LOCUS       NC_003155              31112 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2427882
            Orig. end                         :: 2458994
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..31112
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="13"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..31112
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..31112
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[14000:17112]"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      14001..17112
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     gene            complement(853..2220)
                     /db_xref="GeneID:41539091"
                     /locus_tag="SAVERM_RS10480"
                     /old_locus_tag="SAV_1990"
                     /old_locus_tag="SAVERM_1990"
     CDS             complement(853..2220)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539091"
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431808.1"
                     /locus_tag="SAVERM_RS10480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1990"
                     /old_locus_tag="SAVERM_1990"
                     /product="histidine kinase"
                     /protein_id="WP_242432230.1"
                     /transl_table=11
                     /translation="MSSDKPAPSPGASTYRAVFERMVPARSGPRPPGLPEPAVPLSYGL
                     PRQRWFLPSAVIAALDAGGAERGRHPRRTVRDWIVDLGCVLLAVVIGIAAAEAVTREHD
                     IPHGLAVADQWLGASACAAVWLRRRRPLGLAVAMMPVGLISNTAGGAGLIALFTLAVHL
                     PFRYVAWVGGIQLALLPGVYWLRPDPDLPYVAAVAVAGLLTVTVVGWGMFVRSKRQLVL
                     SLRDRARRAETEAELRAEQAQRLAREAIAREMHDVLAHRLTLLSVHAGALEFRPDAPRE
                     EIARAAGVIRESAHEALQDLREIIGVLRAGDADDAGRPQPTLAALDGLVAESREAGMKI
                     VLDHRVTAPAAVPASIGRTAYRIVQEGLTNARKHAPGAEVTVTVAGAPGDGLTVSVRNP
                     APPGDVPHVPGSGQGLIGLMERATLAGGRLDHGAEGDGGFGLRAWLPWPGPGPDPR"
     gene            complement(2508..2903)
                     /db_xref="GeneID:41539092"
                     /locus_tag="SAVERM_RS10485"
                     /old_locus_tag="SAV_1991"
                     /old_locus_tag="SAVERM_1991"
     CDS             complement(2508..2903)
                     /codon_start=1
                     /db_xref="GeneID:41539092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071217.1"
                     /locus_tag="SAVERM_RS10485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1991"
                     /old_locus_tag="SAVERM_1991"
                     /product="ribonuclease"
                     /protein_id="WP_010983431.1"
                     /transl_table=11
                     /translation="MRFPPRITRISAAAALLSALLVGGTVSATTADATAASVGSICYSD
                     LPSQAYDTLDLIESNGPFPYSQDGAVFQNREGVLPTQSSGYYHEYTVKTPGSSTRGARR
                     IVTGKQTQEDYYTSDHYVTFDLIDFDC"
     misc_feature    2977..2991
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.73"
                     /tool="antismash"
     gene            complement(2990..3895)
                     /db_xref="GeneID:41539093"
                     /locus_tag="SAVERM_RS10490"
                     /old_locus_tag="SAV_1992"
                     /old_locus_tag="SAVERM_1992"
     CDS             complement(2990..3895)
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539093"
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071207.1"
                     /locus_tag="SAVERM_RS10490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1992"
                     /old_locus_tag="SAVERM_1992"
                     /product="DMT family transporter"
                     /protein_id="WP_010983432.1"
                     /transl_table=11
                     /translation="MSSIAVPGALAPRRAWLTDLPVLLVAVVWGASYLAAKDITTARTV
                     IAVLVLRFGVVLPVLVIAGRRSLRALSAAQWRGAALLGLILSGIFLLETYGVVHTSATN
                     AGLIISLTMIFTPLAEAAVTRARPPRAFLAAAGVSVLGVVLLTQGGGFTRPSLGDLLML
                     LAALARTVHVLAMSRVKSVQGADALPLTTVQLGAAVAVFAVLSTGTDATVWGTAAGFGA
                     REWGGLLFLAAFCTLFAFCVQMWAVRRTSPSRVSLLLGTEPLWAAAAGITLGGERLGAL
                     GLMGGVLVLAGTAWGRRAAG"
     gene            complement(4021..4629)
                     /db_xref="GeneID:41539094"
                     /locus_tag="SAVERM_RS10495"
                     /old_locus_tag="SAV_1993"
                     /old_locus_tag="SAVERM_1993"
     CDS             complement(4021..4629)
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236850.1"
                     /locus_tag="SAVERM_RS10495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1993"
                     /old_locus_tag="SAVERM_1993"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_010983433.1"
                     /transl_table=11
                     /translation="MGKLTLTAFVTLDGVHQAPGGPEEDRSDGFEQGGWSVPYGDEDFG
                     RFVTDAFARVDAFLLGRRTYEIFAGYWPKVTDPADPIAAKLNSLPKYVASSSLTDPAWS
                     GTTVIRGDLAKEVAALKERTARELQVHGSGALARSLLALDLIDTVHLLTFPVVLGAGRR
                     LFAEGAVPTAFRHVFGSTTGAGVAIHTYERAGRPTYGSY"
     misc_feature    complement(4598..4613)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.43"
                     /tool="antismash"
     gene            4827..5834
                     /db_xref="GeneID:41539095"
                     /locus_tag="SAVERM_RS10500"
                     /old_locus_tag="SAV_1994"
                     /old_locus_tag="SAVERM_1994"
     CDS             4827..5834
                     /codon_start=1
                     /db_xref="GeneID:41539095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735326.1"
                     /locus_tag="SAVERM_RS10500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1994"
                     /old_locus_tag="SAVERM_1994"
                     /product="CorA family divalent cation transporter"
                     /protein_id="WP_010983434.1"
                     /transl_table=11
                     /translation="MIVSVVSMPEGVVARTGLTQAREHLASSRFVIVDVDQEEEPPLDD
                     EPLSRRLGLDDAAWKWLGRPDEHVRVEYHAGTAAGVVPVVCGNQVIHIHVLAGDRHFIT
                     IHQGPVELIDTFIGQLPQDRPPDAVTTLFLFLQGVLETYRRAITQAHLEVEDLEEAMFE
                     QRQPEQVRRLAQLRQRAAHLHRAFLPYAAVAQEILVRRRMADHDLSAERQAMNRLHEHT
                     VQLVLVEIEALRDAARRAASSYASLIADQQNVVINRLTIVSMIFLPLSFLTGFFGMNFA
                     FLTNRLTSEDSFLEFGVGLQVGAVIVALYYVLYRTHWRQLRDSRARDAAGDDQP"
     gene            complement(5872..7002)
                     /db_xref="GeneID:41539096"
                     /gene="alc"
                     /locus_tag="SAVERM_RS10505"
                     /old_locus_tag="SAV_1995"
                     /old_locus_tag="SAVERM_1995"
     CDS             complement(5872..7002)
                     /EC_number="3.5.3.4"
                     /GO_function="GO:0004037 - allantoicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539096"
                     /gene="alc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972679.1"
                     /locus_tag="SAVERM_RS10505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1995"
                     /old_locus_tag="SAVERM_1995"
                     /product="allantoicase"
                     /protein_id="WP_010983435.1"
                     /transl_table=11
                     /translation="MTAQHPSPSARFTGDANPYGGGDPYADYRTADFPFTQYANLADRQ
                     LGAGVIAANDEFFAQRENLLVAGRAEFDPEHFGHKGKIMDGWETRRRRGASAAHPWPTA
                     EDHDWALVRLGAPGVVRGVVVDTAHFRGNYPQAVSVEGASVPGSPSPEELLAGDVKWMT
                     LVPRTAVGGHAANGFEVSVEQRFTHLRVNQHPDGGIARLRVYGEAVPDPVWLAALGTFD
                     VVALENGGRVEDASNLFYSPATNTIQPGRSRQMDDGWETRRRRDHGNDWIRYQLVARSE
                     IRAIEIDTAYLKGNSAGWAAVSVKDGESGEWTEILPRTRLQPDTNHRFTLAAPVAGTHA
                     RVDIFPDGGISRLRLFGSLTEEGAARLTARYQELGG"
     gene            complement(7072..8409)
                     /db_xref="GeneID:41539097"
                     /gene="allB"
                     /locus_tag="SAVERM_RS10510"
                     /old_locus_tag="SAV_1996"
                     /old_locus_tag="SAVERM_1996"
     CDS             complement(7072..8409)
                     /EC_number="3.5.2.5"
                     /GO_function="GO:0004038 - allantoinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0050897 - cobalt ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539097"
                     /gene="allB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071203.1"
                     /locus_tag="SAVERM_RS10510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1996"
                     /old_locus_tag="SAVERM_1996"
                     /product="allantoinase AllB"
                     /protein_id="WP_010983436.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.8e-23, bitscore:
                     81.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDVELVLRSTRVITPEGTRPAAVAVAAGKITAVLPHDAEVPAGA
                     RLEDLGDDVLLPGLVDTHVHVNDPGRTHWEGFWTATRAAAAGGITTLVDMPLNSLPPTT
                     TVGNLRTKRDVAADKAHIDVGFWGGALPDNVKDLRPLHDAGVFGFKAFLSPSGVDEFPE
                     LDQERLARSMAEIAGFGGLLIVHAEDPHHLAAAPQRGGPRYTDFLASRPRDAEDTAIAN
                     LLAQAKRLNARVHVLHLSSSDALPLIAGAKAEGVRVTVETCPHYLTLTAEEVPDGASEF
                     KCCPPIREAANQDLLWQALADGTIDCVVTDHSPSTADLKTDDFATAWGGISGLQLSLPA
                     IWTEARRRGHSLEDVVRWMSARTARLVGLAQKGAIEAGRDADFAVLAPDETFTVDPAAL
                     QHRNRVTAYAGKTLSGVVKSTWLRGERIMADGEFTEPKGRLLSREP"
     misc_feature    complement(8432..8449)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     gene            8660..9463
                     /db_xref="GeneID:41539098"
                     /locus_tag="SAVERM_RS10515"
                     /old_locus_tag="SAV_1997"
                     /old_locus_tag="SAVERM_1997"
     CDS             8660..9463
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539098"
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642453.1"
                     /locus_tag="SAVERM_RS10515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1997"
                     /old_locus_tag="SAVERM_1997"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_010983437.1"
                     /transl_table=11
                     /translation="MPTSSASTTDSAKSPAPSGGVQSLERAFDLLERMADAGGEVGLSE
                     LSASSGLPLPTIHRLMRTLVACGYVRQQPNRRYALGPRLIRLGESASRLLGTWARPYLA
                     RLVEETGETANMALLDGDEIVYVAQVPSKHSMRMFTEVGRRVLPHSTGVGKALLANTPA
                     NEVRALLARTGMPAATEKTITTPDGFLAALEEVRRLGYAIDDNEQEIGVRCLAVSVPDS
                     PTAAAISISGPAGRVTEEATEKIVPVLQQVAAELSEALATSGPTA"
     gene            complement(9792..10082)
                     /db_xref="GeneID:41539099"
                     /locus_tag="SAVERM_RS10520"
     CDS             complement(9792..10082)
                     /codon_start=1
                     /db_xref="GeneID:41539099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482211.1"
                     /locus_tag="SAVERM_RS10520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5955 family protein"
                     /protein_id="WP_248844750.1"
                     /transl_table=11
                     /translation="MTGSDEDPRVAGLRTAVSRLRRELAAHPVEFPDRGIAEDELAALA
                     AMAVGGVPEIPRLRRSLLLIAGAIGSVSALARGLADVRGAVELFGEPPRRG"
     misc_feature    complement(9909..9911)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10316..10915
                     /db_xref="GeneID:41539100"
                     /locus_tag="SAVERM_RS10525"
                     /old_locus_tag="SAV_1999"
                     /old_locus_tag="SAVERM_1999"
     CDS             10316..10915
                     /codon_start=1
                     /db_xref="GeneID:41539100"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071199.1"
                     /locus_tag="SAVERM_RS10525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1999"
                     /old_locus_tag="SAVERM_1999"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_010983439.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.6e-34, bitscore:
                     118.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTENEDLVAGLLLAAGGGRRLGGRPKALLEHRGRPLVEHVAGVLR
                     AAGSTRVYVVLGAQAAAVRERAVLPGCILVDNPDWELGMGTSLRAGLEAMHGTGVRAAL
                     VSLVDQPGIGPAAVARVRAAYTSPSTLASAAYDGVRGHPVLFGAAHWAAVAASATGDRG
                     ARAYLKAHESAITLVECGDVAEAYDIDTVADLVHLE"
     gene            11137..12762
                     /db_xref="GeneID:41539101"
                     /gene="aceB"
                     /locus_tag="SAVERM_RS10530"
                     /old_locus_tag="SAV_2000"
                     /old_locus_tag="SAVERM_2000"
     CDS             11137..12762
                     /EC_number="2.3.3.9"
                     /GO_function="GO:0004474 - malate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539101"
                     /gene="aceB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133434.1"
                     /locus_tag="SAVERM_RS10530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2000"
                     /old_locus_tag="SAVERM_2000"
                     /product="malate synthase A"
                     /protein_id="WP_010983440.1"
                     /transl_table=11
                     /translation="MSAPAPSPLALVDAEPLPRQEEVLTDAALAFVAELHRLFTPRRDE
                     LLARRAQRRAEIARTSTLDFLPETAAVRADESWKVAPAPAALNDRRVEITGPTDRKMTI
                     NALNSGARVWLADFEDASAPTWENVVVGQLNLTDAYTRNIDFTDPKSGKSYALKANEEL
                     ATVVMRPRGWHLNERHLVDSQGRPVPGALVDFGLYFFHNARRLLDLGKGPYFYLPKTES
                     HLEARLWNDVFVFAQDYVGIPQGTVRATVLIETITAAYEMEEILYELRDHASGLNAGRW
                     DYLFSIVKNFRDGGAKFVLPDRNAVTMTAPFMRAYTELLVRTCHKRGAHAIGGMAAFIP
                     SRRDEEVNKVAFEKVKADKDREAGDGFDGSWVAHPDLVPIAMASFDAVLGDKPNQKDRL
                     REDVSVAPGDLIAIDSLEAKPTYNGLVNAVQVGIRYIEAWLRGLGAVAIFNLMEDAATA
                     EISRSQIWQWINAGVEFENGEKATPELARKVAAEELANLRAELGEEAFAAGNWQQAHDL
                     LLKVALDEDYADFLTLPAYEQLAG"
     gene            complement(12767..13048)
                     /db_xref="GeneID:41539102"
                     /locus_tag="SAVERM_RS10535"
                     /old_locus_tag="SAV_2001"
                     /old_locus_tag="SAVERM_2001"
     CDS             complement(12767..13048)
                     /codon_start=1
                     /db_xref="GeneID:41539102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385728.1"
                     /locus_tag="SAVERM_RS10535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2001"
                     /old_locus_tag="SAVERM_2001"
                     /product="SelT/SelW/SelH family protein"
                     /protein_id="WP_037647298.1"
                     /transl_table=11
                     /translation="MTTPHTHRVQIEYCTQCRWLPRAAWLAQELLTTFETELTELALKP
                     GTGGVFVVRVDDEVVWDRREQGFPEPTAVKRLVRDRVAPEKSLGHSER"
     gene            complement(13045..13959)
                     /db_xref="GeneID:41539103"
                     /locus_tag="SAVERM_RS10540"
                     /old_locus_tag="SAV_2002"
                     /old_locus_tag="SAVERM_2002"
     CDS             complement(13045..13959)
                     /codon_start=1
                     /db_xref="GeneID:41539103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823965.1"
                     /locus_tag="SAVERM_RS10540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2002"
                     /old_locus_tag="SAVERM_2002"
                     /product="HipA family kinase"
                     /protein_id="WP_010983442.1"
                     /transl_table=11
                     /translation="MLREVTAVRYVTPLRAGGSVPGVVEADDLGTYVVKFTASAQGRKA
                     LVAEVIVGELARRLGLRFPELVLVHFDPTVAEHEPHQEVQDLLHASAGVNLGMDYLPGA
                     EDFTPEIAKTFDVDPLEAGKVIWLDALTVNVDRTVHSSNLMIWPTFGIAPPRLWLIDHG
                     AALVFHHRWDASSPEKAYDFRSHALGGYAPDTRAADAELAPRVTEELLREVLAEVPDAW
                     LADEPGFDTPDDVRAAYVGYLAARVRASGTWLPTDFPTREQLTAEDAHRAAKTRAGRPN
                     WLKRVPDLHGKPAAEQDWSVHLG"
     gene            complement(14001..15509)
                     /db_xref="GeneID:41539104"
                     /locus_tag="SAVERM_RS10545"
                     /old_locus_tag="SAV_2003"
                     /old_locus_tag="SAVERM_2003"
     CDS             complement(14001..15509)
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539104"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039025.1"
                     /locus_tag="SAVERM_RS10545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2003"
                     /old_locus_tag="SAVERM_2003"
                     /product="IucA/IucC family protein"
                     /protein_id="WP_037647295.1"
                     /sec_met_domain="IucA_IucC (E-value: 2.7e-47, bitscore:
                     160.2, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRVDPMIPMSPGDDVGPAADAYADAPLLNCLLREMGEPAGDQGV
                     YRLRSGGRLLRVRGDRRPRDPEVYAGGAWHRLTHAELVKLVAEELRRGTGLSNSELPGE
                     MVDSRDAVAALLGARARATPPDDPYLRSEQSLITGHPHHPAPKARGGGPVTGWLPYAPE
                     AYARFPLVLLGVRADTVVEEGDTTALDALAEAPPGYRLLPAHPWQLDLVGARPEIRDAF
                     ADGRLVRLGRTGCAVWPTAAVRTLYAPEADLFLKFSLDVRITNDVRRLWRHDLLKLRRT
                     DEAAANAFAAARGPAAWLSDRGYRTAGFAFEELAVLVRDGLAPHLLPGTTPLLAAALVE
                     GFDGNPLDRLDDPRAWWAAYLRQVVPPVLDAFARHGVVLEAHLQNTLVAVDADGMPVQA
                     LFRDAEGVKLLPDVSRAAGWERLVYCLVVNHLAELAALLAERRPGTDPWPAVRRELARH
                     DLPEVGELLASPTLPGKTNLLLRWTGADGADARYLPLPNPLARA"
     misc_feature    complement(15513..15526)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            15604..17112
                     /db_xref="GeneID:41539105"
                     /locus_tag="SAVERM_RS10550"
                     /old_locus_tag="SAV_2004"
                     /old_locus_tag="SAVERM_2004"
     CDS             15604..17112
                     /codon_start=1
                     /db_xref="GeneID:41539105"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996683.1"
                     /locus_tag="SAVERM_RS10550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2004"
                     /old_locus_tag="SAVERM_2004"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_010983444.1"
                     /sec_met_domain="IucA_IucC (E-value: 6.9e-33, bitscore:
                     113.0, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRPATAESELAAELDAVRPGLSAPYAAALPGARAAVLTRLWRAL
                     AHEPLPWIAHREPEPGGLTLRLADGRRLHGPPSDPYATAPYVTGVRLDETSYAHPARLV
                     SALGVPHGPALAAELDHSVASLALSRAGQPRVDPKSPTTSWEWEQRVVDGHPFHPNCRS
                     RPGFSAAEQLAYGPEHRPVVRLGLVAVEECLVRGEWPKWLRDGERVLIPVHPWQTAHVL
                     DAPVEDGPAAHPLMSLRTLALRDGGPDVKTALSARLTSSVRDISVYSIETSATVSEFAE
                     AFAARTDGLLHITRTLGAATAGRPELAAVVRESPDTYADAEAAERVVPVASLTGTGLPG
                     SPAWLAEFTRLTLTVGLRLLDLGVALEAHGQNLLVVLSATGAPLRLVYRDLADIRVSPA
                     RLARHGVPLPDLGGRLVTDDETTLRRKLFGSLVAGALAATAGSGPALREALAAAARDLP
                     RTPDLTALLEEPLPAKALTLMRLSPDRPGDSWAQLPNPLVTRAF"
     gene            17167..18429
                     /db_xref="GeneID:41539106"
                     /locus_tag="SAVERM_RS10555"
                     /old_locus_tag="SAV_2005"
                     /old_locus_tag="SAVERM_2005"
     CDS             17167..18429
                     /codon_start=1
                     /db_xref="GeneID:41539106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385720.1"
                     /locus_tag="SAVERM_RS10555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2005"
                     /old_locus_tag="SAVERM_2005"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_010983445.1"
                     /transl_table=11
                     /translation="MITRQRLAVGLCALLAALTAGFAFPAGAVADETTADAPKVDLVLD
                     VSGSMRARDIDGGSRMAAAKQAFNEVLDATPEEVRLGIRTLGANYPGDDRKTGCKDTAQ
                     LYPVSTLDRTEAKTAVATLSPTGWTPIGPALLKAADDLDGGTGSHRIVLITDGEDTCAP
                     LDPCEVAREIAAKGVGLTIDTLGLVPNSKLSKQLSCIAEATGGTYTSVEHKEDLTDKVN
                     QLVDRAADKVVTPVAVDGAADCAKAPTLKSGLFTDRAEFAQHRWYRVDVKPGQELRASV
                     SLSADRQVNPDYGVLLRAVTVHNREIVRGEAAGTGRTDVVSTGLRYPKAESDDEDATAE
                     TVCLQVSHSFSPAAGVKTTPGLPLELTVDVVDGPDQAGDVASFGLGRGWWLLGALVLTG
                     FLAGLLWGWLSRWRFAVWRTN"
     gene            18429..19274
                     /db_xref="GeneID:41539107"
                     /locus_tag="SAVERM_RS10560"
                     /old_locus_tag="SAV_2006"
                     /old_locus_tag="SAVERM_2006"
     CDS             18429..19274
                     /codon_start=1
                     /db_xref="GeneID:41539107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993982.1"
                     /locus_tag="SAVERM_RS10560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2006"
                     /old_locus_tag="SAVERM_2006"
                     /product="hypothetical protein"
                     /protein_id="WP_010983446.1"
                     /transl_table=11
                     /translation="MRISRVLKSGVRNSGVLVAAGLLLGAAVAPAVADSSPSASPSGDS
                     AAPTSAGTSFRTATEIAQGQRATAGGSAGDYLYWSFPADTGLRPTVKATVKFPQSAERG
                     ASQTWQLDVYDGLRRRQACQYGAQTRTAAQDATSVDLSCTLRTVRAWSEPWADDPLPGT
                     YYVRLTLVDVATGDLGLPVSAEVQVDSKDIGGSAAVDGSLSQPLVPGIATASDTSDEGS
                     DSAKASLFSLEPDDGWASGWWTDRWVWTAIGGILAALAGIGGYALTKGSGRPRQVPPGA
                     "
     gene            complement(19649..20287)
                     /db_xref="GeneID:41539108"
                     /locus_tag="SAVERM_RS10565"
                     /old_locus_tag="SAV_2007"
                     /old_locus_tag="SAVERM_2007"
     CDS             complement(19649..20287)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539108"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039037.1"
                     /locus_tag="SAVERM_RS10565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2007"
                     /old_locus_tag="SAVERM_2007"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_037647292.1"
                     /transl_table=11
                     /translation="MPPRRSYDQYCSAARALDAVGDRWTLLIVRELLGGPRRYTDLHAD
                     LPGVSTDVLASRLKDMERDGLTTRRRLPPPGAVYVYELTGRGRELLPVLQALGSWGAPA
                     LAERRATDAVRAHWFALPLLRSLEGDGLAVGLLEIRLEEGRFHLHLGAAEGPAYGEGPA
                     PEEPDARLVIDADTCMALSRETLTLHQAVREGRAEITGESALAKLLRGD"
     gene            20373..21581
                     /db_xref="GeneID:41539109"
                     /locus_tag="SAVERM_RS10570"
                     /old_locus_tag="SAV_2008"
                     /old_locus_tag="SAVERM_2008"
     CDS             20373..21581
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (33-393). E-value:
                     1.6e-53. Score: 174.1. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS10570_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GeneID:41539109"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007390030.1"
                     /locus_tag="SAVERM_RS10570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2008"
                     /old_locus_tag="SAVERM_2008"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_010983448.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2e-51, bitscore:
                     174.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.5e-06,
                     bitscore: 25.8, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFRQSSKLSEVCYEIRGPVIEHANALEEAGHSVLRLNTGNPALF
                     GFEAPEEILQDMIRMLPRAHGYTDSRGVLSARRAVAQRYQDRGLEVDVDDVFLGNGVSE
                     LVSMAVQALIEDGDEVLIPAPDFPLWTAVTTLAGGKAVHYLCDEQADWYPDLADMAAKI
                     TDRTRAVVIINPNNPTGAVYPKEIVEGILDLARRHGLMVFADEIYDQILYDDAVHHSAA
                     ALAPDLVVLTFCGLSKTYRVAGFRSGWLVVTGPKQHARSYLEGLTMLASMRLCANAPAQ
                     YAIQAALGGRQSIQELTAPGGRLYEQRDRAWQKLNEIPGVSCVKPKGALYAFPRIDPTV
                     HKIHDDEKFVLDLLLREKIQVVQGTGFNWPRPDHFRILTLPHADDLDAAISRIGRFLSG
                     YRQ"
     aSDomain        20472..21551
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS10570_Aminotran_1_2.1"
                     /evalue="1.60E-53"
                     /label="SAVERM_RS10570_Aminotran_1_2.1"
                     /locus_tag="SAVERM_RS10570"
                     /protein_end="393"
                     /protein_start="33"
                     /score="174.1"
                     /tool="antismash"
                     /translation="VLRLNTGNPALFGFEAPEEILQDMIRMLPRAHGYTDSRGVLSARR
                     AVAQRYQDRGLEVDVDDVFLGNGVSELVSMAVQALIEDGDEVLIPAPDFPLWTAVTTLA
                     GGKAVHYLCDEQADWYPDLADMAAKITDRTRAVVIINPNNPTGAVYPKEIVEGILDLAR
                     RHGLMVFADEIYDQILYDDAVHHSAAALAPDLVVLTFCGLSKTYRVAGFRSGWLVVTGP
                     KQHARSYLEGLTMLASMRLCANAPAQYAIQAALGGRQSIQELTAPGGRLYEQRDRAWQK
                     LNEIPGVSCVKPKGALYAFPRIDPTVHKIHDDEKFVLDLLLREKIQVVQGTGFNWPRPD
                     HFRILTLPHADDLDAAISRI"
     gene            21693..22292
                     /db_xref="GeneID:41539110"
                     /locus_tag="SAVERM_RS10575"
                     /old_locus_tag="SAV_2009"
                     /old_locus_tag="SAVERM_2009"
     CDS             21693..22292
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /db_xref="GeneID:41539110"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482179.1"
                     /locus_tag="SAVERM_RS10575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2009"
                     /old_locus_tag="SAVERM_2009"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_010983449.1"
                     /transl_table=11
                     /translation="MGDLLLVRHGETEWSVSGRHTGSTDIPLTENGREQARRLAPLIAS
                     HHVGAAFVSPMRRARETARLAGLDGARVDADLSEWDYGGYEGVTTVEIHRTRPDWFLFT
                     DGVEPGPPEHPGESPEEVGARAERMLAKVDAALADTEGSVVVVSHGHFLRVLAARRLGL
                     PASGGALFQLATGTVSRLSTEHRRHVVASWNVRPSS"
     misc_feature    21723..21738
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            22352..22975
                     /db_xref="GeneID:41539111"
                     /locus_tag="SAVERM_RS10580"
     CDS             22352..22975
                     /codon_start=1
                     /db_xref="GeneID:41539111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494542.1"
                     /locus_tag="SAVERM_RS10580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_037647287.1"
                     /transl_table=11
                     /translation="MTRPPTAAQRRVIEAADPVTGRLKGTEAQLAALVKRGLAFRHPRP
                     PHDHFLTPAGHRIREAPEPVVETPAPAEAGSGVFAARIGGEEGEAGPSRLREVHSAWQG
                     LLELRRMTSPDGAVDRPCGWERAHLVQAAALALEAAGHRPAGTDGGGYRVRATPQPEAV
                     AVQEPDPEALRACAATLEKAGWQVGEHAEPRTGARYVLASPRRV"
     misc_feature    complement(22388..22402)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            23117..23539
                     /db_xref="GeneID:41539112"
                     /locus_tag="SAVERM_RS10585"
                     /old_locus_tag="SAV_2011"
                     /old_locus_tag="SAVERM_2011"
     CDS             23117..23539
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539112"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482177.1"
                     /locus_tag="SAVERM_RS10585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2011"
                     /old_locus_tag="SAVERM_2011"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_010983451.1"
                     /sec_met_domain="4HBT_2 (E-value: 2e-24, bitscore: 85.2,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEPFSVAVTVRGYETDVQGHLNQSVYLQYAEHARWSLLHAAGIS
                     QTELTGKGVGPVTLETTIRYKRELRAGDEVEVTCGFVWGEGKSFRVEQTIRKTDGTVSA
                     ELTAVGGLLDLKERRLVADPREYFRALAADPGLFDL"
     gene            complement(23592..23993)
                     /db_xref="GeneID:41539113"
                     /locus_tag="SAVERM_RS10590"
                     /old_locus_tag="SAV_2012"
                     /old_locus_tag="SAVERM_2012"
     CDS             complement(23592..23993)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539113"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656864.1"
                     /locus_tag="SAVERM_RS10590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2012"
                     /old_locus_tag="SAVERM_2012"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_010983452.1"
                     /transl_table=11
                     /translation="MSQGNTAVTAQVVNAHACPVREVLDRVAGKWSVQIIVAAAHGPIR
                     FTELERSIEGISRRMLTLTLRNLERDGLVTRTVHSTVPPKVEYELTPVAGELHATLLSL
                     TDWAERHRVTVAQSRAAYDARHRPELLDG"
     gene            24095..25555
                     /db_xref="GeneID:41539114"
                     /locus_tag="SAVERM_RS10595"
                     /old_locus_tag="SAV_2013"
                     /old_locus_tag="SAVERM_2013"
     CDS             24095..25555
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539114"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656865.1"
                     /locus_tag="SAVERM_RS10595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2013"
                     /old_locus_tag="SAVERM_2013"
                     /product="MFS transporter"
                     /protein_id="WP_010983453.1"
                     /transl_table=11
                     /translation="MSFLIESRTRQRQRTPSRWASLVVLCAGTLMTVLDGNVVTVAMPA
                     IQGDLGFSGPGLAWVVNAYLIPFGGLLLLVGRLGDLVGGKRMFTAGLAVFTVASVLCGV
                     ATSQATLVAARALQGIGGAMTSAVVLGMLVALFPEPREQARAIAVFSAVGAAGGALGTF
                     LGGALTQALNWHWIFLINLPIGVLAWLAALRFLAPERGAGLGRGADYPGAALVTGALML
                     TVYAIVGAGDRGLAGTLVLAAVSLALFSAFTVRQARAPRPLLRLRLFRSRVLTGANAVQ
                     VLMIGGMFGFQYIGALYLQRVLGYGELLTGTAFLPAPIAIGVLMLGLSARTIARFGPYR
                     VLLSGLVLISAGMALLSRAPVDGTYLADVLPPLLLLAAGFAAAMPAVTGLAMSGARAED
                     AGLASGLFNTTQVVGGSLGLAVLTTLAASRTDHLRHGGADLVAATASGYRLAFMVATGI
                     AVAALVLAAGVLRTERATSGQPPANTPR"
     gene            25751..27937
                     /db_xref="GeneID:41539115"
                     /locus_tag="SAVERM_RS10600"
                     /old_locus_tag="SAV_2014"
                     /old_locus_tag="SAVERM_2014"
     CDS             25751..27937
                     /codon_start=1
                     /db_xref="GeneID:41539115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482174.1"
                     /locus_tag="SAVERM_RS10600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2014"
                     /old_locus_tag="SAVERM_2014"
                     /product="alpha-N-acetylglucosaminidase"
                     /protein_id="WP_010983454.1"
                     /transl_table=11
                     /translation="MPLARRVLLTALAAGSAGAAVACDPASADGAPAAGSAATAARRLL
                     PRHWRQLTFRTAGGRDTFQVSGRTGRVTVTGGTPATQLTGLNWYLRNIADADINWAGRQ
                     LRLPRALPGLAGTVTRRANVPHRFALNDTNDGYTGPYHDWTYWERELDVLALHGYNEVL
                     VQTGADALHHRVFQEFGYTDEELRKWIPGPAHQPWWLLQNLSAFPDPVSQQLLDARAAL
                     GRRIANRLRELGMTPVFPGYFGTVPPGFADRNAGAHTVPQGTWMGFARPDWLDPRTEHF
                     TRVAAAFYRIQDEMFGGASTRYKMDLLHEGGSPGDVPVGDAAKGVERALRAAHPGAVWV
                     ILGWQHNPPRAIVDAVDKDRMLVVDGLCDRFPKVTDREADWHGTPYAFGSIWNFGGHTT
                     LGANTPDWASLYERWRTRPGSTLRGVALLPEAADNNPAAFALFSELAWREGDLDLRAWF
                     ARWARSRYGGRDPHAEAAWDILRRTAYGTTRADSWSEGADGLFGARPSLAATKAASWSP
                     KRLRYRPEEFEPALGELLKVRPGLRGSSAYRRDLLDVARQALSNRSRVLLPQIRTAYEA
                     KDTARFDRLTGVWLALMDLLEALLATDSRHLLGRWVADARAWGASAAERDRLAYDALSL
                     LTVWGTRAGADAGLRDYANREWAGLVGGLYRLRWSTYFAELRSASREGRTPKKTDWFAL
                     EDRWTRNPGGLATRPTGDTYQAAVRVHERLTAER"
     gene            28065..28880
                     /db_xref="GeneID:41539116"
                     /locus_tag="SAVERM_RS10605"
                     /old_locus_tag="SAV_2015"
                     /old_locus_tag="SAVERM_2015"
     CDS             28065..28880
                     /codon_start=1
                     /db_xref="GeneID:41539116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006377102.1"
                     /locus_tag="SAVERM_RS10605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2015"
                     /old_locus_tag="SAVERM_2015"
                     /product="chitosanase"
                     /protein_id="WP_010983455.1"
                     /transl_table=11
                     /translation="MHSPHIRTSRRTLLALIGASLVAGPLVANQSATAAPVGLDDPAKK
                     EIAMKLVSSAENSSLDWKAQYKYIEDIGDGRGYTAGIIGFCSGTGDMLDLVELYTQRKP
                     GNVLATYLPALRNVNGGDSHQGLDPGFPGDWRRAAQDSAFQQAQNDERDRVYFDPAVRQ
                     GKADGIGVLGQFTYYDAIVMHGDGGDSTSFSSIRGRALAKAEPPAQGGNEVTYLNAFLD
                     ARVWAMRQEEAHSDTSRVDTAQRVFLTKGNLNLDPPLDWKVYGDSYHIG"
     gene            complement(28987..30360)
                     /db_xref="GeneID:41539117"
                     /locus_tag="SAVERM_RS10610"
                     /old_locus_tag="SAV_2016"
                     /old_locus_tag="SAVERM_2016"
     CDS             complement(28987..30360)
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41539117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847774.1"
                     /locus_tag="SAVERM_RS10610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_2016"
                     /old_locus_tag="SAVERM_2016"
                     /product="nucleobase:cation symporter-2 family protein"
                     /protein_id="WP_042492921.1"
                     /transl_table=11
                     /translation="MTTSGLQHVAAMYAGVVAPPLIVGAAAGLSGTELTFLTGACLFTA
                     GLATFLQTLGFWKIGARLPFVNGVTFAGVAPMTAIVASTKDRSDALPIIFGAVIVAGAL
                     GFVAAPFFSKAVRFFPPVVTGTVITLIGVSLLPVAFGWAQGPDPTADSYGSTTYLGLAA
                     ATLVIVLLLRRFTHGFVKQIAVLLGLVIGTLLAIPLGVTDFGPVAGADLIGFPTPFHFG
                     APRFQLAAILSLSVVMVVSMTESTADMLALGEIVGRPADERTIAAGLRADTLGSALSPL
                     FNGFMCSAFAQNIGLVAMTRIRSRYVVATGGGFLVLMGLCPVAASLIAVVPRPVLGGAG
                     VVLFGSVAASGIQTLVRAGLEKDNNVLIVAVSLAVGIIPITAPEFYHAFPQTAKIVLDS
                     GISTGCVAAVVLNLLFNHLGRRQGDDEVTAPMEPGEEIAGQRGGAGSPAAGPSAVTAH"
     misc_feature    30351..30365
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
ORIGIN
        1 gccgcgggca accaccgcaa gaacctgacg ctttcgctgg agacgagcct gcgcaggctg
       61 ggcaccgact acatcgacgt ctactgggtg cacatctggg accggaacac cccgatcgag
      121 gagaccgtac gggccctcga cgacgccgtg cggtccggga aggtgctgta cgtgggcata
      181 tcggatgtcc cggcctgggt ggtgtcgcgg gccaacacgc tcgcggaatg gcgggggtgg
      241 acgccgttct cggcgctcca ggtcccctac agcctgctca accgcgacat cgagcgcgaa
      301 ctgctgccga tggccgaggc gttcggcatg tcggtggcgg cctggagccc gttgcagaac
      361 ggcatcctgt ccggcaagta cacccgcccc ggcggcctgg agccgggcac ggcggcccgg
      421 ttgccggcgg aggcgatcgg tgaccgcgag cgggccgagg ccgaggccgt gcagtccgcg
      481 gccgacgaac tcggcgtctc ctgcgcgcag gtggccatcg cctggacgat ggcccactcc
      541 cccgccgtgc acccgatcct cggcgcccgt cgcgtggagc agctcgtgga aaacctgggc
      601 gcggccgaac tgaccctgcc gacggaggtg ttggccgcgc tcgagagtgc gacggacttc
      661 cgcgcgggct tcccggcgga cttcatcgac gacacgtcgg catgggtgta cggcacggcg
      721 gggcatcggg tggtggggcg cgccgggtga ggcccccgga ggggcgggcg ctcggcctcg
      781 ggctcccgca cggccgaact cgggctcccg cacgacgccc cgggccgggc tgttcggcct
      841 cccgccgccc cgctaccggg gatccggccc cggccccggc cacggcagcc aagcccgcag
      901 cccgaacccg ccgtcgccct ccgcaccgtg gtcgagtcgg ccgcccgcca gggtcgcgcg
      961 ttccatgagg ccgatcaggc cctgaccgga gccggggaca tggggtacgt cgcccggcgg
     1021 cgcgggattg cgcacggaga cggtgaggcc gtcgcccggg gcgcccgcca cggtcaccgt
     1081 gacctcggcg ccgggcgcgt gcttgcgcgc gttcgtcagg ccctcctgga cgatgcggta
     1141 cgcggtgcgg ccgatggagg cggggaccgc ggcgggggcg gtcacccggt ggtcgaggac
     1201 gatcttcata ccggcctcgc gggactcggc gaccagcccg tcgagggcgg cgagcgtcgg
     1261 ttgcgggcgg cccgcgtcgt cggcgtcgcc cgcccgcagc acgccgatga tctcccgcag
     1321 gtcctgcaac gcctcgtgcg cgctctcccg gatcaccccg gccgcccgcg cgatctcctc
     1381 ccggggcgcg tcggggcgga actccagcgc gccggcgtgc acgctcagca gcgtcagccg
     1441 gtgggcgagc acgtcgtgca tctcgcgcgc gatggcctcc ctggccagcc gctgcgcctg
     1501 ctcggcccgc agctccgcct ccgtctcggc gcgccgcgcc cggtcccgca gactcagcac
     1561 gagctgccgc ttggatcgta cgaacatccc ccagccgacc accgtcacgg tcagcagccc
     1621 ggcgacggcc acggcggcga catagggcag atcggggtcc gggcgcagcc agtagacgcc
     1681 cgggagcagc gcgagctgga tgccgccgac ccacgcgacg taccggaagg gcaggtgcac
     1741 ggcgagggtg aagagggcga tcaggcccgc gccgcccgcg gtgttcgaga tcagcccgac
     1801 cggcatcatc gccacggcga gcccgagcgg ccggcggcgc cgcagccaca ccgccgcaca
     1861 ggccgacgcg ccgagccatt ggtcggcgac ggccaggccg tgcgggatgt cgtgctcccg
     1921 ggtcaccgcc tccgcggcgg cgatcccgat gaccacggcc agcaggacgc agccgaggtc
     1981 gacgatccag tcccgcacgg tacgccgcgg atgccggcca cgctccgcgc cgccggcgtc
     2041 cagcgctgcg atcacggcgg acggcaggaa ccaccgctgc cggggcagcc cgtacgacag
     2101 cggcacggcc ggctccggca gccccggcgg ccgcgggccg gaccgagccg gcaccatccg
     2161 ctcgaacacg gcccggtatg tcgacgcccc cggggaaggc gccggcttgt cactgctcac
     2221 ggtcgacaaa tttacgcagg gacggccgcc ggcacctccc cgccgacgcg accgacgacc
     2281 aaagtcgtcc actcgaagac tttcggcgcg gctgcctgcg gggaggccgc ggcttcggac
     2341 ggacaggcct cgccccgcgg ccggtgagcg tggggggtcc gcggggcgag ggtcttcctg
     2401 tgcaggcctc cggcctggtc gcgccgttcc tcgagagccg gacgtcggct cagcacatcg
     2461 gctcagcacg tccactcagc acatcggctc agcgctcgac gtgtgactca gcagtcgaag
     2521 tcgatcaggt cgaacgtgac gtagtggtcc gaggtgtagt agtcctcctg ggtctgcttg
     2581 cccgtgacga tgcggcgggc accgcgcgtc gaggagccgg gcgtcttcac ggtgtactcg
     2641 tggtagtagc cgctggactg cgtgggcagg acgccttccc ggttctggaa gacggccccg
     2701 tcctgcgagt acgggaaggg gccgttcgac tcgatcagat cgagcgtgtc gtacgcctgg
     2761 gacggcaggt cgctgtagca gatgctgccg accgaggcgg ccgtggcatc cgcggtcgtc
     2821 gcggagaccg tgccgcccac gagcagggcg gacaggagcg cggctgcggc gctgatacga
     2881 gtgattcgtg gggggaatct catggctcta gaatgacgcg cgtagaccat gacatgtcaa
     2941 tgtcaaggca actgatttct cccgccgagt ccgttgaatt ttccgggagt taacctgccg
     3001 cccggcgccc ccacgcggtc cccgcgagga cgagaacgcc ccccatcagc cccaacgcgc
     3061 cgagacgttc gccgccgagg gtgatccccg cggcggcggc ccacagcggc tcggtgccga
     3121 gcagcaggct gacccgggac ggcgaggtcc ggcgtacggc ccacatctgt acgcagaacg
     3181 cgaagagcgt gcagaacgcc gcgaggaaga gcagcccgcc ccactcccgc gccccgaagc
     3241 ccgcggccgt gccccacacg gtcgcgtcgg tgccggtcga gagcaccgcg aacacggcga
     3301 ccgcggcacc cagttggacc gtggtcaggg gcagcgcgtc ggcgccctga acggacttga
     3361 cgcgggacat ggcgagcacg tggacggtgc gggcgagggc cgcgagcagc atcagcagat
     3421 cgccgagcga ggggcgggtg aacccgccgc cctgggtgag cagcacgacg ccgagcacgg
     3481 agaccccggc cgcggcgagg aaggcccgcg ggggccgcgc ccgggtcacg gccgcctcgg
     3541 cgagcggcgt gaagatcatg gtgaggctga tgatgaggcc cgcgttggtc gccgaggtgt
     3601 ggacgacgcc gtacgtctcc aggaggaaga tcccgctcag gatcagcccc agcagcgccg
     3661 ccccgcgcca ctgcgcggcg ctcagcgcgc gcagcgaacg ccgtccggcg atcaccagca
     3721 cgggcaggac gacgccgaag cgcagcacca ggacggcgat caccgtccgc gccgtggtga
     3781 tgtccttggc cgcgagatag ctggctcccc acaccaccgc gacgagcagc acgggcaggt
     3841 cggtgagcca ggcacggcgg ggcgcgagcg cgccgggtac ggcgatcgac gacatgggag
     3901 cggtctccag cgggcggacg ggcgtggaga cgtcggcggc tctcacaggg aacgatcacc
     3961 gtaccggcga ggatgcgtga gggctacacg gtttcggcgg acgcttcggc agcggacgct
     4021 tcagtagctg ccgtacgtcg gacggcccgc ccgttcgtac gtgtggatcg ccacgcccgc
     4081 gcccgtggtg ctgccaaaga cgtgccggaa cgcggtgggg acggcgccct cggcgaacag
     4141 gcggcggccg gcccccagta cgaccgggaa ggtcagcagg tgcacggtgt cgatcagatc
     4201 gagcgcgagg agggaccggg cgagggcacc gctgccgtgg acctggagct cgcgggcggt
     4261 gcgctccttg agggcggcga cctccttggc gaggtcgccg cggatcacgg tcgtaccgga
     4321 ccaggcgggg tccgtgaggc tcgacgaggc gacgtacttc ggcagggagt tgagcttggc
     4381 ggcgatcggg tcggcggggt cggtgacctt cggccagtag ccggcgaaga tctcgtacgt
     4441 gcgcctgccg agcaggaagg cgtccacgcg ggcgaaggcg tcggtcacga accgtccgaa
     4501 gtcctcgtcc ccgtacggga cgctccagcc gccctgctcg aagccgtcgc tgcggtcctc
     4561 ctcgggtccg ccgggagctt ggtggacacc gtcgagggtg acaaaagcgg tgagggtgag
     4621 cttgcccatg acagctgcct tcttccttcg gtggggtccc cgtcctcagg acagacccca
     4681 ccggcacccg tgactcatcg gtcccccgga aaccggcgag gggcggggac acggcgctgt
     4741 gcgcggtcag ccgttcgcgg ggccttcggc ggtagtgtgc cgatggacgt tgcagtgccg
     4801 cacgacgcca tccacggtga ggggcgatga tcgtttcggt ggtgtcgatg ccggagggcg
     4861 tcgtcgctcg cacggggctg acacaggccc gggagcatct cgcgtcctcc cgtttcgtga
     4921 tcgtggacgt cgaccaggaa gaagaacccc cgctcgacga cgagccgctc tcccgtcggc
     4981 tcgggctgga tgacgcggcc tggaagtggc tcggcagacc ggacgagcac gtccgggtcg
     5041 agtaccacgc gggcacggcc gccggcgtcg tgccggtggt ctgcggcaac caggtcatcc
     5101 acatccacgt cctggccggc gatcggcact tcatcacgat tcatcagggg cccgtcgaac
     5161 tgatcgacac cttcatcggc cagttgccgc aggaccggcc ccccgacgcg gtgacgacgc
     5221 tgttcctgtt tctgcaaggg gtcctggaga cgtatcgccg ggccatcacg caggcccatc
     5281 tggaggtcga ggacctcgag gaagcgatgt tcgagcaacg gcagccggag caggtccgtc
     5341 ggctggccca gctgcgacag cgcgcggccc acctgcaccg cgcgttcctg ccctacgccg
     5401 cggtcgcgca ggagatcctc gtacgtcgca ggatggcgga tcacgacctc tcggcggaac
     5461 ggcaggcgat gaaccgcctg cacgagcaca ccgtgcagct ggtgctcgtg gagatcgagg
     5521 cgctgcggga cgcggcccgg cgagccgcga gcagctacgc gtcactcatc gccgatcagc
     5581 agaacgtcgt gatcaaccgg ctcaccatcg tctcgatgat cttcttgccg ctgtcgttcc
     5641 tgaccggatt cttcggcatg aacttcgcct tcctgaccaa ccggctcacg agcgaggact
     5701 ccttcctgga gttcggcgtg ggtcttcagg tgggtgcggt gatcgtcgcc ctgtactacg
     5761 tgctgtaccg cacccactgg cgtcagctgc gcgacagccg ggcccgcgac gccgccggcg
     5821 acgaccagcc ctgactccgc cccggcgggg cgccacgagg cagcacggcc ctcagccgcc
     5881 gagctcctgg tacctggccg tcaggcgcgc cgcgccctcc tccgtcaggg agccgaacag
     5941 gcgcaggcgg gagatgcctc cgtccgggaa gatgtccacg cgcgcgtggg tcccggccac
     6001 cggcgcggcc agggtgaagc ggtggttggt gtcgggctgc aggcgggtgc gcgggaggat
     6061 ctccgtccac tcgccgctct caccgtcctt caccgacacc gccgcccacc cggcgctgtt
     6121 gcccttcagg tacgccgtgt cgatctcgat cgcgcggatc tcggaccggg cgaccagctg
     6181 gtagcggatc cagtcgttgc cgtggtcgcg gcggcgccgc gtctcccagc cgtcgtccat
     6241 ctggcgggag cggcccggct ggatcgtgtt cgtggcgggt gagtagaaga ggttcgaggc
     6301 gtcctcgacc cggccgccgt tctcgagggc cacgacgtcg aaggtgccca gcgccgccag
     6361 ccacacgggg tccggcacgg cctcgccgta cacccgcaga cgggcgatgc cgccgtcggg
     6421 gtgctggttg acccgcagat gcgtgaagcg ctgctccacc gacacctcga agccgttcgc
     6481 cgcgtggccg ccgaccgccg tgcgcgggac gagcgtcatc cacttcacgt cgcccgcgag
     6541 gagttcctcc ggggacgggg acccgggtac cgaggcgccc tcgaccgaca ccgcctgcgg
     6601 gtagttgccc cggaagtggg ccgtgtcgac gacgacgccg cgtacgacgc cgggcgcgcc
     6661 gagacgtacg agcgcccagt cgtggtcctc ggccgtcggc cacgggtgtg cggccgaggc
     6721 gccgcgccgg cggcgggtct cccagccgtc catgatcttg cccttgtgcc cgaagtgttc
     6781 ggggtcgaac tcggcgcgtc cggccacgag gaggttctcg cgctgggcga agaactcgtc
     6841 gttggcggcg atgacaccgg cgccgagctg ccggtcggcg aggttggcgt actgggtgaa
     6901 ggggaagtcg gcggtgcggt agtccgcgta cgggtcaccg cctccgtagg ggttcgcgtc
     6961 gccggtgaag cgggccgaag gggatggatg ctgcgccgtc acggtgatca ggtctgcctc
     7021 tcgggagtcg gccactgcgg gtgcggagga ggattacgcg gggggggcgg actacggttc
     7081 cctgctgagg agccggccct tcggctccgt gaactcgccg tcagccatga tgcgttcgcc
     7141 gcgcagccag gtggacttga cgacgccgct gagggtcttg ccggcgtagg cggtgacccg
     7201 gttgcggtgc tgaagtgccg ccgggtccac ggtgaaggtc tcgtcgggcg ccagcaccgc
     7261 gaagtcggcg tcgcggcccg cctcgatggc gcccttctgg gccaggccga cgagccgggc
     7321 cgtccgtgcg gacatccagc ggacgacgtc ctcgaggctg tggccgcgcc gccgggcctc
     7381 ggtccagatc gcgggcaggc tgagctggag tccggagatc ccgccccacg ccgtcgcgaa
     7441 gtcatcggtc ttcaggtcgg cggtggaggg cgagtggtcg gtgaccacgc agtcgatcgt
     7501 gccgtcggcc agcgcctgcc acagcaggtc ctggttggcg gcctcacgga tgggcgggca
     7561 gcacttgaac tcgctggccc cgtccggaac ttcctcggcc gtgagcgtga ggtagtgggg
     7621 gcaggtctcc accgtgacgc gtacgccctc ggccttggcg ccggcgatca gcggcagcgc
     7681 gtcgctcgac gacaggtgca gcacgtgcac gcgcgcgttg aggcgcttcg cctgcgcgag
     7741 gaggttcgcg atagcggtgt cctcggcgtc gcgcgggcgc gaggcgagga agtcggtgta
     7801 cctggggccg ccccgctggg gggcggcggc gaggtggtgc gggtcctcgg cgtggacgat
     7861 gagcagtccg ccgaagccgg cgatctcggc catcgaccgg gccagccgct cctggtccag
     7921 ctcggggaac tcgtcgacgc ccgagggcga caggaacgcc ttgaagccga agacgcccgc
     7981 gtcgtgcagc ggccgcaggt ccttgacgtt gtcgggcagt gcgccgcccc agaaaccgac
     8041 gtcgatgtgc gccttgtcgg cggccacgtc cctcttggtg cgcagattgc cgaccgtcgt
     8101 ggtcggcggg agggagttga gcggcatgtc gaccagggtg gtgatgcccc cggcggccgc
     8161 ggcgcgcgtc gccgtccaga agccctccca gtgggtgcgc ccggggtcgt tgacgtgcac
     8221 gtgggtgtcg accaggccgg gcagcagcac gtcgtcgccg aggtcctcca ggcgggcgcc
     8281 ggccggcacc tcggcgtcgt gcggcagcac cgccgtgatc ttccccgcgg cgaccgcgac
     8341 cgcggcgggg cgcgtcccct cgggagtgat gacgcgcgtc gagcgcagca ccagttcgac
     8401 gtcggacacc cgggcccctt ccatgccgct gtttacttcc gcgtaacgaa attcaacgtt
     8461 ctgttgaagg agtcttcacc cacggccccc caccgtcaag agtgaacctc tccaccccac
     8521 cctcgacgca cccagcctgg acgtttccac aaagcggaat tatagtttcg gtaggcagaa
     8581 tgtaactacg cacaaccgga gagtcaaccg accgacaggt aggcttcagc tcttcctgac
     8641 cacccgaaag gaacgcgccg tgccgacgtc cagcgccagc accaccgact ccgccaagtc
     8701 gcccgccccg agcggtggtg tccagtccct cgagcgcgcc ttcgacctgc tcgaacggat
     8761 ggcggacgcc ggtggcgaag tcggcctcag cgagctgtcc gcgagcagcg ggctgcccct
     8821 gccgaccatt caccgcctga tgcgcaccct cgtggcctgc ggttacgtac gccagcagcc
     8881 caaccgccgg tacgccctcg gcccccgcct catccggctc ggcgagtccg cgtcccggct
     8941 gctcggcacc tgggcccgcc cctatctcgc acgcctggtc gaggagaccg gcgagacggc
     9001 gaacatggcg cttctcgacg gcgacgagat cgtctatgtc gcccaggtgc cgtccaagca
     9061 ctcgatgcgc atgttcaccg aggtcggccg ccgggtgctc ccgcactcca ccggcgtggg
     9121 caaggcactg ctcgcgaaca cgccggcgaa cgaggtgcgc gcgctgctgg cccgtaccgg
     9181 gatgcccgcc gccacggaga agacgatcac cactcctgac ggcttcctcg ccgcgctcga
     9241 agaggtgcgc cggctcggct acgcgatcga cgacaacgag caggagatag gagtccggtg
     9301 cctcgcggtg tccgtaccgg actcgccgac cgccgcggcc atctccatct ccggcccggc
     9361 gggccgggtc accgaggagg cgacggagaa gatcgtgccg gtgcttcagc aggtggcggc
     9421 ggagctttcg gaggcgctgg cgacttcggg gccgacggcc tgacccgatc tcacggcccg
     9481 gccccggccc gggaccgacg gcggggccgg gccctcacca gcccggctct cgcaccgtca
     9541 tggagcccgg ccctcccatg gcaccgtctt ggagcccgtc gccacgccgg gcatgaggca
     9601 cgcgccgggc atgaggcacg cgccgcgccc ggcgagcggc ggcggcgcgg gccggccggg
     9661 gagccgatca cgccgcgcgc cgaatctcgt cggtgccgag caccgcgcgg ccgccatgtg
     9721 gaaccgtcct gatccctcgg acggacctga gcccgccctc cgcgcaggcg acgggaaggt
     9781 gacgacaggg cctagccgcg cctcggtggt tccccgaaca gctccaccgc gccgcgtacg
     9841 tccgcgaggc cccgggccag cgcgctgacc gagccgatcg cgccggcgat cagcagcagt
     9901 gagcggcgta accgcgggat ctcggggact ccgccgacgg ccatcgccgc cagtgcggcc
     9961 agttcgtcct cggcgatgcc ccggtcgggg aactcgacgg gatgcgcggc gagttcgcgg
    10021 cgcagccggg acacggcggt ccgcagccct gccaccctcg ggtcctcgtc gctgccggtc
    10081 actggcctct gccccaagct ccgcaacaca gctctccccc tcgcacgccg ttgtgcgaat
    10141 gtccttcgta cgtcgctcag ttccccgcgc cgacgatggg cgccggggaa ccgggtcagt
    10201 aaacgccacc cggtgtggtg ggcgccactc cgaggaccga aattcagtcc atggacatca
    10261 cccggtccgc gcgggttcga gcgcacaccc gagccgggtc gggtatgcag ggggaatgac
    10321 cgagaacgag gacctggtgg cggggctcct gctggcggcc ggtggcgggc gtcggctcgg
    10381 gggccggccc aaggcgctcc tggaacaccg agggcgcccc cttgtcgaac atgtggccgg
    10441 agtgctgcgg gcggccggat ccacccgcgt gtatgtcgtc ctgggcgccc aggccgccgc
    10501 cgtacgggag cgcgcggtgc tgcccggctg catcctcgtg gacaacccgg actgggagct
    10561 gggcatgggc acctccctgc gggccgggct ggaggcgatg catggaacgg gggtacgcgc
    10621 cgcgctggtg tcgctcgtcg accagccggg gatcggaccg gcggcggtgg cccgggtacg
    10681 ggcggcgtac acgtccccct cgaccctcgc ctcggccgcg tacgacggag tgcgcggcca
    10741 ccccgtcctg ttcggcgccg cccactgggc ggccgtcgcc gcgagcgcga ccggcgaccg
    10801 gggcgcccgc gcctacctca aggcccatga gtccgcgatc acccttgtcg agtgcgggga
    10861 cgtggccgag gcgtacgaca tcgacacggt cgccgacctc gtccacctgg agtgaacggg
    10921 gtggcactga gcgccatctt ctgtcgactc tgagaatctc gacatcaaca aaccattgaa
    10981 cttccaccat gaggaaacta ctatccactg ttcagaagcg ccggaccgct cccgaggcgc
    11041 ccccagccgc atccgcggcc cctggcaccc ggtgccgcgt cgacgcgcgc acgcgcgcgg
    11101 tccgtatccg tagctcgctg aaggaagtga cagctcatgt ccgcaccagc gccgtccccg
    11161 ctggccctcg tcgacgccga gcccctgccc cggcaggaag aggtcctcac cgacgcggcc
    11221 ctcgccttcg tggccgagct gcaccggctg ttcacgcccc ggcgtgacga gctcctcgcc
    11281 cgtcgcgcgc agcgccgcgc cgagatcgcc cgcacctcca cgctcgactt cctcccggag
    11341 accgccgccg tccgcgcgga cgagtcctgg aaggtggccc ccgcgccggc cgcgctgaac
    11401 gaccgccgcg tcgagatcac cggccccacc gaccgcaaga tgaccatcaa cgccctcaac
    11461 tccggcgcga gggtgtggct cgcggacttc gaggacgcct ccgcgcccac ctgggagaac
    11521 gtggtcgtcg ggcagctcaa cctgacggac gcgtacacgc ggaacatcga cttcacggac
    11581 ccgaagtccg gcaagtcgta cgccctcaag gcgaatgagg agctggcgac cgtcgtcatg
    11641 cggccgcgcg gctggcacct gaacgagcgt catctcgtcg actcgcaggg caggcccgtc
    11701 ccgggcgcgc tcgtcgactt cggcctgtac ttcttccaca acgcgcggcg cctgctggac
    11761 ctcggcaagg gcccgtactt ctacctcccc aagacggagt cgcacctgga ggcccgcctc
    11821 tggaacgacg tcttcgtctt cgcgcaggac tacgtcggca tcccgcaggg cacggtccgc
    11881 gccaccgtcc tgatcgagac gatcacggcc gcgtacgaga tggaggagat cctctacgaa
    11941 ctccgcgacc acgcctccgg gttgaacgcg ggccgctggg actacctgtt ctccatcgtc
    12001 aagaacttcc gtgacggcgg cgccaagttc gtcctgccgg accgcaacgc ggtcacgatg
    12061 acggccccgt tcatgcgcgc ctacaccgaa cttttggtcc gcacctgcca caagcgcggc
    12121 gcgcacgcga tcggcggcat ggcggcgttc atcccgtccc ggcgcgacga agaggtcaac
    12181 aaggtcgcct tcgagaaggt caaggccgac aaggaccgcg aggcgggcga cggcttcgac
    12241 ggctcctggg tcgcgcaccc cgacctcgtc ccgatcgcga tggcgtcctt cgacgcggtg
    12301 ctcggcgaca agccgaacca gaaggaccgc ctccgcgagg acgtgtccgt ggcgcccggc
    12361 gacctgatcg ccatcgactc cctggaggcc aagccgacgt acaacgggct ggtcaacgcc
    12421 gtgcaggtcg gtatccgcta catcgaggcc tggctgcgcg gcctcggcgc ggtcgccatc
    12481 ttcaacctca tggaggacgc ggccacggcg gagatctcac gttcgcagat ctggcagtgg
    12541 atcaacgcgg gcgtcgagtt cgagaacggc gagaaggcca ctcccgagct ggcccgcaag
    12601 gtcgccgccg aggaactcgc gaacctccgc gccgaactcg gcgaggaggc cttcgcggcc
    12661 gggaactggc agcaggccca cgacctgctg ctgaaggtgg cgctggacga ggactacgcg
    12721 gacttcctca ccctgcccgc gtacgaacag ctcgccggct gagcggtcac ctctccgagt
    12781 ggcccaggga cttctccggg gccactcggt cgcgtacgag ccgcttcacg gccgtcggct
    12841 ccggaaagcc ctgctcccgc cggtcccata ccacctcgtc gtccacgcgg acgacgaaga
    12901 cgcccccggt gcccggcttg agcgccagct ccgtcagctc ggtctcgaac gtcgtgagca
    12961 gttcctgggc cagccaggcc gcccggggca gccagcggca ctgggtgcag tactcgatct
    13021 ggacgcgatg agtgtgcggg gtggtcatcc gaggtgcacc gaccaatcct gttcagccgc
    13081 cggtttgccg tgcaggtccg ggacccgttt gagccagttg gggcggcccg cccgggtctt
    13141 cgccgcgcga tgggcgtcct cggcggtgag ttgttctcgg gtggggaagt ccgtggggag
    13201 ccaggtcccg gaggccctga cgcgggcggc gaggtagccg acgtaggcgg cgcgtacgtc
    13261 gtcgggggtg tcgaagcccg gttcgtcggc cagccaggcg tcgggcacct ccgccagcac
    13321 ctcacgcagc agctcctccg tcacccgggg tgccagctcg gcgtccgcgg cacgggtgtc
    13381 gggggcgtaa ccaccgagcg cgtgcgagcg gaagtcgtac gccttctccg gggacgaggc
    13441 gtcccaccgg tggtggaaga cgagggcggc gccgtggtcg atcagccaca gcctcggggg
    13501 cgcgatgccg aacgtgggcc agatcatcag gttcgagctg tgcaccgtgc ggtcgacgtt
    13561 caccgtgagg gcgtccagcc agatcacctt gccggcctcc agcgggtcga cgtcgaaggt
    13621 cttcgcgatc tccggggtga agtcctcggc gcccggcagg tagtccatgc cgagattgac
    13681 tccggcgctg gcgtggagga ggtcctggac ctcctggtgc ggctcgtgct cggcgaccgt
    13741 cgggtcgaag tggacgagga cgagctcggg aaagcgcagt ccgaggcggc gcgccagctc
    13801 gccgacgatc acctcggcga ccagcgcctt gcggccctgc gccgaggcgg tgaacttcac
    13861 gacgtaggtc cccaggtcgt cggcctcgac gactccgggg acggagccgc ccgcccgcaa
    13921 cggggtcacg tatcgaacgg cagtcacttc gcgcagcaca ccggccactg taaaacagtc
    13981 gctcacccga gtgatcggat ttatgcgcgg gccagggggt tgggcagcgg cagatagcgg
    14041 gcgtccgcac cgtccgcgcc cgtccaccgc aggaggaggt tcgtcttgcc ggggagcgtg
    14101 ggtgaggcca gcagttctcc gacttcgggg aggtcgtggc gcgccagttc ccgtcgtacc
    14161 gccggccacg ggtccgttcc cggccggcgt tcggcgagca gggccgcgag ctcggcgagg
    14221 tggttgacga ccaggcagta cacgagccgc tcccagccgg ccgcccggct cacgtcgggc
    14281 agcagcttca ccccttccgc atcccggaag agcgcctgga cgggcatgcc gtcggcgtcc
    14341 acggcgacca gcgtgttctg gaggtgcgcc tcgaggacga ccccgtggcg ggcgaacgcg
    14401 tccagcaccg gcggcaccac ctggcgcaga tacgccgccc accaggccct cggatcgtcg
    14461 agccggtcga gcgggttgcc gtcgaagccc tccaccaggg cggccgcgag gagcggggtg
    14521 gtaccgggca ggagatgggg ggcgagcccg tcgcggacga ggacggccag ttcctcgaag
    14581 gcgaagccgg cggtgcggta gccgcggtcg ctcagccacg ccgcgggccc gcgcgccgcg
    14641 gcgaaggcgt tcgccgccgc ctcgtccgtg cggcggagtt tcagcaggtc gtggcgccac
    14701 agccggcgta cgtcgttggt gatgcgcaca tcgaggctga acttcaggaa gaggtccgcc
    14761 tcgggcgcgt acagcgtgcg gacggcggcc gtcggccaga cggcacaccc ggtccggccg
    14821 agccgtacga ggcggccgtc cgcgaaggcg tcgcggatct ccgggcgggc gccgaccagg
    14881 tccagctgcc agggatgggc gggcagcagc cggtagccgg gcggggcctc ggcgagcgcg
    14941 tcgagcgccg tggtgtcgcc ctcctccacg accgtgtccg cgcgcacccc cagcaggacc
    15001 agcgggaaac gggcgtacgc ctcgggcgcg tagggcagcc atccggtgac ggggccgccg
    15061 ccgcgggcct tgggcgccgg atggtgggga tggccggtga tcagggactg ttcggagcgc
    15121 agatacgggt cgtccggcgg cgtcgcgcgg gcgcgcgcgc cgagcagcgc ggccaccgcg
    15181 tcccggctgt cgaccatctc gccgggcagc tcggaattgg acagaccggt gccccggcgc
    15241 agttcctcgg cgacgagttt caccagctcg gcatgggtca gccggtgcca ggcgccgcct
    15301 gcgtacacct cggggtcgcg ggggcggcgg tccccgcgta cgcgcagcag cctgccgccg
    15361 gagcgcagcc ggtacacgcc ctgatcgccg gcgggttccc ccatttcccg cagcagacag
    15421 ttcagcagcg gcgcgtccgc ataggcgtcg gcggccggtc cgacgtcgtc cccgggggac
    15481 atcgggatca tggggtccac gcgatccatt cgttccatac ggtccatccg gtgcactggc
    15541 gatcagtatg tctgtcgtcg tgtgccgccg cgacgccgta cccgtccccc gaggagcccg
    15601 accgtgcacc gtcccgccac cgcagagtcc gagctcgccg ccgagctcga cgccgtacgg
    15661 cccggcctgt cggcgccgta cgcggccgcg ctcccgggcg cccgtgcggc cgtcctgacc
    15721 cggctgtggc gggcgctggc ccatgagccg ctgccgtgga tcgcgcaccg ggagccggag
    15781 cccggcggac tcacgctgcg gctggccgac ggacgccggc tgcacggccc gccctcggac
    15841 ccgtacgcga ccgctccgta cgtcaccggc gtgcggctcg acgagacgtc gtacgcgcat
    15901 ccggcccggc tggtgtcggc gctcggcgtc ccgcacggcc cggccctggc cgccgaactc
    15961 gaccacagtg tcgcctcgtt ggccctgtcg cgggccggtc agccgcgggt cgacccgaag
    16021 tcgccgacga cgagctggga gtgggaacag cgggtggtcg acgggcatcc gttccacccc
    16081 aactgccgtt cccggcccgg cttttcggcc gccgagcagc tcgcttacgg gcccgagcac
    16141 cggccggtgg tgcggctggg cctcgtggcc gtggaggagt gtctcgtccg gggcgagtgg
    16201 cccaagtggc tgcgggacgg ggagcgcgtg ctgattccgg tccacccctg gcagacggca
    16261 cacgtgctcg acgcaccggt ggaggacggg ccggccgccc acccgctgat gtccttgcgg
    16321 accctcgcgc tccgcgacgg cggcccggac gtcaagaccg cgctcagcgc ccggctgaca
    16381 tcgtccgtgc gggacatctc cgtgtactcg atcgagacgt ccgcgacggt gtcggagttc
    16441 gccgaggcct tcgccgcccg cacggacggc ctgctgcaca tcacccgcac cctgggcgcg
    16501 gccacggccg gccggcccga gctggccgcg gtggtacgcg agtccccgga cacgtacgcc
    16561 gacgcggagg cggcggaacg tgtcgttccg gtggcctcgc tcaccggtac cgggctgccc
    16621 ggctctcccg cgtggctcgc cgagttcacc cggctcacgc tcaccgtggg tctgcggctg
    16681 ctcgacctgg gcgtggccct ggaggcgcac ggccagaacc tcctggtggt cctgtccgcc
    16741 acgggtgccc cgctgcgcct cgtgtaccgc gacctcgccg acatccgcgt cagcccggcc
    16801 cggctggccc ggcacggtgt cccgctcccg gatctcggcg ggcgtctcgt cacggacgac
    16861 gaaaccaccc tgcgccgcaa actgttcggc tccctcgtcg cgggcgcgct ggcggcgacg
    16921 gcggggtcgg ggccggcgct gcgggaggcg ctcgccgccg cggcgcggga tctgccgcgc
    16981 acccccgatc tgacggcgct gctcgaagag ccgctgccgg ccaaggcgtt gacgctgatg
    17041 cggctgtcgc ccgaccggcc gggggacagc tgggcacagc tgcccaaccc gctcgtcacg
    17101 cgcgcgttct gagaccggag cccgctcgtt ttgaagcccg gaccctttga tcaataggat
    17161 ccgccgatga tcacaagaca acggctggcg gtggggctct gcgctctgct cgccgccctg
    17221 acggccgggt tcgccttccc ggccggcgcc gtcgccgacg agacgacagc cgacgcgccc
    17281 aaggtggacc tcgtcctcga cgtcagcggt tccatgcggg cccgggacat cgacggcgga
    17341 tcccggatgg ccgcggcgaa gcaggcgttc aacgaagtgc tggacgcgac gcccgaggag
    17401 gtgcggctcg gcattcgcac gctgggcgcc aactacccgg gcgacgaccg caagacgggc
    17461 tgcaaggaca ccgcgcagct gtacccggtc tcgacgctgg accggaccga ggccaagacg
    17521 gcggtggcga cgctctcgcc gaccggctgg acaccgatcg gcccggccct gctcaaggcg
    17581 gccgacgacc tcgacggcgg caccggctcg caccgcatcg tcctcatcac cgacggcgag
    17641 gacacctgcg cccccctcga cccgtgcgag gtggcccggg agatcgcggc caagggcgtc
    17701 gggctcacca tcgacaccct cggtctggtg ccgaacagca agctgagcaa gcagctcagc
    17761 tgcatcgccg aggcgaccgg cggcacgtac acctcggtgg agcacaagga ggacctcacc
    17821 gacaaggtca accagctggt ggaccgcgcc gccgacaagg tggtgacgcc ggtcgccgtg
    17881 gacggcgccg ccgactgcgc gaaggcgccg acgctgaagt ccgggctctt cacggaccgt
    17941 gcggagttcg cccagcaccg ctggtaccgc gtggacgtga agccggggca ggagctgcgc
    18001 gcctcggtga gcctctccgc cgaccgtcag gtgaacccgg actacggggt gttgctgcgg
    18061 gcggtgaccg tgcacaaccg tgagatcgtc cgcggtgagg ccgcgggcac gggccgtacg
    18121 gacgtcgtgt cgacgggtct gcgctatccg aaggccgaga gcgacgacga ggacgccacc
    18181 gccgagacgg tgtgtctcca ggtctcccac tccttctcgc cggccgccgg cgtgaagacc
    18241 acgcccggac tgccgctgga gctgaccgtc gacgtggtgg acggacccga ccaggcgggc
    18301 gacgtggcct cgttcggcct cgggcgcggc tggtggctgc tcggcgccct ggtgctgacc
    18361 ggcttcctcg cgggtctgct gtggggctgg ctgtcgcgct ggcggttcgc ggtctggagg
    18421 accaactgat gcgtatctca cgtgtactga agtcaggtgt ccggaactcg ggtgtcctgg
    18481 tcgcggcggg tctgctgctc ggcgccgccg tggcaccggc cgtcgccgac tcctcgccgt
    18541 ccgcgagccc ctccggggac agtgccgcgc ccacctcggc gggcacctcg ttccgtaccg
    18601 cgaccgagat cgcgcagggg cagcgggcca cggccggcgg ctccgcgggc gactacctgt
    18661 actggtcgtt ccccgcggac accggtctgc ggcccaccgt gaaggcgacg gtgaagttcc
    18721 cgcagtccgc cgagcgcggc gcgagccaga cctggcagct cgacgtctac gacgggctgc
    18781 ggcgccgcca ggcgtgccag tacggggcgc agacgcggac ggccgcccag gacgcgacct
    18841 ccgtcgacct gtcctgcacg ctgcgcacgg tccgcgcgtg gtcggagccg tgggccgatg
    18901 atccgctgcc gggcacgtac tacgtccggc tgaccctggt cgacgtggcg acgggcgacc
    18961 tggggctgcc ggtgagcgcg gaggtccagg tggactccaa ggacatcggc ggttcggcgg
    19021 cggtcgacgg gtcgctgtcc cagccgctgg tgccggggat cgcgacggcc tccgacacgt
    19081 cggacgaggg atcggactcg gccaaggcct cgctgttctc actggagccc gacgacggct
    19141 gggcctccgg ctggtggacc gaccgctggg tgtggacggc gatcggcggc atcctcgcgg
    19201 cgctcgccgg aatcggcggg tacgcgctga cgaagggctc gggccggccc aggcaggtac
    19261 caccgggcgc gtgacggacg cgcgcgacaa ggcggaggcc cgccgtgccc catggcacgg
    19321 cgggcctcct tgtgcgtgcg ggtgcggggc gggtgacccg tgcgggggcg ggcgaccgtg
    19381 cgggggtggg tgcgcgtgcg ggggtgggtg cgggtggccc gtgcgggggt gggtgcgggt
    19441 gcgcggggcc gcaagggcgg gtgcacgggg gccgtacggg ggccgcgcgg acggcgaccc
    19501 gcaccagacg gacgggagac ggcccgtggg aacaggcgga cggacggccg cgcgggacga
    19561 acgggcgacg gcggcccgcg caggacaggc agccgacggc ccccaccaga cggacgggcg
    19621 accgcccgcg cgagaccgac gggcggtgtc agtcgccgcg cagcagcttg gcgagcgcgc
    19681 tctcgcccgt gatctcggcg cggccctccc gtacggcctg atggagcgtc aaagtctcac
    19741 ggctcagggc catacaggtg tccgcgtcga tgaccagacg cgcgtcgggc tcctcggggg
    19801 ccggtccctc gccgtacgcc gggccctccg ccgcacccag gtgcagatgg aaccgccctt
    19861 cctccaggcg gatttcgagc aggccgacgg caaggccgtc cccctccagc gagcgcagca
    19921 acggcagcgc gaaccagtgc gcgcgcaccg cgtccgtggc ccggcgctcc gccagcgcgg
    19981 gcgcacccca gctgcccagc gcctggagaa cgggcagcaa ctcacgcccg cgcccggtga
    20041 gttcgtacac gtacaccgca cccggcggcg gcaaccggcg ccgggtcgtc agcccgtcgc
    20101 gctccatgtc cttcagccgg gacgccagta cgtcggtact cacacccggc aggtccgcgt
    20161 gcagatcggt gtagcggcgc gggccgccga gcagctcgcg gacgatcagg agggtccagc
    20221 ggtcaccgac ggcgtcgagg gctcgggccg cggaacagta ctggtcgtag cttcggcgag
    20281 gtggcatgcg acgcagtcta gacatgttgt tggactttcc aagctctgac ttggtaaaac
    20341 caagtaacac cacgaaccgg agggcacagc gcatggagtt ccggcagtcg agcaagctca
    20401 gcgaggtctg ttacgagatc cgcggcccgg tgatcgagca cgccaacgcg ctggaggagg
    20461 cgggccacag cgtgctgcgc ctgaacaccg gcaaccccgc gctcttcggc ttcgaggcgc
    20521 ccgaggagat cctccaggac atgatccgga tgctcccccg ggcgcacggc tacaccgact
    20581 cgcgcggcgt cctctccgcc cgccgcgccg tggcccagcg ctaccaggac cgtggcctgg
    20641 aggtcgacgt cgacgacgtg ttcctgggca acggcgtctc cgaactcgtc tcgatggccg
    20701 tacaggcgct gatcgaggac ggcgacgaag tcctcatccc ggccccggac ttccccctct
    20761 ggacggccgt caccacgctc gcgggcggca aggcggtgca ctacctctgc gacgagcagg
    20821 ccgactggta cccggacctg gcggacatgg ccgcgaagat caccgaccgc acgcgcgccg
    20881 tggtcatcat caaccccaac aaccccaccg gcgcggtcta tccgaaggag atcgtcgagg
    20941 gcatcctcga tctcgcccgt cggcacggcc tgatggtgtt cgcggacgag atctacgacc
    21001 agatcctgta cgacgacgcc gtgcaccact cggccgccgc cctcgcgccc gacctggtgg
    21061 tcctcacctt ctgcggcctg tcgaagacgt accgcgtggc cggcttccgg tccggctggc
    21121 tggtcgtcac gggccccaag cagcacgccc gcagctatct ggagggcctg acgatgctcg
    21181 cctccatgcg gctgtgcgcg aacgcccccg cccagtacgc gatccaggcc gcgctcggcg
    21241 gccgccagtc catccaggag ctgaccgcac cgggcggccg gctgtacgag cagcgcgacc
    21301 gcgcctggca gaagctcaac gagatcccgg gcgtctcgtg cgtgaagccg aagggcgcgt
    21361 tgtacgcgtt cccgcgcatc gaccccaccg tgcacaagat ccacgacgac gagaagttcg
    21421 tcctggacct gctgctgcgg gagaagatcc aggtggtcca gggcaccggc ttcaactggc
    21481 cccgccccga ccacttccgc atcctcacgc tcccccacgc ggacgacctg gacgcggcga
    21541 tcagccggat cgggcggttc ctgagcgggt accggcagta agaccgtccg gcacattggg
    21601 gctgtccggc gcagtagggc tgtccggcgc agccggacct gcggccggca cccggcggtg
    21661 tcaccgtacg aagggacaga aagggtgtgg cgatgggtga ccttctcctc gtacggcacg
    21721 gtgagaccga gtggtcggtg tccgggcggc acacggggtc gaccgacatt ccgctcaccg
    21781 agaacggacg ggagcaggcg cgcaggctgg ctccgctgat cgcctcgcac cacgtcgggg
    21841 ccgcgttcgt cagcccgatg cggcgggcgc gggagacggc gcggctggcg gggctcgacg
    21901 gggcgcgcgt cgacgcggac ctgagcgagt gggactacgg cgggtacgag ggggtcacga
    21961 ccgtcgagat ccaccggacc cggcccgact ggttcctgtt cacggacggg gtcgagcccg
    22021 gcccgccgga gcaccccggg gagagtccgg aggaggtcgg ggcgcgcgcg gagcgcatgc
    22081 tggccaaggt cgacgcggcg ctcgccgaca cggagggcag tgtcgtcgtg gtctcccacg
    22141 gtcacttcct ccgcgtgctg gccgcgcggc ggctggggct gcccgcctcg ggcggcgccc
    22201 tgttccagct cgcgaccgga acggtgagcc ggctgagcac ggagcaccgc cgccatgtgg
    22261 tggccagctg gaatgtcaga ccctcctcgt agtcttcaag tgggccggtc agcaggccgc
    22321 ccgccgagag gacgaaggaa ggagcgccgc cgtgacccga ccgccgaccg ccgcgcagcg
    22381 gcgcgtcatc gaggccgccg atcccgtcac cgggcgactg aaggggaccg aggcccagct
    22441 cgccgccctg gtgaagcgag gactcgcctt ccggcatccg cggccgccgc acgaccactt
    22501 tctgacgccc gccgggcatc gcatacgtga agctcccgag ccggtcgtcg agacacccgc
    22561 gccggccgag gccgggtccg gcgtgttcgc cgcgcggatc ggcggcgagg agggcgaggc
    22621 cggcccttcc cgcctccgcg aggtgcacag tgcctggcag gggctcctgg agttgcgccg
    22681 gatgaccagc ccggacggtg ccgtcgaccg tccgtgcggg tgggagcgtg cgcatctggt
    22741 gcaggccgcc gcgctcgcgc tggaggccgc ggggcaccgg ccggcaggca cggacggtgg
    22801 tgggtaccgg gtgcgcgcga ctccccagcc ggaggcggtc gcggtacagg agccggaccc
    22861 ggaggcgttg cgcgcctgcg cggccacgct ggagaaggcg ggctggcagg tcggcgagca
    22921 cgcggagccg cgcacggggg cgcggtatgt gctggcctca ccgaggcgcg tatgaggtct
    22981 cgccccggcg gcccgaagcc cgaagcccga agcccgaagc cccaaagagc ctacggggca
    23041 agggaattgg agatccctcg ctcactagtg ctccgttagt gttgcgtccg tcctgatcgt
    23101 cgtagagggg gaagtcgtgg cagagccgtt ttccgtagca gtgactgtcc gcgggtacga
    23161 gaccgatgtg cagggacacc tcaaccagag cgtgtatctc cagtacgcgg agcacgcccg
    23221 ctggtcgctg ctgcacgcgg ccgggatcag ccagacggag ctgacaggca agggcgtggg
    23281 tccggtgacc ctggagacca ccatccgcta caaacgggag ctgcgcgcgg gggacgaggt
    23341 cgaggtgacg tgcggcttcg tctggggcga gggcaagagc ttccgcgtcg agcagacgat
    23401 ccggaagacg gacggcacgg tgtccgccga gctgacggcg gtcggcggac tgctggacct
    23461 caaggagcgc aggctggtcg cggacccacg cgagtacttc cgcgcactgg ccgccgaccc
    23521 gggtttgttc gacctctgac cgtcaatcac gaccccgcgc ccgccgtgtt gtagagcggg
    23581 tgcgcggcct cctacccatc cagcagttcc ggccggtgcc gggcgtcgta ggccgcgcgc
    23641 gactgtgcga cggtgacccg gtgccgctcg gcccagtccg tcagcgacag cagggtcgcg
    23701 tgcaactccc ctgccaccgg ggtgagttcg tactcgacct tcggcggcac cgtcgaatgg
    23761 acggtgcgcg tcacgagccc gtcccgctcc aggttgcgca gggtcagcgt gagcatccgc
    23821 cggctgatgc cctcgatgct gcgctccagc tcggtgaagc ggatcggccc gtgcgcggcc
    23881 gcgacgatga tctgcacgct ccacttgccg gcgaccctgt caagaacttc gcggacgggg
    23941 cacgcgtgcg cgttcacgac ctgcgccgta acagcggtgt tcccttggga cattcaggtg
    24001 cctccttatg ccggtatcca tggtcaccca cgatgtactc cgttacaagt cgtgcaccta
    24061 aggtgctttc ggagaccacg gaggtcagcc agccatgtcg ttcctgatcg agtcccgcac
    24121 gcgacagcga cagcgaacgc cctcccggtg ggcgtccctg gtcgtcctgt gcgcgggtac
    24181 gttgatgacg gtcctggacg gcaacgtcgt gaccgtggcc atgcccgcga tccagggcga
    24241 cctcggcttt tcgggccctg ggctcgcctg ggtggtgaac gcgtatctga tcccgttcgg
    24301 cggactgctc ctgctggtcg gccgcctggg cgacctcgtg ggcggcaagc ggatgttcac
    24361 ggcggggctc gccgtcttca ccgtggcgtc cgtgctgtgc ggggtcgcca ccagccaggc
    24421 cacgctggtc gcggcccgcg ccctgcaagg gatcggcgga gcgatgacct cggccgtcgt
    24481 cctcggcatg ctcgtcgccc tcttccccga accgcgtgaa caggcccgtg ccatcgcggt
    24541 gttcagcgcg gtaggcgcgg cgggcggggc gctcggcaca ttcctgggcg gtgcgctgac
    24601 ccaggccctg aactggcact ggatcttcct gatcaacctg ccgatcggcg tactggcctg
    24661 gctcgccgcc ctgcggttcc tcgccccgga gcggggtgcc gggctcggca ggggcgccga
    24721 ctacccgggc gcggcgctgg tcacgggcgc gctgatgctc acggtgtacg cgatcgtcgg
    24781 cgccggcgac cgcgggctcg ccggcacgct ggtcctcgcg gcggtctcac tcgccctctt
    24841 ctccgcgttc accgtccgcc aggcccgagc ccctcgcccc ttgctccgtc tgcgcctgtt
    24901 ccgctcgcgc gtgctgaccg gcgcgaacgc cgtgcaggtc ctgatgatcg gggggatgtt
    24961 cggcttccag tacatcggcg cgctctatct ccaacgcgtc cttggatacg gtgagttgct
    25021 caccggaacg gctttcctgc cggcgccgat cgcgatcggg gtgctgatgc tgggcctgtc
    25081 ggcgcggacg atcgcccgct tcggcccgta ccgtgtgctg ctctcgggtc tcgtgctcat
    25141 ctccgccgga atggccctgc tgagccgtgc gccggtcgac ggcacctacc tcgccgacgt
    25201 cctgccaccg ctgcttctcc tggccgccgg tttcgctgct gccatgcccg ccgtgacggg
    25261 gctcgcgatg tcgggcgccc gtgcggagga cgccggactc gcctccgggc tcttcaacac
    25321 cacacaggtg gtgggcggtt cgctgggtct cgcggtgctg acgaccctgg cggcgagccg
    25381 caccgaccat ctgcggcacg ggggcgccga cctcgtggcg gccaccgcgt ccggctaccg
    25441 gctggcgttc atggtggcga cgggcatcgc cgtggcggcg ctggtgctgg cggcgggggt
    25501 gctgcgaacg gagcgtgcca cctcggggca gcccccggcg aacaccccca ggtgatccgc
    25561 acccacgcgt cacagcacgt acgccgccgg ccccgctccc ccatctggcc ggaacgtgcg
    25621 ctcagaccgc ggcccagcgg gtatccctgc acacggcgat ccccgcacac ggcgtcaccg
    25681 cacccgcaca cgatcccttc catgcccacg gacccgccca ccacccccac cgcggaacga
    25741 gggagacccc atgccgctgg cgcgccgcgt cctcctgacc gctctcgccg ccgggtccgc
    25801 gggcgccgcc gtcgcctgtg acccggcctc ggccgacgga gcgcccgcgg cgggctcggc
    25861 cgcgacggcc gcccgccggc tcctcccccg tcactggcgg cagctgacgt tccgcacggc
    25921 gggcggacgc gacacgttcc aggtgtccgg ccgtacgggc cgcgtcaccg tcacgggcgg
    25981 cacaccggcg acccagctca cggggctgaa ctggtacttg aggaacatcg cggacgccga
    26041 catcaactgg gcgggcaggc agctccgcct gccccgcgca ctgccgggcc tcgccggcac
    26101 agtgacccgg cgcgcgaacg tcccgcaccg cttcgccctc aacgacacga acgacggcta
    26161 cacgggcccg taccacgact ggacgtactg ggagcgtgag ctcgacgtac tggccctgca
    26221 cggctacaac gaagtgctcg tccaaacggg cgcggacgcg ctccaccacc gggtgttcca
    26281 ggagttcggg tacaccgacg aggagctgcg gaagtggatt ccggggccgg cccatcagcc
    26341 ctggtggctg ctgcagaacc tctccgcctt ccccgacccc gtctcacaac agctcctcga
    26401 cgcccgggcc gcgctcggcc ggcgcatcgc gaaccggctg cgggagctgg gcatgacacc
    26461 ggtgttcccc ggctacttcg gcacggttcc gccgggcttc gccgaccgca acgcgggtgc
    26521 gcacaccgtc ccgcagggca cctggatggg cttcgccagg cccgactggc tggacccgcg
    26581 caccgagcac ttcacacggg tggccgcggc cttctaccgg atccaggacg agatgttcgg
    26641 cggcgcctcg acccgctaca agatggacct gctgcacgag ggcggcagcc ccggtgacgt
    26701 gcccgtcggc gacgcggcga agggcgtcga gagggcgttg cgggccgcgc acccgggcgc
    26761 cgtatgggtg atcctgggct ggcagcacaa cccgcccagg gcgatcgtcg acgccgtgga
    26821 caaggaccgg atgctcgtcg tggacggcct ctgtgaccgc ttcccgaagg tcaccgaccg
    26881 cgaggcggac tggcacggca ccccgtacgc cttcggctcg atctggaact tcggcggcca
    26941 tacgaccctg ggcgcgaaca ctcccgactg ggcttcgctg tacgagcggt ggcgcaccag
    27001 gccgggcagc accctgcgcg gtgtcgctct gctcccggag gccgcggaca acaatccggc
    27061 cgccttcgcc ctgttttccg aactcgcctg gcgcgagggc gacttggacc tgcgcgcatg
    27121 gttcgcgcgg tgggcgcgct cgcgctacgg gggacgcgat ccacatgcgg aggccgcctg
    27181 ggacatcctg cgccggaccg cgtacggcac cacgcgcgcc gactcgtgga gcgagggcgc
    27241 ggacgggctg ttcggggcgc gcccctccct cgcggcgacg aaggcggctt cctggtcgcc
    27301 gaagcgcctc cgttaccggc ccgaggagtt cgaaccggcg cttggcgagc tcctgaaggt
    27361 gcggccgggg ctgcgcggct cgtcggcgta ccgccgcgac ctgctcgacg tggcccgcca
    27421 ggcactctcc aaccgcagcc gggtactcct cccgcagatc aggacggcgt acgaggccaa
    27481 ggacaccgcc cgcttcgacc ggctgaccgg cgtctggctg gccctgatgg acctgctgga
    27541 ggcactcctg gccaccgact cccgtcatct gctgggccgt tgggtggccg acgcgcgggc
    27601 gtggggtgcg agcgcggcgg agcgggaccg gctcgcgtac gacgccctct cgctgctgac
    27661 cgtgtggggc acccgcgcgg gtgcggacgc cgggctgcgc gactacgcca accgcgagtg
    27721 ggcgggactg gtcggcgggc tgtaccggct gcgctggtcg acgtacttcg cggagctgcg
    27781 gtcggcgtcg cgggagggac gcacgccgaa gaagaccgac tggttcgccc tggaagatcg
    27841 ctggacccgg aatcccgggg gcctggcgac gcggcccacg ggtgacacgt accaggccgc
    27901 cgtccgggtg cacgaacggc tgaccgccga gcgatagccg gggcggccgg gggcggcacg
    27961 ggaaccgact cagctttctt gacgggtata cgtcaccctc gaactctggt aggaaacttt
    28021 cctaacagta cgcggaacga cgaactcccc ctcttggagg taccgtgcac tccccccaca
    28081 tacgcacctc acgccgcacc ctgctcgccc tgatcggagc ctcactggtg gcaggcccac
    28141 tcgtcgcgaa ccagtccgcg accgccgcac ccgtcggcct ggacgacccg gcgaagaaag
    28201 agatcgccat gaagctcgtg tccagcgcgg agaactcctc gctggactgg aaggcccagt
    28261 acaagtacat cgaggacatc ggcgacggcc gcggctacac cgccgggatc atcggcttct
    28321 gctccggcac cggcgacatg ctcgacctcg tcgagctcta cacccagcgc aagccgggga
    28381 acgtcctggc cacgtatctg cccgccctgc gcaacgtcaa cggcggcgac tcgcaccagg
    28441 gcctggaccc gggcttcccc ggcgactggc gccgcgcggc ccaggactcg gcgttccagc
    28501 aggcccagaa cgacgaacgc gaccgcgtct acttcgaccc ggccgtccgg caggggaagg
    28561 cggacggtat cggcgtactc ggacagttca cgtactacga cgccatcgtc atgcacgggg
    28621 acggcggtga cagcaccagc ttcagcagca tccgcgggcg cgccctggcc aaggccgagc
    28681 cgccggcgca gggcggcaac gaggtgacgt acctgaacgc cttcctcgac gcccgggtct
    28741 gggcgatgcg gcaggaggag gcccactcgg acaccagccg ggtcgacacc gcccagcggg
    28801 tcttcctgac gaagggcaac ctgaacctgg atccgccact ggactggaag gtgtacgggg
    28861 acagctacca catcggctga cccccgcgcg aggccgcggc cgaggcgcac ggccgggacg
    28921 ccgcggctcc gtgccggaca cggagccgcg cgcgagcccg gacacgcaag gcgcctgcga
    28981 gccgggtcag tgtgccgtca ccgcggaagg ccccgcggcc ggggagccgg ccccgccccg
    29041 ctgcccggcg atctcctcgc ccggctccat cggcgccgtc acctcgtcgt ccccctggcg
    29101 cctgcccaga tggttgaaga ggaggttcag caccacggcc gccacgcacc cggtcgagat
    29161 ccccgagtcc aggacgatct tcgccgtctg cgggaacgcg tggtagaact ccggcgcggt
    29221 gatcgggatg atgccgaccg ccagtgacac cgccacgatc aggacgttgt tgtccttctc
    29281 caggccggcc cggaccaggg tctggatgcc gctggccgcg accgagccga acaggacgac
    29341 gcccgcgccg ccgaggacgg gccggggcac gaccgcgatc agcgaggcgg ccacgggaca
    29401 caggcccatc aggaccagga agccgccgcc ggtggcgacg acgtaccggc tgcggatcct
    29461 cgtcatcgcg accaggccga tgttctgcgc gaaggcgctg cacatgaacc cgttgaagag
    29521 ggggctgagg gccgagccga gggtgtcggc gcgcagaccg gcggcgatgg tccgctcgtc
    29581 ggcggggcgt ccgacgatct cccccagcgc cagcatgtcc gccgtcgact cggtcatcga
    29641 gaccaccatg accacgctga gggagaggat cgcggcgagc tggaaccgcg gtgcgccgaa
    29701 gtggaacggc gtcgggaagc cgatcaggtc cgctccggcc accgggccga agtccgtgac
    29761 gccgaggggt atcgcgagca gcgtgccgat gaccaggccg agcaggacgg cgatctgctt
    29821 gacgaagccg tgggtgaagc ggcgaaggag cagcacgatc acgagagtcg cggcggcgag
    29881 ccccaggtag gtcgtcgaac cgtaggagtc cgccgtgggg tcggggccct gggcccagcc
    29941 gaaggcgacg ggcagcaggg acacgccgat gagggtgatc acggtgccgg tgacgaccgg
    30001 cgggaagaag cggacggcct tgctgaagaa gggggccgcg acgaagccga gggcgccggc
    30061 gacgatcacc gcgccgaaga tgatcgggag ggcgtcggac ctgtccttgg tggaggcgac
    30121 gatcgcggtc atgggggcga cgccggcgaa ggtgacgccg ttgacgaacg gaagccgggc
    30181 accgatcttc cagaagccga gggtctggag gaaggtggcg aggcccgcgg tgaacaggca
    30241 ggcgccggtg aggaaggtca gctcggtgcc ggagaggccc gcggccgcgc cgacgatcag
    30301 gggtggggcg acgacgccgg cgtacatggc ggccacgtgc tggaggccgc tggtcgtcat
    30361 cttcagaagc gggagcttct cgtcaactgg atgccggggc tggtcggttg ggactgcatc
    30421 ggtgctgggc gatggctggg cggccacggc ggctcctccg gtcgggtgca cgtcgtcgtc
    30481 gacgtgggtt tcagggaggt gatgcgcggt cgtgcgggac cgggacggac accgttccgg
    30541 ggcgcgcaca gccatgcgcg ccccggacgc ggccgccatg aaccccgctc gggtccacgg
    30601 ctaccggccg agggccgtcc ccctcggccg gagatctccg gttgtcaggc ctgcgcggcg
    30661 atccgcgcca gccgctgcgc ctcttcccgc gtggagcggg cgacggcgtc ctcgtcgacg
    30721 tgcagcagcc ggctgttctc gacgaccggc tcgccgccca cgagggagag cgtgaccgga
    30781 gccgcggcgc cgaagaccag ggcggtcacc gggtcggcga tcgaggcgtg ggcgagcgtg
    30841 tcgagcttcc acagcaccag gtcggccagc ttgcccgtct ccagggagcc gatctcggct
    30901 gcccggccca ggacttgggc gcctccgtag gtgccgaggc gcagtgcctg acgggcgttc
    30961 agggcggctt cgcggtgggc gccgagacgg ttgatgagga gggcgttgcg caactcggtg
    31021 tgcagctcgc cggattcgtt ggaggccgtg ccgtcgacgc cgaggccgac ggggacgccc
    31081 gccgccagca tgtcggggac ccgggcgatc cc
//
