LOCUS       NC_003155              22446 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2660813
            Orig. end                         :: 2683259
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22446
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="15"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22446
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22446
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12446](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12446)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    422..436
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(555..570)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.67"
                     /tool="antismash"
     gene            1209..3698
                     /db_xref="GeneID:41539284"
                     /locus_tag="SAVERM_RS11480"
                     /old_locus_tag="SAV_2188"
                     /old_locus_tag="SAVERM_2188"
     CDS             1209..3698
                     /codon_start=1
                     /db_xref="GeneID:41539284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006377391.1"
                     /locus_tag="SAVERM_RS11480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2188"
                     /old_locus_tag="SAVERM_2188"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_010983628.1"
                     /transl_table=11
                     /translation="MSRRTGARRRLGSIRLSLILLALLPSVTLAAMWGVTTKQMFSEGL
                     ELRTQTELSMSTGAMGTDATLALQRERSLSAAWLASPGGSRAALDEQRRRTDAAVTRLV
                     GRSDEIEMAPARVGERMYPVMAAAKSLEYYRGQVDDPTDITAKQALDQYTSIIDNQVHA
                     FQELSQVDDGDLTSQAGPLVALEHAAEIVSQEDAQLTLAWPSGKLDEKSWVRFAQLVDA
                     RRWLVQDQLVPSLRGSAKTQTDRILQSPQWQTLEDVEDQVIAARTANGSVARTIELPDA
                     RKRWSAALDQVSAQYANLIQQQTSALLDRSSDKARGLLIKAASLSAGGLAALLLCVVLS
                     WRITRSLSRRLRGLRMATLSLAEERLPDVVARLDRGEKVDVDSATPPLDYGRDELGQVA
                     QAFNTAQRTAVHTAVELADTRRGFQKVILGIARQSQNLVNLQLSKLDELERRHQDPHIL
                     EGLYELDSTASQLRRYEENLVIISGEQPRRSWTEPVALIDILRSAVGEVAEYQRVEVHT
                     DEEVFLTPPAVADVIHLLAELIDNATAYSPAPSPVGVRAAMVAKGLAVEVEDRGLGMSE
                     EDYAALNAQLAVVPQFDVVALADDLRLGMFVIARLATRHGIAVTLRSSPYGGTTAIVLI
                     PHAIVVREASGSPSTKSTDTEPAGSADARTVEPAAAAKGTAGTPDPARQPHERTREARP
                     AARARTAEVPANGAESDTEGVRRTAGRTPRPEPGGVRREGLAPLPRRVPQTSLAAELKE
                     EAAPGREDDDPCEDFTAERAAASLAGFQRGTLQARDTTAEGAYDHREEAAAEDPDARVP
                     APGASSPTLSTPPADRS"
     gene            3710..4141
                     /db_xref="GeneID:41539285"
                     /locus_tag="SAVERM_RS11485"
                     /old_locus_tag="SAV_2189"
                     /old_locus_tag="SAVERM_2189"
     CDS             3710..4141
                     /codon_start=1
                     /db_xref="GeneID:41539285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983629.1"
                     /locus_tag="SAVERM_RS11485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2189"
                     /old_locus_tag="SAVERM_2189"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_010983629.1"
                     /transl_table=11
                     /translation="MTRPTPATHSQLDQLLTGLVDRVAEVDHAVVLSEDGLVVSKSTGF
                     LRDDAERLAATASGLMSLSKGVSMDFRRGPVRQALIEMGKGYLILTAAGPGAHLVVLTR
                     QGADVGVVAYQMNMLVKKIGEHLSAPPRGGAGTAADSGE"
     misc_feature    complement(3744..3759)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.39"
                     /tool="antismash"
     gene            4143..4499
                     /db_xref="GeneID:41539286"
                     /locus_tag="SAVERM_RS11490"
                     /old_locus_tag="SAV_2190"
                     /old_locus_tag="SAVERM_2190"
     CDS             4143..4499
                     /codon_start=1
                     /db_xref="GeneID:41539286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445342.1"
                     /locus_tag="SAVERM_RS11490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2190"
                     /old_locus_tag="SAVERM_2190"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_010983630.1"
                     /transl_table=11
                     /translation="MTDGDAAGRLVRPFTLTGGRTRPSRADFTLITSVTAVERPPAGSF
                     RPQPEHTRILRLCAEPVVVAELAAGLDLPASVVVILLCDLLEAGRITAHPPRLLSRTTD
                     LDLLQKVRDGLGRL"
     gene            4486..5070
                     /db_xref="GeneID:41539287"
                     /locus_tag="SAVERM_RS11495"
                     /old_locus_tag="SAV_2191"
                     /old_locus_tag="SAVERM_2191"
     CDS             4486..5070
                     /codon_start=1
                     /db_xref="GeneID:41539287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326003.1"
                     /locus_tag="SAVERM_RS11495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2191"
                     /old_locus_tag="SAVERM_2191"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_010983631.1"
                     /transl_table=11
                     /translation="MAGSDPAAPAAPAAAAPDTVKILIAGGFGVGKTTMVGSVSEIAPL
                     RTEEPLTAAGLDVDDLDGIAEKDATTVALDFGRITIGSELVLYLFGTPGQQRFWFMWND
                     LAIGALGAVVLIDVRRPESSFAAVDFFERRGIPFVIGVNGFHGLHPYTPEEIREALALP
                     ERAQVLLCDARERESCRDVLIALIDQLIAAR"
     gene            complement(5128..5865)
                     /db_xref="GeneID:41539288"
                     /locus_tag="SAVERM_RS11500"
                     /old_locus_tag="SAV_2192"
                     /old_locus_tag="SAVERM_2192"
     CDS             complement(5128..5865)
                     /codon_start=1
                     /db_xref="GeneID:41539288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996971.1"
                     /locus_tag="SAVERM_RS11500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2192"
                     /old_locus_tag="SAVERM_2192"
                     /product="FAD:protein FMN transferase"
                     /protein_id="WP_010983632.1"
                     /transl_table=11
                     /translation="MRRVEHVMGFPVSLRIDDEGDFDAAADAVFAWLREADARFSPFKA
                     DSEVSRLDRGELREDALSADLLEVLDLCEHYRAATGGAFDVRLPGRGLDPCAVVKGWSV
                     QRAAELLSAAGARRFCLNAGGDVAAAGGPWRVGVRHPEHADKLCTVLELTDGAVATSAR
                     YERGDHIRDGRTGRPATGLLSLTVVAPTLTEADSVATAAFAMGTEGVEWAAGLDGCEVF
                     AVDAERRVLRTAGLPVAGARAAA"
     gene            complement(5867..6286)
                     /db_xref="GeneID:41539289"
                     /locus_tag="SAVERM_RS11505"
                     /old_locus_tag="SAV_2193"
                     /old_locus_tag="SAVERM_2193"
     CDS             complement(5867..6286)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996970.1"
                     /locus_tag="SAVERM_RS11505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2193"
                     /old_locus_tag="SAVERM_2193"
                     /product="FMN-binding protein"
                     /protein_id="WP_010983633.1"
                     /transl_table=11
                     /translation="MKRALPVLVLSVAGLIPLWRYEPSTDTTSTTQTAPPAASPSASSS
                     PGSSPGSSAQVVAGSTVKTEKGPVQVEVTFEGDTISAVRMLRQPNHPQTTAAVPKLVAE
                     TLKAQSADIDTVSGATVTSDGYKESLQAALDAKGA"
     gene            complement(6306..7643)
                     /db_xref="GeneID:41539290"
                     /locus_tag="SAVERM_RS11510"
                     /old_locus_tag="SAV_2194"
                     /old_locus_tag="SAVERM_2194"
     CDS             complement(6306..7643)
                     /codon_start=1
                     /db_xref="GeneID:41539290"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122095.1"
                     /locus_tag="SAVERM_RS11510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2194"
                     /old_locus_tag="SAVERM_2194"
                     /product="ferredoxin reductase family protein"
                     /protein_id="WP_037650069.1"
                     /transl_table=11
                     /translation="MTTVQSPPAPPTAIRPRVVARAGLYAVLAANAAVVAFLFAQAGFA
                     SNALIVLGRLAGLYGALLMAFQLLLVARLPWLDRRIGMDRLTSWHRWTGFGILWTLLAH
                     AVFITFGYAQSSSMDPVNQLVDLAETVEGVLRAVVALTIIVVVGAVSGRYARRRLAYET
                     WHFIHLYTYVAVVLAFTHQVAAGTTFTSSSAATAYWYAVWGVALGSVLVGRLVLPLWRN
                     WRHQLRVTAVVPESDNVVSIHISGRDLDRMPARAGQFFLWRFLTRDRWWQANPFSLSAA
                     PDGTRLRLTAKTAGDGTAALRHVKVGTRVFAEGPYGAFTAMHRTRPESLLVAGGVGVTP
                     IRALLEDLEGHAVVIYRVAEDRDAVLYDELRELAHAKGAELHLVTGPAAPDRLAPSELA
                     RLVPDIAERDVFLCGPPGMTTTLLRTLRELGVPKQQIHHERFSLAG"
     misc_feature    complement(7793..7809)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.63"
                     /tool="antismash"
     gene            7795..8538
                     /db_xref="GeneID:41539291"
                     /locus_tag="SAVERM_RS11515"
                     /old_locus_tag="SAV_2195"
                     /old_locus_tag="SAVERM_2195"
     CDS             7795..8538
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539291"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996968.1"
                     /locus_tag="SAVERM_RS11515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2195"
                     /old_locus_tag="SAVERM_2195"
                     /product="response regulator transcription factor"
                     /protein_id="WP_242432234.1"
                     /transl_table=11
                     /translation="MEKVRLLVVDDDPPIADLVATVARYEGWDAVTAYSGEEALRLAAE
                     FPPDIVVLDLMLPDIDGFGVLDRLRRSGTMVPVVFLTARDTVADRVAGLTRGGDDYLVK
                     PFAVEELMARLRTVLRRSAGPGFQRSVLRVADLTMDEDTRQVRRGDRLLTLTPTEYEVL
                     RYLMRKSPAVLTKAQILDHVWEYGFGGRSNVVELVVSRLRRKLDEADAADAGDVAAEDS
                     AADAGREPLIHTVRGFGYVIRPAAR"
     gene            8535..9971
                     /db_xref="GeneID:41539292"
                     /locus_tag="SAVERM_RS11520"
                     /old_locus_tag="SAV_2196"
                     /old_locus_tag="SAVERM_2196"
     CDS             8535..9971
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539292"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062824.1"
                     /locus_tag="SAVERM_RS11520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2196"
                     /old_locus_tag="SAVERM_2196"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_010983636.1"
                     /transl_table=11
                     /translation="MTGRLRRTYRRLRLGTRLALGLGVLSLVVFAVVGTALTTYMRDYL
                     EAQLGDQMKLVQVLQSKDAQVHGVVQRQPYYGWYTAVYDVSGDSAVLRRPADVPADTRA
                     LTALAETMAHSDTDLRRTVRIDGKGTYRLQACEVEPGVVLVSAAPMADVQATVRQLITV
                     QVVAFVLALLALVVFGRAMLRRGLKPLSDMAHTAHGIASHNLTGSAARLPLRDDGRSGG
                     PEVEELRTAFNTMLEHIDGSLAVRAEAEQRLRRFVADASHELRTPLMSVRGYADLFQYA
                     AANAPGERDRHLARLRAEAARMGLLLDDLLLLARLDAAEVETPLRMEDADLVELVRQAA
                     DAFRAGHPDRPLTVTTGPDAVPLRLDPLRIRQVLDNLLTNAAVHTPAGTEVSVEVSVSS
                     GTAWVGVADSGPGVPAADRERVFDRFYRVDKARSRDRGGSGLGLAVARSLVRAHGGTVA
                     LTGEPGATVFTLGIPLGRRD"
     gene            complement(10001..11818)
                     /db_xref="GeneID:41539293"
                     /locus_tag="SAVERM_RS11525"
                     /old_locus_tag="SAV_2197"
                     /old_locus_tag="SAVERM_2197"
     CDS             complement(10001..11818)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539293"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677081.1"
                     /locus_tag="SAVERM_RS11525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2197"
                     /old_locus_tag="SAVERM_2197"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_037650016.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.1e-23, bitscore:
                     80.9, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEALRLEWAAGAPRLRATEAMARQGLVTTVSSRAGTAVVVGWAGS
                     VRDRVAGAHGLLDDFGRPGAAPRLPAGDYAAVLVCRDRVLLMRDEQARIPLFFRESGGQ
                     VSAVSTSARRLGDFEELERRYFCRYLTGNMAQPHSELTPFAGVHRVLGGEVVELSITGR
                     MRGRALGRVGHADHPWDSTADGLRLSGAAKELRLALEHAVGRRMGTMTACHVSGGTDST
                     SVALLAARPTAAGQDSPRDLVLLAGRFGTGELAGEQPYLDEAMKEIHRHAPGARPVMVD
                     VGDVADFDDFQDHAGDADEPHAHAFRAPFWSRLHAAAAELGCDILLTGCGADAMVDANP
                     FHLHRLARTGQLRQLTKQARAWAAGSERGVRDVVCDYVMRPALPLTAERITALVRRGTV
                     LGGLGSFTRPRWLRPGFARAHGYREAGIAESRFVFGRRPEQSLFEAANYLAAPDPLSWR
                     RARQDGFFLSHPFLDHEVIATMRSLPPEATFRPGRPKAVLREAMADLLPSRIRGRAVKV
                     PFDELYARGLRRHGDELIDLCRSARHPLVAEMFDVETLCRAVREAQLGVGDAYSWDRMN
                     SSLALVVWLERLDRRGCAGGAGMPVIAGS"
     gene            complement(11820..12446)
                     /db_xref="GeneID:41545052"
                     /locus_tag="SAVERM_RS41440"
                     /old_locus_tag="SAV_2198"
                     /old_locus_tag="SAVERM_2198"
     CDS             complement(11820..12446)
                     /codon_start=1
                     /db_xref="GeneID:41545052"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988888.1"
                     /locus_tag="SAVERM_RS41440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2198"
                     /old_locus_tag="SAVERM_2198"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_010983638.1"
                     /sec_met_domain="PF13471 (E-value: 2e-19, bitscore: 68.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEETDALAAMTRILSPHCRVTRMSGGALIADWRRRTRFLGMTAT
                     DMRKFADGSSEERAELVTGLIRAGCATARRKGHSDVEVGLWLRGVHLLIRTLGFGRVLR
                     LLSLAAPVYARADPPSAEDVERLKRAVRSHSRSSWFVNDDCKTEAVTAFVLLRRCGLKA
                     VLHVGVREHPFALHAWTSSAGLCIPDADPRGHAFAPVLSISCAGQ"
     misc_feature    12682..12698
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            complement(12846..16670)
                     /db_xref="GeneID:41539294"
                     /locus_tag="SAVERM_RS11535"
                     /old_locus_tag="SAV_2199"
                     /old_locus_tag="SAVERM_2199"
     CDS             complement(12846..16670)
                     /codon_start=1
                     /db_xref="GeneID:41539294"
                     /inference="COORDINATES: protein motif:HMM:NF012234.4"
                     /locus_tag="SAVERM_RS11535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2199"
                     /old_locus_tag="SAVERM_2199"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_037650014.1"
                     /transl_table=11
                     /translation="MDVRHDTGSGDDAAPTDGTPLPAPRRPVRRPAAARTTFHRDRRTV
                     RKRLWAASGAGVGAVVCWVSADAVHAVRAPVPVVAECVLGGAVLAVVCVRLLLTSLWPV
                     ALTVDIDGIEWHGPLRRLRWSWPELDWLCVVPAVDRRILRTGHRFPEQLLLRTTPPATA
                     PATAPTTPPTPSPLTAPATAPGPRRRITGPAGLLLRTVELTPRWDAGWRCVSVDLRPLA
                     VEPRELDLALDTHAGPRWRRTGLPPATTSAVATGSEYRIPGRLRSPLTRRAAGYGGRLS
                     VAVWLACCYGYLRFAATRPGPGLHWAYLGAGLAAPAVVLPALLALDHLLARRCALHLDA
                     GGLRLHAGGTDRALPWSAVESLEIGSAPEGARGRQHRWALLARPLVPEPGAAPPRDCFR
                     AAPDGTLRIVPVLAGVPGEALGLAVHPGQLAHALHTFGVRVAGPARDGDGAQRWSAPAL
                     DAAVPPADPPSAPPSGTRSAAPGELRVLRVSPTGDSGHRTIAAALRAHTGPGPLRVMVE
                     PGRYPEPLSLKGEVELCAARGPGTVVVEPAVAGANVLDVTGSAVVTGLAVVGRGTATVA
                     VFGRLLLRDCRLEGRDGAAALTASAGSEITVMGGELAVGKATLQGARAVLRGTRFQAAG
                     EDALVVSQGAHAEVTDCVFADGRGSAVHVSGAGTRARLRTCEFSGFGGHGVLVEQQAEA
                     EVRDCLLRDLSGTALGFRDQGHGTVVGTRVRGADAGAVVSGGADPTLRDCSFHGCRAVG
                     VRVTEEAVCGIEDCSFEHLSNAALSVDQKARLRVNGCRIVDARHGVVVEKGHASLERVE
                     ARALTGSVVRLCQDGTFEAAELRADDCKYGLHASGSGSSGELTGAELCGMRDCALVLTG
                     SARVVARNLRISEPVSDGLFARDTSYLTVRQCTVERAARYGAHILDSAVLVADQLTVTD
                     SGAHGILAENSSQFDIRDSSCTGSDGDGLRTRSDVSGRITDSRITGSRGEAVAGDGSVR
                     LDAVTTRDAPPPAGQPAAGLGPQAELDALIGLTEAKRQVRTQVDLLRLARLRRDAGLSE
                     PPGGRHLVFSGPPGTGKTTVARLYGRILAELGVLSDGRLVEVHRSDLVGQYLGSTALKT
                     RAVFDSARGGVLFIDEAYSLARRFGVNHDLGQEAIDELTKLMEDHREDVVVIAAGYPVE
                     MEGFLEANPGLASRFSRIVTFSPYSPGELVRIVRHLADRHGFELDPDVEPRLLARFRGR
                     ASTGSPSNGRDARTLFETMIEHMAGRLSDIDRPTHQELLTLRPDDIPEP"
     gene            16766..17164
                     /db_xref="GeneID:41539295"
                     /locus_tag="SAVERM_RS11540"
                     /old_locus_tag="SAV_2200"
                     /old_locus_tag="SAVERM_2200"
     CDS             16766..17164
                     /codon_start=1
                     /db_xref="GeneID:41539295"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS11540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_2200"
                     /old_locus_tag="SAVERM_2200"
                     /product="hypothetical protein"
                     /protein_id="WP_037650012.1"
                     /transl_table=11
                     /translation="MSDVSSHEDHDRQLALLCQQLARLRRMHRGPVGASGRLVIDRAVR
                     AAREGGPIGEHLEALGLLPGRTADEADEGAPRGTTLPPRVTDGAPHALLGQHVCPRGVC
                     TRREQRAVGEERPVCEIFDLALRFDPER"
     misc_feature    16780..16795
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            17175..18104
                     /db_xref="GeneID:41539296"
                     /locus_tag="SAVERM_RS11545"
                     /old_locus_tag="SAV_2201"
                     /old_locus_tag="SAVERM_2201"
     CDS             17175..18104
                     /codon_start=1
                     /db_xref="GeneID:41539296"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS11545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_2201"
                     /old_locus_tag="SAVERM_2201"
                     /product="hypothetical protein"
                     /protein_id="WP_010983641.1"
                     /transl_table=11
                     /translation="MLSGFVTDVGRKLAERWAATLVLPGLLFTTVAAVALTLRQSAWSD
                     VDLLRLRVTALTGAGSGAGPGAGSGSTRTAVLLLGVLAASFAAALVADALGGPYEQALL
                     GSWPRLLSRPAAALTGRRRRIWQERDDACRRAVAQDTEGAAERAARLGALEVLRNQVAL
                     TRPECPTWIGDRLRAPAVRIRLEYRLELSDAWPRLWLVLPDSTRQPLAEARQRLDEAMR
                     LGGWAVLYLLLGAVWWPSAVAGAGAALVAWRRGRDRAEEYAELVESAVDVHLQELFERF
                     DEEARPVRASLGPAVTERFRKGAGPRRP"
     gene            18250..22011
                     /db_xref="GeneID:41539297"
                     /locus_tag="SAVERM_RS11550"
                     /old_locus_tag="SAV_2202"
                     /old_locus_tag="SAVERM_2202"
     CDS             18250..22011
                     /codon_start=1
                     /db_xref="GeneID:41539297"
                     /inference="COORDINATES: protein motif:HMM:NF024180.4"
                     /locus_tag="SAVERM_RS11550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2202"
                     /old_locus_tag="SAVERM_2202"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_137951398.1"
                     /transl_table=11
                     /translation="MTEPQQLPGEDRPAERERLLRAVRGRLDALGGPTGNGHLHTAEAR
                     QETDRLLRHLVAPHPATGGGHALDAEVAYVLGVMYLFVADDRPDAPTAAQDGQCALLLL
                     APFYCHLPDQPDVLPPPLRAGLDQLLGAEGRRPDAPEEIVQEHAASLANLAMLLLELGI
                     TLAYPEAIRVAADLAREALPHLSPDGHDRALAGCNLGYALLLSGPTPVSSPGQADPEQL
                     AEAVSVLRTAFAATPREHPNHARCANGLGLALLASAGQAEDRTQLAEAAAMLRIATQTA
                     TEVDQNLPQMYSDLGYTLTLCARTAGEGEEPGPEVREEAVDALRRAVDLTTPAEDGEML
                     RTRLDRLADAVVIGSPSDDRPRAAAQAEQAVDTLRRLLDLTPEGHPERGDVLLRLAGNR
                     LVAQHPQETIDLLVQGESAYATDPRREQIARALLVEAAMLKGELDSRADLTPEQQADWQ
                     AIDDVMLPLLSGDTTGHPMRSVMNLIGLGGEGGGSRSQELMDFGSMVLGYPDRVGLNEI
                     FAKAMELQARRIARLPEEERAGAVAAFLAGDDDEGAPGPPGGRVEESEEPPDTSSLDEL
                     LEIHERLLPRLPPDSREHRLLHGGRNMLRLVQIMYESMYAPGDTRTRLQLMRRALPLMR
                     ELFEELPAQLEELGIKPELFGAHTALAFAYESPFEQLEAVEEGVRAARRRLTELAPDTP
                     EYAETRTTLALSLFVRHALWSEEADYEEAVGIARELTSAPAPGWRTAMLLTQWTSAAQS
                     RIQRTGLLGQAPPGVGQSPSLITRLASDGAATALDDRDPVEALETLEDGRAHLLSGALN
                     ARRELEVLHGADAKLHGRLRAALERIRALRTAREPGRWPTPDEEDELRSASDDAAWLVA
                     ELQQHPGFQRFLTPLPLGLDDLLPAAAEGPVVSVNINPRRCDALALCPDGLRAVPLPRL
                     YASDLVAQAESFRVAVEALTAGPRDPLFEDAREIFTGTLAWLWDVLAEPVLDALGFTGP
                     PESGAPWPRLWWSPSGVLNSFPLHAAGRHGSGEAADAAVLDRVASSYTPTLRALLFSRA
                     RRRAAPGRRRTLAVAMPQTAGQAPLARTVTEATEAVAAGGGVPLIGPAATRDSVRAAMV
                     DAAVVHFACHADSDPEDLSAGRLLLADGDLLIRDIAELHLETAELAYLSACGTARGGAT
                     AALADEVIHLGSAFQLAGYAQSVATLWEVGDSFAARAAAEFHRTLAPSLPGPGPLPAAL
                     ALHHTVRSLRQDDRERPWTWSALVHAGA"
     misc_feature    complement(22110..22119)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.35"
                     /tool="antismash"
     misc_feature    complement(22130..22141)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     regulatory      22173..22353
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
ORIGIN
        1 ccgcccgggg cgcggccctg gccgccggcg cggtcgccgt ctgcctgctc gcggccggct
       61 gctccgcttc cgacgggtcg gacgccggca ccgaagcggc gggccgggcg ggcaccgccc
      121 ggatcaaggt ggccctggtg acccacggcg agcgcggcga cgccttctgg gacctggtgc
      181 gcaagggcgc tcagacggcg gccgccaagg acggcatcga gctgacctac gtcagcgacg
      241 ccacgggggc gggacaggcg gagctgctgc gggacgcggt ccgcgaccgg gtcgacggca
      301 tcgcggtgac cctggccaag ccggaggcga tgaagggcgc ggtcgccgac gccatggccg
      361 ccggcatacc gatggtcggc ctcaactccg gtatcgacga ctggcgttcc tacggcctgc
      421 tcgagtactt cggccaggac gagagcctca cgggccgtgc gctcggcgac aagctggacg
      481 ccctgcacgc ccagcacgcc ctgtgtgtca tccacgagca gggcaatgtg gcgctggagg
      541 cgcgctgcgc cggggtgaag aagacgttcg gcggccggac ggagatgctg tacgtggacg
      601 gcgccgaccc gaaggcggtg accgcctccg tcacggcccg gctgcggcag gacccgagca
      661 tcgacgaagt cgtcacgaac ggggcggaga tcggcctcga ggcggtgaag tcggtgaaga
      721 gcgcgggcag caaggccagg atcgccacct tcgacctcag caagaacgtg gtcaaggccg
      781 tgcagcgcgg ggatgtgcag ttcgcggtcg accaacagcc ctatctccag ggctatctcg
      841 ccgtggactc gctgtggctc taccggtcca acggcaatct cagcggcggc ggagaggctc
      901 ccgtgctgac cggccccgcc ttcgtcacca aggagaacgt cgccgaggtc gcgaagtacg
      961 cggccgacgg aacccgctga gcggcgccgt cgtaccccgg cgtcgccaag gttttcgctc
     1021 cctcacggtg cgtacggtca cttgtacgga tagcatcctg cgcaccccct gtgccgtacc
     1081 ggccacgcgg tcacccaccg cactgcgccc acggtcccct ttcccgccgc cccgtcaccc
     1141 gctgtccccc tccccgctgc ccctccccgc tgcccccttc cgctcaccgc tcatcggcta
     1201 ggacgacgat gtctcgacga acaggtgccc ggcgccgcct cggctccata cgtctctcgc
     1261 tgatcctgct ggcgctgctc cccagcgtca ccctcgccgc catgtggggt gtgacgacga
     1321 agcagatgtt ctcggagggt ctggagttgc ggacgcagac cgagctgagc atgtcgaccg
     1381 gggccatggg gaccgacgcg acgctcgcgc tgcaacggga gcggagtctg tcggccgcct
     1441 ggctggcctc gcccggcggt tccagagccg ccctggacga gcagcggcga cggacggacg
     1501 cggcggtcac ccggctggtc ggccggtccg acgagatcga gatggccccg gcccgggtcg
     1561 gggaacggat gtacccggtc atggccgcgg cgaagagcct ggagtactac cggggccagg
     1621 tggacgaccc gaccgacatc accgccaagc aggccctgga ccagtacacc tcgatcatcg
     1681 acaaccaggt ccacgccttc caggagctct cccaggtcga cgacggggat ctcacctcgc
     1741 aggccggccc gctcgtcgcg ctggaacacg ccgcggagat cgtctcccag gaggacgccc
     1801 agctgacgct ggcctggccg tcgggaaagc tcgacgagaa gtcgtgggtc cgcttcgcgc
     1861 aactggtcga cgcccggcgc tggctcgtcc aggaccagct cgtcccctcg ctgcgcggca
     1921 gcgcgaagac gcagacggac cggatcctgc agagtccgca atggcagacc ctggaggacg
     1981 tcgaggacca ggtcatcgcg gcccggacgg cgaacggcag cgtcgcgcgg accatcgagc
     2041 tgccggacgc gcgaaagcgc tggagcgccg cgctggacca agtctccgcg cagtacgcga
     2101 acctgatcca acagcagacc tcggccctgc tcgaccgcag cagtgacaag gcccgcggac
     2161 tgctgatcaa ggcggcctcg ctgagcgccg gcggactcgc cgccctgctg ctgtgcgtcg
     2221 tactgtcctg gcgcatcacc cgctccctgt cccggcggct gcgggggctg cggatggcca
     2281 cgctcagcct ggccgaggag cggctgcccg atgtggtcgc ccggctcgac cggggcgaga
     2341 aggtcgacgt ggactccgcc acaccgccgc tggactacgg cagggacgaa ctcggccagg
     2401 tggcccaggc gttcaacacc gcgcagcgca cggcggtcca caccgcggtg gaactcgccg
     2461 acacccgacg cggcttccag aaggtcatcc tgggcatcgc ccggcagagc cagaacctgg
     2521 tcaacctcca gctcagcaag ctcgacgaac tggaacgccg gcaccaggac ccgcacatcc
     2581 tggagggcct gtacgaactc gactccaccg cgagtcagct ccgccgctac gaggagaacc
     2641 tcgtcatcat cagcggcgaa cagccccggc gcagctggac cgagccggtc gccctgatcg
     2701 acatcctgcg cagcgccgtc ggcgaggtcg ccgagtacca gcgggtggag gtgcacaccg
     2761 acgaagaggt gttcctgacc ccgcccgcgg tggccgacgt catccatctg ctggccgaac
     2821 tcatcgacaa cgccaccgcg tactcccccg cgcccagccc ggtgggcgtg cgggccgcga
     2881 tggtggccaa ggggctggcc gtcgaggtcg aggaccgcgg tctcggcatg tccgaggagg
     2941 actacgcggc cctcaacgcc cagctcgcgg tggtcccgca gttcgacgtg gtggccctgg
     3001 ccgacgacct ccggctcggc atgttcgtga tcgcccggct cgccacccgg cacggcatcg
     3061 ccgtcaccct gcgttcctcg ccgtacggag ggaccaccgc gatcgtgctg atcccgcacg
     3121 ccatcgtggt gcgcgaggcc tccggctccc cgtccacgaa gtccacggac accgaaccgg
     3181 ccggctccgc cgacgcacgg accgtcgaac cggccgcagc ggcgaagggc accgccggca
     3241 ccccggatcc ggcccgccaa ccccacgaac gcacgcggga ggcgcggccg gccgcgcggg
     3301 cccggacggc cgaagtcccc gcgaacggag cggagtcgga caccgaaggg gtacgcagga
     3361 cggcgggccg cacgccccgc cccgaacccg gtggcgtacg ccgcgaggga ctcgctccgc
     3421 tgccgcggcg ggtgccgcag accagcctgg ccgccgagct gaaggaggag gccgcgcccg
     3481 gccgggagga cgacgacccc tgcgaggact tcaccgcgga gcgtgccgcc gcctcgctcg
     3541 ccggtttcca gcgcggaacg ctccaggccc gggacaccac cgccgagggg gcgtacgacc
     3601 accgggagga agccgccgcc gaagacccgg acgcccgggt tcccgccccg ggcgcatcgt
     3661 cccccacgct ctcgactccg cccgcagacc gctcatgaag gacagggaaa tgacacgccc
     3721 cacccccgcc acgcacagcc agctcgacca gttgctcacc ggactggtcg accgggtcgc
     3781 cgaggtggac cacgccgtcg tgctctccga ggacggactg gtcgtcagca agtccaccgg
     3841 gttcctgcgc gacgacgccg agcggctcgc ggcgaccgcc tccgggctga tgagcctcag
     3901 caagggcgtc agcatggact tccgccgtgg cccggtgcgt caggcgctca tcgagatggg
     3961 caagggctat ctgatcctca ccgccgccgg ccccggcgcc catctcgtcg tcctcaccag
     4021 acagggcgcg gacgtgggtg tggtggcgta ccagatgaac atgctggtga agaagatcgg
     4081 cgagcacctc agcgcgccac cgcgtggggg cgcgggcacc gcggccgaca gcggcgagtg
     4141 aggtgacgga tggcgacgcg gctggtcgtc tggtgcggcc gttcacgctg accggtggcc
     4201 ggacccggcc cagccgggcc gacttcaccc tcatcacgtc ggtgaccgcg gtggaacggc
     4261 cgcccgccgg gagcttccgt ccgcagcccg agcacacccg gatcctgcgg ctgtgcgcgg
     4321 agccggtcgt ggtggcggaa ctcgccgccg ggctcgacct tccggcgagc gtggtcgtca
     4381 tcctgctctg cgacctgctg gaggcgggcc ggatcaccgc ccacccgccg cgcctcctct
     4441 cccgcaccac ggacctggac ctgctgcaga aagtgaggga cggccttggc cggctctgac
     4501 cccgccgcac ctgccgcccc cgcggccgcg gcacccgaca cggtcaagat cctgatcgcc
     4561 ggcggattcg gcgtcggcaa gacgaccatg gtcggttccg tcagcgagat cgcgccgctg
     4621 cggaccgagg aaccgctgac cgccgccggc ctggacgtcg acgacctcga cggcatcgcg
     4681 gagaaggacg ccaccaccgt ggccctcgac ttcggccgga tcacgatcgg ctcggaactc
     4741 gtgctgtatc tcttcggcac ccccggacag cagcggttct ggttcatgtg gaacgacctg
     4801 gccatcgggg ccctgggcgc ggtggtcctc atcgatgtgc gcaggccgga gtccagcttc
     4861 gccgccgtcg acttcttcga gcggcggggc atcccgttcg tcatcggcgt caacggtttc
     4921 cacggactgc atccgtacac gcccgaggag atccgggagg ccctggccct gccggagcgg
     4981 gcccaggtgc tgctgtgcga cgcacgggag cgcgagtcgt gccgggacgt actgatcgcc
     5041 ctgatcgacc agttgatcgc cgcccgctga cgtggccgag ccggcccgtc gcggggccct
     5101 ggcggccggg cgggggtccg ccccgggcta tgcggccgcc cgcgccccgg ccaccggaag
     5161 tcccgccgta cgcaggaccc gacgctcggc gtccacggcg aacacctcgc agccgtccag
     5221 cccggcggcc cactcgacgc cctccgtgcc catcgcgaag gccgccgtcg cgaccgagtc
     5281 cgcctcggtc agtgtcggcg ccacgaccgt caggctgagc aggccggtcg ccggtcgccc
     5341 ggtgcgcccg tcgcggatgt ggtcgccgcg ttcgtagcgc gcggaggtcg cgaccgcccc
     5401 gtcggtgagc tccaggaccg tgcacagctt gtcggcgtgt tcgggatgcc gtacgcccac
     5461 ccgccaggga ccgccggcgg cggccacgtc accgccggcg ttcaggcaga acctccgcgc
     5521 ccccgccgcc gacagcagct ccgccgcccg ctgcaccgac cagcccttga ccaccgcgca
     5581 ggggtccagg ccacggccgg gcagccgcac gtcgaaggct ccgccggtgg cggcccggta
     5641 gtgctcgcac aggtcgagga cctccagcag atccgcgctg agcgcgtcct cgcgcagctc
     5701 gccccggtcc agccgggaca cctcgctgtc ggccttgaag gggctgaacc gcgcgtcggc
     5761 ctcccgcagc caggcgaaca ccgcgtccgc ggccgcgtcg aagtcgccct cgtcgtcgat
     5821 ccgcagcgag accgggaacc ccatgacgtg ttcgacgcgc cgcacctcag gcgcccttcg
     5881 cgtcgagggc ggcctggagc gactccttgt acccgtcgct ggtgacggtc gcgccggaca
     5941 ccgtgtcgat gtccgcgctc tgcgccttca gcgtctccgc gaccagcttc ggcaccgccg
     6001 ccgtcgtctg cggatggttc ggctgccgca acatccgcac ggcgctgatc gtgtcgccct
     6061 cgaaggtcac ctcgacctgc acggggccct tctcggtctt gacggtcgac cccgcgacga
     6121 cctgggccga agaacccggc gaagaacccg gcgaggagga cgcggaaggc gacgcggcgg
     6181 gcggggcggt ctgggtggtg gacgtcgtgt cggtcgacgg ttcgtagcgc cacagcggga
     6241 tcaggcccgc gacgctcagg accaggacag gaagtgctcg tttcaccggg atttcctcgt
     6301 ctccctcatc cggccaggct gaagcgctcg tggtggatct gctgcttggg cacgcccagc
     6361 tcgcgcaggg tgcgcagcag ggtggtggtc atcccgggcg gtccgcacag gaagacgtcc
     6421 cgctcggcga tgtccggtac caggcgggcg agttcgctcg gggccagcct gtcgggggcg
     6481 gccggcccgg tcaccaggtg gagttcggcg cccttggcgt gggcgagttc ccgcagctcg
     6541 tcgtagagga cggcgtcgcg gtcctcggcc acccggtaga tgaccaccgc gtggccttcc
     6601 aggtcctcca gcagcgcccg gatgggtgtg acgcccaccc cgccggcgac gagcagggac
     6661 tccggacgcg tgcggtgcat cgcggtgaag gcgccgtacg gcccctcggc gaagacccgc
     6721 gtgcccacct tcacatgccg cagggccgcg gtgccgtcgc cggccgtctt cgcggtgagc
     6781 cgcagccgcg tgccgtcggg ggcggccgac agcgagaagg ggttggcctg ccaccagcgg
     6841 tcccgggtca ggaaccgcca caggaagaac tggcccgccc gcgcgggcat ccggtccagg
     6901 tcgcggccgg agatgtggat cgagacgacg ttgtcggact ccgggaccac ggccgtgacc
     6961 cgcagttggt gacgccagtt ccgccacaac gggagcacca gccggcccac gagcaccgag
     7021 ccgagcgcga cgccccacac ggcgtaccag tacgccgtgg cggcggacga cgaggtgaag
     7081 gtcgtaccgg ccgcgacctg gtgcgtgaac gcgagcacca cggcgacgta ggtgtacagg
     7141 tggatgaagt gccatgtctc gtaggccagt cggcgccggg cgtaccggcc ggagacggca
     7201 cccacgacga cgatgatcgt cagggcgacg accgcgcgga gcacgccctc gacggtctcg
     7261 gcgaggtcca ccagctggtt caccggatcc atcgacgacg actgtgcgta accgaaggtg
     7321 atgaagacgg cgtgcgcgag cagcgtccac aggatgccga agccggtcca gcggtgccag
     7381 ctggtcagcc ggtccatgcc gatccggcgg tcgagccacg gcagccgggc caccagcagc
     7441 agctgaaagg ccatcaggag ggcgccgtac aggccggcca gccggcccag cacgatcagc
     7501 gcgttcgagg cgaacccggc ctgggcgaag aggaaggcca ccacggccgc gttcgcggcc
     7561 agcacggcgt acaggcccgc gcgggccacc accctggggc gtatcgccgt ggggggcgca
     7621 gggggcgatt ggacggtcgt cacggacggc agctccttga tcgggtcctg ggacaccgag
     7681 cttcgctggc gagagctgtc gttttcctgt cgccggactt tcaactgctt atcgatatgg
     7741 gtccgggggg tggcccgctc tggcgccctg ggacacgtga agcactatga gcaggtggaa
     7801 aaagtacgac tcctcgtcgt ggacgacgac ccgcccatcg ccgacctcgt ggcgacggtc
     7861 gcccgttacg agggctggga cgcggtcacc gcgtactcgg gcgaggaggc gctgcgcctg
     7921 gccgcggagt tccctccgga catcgtggtg ctcgatctga tgctgcccga catcgacggg
     7981 ttcggcgtcc tcgaccggct gcgtcggtcc gggacgatgg tgcccgtcgt gttcctcacc
     8041 gcccgggaca cggtggccga ccgggtcgcg ggcctgacca ggggcggcga cgactatctg
     8101 gtcaagccgt tcgcggtgga ggagttgatg gcccggctgc ggaccgtgct gcgccgcagc
     8161 gccggacccg gtttccagcg gtccgtgctc cgggtggccg acctgacgat ggacgaggac
     8221 acccgtcagg tgcggcgggg cgaccggctg ctgacgctca cgccgaccga gtacgaggtg
     8281 ctgcgctatc tgatgcgcaa gtcgccggcc gtgctgacca aggcgcagat cctggaccac
     8341 gtctgggagt acggcttcgg gggccgctcg aacgtcgtgg agctggtcgt cagccgcctg
     8401 cgccgcaaac tcgacgaagc cgacgctgcc gatgccggcg acgtcgccgc cgaagacagc
     8461 gcggccgacg cgggcaggga gccgctgatc cacacggtcc ggggcttcgg atacgtgatc
     8521 cggccggcgg cccggtgacc gggcggctgc ggcggacgta ccgcaggctg cgcctgggca
     8581 cccggctggc gctgggcctt ggcgtgctgt ccctcgtcgt gttcgccgtc gtcggcacgg
     8641 cgctgaccac gtacatgcgc gactatctgg aagcccagct gggcgaccag atgaagctcg
     8701 tccaggtcct gcagtcgaag gacgcccaag tgcacggcgt cgtgcagcgc cagccgtact
     8761 acggctggta caccgcggtg tacgacgtct cgggcgactc ggccgtgctg cgcaggccgg
     8821 ccgacgtacc ggccgacacc cgggcgctca ccgctctcgc cgagacgatg gcgcactcgg
     8881 acacggacct tcggcgcacc gtgcggatcg acggcaaggg cacctaccgg ctacaggcgt
     8941 gcgaggtgga acccggtgtg gtcctcgtca gtgccgcgcc catggcggac gtccaggcga
     9001 ccgtgcggca gctgatcacg gtccaggtgg tcgcgttcgt cctcgcgctg ctggccctgg
     9061 tggtgttcgg ccgggcgatg ctgcggcgcg gtctgaaacc gctgagcgac atggcgcaca
     9121 ccgcccacgg catcgcctcg cacaatctga ccgggtcggc ggcgcggctg ccgctgcgcg
     9181 acgacggccg cagcggcggt ccggaggtcg aggagctgcg caccgcgttc aacaccatgc
     9241 tggagcacat cgacggttcg ctcgccgtcc gcgcggaggc cgaacagcgg ctgcgccgct
     9301 tcgtcgcgga cgcctcgcac gagctgcgta cgcccctgat gtcggtacgg ggttacgcgg
     9361 acctgttcca gtacgcggcc gccaacgcgc ccggggaacg ggacaggcat ctggcgcggc
     9421 tgcgtgccga ggccgccagg atggggctgc tcctggacga cctgctgctg ctcgcccgcc
     9481 tggacgccgc ggaggtggag acaccgctgc ggatggagga cgccgacctg gtggagctgg
     9541 tgcgccaggc ggcggacgcc ttccgcgcgg gccacccgga ccgtccgctg acggtgacga
     9601 ccggtcccga cgccgtaccg ctgcggctcg accccctgcg catccggcag gtgctggaca
     9661 acctgctcac caacgccgcc gtgcacaccc ccgccggaac ggaggtgtcc gtggaggtct
     9721 cggtctcgtc cggcacggcg tgggtggggg tcgccgactc gggcccgggc gttccggcgg
     9781 ccgaccggga gcgggtcttc gaccgcttct accgggtgga caaggcccgc agccgcgacc
     9841 gcgggggcag cggcctgggc ctggcggtcg cccgctccct ggtgcgggcg cacggcggca
     9901 ccgtcgcact gaccggcgaa ccgggggcga cggtcttcac cctcgggatc ccgctgggcc
     9961 gcagggacta gcggggttcg gcacgcaggg gtgggggacc tcaagagccg gcgatgaccg
    10021 gcatgcccgc accacccgca cagccgcgcc ggtccagccg ctcgagccac accaccaggg
    10081 cgagagagct gttcatccgg tcccaggagt acgcgtcgcc caccccgagc tgagcctccc
    10141 tcacagcccg gcacagcgtc tccacgtcga acatctccgc gaccagcgga tgcctcgcgg
    10201 agcggcagag gtcgatgagt tcgtcgccgt gtctgcgcag gccgcgggcg tagagctcgt
    10261 cgaaggggac cttgaccgct cggccgcgga tccgggacgg aagcagatcc gccatggcct
    10321 cgcgcagaac cgccttcgga cggcccggac ggaacgtggc ttccggaggg aggctgcgca
    10381 tcgtggcgat gacctcgtgg tcgagaaagg ggtgcgagag gaagaatccg tcctgccgtg
    10441 cgcggcgcca ggagagcggg tcgggagcgg cgaggtaatt ggccgcctcg aagagcgact
    10501 gttccggcct gcgcccgaac acgaagcggc tctccgcgat gccggcctca cggtagccgt
    10561 gagcccgcgc gaatccgggt cgcagccatc gggggcgggt gaagctgccg aggccgccca
    10621 gcaccgttcc gcggcggacg agcgcggtga tccgttcggc ggtcagcgga agagccggcc
    10681 gcatgacgta gtcgcagacg acgtcccgca cgccacgctc gctgcccgcg gcccaggcac
    10741 gtgcctgctt cgtcagctgc cggagctgcc ctgtgcgggc cagcctgtgc aggtgaaagg
    10801 ggttggcgtc caccatcgca tcggccccgc agccggtcag gaggatgtca cagcccagct
    10861 ccgccgcagc ggcatggagc ctgctccaga acggggcgcg aaaggcgtgc gcatgaggct
    10921 cgtccgcgtc tcccgcgtgg tcctggaagt cgtcgaagtc agccacgtcg ccgacatcga
    10981 ccatcaccgg gcgggccccg ggtgcgtgcc ggtggatctc cttcatcgcc tcgtcgaggt
    11041 acggctgctc ccccgccagc tctcctgtgc cgaagcgccc ggcgagcagg acaaggtccc
    11101 tggggctgtc ctgtcccgcg gccgtcggac gggctgcgag caacgcgacg ctggtggagt
    11161 cggtgccgcc ggagacgtga cacgccgtca tggtgcccat gcggcgcccg acggcgtgct
    11221 ccagtgcgag gcgcagctcc ttcgcggccc cgctgagccg gagcccgtcc gctgtcgagt
    11281 cccacgggtg gtcggcgtga ccgacgcgtc ccagcgcccg accgcgcatc cgcccggtga
    11341 tcgagagctc cacgacctcg ccgccgagga cccggtgcac gccggcgaaa ggggtgagtt
    11401 ccgagtgcgg ttgcgccatg ttcccggtca ggtaccggca gaagtagcga cgttccagct
    11461 cttcgaagtc gcccagccgg cgcgccgagg tgctcaccgc gctcacctgt ccgccggact
    11521 ccctgaagaa cagggggatg cgtgcttgct cgtcccgcat cagcaggacg cggtcgcggc
    11581 acaccaggac agccgcatag tcgccggccg gcagacgcgg tgcggctccc ggtcggccga
    11641 agtcgtccag gaggccgtgc gcgcccgcca cgcggtcacg gaccgagccg gcccagccga
    11701 cgaccaccgc ggtgccggcc cgggaggaga ccgtcgtcac gagtccctgc cgcgccatgg
    11761 cctcggtcgc ccggagcctc ggtgcgcccg cggcccactc gaggcggagc gcttccacgt
    11821 cactgccccg cgcaactgat cgagagcacc ggcgcgaacg cgtgccctcg cggatcggcg
    11881 tcagggatgc acaggcccgc cgaagacgtc caggcgtgca gggcgaacgg gtgctcgcgc
    11941 acaccgacgt ggagcacggc cttcaggccg caccgccgca gcaggacgaa agccgtcacg
    12001 gcctcggtct tgcagtcgtc gttgacgaac caactgctgc ggctgtgtga ccgcaccgct
    12061 cgtttcaacc gctcgacgtc ctccgcggac ggggggtcgg cacgggcgta gaccggggcc
    12121 gccaaggaca ggagccgaag gacgcgcccg aatcccaggg tccggatcag caggtgcact
    12181 ccgcgcaacc agagcccgac ctcgacgtcc gagtgcccct tccggcgggc cgtcgcacac
    12241 ccggcacgga tgagcccggt gacgagttcg gcgcgttcct cagagcttcc gtcggcgaac
    12301 ttccgcatgt ccgtcgcagt catgccgaga aaacgcgtcc gccgcctcca gtccgcgatc
    12361 agagctccgc cggacatcct ggtgacccgg cagtgcggtg acaggatccg cgtcatggcc
    12421 gccagggcat cggtctcctc tgccacccca catcctccaa ggtgggcccg ccgcggtgac
    12481 tccgcggcag gcccggttcg actcggtggg cggtgttcag gactgatatc cgtgcccgtc
    12541 gtagaggccg ccactgaagc cccggatcga acggccactg ccgagaagga cgagcccacg
    12601 cggcatacga cgccgcagtc gtcgaagaaa catcgcctac ctccagaatc aggcggtgtc
    12661 gatcaaatcc aggctactct gccgcgaatg ccccgcaacc ggaccgcaac ccgaccgcga
    12721 ccgcaccgcg gtccggtcgc ggggtgaccg aggtgctgcc gcttcccgct tgtggtacgg
    12781 gtgttgaaac ccaggcggta cgggtgtgga aacccaacga cacgccctcg ccccctcggc
    12841 acccctcagg gctccggtat gtcgtccggg cggagggtga gcagttcctg atgggtgggg
    12901 cggtcgatgt cggacaggcg gcccgccatg tgttcgatca tggtctcgaa gagcgtgcgg
    12961 gcgtcccgcc cgttggacgg gctgccggtg ctcgcccggc cccggaagcg ggccaggagc
    13021 cggggctcca cgtccgggtc gagctcgaag ccgtgccggt ccgccaagtg gcgcacgatg
    13081 cggaccagtt cgcccgggct gtacggcgag aacgtcacga tccgggagaa ccgggacgca
    13141 aggcccgggt tggcctccag gaagccctcc atctccacgg ggtagccggc ggcgatcacc
    13201 acgacgtcct cgcgatggtc ctccatcagc ttggtgagct cgtcgatcgc ctcctggccg
    13261 aggtcgtggt tgacgccgaa gcgccgggcc aggctgtacg cctcgtcgat gaagagcacc
    13321 ccgccgcggg cgctgtcgaa gaccgcgcgg gtcttcaggg cggtggagcc caggtactgg
    13381 ccgacgagat cgctgcggtg cacctccacg agccggccgt ccgacagcac gcccagctcg
    13441 gcgaggatcc ggccgtagag ccgggccacc gtggtcttgc cggtgcccgg cggcccggag
    13501 aagaccagat gacggccgcc gggcggttcg gacaggccgg cgtcgcggcg cagccgggcc
    13561 agccgcagca ggtcgacctg ggtacggacc tggcgtttcg cctcggtcag accgatcagc
    13621 gcgtccagtt cggcctgcgg tccgagcccg gcggcgggct gcccggccgg gggcggcgcg
    13681 tcgcgggtgg tgacggcgtc gaggcgtacg ctgccgtcgc ccgcgacggc ctcgccgcgg
    13741 ctgccggtga tccggctgtc cgtgatccgg ccgctgacgt cgctccgggt gcgcagcccg
    13801 tcgccgtcgc tgccggtgca ggagctgtcc cggatgtcga actggctgct gttctccgcg
    13861 aggatcccgt gcgcaccgga gtccgtcacg gtcagttggt ccgcgaccag gacggcgctg
    13921 tccagaatgt gcgccccgta ccgcgcggcc cgctcgaccg tgcactgacg caccgtcaga
    13981 tatgaggtgt cgcgcgcgaa gaggccgtcg gacacgggct cggagatccg caggttccgc
    14041 gcgacgaccc gggcggatcc ggtcagtacg agagcgcagt cccgcattcc gcacagctcg
    14101 gcgccggtga gttcgccgga tgatccggag ccggacgcgt gcaggccgta cttgcagtcg
    14161 tcggcgcgca gttccgcggc ctcgaaggtg ccgtcctggc acagccgcac cacggaaccg
    14221 gtgagcgcgc gggcctcgac ccgctccagg ctcgcgtggc ccttctccac gacgacaccg
    14281 tgtctggcgt cgacgatgcg gcaaccgttc acccggagcc gggccttctg gtcgacgctc
    14341 agggcggcgt tggacaggtg ctcgaacgag cagtcctcga tcccgcacac ggcttcctcg
    14401 gtcacccgca ccccgacggc ccggcagccg tggaaggagc agtcgcgcag ggtcggatcc
    14461 gcgccgccgg agacgacggc cccggcgtcc gcgccgcgca cgcgggtccc gacgacggtg
    14521 ccgtgcccct ggtcgcggaa gccgagcgcc gtaccggaca ggtcgcgcag cagacagtcg
    14581 cgcacctcgg cctcggcctg ctgctcgacc agcacgccgt gtccgccgaa gccggagaac
    14641 tcgcacgtcc ggagccgggc ccgggtgccc gccccgctga cgtggacggc gctgccgcgg
    14701 ccgtcggcga agacacagtc ggtgacctcg gcgtgcgcgc cctgagacac gaccagcgcg
    14761 tcctcgcccg ccgcctggaa ccgggtgccg cgcagcacgg cgcgggcccc ctgcaacgtc
    14821 gccttgccga cggccagttc accgcccatc acggtgatct cgctgccggc cgaggcggtc
    14881 agggcggccg ctccgtcgcg gccttcgagc cggcagtcgc gcagcagcag ccggccgaag
    14941 accgcgaccg tcgcggtgcc gcggcccacg accgccaggc ccgtgaccac cgcactgccg
    15001 gtcacgtcga gcacgttcgc cccggcgacg gccggttcga cgaccacggt ccccgggccc
    15061 cgcgcggcac agagttcgac ctcacccttg agggacagcg gctcggggta gcggcccggc
    15121 tcgaccatca cccgcagcgg ccccgggccg gtgtgtgcgc gcagcgcggc ggcgatggtg
    15181 cggtggccgc tgtcgccggt gggcgagaca cgcagcacac gcagctcgcc gggggccgcg
    15241 gagcgggtcc cggacggcgg ggcggacggc gggtcggcgg gcggtacggc ggcgtcgaga
    15301 gcgggcgcgg accagcgctg ggcgccgtcg ccgtcccggg ccggcccggc gacccgcacc
    15361 ccgaacgtgt gcagcgcgtg ggcgagttgc ccggggtgga cggccagtcc gagggcctcg
    15421 cccggcacac cggcgagtac cgggacgatc cgcagcgtgc cgtcgggggc ggcccggaag
    15481 cagtcccgcg gcggtgcggc gcccggctcg gggacgagcg ggcgcgcgag cagggcccag
    15541 cggtgctgcc gcccgcgtgc gccctccggg gcggagccga tctccagcga ctccaccgcg
    15601 ctccagggca gggcacggtc cgtgccgccg gcgtgcagcc gcagccctcc cgcgtccagg
    15661 tgcagcgcgc agcgccgggc gaggaggtgg tcgagcgcga ggagcgcggg cagcaccacg
    15721 gcaggggcgg cgagtccggc gccgaggtag gcccagtgca ggcccgggcc cggccgggta
    15781 gcggcgaacc ggaggtagcc gtagcaacag gcgagccaga cggcgaccga cagccgtccg
    15841 ccgtagcccg ccgccctgcg ggtcagcggt gaacgcaggc ggcccgggat gcggtactca
    15901 ctgccggtgg ccaccgcgga ggtggttgcc gggggcagtc cggtacggcg ccagcggggg
    15961 cccgcgtggg tgtcgagcgc gaggtccagc tcgcggggct cgacggccag cgggcgcagg
    16021 tcgacgctca cacagcgcca gcccgcgtcc cagcggggcg tcaactccac tgtccgcagc
    16081 aggagtccgg ccggcccggt gatccggcga cgcgggcccg gagcggtcgc gggcgcggtc
    16141 aggggtgagg gcgtgggcgg ggtcgtaggt gcggtggcag gtgcggtggc aggtggggtc
    16201 gtacgtagga gcagctgctc cgggaaacgg tggccggtgc gcaggatgcg ccggtccacg
    16261 gccgggacca cgcacagcca gtcgagttcc ggccaggacc accgcagccg gcgcagcggc
    16321 ccgtgccact cgatgccgtc gatgtccacc gtgagcgcga ccggccacag agaggtcagc
    16381 aggagccgca cacagacgac ggcgaggacg gctccgccca ggacgcactc ggccaccacc
    16441 ggcacggggg cccgcacggc gtgtacggca tccgcggaca cccagcacac cacggcgccg
    16501 acgcccgcac ccgaggccgc ccacaaccgt ttgcggaccg tccgccggtc ccggtgaaag
    16561 gtggtgcggg ccgcggcggg acgccgcacc ggccggcggg gcgcgggcag gggtgtgccg
    16621 tcggtgggcg cggcgtcgtc gccgctcccg gtgtcatgcc ggacgtccac ccgtaccccc
    16681 cgtgtcgatg tcccggctgt cgagtgcctc gtccccacgg gtgcacttcg accaacccag
    16741 gaccagcgta aaggatggga ctaccatgag tgatgtgtcg tcacacgagg atcacgaccg
    16801 tcaactggcg cttctctgcc agcagttggc gcggctgcgc aggatgcacc gggggccggt
    16861 cggcgcgtcg gggcggctgg tgatcgaccg tgcggtccgg gccgcccgcg agggcgggcc
    16921 gatcggcgaa cacctcgaag ccctgggcct gctgcccggg cgcacggcgg acgaggcgga
    16981 cgagggtgcg ccgcggggca ccaccctccc gccccgggtg acggacggcg ccccgcacgc
    17041 cctgctcggc cagcacgtct gcccgcgcgg ggtctgtacg cggcgggagc agcgggcggt
    17101 cggcgaggag cgtccggtgt gcgagatctt cgacctggcg ctgcgcttcg accccgagag
    17161 gtgaacgggc ctacatgctc tccggattcg tcaccgatgt cggccggaaa ctggcggaac
    17221 gctgggccgc cacgctcgtc ctgcccggcc tgttgttcac gaccgtcgcg gccgtcgccc
    17281 tgaccctgcg ccagagcgcc tggtcggacg tggacctgct gcgcctgcgg gtgacggcgc
    17341 tcaccggagc cggttcgggg gcgggccccg gcgcgggctc gggttcgacg cgtacggcgg
    17401 tgctgctgct cggtgtgctg gccgcgtcct tcgccgccgc gctggtggcc gacgcgctcg
    17461 gcgggccgta cgaacaggcg ttgctcggca gctggccccg cctcctgagc cggcccgccg
    17521 ccgcgctcac cgggcggcgg cgcagaatct ggcaggaacg ggacgacgcc tgccgccggg
    17581 ccgtggcgca ggacacggag ggggccgccg aacgtgccgc ccggctgggc gcgttggagg
    17641 tgctgagaaa ccaagtggcc ctgacccggc cggaatgccc gacctggatc ggggaccggc
    17701 tgcgcgcccc cgccgtgcgc atccggctgg agtaccgcct ggagctgtcc gacgcgtggc
    17761 cccggctgtg gctggtgctc cccgactcca cgcgtcagcc gctggccgag gccaggcagc
    17821 ggctggacga ggcgatgcgc ctcggcggct gggcggtcct gtatctcctg ctgggcgcgg
    17881 tgtggtggcc gagcgccgtg gccggggcgg gggcggcgct ggtggcctgg cggcggggcc
    17941 gggaccgggc cgaggagtac gccgagctcg tcgagtcggc ggtcgatgtc catctccagg
    18001 agctgttcga acggttcgac gaggaggccc gcccggtccg ggcgagcctg ggccccgccg
    18061 tcaccgaacg gttccgcaag ggcgcggggc cacgacgccc gtgacacgcg ggaccacgac
    18121 gcccgtgaca gccgaacgcg ggagcggagg acccctgccg cccggacacg ggagcgacgc
    18181 acaggacacc cgggcaccgg accacggcgc ccacaccacg ggaccggacg cgagaacggg
    18241 gtgcacgaga tgaccgagcc acagcagttg cccggggagg accggccggc ggagcgggaa
    18301 cggctgctac gggcggtacg ggggcgcctg gacgcgctgg gcggaccgac gggcaacggc
    18361 catctgcaca ccgcggaggc acgccaggag accgaccgtc tgctgcgcca cctcgtggct
    18421 ccccacccgg ccacgggcgg cggccacgca ctcgacgccg aagtggcgta cgtactcgga
    18481 gtgatgtatc tgttcgtcgc ggacgaccgg cccgacgccc ccaccgccgc acaggacggc
    18541 cagtgcgccc tcctgctgct cgcccccttc tactgccacc tgccggacca gccggatgtc
    18601 ctgccccctc ccctgcgcgc cggactcgac cagctcctcg gcgccgaggg ccgacggccc
    18661 gacgcccccg aggagatcgt ccaggagcac gccgcgtccc tcgccaacct ggcgatgctg
    18721 ctgctggaac tgggcatcac cctggcgtac ccggaagcca tccgcgttgc ggccgacctg
    18781 gcccgcgagg cccttcccca tctgtcgccc gacggccacg accgcgccct ggccggatgc
    18841 aacctcggct atgccctgct cctgagcggc ccgacccccg tctcctcccc cggccaggcc
    18901 gaccccgagc agctggcgga ggccgtctcc gtgctgcgca ccgcgttcgc cgccaccccg
    18961 cgcgagcacc cgaaccacgc ccggtgcgcc aacggcctcg gcctcgcgct gctcgcctcg
    19021 gccggtcagg ccgaggaccg cacccaactg gccgaggccg ccgcgatgtt gcgcatcgcc
    19081 acccagaccg ccacggaggt cgaccagaac ctcccgcaga tgtactccga cctcggttac
    19141 accctcaccc tctgcgcccg caccgccggg gagggcgagg agccgggccc ggaggtccgc
    19201 gaggaggccg tcgacgcgct ccggcgtgcc gtggacctca ccacgcccgc cgaggacggg
    19261 gagatgctgc gcacccgcct cgaccggctc gccgacgccg tggtgatcgg ctccccctcg
    19321 gacgaccggc cgcgcgccgc cgcacaggcc gagcaggccg tcgacaccct gcggcgcctg
    19381 ctcgacctca cccccgaagg gcacccggag cggggggacg tactgctgcg gctggcgggg
    19441 aaccggttgg tggcacagca tccgcaggag accatcgacc tgctggtaca gggcgagtcc
    19501 gcgtacgcca cagacccccg ccgggagcag atcgcccggg cgttgctcgt ggaggcggcc
    19561 atgctcaagg gagagctgga ctcccgcgcg gacctcaccc ccgagcagca ggcggactgg
    19621 caggccatcg acgacgtcat gctcccgctg ctgtccgggg acacgaccgg ccacccgatg
    19681 cggtccgtga tgaatctgat cggcctcggc ggggaggggg gcgggagccg cagccaggaa
    19741 ctgatggact tcggcagcat ggtcctcggc tacccggacc gggtcggcct gaacgagatc
    19801 ttcgccaagg cgatggagct ccaggcccgg cgcatcgcca ggctgcccga ggaggaacgc
    19861 gcgggcgccg tcgccgcgtt cctggcggga gacgacgacg agggcgcgcc cgggccgccg
    19921 ggcgggcggg tcgaggagtc cgaggagccg ccggacacca gcagcctcga cgagctgctg
    19981 gagatccacg aacgactgct gccgcggctg ccacccgact cccgcgagca ccgcctgctg
    20041 cacggcgggc ggaacatgct gcgcctcgtg cagatcatgt acgagtccat gtacgcgccg
    20101 ggcgacaccc ggacgcgtct gcagctgatg cgccgggccc tgccgctgat gcgggagctg
    20161 ttcgaggaac tgcccgccca gttggaggag ctggggatca agccggagct cttcggcgcc
    20221 catacggcac tggcgttcgc gtacgagtcg ccgttcgagc agctggaggc ggtcgaggag
    20281 ggggtgcggg ccgcccgccg gaggctcacg gaactcgccc cggacacgcc ggagtacgcc
    20341 gagacccgga ccaccctggc cctgtccctc ttcgtccgcc atgccctgtg gtccgaggag
    20401 gccgactacg aggaggccgt gggcatcgcc cgggagctga cctcggcgcc ggctcccggc
    20461 tggcgcacgg ccatgctgct gacgcagtgg acctccgcgg cccagtcgcg gatccagcgc
    20521 accgggctgc tgggccaggc accgcccggg gtcgggcagt cgcccagcct gatcacccgg
    20581 ctggcctccg acggcgccgc caccgcgctc gacgaccggg accccgtgga agcgctggag
    20641 accctggagg acggccgggc gcatctgctg tcgggggcgc tcaacgcccg ccgcgaactg
    20701 gaggtcctgc acggtgcgga cgccaagctg cacggccggc tgcgggccgc gctggaacgg
    20761 atccgggcgc tccgcacggc gagggaaccg ggccgatggc ccacaccgga cgaggaggac
    20821 gagctgcggt ccgcttccga cgacgcggcc tggctcgtcg ccgaactcca gcagcacccg
    20881 ggcttccagc gctttctgac cccgcttccc ctgggtctcg acgacctgct gcccgccgcc
    20941 gcggaggggc cggtggtgag cgtcaacatc aacccgcgcc gctgtgacgc cctggcgctg
    21001 tgccccgacg ggctgcgcgc ggtaccgctg ccgcggctgt acgcctccga tctggtggca
    21061 caggccgagt ccttccgggt cgccgtcgag gcactgacgg ccggaccgcg cgaccctctg
    21121 ttcgaggacg cccgggagat cttcacggga acgctggcct ggctgtggga cgtactggcc
    21181 gaaccggtcc tggacgccct cgggttcacc ggtccgccgg agtcaggagc gccctggccc
    21241 cggctgtggt ggtcgccgtc cggggtgctc aactcctttc cgctgcatgc cgccgggcgc
    21301 cacggcagcg gggaggcggc ggacgccgcc gtcctggacc gggtggcctc ctcgtacaca
    21361 ccgaccctgc gcgccctgct cttcagccgg gcccgcaggc gcgcggcacc cggccggcgg
    21421 cgcaccctgg ccgtggccat gccgcagacc gccggacagg ccccgctggc ccgtacggtc
    21481 acggaggcca ccgaggcggt ggcggcgggc ggaggcgttc cgctgatcgg accggccgcc
    21541 acccgggact cggtgcgtgc ggccatggtg gacgcggccg tggtgcactt cgcgtgccac
    21601 gcggacagtg accccgagga cctgtcggcc ggccggctgc tgctggccga cggcgacctg
    21661 ctgatccgcg acatcgccga gctccacctg gagacggccg agttggccta cctctcggcc
    21721 tgcggcacgg cccgcggcgg cgccaccgcg gcgctcgccg acgaggtgat ccacctgggc
    21781 tccgcgttcc agctcgccgg ctacgcccag tcggtggcca cgctctggga ggtgggcgac
    21841 tccttcgcgg ccagggccgc ggccgagttc caccgcaccc tggccccctc cctcccgggc
    21901 cccggccccc tgcccgcggc cctggccctg caccacacgg tgcgctcgct gagacaagac
    21961 gaccgggagc ggccttggac gtggtcggcg ttggtgcacg cgggggcctg agcggcgcgt
    22021 gtgcggcggg cggaagacgg gccggagacg ggcaccgggc gggcgccaga cgagcggacg
    22081 agcggacgag cggacgagcg ccagacgggt aaaaaatccc gatttaggag ggttcatttc
    22141 ctgttgaccg cactagaatg agaaacagcc tgcgggacga gcgagggagt tcgaccggag
    22201 tagccgactt tggcgtgaag ctgggagtac gtggtttccg cccgggccga cgtcgacggt
    22261 cgggctgaga ggctggaagg tcgcaggacc tgacagcgac ctctggaacc tgatccggac
    22321 cataccggcg cagggagccc gtctcgcagg ttattcgtgt gcgaagcgac gcacccacgg
    22381 accccgcggt attgtcctga catggatgcc gtacgtgcgg tcctgatcga catcgacggt
    22441 gtgctc
//
