LOCUS       NC_003155              11446 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2692351
            Orig. end                         :: 2703797
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11446
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="16"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11446
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11446
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6446](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6446
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            260..1642
                     /db_xref="GeneID:41539308"
                     /locus_tag="SAVERM_RS11605"
                     /old_locus_tag="SAV_2213"
                     /old_locus_tag="SAVERM_2213"
     CDS             260..1642
                     /codon_start=1
                     /db_xref="GeneID:41539308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385420.1"
                     /locus_tag="SAVERM_RS11605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2213"
                     /old_locus_tag="SAVERM_2213"
                     /product="PhoX family protein"
                     /protein_id="WP_010983653.1"
                     /transl_table=11
                     /translation="MPENGRPASRRQVLARSGALGVSIAFAGNLSELFAGTAAAQDLGH
                     RGYGPLVPDPNGLLDLPKGFRYRVLSREGDPLRSGEGPVPSNHDGMSAFAGRHGRVHLV
                     RNHENRVTAKFPVPTVEGLTYDPTGKGGCTALTLDGQGQVLSERVAIAGTAVNCAGGPT
                     PWGTWLTCEETEDRAGTNGYTKDHGFIFEVDPANPHRTGAVPLTAMGRFQHEAIAVDPR
                     HGIVYETEDAFLKPFGLFYRFLPHRPEGGVGSLRAGGRLQAMRVPGVPDLSSVQETGAA
                     FDGVEWVDVPDPLAAQTPVRLQDFGPKGITHAQKLEGCYWGGSCVYFVSSFARGADGSA
                     ADHYGQIWRYDPSARRLTLVIVFGPDTDVQLPGESPDNICLAPGGGLMVCEDGNGAQHV
                     FGVTRRGEVYALARGAQNIGTPEAPEWGEFAGVTFSPDGRTMYVNCYTPGTTFAVTGPW
                     RR"
     misc_feature    complement(1866..1877)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     gene            1880..2749
                     /db_xref="GeneID:41539309"
                     /locus_tag="SAVERM_RS11610"
                     /old_locus_tag="SAV_2214"
                     /old_locus_tag="SAVERM_2214"
     CDS             1880..2749
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539309"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063345.1"
                     /locus_tag="SAVERM_RS11610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2214"
                     /old_locus_tag="SAVERM_2214"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_010983654.1"
                     /transl_table=11
                     /translation="MIILVRRVAVAGALGALGAALAACGTPGASGTPHAAARPAHSAPT
                     TAASSKPPTLTPGPSGLTPVFKNGPRTQGKTVALTFDADMTADQGARAAAGEHFDNPQL
                     IGALRELKVPATVFMTGRWADEYPQEARAIGRDPLFEVANHSYSHYAFTSDCYGLPTVS
                     EDRMRSDVERAFAAFEKAGVPHVMPYFRFPGGCYDQRALRTLIPVGVTAVQWDVVSGDA
                     FATDADAVAQQVLEGVRPGSVVVMHCTRSAAPTTERAVRTIVPELRKKGFRFVKVSELI
                     QAASGGRR"
     misc_feature    complement(1881..1894)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.81"
                     /tool="antismash"
     misc_feature    1882..1895
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.09"
                     /tool="antismash"
     gene            2803..2982
                     /db_xref="GeneID:41539310"
                     /locus_tag="SAVERM_RS11615"
                     /old_locus_tag="SAV_2215"
                     /old_locus_tag="SAVERM_2215"
     CDS             2803..2982
                     /codon_start=1
                     /db_xref="GeneID:41539310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019981773.1"
                     /locus_tag="SAVERM_RS11615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2215"
                     /old_locus_tag="SAVERM_2215"
                     /product="hypothetical protein"
                     /protein_id="WP_010983655.1"
                     /transl_table=11
                     /translation="MSGDYCGTETAGPAPKAGGPPFAACVLCQEPTEYPESYKGITLCP
                     VCAWQEAQRGACSG"
     gene            3055..3828
                     /db_xref="GeneID:41539311"
                     /locus_tag="SAVERM_RS11620"
                     /old_locus_tag="SAV_2216"
                     /old_locus_tag="SAVERM_2216"
     CDS             3055..3828
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445276.1"
                     /locus_tag="SAVERM_RS11620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2216"
                     /old_locus_tag="SAVERM_2216"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_010983656.1"
                     /transl_table=11
                     /translation="MTSDPTPATPATPATPAAPAVDGSAPQDSPFRSERTSRDEARQFV
                     LPLVVRIEKSAPPARTDALETAARAVLVILSDERSLGDGEWAQAMTDWQDARIRKVVRR
                     ARGAEWRRAEALPGITVTGKSAEVRVFPPVPLDGWPKDLARLQVSGTDLEDFEPPLEAD
                     PSAPVLRLSPDLDMSAGKAMAQAGHGAQLAWWELSDEDRAAWRDAGFPLAVRTADPSHW
                     RELTASGLPLVRDAGFTEIAPGSCTVVADHPALRG"
     misc_feature    4006..4019
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            4006..4794
                     /db_xref="GeneID:41539312"
                     /locus_tag="SAVERM_RS11625"
                     /old_locus_tag="SAV_2217"
                     /old_locus_tag="SAVERM_2217"
     CDS             4006..4794
                     /codon_start=1
                     /db_xref="GeneID:41539312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380026.1"
                     /locus_tag="SAVERM_RS11625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2217"
                     /old_locus_tag="SAVERM_2217"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_010983657.1"
                     /transl_table=11
                     /translation="MRRINGTALVIAALFATVGALAYPVWSYADRSGTGQANLAAGTVS
                     TRWGPLTASDRDLIVRVRLAGLWELPAGQQALERPVSKAFKETADHLIVGHTDLDKRVR
                     IVAAQLGVELPNQPNPQQQGWLQELSAASGKEYEYKFANLLRSAHGKIFPAIGAVRNST
                     RNTLVRQLASDTNQTVLDHITMLEKTGSVDFDAIANDTAAAATASPTGPPAPVPGSTAA
                     SAPPAEATGDVQVSSSPSPGEPGTVNTGRPDPEDSDNVLQ"
     misc_feature    complement(4916..4928)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            5001..6446
                     /db_xref="GeneID:41539313"
                     /locus_tag="SAVERM_RS11630"
                     /old_locus_tag="SAV_2218"
                     /old_locus_tag="SAVERM_2218"
     CDS             5001..6446
                     /codon_start=1
                     /db_xref="GeneID:41539313"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999913.1"
                     /locus_tag="SAVERM_RS11630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2218"
                     /old_locus_tag="SAVERM_2218"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_037650004.1"
                     /sec_met_domain="DUF692 (E-value: 1.8e-96, bitscore: 321.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERLRTLGTLGTGIGWRPEIADAVERMPGIDWVEAVAENVCPGHL
                     PESLLRLRARGVTVVPHGVSLGLGGADRPDEGRLAALAERAEALGSPLVTEHIAFVRAG
                     GALTASPLLEAGHLLPVPRTRDALDVLCENVRIAQAALPVPLAVENIAALISWPGEEMT
                     EGQFLYDLVERTGVRLLIDVANLHTNHVNRGEDPAKALDELPVEAIAYVHVAGGFERDG
                     VWHDSHAHPVPQPVLDILADLASRTTPPGVLLERDENFPEPGELERELGAIRKTLEKAG
                     TRAGASAGAAGAATRTAAELTVAESTAVGAIAGPRRGGADAQAAPRAAGTEALSAASTS
                     TPADPARQRLALAQAALLSALVAGTPVPEGFDRVRLGVQARALAAKRADVVAKVAPELP
                     EILAEEYRPAFLTYAPGHPMTGGYRRDALDFAEHLLLAGRPEDAEARRRLRDWWLERSG
                     PTPPSRHPAARLARATRRVLLRR"
     misc_feature    complement(6617..6635)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    6640..6654
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.91"
                     /tool="antismash"
     gene            6824..7591
                     /db_xref="GeneID:41539314"
                     /locus_tag="SAVERM_RS11635"
                     /old_locus_tag="SAV_2219"
                     /old_locus_tag="SAVERM_2219"
     CDS             6824..7591
                     /codon_start=1
                     /db_xref="GeneID:41539314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997027.1"
                     /locus_tag="SAVERM_RS11635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2219"
                     /old_locus_tag="SAVERM_2219"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_010983659.1"
                     /transl_table=11
                     /translation="MRSINHTGLFSGTGLIIAGLTATLVALIFPIWSYADRSGTGLDTL
                     SAQTVSTKFGPLSALDREFVTKVRLAGLWELPAGQQAQDKGTTQAVHTAGEHLVEGHTF
                     LDARVRNVAARLGLELPNQPNPQQRQWLATLNSAQGETYDRDFANILRQAHGKVFSVVA
                     QVRAGTRNSLVRDLADDANTTVLDHIKVLEATGLVDFDALARDAATSGPPPLTSSPAPP
                     GPKASPNSPIPVTPSPTYTLPPAASSPRPSEKN"
     misc_feature    complement(7740..7749)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     gene            7752..8519
                     /db_xref="GeneID:41539315"
                     /locus_tag="SAVERM_RS11640"
                     /old_locus_tag="SAV_2220"
                     /old_locus_tag="SAVERM_2220"
     CDS             7752..8519
                     /codon_start=1
                     /db_xref="GeneID:41539315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432059.1"
                     /locus_tag="SAVERM_RS11640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2220"
                     /old_locus_tag="SAVERM_2220"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_010983660.1"
                     /transl_table=11
                     /translation="MFWVLLLLLAWVAAGTSCTRLCLAAVRAAAVDANAARGHALTLYE
                     AAFLAGGPKRVADLTLVAMARQRRLLLAHTGWATVVDPNGRDEMERSVLGAIGPEGQSR
                     IAPVRRTTAAADPVRSLADRLVTAGLAVPDGARTTVAGAVRQVQAASAAVAALGAVAVL
                     MPAEAAEEQIPVVVWFALPLLLTLSCLAIARVEVHPYTRWASPAGQRLLGALPRHADEA
                     GDDRTYLTSVAVRGIRAIGEPELRAAFTHRERG"
     gene            8566..8784
                     /db_xref="GeneID:43933261"
                     /locus_tag="SAVERM_RS43045"
     CDS             8566..8784
                     /codon_start=1
                     /db_xref="GeneID:43933261"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS43045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_042492952.1"
                     /transl_table=11
                     /translation="MRAAAPCTAAGSLLLTGLAAAPAGGVPAAPGDPELRGTVTVPLDH
                     ARPGGMPAGGCQASPATSSATDLRRPV"
     gene            complement(8733..9464)
                     /db_xref="GeneID:41539317"
                     /gene="hemQ"
                     /locus_tag="SAVERM_RS11650"
                     /old_locus_tag="SAV_2221"
                     /old_locus_tag="SAVERM_2221"
     CDS             complement(8733..9464)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /db_xref="GeneID:41539317"
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564417.1"
                     /locus_tag="SAVERM_RS11650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2221"
                     /old_locus_tag="SAVERM_2221"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_010983661.1"
                     /transl_table=11
                     /translation="MSDDAPTTESGRIPNKGKLAKDLNEVIRYTLWSVFKLKDVLPEDR
                     AGYADEVQELFDQLAAKDVTIRGTYDVSGLRADADLMIWWHAETSDELQEAYNLFRRTK
                     LGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYVSVYPFVRSYDWYLLPDEDRRR
                     MLADHGKMARGYPDVRANTVASFSLGDYEWMLAFEADELYRIVDLMRHLRASEARMHVR
                     EEVPFYTGRRKSVAELVAGLA"
     gene            complement(9469..10935)
                     /db_xref="GeneID:41539318"
                     /gene="hemG"
                     /locus_tag="SAVERM_RS11655"
                     /old_locus_tag="SAV_2222"
                     /old_locus_tag="SAVERM_2222"
     CDS             complement(9469..10935)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539318"
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432062.1"
                     /locus_tag="SAVERM_RS11655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2222"
                     /old_locus_tag="SAVERM_2222"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_062804691.1"
                     /sec_met_domain="DAO (E-value: 2.6e-09, bitscore: 35.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTQTRTGMGQVVVIGGGIAGLAAAHRLLDRGARVTVLEASDRL
                     GGKLLPGEIEGVRVDLGAESMLARRPEAVGLAREVGLADRLRPPATASASIWTRGALRP
                     MPKGHVMGVPGTASALAGVLSDEGLRRIERDADLPRTEVGDDVAVGEYVAARLGREVVD
                     RLVEPLLGGVYAGDAYRLSMRSAVPQLFTAIHAHASLTEVVRELQEKAAAAQQTGPVFM
                     GIEGGVGQLPLAVAESVRARGGEIVTGAPVTELRRAEGGRPRGWLVAGGRVLHADSVVV
                     ALPAAAAAELLRAEAPAAAAELAGVEYASMALVTLAYRRSGTSLPEGSGFLVPPVDGRT
                     IKASTFASQKWGWIADEDPDLLVLRTSVGRYGETEILGRDDAGLVDVSRHDLREATGLA
                     ATPVASRVTRWTDGLPQYPVGHHARVARIRDHVAKLPGLAVCGAAYDGVGIPACIAGAY
                     AAVEQLGGDRAGLDELSAHPVQSLHGGAGE"
     misc_feature    10901..10917
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    complement(11092..11107)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
ORIGIN
        1 gagccgacgg cgcgaccggt accccggcag gcaccggaca cggcaccccg gcctacaccg
       61 gacccggcag cgcgaccgcc accggagccg acggcgcgac cggcatcgaa tccggccccc
      121 gtaccgacac gggcaccgtc cctcgcaccg acaccggcac cggcacgtga cacgtgcgac
      181 gcgcgtggtt ccggtgatcc tgatgccgtg atacacacgg ctgggtcaca gtcctgtccg
      241 ccaacaggaa ggttgcccca tgcccgaaaa cggtcgcccc gcatcgcgac gtcaggtact
      301 ggcccgcagc ggcgcgttgg gcgtctcgat cgccttcgcc ggaaacctct ccgagctctt
      361 cgcgggcacc gccgccgcac aggacctcgg ccaccggggc tatggcccgc tggtccccga
      421 cccgaacggc ctgctcgacc tgccgaaagg tttccgctac cgggtcctgt cccgcgaggg
      481 cgacccgctc cgctccggcg agggcccggt ccccagcaac cacgacggaa tgtcggcgtt
      541 cgcgggccgc cacggccgcg tccacctggt gcgcaaccac gagaaccgcg tcaccgcgaa
      601 gttcccggtc ccgacggtcg agggcctcac ctacgatccg acgggcaagg gcggctgtac
      661 ggcgctgacg ttggacgggc agggccaggt gctctccgaa cgcgtcgcga tcgccggtac
      721 ggcggtcaac tgcgcgggcg ggcccacccc ttggggcacc tggctgacct gcgaggagac
      781 cgaggacagg gccggcacga acggctacac caaggatcac ggcttcatct tcgaggtcga
      841 cccggcgaac ccccaccgca ccggcgccgt accgctcacc gcgatgggcc gcttccagca
      901 cgaggcgatc gccgtcgacc cgagacacgg catcgtctac gagaccgagg acgcgttcct
      961 caagcccttc ggcctcttct accgcttcct gccccaccgg cccgagggcg gcgtcggttc
     1021 attgcgcgcc ggcggccggc ttcaggcgat gcgggtgccc ggcgtacccg acctctcctc
     1081 ggtccaggag acgggcgcgg ccttcgacgg cgtcgagtgg gtggacgtac cggatccact
     1141 ggccgcccaa accccggtca gactccagga cttcggcccg aagggcatca cccacgcaca
     1201 gaagctcgag ggctgctact ggggcggctc gtgcgtgtac ttcgtctcct ccttcgcccg
     1261 cggcgcggac ggctcggccg ctgaccacta cgggcagatc tggcgctacg acccgtccgc
     1321 gcgccggctc accctcgtga tcgtcttcgg cccggacacc gacgtacagc tcccgggcga
     1381 gtcaccggac aacatctgcc tcgcacccgg cggcggtctg atggtctgcg aggacggcaa
     1441 cggcgcgcag cacgtcttcg gggtgacgcg gcgcggcgag gtgtacgccc tggcccgcgg
     1501 cgcccagaac atcggcaccc ccgaggctcc ggagtggggc gagttcgcgg gcgtcacttt
     1561 ctccccggac ggccggacga tgtacgtgaa ctgctacacg cccggtacga ccttcgcggt
     1621 gacggggccc tggcgcaggt gaggtgccct cggcgggccg ggccgcggta cggcacatgc
     1681 cgcccggcgc gctgaccgcc gactcgagtc cgaagccccg gggcaagcgc cccggggctt
     1741 cgtcgtgagg tcgtggggcc cgcttcctcg caccggtacg cccctgacgc acagccggcc
     1801 gggtggcttc gtcgtcgtct tcgcacggca cgtgccctcg gtgggcgaat aatcacattt
     1861 accccgatat ctttatccgg tgatcattct tgtacgccgt gtcgccgtcg ccggtgccct
     1921 gggcgccctg ggagccgcgc tcgccgcctg cggcactccc ggcgcatccg gcaccccgca
     1981 cgccgccgca cgccctgcgc actcggcgcc caccaccgcc gcgtcctcga agccccccac
     2041 cctcacgccc ggcccctccg ggctgacccc cgtcttcaag aacggcccgc gcacgcaggg
     2101 caagaccgtc gcgctcacct tcgacgcgga catgaccgcg gatcagggcg cgcgggccgc
     2161 cgccggggag catttcgaca atccgcagtt gatcggcgca ctgcgcgagc tcaaggtgcc
     2221 ggccaccgtg ttcatgacgg gacggtgggc cgacgaatac ccccaggagg cccgggccat
     2281 cggccgcgac cccctgttcg aggtcgccaa ccactcgtac agccactacg ccttcacaag
     2341 cgactgctac ggcctgccga ccgtgtccga ggaccggatg cggtccgatg tggagcgggc
     2401 gttcgccgcc ttcgagaagg cgggggtgcc ccacgtgatg ccgtacttcc gcttccccgg
     2461 cgggtgctac gaccagcgtg cgctgcgcac gctgatcccc gtcggcgtca ccgcggtgca
     2521 gtgggacgtg gtgagcgggg acgcgttcgc gacggacgcg gacgccgtgg cccagcaggt
     2581 gctggagggc gtccggccgg ggtccgtcgt cgtcatgcac tgcacacgga gcgcggcccc
     2641 gacgacggag cgggccgtac ggacgatcgt tcccgagctg cgcaagaagg ggttccggtt
     2701 cgtgaaggtg tccgagctga tccaagcggc ctcgggcggg cgtcgatagg cggccgaacg
     2761 gcctgtggca gcggttcaca ccgagcggct tacgctggga gcatgagcgg cgactactgc
     2821 ggtacggaga cggcgggccc ggcacccaag gcgggcggtc cgccgttcgc cgcgtgtgtg
     2881 ctgtgccagg agccgacgga gtacccggag tcgtacaagg ggatcacgct gtgccccgtc
     2941 tgcgcgtggc aggaggcaca gcgcggcgcc tgctcaggat gagcgacggg ccgtgcgggg
     3001 agccgcttcc ttcccccacg aagacccgat cttcggcctg gcagactgga gggcgtgacc
     3061 agtgatccca cccccgccac ccccgccacc cccgccaccc cggccgcccc ggccgtcgac
     3121 ggcagcgctc cgcaggacag ccccttccgc tccgagcgca cctcccgtga cgaggcgcgg
     3181 cagttcgtgc tgccgctcgt cgtgcgcatc gagaagtccg ctcccccggc gcgcacggac
     3241 gcgctggaga cggcggcgcg cgcggtgctc gtcatcctga gcgacgagcg gtcgctgggc
     3301 gacggggagt gggcgcaggc gatgacggac tggcaggacg cccggatccg caaggtggtc
     3361 cggcgggcgc gcggcgcgga gtggcggcgg gccgaggccc tgcccgggat cacggtgacg
     3421 ggcaagtcgg cggaggtacg ggtcttcccg ccggtaccgc tggacggctg gcccaaggac
     3481 ctggcccgtc tccaggtctc cggcaccgac ctcgaggatt ttgaaccgcc cctggaggcg
     3541 gacccttccg ccccggtcct ccggctgagc cccgacctcg acatgtcggc gggcaaggcg
     3601 atggcgcagg cgggccacgg cgcccaactc gcctggtggg aactgtcgga cgaggaccgc
     3661 gcggcctggc gcgacgcggg cttcccgctc gccgtccgca cggcggaccc gtcccactgg
     3721 cgcgaactca ccgcctcagg cctcccgttg gtccgcgacg cgggtttcac ggagatcgcc
     3781 cccggctcgt gcacggtggt ggcggaccat ccggcactgc gcggctgacg cctccggagg
     3841 tcacctgacc cggccgctcg ggcggacgcc ggagcggtgg actttgccga gcgaacagaa
     3901 atctttgccc aaggcttgaa catctcgaca gcaccgtacg tacatcccgg cactggccaa
     3961 gcacagacgc ccaacgacca gttggtttca tccgggaggc acactttgcg gcgtatcaac
     4021 ggcaccgccc tcgtcatcgc ggcactcttc gccaccgtcg gcgcgctggc gtaccccgtg
     4081 tggtcgtacg ccgaccgttc cggaaccgga caggcgaacc tcgccgccgg gacggtgagc
     4141 acgcgctggg ggccgctcac cgcctccgac cgcgacctga tcgtccgggt gcgactggcc
     4201 ggcctgtggg agctgccggc cggacagcag gcgctcgagc gcccggtcag caaggcgttc
     4261 aaggagacgg ccgaccacct catcgtcggc cacaccgatc tcgacaagcg ggtccggatc
     4321 gtcgcggccc agctgggagt ggagctgccg aaccagccca acccccagca gcagggctgg
     4381 ctccaggagc tgagcgcggc cagcggcaag gagtacgagt acaagttcgc gaacctgctg
     4441 cggtccgccc acggcaagat cttcccggcc atcggcgccg tccgtaacag cacccgcaac
     4501 accctggtgc gccagctcgc ctcggacacc aaccagaccg tgctcgacca catcacgatg
     4561 ctggagaaga ccgggtccgt cgacttcgac gccatcgcca acgacacggc agccgccgcg
     4621 accgccagcc cgaccggtcc cccggccccg gtccccggtt cgacggcggc ctcggcgccg
     4681 cccgccgagg cgaccggtga cgtgcaggtc tcgtcgtctc cgtcgccggg ggagcctggg
     4741 acggtcaaca cgggccggcc ggatcccgag gactcggaca acgtgttgca gtagcggcat
     4801 cgcgcccggc cccgcggccg ctgcggccgg gcgccggccg ggcatcggcc cggcggaacc
     4861 tcaaatgttc ctctgaacgt ccccggggcg gggttcggcc ccgagggcac gggccatgac
     4921 accgtcacgc cggaacagcg ggcccgtcga gggagacggg gcagcggagt cctggtgaag
     4981 ccgtggtgga ggaggggacg atggagcgac tgaggacact ggggacactg gggacgggga
     5041 tcggctggcg gccggagatc gcggacgccg tggagcggat gccgggcatc gactgggtcg
     5101 aggccgtggc ggagaacgtg tgccccggac atctccccga gtcgctgctg cggctgcggg
     5161 cgcgcggcgt caccgtcgtc ccgcacggtg tctccctcgg cctcggcggg gcggaccgtc
     5221 ccgacgaggg ccggctggcc gccctcgcgg agcgcgccga ggcgctgggc tcgccgctgg
     5281 tcacggagca catcgccttc gtacgcgcgg gcggggcact gaccgcctcg cccctgctgg
     5341 aggcggggca cctgctgccc gttccgcgca cccgcgacgc gctggacgtg ctgtgcgaga
     5401 acgtccgcat cgcgcaggcc gcgctgcccg tgccgctcgc cgtggagaac atcgccgcgc
     5461 tcatctcctg gcccggcgag gagatgacgg aggggcagtt cctgtacgac ctcgtcgagc
     5521 gcaccggcgt acgcctgctg atcgacgtgg cgaacctcca caccaaccac gtcaaccggg
     5581 gcgaggaccc ggccaaggcc ctggacgagc tgcccgtcga ggccatcgcg tacgtccatg
     5641 tcgcgggcgg cttcgagcgc gacggtgtct ggcacgacag ccacgcccac cccgtcccgc
     5701 aaccggtcct cgacatcctg gccgacctcg cctcccgtac gaccccgccg ggcgtactcc
     5761 tggaacgcga cgagaacttc cccgaaccgg gcgagctgga gcgggagttg ggggcgataa
     5821 ggaagacgtt ggagaaggcg gggacgaggg cgggggcttc ggccggagcc gcgggggccg
     5881 cgacgaggac ggcggcggag cttacggtgg cggagtcgac ggcggtcggc gcgatcgccg
     5941 gcccgaggcg tggcggtgcc gacgcgcagg ccgcgcctcg ggcggccggg accgaggccc
     6001 tgagcgcggc gtcgacgtcg acgcccgccg accccgcccg ccagcgcctc gcgctcgccc
     6061 aggccgctct cctctccgcc ctcgtcgccg gcacccccgt acccgagggg ttcgaccggg
     6121 tacggctggg cgtgcaggcc cgtgccctcg ccgccaagcg ggcggacgtg gtcgcgaagg
     6181 tcgcgccgga gttgccggag atcctcgcgg aggagtaccg gccggccttc ctcacgtacg
     6241 cccccgggca cccgatgacc ggcggctacc ggcgtgacgc cctcgacttc gccgagcacc
     6301 tgctgctcgc cgggcgcccc gaggacgcgg aggcccggcg ccggctgcgc gactggtggc
     6361 tggagcgctc cggccccacc ccgccctccc gacaccccgc cgcccgcctg gcccgcgcca
     6421 cccgcagggt cctgctgcgc cgctgaggcc gttgcgtcgc tgaggccgtt gcaccgctga
     6481 ggcgccgttg cgtcgctgag ccctgtgcgc cgcgcggtcc ccggcccggc atcccgaagg
     6541 ccaccggcac gcaggacccc agtacgccca ccgcaacggg acggcaaccg cctccacaga
     6601 atgtgccgcg gttaacatcg cggctccttc gcatgcccac gggattcatt tgcaccgttt
     6661 caccgtggat tgccctccac cgcccctacc gcgtccgggt ccctccgccc cgtaatccac
     6721 cccttcctcc ctgtacggca gttggcgtag tccgcgcagt aatatgccaa gccgcacccg
     6781 aagcgcacta gcgtgcggtg ccgcaagcag gaggcacacc gacatgcgat ccatcaacca
     6841 caccggactg ttcagtggca ccggactcat catcgccggg ctgaccgcga ccctcgtcgc
     6901 gctgatcttt ccgatctggt cgtacgcgga ccgctccggc acaggcctgg acaccctgag
     6961 cgcccagacc gtgtcgacga agttcggccc gctgtccgcc ctggaccggg agttcgtcac
     7021 gaaggtccgg ctggccggcc tgtgggaact gcccgcgggg cagcaggcac aggacaaggg
     7081 caccacccag gccgtgcaca cggcgggcga gcacctcgtc gagggccaca cgttcctcga
     7141 cgcccgggtc cgcaacgtcg ccgcgcgtct ggggctcgag ctgcccaacc agccgaaccc
     7201 acagcagcgt cagtggctcg ccaccctgaa ctcggcgcag ggcgagacct acgaccggga
     7261 cttcgccaac atcctgcgcc aggcccacgg caaggtcttc tccgtcgtcg cccaggtccg
     7321 cgcgggcacc cgcaactccc tggtgcgcga cctcgccgac gacgcgaaca ccaccgtcct
     7381 cgaccacatc aaggtcctcg aggccaccgg cctggtcgac ttcgacgcgc tggcccggga
     7441 cgcggccacc tccggcccgc ccccgctcac cagttccccc gccccgccgg gaccgaaggc
     7501 ctcaccgaac tccccgattc cggtcacccc ctcgccgacc tacaccctgc cgcccgccgc
     7561 ctccagcccc aggccctccg aaaagaactg accagcgccg gaacggcacc aacccgctcc
     7621 cggtacaacg cccgcacgac gcccgtacga cgcccgcacg acgtcaaacg gaacgtcaca
     7681 taccgacaac gctccgtcca tatcgtggaa accccgtggc gctcgggcac ctgttcgcat
     7741 agaaaaacgc catgttctgg gtccttctcc tgctcctggc gtgggtcgcc gccggcacgt
     7801 cctgcacacg cctgtgcctg gccgccgtac gcgccgcggc cgtcgacgcg aacgccgcgc
     7861 gcggccacgc cctgacgctg tacgaggcgg cgttcctggc cggcggcccg aagcgggtgg
     7921 ccgatctgac gctcgtcgcg atggcccgtc agcggcggct gctgctcgcg cacaccggct
     7981 gggcgaccgt cgtggacccc aacgggcggg acgagatgga gcgttcggtg ctgggcgcga
     8041 taggcccgga ggggcagtcg cggatagcgc cggtgcgccg gacgaccgcc gccgccgacc
     8101 ccgtgcgctc gctcgccgac cggctcgtca cggcgggcct cgccgtgccc gacggcgcgc
     8161 gtacgaccgt cgcgggcgcc gtccgccagg tgcaggccgc gtccgcggcc gtcgccgcgc
     8221 tgggcgcggt cgccgtactg atgcccgcgg aggccgccga ggagcagatc ccggtcgtcg
     8281 tctggttcgc gctgcccctg ctcctcacgc tgagctgtct cgccatcgcc cgcgtcgagg
     8341 tccacccgta cacgcgctgg gcgtcgccgg ccggccagcg gctgctcggc gccctgcccc
     8401 ggcacgccga cgaagccggc gacgaccgta cgtatctcac ctccgtcgcc gtacgcggca
     8461 tccgcgcgat cggcgaaccg gagctgcgcg ccgccttcac ccaccgggag cgcggctgac
     8521 ggcccctcac cgatcaacgg ccctcaccga tcaaagggac gcccgatgag agccgccgcc
     8581 ccctgcaccg ccgccgggtc cttgctcctg acgggcctcg ccgccgcacc ggcgggcggc
     8641 gtacccgccg cgccgggcga ccccgaactg cgcggcaccg tcacggtccc gctcgaccac
     8701 gcgcgccccg gcggcatgcc cgctggtggc tgtcaggcga gccccgccac cagctccgcc
     8761 accgacttgc gacgccccgt gtagaacggg acctcctcgc ggacgtgcat acgggcctcg
     8821 gaggcgcgca ggtggcgcat gaggtcgacg atgcggtaca gctcgtcggc ctcgaaggcc
     8881 agcatccact cgtagtcgcc gagggagaac gaggcgaccg tgttggcgcg cacgtccggg
     8941 tagccgcggg ccatcttgcc gtggtcggcg agcatgcggc ggcggtcctc gtcgggcagc
     9001 aggtaccagt cgtaggagcg cacgaagggg tagacgctca cgtagttgcg gggcgtctcg
     9061 tcggcgagga acgccgggat gtgcgagcgg ttgaactcgg cggggcggtg cagcgccatg
     9121 ttcgaccaca ccggctccag ggcgcggccc agcttggtgc ggcggaagag gttgtacgcc
     9181 tcctggagct cgtcgctggt ctcggcgtgc caccagatca tgaggtcggc gtcggcgcgc
     9241 agccccgaca cgtcgtacgt accccggatg gtcacgtcct tggcggcgag ctggtcgaac
     9301 agctcctgga cctcgtccgc gtaacccgcg cggtcctcgg gcagtacgtc cttcagcttg
     9361 aagaccgacc acagggtgta gcggatgacc tcgttgaggt ccttggccag cttgcccttg
     9421 ttcgggatcc tgccggactc ggtggtgggg gcgtcgtcac tcatggggct attctcccgc
     9481 tccgccgtgc aggctctgca ccgggtgggc actcagctcg tccagccccg cgcggtcgcc
     9541 gcccagctgc tccacggcgg cgtacgcgcc ggcgatgcag gccgggatgc cgacgccgtc
     9601 gtacgccgcg ccgcagacgg cgaggccggg cagcttggcg acgtggtcgc ggatgcgggc
     9661 cacgcgcgcg tggtggccga cggggtactg cggcaggccg tcggtccagc gggtgacgcg
     9721 gctggcgacc ggcgtggcgg ccaggccggt cgcctcgcgc aggtcgtggc gcgagacgtc
     9781 cacgaggccg gcgtcgtccc ggccgaggat ctccgtctcg ccgtaccgcc cgaccgacgt
     9841 gcgcagcacc agcaggtcgg ggtcctcgtc cgcgatccag ccccacttct gggaggcgaa
     9901 cgtcgatgcc ttgatggtgc gcccgtcgac gggaggcacg aggaagccgc tgccttcggg
     9961 gaggctggtc ccactgcggc ggtaggcgag ggtgaccagc gccatggacg cgtactcgac
    10021 gccggccagc tcggccgcgg cggcgggtgc ctcggcgcgc agcagctcgg cggcggccgc
    10081 ggcgggcagg gcgacgacca cggagtcggc gtgcagcaca cgaccgccgg cgaccagcca
    10141 cccacgcggc cgcccgccct cggctctgcg cagctcggtc accggcgccc cggtgacgat
    10201 ctcgccgccc cgcgcgcgca ccgactccgc gaccgcgagc ggcagttgcc cgacgccgcc
    10261 ctcgatgccc atgaagaccg ggcccgtctg ctgggccgcg gccgccttct cctggagctc
    10321 gcggaccacc tccgtcagcg acgcgtgcgc gtggatcgcg gtgaagagct gggggaccgc
    10381 cgagcgcatc gagaggcggt acgcgtcgcc cgcgtacacc ccgcccagga ggggctcgac
    10441 caggcggtcg acgacctcgc ggccgaggcg cgccgccacg tactccccca ccgccacgtc
    10501 gtcgccgacc tccgtgcggg gcaggtcggc gtcgcgctcg atgcggcgca ggccctcgtc
    10561 gctcagcacg ccggccagcg cggacgccgt gcccgggacg cccatgacgt ggcccttggg
    10621 catggggcgc agggcgccgc gggtccagat cgacgccgag gcggtggccg gggggcggag
    10681 gcggtcggcg aggcccacct cacgcgcgag gcccaccgcc tcggggcggc gcgcgagcat
    10741 cgactcggcg ccgaggtcga cccggacgcc ctcgatctcg ccgggcagca gcttgccgcc
    10801 gaggcggtcc gacgcctcga gcacggtcac gcgcgcgcca cggtccagca gccggtgcgc
    10861 ggcggccagc cccgcgatcc cgcccccgat gacgacgacc tgccccatac ccgtgcgcgt
    10921 ctgagttgtg ctcatgtccc cactttgtca gacctcactg acagtccggg ccgggggccc
    10981 ggtgacctgg gtgagtccgg accgtgaccg cgccgggacc agtgtcctcg gcgagtcccg
    11041 accgtgatgg catcgggacc ggatccggcc aacgttcctg gcgggccggg cgtcgaagaa
    11101 gcgtcaggca cgacgacttc cgggggtagc ccacatgcag acagcacgca ccgtacgacc
    11161 tgttcgggtc ctggcggccc tgcttttgac ctccgctctc gcgctcgcgg ggtgcagcgc
    11221 cgccgacgac ggcggcggca gcagctcgga cgcgaaggcc gccgctccgg gcgcccaaaa
    11281 aggcgcggcc gacagcggct cggcgagcgg cgccaaggcc tccggcgcgc ccaagctcac
    11341 cgcgagcgcc atcatccgca ccgcctctct gacggtgcag gtcaaggatg tgcccaaggc
    11401 cctcgacgac gcgcgtacga ccgtcgagac ggcgggcggc ttcatc
//
