcgtcgcg ctcggtgccg cggatccgca cgccacgctc gaggaactca
     3961 cgatcgactc cttcgagtcg gtcgacgaag tggccatgca cgactacgtc aaatacgacg
     4021 cattctggaa caacccgtcg accatcaagg ttttcgagca ggtgttcggc gagccggtat
     4081 tcgtgttcct ctccacgacc atccggtact acccgtcgca ggcgggctcc gaggagccgt
     4141 ccttccacta cctgacgccg tttcaccagg acggcttcta catagggccc aaccaggact
     4201 ttcgcacctt ctggatcccc ctgatacgga cgaccaggga gtccggaggt gtcgcgctgg
     4261 cggacggcag ccaccggcgc ggaaagcgcg accacgtgct caacgagtcc ttccgcaggt
     4321 tcggccaccc ggtgcgcgga attccgccga cggaggtgag tgaggacgaa cacctgctgc
     4381 actcccccat ggagccggga gacatcctcc tctttcatgc gcacatgtgc cacaaatcaa
     4441 ttccgaacct gtcgaaggac ccgcgcctca tgcggatgtc gatggacacc cgggtacagc
     4501 ccgcgaaatc ccaccgcggc ttcaacgcaa tgacgccctg gacggaatcg gcaaaggacg
     4561 cgtcaaaggg aatcatggcg aagatcaccg gtacccccac cgacgtggaa tgacgaccaa
     4621 cccccacccg gagattttcc ccggcgggcg tcgattcgaa aaacagaggt atggatttga
     4681 cttcagagac gtcgcccgca ggtggcccgg tggaaaagga agatctggtc cgccagggca
     4741 gtgacaaacc agcgggatta tcgggcgccg gcctggcagt gatcctgacg ggcttcgcgc
     4801 tgtccatcgc cgacttcttc atcgtcaacg tggcgctggc cacggtgaaa cacgacctcc
     4861 acgcatccga tgccgagctg gagctggtcg tgtccggcta cggaatcacc tatgcgctcg
     4921 gcctggtcat gggcgggcgt ctgggagacg cgttcggcag acgacgtctc ttccgtgacg
     4981 gcctgatcgc gttcacgatc acgtcggcac tgtgcggctt cgcgccgaac gtcaccttcc
     5041 tcatcgccgc ccgtctgttg cagggcgcgg ccgccgcgat gctcgtaccg caggtgctgg
     5101 gcaccatcca ggcggcgacc gacggcgcgt cccgcgcccg ggcgatcagc ctctacggcg
     5161 ccaccgccgg gatcgcggcg gtggccggac agatcatcgg cggattcctg ctgatgctcg
     5221 acatcggcga ctccggctgg cgatccgtgt tcatgatcaa tgtgccgatc ggtctggtgg
     5281 cgctgctgct ggtccggcgc atgcccgcca ccaaggcgga ccggaaaccg ggcctcgacc
     5341 tgctcggcac ggccctgttc ggggtgacca tggtctgcgt gctgatggtg atcgtcgagg
     5401 gcaggtcgct cggctggccg gtctggctgt ggtcactgct ggtggtcgcc gccgtcgcgg
     5461 ccgtgactct ggtcagggtc gagcgcgggc tggaggcccg gggcggttca ccgttgcttc
     5521 ccccctcgat cctggcccgc cacagcatgc gcacggggct gatggcggtc gtgcccttct
     5581 ccatcgggtt cggcagcttc ctgttcgtct acaccctggt cgcgcaggac aagctgggcc
     5641 tcggggcgct ggcctcggcc ggcgtgctgt ccccgttcgc ctcgtccttc ttcgtggtct
     5701 cgctgttcac cccgaagatc acggcccgta tcggccggcg catcgtgtcg gtgggcgcgg
     5761 tcgtccaggg cacgggcctg ctgctgctcg ccctcctgat cggagtggag tggccgcatc
     5821 tgccgctcct gctggtcctg gcggtgctcg ccttcaccgg catcggccag gctctgatcg
     5881 gaccgacact gctgaggatg gtgctcgccg acgtaccccc cgcgtcggcg ggcaccggca
     5941 gtggagtgct ggtcaccagc cagcagacgg caacggccct gggcgtcacg gtcggcggga
     6001 ccctctacct caccctcgcg agctcgctcg gcgacgcgtc cggggcggtg ctcgtcctcg
     6061 ttctgctggc cctgttctcc gcggtcatct tcgccctgag cctgcggctg cccgagccgc
     6121 gctagccgac agccgctgcc cgagccgcgc cggccgacag acgcggaaga accgctcgcc
     6181 gacacacgtg gagaagctgc atgcaccttc aaccgagtac ggccgtcgtg accggcgcgg
     6241 cgagtggcat cggtttcgcg ctcagcgccc gactggcaca agcgggcgcc agggtcgtga
     6301 tgacggacat cgcgggtgac ggcctggccg gggccgtcga ggagctggcc gcgcacggcg
     6361 cggacgtcac cgccgtggtc gccgacctca ccgacccggc cgcggttcag gagctggccg
     6421 acacggcctt cgggcggctc ggcgacatcg acgtggtctg caacaacgca ggcgtcgtcg
     6481 gaccggtcgg aatgccgctg tggagcgttc ccctggacga gatgcacgct gtcttcgacg
     6541 tcaactactg ggcgcacgtc catgtcgcgc gggccttcgt gccgcgcctc ctcgacagcg
     6601 ggcgcccctc gcacctcgtg cagaccgcct cgatgtccgc gttcgtcgtc ggcgcgggta
     6661 ccgcgtcgta cgccgcgtcc aagcatgcgg acctggccgc ggcccgaagc cttcgggcgg
     6721 acctcgacgg cactcccgtg cgggtctcgg ttctctgccc ggggcgggtc gacacaccga
     6781 tgacccgggg tcttgtcgct ccccggaacg cgaccgggaa cacgacgatc agcgcggacg
     6841 aagcggccga cgcggtgtgg aacgcgctgg gctcggaccg cttctacata ttcaccaacg
     6901 ccgatgccca aaccaggctc ggcgatcaat tcaacgacgt atggcgccat ctggcacggg
     6961 aaaagtactg gaccgaatcc tcttcaccga gcgttaacag ttctcgccca tgaccaccgg
     7021 gtttcgcggg cagaaaccca ccgcaccgat atctttatga gggagatacc gtggtggata
     7081 tcgaggcagt gagagcgaag taccgggagg aacgcgacaa gcgcgtgcag gccgatggtg
     7141 gccgacagta cctgagtgcg cagggggaat tcgcccatta cgccgacgat cctcacgcga
     7201 agccgatcga gcgggctccc gtttccgacg aagtggatgt caccatcatc ggcgcgggaa
     7261 tcggcggact gcttctggga gcccggctgc gcgaggcgtg cgcattcgac accatccgac
     7321 tcgtcgacaa ggccggggac gtcggcggga cctggtactg gaaccgtttt cccgggctgc
     7381 gctgcgatgt cgagagctat gtctacatgc cgcttctcga agagctggga cgcctcccct
     7441 cggagaagta cgcgaccggc gccgagatat tcgagcactg ccaggccatc gcgcggacat
     7501 acgatctcta tgacgaggcg ttgcttcaga cctccgtcac cgagctgagc tgggacgagg
     7561 attcctcgcg atggctggtg cgcacggacc gcggggacct cgtccgatca cgcttcgtgg
     7621 ccatggcgat cgggtccctg cacaggccca agcttccctc gatacccgga acagaggcct
     7681 tccaaggaca ctcgttccac accagccgct gggatttcgc atacaccggc ggtgacatct
     7741 cgggcgggct ggagaaactc ggggacaagc gggtcggaat cgtcggaacc ggtgcgacgg
     7801 cagtccagtg catcccgcat ctggccgagt cggcagcgca tctctacgtc ttccagcgga
     7861 cgccgtcgac cgtcagcgta cgaaacaaca ggccgaccga cccgggctgg gcggcggggc
     7921 tcgaacccgg ctggcagcaa cggcggatgg acaacttcca tgcgctgacc tcgggcgtcg
     7981 accaggacgt ggacctcgtc caggacggct ggacggagat cacctccaag ctcgccgcga
     8041 tcctcccgaa gtcggcggcc gacgcggacc cgaaggacat cggcaccgcc gtcgaactcg
     8101 cggacttcca caagatggag gagctgagga aacgggtcga cgcgatcgtc cacgacaagg
     8161 acaccgccga cgccctgaag ccgtactacc ggctcttctg caaacgaccg tgcttccacg
     8221 acggatatct ggacacttac aaccggccca acgtcaccct ggtggacacc cagggacgcg
     8281 gagtggagcg cctcaccccg acctccgtgg tggccggcgg ccgggaatac ccggtcgact
     8341 gcctcatctt cgcctcgggc tacgaatccg aattcggcgt cccctacacg aaccgcaccg
     8401 gattcagcat agtcggccgg gacggaattc gactgtccga gaagtgggcc gagggcgccc
     8461 gcaccttcca cggtctccag gtgaacggct tccccaactg cttcatcctg tccaaggcgc
     8521 agtcgggtct ccacgtcaat gtgccgtaca tgctcaatga gcagagcaaa cacgtcgcct
     8581 acatcctcaa ggccgtgcag cagcgcggtc ggcaggtggt ggaagcatcc gccaccggcg
     8641 agaaggaatg ggtggagacg atcctcaggc tggcgaaccg gaacctcgac ttcaccgagt
     8701 cctgcacccc gggccttttc aacaacgagg gaaaccctcg aaatgtggcc atcctcaact
     8761 ccagctacgg aggcggatcg gtcggattcg tcaatatttt gaaacggtgg cgagaggcgg
     8821 acgacctcgc cgacctcgaa ttacgtgaag ggtaggtgtc aagagcaatg gacattacgc
     8881 ggatacctgg ttcggcgatc ggcgcggtcg tggccggcgc cgacttttca ggcaccatcg
     8941 acgacacgca ggtcgaagag atctggcagg ccctcgacca gcacctcgtg ctggttttcc
     9001 gcgggcacaa ggatccctcg aacgacgacc tcctcatgtt cgcccggcgc ttcgggcacg
     9061 taccgaagac cggcctgacg accggtgcca gcccggatca caacgagatc ctcctcatct
     9121 ccaacatcct cgacgagaac gggcagaaga taggcgtcgg caacgcggag tggatggact
     9181 ggcacacgga ctactccttc cgcccgaggg tgtcccgcat cggcttcctg gcggcggtcg
     9241 agctaccgcc gtcgggcggc ggccagacgc tgttcaccga catgtacacg gcctacgaat
     9301 ccctcccgga cgacctccgg cagcgcctgc actcctaccg ggccaggcat tcgctccggt
     9361 ccggctacga ggacgtcatc gaggaggagt accagggcga ggtctccatc gaagggccga
     9421 ccgcgaaacc gttcgtggcc cccgaggacg gtacggcgac ggtccatcag ctgatcgcca
     9481 ggaacccgcg gaccggccgc cgcgcggtgt acgccaaccc gctcaacacc aaacgcatcc
     9541 tcgaactgga cgtcacctcc agcaaggagg tgctccagca gctgttcgcc aagcccggtg
     9601 agccggaact gacctacgcc cacgagtggc tccccggtga catcgtcatg tgggaccagt
     9661 tggggaccgt ccacgccaaa cgggctttcg atccgaccga gcgccggctc ctgcgcaagg
     9721 tcgtcacgat cttcgacgac ccggcggagc cgtggcaccc ggaggacgcg gcgtgatgcc
     9781 gcgcgggccg aggcggtgtc actcgcgcgt cagccaggtc ggcaagcatg gaacagaccg
     9841 tccgcagcgg caacggggcc gcaggcggca tcctcggcca ctcctcggcc ggactccgga
     9901 atgacaggca cgacggcgcc ctcacaccag gagcggcgcc gcagcgttcg tccaccgtgg
     9961 accccgtgca cctggtggac cccgtgaagg gtgtggcgtc atgaccgtga ccccggaaag
    10021 tctgcaccgc agccgcgacg cgatcacacc ggcgttgcgc accgcgctcc acctgctcga
    10081 cgaggagacc cgccatcagg cggcgtacca cctcggctgg atcgaggccg acggcacccc
    10141 ggcggacggc ggcggaggca aggccgtacg gcccgcgctc gcgctgctgt cggcgcaggc
    10201 ggccggcgca ccggcggaaa ccggcctgcc cggtgcggtg gccgtcgaac tggtgcacaa
    10261 cttctcgttg ctgcacgacg acctgatgga cggcgacgag gagcgtcggc atcgacgtac
    10321 ggtctggacg ctgtggggcg cctcgggcgc gatcctcacc ggtgacgcgc tgctggcgct
    10381 cgcgcaggag gtgctgctcg actgcgggct gcccacgggg gcggccgcgg cgcggctgct
    10441 cgcccgcacc acccgcgacc tcatccgcgg gcaggtgcag gacgtggcgt tcgagcggcg
    10501 ggcccatgtg ccgatcgagg agtgcgtcga catggcggcc ggcaagaccg gcgcgctgct
    10561 gtcggccagc gccgcgatcg gtgccgtact ggccggcgcg ccggtgacca ccgtcgacgc
    10621 cctggcgctc tacgggcagc aggtgggcct cgccttccag ctgaccgacg acgtcctcgg
    10681 catctggggc gacccggctg tcaccggcaa gtcggtccac tccgacctgc gggcccgcaa
    10741 gaagtcgctg ccggtcacgt acgcgctcaa ccagggcggg accgtgagtg tcgagctggc
    10801 cacctggctc tccgcaccag gcgagcccga cgaggcagag ctgcgccggg cggccgacct
    10861 ggtggcggcg gccggcggcc gcgactgggc caccgccgag gcggcccggc gcatggcgct
    10921 cggggaggcc gcgctgcgcg gcgtcgacct ggacgccgcg gcgcgcgacg agctcatcgc
    10981 cctcggacac ttcgtcgtcg accgggaggt gtgaggtggc gagcgccgcc ggccggacac
    11041 ccgcccggcc cgcggccgac gctccgcggg ccaggccggc cgacgctccg cggcccgagt
    11101 cggccggcgc tgcgcggccc gagtcgggcc acggccccga accctgccga gccgtcgccg
    11161 aagccctgcc cgcagcgtcc ggaaccgccc cacgcacacg cacacgcaca cgcacggggg
    11221 caggcaacgc cgcccgccct cgtacgacca cccccaccgc aggcagcgcc gcccgcaccc
    11281 gtacgacagc caccaccgcc ctccccaccg caggcagcgc cgcctgctcc cggcggatgt
    11341 ccgcgaccgg caggccgtga ccagccggct cggcgcccgc gggtgtcccc gctggtgccc
    11401 cggaaggccc gcccggtcgt gaccgtcgtt cagccctcca ccgctcaggc cgccttgcgc
    11461 cgatcccacc cccggaggcg cccgctccct cctcacgggt tcccgccgcg cccggcccgg
    11521 ccggcccgtc gaaccccccg tgccgaaacg cttcctcacc cgtcgcggac cggcatggca
    11581 cgcctgtgac ccacaacagc ccccccagga gacccgcaat gccccaggac gtcgacttcc
    11641 acataccgtt ccccagccgt cgcagccccg acttcgagcg ggccagggcc gaccacctca
    11701 gctggccccg cgcgctcggc ctcatcggca ccgacgccgc cgccgagcgc cacagccggg
    11761 gcggctacgc cgatctggcc gcccgcttct acccctcggc caccggagcc gacctcgacc
    11821 tgggcgtcga cctgatgtcg tggttcttcc tcttcgacga cctcttcgac gggccgcgcg
    11881 gcgaggaccc ccaggagacc aggaagctca ccgacgccgt cgccgccgcg ctcgacggcc
    11941 ccctgcccac gtcggcgccg cccatcgccc atggtttcgc cgacgtgtgg cggcgcacct
    12001 gccagggcat gtcccccgcc tggcgcgcgc gctccgcccg gcactggcgc aactacttct
    12061 ccggatacgt cgacgaggcg gtgagccgcc acctcaacac cccctacgac tcggccggtc
    12121 actacctcgc catgcgcagg cagaccatcg gcgtgcagcc caccgtggac ctggccgagc
    12181 gcagctgcca ctgcgaggtg ccccagcggg tgttcgacag cgccgtgctg ttcgcgatgc
    12241 tccagatcgc caccgacacc aatctgatcc tcaacgacat cgcctccctg gagaaggaag
    12301 aggcccgcgg cgagctgaac aacatggtct tcatcctgat gcgcgagcac ggctggacgc
    12361 gcggccgcag catcgcgcac atgcaggacg gagtccgcac ccgcctcgaa cagttcctgc
    12421 tcctcgaggc ctgcctgccg aaggtctacg acaccttcga gctcactgcg caggagcgcg
    12481 agagcgcgga gaagtaccgg atggacgggg tgcgttcggt gatccggggg tcgtacgact
    12541 ggcaccgcag ctcgggccgg tacgccgccg actacgcgat cgccgccagc taccagggct
    12601 acctcgagga gctgggcagc acgctgtagc cgcccaggag ttgaccagcg cacggagcca
    12661 gcaatcgagg aagtcgagga ttccgatgtc ccagcacacc ttcgtcgccg gaacggcccc
    12721 cggggccgtg cccgtagtgg ggcacgcctg gcagatgatg cgccgccccc tgcacttcat
    12781 gtcctcgctg tccgcgcacg gcgacctggt gaagatacgc attggcccga cgtccgccta
    12841 tgtgccctgc caccccgagc tgctgcggca ggtactgacc aacgaccgcg tcttcgacaa
    12901 gggaggagtg ttctacgacc gcgcccggga catcgccggc aacggtcttg tcacctgccc
    12961 ctaccgcgac caccgcaggc agcggcgcct gatgcagtcg gccttccagc gcacgcagct
    13021 ggagcggtac tccacggcga tgcgcgcgga gatcgacgcc acggcggcgc ggtggcacga
    13081 cggcacggtc atcgacgcct tccccgagct gtacgggatg gcgctgcgca ccgtggcccg
    13141 cacgctgtac tccaccccgg tcaccgagga actggcacag cgcgtcgaac aggcctttga
    13201 caccgtactc aacgggctct tccgccagat gttcctgccc cactccctgc ggcggctgcc
    13261 gaccccggcc aacctccgct accgcaacaa cctgcgcttc ctgcacgaca ccgtgcagga
    13321 cctgatcacc gagtaccggc gggacgacac ccagcgcgac gacctgctgt ccgcgctgct
    13381 ggcgtcccgt gacgaggacg gcggacggct gggcgacacg gagatccacg accaggtcat
    13441 caccgtgatg gcggccggaa ccgagacggt cgccggcacc ctcacctgga tcttccatct
    13501 gctctcccgg catcccgaga tcgaggcgag gctgtacgag gagatcgaca ccgtcctaga
    13561 cggaaagccc ccgcactggg acgacctgcc gagcctgtcc ctgacggacc ggatcatcac
    13621 cgaagcgctc cggatgtatc cgccggcctg gatcttcacc cggctcaccg cgtcggacgt
    13681 cgacctcgcg ggggtgcgcc tgcccgaggg caccaccatc gtcttcagcc cctcctccgt
    13741 gcagcgtcac tcggaggcct acgacgacgc gtcccggttc gaccccgacc gctggctgcc
    13801 cgaccgcacc tcggccgtcg cccggcaggc gttcacggcg ttcggcaccg gcgcgcgcaa
    13861 gtgcatcggc gacctgttcg cgcggaccga ggccaccctc gcgctcgcca cgatgctgag
    13921 ccagtggcgg gtcaccgtgg agcccgacgc ggacgtccgg cccgtcgccc tggccaccgt
    13981 gtaccacccg cgccgcctgc gcctgcggct gacggcccgt acgccgggtc agtagccggg
    14041 agacgacgcg gctcgtgccg gggcgttgtc ggtgccccgt gccatcctga tggcatggcg
    14101 aatctggagg acctggtcag gttgcggaag gcgcgcgacc ggatggaccg cgagtacgcc
    14161 gagcagctgg acatagcggc gctcgcgcgg acggcgctga tgtcgccggg ccacttccag
    14221 cgcagcttcc gggcggcctt cggcgagacg ccgtacagct atctgatgac gcggcggatc
    14281 gagcgggcga aggcgctgct gcggcggggc gacctgacgg tgacggaggt ctgtctggcc
    14341 gtggggtgca cctcgctggg ctcgttcagt tcgcgcttca cggagctggt gggcgagacg
    14401 ccgagcgcgt accgggcgcg gtcgcacgaa cacggggcac ccatcccgcc gtgcgtggcg
    14461 aagggcctca cccgcccgag acggggccgc cccgtgtacg ggcgggcaga tacggcaggc
    14521 gggacatgga cgacagggcc tagcgtgacc tcatgaacat ggacaccgat ccgggcgtga
    14581 tgctctcgca gtgcttcatc gccgtcgacg accacgacaa ggcactcgcg ttctaccgtg
    14641 acgtcctcgg cctggaggtc cgcaacgacg tgggcttcga gggcatgcgc tgggtgacgg
    14701 tcggctcgcc gctccagccg gacgtggaga tcgtcctgga gccgccgggg gcgaacccgg
    14761 acgcgtccga agcggaccgg caggcgatgg ccgagctgct ggccaagggc atgctgcggg
    14821 gggtcatctt ctcgacgccg gactgcgacg ccctgttcgc ccgcgtcgag gcgtccggcg
    14881 ccgaggtcct gcaagagccc atggaccagc cgtacggcgt gcgcgactgc gccttccgcg
    14941 atccggcggg caacctcctg cgcttcaagc agcgctccgc cgcctgacgc ggaaacctcg
    15001 ttgcgcgggc gggccgggcg ggagacggta cgaggccatg tacacggtgg ggggccatgg
    15061 cccccgtccg gcccggcagg gagcgatcca tgagtgaacc gatccgttgg gcgtacgcct
    15121 tcgtcgaccg gcccgcggcg gagttcgtcc gggccgttga cttctggacc gccgtcacgg
    15181 cgaccgagcg gtccgaatcc cgcggcgacc agggcgagtt cgtgtcgctg ctgccggggg
    15241 cgggcgacgc gtgcgtgaag gcgcaggggg tgcgggacgg taccgggggc gcccacctcg
    15301 acctcgccgt cgcaaacgtg ccggcgctcg tcggggcggc gcggcggctc ggcgccgagg
    15361 tcgtcgccga gcatccgggg tgggccgtac tgcgctcccc cggcggccag ttgttctgcg
    15421 cggtcccctg gcacggcgag tcggcgcggc cgcccgtcgt cgagggcagc cgcctcgacc
    15481 agctgtgcat cgacctcgcc ccggcggtgt acgacctcga cgtcgcgttc tggagcgacc
    15541 tcaccggctg gacctcccac cccggcgccc tcccggagtt ccacctggtc aggccgcccg
    15601 aggggctgcc gatccgtatt ctcctccagc gcctgggcac cgatcgcccc acctccgccc
    15661 acctcgacct cgcctgcgcg gacatcgagg cgacacgggt ccggcacgag gagctgggcg
    15721 ccacgctcgt cgcccgcggc gcccggtgga cggtgctgcg cgaccccgcg ggcggaacgt
    15781 actgcctgac ggcccgcgac ccggaaacgg gcagcctgcc ggcctagtcc ctaccggtcc
    15841 gggtcagccg tcgcgtacac acacagcacc gcctgcccgt cggacgcacc cgggcacggc
    15901 gggtggtcgc ggacgtccgc ggacagcagc ggtgccgggg cgggctccca gcctgtcgga
    15961 ggcggcggct ccgtcgagtc ctggagccag agcgtgagcc cgccgcccac gagcacggcc
    16021 gccgcccaca cgccgatggc ccagcgccag acgcgtcgcc gtccccgctg cggggccgcg
    16081 cgcccgtcgt cctcccccgg tcctccctcc accccgctca cgccgaagcc gcttcgccgc
    16141 ccgtccagac ctccacgtcc acgacggccg acaccggaat cggcccgtag acgtgcggga
    16201 actcctcgcc gccgggcccc acggcctcgt accgcacggg cgccgcgagc cgctccgcgt
    16261 ccacgaccag caccaccagc tcgtcggacc cggcgcggga tccgtacagg agcgctgcca
    16321 cgccggggag ctgatgccgc agcgagcagt gaatgaagcc ctcctcctgg agggtgcggc
    16381 cgcgcgtcgc catctcgtac gtgccacggt cgcgggcggc gtcccacagg gagcgctcgg
    16441 taaggtgcag aaggggttcg gacatggcgt aacgctaagg cctgcgccgg gccgcccgcg
    16501 cctgcgtcaa ccgccccgca ccgtgaccag gtacctcatg atgaccaggt acctcatgcg
    16561 tcatggcgcc ttcgcggccg gcgcttctgg tggcgcttcg ggcggcccag ggcgttccgc
    16621 cgccgccccg cctccgggta cgtacgccgt gcaccgggga ttccggcacg gggcgggtcc
    16681 ccacacgggg acgaaggcgc cgagcgtctt gtggcgccgc acgaccgtgc cgacaggctg
    16741 tccgcacgag ggacacgcat actcatcgct gcccatgtcc tcagggtatt gcggtacggg
    16801 gtccggcgcc ttcccgccgc ggactagctc cggggctccc gccacatcgg ccacatccgc
    16861 gggccgtccg gcaggtcgag cgcgggggtc gtggagacga agccgaggcg ttcgtagagc
    16921 ttgcggctgc gggcgctgct ggcctccaga taggcgggca ggcccgcgcg gtcgcagcgg
    16981 tcgaggacgg gctgcatgag cgccgtgccg aggccctcgc cctggcggcc gggggccacg
    17041 gcgatcatcc acaggtacgc gtgggcccgg cccgacggat ggatcccgct cgtcagccgg
    17101 ccgatcagct cgacacggtc gttgtccggg tcgacggcct cccgcagccg ggccgggccg
    17161 tcctcctcgt cgtgcgcgtc ggcgggcagg gacagccaca gcgcgcacgc ggtgccgtcc
    17221 tcggtgaggt cgacgcgccc ctcgccgagc acgatgtcgg tgaaggccgc catcagccgg
    17281 tggtgcgtgg cccggcggta cgcctcgccg gggaagaccc agctgctcac cgggtcgtgc
    17341 tggaaggcct cgtccagaag ccggacgacc gcctcgcgat cgccctcgcc cgccgtccgg
    17401 atcgccacgc ccatgtcccg ccccttcacc tcaaccagcc ctgtccgtac ggctgttgca
    17461 gccgacacgg ccgttgcagc gtagtcggtg tgcgcgcggg gcggtatgag gggacgggcc
    17521 ccgcgcaccg tggggatgcg cgggacccgc cccggccgga gcctccgggt gccgtgcggg
    17581 gtcaggagcc gcatggcccg aaggctccgg ggtcttgcgg gggccgtcgg ccgcttcagt
    17641 tgctgcgccg ggtcacgaac tcggcgaggg cgagcaggcc gcccgccgcc tccgggtccg
    17701 gaatcgcccg ggacagctcg tgcatcgccc gggccatccg gtcggcggcc tgctgctggg
    17761 cccagtcgcg gccgccggcc cgctcgacgg ccaggaccgt gcgctccagc tccccttcct
    17821 ggtgcggaac cgcgtacagc tcggcgagtt ccgccgccgc cggagtgccc gcggcgagcg
    17881 cggccaccac gggcagggac ttcttgcggg ccatcaggtc cgccccggcc ggcttgccgg
    17941 ttcggctcgg gtccccccag atcccgatca cgtcgtcgat gagctggaag gcgagcccgg
    18001 cctcccggcc gaacgcgtcc agcgcctcga cgtcctcctc ctccgccccc gcgtacaacg
    18061 cccccagcgc acaggcgcag ccgagcagcg cgcccgtctt ggcctcggcc atggcgaggc
    18121 actcgtcgag ggtgacctca cccgggccgc gccgctccat cgccgtgtcc gcgtgctgcc
    18181 ccgcgcacag ttcgatgaca caggccgcga gccgggcggc ggccgccgcg gacgccgggt
    18241 gcgggtcctc ggcgagcagc cggtgggcca gggcctgaag tgcgtccccg gcgaggatcg
    18301 cgtcggcgtc gccgaacacg gtccacgcgg tggggcggtg cctgcgggtg gtgtcccggt
    18361 ccatgacgtc gtcgtgcagc agggtgaagt tgtggatcag ctccaccgcc gcggcggccc
    18421 gaacggcgga ggactgcggt ccgccgagcg cccggaccgc ggccagcacg agcgcggggc
    18481 ggatcgcctt gcccgcgttg cctgccgccg gggtgccgtc cgcgtgctcc cagccgaagt
    18541 ggtggagcgc gatccggcgc atggaccccg gcagcgagtc gacggcccgg cgcagctcgg
    18601 ggtcgaccga ggcccgggca cgctccagga tccccgcggc ttcctgcccg tcgagctggg
    18661 ccgccgggcc ctgcggatcg gtgggcggac tcgcggccgg cgcctgccgc ccggtggacg
    18721 gagccgggag cgggcctcgc cggccggcgg ggcccgcggg gctccgcctt tcgagcacct
    18781 cggccgggct ctgcttcgcc tccgtcagga actcacccat gcgaccacct caactcaccc
    18841 atgtgaccac ctcggagagt ccccggacga tgacgcttcc gctgccgccg cgcgcatacc
    18901 cctggggtgt acccgccctg ccgggcgggt acacgacacg ccgctcgtgc ggaaggtcac
    18961 cgccagcggc cgatctcgac gttctccagg atgccgaggg cgtcgggcac gagcaccgcg
    19021 gccgagtagt aggccgtgac caggtaggag atgatcgcct gctcgttgat gcccatgaag
    19081 cgcaccgaca ggctcggctc gatctcgtcc gggatgcccg cctgctggag tccgacgacg
    19141 ccctgctcgt cctcgcccgt acgcatgcag atgatcgagg tggtacgggt gtcgctgacc
    19201 gggatcttgt tgcacgggaa gatcggcacc ccgcgccagg tggggatgcg gttgcccgcg
    19261 atctcgacgc tctcggggac gagcccgcgc cggttgcact cgcggccgaa cgcggagatc
    19321 gcgcgcgggt gggcgaggaa cagcttggat ccgcgcctgc ggctgaggag ttcgtccagg
    19381 tcgtcggggc ctggcacacc gtcgtgcggc tggagccgct ggtcgtactc gcagttgttg
    19441 agcagcccga actccctgtt gttgatgagt tcgtgctcct ggcgctcctt caacgcctcg
    19501 acggtgagcc tgagttgctg ctcggtctgg ttcatgggct ggttgtagag gtcggccacg
    19561 cgcgtgtgca ggcgcagcac ggtctgggcg atgctcagtt cgtactcgcg cggcgtggcc
    19621 tcgtagtcca cgaaggttcc ggggatgtcc ggctctccgg tgtggcctgc cgcaaggtcg
    19681 atctccttct cgccgtactt gttggtgcgc tgctcgggga tcgcgcgggc ctgctggagg
    19741 tggtcgcgca gggactcggc gcgctcggcg acctggtcga cgtcccggcg gggcagggtg
    19801 agcacggtgc aggcggtgac cgcgcgtgcc gtgtactccc agatggcctc cgggtcgatc
    19861 agcgcctgct cgccgaagta cgcgccgtcg gcgaggactc cgagtaccgc gtcgtcgccg
    19921 tacgggcccg tgcccacctt ctcgaccttg ccgtgcgcga gcaaaaagac ctcgtcggcc
    19981 cggctgccga acgaggcgag cacctccccc ggtgcgaact cccgctgctc gcagcgctgg
    20041 gcgagctcgc cgagcacctc ctggtcctcg tacgtccgca gcagcgtcag ttcgccgagc
    20101 tccgcgggaa tgacctgcac acggtcaccg gtcttcacga aggtgacacg gccgtcgccc
    20161 acggagtaac tgagccggcg gtttactcgg tacgtgccac cctgcacgtt cacccacggc
    20221 agcatgcgca gcagccaacg tgagctgatc tcctgcatct ggggtgcgga cttggtggtc
    20281 gtggccaggt tccgcgcggc cgatgtgccg agactctgct ggggcctgcc ctgctccgcg
    20341 cggacctctt cgcctaccga catgaaaatt gccctcccga tcatgcgctg atgcacggac
    20401 aagcctccag cacggagcgt gtcggtgcta ttacacgaat gagcgggaat ggatcactgg
    20461 cgcactgggc acactggtgg acccggtcgg gccgtcgggc cgtcgggccg tcgagccgtc
    20521 gagccgtcga gccgtcgagc cgtcgagccg tcgaactggt gcgctgggga acttcaagat
    20581 ccggccgtcc gtttcatccc tcgacgacac aagtgcgcgt acgaggacag gtacaaggac
    20641 gaggacggga gacagcgatg gcaggcttcc tggaccgcgc gaaggaacag gcgcaacggg
    20701 gcctcaccca gggccggcag aagctggacg aggtgcaggc acagcgcgcc ggcggtgatt
    20761 tgctcaagaa actgggcgcc gcgtattacg cggagcgacg cggcagcggc tcccccgggg
    20821 cgacccagca ggctctccag gccctggaga gccacatcgc ggtgaacgga gacgctttcc
    20881 tccactcctg acggcacgac agaacctgcc cgtcccgccc ggaccgccga gtcggcaggg
    20941 tcggccgaat cggctcgcac gctgtgcgaa cgagtgggcc gcccagtcgc gttccgggta
    21001 caagcctcgg tacgaggcgg tcgcgacggg cggccgtcgc gcagcgctaa ggaggcggtc
    21061 atggccccac ccatgtccgc gggcagtttc ctggaccggc tcagagagga aggcgtcacc
    21121 gtcgtcgagg tcggcgactg ggagcatcac aaccgcaatc acaagggccc ctgggggccg
    21181 gtccacggtg tgatgatcca tcacaccgtc acctcgggca gcgaacacac cgtcgagctc
    21241 tgccgcgacg gctacgaggg gctgccgggg ccgctgtgcc acggggtcat caccaaggac
    21301 ggcgtcgtcc acctggtcgg ctacggccgc gccaaccacg cgggtctggg cgacgacgac
    21361 gtgctgcgcg ccgtgatcgc cgagaaggcc ctcccgccgg acaacgaggc gaacaccgac
    21421 ggcaaccgcc acttctacgg cttcgagtgc gagaacctgg gcgacggcac ggacccctgg
    21481 ccggacgccc agctggaggc gatcgagaag gtctcggccg ccatctgccg ccatcacggc
    21541 tggtcggagc gctcggtcat cggccatctg gagtggcagc cgggcaaggt ggacccgaga
    21601 ggcttcacga tgacctggct gcgggagcgg atccgcgacc gtctgaagtg acggcggccg
    21661 ggcggccccc tccgcacagg tgtccgacaa tggtggggtg accggccccg acgtccccga
    21721 agcgctcgac ctcgccgccc tgcgaccgcg cctgccgtcg ccggtgcagg cggtcgacga
    21781 cgagcgcttc gcacggcacg gggtccggct cctgctcaag cgggacgacc tgatccaccc
    21841 ggacctcatc ggcaacaagt ggcgcaagct cgcgccgaac ctccgggccg cggcgggccg
    21901 cccgctcgtc accttcggcg gtgcgtactc gaaccacctg cgagcgacgg ccgccgcggg
    21961 ccgcctcctg gggctggcca cgatcggcgt ggtccgcggc caggagctgg ccgaccgtcc
    22021 gctgaacccc tccctcaccc ggtgcgcggc cgacggcatg cggctgcact tcgtggaccg
    22081 gtcgacgtac cgccgcaaga ccgaaccggg gacgctggcc gcgatcctgc gcgcggtggc
    22141 cgccgaggac gcgtacgtcg tgcccgaagg cggcagcaac tcccctgccg tacgcggctg
    22201 ccgcgccctc ggcgaggagc tgcgcgggca cgccgacgtc gtcgccctcg cctgcggcac
    22261 cggcggcacg ctcgcgggcc tggccgccgg cctcggcccc ggccagcggg cgctgggcgt
    22321 cccggtcctc aagggcgact tcctgaccgc cgaggtcacc gcgctccagg agcgggcgtt
    22381 cggcggccgc cagggcgcct ggtccctgga cgaccgcttc cacttcggcg gctacgcccg
    22441 tacctctccc ggcctccacg cgttcgcggc ggacttcgag cggcgacacg gactgccggt
    22501 ggaacgtctc tatgtcgcca agatgctgta cggacttgtc gccctggccg aagagggcgg
    22561 gttcgcccgc ggcacgaccg tcgcggccgt catcaccgga cggccgctcg gctgaggcgg
    22621 ctcaggtcgc ctcccgaaag gccgccgcct cctccaggtc caggcgtctg agcagcgtgc
    22681 gcagcatctc gtcgtcgatg taacggccgt tgcgcagcct cacgaagacc gagcgttcgg
    22741 cggcgatcat ctcgcgcgac aggcgccggt aggtgtcgtc gacggactcc ccggtcaccg
    22801 ggttcaccgc gccgagccgc tcccagaccg cgttgcgccg ccgttccagg acgtcacgga
    22861 gccggtcggc caggggcggc ggcagagcgt tgcgctcgtc gtcgaggagg tcgttcagcc
    22921 gcagctcggc gacccgggag gcctgggcct gggcattggc ctccgcgagc gtctcggcct
    22981 gcgcgtcgcg ccccgggagt ctcagcagac ggatcagcgg gggcagggtc aggccctgca
    23041 cgaccagcgt gccgatcacg gtcgtgaagg tcaggaagag gatgaggttg cggccgggaa
    23101 agggaccttt cccttgcccg tggacggtca gcgggatcga gaaggcgatg gcgagcgaga
    23161 ccacgccccg catgcccgcc cagccgatga tgaacggcgc cttccaggtg gggttctcct
    23221 cgcgttcccg gatgcgcgcg gagagcaggc gtggcaggaa ggtcgccgga tacacccaca
    23281 cgaaccgcgc gaggaccacc accaggaaga cggccaccgc gtaccaggcg gcgtcgacgc
    23341 cccggtactc cccgagcccc ttcagcacga cctgcagttg caggccgatc agcgcgaaca
    23401 ccgccgactc caggacgaac gcgaccatct tccacaccgc ctcctcctgg agccgggtgg
    23461 cgaagtcgac ctcgtagttg cgatgcccga ggtagagggc gacgacgaca acggcgagca
    23521 ctccggaggc gtgcgcccac tcggcgagcc cgtacgcgac gaacgggatc agcagggaga
    23581 gcgtgttctg cagcagcgcc tccttcaggt gcgtgcgcag ccagtgcagc ggcaccatca
    23641 gcagcagccc gaccgccacg ccgccgaccg ccgccagcag gaactcgccc accccgtgcg
    23701 cccaggtcgc accctcgccg accgcggcgg cgagggccac cttgtaggcg gtgatcgcgg
    23761 tcgcgtcgtt caccagggac tcgccctgga ggatcgtggt gatccgcgag ggcagcccca
    23821 cccgccgcgc caccgccgtc gccgcgaccg cgtccggcgg cgcgaccacc gcgccgagca
    23881 ccagcgccgc gggcagcggc aggcccggca cgagcagata cgcggcccag cccacgacca
    23941 gggtcgcgaa gaggacgtag ccgatggaca gcagcgccac cggtcgcagt tgcgcgcgca
    24001 gatcgaggta cgagctgtcg ctggcggccg tgtacagcag cggaggcagc accagcggaa
    24061 gcaccacctc cgggtcgagg gtgtactcgg gcaccccggg gatgtacgag gcgatcaggc
    24121 ccgcagcgac gagcagcagc ggtgcgggta cgggcgtacg gcgtgcggct ccggcgaccg
    24181 cggcgctgcc cgcgaccagc aacagcagtg gcaatacgtc catcgtcttc cgcccgccct
    24241 ctttttcgcg cggcttcccg cacacccgtc gtaacctggc aatcatgaaa cagtgcacgc
    24301 acgccgacgc gctgccgcac ccggagcccg aacctctgag cgaaacctgc ccggagtgcc
    24361 tggccaccgg cacgcacccg gtgcaactac ggctgtgtct ggtgtgcgga cacgtgggct
    24421 gctgcgattc gtcgccgcgg cgccacgcga cggagcacca caaggaaacc gggcaccccg
    24481 tgatgcgaac cttcgagccc ggcgaaagct ggcgctggtg cttcgtcgat catgtcctcg
    24541 tgtgactacg ggccgtactc gtgtgaccct gggtccggac ggttcgaccg tctgacgcct
    24601 gggtacgtca acccggcgcg cgctcttccc aattgggccc gcagacccct agccactgtg
    24661 cgtatacata ggtttactat gagtgacagc aaggggttgg ggtcccgggg acagaaaacc
    24721 tgagagcgcg gtagcgtcac cgctgaacca cctagcgcgt taccccgggg ggcgaccctc
    24781 ggcccccgaa aaagcttgta ccaccttgga ggtgagggtg tcccagatcg acggcgagcc
    24841 cgcgacccag gacttcgtgg aagtccggct gccggccgcg ggtgcctacc tgtcggtgct
    24901 gcgtacggcc acagccggtc tcgcggcccg tttggacttc accctcgacg agatcgagga
    24961 cctgcgcatc gcggtcgacg aggcctgcgc gatcctgctc cagcaggccg tgccgggctc
    25021 ggtgctcagc tgcgtcttcc ggcttgtcga cgactcgctc gaggtcacgg tctccgctcc
    25081 gaccacggac ggtcacgccc cgtcgcgcga caccttcgcc tggaccgttc tgtcggccct
    25141 cgcgggcaag gtctcctccg cggtcgccga cgacaagact gtgtccatca gcctctacaa
    25201 acagcgcggc gcgggacccg ggccggcgtg aggaacgggg acgggccggt gcaggacgaa
    25261 gagcgcggca cacgggaact tcccaccgag gacgggggtg ccccctgctc gatcggagcc
    25321 gacagcctgg ggggcggcgg ccccagcggg ccgcggcgca cggcggacgg catcgacggc
    25381 atccccgagc aggcccggcc gcaccccgag gaccactcct cggcggcggc cgagggttct
    25441 cagcagcaag agccgttcgg cgagggcggg cgcgcggcgc gctccgtccc ggtcgacggg
    25501 cgacgggatc cagcgggtgc ccgcggggag gctctgcgga cggagtccgg tggagcgtcc
    25561 tcgaaagggc ggcgcgtgac gggcgggacg atgagcgagc acgagcgaaa cgctgagccg
    25621 agtgtgccga gcggcacaca gcacgacccc caggaccgca gcggggcgcg cgccctgttc
    25681 atcgagctgc gcatgctgcc cgacggcagc ccggagtacg cggagctgcg caaccggctg
    25741 gtccgtatgc atctgccgct cgtggagcac ctcgcgcgcc gcttccgcaa ccgcggcgag
    25801 ccgctggacg acctcaccca ggtcgccacc atcggtctca tcaagtcggt cgaccgcttc
    25861 gacccggagc gcggcgtcga gttctcgacg tacgcgaccc cgaccgtagt cggcgagatc
    25921 aagcggcact tccgcgacaa gggctgggcg gtccgtgtgc cgcgccgact ccaggagctg
    25981 cgcctcgccc tgacgacggc cacggcggag ctgtcccagc agcacggccg ctcgccgacg
    26041 gtgcacgagc tggccgagaa gctggccatc tcggaggagg aggtcctgga gggcctggag
    26101 tccgcgaacg cgtactccac gctgtccctg gacgtccccg acacggacga cgagtccccg
    26161 gcggtcgcgg acacgctggg cgcggaggac gaggcgctgg agggcgtcga gtaccgggag
    26221 tcgctcaagc cgctgctcga ggacctcccg ccgcgggaga agcggatcct gctgctgcgt
    26281 ttcttcggca acatgacgca gtcgcagatc gcgcaggagg tcggcatctc acagatgcac
    26341 gtctcgcgtc tgctggcccg caccctggcc cagctgcggg agaagctgct cgtcgaggag
    26401 tgagccggga agcgcccagc gtctccgccc gctccggccc caccccgcac gcgtcgctac
    26461 ttctcgtcct gcacgttccc gggcctccgg ataccgagcg cccgggtcgt ggccgggttc
    26521 acgagcagca ccagagccgt gaccgcgacg gccgcgagcg cgattcccgc ggggatggcg
    26581 atgctgtcgg cctggagcag gctgtaggcc acgggcagcg ccatgatctg ggtgatgatc
    26641 gccgggcccc ggctccagcc gcgccgcagc agcagcccgc gcgccgccag caggggcagc
    26701 agcgcgagca cgagcagcgt gatgccgccg gtgacggcct gctgccggtc gtccgggtca
    26761 cccgtgacgc ctcgtacgag catccagaca ccgcccgcgg ccagcgcgag cccctccagc
    26821 gcggccagcg ccgccgcggc ggtcagccgc ccgggacggg gctcggcgtc ggaggtgtcc
    26881 gggacgcggt tctgctcagc actcacccct gcagggtagc cgtcggccac tggcctccct
    26941 ccctcccggg cacctccact gtgcccaagg ccacgcctcg aactcttacc cgatctctac
    27001 ctcggcctgg gccgagtacc gcccagtagg taccctgcat cgcatgcgtg cacttctcgt
    27061 ggtcaatccg gcggcaacca ccacaagcgc acgtacccgt gacgtcttga tccacgctct
    27121 ggcgagcgag atgaaactcg aggcggtcac caccgagtac cgcggacacg cccgggacct
    27181 cggccggcag gcggcggaca gcgaggacat cgagctggtc gtggcgctcg gcggcgacgg
    27241 cacggtcaac gaggtcgtga acggcctgct gcaccgcggc cccgatccgg agcacctccc
    27301 ccgcctcgcc gtggtccccg gcggctccac caacgtcttc gcacgcgccc tcggcctgcc
    27361 caacgacgcc gtggaggcca ccggcgccct gctcgacgcg ctgcgcgaga agcgtgagcg
    27421 caccgtcggc ctcggcctgg ccgccggcac cccgggcacg gaggacgagg cggtcccgtc
    27481 ccgctggttc accttcaacg cgggtctcgg cttcgacgcg ggtgtggtcg gccgggtcga
    27541 acaacaccgc gagcgcggca ggcgctccac gcacagcctg tatttgcgcc aggccatacg
    27601 ccagtttttg gacgaacctc accgcaggca cggaacgatc acgctggagc gacccggcgc
    27661 ggccccggtc acggatctgg tcctgtccct catctgcaac acctcaccct ggacgtttct
    27721 cggcaatcgt ccggtgtacg cgtcacctaa ggcctcgttc gataccgggc tcgacatact
    27781 cggcctcagc cgcatgtcga cggcctcggt tgcccggtat gcgacccagt tgctcacttc
    27841 gtcccccgag cgcggacccc atggcaaaca cgccgtatcg ctgcacgacc tgaccgactt
    27901 caccttgcat tcgaaggcgc ccctacccct ccagatggac ggcgaccacc tcgggctccg
    27961 tacgagcgtg acgttcacag gcgtacgccg tgcactgcgt gtgattgtgt gagcggaacg
    28021 agccaaactc ctttcactcg aacgtttaga ccacggtcca ccccatggaa gtacggctgt
    28081 gacctagtcg acaccgagga atcaaaaaaa actttccgga aggggttgta tccgccgctg
    28141 aggtttgcga gtctctacgt ggcgatcgag acggcccgca acaccggcct ccacagagag
    28201 ccagaacccc tcctcaatcc aaaggaccac gtcagtccgt ctgacgatcg gcccttcact
    28261 tgttgaggga ttcgtgaaag cgttcacatt cacaagcaac ctgaatgtaa taccaaggag
    28321 aggtagcagc catggactgg cgtcacaacg ccgtttgccg cgaggaagac cccgagctct
    28381 tcttccccat cggcaacacc ggtcctgcgc tgctgcagat cgaggaagcc aaggccgtct
    28441 gccgccgctg ccccgtcatg gagcagtgcc tgcagtgggc gctcgagtcc ggccaggact
    28501 cgggtgtctg gggtggcctc agcgaggacg agcgtcgcgc catgaagcgc cgcgccgccc
    28561 gcaaccgggc ccgtcaggcc accgcctgac gccccacccc gcaacgagcc tgagcttggc
    28621 ggcgcgtaca gcgcgtacgc atctcccgcc cccgagccgc agcgcgcagt acccccgatg
    28681 cgcatagcac gagcacggtg aaccccggac catcaactgg tccggggttc attgctgttc
    28741 ttcgccgttc ttcgccgttc tcgccgttct tcgctggtct tccctgttct tcgctggtct
    28801 tcgcgggtgc gatcgatccg
//
