LOCUS       NC_003155              22178 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2625582
            Orig. end                         :: 2647760
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22178
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22178
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22178
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12178](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12178)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            604..1854
                     /db_xref="GeneID:41539251"
                     /locus_tag="SAVERM_RS11315"
                     /old_locus_tag="SAV_2155"
                     /old_locus_tag="SAVERM_2155"
     CDS             604..1854
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675708.1"
                     /locus_tag="SAVERM_RS11315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2155"
                     /old_locus_tag="SAVERM_2155"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_010983595.1"
                     /transl_table=11
                     /translation="MSLLPEQRYPSVTEIVSSARALAAHRPGLCALRQVGVSRAGRPLH
                     LLSVGHATRAVLVVAGAHANEPTGGSTLLSLAERVLYERELRDGTSWHFLLCADPDGAA
                     LHVTPAPRTLFDYHLGFFRPAGPEQPEWSPSVLPPDRLPPETRALTRVIDELRPYLQVT
                     LHGTDLGGSWVQLTKDIPGLAEPFAKSAAELHIPVETGASDAAGWPASGPGVHVMPAPG
                     SNAAYPSMPDDARHSTWYHTHRYGGLTAVVEVPMWASDLVDDPAPHPAPAAALRQLGRR
                     LLRDALEVELVLTEALPRLPGPDGPLLRAAKWALELVPGLAGDWAQAPPADTTMAYVGS
                     VDAFGRRLPLRAAAMLLRVLQEADDRAAPRLEQLVAAWSDAFAVRFRARWVPLEDQVEH
                     QSRTVVAAARHARDRAA"
     gene            complement(1894..2334)
                     /db_xref="GeneID:41539252"
                     /locus_tag="SAVERM_RS11320"
                     /old_locus_tag="SAV_2156"
                     /old_locus_tag="SAVERM_2156"
     CDS             complement(1894..2334)
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983596.1"
                     /locus_tag="SAVERM_RS11320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2156"
                     /old_locus_tag="SAVERM_2156"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_010983596.1"
                     /transl_table=11
                     /translation="MTKTTMAVPGALLAAIALLSAAPAQAAAHRVTPGNWLYVTVTTGD
                     ARSSHISRLLTCDPPHGHAHAARACEELAAADGDITRIPPKRTFCPMIYAPVTADAHGE
                     WNGRHVEYRHAFGNACGLEGETGAVFALSEQASDGPTPGLRS"
     gene            complement(2331..3683)
                     /db_xref="GeneID:41539253"
                     /locus_tag="SAVERM_RS11325"
                     /old_locus_tag="SAV_2157"
                     /old_locus_tag="SAVERM_2157"
     CDS             complement(2331..3683)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381315.1"
                     /locus_tag="SAVERM_RS11325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2157"
                     /old_locus_tag="SAVERM_2157"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_037650076.1"
                     /transl_table=11
                     /translation="MPPLLRYPTVDELAARAAALVARRPGDARLRRVGTSRGGTPLWLL
                     SVGHGTRHALVVAGPHANEPVGGATALRLAERVLAGPGPAEGADATWNLLLCLDPDGAR
                     RNEGWLSGPYTLGHYFRHFFRPGFLEQPEWLPDGAERAALPETRALLDLQDELRPFFQC
                     SLHGVDVGGGFVELTQDLPGLAQRVAGTAARFGIPRELGPYDTLYWPPLGPAVYRIPPP
                     RRGDLAAAITEAAVESTWFHPQRYGTVTAVVEAPMWGVAAVEDGSPPGDADAVLRAVSR
                     TLRRDTGLLEDILARIRPRLAATPDTASLLAPVDDYLLVGPGLADSWDPDTFDGTGRPL
                     PPLNTARLTALGISGRRVALRTAGLLRQLATAAGAAASDVLPELDRLIDEWCADYRDGY
                     GARWVPVGHQVEYQTRVVLAAFELAGRYAPVRSHSGEPRWGSDAVVPMHTE"
     misc_feature    complement(2730..2732)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3903..4454)
                     /db_xref="GeneID:41539254"
                     /locus_tag="SAVERM_RS11330"
                     /old_locus_tag="SAV_2158"
                     /old_locus_tag="SAVERM_2158"
     CDS             complement(3903..4454)
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481978.1"
                     /locus_tag="SAVERM_RS11330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2158"
                     /old_locus_tag="SAVERM_2158"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_042492943.1"
                     /transl_table=11
                     /translation="MTSSFEFHTYPARLSDAERDRALKVLRDGVALGRLSHDTFIRRME
                     LALVARQPAELAALTADLPAEKRVSRLVFGTVEAVSGFTVRLRRAWQAERLPKLLLPHP
                     GSTHPLRIGRDPASGLRLSHDTVSRVHAELSRQGGLWVLRDLGSTNGTTVNGRHVIGAA
                     VVRDGDQVSFGNMAFRLATE"
     misc_feature    complement(4563..4576)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            4627..6372
                     /db_xref="GeneID:41539255"
                     /gene="treZ"
                     /locus_tag="SAVERM_RS11335"
                     /old_locus_tag="SAV_2159"
                     /old_locus_tag="SAVERM_2159"
     CDS             4627..6372
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539255"
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133692.1"
                     /locus_tag="SAVERM_RS11335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2159"
                     /old_locus_tag="SAVERM_2159"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_010983599.1"
                     /sec_met_domain="Alpha-amylase (E-value: 5.2e-11, bitscore:
                     41.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQAARVTLHCGGATRALARDEERDGWWKGDAEAGDGTR
                     YGFALDDGAVLPDPRSRRQPDGPDGLSAVVDHGRYAWRADRPGRGLPGAVLYELHVGTY
                     TREGTLDAAAERLGHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHELGLGVVLDVVHNHLGPSGNCLPAFGPYFTDTHHTPWGAAVNLDAPGSDEVR
                     AYLVGSALAWLRDYRVDGLRLDAVHALCDTRACHFLEELSTAVDALAADQDRPLFLVAE
                     SDLNDPRLVTPRHEGGLGLHAQWNDDFHHALHTALTGESQGYYEDFARAPFAALAKTLT
                     GGFFHDGTYSTFRGRCHGRPLDRTRVSAHRLLGYAQTHDQVGNRAQGDRLSASLSPGLL
                     ACAATLTLTSAFTPMLFMGEEWAAGTPWQFFTDHTDPELAEAVRRGRRREFAAHGWAEE
                     DVPDPQDPATRDRSCLDWAEPESGIHARVLAWYRGLITLRHHEADLSDPDLTDVKVAYD
                     EEARWIAFRRGDVRVAVNLSKEPARIPLGLAHARVLAAWEPVETPGADGVLELPGESSV
                     VLTQA"
     gene            complement(6482..7417)
                     /db_xref="GeneID:41539256"
                     /locus_tag="SAVERM_RS11340"
                     /old_locus_tag="SAV_2160"
                     /old_locus_tag="SAVERM_2160"
     CDS             complement(6482..7417)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539256"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071453.1"
                     /locus_tag="SAVERM_RS11340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2160"
                     /old_locus_tag="SAVERM_2160"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_010983600.1"
                     /sec_met_domain="APH (E-value: 5.4e-22, bitscore: 77.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADSIRRLVRSVLADGPADGAGPEVRPVAAGGEHSTWW
                     VGTRHVLRLAPDRDASVRLRRELRLRDLVRPHIGVAVPASVAHGEWATGLAYTLDTRLP
                     GAGGEEHAVSAVGEADLAALLTGLREVPVRQAEPLGVPRAVPRSLEALRTVAEDAAQYL
                     SGADEFDADRLGQLTAPAAVQLAAQPGAAVLVHHALKGEHLVVSGDGRVRGVLDWTDAV
                     IGDPAEDIAGLAIAVGAPAAVRAATLAGYGARPCLRGLWLTRCDTLVRLADRLQGRDDS
                     PLPLLRTRLRRAWEAILLERVTELPGDETL"
     gene            complement(7461..8606)
                     /db_xref="GeneID:41539257"
                     /locus_tag="SAVERM_RS11345"
                     /old_locus_tag="SAV_2161"
                     /old_locus_tag="SAVERM_2161"
     CDS             complement(7461..8606)
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539257"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009308309.1"
                     /locus_tag="SAVERM_RS11345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2161"
                     /old_locus_tag="SAVERM_2161"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_010983601.1"
                     /transl_table=11
                     /translation="MTGTPAPPGTGDPAPFTAADYAARMRRAAQSAADAGLDGVLVAPG
                     PDLVWLTGYRPVETERLTLLVLRAGHDPVLVVPTLEAPDAAEAAGAPALTLRDWTDGKD
                     PYEAAATLLDRSGRFGISDNAWAMHLLGLSGRLPGTRYVALTEALPMLRAVKDAAELER
                     LAAAGAAADATFEEIRKVPFAGRRETDVAADLAELLRQFGHSQVDFTVVGSGPNGANPH
                     HEAGDRVIERGDMVVLDFGGLKHGYGSDTSRTVHVGEPDEEERKVHDLVRAAQEAGFRA
                     VRPGVACQDVDRAARAVIADAGYGDRFIHRTGHGIGVTTHEPPYMIEGEQRALVPGMCF
                     SVEPGVYLPGRFGVRIEDIVTVTDDGGRRLNNTSRELVIVD"
     misc_feature    8716..8734
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.93"
                     /tool="antismash"
     misc_feature    8729..8743
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.91"
                     /tool="antismash"
     misc_feature    complement(8877..8891)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.9"
                     /tool="antismash"
     gene            complement(9125..9772)
                     /db_xref="GeneID:41539258"
                     /locus_tag="SAVERM_RS11350"
                     /pseudo=""
     CDS             complement(9125..9772)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657043.1"
                     /locus_tag="SAVERM_RS11350"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="PDZ domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQESGGDRASGTPRRPHAAPPRRGKRLTTLLFA
                     VFVGTVLVLSGIGLGTVGATVIG"
     gene            complement(10001..12178)
                     /db_xref="GeneID:41539259"
                     /gene="cyc2"
                     /locus_tag="SAVERM_RS11355"
                     /old_locus_tag="SAV_2163"
                     /old_locus_tag="SAVERM_2163"
     CDS             complement(10001..12178)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /db_xref="GeneID:41539259"
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125297.1"
                     /locus_tag="SAVERM_RS11355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2163"
                     /old_locus_tag="SAVERM_2163"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_010983603.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-81, bitscore: 272.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFQLPHFYMPYPARLNPHLDEARAHSTRWARGMGMLEGSGIW
                     EQSDLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLETFKRTQDREGGKAY
                     LDRLPLFMPLDLSAPVPEPENPVEAGLADLWARTVPAMSADWRKRFAVSTEHLLNESLW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPAAVAGSRPLRVLMETFSD
                     GVHLRNDLFSYQREVEEEGELSNGVLVLETFFGCTTQEAAETVNDILTSRLHQFEHTAL
                     TEVPALALEKGLTPPEVAAVAAYARGLQDWQSGGHEWHLRSSRYMNEGALSQKRPFGLS
                     AIGTSAADLRGLLADAGAERLRRYTHVPFQKVGPSRIPDFHMPFQVELSPHLEGARARL
                     TPWMHSTGMLQEGVWDEDKLTAYDLPLCSAGLDPDATPDELDLSSRWLAWGTYGDDYYP
                     MVFGPRRDLAAAKLCTRRLSACMPVDGEEVPAPVNGMERGLIDLWAITTAEMTPDERRT
                     FRASVDVMTESWVWELSNQLQHRIPDPIDYLEMRRATFGADLTLSLCRVGHGPKVPPEI
                     YRSGPVRSLENAAVDYGMLINDVFSYQKEIEYEGEVHNAILVVQNFFGCDYPTALGVIN
                     DLMTQRMHQFEHVAAHELPLLYKDFKLPQEVRDIMDGYVVELQNWMSGILKWHQDCHRY
                     GAADLARRAHGFVPDRAPSAPFTAWAAPVAR"
     gene            12380..13159
                     /db_xref="GeneID:41539260"
                     /locus_tag="SAVERM_RS11360"
                     /old_locus_tag="SAV_2164"
                     /old_locus_tag="SAVERM_2164"
     CDS             12380..13159
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-241). E-value:
                     5.6e-25. Score: 80.3. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS11360_Abhydrolase_1.1"
                     /codon_start=1
                     /db_xref="GeneID:41539260"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675699.1"
                     /locus_tag="SAVERM_RS11360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2164"
                     /old_locus_tag="SAVERM_2164"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_010983604.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.2e-17, bitscore:
                     61.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 7e-19, bitscore: 67.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSFVLPHELHGDGAHKVFAVHGWFADRAAYAAVLPDLDRAAFTY
                     ALVDLRGYGRAKDAVGAFTTAEAAADLVELADRLGWDRFSVIGHSMGGTVAQRLLALAP
                     KRLRRIAGVSPVPASGLSLPADQWQLFADAAHKPENRRAIIDVTTGGRRPGAWLDRMVA
                     RSLADSDAKAFRAWLDSWAGEDFQAEVTGAGVPALAVTGALDPALSSALLRDTWMRWYP
                     RGELRELPSAGHYAMDEAPLDLIHVVEEFLRAEDAGE"
     aSDomain        12440..13102
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS11360_Abhydrolase_1.1"
                     /evalue="5.60E-25"
                     /label="SAVERM_RS11360_Abhydrolase_1.1"
                     /locus_tag="SAVERM_RS11360"
                     /protein_end="241"
                     /protein_start="20"
                     /score="80.3"
                     /tool="antismash"
                     /translation="VHGWFADRAAYAAVLPDLDRAAFTYALVDLRGYGRAKDAVGAFTT
                     AEAAADLVELADRLGWDRFSVIGHSMGGTVAQRLLALAPKRLRRIAGVSPVPASGLSLP
                     ADQWQLFADAAHKPENRRAIIDVTTGGRRPGAWLDRMVARSLADSDAKAFRAWLDSWAG
                     EDFQAEVTGAGVPALAVTGALDPALSSALLRDTWMRWYPRGELRELPSAGHYAMDEAP"
     CDS_motif       12635..12670
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAVERM_RS11360_0001"
                     /evalue="3.30E-04"
                     /label="NRPS-te1"
                     /locus_tag="SAVERM_RS11360"
                     /protein_end="97"
                     /protein_start="85"
                     /score="13.3"
                     /tool="antismash"
                     /translation="VIGHSMGGTVAQ"
     gene            13156..14421
                     /db_xref="GeneID:41539261"
                     /locus_tag="SAVERM_RS11365"
                     /old_locus_tag="SAV_2165"
                     /old_locus_tag="SAVERM_2165"
     CDS             13156..14421
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539261"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431984.1"
                     /locus_tag="SAVERM_RS11365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2165"
                     /old_locus_tag="SAVERM_2165"
                     /product="cytochrome P450"
                     /protein_id="WP_010983605.1"
                     /sec_met_domain="p450 (E-value: 1.5e-19, bitscore: 68.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVREQAPPVPDVFDPRRYAAGVPHAAYRTLRDHHPVARQAEPEV
                     LGWPAGPGFWAVTRHADVVRVLKDSTTYSSRFGATQIRDPDPDDLPFIRDMMLNQDPPD
                     HGRLRRLVSRAFTPRRVDRFESLARDRARTLLAAALAGARAGDGSCDLVATVTDDYALL
                     NLADLLGVPESDRGLLLHWTRRVIGYQDPDEAGEPLLDAAGKPVDPRSPGALRDMFEYA
                     RQLASYKREHPADDIMTTLATDPELTGPELAMFFFLLTVAGNDTVRGAAPGGLLALAEH
                     PEAYARLRARPQQLPSAVEELLRWHPPVLTFRRTAVRDTDLAGQRIRAGDKVVVFHASA
                     NRDGRVFTAPDRLDLSRSPNPHVSFGDGPHVCLGAHFARLQLRVLYAQTLRALPAPRVA
                     GPPGRLVSNFINGIKSLPLQVA"
     gene            complement(14430..15644)
                     /db_xref="GeneID:41539262"
                     /locus_tag="SAVERM_RS11370"
                     /old_locus_tag="SAV_2166"
                     /old_locus_tag="SAVERM_2166"
     CDS             complement(14430..15644)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142846.1"
                     /locus_tag="SAVERM_RS11370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2166"
                     /old_locus_tag="SAVERM_2166"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_010983606.1"
                     /transl_table=11
                     /translation="MSEAPVIVSDDPGSFPHSVLAERHPALIRKVRDAFPYGPEQRRAL
                     DALQKSALDGVIEPLGTPAEDHERWVAWGLPKHLGRSWFSVPFLWAESYFYRQLLAAVG
                     YFGSGPWQGIDPFRPFKLAELDTPEAAEELAALDALTGRPLDEQARALLHGSLWGNRAD
                     LGFRISAGGDGSVDSQLLVDDSESLWALLPAHTADSDSDSDSDADGTAGPARTVCLVAD
                     NAGRELIPDLLLIDHLLHHGRAERAVLHVKPYPYFVSDATTADVLDAVRRLTGTKGAAG
                     AAGDRLWSALTDGRLVVRAHVFSCAPLPYADMPDDLRREFAEADLTIMKGDLNYRRLVG
                     DRLWPPTTPFTTPTAYFPGPVVALRTLKSDVIVGLDADTEAALAAAQGQGWRTSGTHAV
                     IQARP"
     gene            complement(15637..16212)
                     /db_xref="GeneID:41539263"
                     /locus_tag="SAVERM_RS11375"
                     /old_locus_tag="SAV_2167"
                     /old_locus_tag="SAVERM_2167"
     CDS             complement(15637..16212)
                     /codon_start=1
                     /db_xref="GeneID:41539263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481969.1"
                     /locus_tag="SAVERM_RS11375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2167"
                     /old_locus_tag="SAVERM_2167"
                     /product="hypothetical protein"
                     /protein_id="WP_167544192.1"
                     /transl_table=11
                     /translation="MPTESAHGPVGVICPSCGESTVRAVEEICADEASVRDGLSNRLAK
                     APGVTSGFDGCLHFVEGMLMVGVGAALAYSGVDNDKPLYTIGGALLAVLLFVGTILVVR
                     GEARERDVVNAGEHRADRLWRPAHYCSGCASVFCPGGGPWEGLLTPEQFQKYVWTEAGY
                     GKQLDPAVRDLELPVGIRTGPEGAQDHV"
     gene            16386..17321
                     /db_xref="GeneID:41539264"
                     /locus_tag="SAVERM_RS11380"
                     /old_locus_tag="SAV_2168"
                     /old_locus_tag="SAVERM_2168"
     CDS             16386..17321
                     /codon_start=1
                     /db_xref="GeneID:41539264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657056.1"
                     /locus_tag="SAVERM_RS11380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2168"
                     /old_locus_tag="SAVERM_2168"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_010983608.1"
                     /transl_table=11
                     /translation="MTAHRTAAAAAVAVAAPLLLTAWAAGPAQAHGAPTDPVSRVVACS
                     PEGGGRARTAACTAAIAANGSPFTAWDNLRVAGVNGRDRQLIPDGKLCSGGLPAYKGLD
                     LTRSDWPSTRLTPGASLTMKYSSTIPHTGTFKLYLTKQGYDPTKPLTWSDLPAQPFAQL
                     KDPALAGGAYRLGAKLPADRTGRHVLFTIWQNTSTTDTYYSCSDVVFAKAKAAAGAGGG
                     STGAARKPAGKATPSSPAATSSPSSSPSPSRSETAASTPPPSRTAVPGTPAAATAHRSD
                     SGPSLPLLAGGAAAVVLAAGAVVSLRRRRR"
     gene            complement(17452..18108)
                     /db_xref="GeneID:41539265"
                     /locus_tag="SAVERM_RS11385"
     CDS             complement(17452..18108)
                     /codon_start=1
                     /db_xref="GeneID:41539265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999857.1"
                     /locus_tag="SAVERM_RS11385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_037650027.1"
                     /transl_table=11
                     /translation="MRTRPLLALAGVVVALSVSAMSPASAAGTVLTTGSAGGDAVATGD
                     VLSASLATGTAATLYSSATGTSGVSCSASTFTAGVVDNPAASGTATESVTAHTFDGCTS
                     NVIGVLGVSGVTVNNLPYTTTVGSDGTVTVTPASGSTIQTTVKLSTLLGTINCVYQAPS
                     LSGTASNTDNSITFTNQQFTKTSGSSLCFSSGYFTAKYAPVKDTSVSGSPSVFVN"
     misc_feature    complement(18671..18686)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    18684..18699
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            18888..19562
                     /db_xref="GeneID:41539266"
                     /locus_tag="SAVERM_RS11390"
                     /old_locus_tag="SAV_2170"
                     /old_locus_tag="SAVERM_2170"
     CDS             18888..19562
                     /codon_start=1
                     /db_xref="GeneID:41539266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996942.1"
                     /locus_tag="SAVERM_RS11390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2170"
                     /old_locus_tag="SAVERM_2170"
                     /product="DUF6230 family protein"
                     /protein_id="WP_010983610.1"
                     /transl_table=11
                     /translation="MASSSDATASHGSTPQTPESGSAAEGSERRGRVRLRRAAVMAVPA
                     TAIAAGLVILTAQGALGVQFAISGMPFTVTATDLNGTGFEQFGNLDNMAEGSPNAGDTG
                     GQVLVVTSAIKDATLTKLCQSVDLGGTNLRIEAGAGKDKVVASDLTTDSTELSGDAEFN
                     KIEIGNDASTLDKAGVQGNKGVFSQQADTVHIANLRQTNYATTAGVFKLPGLHLSFSDK
                     AC"
     gene            19562..19981
                     /db_xref="GeneID:41539267"
                     /locus_tag="SAVERM_RS11395"
                     /old_locus_tag="SAV_2171"
                     /old_locus_tag="SAVERM_2171"
     CDS             19562..19981
                     /codon_start=1
                     /db_xref="GeneID:41539267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675691.1"
                     /locus_tag="SAVERM_RS11395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2171"
                     /old_locus_tag="SAVERM_2171"
                     /product="DUF6114 domain-containing protein"
                     /protein_id="WP_010983611.1"
                     /transl_table=11
                     /translation="MASRPRSAFRRWRASRPFWGGLLLTLGGAEVLLTEKVSLKVVMHI
                     GMQGLAGYLLPVVMMLCGLLILFNPAQRLFYSVIGILVTLGTWLTSNLGGFFIGLLLGA
                     TGSCLAFGWLPDQEPRRRLLRRHRTPSPTADSPAS"
     gene            complement(20289..21089)
                     /db_xref="GeneID:41539268"
                     /locus_tag="SAVERM_RS11400"
                     /old_locus_tag="SAV_2172"
                     /old_locus_tag="SAVERM_2172"
     CDS             complement(20289..21089)
                     /codon_start=1
                     /db_xref="GeneID:41539268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138198.1"
                     /locus_tag="SAVERM_RS11400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2172"
                     /old_locus_tag="SAVERM_2172"
                     /product="VOC family protein"
                     /protein_id="WP_010983612.1"
                     /transl_table=11
                     /translation="MKRNGTLAREIVSSHSVFGAPCWVSLTTRDLEAAENFYKAVLGWR
                     WRTGKLGDRFRFALSEGMPVAGIAAVASQWQMAAAWTPYFAVPSADEAVSRSQERGGTT
                     AVGPIAFPPGRAALLADRDGAVFGIWEGQLVAGWDHWRRAAPAFVRLHTRDAFDAAIFY
                     GEVLEWASARPGACQVQYDGKEVVLLSQGDVVARIHSGAVGAAPDPQLRPHWQVHFAVD
                     DVEACVHAAQDHGGTVLRWEPGATEAVLSDPDGARFTVTARTKR"
     gene            complement(21261..21749)
                     /db_xref="GeneID:41539269"
                     /locus_tag="SAVERM_RS11405"
                     /old_locus_tag="SAV_2173"
                     /old_locus_tag="SAVERM_2173"
     CDS             complement(21261..21749)
                     /codon_start=1
                     /db_xref="GeneID:41539269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142840.1"
                     /locus_tag="SAVERM_RS11405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2173"
                     /old_locus_tag="SAVERM_2173"
                     /product="hypothetical protein"
                     /protein_id="WP_010983613.1"
                     /transl_table=11
                     /translation="MDRQHTPDPRPRLSDAHRRLSDPRPGLSAPLLCERPQRLSLPVEL
                     PAGLGYDAVGTSPEHGERIMECLPRVGCVFADDLRWWWIVPSGSHVGVTWPSCTTYAIG
                     AYLADPSWTRASGRPRPGGPRLIHRPDGDSPYTPPIPLYFLICRLAGISPSWSLGAVS"
ORIGIN
        1 ggactggccc acgcgtcgtt cgccgagggc ctgtcggtgg ccgagacgct ggccgggctg
       61 ccgtccgcgc ccgtggacta cgcggccgtg ccccgggtca cgtactcgtc gccgcagacc
      121 gcctccgtgg ggctgggcga ggcggaggca cgcgcgcgtg gacacgaggt ggacgtcaac
      181 acgatgccgc tgaccgccgt cgccaagggc atggtccacg gccggggcgg gatggtgaag
      241 gtcgtcgccg aggagggcgg cgggcaggtg ctcggcgtgc atctggtggg cccccacgtg
      301 tccgagatga tcgccgagag ccagctgatc gtcggctggg acgcacagcc ctccgacgtg
      361 gcccggcaca tccacgcgca ccccacgctg tccgaggcgg tcggcgaaac gtttctcacg
      421 ctcgcgggac gggggctgca tcagcagtga ggcccgccgc ggagggagcc ggaccgcccc
      481 tgcgaggacg gggcacgccg tcaacgcctc ttggcgcccc ctggcgccgc cccgtcttct
      541 ccttgacagt tccccccggc cgtggactac tgcggattgc gacgtcgggc ggaccaaacg
      601 ggggtgagtc tcctgccgga gcagcgctac cccagtgtga ccgaaatcgt ttcgtccgcc
      661 cgcgcgctgg cggctcaccg gcccggcctg tgcgcgctca gacaagtcgg tgtctcccgc
      721 gcgggccgac ctctgcacct gctgtccgtc ggccacgcga cccgtgccgt cctggtcgtc
      781 gcgggcgccc acgccaacga gccgaccggc ggttcgaccc tgctgtcact cgccgaacgg
      841 gtgctgtacg agcgggagtt gcgggacggc acctcctggc acttcctgct ctgcgcggac
      901 ccggacggcg cggccctgca tgtgactccg gcgccgcgca cactgttcga ctaccacctc
      961 gggttcttcc gtccggcggg ccccgagcag ccggagtggt cgccgtccgt gctgccgccg
     1021 gaccggctgc cgcccgagac acgcgcgctg acccgggtca tcgacgaact gcgcccctac
     1081 cttcaggtga cgctccacgg caccgatctg ggcggcagct gggtgcagtt gacgaaggac
     1141 atccccggcc tcgccgagcc gttcgcgaag tccgcggcgg agctgcacat tccggtggag
     1201 acgggcgcct ccgacgcggc gggctggccc gcgtccggtc ccggcgtcca tgtgatgccc
     1261 gcgccgggtt cgaacgcggc gtacccgagc atgcccgacg acgcccggca cagcacctgg
     1321 taccacaccc atcggtacgg cggtctcacc gcggtcgtcg aggtcccgat gtgggcgagc
     1381 gacctggtgg acgatccggc gccgcacccg gcgcccgcgg cggccctgcg gcagctgggg
     1441 cggcggctgc tgcgggacgc gctggaggtg gaactggtcc tcacggaggc gctgccgcgg
     1501 ctgcccggcc ccgacgggcc gctgctgcgc gccgccaagt gggcgctgga gctggtcccg
     1561 gggctcgcgg gcgactgggc gcaggcgccg cccgcggaca ccacgatggc gtacgtcggc
     1621 agtgtcgacg cgttcggccg ccggctgccg ctgcgggccg ccgcgatgct gctgcgggtc
     1681 ctccaggagg ccgacgaccg cgccgcgccg cgcctcgaac agctcgtcgc ggcctggagc
     1741 gacgccttcg ccgtacgctt ccgcgcgcgc tgggtccccc tggaggacca ggtcgaacat
     1801 cagtcccgta cggtcgtggc ggcggcccgg cacgcgcggg accgtgcggc gtgacgtccg
     1861 ggctccggaa agagcccgcc gggcgcgccc cggtcagctc cgcagaccgg gcgtcggccc
     1921 gtccgacgcc tgctccgaga gcgcgaacac cgctccggtc tccccctcca acccgcaggc
     1981 gttcccgaag gcgtggcggt actcgacgtg ccgcccgttc cactcgccgt gcgcgtccgc
     2041 ggtcaccggg gcgtagatca tcgggcagaa cgtgcgcttg ggcgggatcc gggtgatgtc
     2101 cccgtcggcg gccgccagtt cctcgcacgc ccgggccgcg tgcgcgtgcc cgtggggcgg
     2161 gtcgcacgtc aggagcctgc tgatgtgact ggagcgggcg tcgcccgtgg tgaccgtcac
     2221 atagagccag ttgccggggg tcacccggtg ggccgccgcc tgggccgggg ccgcgctgag
     2281 cagggcgatc gcggccagca gggcgccggg gaccgccatg gtcgtcttcg tcattccgta
     2341 tgcatcggca cgacggcgtc cgaaccccag cggggctcac ccgaatgcga gcgcacgggc
     2401 gcgtaccgcc ccgcgagttc gaacgcggcg agcaccacgc gcgtctggta ctcgacctgg
     2461 tggccgaccg ggacccagcg cgccccgtag ccgtcgcggt agtcggcgca ccactcgtcg
     2521 atgagccggt ccagctcggg gaggacgtcg gacgccgcgg ctccggcggc cgtggcgagt
     2581 tggcgcagca gcccggcggt ccgcagggcg acccggcggc ccgagatgcc cagcgcggtc
     2641 agccgggcgg tgttgagcgg cggcagcggc cggcccgtgc cgtcgaacgt gtcgggatcc
     2701 caggagtcgg cgagcccggg gccgaccagt aaatagtcgt cgaccggggc gagcagactg
     2761 gcggtgtcgg gggtggcggc gagccgcggc cggatccggg cgaggatgtc ctccagaagg
     2821 cccgtgtcgc ggcgcagggt gcggctgacg gcgcgcagga ccgcgtcggc gtcgccgggc
     2881 ggtgagccgt cctccacagc cgccacgccc cacatgggcg cctcgacgac cgccgtcacg
     2941 gtgccgtagc gctgcgggtg gaaccaggtg gattcgaccg cggcctccgt gatggcggcg
     3001 gccaggtcgc cgcggcgcgg cggtgggatg cggtagacgg cggggcccag gggcggccag
     3061 tacagggtgt cgtaggggcc gagttcgcgc gggatgccga accgggcggc ggtgcctgcg
     3121 acgcgctggg cgaggccggg caggtcctgg gtcagttcga cgaagccgcc gccgacgtcc
     3181 acgccgtgca gggagcactg gaagaagggc cgcagctcgt cctggaggtc gaggagggcg
     3241 cgggtttcgg gcagggcggc ccgctcggcg ccgtcgggca gccactcggg ctgctccagg
     3301 aagcccgggc ggaagaagtg ccggaagtag tggccgaggg tgtacgggcc cgacagccag
     3361 ccctcgttgc ggcgcgcgcc gtcggggtcg aggcagagca gcaggttcca ggtggcgtcg
     3421 gcgccctcgg ccggcccggg gccggccagg acccgctcgg cgaggcgcag ggcggtggcg
     3481 ccgcccacgg gttcgttggc gtgcggtccg gcgacgacga gggcgtggcg ggtgccgtgg
     3541 ccgacggaca gcagccacaa gggcgtgccg ccccgggacg tgcccacgcg gcgcagccgg
     3601 gcgtcgcccg gacggcgggc gacgagcgcg gcagcccgcg cggccagttc gtcgacagtc
     3661 gggtagcgaa ggagtggcgg cagggcgcac ctccactcat gtggtgccgt cggttcacct
     3721 ggtgtgcatg gtgtacgcac agtcagtcac ggctcggcag gtacgtcaac accgcccggg
     3781 gcgagggaag gccgggcgga cacggcacgt gacaccgggg cggggtctcg ctccggcgcg
     3841 gcccgccgtg cacaccgggc ggcgcaacgc gcaccctggt gcggggcgcc gaccgccgtc
     3901 ggctactccg tcgcgagccg aaaggccatg ttcccgaagc tcacctggtc gccgtcacgg
     3961 acgaccgcgg cgccgatcac gtgacgcccg ttcaccgtcg tgccgttggt ggatcccagg
     4021 tcgcgcagca cccacaggcc gccctggcgg ctgagttcgg catgcacacg cgagacggtg
     4081 tcgtgactga gcctcagacc gctggcgggg tcgcggccta tccgcagcgg gtgcgtgctg
     4141 ccggggtgcg gcaggagcag cttggggagc cgctcggcct gccaggccct gcgcagccgt
     4201 acggtgaagc cggagaccgc ctcgaccgtg ccgaacacca gccgcgacac gcgcttctcg
     4261 gcgggcaggt cggcggtgag cgcggccagt tcggcgggct ggcgggcgac cagcgccagt
     4321 tccatgcgcc ggatgaacgt gtcgtgcgag aggcgtccca gggctacgcc gtcgcggagc
     4381 accttcagcg ccctgtcgcg ctcggcgtcc gacagccgcg cggggtacgt gtggaactcg
     4441 aaagacgacg tcacgcaggt gattgtcggg cagtcgggcc agggtgtcca gaaaaccccg
     4501 gaaacggacg tcgtctccgt cagggtcgtt ccgcgtggca aaagggtcga ttcaacggcg
     4561 aattgatctc gattgacgca ccatggactg gctacatcac gatgagcaga cgagggggaa
     4621 ccgtccgtgc agttcgaggt gtgggcacca caggccgccc gggtgacgct ccactgcggc
     4681 ggcgccacgc gcgcgttggc gcgcgacgag gagcgcgacg gctggtggaa gggcgacgcg
     4741 gaggccgggg acggcacgcg gtacgggttc gccctggacg acggtgccgt gctgcccgac
     4801 ccgcgctcgc gccgccagcc ggacggcccg gacgggctga gcgcggtggt cgaccacggg
     4861 cggtacgcgt ggcgtgccga ccggcccggg cgcgggctgc cgggcgcggt gctgtacgag
     4921 ctgcacgtgg gcacgtacac gcgggagggc acgctggacg cggccgccga gcggctcggg
     4981 catctcgtgg aactgggcgt gacccatgtg gagctgatgc cgctgtgccc gttccccggc
     5041 cggcacggct gggggtacga gggcgtctcc ctgtgggcgg tgcacgagcc gtacggcggg
     5101 cccgaggcac tgaagcggtt cgtcgaccgg gcgcacgagc tcggcctggg cgtcgtcctc
     5161 gacgtcgtgc acaaccatct gggcccgtcc ggcaactgtc tgcccgcgtt cgggccgtac
     5221 ttcacggaca cccatcacac gccgtggggc gccgccgtga acctggacgc gcccggctcg
     5281 gacgaggtgc gcgcctatct ggtcggcagc gcgctggcct ggctgcggga ctaccgggtc
     5341 gacgggctgc gcctggacgc ggtgcacgcg ctgtgcgaca cgcgcgcgtg ccacttcctg
     5401 gaggagctgt cgacggcggt ggacgccctc gctgccgacc aggaccggcc gctcttcctg
     5461 gtcgccgagt ccgacctgaa cgacccgcgg ctcgtcactc cccggcacga gggcggcctc
     5521 ggtctgcacg cgcagtggaa cgacgacttc caccacgccc tgcacaccgc gctgacgggc
     5581 gagtcgcagg gctactacga ggacttcgcc cgggccccct tcgcggcact ggcgaagacg
     5641 ctgacgggcg gcttcttcca cgacggcacg tactcgacgt tccggggccg gtgccacggc
     5701 cgcccgctgg accgtacgcg cgtgtccgcg caccggctgc tcggctatgc gcagacccac
     5761 gaccaggtcg gcaaccgcgc ccagggagac cgtctttcgg cgtccctgtc ccccgggctg
     5821 ctggcatgcg cggcgacgct gacgctcacc tccgccttca cgccgatgct gttcatgggc
     5881 gaggagtggg ccgcgggcac cccctggcag ttcttcaccg accacaccga tcccgaactc
     5941 gcggaggccg tacgccgggg caggcggcgg gagttcgcgg cgcacgggtg ggccgaggag
     6001 gacgtccccg acccgcagga cccggcgacc cgcgaccgct cctgcctcga ctgggcggaa
     6061 ccggaaagcg gcatccacgc gcgcgtgctg gcctggtacc gcggcctgat caccctgcgc
     6121 caccacgagg cggacctctc ggaccccgac ctcaccgacg tcaaggtcgc gtacgacgag
     6181 gaggcgcggt ggatcgcctt ccgccgcggc gacgtacgcg tggccgtcaa tctgtccaag
     6241 gagcccgcgc ggatcccgct cggtctcgcc cacgcgcgcg tgctggccgc gtgggagccg
     6301 gtggagaccc cgggcgcgga cggggtactg gagctgccgg gcgagtcgtc ggtggtgctc
     6361 acgcaggcgt gacgggcggt ggcgggtggg ttggggcggc gcgtatgcgc ttgcgtaaac
     6421 gcttgcgcaa gcgtttacgc atcgtccgtc acgtcacctc tcgccgcccc gccggacagg
     6481 tctagagcgt ctcgtccccc ggcagttccg tgacccgttc caggaggatc gcctcccagg
     6541 cgcgccgcag tcgggtgcgc agaagcggga gggggctgtc gtcgcgtccc tggagacggt
     6601 cggcgaggcg gacgagggtg tcgcagcggg tgagccacag gccgcgcaga caggggcggg
     6661 cgccgtagcc ggcgagggtg gcggcacgta cggcggcggg ggcgcccacg gcgatggcca
     6721 gcccggcgat gtcctcggcg gggtcgccga tcaccgcgtc ggtccagtcg aggacgccgc
     6781 gcacccggcc gtcgccgctc accacgaggt gttcgccctt gagggcgtgg tgcacgagga
     6841 ccgccgcacc gggctgcgcg gcgagctgca ccgccgccgg cgccgtgagc tgaccgaggc
     6901 ggtccgcgtc gaactcgtcg gccccggaga ggtactgggc ggcgtcctcc gcgaccgtcc
     6961 gcagcgcttc gagggaacgc ggcaccgcgc gcgggacgcc gagcggctcc gcctgtcgta
     7021 cgggcacctc gcgcaacccg gtgagcagcg ccgcgaggtc cgcctcaccg accgccgaga
     7081 cggcatgctc ctctccgccg gcgccgggca gcctggtgtc gagggtgtag gccagccccg
     7141 tggcccactc gccgtgcgcg acgctcgccg ggaccgcgac cccgatgtgc ggccggacca
     7201 ggtcgcgcag ccgcagctcg cgacgcaggc gtacggacgc gtcacggtcg ggggcgagcc
     7261 gcagcacatg gcgcgtaccg acccaccagg tggagtgctc accgcccgcg gcgacgggcc
     7321 gcacctccgg tcccgctccg tccgcggggc cgtcggcgag cacggaacgg accagtctgc
     7381 ggatgctgtc cgccgtcggt gtcggtgcct gggtcatggt cgcgccgttg tcgtctcggg
     7441 ggcgtgaggg gggtggtcgg tcagtcgacg atcaccagct cgcgggaggt gttgttgagg
     7501 cggcgtccgc cgtcgtcggt caccgtcacg atgtcctcga tgcgtacgcc gaagcggccg
     7561 ggcagataga cgcccggctc cacggagaag cacatcccgg gtacgagggc ccgctgttcg
     7621 ccctcgatca tgtacggcgg ctcgtgcgtg gtgacgccga tgccgtggcc cgtgcggtgg
     7681 atgaagcggt cgccgtagcc ggcgtcggcg atgaccgcgc gggcggcccg gtccacgtcc
     7741 tggcaggcga cgcccggtcg caccgcgcgg aagcccgcct cctgggccgc gcgcaccagg
     7801 tcgtgcacct tgcgctcctc ctcgtcgggc tcgccgacgt ggaccgtgcg cgaggtgtcg
     7861 gagccgtagc cgtgcttgag cccgccgaag tcgaggacga ccatgtcgcc gcgctcgatg
     7921 acgcggtcgc ccgcctcgtg gtgcggattg gctccgttcg ggccggagcc gaccaccgtg
     7981 aagtcgacct gggagtgccc gaactgccgt agcagttcgg cgagatcggc ggcgacgtcc
     8041 gtctcacggc gcccggcgaa gggaaccttc cggatctcct cgaacgtggc gtccgcggcc
     8101 gcgccggcgg ccgccagccg ctccagttcc gcggcgtcct tgacggcccg cagcatcggc
     8161 agcgcctcgg tgagcgcgac gtagcgcgtg ccgggcagcc ggccgctcag gccgagcagg
     8221 tgcatggccc aggcgttgtc gctgatgccg aagcggccgg accggtcgag gagggtcgcg
     8281 gccgcctcgt acgggtcctt gccgtcggtc cagtcgcgca gcgtcagcgc gggcgcgccg
     8341 gccgcctccg ccgcgtcggg cgcctccagg gtgggcacga ccaggacggg gtcgtgtccg
     8401 gcccgcagca ccagcagggt gagccgctcg gtctcgaccg gccggtaccc cgtcagccac
     8461 accaggtccg ggccgggtgc gaccagtacg ccgtcgagac cggcgtccgc ggcggactgt
     8521 gccgcgcgcc gcatccgggc cgcgtagtcg gcggcggtga agggtgcggg gtcgccggtg
     8581 ccggggggcg cgggcgtgcc ggtcatccat ggcctccgta ggtcgcggtg tcccagggtc
     8641 tacgggcagc atcctccccc tccgacgggg cgtgcgcgag ccgattgcgg tgccggggtc
     8701 gacttcccga gacaatatga gagtgcctct cacattttac gaaagggtgc cttcacggcc
     8761 cgcgacggcg accggctgcc gacacacgtc ggggcggctc cgccggtgac cggacggcac
     8821 ccgcggcatc cggcgggttc gggctggtcc gtggcgccga ggctcgacgg gcgaaaaggg
     8881 ccggtcggcc gcacgagtgc cgtccgagca gtcggtcgcc cgctccgccg ccctgccgcg
     8941 ccgcagggca gccgagaccg aaccggggct ccgccccgat ggtgcgggct cgcgtcgtcg
     9001 tgccggccgg cggcggccgt ccggcatctc cgggctcgcg gggcatgatg cggcagccga
     9061 cgccgtggct acgtacgagc cccccgcgac gagtagcggt tgacgagtca cctccccgtc
     9121 gcggctacgt gacgatcccc ggtgtcgcca tcaactgctg ctggttgccg ttggcgtgac
     9181 gcaccgtcag tgggactgcc gtgccggggc gtgcgcctgc caccgcccgg gcgagatcgg
     9241 cggccgagtc gagacgggtt ctgccgaagg cgagcaggat gtcgccgcgg accaggcccg
     9301 ccgtgtagcc cggaccgggg gcatggaccc ccaccacgag agcgccattg gacgcggcgt
     9361 ccacggcttc gacgcccagg gtcgccttgc ccggcgcgag cacggcgttc gcactgctgt
     9421 cgccctgcgc ggacttggcg cccatggact gcggtccgcc ggacaccgac gcccccggac
     9481 ggccggaggc cggcggaacc agaggacccg acggccccgc cgctcccgca ccgcctcccg
     9541 cctccgctgc aaatccgcca gcttgctatc cgatcacggt cgcgcccacg gtgccgaggc
     9601 cgatgcccga cagaacgagg accgtcccga cgaacacggc gaagagcagg gtcgtcagcc
     9661 gcttgccccg tcggggcgga gcggcatggg ggcgccgggg ggtgccggac gctcgatcgc
     9721 caccggactc ctggcccggc atcggtttgg gacgcaacgc agtctgttcc atggatcgcc
     9781 tccacagatg ctctaccccg cgcgtcggcg caccacgatc cacgaacgag tgagactggg
     9841 cccgcgtcac ctcgacaccc tggcgggcgc cggcggcgcg ggccgcggtc cggcatcccg
     9901 cgcagccgca ccccaaggcc acccgtcccc ctccggatcg ggcacacccg acacctgact
     9961 gcgcccctcg ccgacgagcc gcagccgcct gtcccccccc tcagcgcgcc accggcgccg
    10021 cccacgcggt gaacggtgcg gaaggtgccc ggtccggtac gaagccatgg gcacgccggg
    10081 ccaggtccgc cgcgccgtag cggtggcagt cctggtgcca cttcaggatg ccggacatcc
    10141 agttctgcaa ctccacgaca tagccgtcca tgatgtcccg cacctcctgc gggagcttga
    10201 agtccttgta gaggagcggc agttcatggg cggccacgtg ctcgaactgg tgcatccgct
    10261 gggtcatcag gtcgttgatg acgccgagcg cggtcgggta gtcgcagccg aagaagttct
    10321 gcacgacgag gatcgcgttg tgcacctcgc cctcgtactc gatctccttc tggtacgaga
    10381 agacgtcgtt gatgagcatg ccgtagtcga cggccgcgtt ctccagagag cggacggggc
    10441 cgctgcggta gatctcgggc gggaccttcg ggccgtggcc cacgcggcac aggctcaggg
    10501 tgaggtcggc cccgaaggtg gcgcggcgca tctccaggta gtcgatcggg tcggggatgc
    10561 ggtgctggag ctggttggac agctcccaca cccagctctc ggtcatcacg tccaccgagg
    10621 cgcggaacgt gcgccgctcg tccggggtca tctccgccgt cgtaatggcc cacaggtcga
    10681 tgaggccgcg ctccatgccg ttgaccggcg ccgggacctc ctcgccgtcg accggcatgc
    10741 acgccgacag ccgtcgtgtg cacagcttgg cggccgcgag gtcgcggcgc ggcccgaaca
    10801 ccatcgggta gtagtcgtcg ccgtacgtgc cccaggccag ccaccgtgag ctgaggtcga
    10861 gttcgtcggg cgtggcgtcc ggatcgaggc cggccgagca cagcggcagg tcgtacgccg
    10921 tcagcttgtc ctcgtcccag acgccctcct ggagcatgcc cgtgctgtgc atccacgggg
    10981 tcagccgggc gcgggcgccc tccaggtgcg ggctgagttc cacctggaac ggcatatgga
    11041 agtcggggat ccgggacggt ccgaccttct ggaacggcac gtgggtgtat cggcgcagcc
    11101 gctcggcccc ggcgtcggcg agcagtccgc gcaggtcggc ggcggaggtg ccgatcgcgg
    11161 agagcccgaa gggccgcttc tgggagaggg cgccctcgtt catgtagcgg ctggacctca
    11221 gatgccattc gtggccgccc gactgccagt cctgaagtcc ccgcgcgtac gccgcgaccg
    11281 ccgcgacctc gggtggggtg aggcctttct ccagggccag cgcgggcact tcggtgagcg
    11341 ccgtgtgctc gaactggtgg agccgcgagg tgaggatgtc gttgacggtc tcggcggcct
    11401 cctgcgtcgt acagccgaag aaggtctcca ggacgaggac gccgttgctc agctcaccct
    11461 cctcctcgac ctcccgctgg tacgagaaca ggtcgttgcg caggtgcacc ccgtcggaga
    11521 aggtctccat cagcacccgc agcggcctcg acccggcgac ggcggccggc acttcggcgg
    11581 tcgcgtactc gacgagcccc gccgaccagg gggctccgcc gaccttgcgg cgcatctcga
    11641 tgtactcgac ggggttggcg atccgcccct cgttgatgtt ggacagctcc cacagcgact
    11701 cgttgagcag gtgctcggtc gagacggcga accgcttgcg ccagtccgcc gacatcgcgg
    11761 gcaccgtgcg cgcccacagg tcggcgaggc ccgcctcgac cggattctcc ggctccggaa
    11821 cgggtgccga caggtcgagc ggcatgaaga gcggcagccg gtccagatag gccttgccgc
    11881 cctcgcggtc ctgggtgcgc ttgaacgtct ccaggaagtg gtcgtcgaag aagaacaccc
    11941 acacgtacca gtcggtgatg agcgagagcg ccgggccgtc gcagtcgggg tgtgtgtacg
    12001 cgcacagcag cccgtagtcg tgtgcgtcga ggtcggactg ctcccagatg ccggagccct
    12061 ccagcatgcc catgccgcgc gcccaccgcg tggagtgggc gcgcgcctcg tcgagatgcg
    12121 ggttcagccg cgcggggtag ggcatgtaga agtgcgggag ttggaacggc tgcgtcatgg
    12181 ccgggcccta cccagggccc ttcggggaca tccgcgggcc gggacatgat cacaccatcg
    12241 cgtgaatcgc gggcgttccc gcccggccgt cccacgcgtg cgtgccccgg ttccacgcct
    12301 gcccgccgca gttccgcgcc tgcctgcccc ggtgccacgc cctcttgcca cccctgcccg
    12361 gccgggtcac cgtgacagca tgacctcctt cgtgctgccc catgaactgc acggcgacgg
    12421 cgcccacaag gtgttcgcgg tgcacggctg gttcgccgac cgggccgcgt acgcggcggt
    12481 gctgccggat ctcgaccggg ccgcgttcac gtacgcgctg gtggatctgc gcgggtacgg
    12541 aagggccaag gacgcggtcg gcgcgttcac caccgccgag gccgccgcgg acctcgtcga
    12601 gctggccgac cggctcggct gggatcggtt ctccgtgatc gggcactcca tgggcggcac
    12661 ggtcgcgcag cggctgctgg ccctcgcccc gaagcgcctg cgccggatcg cgggggtgtc
    12721 cccggtgccc gcgtcggggc tgtcgttgcc ggccgaccag tggcagctgt tcgcggacgc
    12781 ggcgcacaag ccggagaacc ggcgcgcgat catcgacgtc accaccggcg ggcgccgccc
    12841 cggggcctgg ctcgaccgga tggtcgcccg ctccctcgcg gacagcgacg cgaaggcgtt
    12901 ccgggcgtgg ctggactcgt gggccgggga ggacttccag gcggaggtca cgggcgcggg
    12961 ggtgcccgcg ctggcggtga cgggggctct tgacccggcg ctgtcgagcg cgctgctccg
    13021 ggacacctgg atgcgctggt acccgcgcgg cgagctgagg gagctgccct cggccgggca
    13081 ctacgccatg gacgaggcgc cgctcgacct gatccacgtg gtggaggagt tcctccgggc
    13141 cgaggacgcc ggcgagtgag cgtccgcgag caggccccgc ccgtccccga tgtcttcgac
    13201 ccgcgccggt acgccgccgg agtcccgcac gccgcgtacc gcacgctccg cgaccatcac
    13261 cccgtcgccc ggcaggccga gcccgaggtg ctcggctggc ccgccgggcc ggggttctgg
    13321 gcggtcaccc ggcacgcgga cgtcgtacgc gtgctcaagg actccaccac gtactcctcg
    13381 cggttcggcg ccacccagat ccgcgacccc gatcccgacg acctgccgtt catccgggac
    13441 atgatgctca atcaggatcc gccggaccac ggcaggttga ggcggctggt cagccgtgcg
    13501 ttcacgccgc gccgcgtcga ccggttcgag tcgctcgccc gtgaccgcgc ccgcaccctg
    13561 ctcgccgccg ccctcgcggg tgcgcgcgcc ggcgacggca gctgcgacct ggtcgccacc
    13621 gtcaccgacg actacgccct gctcaacctc gccgatctgc tcggtgtacc ggagagcgac
    13681 cgcggcctgc tgctgcactg gacgcggcgc gtcatcggct accaggaccc ggacgaggcg
    13741 ggcgagccgc tcctcgacgc ggcgggcaaa ccggtcgatc cgcgctcacc gggggccctg
    13801 cgggacatgt tcgagtacgc gcggcagctg gcctcgtaca agagggaaca ccccgccgac
    13861 gacatcatga cgaccctcgc caccgacccc gaactcaccg gccccgagct ggcgatgttc
    13921 ttcttcctgc tgacggtcgc gggcaacgac accgtgcgcg gcgccgctcc gggcggcctg
    13981 ctggccctgg cggagcaccc ggaggcgtac gcccgactcc gtgcccggcc acagcaacta
    14041 ccctccgccg tagaggagtt gctgcgctgg catccgcccg tgctcacctt ccgccggacg
    14101 gccgtacgcg acaccgacct cgccggacag cgcatccggg ccggcgacaa ggtcgtcgtc
    14161 ttccacgcct cggccaaccg tgacgggcgc gtcttcaccg ccccggaccg gctggatctg
    14221 tcgcggtcac cgaacccgca cgtctccttc ggcgacggcc cgcatgtctg cctgggcgcg
    14281 cacttcgccc gcctgcaact gcgggtgctg tacgcgcaga cgctacgggc gctgcccgca
    14341 ccgcgggtcg ccgggcctcc cggacgcctc gtgtcgaact tcatcaacgg gatcaagtcg
    14401 ctgccgttgc aggtggcatg aggggtgcgt cagggcctgg cctggatcac cgcgtgcgtc
    14461 ccgctcgtgc gccatccctg cccctgggcc gccgccaacg ccgcctccgt gtccgcgtcc
    14521 aggccgacga tcacgtccga tttgagggtg cgcagggcca cgaccgggcc ggggaagtac
    14581 gccgtcgggg tggtgaacgg tgtcgtcggg ggccagagcc ggtcgcccac cagacggcgg
    14641 tagttgaggt cgcccttcat gatggtcagg tccgcctcgg cgaactcgcg gcgcaggtcg
    14701 tccggcatgt ccgcgtacgg cagcggcgca caggagaaga catgggcccg caccacgagg
    14761 cggccgtcgg tcagggccga ccacaggcgg tccccggccg ccccggccgc ccccttggtg
    14821 ccggtcagcc gccgtaccgc gtccaggacg tcggcggtcg tggcgtccga gacgaagtac
    14881 gggtacggct tcacgtgcag caccgcccgt tcggcccgcc cgtggtgcag gagatggtcg
    14941 atcaggagca ggtccgggat gagctcgcgg ccggcgttgt ccgcgaccag acagaccgtg
    15001 cgggccgggc cggccgtgcc gtcggcgtcg gagtcggagt cggagtcgga gtcggccgtg
    15061 tgcgccggca gcagcgccca cagtgactcg ctgtcgtcca cgaggagttg ggagtcgacg
    15121 gagccgtcgc ccccggcgga gatgcggaag ccgaggtccg cgcggttgcc ccagagcgag
    15181 ccgtggagca gcgcccgcgc ctgttcgtcc agcggccgtc cggtgagcgc gtcgagcgcg
    15241 gccagttcct cggccgcctc cggggtgtcg agttcggcga gcttgaaggg gcggaagggg
    15301 tcgatgccct gccagggccc tgagccgaag tagccgacag ccgcgaggag ttgtcggtag
    15361 aagtagctct cggcccacag gaagggcacc gagaaccagg agcggccgag gtgcttcgga
    15421 agcccccagg ccacccaccg ctcgtggtcc tcggccggtg tgccgagcgg ctcgatcaca
    15481 ccgtcgaggg cgctcttttg cagcgcgtcg agcgcgcgcc gctgctcggg cccgtacggg
    15541 aaggcgtccc gcaccttgcg gatgagcgcg gggtgccgct cggccagcac gctgtgcggg
    15601 aaggatcccg ggtcgtcgct gacgatcacg ggggcttcag acatggtcct gtgctccttc
    15661 gggaccggtc cggatgccga caggcagctc caggtccctg accgcggggt ccagctgctt
    15721 cccgtatccg gcctcggtcc acacgtactt ctggaactgc tccggcgtca gcagaccctc
    15781 ccacgggccg ccgccggggc agaacaccga cgcgcacccg gagcagtagt gcgccggacg
    15841 ccacagccgg tcggcgcggt gctctccggc gttcaccacg tcgcgctcgc gcgcctcgcc
    15901 gcggaccacg aggatcgtgc cgacgaacag cagcacggcc agcagcgctc cgccgatcgt
    15961 gtagagcggc ttgtcgttgt ccaccccgct gtacgcgagc gcggcgccca cgccgaccat
    16021 cagcatgccc tcgacgaagt gcagacagcc gtcgaatccc gacgtcacgc ccggcgcctt
    16081 cgccaggcgg ttggacaggc cgtcgcgcac ggacgcctcg tcggcgcaga tctcctcgac
    16141 cgcgcgcacc gtcgattcgc cgcagctcgg acatatcact ccgactggcc cgtgggccga
    16201 ctcagttggc atgcgcatac gctaacggcc ggccggcgca cacgctgtcg cgcgggccgg
    16261 tgtcccgcgc cgccacaccc tggacgcgca gcttccgggt gccgctcgcg gtggactgaa
    16321 cgcacggcat cgcatccccg tactcctctg gtacgcgctc ccccaccggc cgaggagact
    16381 cccggatgac cgcacaccgc accgccgccg cggccgccgt agccgtggcg gccccgctgc
    16441 tgctgaccgc ctgggcggcg ggtccggccc aggcccatgg cgcaccgacg gatccggtca
    16501 gccgggtggt ggcgtgctcc cccgagggcg gcggccgggc gcggaccgcc gcctgcacgg
    16561 cggcgatcgc ggccaacggc tcgcccttca ccgcgtggga caacctccgg gtcgccggcg
    16621 tgaacggcag ggaccggcag ctgatcccgg acgggaagct gtgcagcggc ggcctgcccg
    16681 cctacaaggg gctcgacctc acgcgctccg actggccgtc gacacggctg acccccggcg
    16741 cgtcgctgac catgaagtac agctcgacga ttccgcacac cggcacgttc aagctgtatc
    16801 tgacgaaaca ggggtacgac cccacgaagc cgctgacctg gtcggacctg ccggcgcagc
    16861 cgttcgcgca gctcaaggac ccggcactgg cgggcggcgc ctaccgcctc ggggcgaagc
    16921 tgcccgcgga ccggaccggg cgccatgtgc tcttcaccat ctggcagaac accagcacga
    16981 cggacacgta ctactcgtgc tcggacgtgg tcttcgcgaa ggccaaggcc gccgccggtg
    17041 cgggcggcgg atcgacgggc gccgccagga agccggccgg caaggcgact ccgagcagtc
    17101 ccgccgccac gtcctcaccg tcgagctccc cgtccccgag caggtccgag accgccgcct
    17161 ccacgccgcc gccgtccagg accgccgtgc cgggtactcc ggcggcggcc accgcgcacc
    17221 gttccgacag cggcccgtcc ctgcccctgc tcgcgggcgg cgccgcggcg gtggtgctcg
    17281 ccgcgggcgc cgtcgtgagc ttgcgccgcc gtcgccgcta ggaggtcgcc gccaggggac
    17341 ggacaccccg tgtggggcgt ctcctggcgg cggcccgcgg gccgccgcca ggccgtcgcc
    17401 ggacccttgc cgtcagaccg tcgtcatcag gccgtcgccg tcaggccgtc gtcagttgac
    17461 gaagaccgac gggctgccgg acacgctggt gtccttgacc ggggcgtact tcgcggtgaa
    17521 gtagccactg ctgaagcaca gggacgagcc cgaggtcttg gtgaactgct ggttggtgaa
    17581 ggtgatgctg ttgtcggtgt tgctcgccgt gcccgacagg ctgggggcct ggtagacaca
    17641 gttgatggtg cccagcaggg tgctgagctt gacggtggtc tggatggtgg agccgctggc
    17701 cggagtcacg gtgacggttc cgtcggagcc cacggtggtg gtgtacggaa ggttgttgac
    17761 ggtgacgccg ctgacgccga ggacaccgat gacattgctg gtgcaaccgt cgaaggtgtg
    17821 cgcggtgacc gactcggtgg ccgtgccgga cgcggccggg ttgtccacga caccggcggt
    17881 gaaggtggac gcgctgcagg agacgccgct cgtgccggtc gcgctggagt agagcgtggc
    17941 cgcggtgccg gtggccagcg aggcgctgag cacgtcaccg gtggcgacgg cgtcaccgcc
    18001 ggcgctgccg gtggtcagga ccgtgcctgc cgcggaggcg ggcgacatcg ccgagaccga
    18061 gagggccacg acgacgccgg cgagggcaag caagggtcga gtgcgcatgg gggtgcctct
    18121 tctcagaagt gtggagctgc tgcgggtgac cgcgcccctc ggggatgcga ggggacgcgg
    18181 aggtgcggct gccgccgccg gcccatggcg ccttctccgt acgcgacgga ccggcggcgg
    18241 cagccgggcg accggacacg gcccaggcga tgggaaggcg accgtgccgg cgccgcggtg
    18301 ggggtgatgg atcactcgga ggtggtggag accgcgcatc gtggtggaga ccgcgcatcg
    18361 tggtggagac cgcgcatcgt ggtggagacc gcgcatcgtg gtggagaccg cgcatcgtgg
    18421 tggagaccgc gcatcgtggt ggagaccgcg catcgtggtg gagaccgtgc gtcgcgccgc
    18481 gcgtccagaa gtgccgccac cgccccggga cagccagggg ccgggagagc gactcgcgcc
    18541 gtgcgacgga tccggcgcca cggatccttg ggaaagcagg ggaatttgta aacctgatga
    18601 gcagtcaacg tcaagacgta gcaaggaagt tggcggctcg cggcggagaa gttgacctgc
    18661 ggtacacctg gtgacgcaca ggtgtcacac aaccatcacc cttttcgcac aagttgcttg
    18721 accctgaact gtaaccaccg gtaacttcca ccgcggctac tgctgcgtaa cgagaaagcc
    18781 cttgcgctcg ccgggaggtg cgaggaggcg tccgcggcag ccgctgtccg cgccaggaca
    18841 acgtgccagt gaaaccgcac ctgcattgac tatgcccagg agcagacatg gcctcatcct
    18901 cggacgccac ggcgtcccac ggttccaccc cccagacccc ggaaagcggt tccgccgccg
    18961 aagggtccga aagacgcggg cgggtccgcc tgcgccgcgc cgcggtgatg gcggtgcctg
    19021 ccaccgcgat cgccgccgga ctggtgatcc tcaccgccca gggtgccctc ggggtgcagt
    19081 tcgccatatc cggcatgccg ttcacggtca ccgccaccga cctgaacggc accggcttcg
    19141 agcagttcgg caacctcgac aacatggccg agggcagccc gaacgccggt gacaccggcg
    19201 gccaggtcct ggtcgtcacc tccgcgatca aggacgcgac cctcaccaag ctgtgccaga
    19261 gcgtcgacct cggcggtacg aacctgcgga tcgaggcggg cgccggcaag gacaaggtgg
    19321 tggcgagcga tctgaccacc gactccaccg agctgtccgg cgacgccgag ttcaacaaga
    19381 tcgagatcgg caacgacgcg agcacgctcg acaaggcggg ggtgcagggc aacaagggcg
    19441 tcttcagcca gcaggccgac accgtgcata tcgccaatct ccggcagacc aactacgcga
    19501 ccacggcggg ggtgttcaag cttccgggcc tgcacctcag cttcagcgac aaggcctgct
    19561 gatggcatcg cggccgaggt ccgccttcag gcggtggcgc gcgagccgtc ccttctgggg
    19621 cggactgctg ctcaccctgg gcggtgcgga ggtcctcctc accgagaagg tgtcactgaa
    19681 ggtggtcatg cacatcggca tgcagggcct cgcgggctat ctgctgccgg tcgtcatgat
    19741 gctgtgcggc ctgctgatcc tcttcaaccc cgcccagcgg ctcttctact ccgtcatcgg
    19801 catcctggtg accctgggca cctggctcac gtccaacctg ggcggcttct tcatcggcct
    19861 cctgctgggc gccacgggca gctgcctcgc cttcggctgg ctgccggacc aggaaccccg
    19921 ccggcgcctg ctgcgccgcc atcggacgcc gtcccccacg gccgattcgc ccgcgtcctg
    19981 acgccaccgc tcctcggcga gcgggctccg ccgaccgccc cccgcggcac cccgaggtcg
    20041 tccccaccgg aacccgctcg ccgagcccgt ggccatgggc cggggccccg gcggtcgtgt
    20101 ggtcgtccgg cccgcggcct cgccgccaag agcgcggcgc gcagacgcgc cggtacagcg
    20161 acggtgcagc gacggtacgg ccacatgaca cgtacggcgt ccgccggcgt ccggcgggca
    20221 gggcccgcac ctagtcgccg ccaggggccg catccaccgc ggggcactga ccccagggac
    20281 ggtggtactc agcgcttcgt gcgggcggtc accgtgaagc gggccccgtc ggggtcgctc
    20341 agcaccgcct ccgtggcgcc gggctcccac cgcagcaccg tgccgccgtg gtcctgggcg
    20401 gcatggacgc aggcctcgac gtcgtcgacc gcgaagtgga cctgccagtg cggtctgagc
    20461 tgggggtcgg gcgcggctcc caccgccccg gagtggatcc gcgccaccac gtcgccctgg
    20521 ctgagcagta cgacctcctt cccgtcgtac tggacctgac aggcgccggg gcgtgcggag
    20581 gcccattcga ggacctcccc gtagaagatg gcggcgtcga aggcgtcgcg ggtgtggagg
    20641 cgtacgaagg cgggggccgc gcggcgccag tggtcccagc cggcgacgag ctgtccctcc
    20701 cagatgccga agacggcacc gtcgcggtcc gccagcaggg ccgcccggcc gggcgggaag
    20761 gcgatcggcc cgaccgcggt cgtaccgccg cgctcctgac tgcgggacac ggcctcgtcc
    20821 gcgctgggca ccgcgaaata cggcgtccag gcggccgcca tctgccactg cgaggccacc
    20881 gcggcgatcc cggcgacggg catgccctcc gacagcgcga agcggaaccg gtcgccgagc
    20941 ttgcccgtgc gccagcgcca gcccagtacc gccttgtaga agttctccgc ggcttccagg
    21001 tcgcgggtgg tgaggctgac ccagcacgga gcgccgaaca ccgaatggct ggagacgatc
    21061 tctcgcgcga gcgttccgtt tcttttcatc gctctaccgt cctgtcatct ccgccgccgc
    21121 tccgcaaccc ggaggccccc gagaggcccc gtagtcccgg ccccgggtac cccgcggaca
    21181 tcggggcaaa ctccacagac cggcacggct cacggccgcc gcagggccgt actcagctca
    21241 cggccgccgc aggaccgggc tcagctcacg gcgcccagcg accagctcgg gctgattccg
    21301 gcgagccggc agatgaggaa gtacagcggg atcggtggcg tgtacggaga gtcaccatcg
    21361 ggacggtgga tgaggcgggg accgccgggg cgggggcggc ccgatgcccg ggtccaggac
    21421 gggtcggcca gataggcccc gatcgcgtag gtcgtgcagg acggccaggt gacgcccacg
    21481 tgggagccgg aggggacgat ccaccaccag cgcaggtcgt cggcgaagac acagccgacg
    21541 cgcgggaggc actccatgat ccgctcgccg tgctccggcg aggtgcccac ggcgtcgtag
    21601 ccgaggccgg ccggcagttc cacggggagg gagagccgct gggggcgctc gcacagcagc
    21661 ggggcggaca ggccggggcg gggatcggac aggcgccggt gagcgtcgga caagcgcggg
    21721 cgagggtcag gcgtgtgctg tcggtccatg ggatgacggt ccttcggcca ggtgggggac
    21781 gggccgggtg gtgttcgtgg tcgccggaag cccggtcgag gcggggtctc ctccgtccgg
    21841 cgacagctcg gcccagacga tgtgtccggg cccgtacgcg ctgttcttga cgccccagtc
    21901 gccgctcagc gcgccgacca gcaggagtcc gcgacccccc tggtcgtcgg gctccggccg
    21961 gcactgggcg gggagggtct ggccccggtg ctcgtcctcc acctcgatgc gcacccgcgc
    22021 gccgtcggtg cgcagtctgc acacgatccg gccgctggcg gtatgcatga tcgcgttggt
    22081 gacgagctcg gaggccacca ggacagcgtt gtcacatgtc tcggcgtcgg tgttccaggc
    22141 ggcgagcagc tcgcgcacat ggccgcgggc cacggcca
//
