LOCUS       NC_003155              13033 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2108850
            Orig. end                         :: 2121883
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..13033
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="12"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..13033
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13033
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8033](-)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..8033)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    45..60
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    complement(219..232)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.43"
                     /tool="antismash"
     misc_feature    complement(1277..1290)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.92"
                     /tool="antismash"
     misc_feature    1277..1293
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.59"
                     /tool="antismash"
     misc_feature    1278..1291
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.26"
                     /tool="antismash"
     gene            complement(1318..2310)
                     /db_xref="GeneID:41538828"
                     /locus_tag="SAVERM_RS09130"
                     /old_locus_tag="SAV_1728"
                     /old_locus_tag="SAVERM_1728"
     CDS             complement(1318..2310)
                     /codon_start=1
                     /db_xref="GeneID:41538828"
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191565.1"
                     /locus_tag="SAVERM_RS09130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1728"
                     /old_locus_tag="SAVERM_1728"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_010983167.1"
                     /transl_table=11
                     /translation="MTRRLAEVAKKVGVSEATVSRVLNDKPGVSPATRQAVLSALDVLG
                     YERPTQLRGERARLVGLVLPELQNPIFPAFAEVIGGALAQLGLTPVLCTQTKGGVSEAD
                     YVNLLLQQQVSGVVFAGGLYAQADAPHDHYRRLADRNIPVVLVNAAIEHLGFPAVSCDD
                     AVAVEQAWRHLASLGHERIGLVLGPGDHMPSARKLAAARALGDLPDEYVARAMFSIEGG
                     HAAASRLIDRGVTGFICASDPLALGAVRAARRKGLDVPSQISVVGYDDSALMNCTEPPL
                     TTVRQPIESMGRAVVELLNARIGGSSVPDEELLFEPELVVRGSTAQAPR"
     gene            complement(2357..3028)
                     /db_xref="GeneID:41538829"
                     /locus_tag="SAVERM_RS09135"
                     /old_locus_tag="SAV_1729"
                     /old_locus_tag="SAVERM_1729"
     CDS             complement(2357..3028)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538829"
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994286.1"
                     /locus_tag="SAVERM_RS09135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1729"
                     /old_locus_tag="SAVERM_1729"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_037645866.1"
                     /transl_table=11
                     /translation="MAAQHSPALPTLGGRKPSYRERVADALRAALIAGELRAGEVYSAP
                     GLAARFGVSATPVREAMLDLAKEGLVDTVPNKGFRVTAVSEKQLDEYTHIRSLIEIPTT
                     AGLALTADPAELEALRPVAREIVAAATAGDLIAYVEADLRFHLGLLALAGNDHLVDVVR
                     DLRRRSRLYGLTALARAGRLRASAEEHLELLDALLARDTEAAREVTTRHLGHVRGLWVA
                     P"
     gene            complement(3098..4099)
                     /db_xref="GeneID:41538830"
                     /locus_tag="SAVERM_RS09140"
                     /old_locus_tag="SAV_1730"
                     /old_locus_tag="SAVERM_1730"
     CDS             complement(3098..4099)
                     /codon_start=1
                     /db_xref="GeneID:41538830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358096.1"
                     /locus_tag="SAVERM_RS09140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1730"
                     /old_locus_tag="SAVERM_1730"
                     /product="proline racemase family protein"
                     /protein_id="WP_010983169.1"
                     /transl_table=11
                     /translation="MRSKLVLHAVDSHTEGMPTRVITGGIGTIPGATMNERRLYFREHR
                     DDIRQLLMNEPRGHSAMSGAVLQPPARPDCDVGVVYIEVSGYLPMCGHGTIGVATVLVE
                     TGMVEVVEPVTTIRLDTPAGLVVAEVAVEDGAARAVTLKNVPSFCVGLDRKATLADGRT
                     VTYDLAYGGNFYAILPLGEFGLPFDRSRKDDILKAGLSLMDAVNADGGPVHPEDPSIRG
                     CHHVHLVAPGSDARHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGELPLGTEFVNES
                     LIGTRFTGRLLGTTEVAGIPAVLPSFTGRAWVTGTAQYLLDPEDPFPAGFVL"
     gene            complement(4114..5004)
                     /db_xref="GeneID:41538831"
                     /locus_tag="SAVERM_RS09145"
                     /old_locus_tag="SAV_1731"
                     /old_locus_tag="SAVERM_1731"
     CDS             complement(4114..5004)
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525029.1"
                     /locus_tag="SAVERM_RS09145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1731"
                     /old_locus_tag="SAVERM_1731"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_010983170.1"
                     /transl_table=11
                     /translation="MTVHRPWRGVLVATALPLTADLAVDHDKFAEHCAWLVEQGCDGVV
                     PNGSLGEYQVLTPEERARVVETAVSAVGGARVMPGVAAYGSAEARRWAEQARDAGCRAV
                     MLLPPNAYRADERSVRAHYAEVAKAGVPVVAYNNPIDTKVDLVPELLAALHGEGYIHAV
                     KEFSGDVRRAYRLAELAPELDLLIGADDVLLELAVAGAKGWVAGYPNALPAASVELYHA
                     AVDGDLATATQLYRQLHPLLRWDSRVEFVQAIKMSMDVVGRYGGPVRPPRVPLLPEQET
                     AVRAATEKAVAAGLA"
     gene            complement(5001..6500)
                     /db_xref="GeneID:41538832"
                     /locus_tag="SAVERM_RS09150"
                     /old_locus_tag="SAV_1732"
                     /old_locus_tag="SAVERM_1732"
     CDS             complement(5001..6500)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538832"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133600.1"
                     /locus_tag="SAVERM_RS09150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1732"
                     /old_locus_tag="SAVERM_1732"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_010983171.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 9.6e-27, bitscore:
                     92.8, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 7.4e-13, bitscore:
                     47.5, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAEPARAESARAELAVIGAGPAGLAAALAAGARGVRVTLIDSAA
                     QAGGQFYRRPDPALEARRPQVLHHRWRTWERLRDGLAAQVGTGGVKHLTEHQVWLVERQ
                     STGFTVHALRAESPVVVHADAVLLATGGYEKVLPFPGWTLPGVLTAGGAQAMLKGGLAV
                     AGGTAVVAGTGPLLLPVATGLAAAGVEVAALVEAADPKTLVRHARALAVKLPEGARYAA
                     RLLRHRVEFLGRHTVVEAHGGERLAAVTVAALDAGGRVRTGTERRILCDTLAVGHGMLP
                     HTDLAETLGCRVDGLNVSVDEEQRTSVPGVWAAGETTGIGGAALSLAEGHIAGRSIAAR
                     LAGREPDPRAWAAAAKSRTRLRQFAAVLDTVYAPPAHWSDRVTDDTVVCRCEEVTGGAI
                     REAVEELGAGDLRTVKLLTRAGMGWCQGRMCGPAVAGLAGCQLAPSSGPFARPVPLGVL
                     ARAADGHRSEAPTADHGDEAPADGRRAEAPADDHLTQRGPS"
     gene            complement(6490..6789)
                     /db_xref="GeneID:41538833"
                     /locus_tag="SAVERM_RS09155"
                     /old_locus_tag="SAV_1733"
                     /old_locus_tag="SAVERM_1733"
     CDS             complement(6490..6789)
                     /codon_start=1
                     /db_xref="GeneID:41538833"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118955.1"
                     /locus_tag="SAVERM_RS09155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1733"
                     /old_locus_tag="SAVERM_1733"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_010983172.1"
                     /sec_met_domain="Fer2_4 (E-value: 4.9e-26, bitscore: 89.5,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLRLVHARPGAAFAVTFDGREIEALPGQTVAAALWSAGVTAWR
                     TTRGGGRPRGVFCGIGVCFDCLLSVNGAPNQRACLVRVRPGDVIRTQEGTGHEG"
     gene            complement(6786..8033)
                     /db_xref="GeneID:41538834"
                     /locus_tag="SAVERM_RS09160"
                     /old_locus_tag="SAV_1734"
                     /old_locus_tag="SAVERM_1734"
     CDS             complement(6786..8033)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538834"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996369.1"
                     /locus_tag="SAVERM_RS09160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1734"
                     /old_locus_tag="SAVERM_1734"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_010983173.1"
                     /sec_met_domain="DAO (E-value: 1.3e-61, bitscore: 208.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPLTCDVVVVGAGMVGAACAYYAARAGLDVTLVDRGPVAGGTT
                     GAGEGNLLVSDKEPGPELELALLSGRLWAELVERRPGFGHAVEYEAKGGLVVAETPEAL
                     TALTDLAARQSAAGVEVSPAAADQLRELEPHLAPGLAGAVRYPQDAQVMPALAAAHLVR
                     ASGARPATGASVTAVLRTPDGSVRGVRTDRGDIHAPAVVNAAGTWGGEVARLAGVRLPV
                     LPRRGFVLVTEPLPRMIWHKVYAADYVADVASDSAALATSPVVEGTAAGPVLIGASRER
                     VGFDRTFSLPVVRELAAGATRLFPFLVGVHAVRAYVGFRPYLPDHLPAIGPDARVPGLF
                     HACGHEGAGIGLATGTGYLIAQVLAGRDPDLDLTPFRPERFSGHFPDRSQDGLPGALPD
                     RPAHRGADRREDQETP"
     misc_feature    8039..8049
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            complement(8130..8945)
                     /db_xref="GeneID:41538835"
                     /locus_tag="SAVERM_RS09165"
                     /old_locus_tag="SAV_1735"
                     /old_locus_tag="SAVERM_1735"
     CDS             complement(8130..8945)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538835"
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676843.1"
                     /locus_tag="SAVERM_RS09165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1735"
                     /old_locus_tag="SAVERM_1735"
                     /product="ABC transporter permease"
                     /protein_id="WP_037645865.1"
                     /transl_table=11
                     /translation="MQLSRSARIALRVAAGCGFAAIYVPLALVLVNSFNSDRSASWPPS
                     GLTLHWWSVAWGSEGARAALWVSVKAGLGATAIALLLGTLIAFAVARHRFFGRDAISFV
                     VVLPIALPGIVTGIALNSAFSTVLEPLGVGLGMFTVVVGHATFCIVVVFNNVVARLRRT
                     SGSYEEAAMDLGANTFRAFADVTFPLVRSALLAGGLLAFALSFDEIVVTTFTAGPGIET
                     LPIWIFNNMTRPQQAPVVNVVAAVLVLLSVLPIYVAQRLSADTATESRI"
     gene            complement(8968..9861)
                     /db_xref="GeneID:41538836"
                     /locus_tag="SAVERM_RS09170"
                     /old_locus_tag="SAV_1736"
                     /old_locus_tag="SAVERM_1736"
     CDS             complement(8968..9861)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538836"
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568653.1"
                     /locus_tag="SAVERM_RS09170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1736"
                     /old_locus_tag="SAVERM_1736"
                     /product="ABC transporter permease"
                     /protein_id="WP_010983175.1"
                     /transl_table=11
                     /translation="MKTTTARAAGRTPVRRLAGTLHRRPRLRLSLLLTAPLLWLAVLYL
                     GSLSVLFISAFWTTNSFTSEVVKVWSTDNFHTLFTTPVFRQVILRSVGVALAVTVLCAV
                     IAFPVAFYTARLAKPKWRPLLVVAILTPLWASYLVKVYAWRLILSQDGLADWMLKPFGL
                     SGPGFGLPATVITLTYLWLPYMILPIHTALEQLPANLLDASADLGARAGRTFRSVVLPM
                     VLPSVAAGSVFTFSLSLGDYITVQIVGGKTQLIGNLVYSNIELNLPMAAALGTVPVVVI
                     VVYLLAMRRTGALSSL"
     gene            complement(9869..11068)
                     /db_xref="GeneID:41538837"
                     /locus_tag="SAVERM_RS09175"
                     /old_locus_tag="SAV_1737"
                     /old_locus_tag="SAVERM_1737"
     CDS             complement(9869..11068)
                     /codon_start=1
                     /db_xref="GeneID:41538837"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676845.1"
                     /locus_tag="SAVERM_RS09175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1737"
                     /old_locus_tag="SAVERM_1737"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_037646147.1"
                     /transl_table=11
                     /translation="MRLTRTLQATAAVAVLLAATACGSSDSGGSSSSTGLNPPDLKAQS
                     KLGKTEGQVNLVAWAGYVEDGSNDPKTDWVSDFEKQSGCQVNSKVAASSDEMVKLMKTG
                     QYDAVSASGDASLRLIASGDAAPVNTDLVPNYQDVFSGLKKQAWNSVDGTPYGIPHGRG
                     ANLLMYNTQKVKPAPTSWSAVFDDASRYKGHVTAYDSPIYIADAALYLKATKPELKIKD
                     PYALDQKQFDAAVALLKKQNANVGEYWGDYLKEISAFKSGDSVVGTTWQVIANLAADEG
                     AKVKAVVPKEGSTGWSDTWMVSAKAKHPNCAYKWLDWIISPKVNAQVAEYFGEAPANAK
                     ACDETSDKNFCDTFHATEESYWKDTAFWNTPIEQCLDGRTDVKCVPYAKWVQAWTEIKG
                     "
     gene            complement(11139..12176)
                     /db_xref="GeneID:41538838"
                     /locus_tag="SAVERM_RS09180"
                     /old_locus_tag="SAV_1738"
                     /old_locus_tag="SAVERM_1738"
     CDS             complement(11139..12176)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538838"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521682.1"
                     /locus_tag="SAVERM_RS09180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1738"
                     /old_locus_tag="SAVERM_1738"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_010983177.1"
                     /transl_table=11
                     /translation="MEARAIRLQGLRKVFGDTAAVTGVDLEIADGEFFSMLGPSGSGKT
                     TVLRMIAGFESPTAGRIELAGQEVTGLAPFERDVHTVFQDYALFPHMTVEQNVAYGLKV
                     RKVPRVERLARARKALADVRLEAFGTRRPSQLSGGQRQRVALARALVGRPRVLLLDEPL
                     GALDLKLREQMQVELKAIQREVGITFVFVTHDQEEALTMSDRIAVFNRGRIEQVGTPAE
                     IYERPSTPFVASFVGTSNLLSGESAQRIVGAPGTYSIRPEKIRVLGESAHAGDPQYSTA
                     TGTVVEVVYLGDVTRFLVDLDAGGRLTALQQNLETSSADVAAYRGTRVTLQWHRGHTFR
                     VPEAG"
     misc_feature    12204..12217
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.54"
                     /tool="antismash"
     misc_feature    12244..12260
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.79"
                     /tool="antismash"
     misc_feature    complement(12245..12260)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.03"
                     /tool="antismash"
     misc_feature    12476..12489
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.86"
                     /tool="antismash"
ORIGIN
        1 ggaaggactg gtagttctcg acggggacgt tggcgttggc cttcttgacc tgctggtccc
       61 tggcgtcggc ggcgccgctg aacagccggg gttcgggcag gcccacgggg gcgtcgttct
      121 tcttggcgcg ggcgtagtcg ccgaggaagc ccttgccggg ggtgaggaac atgaagtcga
      181 gccacttcag tccggccttg atctgcgcgg gcgtggcctt cttgttgaac atgtagccgt
      241 cgccgccgat gagggtgccc ttgccgccgg gcatgggggc cagggcgagg tccgtgtagg
      301 tgccgccctt ctccttcacc aggatcggga tgttgtcggg tgcggagagg tacatgccga
      361 gcttgccgga gcccatcagc tgctggacgt cgttgatgac gaggagctgc ttgctgccca
      421 tggagttgtc ggtccagcgc atgtcgtgca ggttctggag caccgccttg ccctcggggg
      481 tgtcgacggt ggccttcttg ccgtcggcgc tcaccacgtc gccgccctgc gagtacagct
      541 cggcggtgaa gtgccagccg ccctggttct gcgcgctgta gtccgcgtag ccgacggtgc
      601 cgccgccgag tgcggcgatc ctcttggcgg cggcgcgcac ctcgtcccag gtcgccgggg
      661 gcttgtcggg gtcgagtccg gccttctcga agagcccccg gttgtagatc agccccatcg
      721 agtagccggt gcgcgggacg ccgtagacct tgccgtcgac ggtgtagatg tcgcgcagct
      781 gctgctggac ggtgtcgtag ctcttgaggt ccttgacgta cgaggtgatg tcggcggcct
      841 ggttgacgtc gacgacgtgg gtggcgtcgg tgaagtacgt gtagaagacg tcctccatct
      901 gaccgccggc gagtttggcg tcgaacgtct tggggtcctg gcaggggaag gcgtcatggg
      961 cgacgacgtc gatgtccggg ttcttcttct cgaaggcggc gatgtcgtcc tcgaagaact
     1021 tccggtcgac cttggcgctc ttgggcggca tgcagttcac ggtgatgcgg gtcttgccgt
     1081 cggccgcatc accgctcgaa ccgcacgcgg tcaggacgaa cgaacaggcc acgagcgcga
     1141 cacaggcacg gcggaacccg gagcttctca tcggtggacc ccttttgggc aggagcggtg
     1201 ggcgccctgg gcaggagcgg tgggcgtcgc acactcaagc accgacgaca tcggctcgca
     1261 agatgtcgcg cagaatctgt aattattcga cagacgtgtg gatctccgcg cgttccgtca
     1321 ccgcggggct tgcgcggtgg atccccgcac caccagctcc ggttcgaaca agagctcctc
     1381 gtccggtacg gagctgccgc cgatccgcgc gttcagcagc tccaccaccg cccgccccat
     1441 ggactcgatg ggctggcgaa cggtggtcag cgggggttcc gtgcagttca tgagggccga
     1501 gtcgtcgtag ccgacgacgg agatctggga cggaacgtca agtcccttgc ggcgggcggc
     1561 ccgtaccgcg ccgagcgcca gggggtcgct ggcgcagatg aagccggtga cgccccggtc
     1621 gatgagccgg gaggccgccg cgtggccgcc ctcgatggag aacatggccc gggcgacgta
     1681 ctcgtccggg aggtccccga gagcccgcgc ggccgccagc ttccgcgccg agggcatatg
     1741 gtcacccggc ccgagcacga gtccgatccg ttcgtgtccg agcgaggcga gatgccgcca
     1801 ggcctgctcc accgccacgg cgtcgtcgca ggagacggcc gggaaaccga ggtgctcgat
     1861 ggccgcgttg accagcacca ccgggatgtt gcggtccgcg agccggcggt agtggtcgtg
     1921 cggcgcgtcg gcctgcgcgt acagtccgcc cgcgaacacc acaccggaga cctgctgctg
     1981 gagcagcagg ttcacgtaat ccgcctcgga gacaccgccc ttggtctgcg tgcacagcac
     2041 gggcgtgagg ccgagctggg cgagcgctcc gccgatgacc tcggcgaagg ccgggaagat
     2101 cgggttctgg agctcgggga gcaccagtcc gacgagccgg gcccgctcgc cgcgcagctg
     2161 cgtgggccgc tcgtagccga ggacgtcgag cgccgagagc accgcctgcc gggtggccgg
     2221 ggagactccc ggcttgtcgt tgagcacccg gctgaccgtg gcctcactga ccccgacctt
     2281 cttcgccacc tcagcaagtc gtcgcgtcat gcgcgcaaga atagcgcaag taacgcaagc
     2341 cgtttgcgta gcggtgtcag ggggccaccc agagtccgcg cacatggccg aggtgccggg
     2401 tcgtcacctc gcgcgcggcc tcggtgtcgc gggccagcag cgcgtcgagg agttcgaggt
     2461 gctcctcggc ggaggcccgc agccggcccg cccgggcgag ggcggtgagt ccgtacaggc
     2521 gggagcggcg ccgtaggtcc cgtacgacgt ccacgaggtg gtcgttgccg gcgagcgcga
     2581 gcagccccag gtggaagcgc aggtccgcct cgacgtacgc gatgaggtcc ccggccgtgg
     2641 cggcggcgac gatctcccgc gcgaccgggc gcagcgcctc cagctcggcc gggtcggcgg
     2701 tgagcgcgag gcccgccgtc gtcgggatct cgatcagcga cctgatgtgc gtgtactcgt
     2761 cgagctgttt ctcggagacc gcggtgaccc ggaagccctt gttcgggacg gtgtcgacca
     2821 ggccctcctt cgcgaggtcg agcatggcct cacgcaccgg ggtcgcggag accccgaagc
     2881 gggcggcgag gccgggcgcc gaatagacct ccccggcgcg cagctcaccg gcgatcagcg
     2941 cggcccgcag ggcgtcggcg acccgctccc ggtagctggg cttcctgccg cccagcgtgg
     3001 gcagggcggg gctgtgctgc gcggccatcg cggtcttcct cctcggggcg gggtccccgg
     3061 gcacgggggc cgggtcaccg gacattatcg acgccgccta cagcacgaac cccgccggga
     3121 aggggtcctc ggggtccagc aggtactggg ccgtcccggt gacccaggcg cgcccggtga
     3181 agctgggcag gacggcgggg atgccggcca cctcggtcgt gccgagcagc cggccggtga
     3241 accgggtccc gatgagggac tcgttgacga actcggtgcc gagcggaagt tcaccgcgcg
     3301 cgtgcaactg cgccatacgg gcgctggttc cggtgccgca cggcgagcgg tcgaaccagc
     3361 cgggatggat ggccatcgcg tgccgggagt ggcgggcgtc ggagccgggc gcgacgaggt
     3421 ggacgtggtg gcagccgcgg atggacgggt cctcggggtg gacgggcccg ccgtccgcgt
     3481 tgacggcgtc catcagggac aggcccgcct tgaggatgtc gtccttgcgg gaccggtcga
     3541 agggcagtcc gaactccccc agcggcagga tcgcgtagaa gttcccgccg tacgcgaggt
     3601 cgtacgtcac cgtgcggccg tcggcgagcg tggccttgcg gtcgaggccg acgcagaagg
     3661 acggcacgtt cttgagcgtg acggcccggg cggcgccgtc ctcgaccgcc acctcggcga
     3721 cgacgaggcc cgccggggtg tcgaggcgga tcgtggtgac cggctcgacg acctcgacca
     3781 tgccggtctc cacgagcacg gtcgcgacgc cgatcgtgcc gtggccgcac atcggcagat
     3841 agccggagac ctcgatgtag acgacgccga catcgcagtc ggggcgcgcg ggaggctgga
     3901 ggaccgcgcc gctcatggcc gagtgaccgc gcggctcgtt catcagcaac tgcctgatgt
     3961 cgtcgcggtg ttcacggaag tacaggcgcc gttcgttcat ggtcgcgccg gggatcgtgc
     4021 cgatgccgcc ggtgatcacc cgggtcggca tgccctcggt gtgcgagtcg acggcgtgca
     4081 ggacgagttt gctgcgcatc tgccggcctc cccttacgcg agccccgccg ccacggcctt
     4141 ctccgtggcg gcgcggacgg cggtctcctg ctcgggcagc agcgggacgc gcggcgggcg
     4201 taccgggccg ccgtaccgcc cgacgacgtc catggacatt ttgatggcct gcacgaactc
     4261 gaccctggag tcccagcgca gcagcgggtg cagctgccgg tacagctgtg tggcggtggc
     4321 gaggtcgccg tcgacggccg cgtggtacag ctcgacgctc gccgcgggca gtgcgttcgg
     4381 gtagccggcc acccagccct tggcgcccgc gaccgcgagt tccagcagga cgtcgtccgc
     4441 gccgatcagc agatcgagtt ccggggcgag ttcggccagc cggtaggcgc ggcggacatc
     4501 ccccgagaac tccttgaccg cgtggatgta cccctcgccg tgcagcgcgg cgagcagttc
     4561 gggcacgagg tcgaccttgg tgtcgatggg gttgttgtac gcgacgaccg gcacgcccgc
     4621 cttggcgacc tccgcgtagt gggcgcgtac ggaacgctcg tcggcccggt aggcgttcgg
     4681 cggcagcagc atgaccgccc ggcagccggc gtcccgggcc tgttcggccc agcgccgggc
     4741 ctccgccgat ccgtaggcgg cgaccccggg catcacccgc gcgccgccga cggcggacac
     4801 ggccgtctcg acgaccctgg cgcgctcctc gggggtgagc acctggtact caccgagcga
     4861 gccgttcggc acgactccgt cgcaaccctg ctcgacgagc caggcgcagt gctcggcgaa
     4921 cttgtcgtgg tcgacggcga ggtcggcggt gagcgggagc gcggtggcga cgagcacgcc
     4981 gcgccagggg cggtggacgg tcatgagggt cctctctggg tgaggtgatc gtcggcgggg
     5041 gcctcggctc gacggccgtc cgcgggggcc tcgtccccgt ggtcggcggt gggagcctcg
     5101 ctccggtggc cgtcggcggc ccgggcgagt acgccgagcg gtacgggtcg tgcgaacggc
     5161 ccactggacg gggcgagttg gcatccggcg agtccggcga ccgcgggccc gcacatccgg
     5221 ccctggcacc agcccatccc ggcgcgggtg agcagcttga cggtacgcag gtcaccggcg
     5281 ccgagctcct cgacggcctc ccggatcgca ccgccggtga cctcctcgca gcggcagacg
     5341 acggtgtcgt cggtgacccg gtcgctccag tgggcgggcg gcgcgtacac ggtgtcgagc
     5401 acggcggcga actgccgcag tcgggtacgg gacttggcgg ccgccgccca ggcgcgcggg
     5461 tcgggttcgc ggcccgcgag ccgggcggcg atcgaccgtc cggcgatgtg cccctcggcg
     5521 agcgacagcg cggcgccccc gatgccggtg gtctcgcccg cggcccatac accggggacg
     5581 gaggtgcgct gttcctcgtc gacggagacg ttcagcccgt cgacgcgaca gccgagcgtc
     5641 tcggcgaggt cggtgtgcgg gagcatgccg tgtccgacgg cgagggtgtc gcagaggatg
     5701 cgccgctcgg tgccggtccg tacgcgtccg ccggcatcga gggcggcgac ggtcacggct
     5761 gccagccgct caccgccgtg cgcctcgacg acggtgtgcc ggccgaggaa ctcgacacgg
     5821 tgccgcagga gccgagccgc gtaccgggcg ccttcgggca gcttgaccgc gagagcgcgc
     5881 gcatgccgta cgagcgtctt cgggtccgcc gcctccacca gcgccgcgac ctcgacgccc
     5941 gccgcggcca gcccggtcgc cacgggcagc agcagcggcc cggtgccggc cacgaccgcg
     6001 gtaccgcccg ccaccgcgag gccgcccttg agcatcgcct gcgccccgcc cgcggtcagt
     6061 acgccgggga gggtccagcc gggaaacggc agcaccttct cgtagccgcc ggtggcgagg
     6121 aggacggcgt cggcgtggac gacgaccggg ctctccgcac gaagggcgtg gaccgtgaaa
     6181 cccgtcgact gcctttccac gagccacacc tgatgttcgg tcaggtgctt gactcctcct
     6241 gttccgacct gtgcggcgag cccgtcgcgc agccgttccc aggtccgcca ccgatggtgc
     6301 agaacctgcg gtcgccgcgc ctcgagcgcg gggtcgggcc ggcggtagaa ctgaccgccc
     6361 gcctgggcag ccgagtcgat cagcgtgacg cgcactccgc gcgcgcccgc ggccagggcg
     6421 gcggcgaggc ccgccgggcc cgcgccgatc acggccagct cagccctggc cgattcagcc
     6481 ctggccggct cagccctcat ggccggttcc ctcctgtgtg cggatcacat cgcctggccg
     6541 cacccgtacc aggcaagccc gttggttcgg ggcgccgttg acgctcagca ggcagtcgaa
     6601 gcagacgccg atcccgcaga acaccccacg cggtcggccc ccgccccgag tggtgcgcca
     6661 cgcggtcacg cccgccgacc acagcgcggc ggcgaccgtc tgcccgggaa gcgcctcgat
     6721 ctcgcgcccg tcgaaggtga cggcgaacgc cgcccccggc cgcgcgtgga cgagtctcag
     6781 tggattcacg gcgtctcctg gtcctcgcgg cgatccgcac cgcggtgcgc aggacggtcc
     6841 ggaagagcgc ccggaaggcc gtcctgggaa cggtcgggga agtggccgga aaagcgctcg
     6901 ggccggaacg gcgtcaggtc caggtcgggg tcccggccgg ccagcacctg ggcgatcaag
     6961 tacccggtgc cggtggccag tccgatgccc gcgccctcgt gcccgcaggc atggaagagc
     7021 cccggcacgc gtgcgtccgg gccgatggcc ggcagatggt cgggaaggta cgggcggaag
     7081 cccacgtacg cccgtacggc gtgcaccccc acgaggaacg ggaacagccg ggtcgcgccc
     7141 gcggccagct cccgcacgac cggcagtgag aacgtgcggt cgaagccgac ccgttcacgg
     7201 ctggcaccga tcagtaccgg ccccgccgcc gtgccctcga cgaccggcga ggtcgcgagg
     7261 gccgccgagt cgctcgccac atcggcgaca tagtccgccg cgtacacctt gtgccaaatc
     7321 atccgcggca gcggctcggt gacgaggacg aagccgcgcc ggggcagtac gggcagccgg
     7381 acgcccgcga gccgcgccac ttcgccgccc caggtgccgg cggcgttgac gacggcgggg
     7441 gcgtggatgt cgccccggtc ggtgcgcact ccgcgtacgg aaccgtcggg cgtccgcagc
     7501 acggcggtga cactcgcgcc ggtcgccggc cgggcccccg acgcccggac caggtgggcg
     7561 gcggccagtg ccggcatcac ctgcgcgtcc tgcggatacc gcaccgcacc cgcgaggccc
     7621 ggcgccaagt gcggttccag ttcgcgcagt tggtcggcgg cggcgggact cacctcgacc
     7681 ccggcggccg actgccgggc cgccagatcc gtgagagcgg tcagcgcctc gggcgtctcg
     7741 gcgacgacca gaccgccctt ggcctcgtac tcgacggcat ggccgaaccc cggccgccgt
     7801 tcgacgagtt cggcccacaa ccggcctgag agcaaggcga gttcgagttc cggccccggt
     7861 tccttgtcgg agacgagcag attgccctcg cccgcacccg tggtgccgcc cgccaccgga
     7921 ccccggtcca ccagggtcac gtccagaccc gcccgggccg cgtagtaggc gcaggccgcg
     7981 cccaccatgc ctgccccgac gaccacaaca tcgcaggtca gtggcgaagt cacgccagta
     8041 ctatgtcaca caccacacct gtcgccaagg gtgtcgacgc ccctccgggc agccgacggg
     8101 gacggggacc cgccccaggg cctgtcgccc tagatccggc tctcggtcgc cgtgtccgcg
     8161 gacagccgct gggccacgta gatcgggagt acggagagga ggaccaggac cgccgccacg
     8221 acgttcacca ccggtgcctg ctgcggtcgc gtcatgttgt tgaagatcca gatcggcagg
     8281 gtctcgatgc cgggaccggc cgtgaacgtc gtcaccacga tctcgtcgaa ggagagcgcg
     8341 aaggcgagca gcccgcccgc gagcaacgcc gagcgcacca gcgggaaggt gacgtcggcg
     8401 aaggcgcgga aggtgttcgc acccaggtcc atcgccgcct cctcgtacga gccggaggtg
     8461 cggcgcagcc gggcgacgac gttgttgaag acgacgacga tgcagaaggt ggcgtggccg
     8521 acgaccacgg tgaacatgcc gagtccgacg cccaggggct ccaggaccgt actgaacgcc
     8581 gagttgagcg cgatgcccgt gacgatgccg ggcagcgcga tcggcaggac gaccacgaag
     8641 gagatggcgt cgcggccgaa gaagcggtgc cgggccaccg cgaaggcgat gagtgtgccc
     8701 agcagcaggg cgatggccgt ggcgccgagg cccgccttga ccgacaccca caacgcggcg
     8761 cgggcgccct cgctccccca ggcgaccgac caccagtgga gggtcaggcc cgacggcggc
     8821 cagctcgcgc tgcggtcgga gttgaaggag ttgacgagga cgagcgcgag cgggacgtag
     8881 atggccgcga agccgcatcc ggcggcgacg cgcaacgcga tgcgcgcgga acgggacagt
     8941 tgcacggcag ggctcctaac gggctgatca gaggctgctg agcgcacccg tgcggcgcat
     9001 cgcgagcaga tagaccacga tgacgacgac ggggaccgtg ccgagtgcgg cggccatggg
     9061 caggttcagt tcgatgttgg agtagacgag gttgccgatc agctgggtct tgccgccgac
     9121 gatctgcacg gtgatgtagt caccgagact gagcgagaag gtgaagaccg agccggccgc
     9181 gaccgacggc aggaccatcg gcagcacgac cgagcggaag gtgcggccgg cccgcgcgcc
     9241 cagatcggcg gatgcgtcga ggaggttggc gggcagctgc tccagcgccg tgtggatcgg
     9301 caggatcatg tacggcagcc agaggtacgt cagggtgatg accgtcgccg gcaggccgaa
     9361 ccccggaccg ctgagcccga acggcttcag catccagtcg gcgagcccgt cctgggagag
     9421 gatgagccgc caggcgtaca ccttgaccag gtagctggcc cacagcgggg tgaggatcgc
     9481 gaccacgagg agcggacgcc acttcggctt ggccaggcgg gccgtgtaga aggcgaccgg
     9541 gaaggcgatc accgcgcaca ggacggtgac cgcgagcgcg acgccgacgc tgcgcaggat
     9601 cacctggcgg aagacggggg tggtgaacag cgtgtggaag ttgtcggtcg accagacctt
     9661 cacgacctcg gaggtgaagg agttcgtcgt ccagaacgcg gagatgaaca gcacgctcag
     9721 cgagccgaga tagagcacgg cgagccagag cagcggtgcg gtcaggagca gggacagcct
     9781 gagccggggg cggcggtgca gggtcccggc gagccgccgg acgggggtcc gtccggcggc
     9841 tcgcgcagtg gtggtcttca ccgttgtctc agcccttgat ctcggtccag gcctggaccc
     9901 acttggcgta gggcacgcac ttcacgtcgg tacggccgtc gaggcactgc tcgatgggcg
     9961 tgttccagaa ggcggtgtcc ttccagtagc tctcttcggt ggcgtggaag gtgtcgcaga
    10021 agttcttgtc gctggtctcg tcgcaggcct tggcgttggc cggagcctca ccgaagtact
    10081 cggcgacctg ggcgttgacc ttcggtgaga tgatccagtc cagccacttg taggcgcagt
    10141 tggggtgctt ggccttggcg gagaccatcc aggtgtcgga ccagccggtg gagccctcct
    10201 tcggcacgac cgccttgacc ttggcgccct cgtcggcggc gaggttggcg atgacctgcc
    10261 aggtggtgcc gaccacggag tcgccgctct tgaaggcgga gatctccttg aggtagtcgc
    10321 cccagtactc gccgacgttc gcgttctgct tcttcagcag ggcgacggcc gcgtcgaact
    10381 gcttctggtc gagcgcgtag gggtccttga tcttcagttc gggcttggtg gccttgagat
    10441 agagcgccgc gtcggcgatg tagatcgggg agtcgtacgc cgtgacatga cccttgtacc
    10501 gcgaggcgtc gtcgaagacg gcggaccagg aggtcggggc gggcttcacc ttctgcgtgt
    10561 tgtacatcag caggttggcg ccacggccgt gcgggatgcc gtagggcgtg ccgtcgacgg
    10621 agttccacgc ctgcttcttc aggccgctga agacgtcctg gtagttggga acgaggtccg
    10681 tgttgacggg agccgcgtca ccggaggcga tgaggcgcag ggaggcgtcg ccggacgcgg
    10741 acacggcgtc gtactggccg gtcttcatca gcttgaccat ctcgtcggag ctggccgcga
    10801 ccttggagtt gacctggcag ccggactgct tctcgaagtc gctgacccag tcggtcttgg
    10861 ggtcgttgga gccgtcctcg acgtagccgg cccaggcgac gaggttgacc tggccctccg
    10921 tcttgccgag cttcgactgc gccttgaggt cgggcgggtt gaggcccgtc gacgaggacg
    10981 agccgcccga gtcggacgat ccacaggcgg tggccgcgag gagcaccgcg acggcggcgg
    11041 tggcctggag ggttcgggtg agacgcacga cgttctccat acgtgacggg ggactgagcg
    11101 gtggggtcaa cacgtgacgg caggggtgag cggtcgggtc aaccggcttc ggggaccctg
    11161 aaggtgtggc cgcggtgcca ctggagggtg acccgggtgc cgcgatacgc ggcgacgtcc
    11221 gcggaggagg tctccaggtt ctgctggagg gcggtgagcc ggccgcccgc gtccaggtcc
    11281 accaggaaac gggtgacgtc tccgagatag accacctcga cgacggtgcc agtggcggtg
    11341 gagtactgcg ggtcgcccgc gtgggcggac tccccaagga cccggatctt ctcgggcctg
    11401 atgctgtacg tgccgggggc gccgacgatc cgctgtgccg actcgcccga caggaggttc
    11461 gaggtgccga cgaacgaggc cacgaacggg gtcgaggggc gctcgtagat ctcggccggg
    11521 gtgccgacct gttcgatgcg gccccggttg aagacggcga tgcggtcgct catcgtcagg
    11581 gcctcctcct ggtcgtgggt gacgaacacg aaggtgatgc cgacctcgcg ctggatcgcc
    11641 ttgagttcga cctgcatctg ctcgcgcagt ttgaggtcga gggcgccgag cggttcgtcg
    11701 agcagcagca cacgggggcg gccgaccagg gcgcgggcga gcgcgacccg ctggcgctga
    11761 ccgccggaga gctgggatgg gcgccgggtg ccgaacgctt cgaggcgtac gtcggcgagt
    11821 gccttgcggg cccgggcgag ccgctcgacc ctgggcacct tgcggacctt gaggccgtag
    11881 gcgacgttct gttccacggt catgtgcggg aacagggcgt agtcctggaa gacggtgtgc
    11941 acgtcccgtt cgaagggggc gagcccggtg acctcctggc ccgccagctc tatccggccg
    12001 gcggtggggc tctcgaagcc cgcgatcata cgcaggacgg tcgtcttgcc ggagccggac
    12061 gggccgagca tcgagaagaa ctctccgtcg gctatctcca ggtcgacgcc ggtcacggcg
    12121 gcggtatcac cgaacacctt ccgcagtccc tgcagccgga tcgcgcgtgc ctccatgggc
    12181 gggaaccttt ctggtgcact cttacgttaa acgaaaagat atgaagtcat agttcaaagc
    12241 tcaagacccc cttagggtaa aggttgagtc aacgcacaag gtggtggccg tgaagcagcc
    12301 cgtcaacagg aacgccggcg gcgcccggag cgccgtcttc accccggtgg acagccgggc
    12361 acgagtggag acggtcgtcc gccggctcgg cgacgccatc gagctcgggc tgctcgccga
    12421 cggggagcag ctgcccggcg agagcgagct ggccgggcag ctcggcgtgt ccaccgtgac
    12481 cctgcgggaa gcgctcatgg cgctgcggca gcaggggctc gtcaccaccc gcaggggacg
    12541 cggcggcggc agcttcgtct cgctgcccgc gatccccggc gaggagcggc tcagggtgcg
    12601 gctggccggc tggagcacgg aggagctccg ggacctgggc gaccactggg cggccgtgtc
    12661 gggcgcggcg gcccggctcg cggcgcagcg cacggagccg gacgacctcc agcaactgcg
    12721 ccgcacgctc gaggagttcg atcaggccga ggacgcggcg gcgcgcagcc gcgtctacgg
    12781 ccggttccat gtggagttgg ccgcggccgc gcagtccgcc cggctcaccc gcgagcaggt
    12841 cgcgctgcag acggaggtcg gggcgctgct gtgtctcgta ctcggggacg acgcctaccg
    12901 tcaggaagtc gccggccgtc accgcgccgt gatctcggcg gtgcaggatg gggccgacga
    12961 cacggccaga gcactggccg agcggtgtgt acaggactcc acggcgcggc tcatcacgct
    13021 gcgcctcgcc ctg
//
