LOCUS       NC_003155              26656 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2010190
            Orig. end                         :: 2036846
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26656
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="11"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26656
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26656
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16656](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16656)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(374..387)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    complement(430..445)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.01"
                     /tool="antismash"
     misc_feature    1978..1993
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            2133..2930
                     /db_xref="GeneID:41538742"
                     /locus_tag="SAVERM_RS08700"
                     /old_locus_tag="SAV_1642"
                     /old_locus_tag="SAVERM_1642"
     CDS             2133..2930
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069689.1"
                     /locus_tag="SAVERM_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1642"
                     /old_locus_tag="SAVERM_1642"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_010983081.1"
                     /transl_table=11
                     /translation="MTQQVPSTEPELAGVRNFRDVGGLPTVDGRRVRHGLLYRSGHLAH
                     ATDEDAAFLASLDLHTIFDFRNAADIGLEGPDVELPGVRNLNFPLTDPAHGAEFWTMVR
                     DGDLDQLRGLLADGKAANRMITSYRTIIKERTAEHGRVLRELAEESVPALMHCAAGKDR
                     AGLSIAVALLAVGVERDAIVADYLESNAPHRRYKVRRSSSAAQAYSPEVMELLSPLFEA
                     RAEYLAAAFETIEETWGDTDTYLERGLKITPELRERLRERLLD"
     gene            complement(2956..3066)
                     /db_xref="GeneID:41538743"
                     /locus_tag="SAVERM_RS08705"
                     /old_locus_tag="SAV_1643"
                     /old_locus_tag="SAVERM_1643"
     CDS             complement(2956..3066)
                     /codon_start=1
                     /db_xref="GeneID:41538743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494120.1"
                     /locus_tag="SAVERM_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1643"
                     /old_locus_tag="SAVERM_1643"
                     /product="DUF6126 family protein"
                     /protein_id="WP_037646182.1"
                     /transl_table=11
                     /translation="MEEKFPRALWVRLIIYIAVGHLFAGFIYLLFELGAK"
     gene            complement(3102..3728)
                     /db_xref="GeneID:41538744"
                     /locus_tag="SAVERM_RS08710"
                     /old_locus_tag="SAV_1644"
                     /old_locus_tag="SAVERM_1644"
     CDS             complement(3102..3728)
                     /codon_start=1
                     /db_xref="GeneID:41538744"
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656365.1"
                     /locus_tag="SAVERM_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1644"
                     /old_locus_tag="SAVERM_1644"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_010983083.1"
                     /transl_table=11
                     /translation="MSSSESGPVEDLPAVAPQLRALRRRASLTLEVAARAAGLSPAHLS
                     RLETGQRQPSLPMLLALARIYGTTVSELLGETVGDRDAVVRAADMEPAGAGGWTYWQAG
                     AGGRAMQALRVHVPYGTQGDVVRVHPGEEWLYVLKGRLRLRLGDTTHLLGPGDSAHFDS
                     LTPHRLAAADHDGAELLFLHTLLQSPAATLCLGPATGHPTMGDTP"
     misc_feature    complement(3734..3754)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            complement(3816..5246)
                     /db_xref="GeneID:41538745"
                     /locus_tag="SAVERM_RS08715"
                     /old_locus_tag="SAV_1645"
                     /old_locus_tag="SAVERM_1645"
     CDS             complement(3816..5246)
                     /NRPS_PKS="Domain: Aminotran_3 (56-378). E-value: 6.9e-90.
                     Score: 293.4. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS08715_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GeneID:41538745"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139901.1"
                     /locus_tag="SAVERM_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1645"
                     /old_locus_tag="SAVERM_1645"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_010983084.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.9e-87, bitscore:
                     292.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPSGKAPSEGAPSGNREFDLGALLAERGAERYELHAKYLNHQL
                     PRMLHTIGFDKVYERAEGAHFWDADGKDYLDMLAGFGVMGLGRHHPVVRKALHDVLDAS
                     LADLTRFDCQPLPGLLAEKLLTHSPHLDRVFFGNSGTEAVETALKFARYATGKPRILYC
                     SHAFHGLTTGSLSVNGEDGFRDGFAPLLPDTAVPLGDLDALARELKKGDVAALIVEPIQ
                     GKGVHEAPPGHLRAAQDLLQRHKALLIADEVQTGLGRTGDFYAYQHEEGVEPDLVCVAK
                     ALSGGYVPVGATLGKEWIFKKVYSSMDRVLVHSASFGSNAQAMAAGLAVLSVMENEQIV
                     ANARATGEQLKSRLAALVDTYELLSDVRGRGLMIGIEFGRPTSLKLRSRWTVLQAARKG
                     LFAQMVVVPLLQRHRILTQVSGDHLEVIKLIPPLIIDERDVDRFVAAFTAVMDDAHSGG
                     GLLWDFGKTLVKQAVAQR"
     aSDomain        complement(4113..5078)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS08715_Aminotran_3.1"
                     /evalue="6.90E-90"
                     /label="SAVERM_RS08715_Aminotran_3.1"
                     /locus_tag="SAVERM_RS08715"
                     /protein_end="378"
                     /protein_start="56"
                     /score="293.4"
                     /tool="antismash"
                     /translation="VYERAEGAHFWDADGKDYLDMLAGFGVMGLGRHHPVVRKALHDVL
                     DASLADLTRFDCQPLPGLLAEKLLTHSPHLDRVFFGNSGTEAVETALKFARYATGKPRI
                     LYCSHAFHGLTTGSLSVNGEDGFRDGFAPLLPDTAVPLGDLDALARELKKGDVAALIVE
                     PIQGKGVHEAPPGHLRAAQDLLQRHKALLIADEVQTGLGRTGDFYAYQHEEGVEPDLVC
                     VAKALSGGYVPVGATLGKEWIFKKVYSSMDRVLVHSASFGSNAQAMAAGLAVLSVMENE
                     QIVANARATGEQLKSRLAALVDTYELLSDVRGRGLMIGIEF"
     gene            complement(5243..7141)
                     /db_xref="GeneID:41538746"
                     /gene="dxs"
                     /locus_tag="SAVERM_RS08720"
                     /old_locus_tag="SAV_1646"
                     /old_locus_tag="SAVERM_1646"
     CDS             complement(5243..7141)
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538746"
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044657.1"
                     /locus_tag="SAVERM_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1646"
                     /old_locus_tag="SAVERM_1646"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_010983085.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.6e-111,
                     bitscore: 370.1, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-05, bitscore:
                     24.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMLENIRGPRDLKALSEAELGELAEEIREFLVHAVARTGGHLGP
                     NLGVVELSVALHRAFESPVDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREE
                     SEHDVIENSHASTVLGWADGLAKARQVQGEKGHVVAVIGDGALTGGMAWEALNNIAAAK
                     DRPLIIVVNDNERSYSPTIGGLANHLATLRTTDSYEKVLAWGKDVLLRTPVVGNTLYES
                     LHGAKKGFKDAFAPQGMFEDLGLKYVGPIDGHDMKAMESAFRRAKRFHGPVLIHCLTEK
                     GRGYEPALAHDEDRFHTVGVMDPLTCEPLAPSNGPSWTSVFGDEIVRIGEEREDVVAIT
                     AAMLHPVGLNKFAEKFPGRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQ
                     LLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSILQVVPGLRIAAPRDADQLRAQL
                     REAVAVDDAPTLLRFPKESVGPAIPAVDHVGGMDVLHRFPESPQVLLVAVGVMAPVCLQ
                     AAELLEARGIGCTVVDPRWVKPVDPSLPGLAAEHRLVAVVEDNSRAAGVGAAVALALSD
                     AEVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVEIAGRISAGLATKEELSKEKQE"
     gene            complement(7170..8327)
                     /db_xref="GeneID:41538747"
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="SAVERM_RS08725"
                     /old_locus_tag="SAV_1647"
                     /old_locus_tag="SAVERM_1647"
     CDS             complement(7170..8327)
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538747"
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031167.1"
                     /locus_tag="SAVERM_RS08725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1647"
                     /old_locus_tag="SAVERM_1647"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_010983086.1"
                     /transl_table=11
                     /translation="MTAISLGVPEVPVRPIAERRVSRQIQVGPLAVGGTAPVSVQSMTT
                     TRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALAVIARKSQIPVVADIHFQPKYV
                     FAAIEAGCAAVRVNPGNIKQFDDKVKEIARAAKEHGTPIRIGVNAGSLDRRLLEKYGKA
                     TPEALVESALWEASLFEEHDFRDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVTEAG
                     PAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPVEEIKVGIQILESLGLRQRRLEIVSC
                     PSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQI
                     FVKGEVIKTVPESKIVETLIEEAMKIAEQMEQNGVASGEPAVTVS"
     gene            complement(8332..9354)
                     /db_xref="GeneID:41538748"
                     /gene="hpnH"
                     /locus_tag="SAVERM_RS08730"
                     /old_locus_tag="SAV_1648"
                     /old_locus_tag="SAVERM_1648"
     CDS             complement(8332..9354)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538748"
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980252.1"
                     /locus_tag="SAVERM_RS08730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1648"
                     /old_locus_tag="SAVERM_1648"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_010983087.1"
                     /sec_met_domain="PF04055 (E-value: 4.5e-16, bitscore: 58.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 6.9e-09, bitscore: 34.3,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQTIKVATYLAEQKLRKREKFPLIVELEPLFACNLKCEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVARKKYVF
                     LCTNAMLLRKKMVDFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF
                     RVTTNSTFFNTDTPQTIIEVLNFLNDDLEVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FRKAFAGGNRRRWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQKPCYLMSDGYVT
                     TYRELIEDTDWDAYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAARETVSGNRG
                     "
     gene            complement(9360..10001)
                     /db_xref="GeneID:41538749"
                     /locus_tag="SAVERM_RS08735"
                     /old_locus_tag="SAV_1649"
                     /old_locus_tag="SAVERM_1649"
     CDS             complement(9360..10001)
                     /codon_start=1
                     /db_xref="GeneID:41538749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431357.1"
                     /locus_tag="SAVERM_RS08735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1649"
                     /old_locus_tag="SAVERM_1649"
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_037645889.1"
                     /transl_table=11
                     /translation="MSTKPDPAPLLIACALGIERLALRSGDRGGADGPVTVLRTGMGPK
                     AAERAVTRVLADPALREAAVVATGFCAGLAPGMHPGDLVVAEETRDPRGVTPCVGTEVL
                     VKELVRAVPGRTVHTGPLIGSDHVVRGHERSDLLLTGAIAADMESASTLHGAVCTGTRP
                     VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRAVLPAFFEWHRSLLLPRR"
     gene            complement(10001..12001)
                     /db_xref="GeneID:41538750"
                     /gene="shc"
                     /locus_tag="SAVERM_RS08740"
                     /old_locus_tag="SAV_1650"
                     /old_locus_tag="SAVERM_1650"
     CDS             complement(10001..12001)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538750"
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656371.1"
                     /locus_tag="SAVERM_RS08740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1650"
                     /old_locus_tag="SAVERM_1650"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_010983089.1"
                     /sec_met_domain="T2TS (E-value: 8e-151, bitscore: 502.1,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSTGALPPRAASASEPHDTIPQAAGSVGIQDAAARATQR
                     ATDFLLSRQDAEGWWKGDLETNVTMDAEDLLLRQFLGIQDEKTTRAAGLFIRGEQRADG
                     TWATFYGGPGDLSATIEAYVALRLAGDGPDEPHMAKASAWIRERGGIASARVFTRIWLA
                     LFGWWKWDDLPELPPELIYFPKWMPLNIYDFGCWARQTIVPLTVVSAKRPVRPAPFPLD
                     ELHADANDPNPAKPLAPMVSWDGLFQRLDVALHTYRKVAPRRLRKAAMNTAARWIIERQ
                     ENDGCWGGIQPPAVYSVIALYLLGYDLEHPVMREGLASLDRFAVWRDDGARMIEACQSP
                     VWDTCLATIALADAGVPADHPQLVRAADWMLGEEIVRPGDWAVKRPQLPPGGWAFEFHN
                     DNYPDIDDTAEVVLALRRVKHHDPERLDNAIRRGVRWNLGMQSKDGGWGAFDVDNTSPF
                     PNRLPFCDFGEVIDPPSADVTAHVVEMLAFEGLSHDPRTRRGIQWLLSAQEANGSWFGR
                     WGVNYVYGTGSVVPALVAAGLPASHPAIRRAVTWLETVQNDDGGWGEDLRSYPEAAEWS
                     GKGASTASQTGWALLALLAAGERESKAVERGIEWLAQTQRPDGSWDEPYFTGTGFPWDF
                     SINYHLYRQVFPLTALGRYVNGEPLVEVKGG"
     misc_feature    complement(11264..11266)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12105..12120
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    complement(12108..12123)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            complement(12116..13246)
                     /db_xref="GeneID:41538751"
                     /locus_tag="SAVERM_RS08745"
                     /old_locus_tag="SAV_1651"
                     /old_locus_tag="SAVERM_1651"
     CDS             complement(12116..13246)
                     /codon_start=1
                     /db_xref="GeneID:41538751"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386166.1"
                     /locus_tag="SAVERM_RS08745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1651"
                     /old_locus_tag="SAVERM_1651"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_010983090.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.5e-59, bitscore:
                     198.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPDLHGTGPRTPRTATRGETVPTVPPAEKAADAVDVTALLERGR
                     TLSTPVLRAAVDRLAPPMDTVAAYHFGWIDAAGNPADGDGGKAVRPALAVLSAQAAGAA
                     PEVGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANE
                     ILLELGTVEAGRATRRLTTASRALIDGQAQDISYEHRERVTVEECLEMEGNKTGALLAC
                     ACSIGAVLGGADDRTADTLEKYGYHLGLAFQAVDDLLGIWGDPESTGKQTWSDLRQRKK
                     SLPVVAALAAGGPASRRLGELLAEDAKSSDFENFSEEEFAARAALIEEAGGREWTAQEA
                     RRQHTIAIEALDTIEMPQQVRAQLVALADFVVVRKR"
     gene            complement(13243..14670)
                     /db_xref="GeneID:41538752"
                     /gene="hpnE"
                     /locus_tag="SAVERM_RS08750"
                     /old_locus_tag="SAV_1652"
                     /old_locus_tag="SAVERM_1652"
     CDS             complement(13243..14670)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538752"
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983091.1"
                     /locus_tag="SAVERM_RS08750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1652"
                     /old_locus_tag="SAVERM_1652"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_010983091.1"
                     /transl_table=11
                     /translation="MSDATRLEGPDAEASGRPERAAVVVGGGLAGITAALALADAGVRV
                     TLLEGRPRLGGLAFSFQRGALTVDNGQHVYLRCCTAYRWFLDRIDAASLAPLQDRLDVP
                     VLDAGGKPGRRLGRIGRTALPVPLHLAKSLATYPHLSLAERARVGRAALALKGLDLADP
                     ALDTQNFGSWLAAHGQSARAVEALWDLVGVATLNAVAGDSSLGLAAMVFKTGLLSDPGA
                     ADIGWARVPLGELHDRLARKALDSVGVRTEVRTRVTSISLNGNGRWSVQVPGETLHADA
                     VVLAVPQREAHELLPEGALDAPERLLEIGTAPILNVHVVYDRKVLSRPFFAALGSPVQW
                     VFDRTEASGLPEGQYLALSQSAAQDEIDEPVSVLRERYLPELERLLPATRGAQVKDFFV
                     TRERTATFAPTPGVGRLRPGARTKAPGLCLAGAWTATGWPATMESAVRSGVSAAGAALN
                     ALGRPRDHLLELFEEAA"
     gene            complement(14667..14807)
                     /db_xref="GeneID:91294818"
                     /locus_tag="SAVERM_RS44605"
     CDS             complement(14667..14807)
                     /codon_start=1
                     /db_xref="GeneID:91294818"
                     /inference="COORDINATES: protein motif:HMM:NF039420.3"
                     /locus_tag="SAVERM_RS44605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6380 family protein"
                     /protein_id="WP_237528744.1"
                     /transl_table=11
                     /translation="MDNVGQGDSSGEKRHATLRWCTASLTATACRAPFKHRGGPAGEDA
                     R"
     gene            complement(14807..15757)
                     /db_xref="GeneID:41538753"
                     /gene="hpnD"
                     /locus_tag="SAVERM_RS08755"
                     /old_locus_tag="SAV_1653"
                     /old_locus_tag="SAVERM_1653"
     CDS             complement(14807..15757)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538753"
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994383.1"
                     /locus_tag="SAVERM_RS08755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1653"
                     /old_locus_tag="SAVERM_1653"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_010983092.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.4e-55, bitscore:
                     185.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 9.4e-69,
                     bitscore: 230.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTVESEQHVSAPVLAAYSYCETVTGQQARNFAYGIRLLPTPKR
                     RAMSAVYAFSRRVDDIGDGALAPDVKAARLEDTRALLSRVRDGRVDEDDTDPVAVALAH
                     AAEQFPIPLGGLDELIDGVLMDVRGETYETWDDLKVYCRCVAGAIGRVSLGVFGTEPGA
                     RGAERASEYADTLGLALQLTNILRDVREDAEGGRTYLPADDLAKFGCSAGFDRPIPPEG
                     SDFAGLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIEREPEAVLR
                     GRVSLPGREKAYVAVRGLSGLDARHVSRRTVRRRV"
     gene            complement(15754..16656)
                     /db_xref="GeneID:41538754"
                     /gene="hpnC"
                     /locus_tag="SAVERM_RS08760"
                     /old_locus_tag="SAV_1654"
                     /old_locus_tag="SAVERM_1654"
     CDS             complement(15754..16656)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538754"
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042802.1"
                     /locus_tag="SAVERM_RS08760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1654"
                     /old_locus_tag="SAVERM_1654"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_010983093.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.9e-38, bitscore:
                     131.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 9.8e-40,
                     bitscore: 135.5, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEAGTARAADPERDTLDKAADENFPVAPFFLPRAWRTDLMAVYG
                     FARLVDDIGDGDLAPGGADARLLGVSPREAEDRLALLDAFEADLHRVFDSTPRHPLLRR
                     LQPTVRRTGLSPEPFLGLIAANRQDQLVTRYETYDDLVAYCELSANPVGHLVLGVTGTS
                     TPERVRRSDAICTALQIVEHLQDVSEDLGRDRVYLPAEDMKRFHVQEADLATATAGASV
                     RALVAYETERALNLLNEGTPLVGSVHGRLRLLLAGFVAGGRAAIRAIAAAEYDVLPGPP
                     KPGKLQLLREVGVTLRGEG"
     misc_feature    complement(16787..16800)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.92"
                     /tool="antismash"
     gene            complement(17017..17796)
                     /db_xref="GeneID:41538755"
                     /locus_tag="SAVERM_RS08765"
                     /old_locus_tag="SAV_1655"
                     /old_locus_tag="SAVERM_1655"
     CDS             complement(17017..17796)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538755"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330378.1"
                     /locus_tag="SAVERM_RS08765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1655"
                     /old_locus_tag="SAVERM_1655"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_010983094.1"
                     /transl_table=11
                     /translation="MAEQRNDSHIPTVIADELHIVYRVNGAKTGKGSATAALSRIVKRG
                     EERGVRKVHAVKGVSFTAYRGEAIGLIGSNGSGKSTLLRAIAGLLPAEKGKVYTDGQPS
                     LLGVNAALMNDLTGERNVILGGLAMGMSREQIRERYQEIVDFSGINEKGDFITLPMRTY
                     SSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQKRSEARIRELRKEAGTVFLVSHNN
                     KSIRDTCDRVLWLERGELRMDGPTEEVLKEYEKFTGK"
     gene            complement(17789..18718)
                     /db_xref="GeneID:41538756"
                     /locus_tag="SAVERM_RS08770"
                     /old_locus_tag="SAV_1656"
                     /old_locus_tag="SAVERM_1656"
     CDS             complement(17789..18718)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964854.1"
                     /locus_tag="SAVERM_RS08770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1656"
                     /old_locus_tag="SAVERM_1656"
                     /product="ABC transporter permease"
                     /protein_id="WP_010983095.1"
                     /transl_table=11
                     /translation="MSETTHDGGVAVSARPSPDEGLSGAELAAKYGLAVSGARPGLVEY
                     VRQLLGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNAAVYYLIFGLILHASKGMP
                     SDVYIPFLVTGVFVFTFTQSSVMAGVRAISGNLGLVRALHFPRAALPISFSLQQLQQLL
                     FSMIVLFLVAIGFGSYPSLSWVLIVPVLALQFLFNTGLALIMARMGAKTPDLAQLMPFV
                     MRTWMYASGVMFSIPVMLADKPAWVADVLQWNPAAIYMDLMRFALIDGYGSENLPPHVW
                     AVAAGWAVLVALGGFVYFWKAEERYGRG"
     gene            complement(18816..19700)
                     /db_xref="GeneID:41538757"
                     /locus_tag="SAVERM_RS08775"
                     /old_locus_tag="SAV_1657"
                     /old_locus_tag="SAVERM_1657"
     CDS             complement(18816..19700)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /db_xref="GeneID:41538757"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983096.1"
                     /locus_tag="SAVERM_RS08775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1657"
                     /old_locus_tag="SAVERM_1657"
                     /product="glycosyltransferase"
                     /protein_id="WP_010983096.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.7e-12,
                     bitscore: 45.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATKVGAVIITMGNRPDELRALLDSVAKQDGDRVEVVVVGNGS
                     PVPDVPAGVRTVELPENLGIPGGRNVGIEAFGPGGTDVDILLFLDDDGLLAHHDTAELC
                     RQAFTADPELGIISFRIADPDTGETQRRHVPRLRASDPMRSSRVTTFLGGANAVRTKVL
                     AEVGGLPDEFFYAHEETDLAWRALDAGWMIDYRSDMVLYHPTTAPSRHAVYHRMVARNR
                     VWLARRNLPAPLVPVYLGVWLLLTLARRPSGPALKAWFGGFKEGWTSPCGPRRPMKWRT
                     VWRLTRLGRPPVI"
     gene            complement(19697..20476)
                     /db_xref="GeneID:41538758"
                     /locus_tag="SAVERM_RS08780"
                     /old_locus_tag="SAV_1658"
                     /old_locus_tag="SAVERM_1658"
     CDS             complement(19697..20476)
                     /codon_start=1
                     /db_xref="GeneID:41538758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049651.1"
                     /locus_tag="SAVERM_RS08780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1658"
                     /old_locus_tag="SAVERM_1658"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_042492878.1"
                     /transl_table=11
                     /translation="MQKPSVAELRPVVHPPGVKDRRSGEHWAGRLYMRELSLRIDRHLV
                     NTRITPNQLTYVMTVAGVLAAPALLVPGITGAVLGVVMVQLYLLLDCVDGEVARWKQQF
                     SLGGVYLDRVGAYLCDAAVLVGFGLRAADLWGSGRIDWLWAFLGTLAALGAILIKAETD
                     LVGVARHQGGLPPVKEAASEPRSSGMALARKAAAALKFHRLVLGVEASLLILVLAILDS
                     IRGDLYFSRLGVAVLAGIALLQTLLHLVSILASSRLK"
     gene            complement(20454..21515)
                     /db_xref="GeneID:41538759"
                     /locus_tag="SAVERM_RS08785"
                     /old_locus_tag="SAV_1659"
                     /old_locus_tag="SAVERM_1659"
     CDS             complement(20454..21515)
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538759"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494151.1"
                     /locus_tag="SAVERM_RS08785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1659"
                     /old_locus_tag="SAVERM_1659"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_010983098.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.7e-20, bitscore: 72.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDIRPGALDDLASVLADQRISHSGKLAVAISG
                     GSGAKLRERLAPALPGATWYEVGGGTLDDAIKLADDMKSGHYDAVVGLGGGKIIDCAKF
                     AAARIGLPLVAVATNLSHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIREAPVRF
                     VRSGIGDALSNISAVRDWELAHREKGEQIDGLAAAMARQAGEAVLRHPGGVGDDSFLQV
                     LAEGLVLTGISMSVAGDSRPASGACHEINHAFDLLFPKRAASHGEQCGMGAAFAMHLRG
                     AHEESGYMAEVLHRHGLPVLPDEIGFTVDEFVQVVEFAPQTRPGRYTILEHLDLNTEQI
                     RDAYADYAKAIGS"
     gene            complement(21503..22255)
                     /db_xref="GeneID:41538760"
                     /locus_tag="SAVERM_RS08790"
                     /old_locus_tag="SAV_1660"
                     /old_locus_tag="SAVERM_1660"
     CDS             complement(21503..22255)
                     /codon_start=1
                     /db_xref="GeneID:41538760"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="SAVERM_RS08790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1660"
                     /old_locus_tag="SAVERM_1660"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_010983099.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.1e-09, bitscore:
                     36.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGNEDSLTVLDLTLG
                     NFAEIGLTEVAVIVGYRKEAVYERREALEAKYGLKITLIDNDKAEEWNNAYSLWCGRDA
                     IKHSVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKSLADEEMKVVVGPEGGMTK
                     ITKLMDPAEATGEYIGVTLIEGEAADELADALKTVFETDPQQFYEHGYQELVNRGFRID
                     VAPIGDVKWVEIDNHEDLAKGREIACQY"
     gene            complement(22252..24051)
                     /db_xref="GeneID:41538761"
                     /locus_tag="SAVERM_RS08795"
                     /old_locus_tag="SAV_1661"
                     /old_locus_tag="SAVERM_1661"
     CDS             complement(22252..24051)
                     /codon_start=1
                     /db_xref="GeneID:41538761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996269.1"
                     /locus_tag="SAVERM_RS08795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1661"
                     /old_locus_tag="SAVERM_1661"
                     /product="DUF5941 domain-containing protein"
                     /protein_id="WP_037645886.1"
                     /transl_table=11
                     /translation="MSTAILTGQPVPGSSLEGDLRSLGFDVRVASDAGDAETLLAAVPA
                     NQRVAIVDARFVGHLHALRLGLTDPRFEAAALAGAVSAQPGARQALTRALARESSAATG
                     GATVVMDNLAERITAALDADGVQVHRPDLGTLVAAVPADPQARNEVRQAVTAVDDEAVR
                     LRTAVKSRDGFFTTHFISPYSRYLARWCARRGLTPNQVTTASLLTALVAAGCAATGTRA
                     GFVAAGLLLLFSFVLDCADGQLARYSLQYSTLGAWLDATFDRAKEYAYYAGLALGAARG
                     GDDVWALALGAMVLQSCRHIVDFSFNEANHDATANTSPTAALSDKLDSVGWTVWLRRMI
                     VLPIGERWAMIAVLTALTTPRITFYALLIGCAFAATYTTAGRVLRSLTRKARRTDRAAQ
                     ALADLTDSGPLAEFLTRFARRLRLRGPACVALVTGALVVLAAALAPYGSWWPVLAAVTY
                     VLLSPVALLKPLKGALDWLVPPFYRAAEYGTVLVLAAKADVNGALPAAFGLVAAVAYHH
                     YDTVYRIRGNAGAPPHWLVRAIGGHEGRTLLVTVLAALLVPTDFKVALTALAVAVALVV
                     LVESIRFWVSSQAPAVHDEGEPA"
     misc_feature    24125..24134
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            24387..25367
                     /db_xref="GeneID:41538762"
                     /gene="galE"
                     /locus_tag="SAVERM_RS08800"
                     /old_locus_tag="SAV_1662"
                     /old_locus_tag="SAVERM_1662"
     CDS             24387..25367
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (64-207). E-value:
                     2.2e-12. Score: 38.6. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS08800_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GeneID:41538762"
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139879.1"
                     /locus_tag="SAVERM_RS08800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1662"
                     /old_locus_tag="SAVERM_1662"
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_010983101.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.8e-16, bitscore:
                     56.5, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.1e-09,
                     bitscore: 36.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWLITGGAGYIGAHVAWAMTEAGERVLVLDDLSAGVPDRLPTSI
                     PLVQGSSLDGALLKRVFAEHSVTGVVHLAARKQVGESVAQPTRYYQENVGGLTTLLDAV
                     AGAGIQRFLFSSSAAVYGNPDVDLITEDTPCAPVNPYGETKLAGEWLVRAAGRAHGIST
                     VCLRYFNVAGAASPELADTGVFNVVPMVFDRLTRGEAPRIFGDDYPTSDGTCVRDYIHV
                     ADLADAHLAAARRLTAGATGDLTVNIGRGEGVSVRELITLIGEVSGDTTPALVEPRRPG
                     DAPRAVASAALAAEELGWHARRGVREMVESAWRGWRHHHPEAARG"
     CDS_motif       24390..24476
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAVERM_RS08800_0001"
                     /evalue="3.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="SAVERM_RS08800"
                     /protein_end="30"
                     /protein_start="1"
                     /score="16.5"
                     /tool="antismash"
                     /translation="TWLITGGAGYIGAHVAWAMTEAGERVLVL"
     aSDomain        24579..25007
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS08800_NAD_binding_4.1"
                     /evalue="2.20E-12"
                     /label="SAVERM_RS08800_NAD_binding_4.1"
                     /locus_tag="SAVERM_RS08800"
                     /protein_end="207"
                     /protein_start="64"
                     /score="38.6"
                     /tool="antismash"
                     /translation="HSVTGVVHLAARKQVGESVAQPTRYYQENVGGLTTLLDAVAGAGI
                     QRFLFSSSAAVYGNPDVDLITEDTPCAPVNPYGETKLAGEWLVRAAGRAHGISTVCLRY
                     FNVAGAASPELADTGVFNVVPMVFDRLTRGEAPRIFGDD"
     gene            25724..26317
                     /db_xref="GeneID:41538763"
                     /gene="idi"
                     /locus_tag="SAVERM_RS08805"
                     /old_locus_tag="SAV_1663"
                     /old_locus_tag="SAVERM_1663"
     CDS             25724..26317
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538763"
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129457.1"
                     /locus_tag="SAVERM_RS08805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1663"
                     /old_locus_tag="SAVERM_1663"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_010983102.1"
                     /transl_table=11
                     /translation="MPITPATSTHSSSNGTAEAILLELVDENGTTIGTAEKLAAHQPPG
                     QLHRAFSVFLFDEQGRLLLQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTHEEL
                     GVSPSLLAEAGTVRYNHPDPDSGLVEQEFNHLFVGLVQSPLRPDAEEIGDTAFVTAAEL
                     AERHAKDPFSSWFMTVLDAARPAVRELTGPSAGW"
ORIGIN
        1 gcattcatag gtggctgccg ggtcgaggcc gcgcagccgg agcggggcga ccggctcgcc
       61 gtagtgctgg gcctggagcc aggcgaggac gacggcctcg tcgccgtgga cgtactgcac
      121 ggcgctcagc ccgcccgtcg ggggccgcag ccggtagagg tccccgcgct gcacgacggg
      181 ccggatctcc ttgtagagac tcacccagtc ccgtgcctcg acgagttccc gctcgctcca
      241 ctcggccaga tcgccgccga ccccgagcac tcccgccatg gcgctgacga accggaggcg
      301 cagcgtgctg actcgcccgt tgagctgtgt gttcgggctg tcggtgaccc aggcggccat
      361 gacccgggcg gggtggatct ggctgaatcc gtgctggatg gcgagccggt cgagcgggtc
      421 ggtgttgtcg gaggtccaca cctggtccgt acgcgccatg atgcccaggt cgatccggcc
      481 gccaccgccc gagcaggact cgaaggcgac ccccggatgc gcggcccgca gccggtccag
      541 caggcggtac agggcgcgca catgatcgac ccagagccgc tgcggatatg cctccccagg
      601 ccagccggcg tccgtgaagc agcggttgaa gtcccacttc acgtagtcga cgggggcgct
      661 ggacagcagt ccgtcgagct gctcccagag gcactgctgg acgtcctcgc gcgcgaggtt
      721 gaggaccagc tggttgcgga attccgtcct ggtccgcccc ggctggaact gcacccagtc
      781 cgggtgcgcg cggtacagct cgctgtccgg gttgaccatc tcgggctcga cccagatgcc
      841 gaactgcatg ccgagcgcgt gcacgtagtc ggcgagcggc ttgagcccgg ccgggaagcg
      901 gtcggggttg ggcgtccagt cgccgagccc ggcccggtcg ccggtccgcg ccccgaacca
      961 gccgtcgtcg accacgaaca gctcgacccc catcgccgcg gcccgccgcg cgagagcccc
     1021 ctgctgttcc tcggagatgt cgaaggtggt ggcctcccag gaattgaaga gcaccggacg
     1081 gtcctggtcc gcgtccggga tgacgtacgc ccgctggtac gcgtgccagg cgcggctcgc
     1141 gccgccgaag ccgccgtcgc tccacagccc cgcgaagacg ggcgtcgtga acgactcccc
     1201 cggccccagg cgcagcaggc ccgagtcgtc gtaccccgcg ccgccggtga tctgcacgcg
     1261 cgcgtcggag agttgggcca ccgagatgcg ccaggagccg gaccagccga gcgcgcagcc
     1321 gtagacctcg ccgctctcct cggtcgcctc gcaatcgagc gcgacccacg gcagatgctg
     1381 gtgcccggtg tgcccgcgcc ggctgccgat gatcttctcg ccgtaggtga ggtccgagcg
     1441 tacgaggcgg gactcggccg cccagcgccc gtgcagctgg gacagccgcc agccgtcgcg
     1501 ctcgggcagg gtccaggtgg cggagtcggc gcgcagcagc tccagggcgg gtccgtcgtt
     1561 ggccagcgtc acccagcgct cgacgacgtc gtcccgcatc cggtagtgca gcgtgacggc
     1621 cagccccgag tcgccgaacc gcagccgcag ctcgtcgcct tcggtctcgt acgcctcgaa
     1681 gcgccactcg gtgccacggc gctcgtcggt gcgcacggac agcgccgggc gtacgaagcg
     1741 ggggccgccc tcgaccgggt actcctcacg cccgtccagc ggcgattcga aggacgagcc
     1801 gcccggggcg gggagggcgg cgagggcctc ggcgtcggcg agggcgatcc gcgggcccca
     1861 gtgcagatgc agcagttcgt gaccctcggt gagatgcacg gcgtagctgc tcgtgggccc
     1921 cgaaagaagc cacgtacgtc ggtcttcggc gatctcaacc atcaggcccc cacagatgtc
     1981 aacagatgta ctcaagcatc aacatcatca agggatccgg gcctcggggg caacgcctgt
     2041 ggacaactca ttgcctcagg aacccatgtc gtatcgtcgg gaaagcgccc gccgacgagc
     2101 cgcttcgacg gggccgaaca ggaggagccc tcgtgacgca gcaggtcccg tccaccgagc
     2161 ccgagctggc cggagtgcgc aacttccgcg atgtgggcgg tctgccgacc gtggacggcc
     2221 ggcgagtgcg gcacgggctg ctgtaccgca gcggccatct cgcgcacgcc acggacgagg
     2281 acgcggcgtt cctcgcctcc ctcgacctgc acacgatctt cgacttccgc aacgccgcgg
     2341 acatcggcct cgaagggccg gacgtcgagc tgccgggcgt gcgcaatctg aacttcccgc
     2401 tgacggaccc ggcgcacggc gcggaattct ggacgatggt ccgtgacggt gatctggacc
     2461 agctacgcgg cctcctggcg gacggcaagg ccgcgaaccg gatgatcacc tcctaccgca
     2521 cgatcatcaa ggagcgcacg gccgagcacg ggcgcgtgct gcgcgagctc gccgaggaga
     2581 gcgtgcccgc gctgatgcac tgtgcggcgg gcaaggaccg ggcgggcctg tcgatagctg
     2641 tcgcgctcct ggccgtgggc gtggagcgcg atgccatcgt cgccgactac ctggagtcga
     2701 acgccccgca ccgccgctac aaggtgcggc gctccagcag cgcggcccag gcgtacagcc
     2761 ccgaggtgat ggagctgctc agcccgctct tcgaggcgcg ggccgagtac ctggcggcgg
     2821 ccttcgagac gatcgaggag acctggggcg acaccgacac atatctggag cgggggctga
     2881 agatcacgcc cgagctgcgg gagcggctgc gcgagcggct cctcgactga gaccgccccc
     2941 tgggcgcgcg gccggctact tcgcgcccag ctcgaacagc aggtagatga agcccgcgaa
     3001 gaggtgaccg accgcgatgt agatgatgag ccggacccac agcgcgcgcg ggaacttctc
     3061 ctccatggac ctgcggttct ggctggactc gggctgttct gtcatggtgt gtctcccatc
     3121 gtcgggtgtc ccgtcgccgg gccgaggcac agcgtggcgg cggggctctg cagcagggtg
     3181 tgaaggaaga gcagctcggc cccgtcgtgg tcggctgccg cgaggcggtg cggggtcagc
     3241 gagtcgaagt gcgcgctgtc gcccggcccg agcagatgtg tggtgtcgcc gaggcgcagc
     3301 cgcagccgcc ccttcaggac gtacagccac tcctcaccgg ggtggacgcg cacgacatcg
     3361 ccctgggtgc cgtacggcac gtgcacgcgc agcgcctgca tggcgcgacc gcccgcgccc
     3421 gcctgccagt acgtccagcc acccgctccg gccggctcca tgtcggcggc gcgcacgacg
     3481 gcgtcccggt cgcctacggt ctcgcccagc agctcggaga cggtcgtacc gtagatacga
     3541 gcgagtgcga gcagcatcgg cagcgagggc tggcgctgac ctgtctccag ccgggagaga
     3601 tgggccggcg agagcccggc ggcgcgggcc gcgacctcca gcgtcaggga ggcgcggcgg
     3661 cgcagcgcgc ggagctgtgg tgcgacggcg ggcaggtcct cgaccggccc ggactcggag
     3721 gaactcatac ctccattgag ccggagtttt gcctgtggga caaatctttt gccccacagg
     3781 caaaatccct gacggctacc gcttcacgtc ggcgtctacc tctgggcaac agcctgcttg
     3841 accagcgtct tcccgaagtc ccacagcagg ccgccgccgc tgtgcgcgtc gtccatcacg
     3901 gcggtgaagg cggccacgaa ccggtccacg tcccgctcgt cgatgatcag cggcggaatc
     3961 agcttgatca cctccaggtg gtcgccggag acctgggtga ggatccggtg gcgttgcagc
     4021 agcgggacga cgaccatctg cgcgaacaga cccttccggg cggcctgcag cacggtccag
     4081 cggctgcgca gcttcagcga cgtgggccgc ccgaactcga tgccgatcat cagaccccgg
     4141 ccccgtacgt cactgagcag ctcgtacgtg tcgacgagcg ccgcgagccg ggacttgagc
     4201 tgttctccgg tcgcgcgggc gttcgcgacg atctgctcgt tctccatgac ggagagcacg
     4261 gcgaggcccg ccgccatggc ctgcgcgttg gagccgaagc tcgccgagtg gacaaggacg
     4321 cggtccatcg acgaatagac cttcttgaag atccattcct tgcccagggt ggcgccgacc
     4381 ggcacatagc cgcccgacag cgccttggcc acacagacca ggtcgggctc cacgccctcc
     4441 tcgtgctggt aggcgtagaa gtcgccggtg cgcccgaggc cggtctgcac ctcgtcggcg
     4501 atgagcagcg ccttgtgcct ctgcagcagg tcctgggcgg cgcgcagatg tccgggcggg
     4561 gcctcgtgga cgcccttgcc ctggatcggt tcgacgatca gggcggcgac gtcgcccttc
     4621 ttcagctccc tcgccagggc gtcgagatcg ccgagtggga cggcggtgtc gggcagcagc
     4681 ggggcgaagc cgtcgcggaa gccgtcctcg ccgttcacgg acagcgagcc ggtggtcagc
     4741 ccgtggaagg cgtgcgagca gtacaggatc cgcggcttcc cggtggcgta ccgggcgaac
     4801 ttcagcgcgg tctcgaccgc ctccgtgccg ctgttgccga agaacacgcg gtcgaggtgc
     4861 gggctgtgcg tgagcagctt ctccgccagc agtccgggca gtggctggca gtcgaagcgg
     4921 gtgaggtcgg cgagcgaggc gtccaggacg tcgtgcagcg ccttgcggac gacggggtga
     4981 tggcggccca ggcccatcac cccgaacccg gcgagcatgt ccaggtagtc cttgccgtcc
     5041 gcgtcccaga agtgcgcccc ttcggcccgc tcgtacacct tgtcgaagcc gatggtgtgc
     5101 agcatgcgcg ggagctggtg attgaggtac ttggcgtgca gttcgtagcg ctcggcgccg
     5161 cgctcggcca gcagggcgcc gaggtcgaac tcccggtttc cggaaggggc cccctccgac
     5221 ggcgccttcc ctgaggggat ggtcattcct gtttctcctt ggacagctct tccttggtgg
     5281 ccagccccgc gctgatccgc ccggcgatct cgacgggcgt caggcctatg tcggccagca
     5341 cctcggcgcg cttggcgtgc gcgaggaact gctccgggat accgaaccgc cgtaccggca
     5401 cgtcgacttc ggcgtccgag agggccagcg cgaccgcggc gccgacgccg gccgcccggc
     5461 tgttgtcctc gacgaccgcg accagccggt gctcggcggc cagccccggc agcgaagggt
     5521 cgacgggctt gacccagcgc gggtcgacga ccgtgcagcc gatgccccgc gcctcgagca
     5581 gttcggcggc ctggaggcag accggggcca tgacaccgac ggcgaccagc aggacctgcg
     5641 gagactcggg aaagcggtgc agtacgtcca tgccgcccac atggtcgacc gccgggatcg
     5701 cgggccccac ggactccttc gggaaacgca gcagcgtcgg cgcgtcgtcg accgccaccg
     5761 cctcccgcag ctgggcccgc agctggtcgg cgtcgcgcgg tgcggcgatc ctgaggccgg
     5821 gcaccacctg gaggatcgac atgtcccaca tgccgttgtg ggaggcgccg tcgacgccgg
     5881 tgaccccggc ccggtccagc acgaaggtca ccccgcagcg gtgcagcgcg acatccatca
     5941 acagctggtc gaaggcgcgg ttgaggaagg tcgcgtacac cgctacgacc ggatgcagcc
     6001 cgcccgtggc gagacctgcc gccgacaccg ccgcgtgctg ctcggcgatc ccgacgtccc
     6061 agacccggcc ggggaacttc tccgcgaact tgttcagccc caccgggtgc agcatggccg
     6121 ccgtgatcgc cacgacgtcc tcgcgctcct cgccgatccg gacgatctcg tcaccgaaca
     6181 ccgaggtcca ggaagggccg ttggaggggg cgaggggctc gcaggtgagg gggtccatca
     6241 cgccgacggt gtggaaacgg tcctcgtcgt gggcgagcgc gggctcgtat ccccggccct
     6301 tctccgtcag gcagtggatg agcaccggcc cgtggaaacg tttcgcgcgt ctgaacgccg
     6361 attccatcgc cttcatgtcg tgcccgtcga tcggccctac gtacttcagc cccaggtcct
     6421 cgaacatgcc ctgcggcgcg aacgcgtcct tgaacccctt cttcgcgccg tgcagcgact
     6481 cgtagagggt gttgccgacg accggcgtgc gcagcagtac gtccttgccc caggccagca
     6541 ccttctcgta gctgtcggtg gtgcggagcg tggcgaggtg gttggcgagg ccgccgatgg
     6601 tgggcgagta cgaacgttcg ttgtcgttga cgacgatgat cagcgggcgg tccttggcgg
     6661 cggcgatgtt gttcagcgcc tcccaggcca tgccgccggt cagcgcgccg tcgcctatga
     6721 ccgcgacgac atgccccttc tcgccctgca cctggcgggc cttggcgagc ccgtccgccc
     6781 agccgagcac ggtcgacgcg tggctgttct cgatgacgtc gtgctcggac tcctcgcgcg
     6841 agggatagcc ggacaggccg cccttgctgc gcagcttgga aaagtcctgc cgcccagtca
     6901 gaagcttgtg cacatagctc tggtggccgg tgtcccacag gatgcggtcg accggtgact
     6961 cgaaggcccg gtgcagtgcg acggagagtt ccaccacccc cagattgggc cccagatggc
     7021 ctcctgtcct ggcgaccgca tgcaccagga actcccgtat ctcttcggcc agttcaccga
     7081 gttccgcctc ggacagcgcc ttcaggtcgc gtggtccccg gatgttctcc agcatcgtca
     7141 cgtcgggccc cctctcggtc cgtagctgct caactcacgg tgacggccgg ttccccggac
     7201 gcgacgccgt tctgctccat ctgctcggcg atcttcatcg cctcctcgat cagggtctcc
     7261 acgatcttcg actcgggcac cgtcttgatg acctcgccct tcacgaagat ctgtcccttg
     7321 ccgttgccgg aggcgacgcc gaggtcggcc tcgcgggcct cccccggccc gttgacgacg
     7381 cagcccatga ccgcgacgcg caggggcacc tccatgccct ccagacccgc cgtgacctcc
     7441 tcggccagct tgtagacgtc gacctgggcg cgcccgcagg acgggcagga gacgatctcc
     7501 aggcgccgct gcctgaggcc cagcgactcc aggatctgga tgccgacctt gatctcctcg
     7561 acggggggcg cgctcagcga gacgcggatc gtgtcgccga tgccctcgct gagcagcgcg
     7621 ccgaaggcga cggccgactt gatcgtgccc tggaaggcgg ggccggcctc ggtcacgccg
     7681 aggtgcagcg ggtagtcgca ctgcgccgcc agctggcggt acgcgttgac catgaccacc
     7741 gggtcgttgt gcttgaccga gatcttgatg tcccggaagt cgtgctcctc gaagagcgac
     7801 gcctcccaca gcgccgactc gacgagcgcc tcgggggtgg ccttgccgta cttctccagc
     7861 agccgccggt cgagcgagcc cgcgttgacg ccgatgcgga tcggcgtgcc gtgctccttg
     7921 gcggcgcgcg cgatctcctt gaccttgtcg tcgaactgct tgatgttgcc cgggttcacc
     7981 cggaccgccg cgcagcccgc ctcgatcgcc gcgaacacgt acttcggctg gaagtggatg
     8041 tccgcgacga cggggatctg cgacttgcgg gcgatgaccg cgagggcgtc cgcgtcgtcc
     8101 tgcgtggggc aggcgacgcg gacgatctgg cagccggacg cggtgagttc cgcgatctgc
     8161 tggagcgtgg cgccgatgtc cgacgtacgc gtcgtcgtca tcgactgcac cgacaccggg
     8221 gccgtgccgc cgaccgccag cggtccgacc tggatctgcc gggagacacg gcgttcggcg
     8281 atcggacgga cgggcacttc ggggacgccc agggaaatgg ccgtcatgac gtcacccgcg
     8341 gtttccggag acggtctcgc gggccgcgcg cagggactcc ttgagggaac ccatcgtggc
     8401 caggacggcg gtcggctcgt agccgcagtg cgccatgcag ttggcgcagc gcgggtcctt
     8461 gccgcgaccg tacgcgtccc agtcggtgtc ctcgatgagc tcccggtacg tcgtgacgta
     8521 cccgtcgctc atcagatagc agggcttctg ccagccgaac agcgagtagt tggggatcgc
     8581 ccacgccgtg cacgggaagt cgaccttgcc ctcgaggaag tcgaggaaca gcggcgagtg
     8641 gttgagccgc cagcgccgcc ggttgccgcc cgcgaacgcc ttcctgaaca gctcgcgggt
     8701 ctgctccacg ccgagaaaat gctcctggtc gggcgccttc tcgtaggcgt aggcgggcga
     8761 gatcatcatc tcgtccacct cgaggtcgtc attgaggaag ttgagcacct cgatgatcgt
     8821 ctggggggtg tcggtattga agaaggtcga gttggtggtc acccggaagc cgcgcctctt
     8881 ggcctccttg atggcctcca ccgcctcgtc gaacacgcct tccttcgcga ccgactcgtc
     8941 gtgccgctca cgcaggccgt cgatgtgcac ggcgaacgcg aagtagggcg acggggtgaa
     9001 gtcgaccatc ttcttgcgca gcagcatggc gttggtgcac aggaagacgt acttcttcct
     9061 ggccaccagc tgccgcacga tctcgtcgat ctgggggtgc atcagcggct cgccgccggc
     9121 gatggacacc atcggcgcac cggattccag caccgcaccg acggcctgcg ccaccggcat
     9181 gcgctgcttg agcactccgg ccgggtgctg gatcttgccg cagccctcgc acttcagatt
     9241 gcaggcgaag agcggttcca gctccacgat cagcggaaac ttctcccgct tgcggagctt
     9301 ctgttcagcg agatacgtcg cgaccttgat ggtctggcgc agtggcatgg ccatctggct
     9361 cacctccggg ggagcagcaa agaacggtgc cattcgaaga aagcgggaag tacggcacgg
     9421 agaacgcgga aggctgatat tccaccgcgg accgtgccga tacggacgag ttcatgttct
     9481 ggagcgtcca cgaccactcg gacggccgca accgggcgcg tgcccgtgca cacggcgccg
     9541 tggagcgtgg acgcggattc catgtcggcc gcgattgcgc cggtcaggag cagatccgac
     9601 cgttcgtgac cgcggacgac gtgatcggag ccgatgagcg gccccgtgtg gacggtgcgc
     9661 ccgggcacgg cgcggacgag ttccttgacc agcacctcgg tgcccacgca cggggtgact
     9721 ccacgcgggt cccgggtctc ctcggcgacg acgagatcac ccgggtgcat accgggagcg
     9781 agccccgcgc agaagcccgt ggccacgacg gcggcctcac gcagcgccgg gtcggcgagc
     9841 acccgggtga ccgcccgctc ggcggccttg ggccccatgc ccgtacgcag caccgtgacg
     9901 ggcccgtcgg caccgccgcg gtcgccgctg cgcagcgcca ggcgctcgat gccgagcgcg
     9961 cacgcgatga gcagcggggc cggatcgggc ttcgtgctca tcaacccccc ttgacctcga
    10021 cgagcggctc gccgttgacg taccggccga gcgcggtgag cgggaagacc tggcggtaga
    10081 ggtggtagtt gatcgagaag tcccagggga acccggtgcc ggtgaagtac ggctcgtccc
    10141 aggagccgtc cggccgctgg gtctgggcga gccattcgat cccgcgctcc accgctttgg
    10201 actcgcgctc ccccgccgcg agcagtgcga gcagcgccca ccccgtctgg gaggcggtgg
    10261 aggcgccttt gccgctccac tcggcggcct cggggtagga gcgcaggtcc tcgccccagc
    10321 cgccgtcgtc gttctgcacg gtctccagcc aggtgacggc acggcggatc gcggggtgcg
    10381 aggcggggag tccggcggcg accagcgcgg ggaccaccga cccggtcccg tacacgtagt
    10441 tgacgcccca gcgcccgaac caggagccgt tggcctcctg cgcggagagc agccactgga
    10501 tgccgcggcg ggtgcgcggg tcgtgcgaca ggccctcgaa cgccagcatc tccacgacgt
    10561 gcgcggtgac gtcggcggac ggcgggtcga tgacctcgcc gaagtcgcag aacggcagcc
    10621 ggttgggaaa cgggctggtg ttgtcgacgt cgaaggcgcc ccagccgccg tccttggact
    10681 gcatgccgag gttccagcgc accccgcgcc ggatcgcgtt gtccaggcgc tcggggtcgt
    10741 ggtgcttgac gcgacgcagc gcgaggacga cttcggcggt gtcgtcgatg tcggggtagt
    10801 tgtcgttgtg gaactcgaac gcccagccac ccggcggcag ttggggacgt ttcaccgccc
    10861 agtcgccggg ccggacgatc tcctcgccga gcatccagtc cgccgcccgc acgagctgcg
    10921 gatggtcggc gggcacgccc gcgtcggcga gcgcgatggt cgcgaggcag gtgtcccaca
    10981 cgggcgactg gcaggcctcg atcatccgcg ccccgtcgtc gcgccacacg gcgaaccggt
    11041 ccagtgacgc cagcccctcg cgcatcacgg ggtgttcgag gtcgtagccg agcagataca
    11101 gggcgatgac cgagtacacg gcgggcggct ggataccacc ccagcagccg tcgttctcct
    11161 gccgctcgat gatccagcgc gcggccgtgt tcatcgcggc cttgcgcagc ctgcgcggcg
    11221 cgaccttgcg gtacgtgtgc agagcgacgt cgagccgctg gaataatccg tcccaactca
    11281 ccatcggggc aaggggcttg gccgggttgg ggtcattcgc gtcggcgtgc agttcatcga
    11341 gcgggaacgg ggcgggccgc accggacgct tcgccgagac gacggtgagc ggcacgatgg
    11401 tctgccgcgc ccagcagccg aagtcgtaga tgttgagcgg catccacttc gggaagtaga
    11461 tgagttccgg cgggagttcg ggcaggtcgt cccacttcca ccagccgaac agggcgagcc
    11521 agatccgggt gaagacgcgg gccgaggcga tgccgccccg ctcgcggatc caggcggacg
    11581 ccttcgccat gtgcggctcg tccgggccgt caccggccag gcgcagggcg acatacgcct
    11641 cgatggtggc ggagaggtca ccggggccgc cgtagaaagt ggcccaggtg ccgtccgcac
    11701 gctgctcgcc cctgatgaac agtccggcgg ctcgtgtggt cttctcgtcc tggattccca
    11761 ggaactgacg gagcagcagg tcctcggcgt ccatcgtgac gttcgtctcg aggtcgccct
    11821 tccaccagcc ctcggcgtcc tgccgcgaga gcaggaagtc ggtggcgcgc tgtgtggcgc
    11881 gcgcggcggc gtcttggatt ccgacactcc cggccgcctg cgggatcgtg tcgtgtggtt
    11941 cgctggccga ggcagcgcgg ggcggcaggg ccccggtgct tccgtcggtc gtcgctgtca
    12001 tggcttcccc ttcgtgcagt ggtacgactc tgctgtgggt ccgccgtcgg ccagtgcttc
    12061 tctctgctcg cggcaccggc cggcgactac gcgaggttta ttcgaccgat agtgatcatc
    12121 tcttccgtac gacgacgaag tcggcgagcg ccacgagctg ggcccgcacc tgctggggca
    12181 tctcgatcgt gtccagggcc tcgatggcga tcgtgtgctg gcgccgcgcc tcctgggcgg
    12241 tccactcgcg accgcccgcc tcctcgatga gcgcggcacg cgcggcgaac tcctcttcgg
    12301 agaagttctc gaagtcgctg ctcttggcgt cctcggcgag cagttcgccg agccgccggg
    12361 aggcgggtcc gcccgcggcg agcgccgcca cgaccgggag ggacttcttg cgctggcgca
    12421 ggtcgctcca ggtctgcttg ccggtggact ccgggtcgcc ccagatgccg aggaggtcgt
    12481 cgacggcctg gaaggcgagg ccgaggtggt agccgtactt ctccagggtg tcggcggtgc
    12541 ggtcgtccgc gccgccgagg accgcgccga tggagcaggc gcaggcgagc agcgcgccgg
    12601 tcttgttgcc ctccatctcc aggcactcct cgacggtgac ccgctcgcgg tgctcgtagg
    12661 agatgtcctg cgcctggccg tcgatcaggg cgcggctggc ggtggtgagg cggcgggtgg
    12721 cgcggcccgc ctcgaccgtg ccgagctcca ggaggatctc gttggccagc gcgaagaggg
    12781 cgtcgccgac gaggatggcc tgggcggggc cgtgcacctt ccagacggtg tcgcggtggc
    12841 ggcgctgttc gtcgccgtcc atcaggtcgt cgtgcagcag cgagaagttg tgcaccagtt
    12901 cgacggcgac cgcgcccggg acgcccacct cgggggcggc accggcggcc tgcgcggaga
    12961 gcacggcgag ggcggggcgt acggccttgc cgccgtcacc gtccgcgggg ttgcccgcgg
    13021 cgtcgatcca gccgaagtgg taggcggcga cggtgtccat gggcggtgcc aggcggtcca
    13081 cggccgcgcg cagcaccggg gtggacaggg tccggccgcg ctccaggagc gcggtcacgt
    13141 ccaccgcgtc ggcagccttc tcggccgggg gcacagtggg cacagtctct cctcttgttg
    13201 cggtacgggg ggtgcgggga ccagtcccgt gcagatcggg cgtcacgccg cctcctcgaa
    13261 gagttcgagg aggtgatctc ggggccggcc cagggcgttc agggcggcgc ccgccgcact
    13321 gacaccgctg cggaccgcac tctccatggt cgcgggccac cctgtggcgg tccacgcgcc
    13381 ggccagacag aggccgggtg ccttggtgcg ggcgccgggc cgcagccgcc cgacgccggg
    13441 ggtgggggcg aacgtcgccg tgcgctcccg ggtcacgaag aagtccttca cctgcgcgcc
    13501 gcgcgtcgcg ggcaacagcc gctccagctc cggcagatag cgctcacgca gcacggagac
    13561 gggctcgtcg atctcgtcct gcgcggccga ctgggagagc gccaggtact gcccctcggg
    13621 cagcccggag gcctcggtgc ggtcgaagac ccactgcacc ggagagccga gcgccgcgaa
    13681 gaacgggcgg ctgagcacct tccggtcgta gacgacatgg acgttgagga tcggcgcggt
    13741 gccgatctcc agcagccgct cgggggcgtc gagcgcgcct tcgggcagca gttcgtgggc
    13801 ctcgcgctgg ggtacggcga ggacgaccgc gtccgcgtgc agcgtctcgc cgggaacctg
    13861 aacgctccaa cgcccgtttc cgttgaggga gatggaggtc acgcgtgtac ggacttcggt
    13921 acggacgccc acggagtcga gcgccttgcg ggccagccgg tcgtgcagtt cgcccagcgg
    13981 gacgcgcgcc cagccgatgt cggcggcgcc cgggtcggac agcagaccgg tcttgaacac
    14041 catcgcggcg agcccgagcg aggaatcgcc ggccaccgcg ttgagggtgg cgaccccgac
    14101 caggtcccac agtgcctcga cggcacgcgc cgactgaccg tgcgcggcca gccagctgcc
    14161 gaagttctgc gtgtccagcg ccggatccgc gaggtcgagt cccttgagcg ccagtgcggc
    14221 gcgcccgact ctggcgcgct cggcgagcga gagatgcgga taggtggcga ggctcttcgc
    14281 gagatgcagc ggcaccggca gcgcggtgcg gccgattctg ccgagccgcc gtcccggctt
    14341 gcccccggca tcgagaacgg gcacgtcgag acgatcctgc aagggggcca gcgaggcggc
    14401 gtcgatgcgg tcgaggaacc agcggtacgc cgtgcagcag cgcagataga cgtgctggcc
    14461 gttgtcgacg gtcagggcgc cgcgctggaa ggagaaggcg agcccgccga ggcgtggcct
    14521 tccctccagc agcgtcacac gcactccggc gtcggcgagg gcgagcgccg cggtgatgcc
    14581 ggcgagtcct ccgccgacca ccacggccgc cctctcgggg cggccggagg cctccgcgtc
    14641 cggcccctcg agccgagtgg cgtcgctcat cgcgcatcct cccctgccgg tccgccgcgg
    14701 tgcttgaacg gtgcacggca ggccgttgca gtcagggacg cggtgcacca ccggagggtt
    14761 gcgtgccgct tttcgccgct ggaatcacct tggcccacat tgtccatcag acgcgcctcc
    14821 tgacggtgcg ccgggacaca tgccgggcgt cgaggcccga caggccacgc acggcgacgt
    14881 acgccttctc gcgtccgggc agcgagaccc ggccgcgcag tacggcctcc ggctcgcgct
    14941 cgatgcgatc gaggagccgg cggtagatgc ccgccatcgc ggcgacacag gcaccgctgc
    15001 gccggtccag catgggcagc agccggtagc cctcggcgaa aagggcgcgg gcccgacgca
    15061 cttcgaagtg cacgaggccc gcgaagtcgg atccctccgg tgggatcggc cggtcgaacc
    15121 cggccgagca gccgaatttg gcgaggtcgt cggcgggcag ataggtgcgg ccgccctcgg
    15181 cgtcctcgcg tacgtcgcgg aggatgttgg tgagctggag agcgaggccg agggtgtcgg
    15241 cgtactctga cgcgcgctcg gcgccgcggg cgcccggttc cgtgccgaac acgccgagcg
    15301 agacgcggcc gatggcccct gccacacagc ggcagtagac cttgaggtcg tcccaggtct
    15361 cgtaggtctc gccgcgcacg tccatgagga cgccgtcgat cagttcgtcg aggccgccga
    15421 gcgggatcgg gaactgctcg gcggcgtgcg ccagggcgac cgcgacgggg tccgtgtcgt
    15481 cctcgtccac ccgcccgtca cgcacccggg acagcagcgc ccgggtgtcc tcgagcctcg
    15541 ccgccttcac gtcgggcgcg agcgcgccgt cgccgatgtc gtcgacgcgc cgcgagaagg
    15601 cgtagaccgc cgacatcgcg cggcgcttgg gcgtcggcag cagcctgatg ccgtaggcga
    15661 agttgcgggc ctgctgcccg gtgacggtct cgcagtagct gtatgcggcg agtaccggtg
    15721 cggacacgtg ttgttccgac tccacggtcc ggatcacccc tctcctcgca gagtcacgcc
    15781 cacctcgcgc agcagctgaa gcttgccggg cttgggcggg ccgggaagta cgtcgtattc
    15841 ggcggcggcg atcgcgcgga tcgccgccct tccccccgcc acgaaccccg cgagcagcag
    15901 cctcagcctg ccgtggacgc tacccacgag aggggtgcct tcattcagga ggttcagggc
    15961 gcgttccgtt tcgtatgcga ccagggcgcg caccgatgcg cctgctgtgg ccgtggcaag
    16021 atccgcctct tgcacatgga agcgcttcat gtcctcggcg ggcagataga cgcggtcacg
    16081 gcccaggtcc tcggagacgt cctggaggtg ctcgacgatc tggagcgccg tgcagatcgc
    16141 gtcggagcgg cggacgcgct cgggggtgga ggtgccggtg acaccgagga cgaggtggcc
    16201 gaccgggttg gcggacagct cgcagtaggc gaccaggtcg tcgtaggtct cgtaccgcgt
    16261 gacgagctgg tcctggcggt tggcggcgat caggccgagg aagggctcgg ggctgagacc
    16321 ggtgcgccgg accgtgggct ggagcctgcg gagcaggggg tggcgcgggg tggagtcgaa
    16381 cacccggtgg aggtcggcct cgaaggcgtc caggagggcc agccggtcct cggcctcccg
    16441 cggggacaca ccgagcaggc gggcgtcggc accgccgggg gccaggtcgc cgtcgccgat
    16501 gtcgtcgacg aggcgggcga agccgtacac ggccatcagg tcggtgcgcc aggccctggg
    16561 caggaagaac ggcgccacgg ggaagttctc gtccgcggcc ttgtcgaggg tgtcgcgctc
    16621 cgggtccgcg gcgcgcgccg tcccggcttc ggtcactgct cgccacccgg cgcggggacg
    16681 gcacatgcct cgcggcgctg gagaccttcc gtagccattg ccgtcacatc tcccgttcta
    16741 cactgccgac ccaatacatc ctatttcgga cacgccgccc ggttcgtcgc acagcgtgac
    16801 cggtgtgggg gtgtcgcgcg ttatcgcccc acttgccgcg aatcagcacc ggtacagctt
    16861 acgttgtaca acgcgccatg ctccgtcggg gtgtcctgcg catcacaaca acacaccgat
    16921 tggcgtcaag attcctacgg acagccagag ttggcgcttc ctttgcagac gcagggcccc
    16981 gccgaagcgt tccggcgggg ccctggactc ttcgagctac ttgcccgtga acttctcgta
    17041 ctccttgaga acctcttcgg tcgggccgtc catgcggagc tcgccgcgtt ccagccagag
    17101 cacgcggtca caggtgtcgc ggatcgactt gttgttgtga ctgaccagaa acaccgttcc
    17161 ggcctccttg cgcagctcgc ggatgcgggc ctcggagcgc ttctggaact tccggtcgcc
    17221 ggtggcgagg gcctcgtcga tcatcaggac gtcgtggtcc ttggcggccg cgatggagaa
    17281 gcgcaggcgc gccgccatgc cggacgaata cgtccgcatc gggagcgtga tgaagtcgcc
    17341 cttctcgttg atgcccgaga agtcgacgat ctcctggtag cgctccctga tctgctctcg
    17401 ggacatgccc atggcgaggc cgcccaatat gacgttccgc tcgcccgtca ggtcgttcat
    17461 cagcgcggcg ttcacgccga gcagcgaggg ctggccgtcc gtgtagacct tgcccttctc
    17521 cgcgggcagc aggccggcga tggcccgcag cagggtggac ttgccggagc cgttggagcc
    17581 gatcaggccg atggcctcgc cccggtaggc ggtgaaggag acgcccttga cggcgtgcac
    17641 cttgcgcacc ccgcgctcct cgccgcgctt gacgatgcgg ctgagggcgg cggtggcgct
    17701 gcccttgccg gtcttggcac cgttgacgcg gtagacgatg tgcagctcgt ccgcgatgac
    17761 ggtgggaatg tgggagtcgt tccgctgctc agccacggcc gtaccgctcc tccgccttcc
    17821 agaagtacac gaagccgccg agcgccacga ggacggccca gccggcggcg accgcccaga
    17881 cgtgcggggg caggttctcg gagccgtacc cgtcgatgag cgcgaagcgc atcaggtcca
    17941 tgtagatggc ggcggggttc cactgaagga cgtcggcgac ccaggccggc ttgtcggcca
    18001 gcatgaccgg gatcgagaac atcacgccgg acgcgtacat ccacgtacgc atcacgaacg
    18061 gcatcagctg ggcgaggtcc ggggtcttgg cccccatcct ggccatgatc agcgcgaggc
    18121 cggtgttgaa gaggaactga agcgcgagga ccggcacgat cagcacccac gaaaggctcg
    18181 ggtagctgcc gaacccgatc gcgacgagga acagcacgat catcgagaag agcagctgct
    18241 ggagctgctg gagcgagaac gagatcggca gcgcggcgcg cgggaagtgc agggcgcgca
    18301 ccaggccgag gttcccggag atcgcgcgta cgcccgccat caccgagctc tgcgtgaacg
    18361 tgaagacgaa gacgccggtg accaggaacg ggatgtacac atcggacggc atgcccttgc
    18421 tggcgtgcag gatcagaccg aagatcaggt agtacacggc cgcgttcagc agcggggtcg
    18481 ccacctgcca cagctggccc agcttggcct ggctgtactg ggcggtgagc ttcgcctgcg
    18541 agaaggccag gatgaagtga cgccgcccca ggagctggcg gacgtactcg acgagcccgg
    18601 gccgggcacc gctgaccgcg agcccgtact tggcggccag ctcggccccg gagagccctt
    18661 cgtcgggcga cggccgggcg ctcaccgcga caccgccgtc atgcgttgtc tcactcacaa
    18721 gtggatgctt tcgtcctcaa agtgcgcagc cttgtcggac ctaggcggga gccagggacc
    18781 ggggtacggc cgaatgctct cagatatcga gcttgtcaga tgacgggagg tcggcccagt
    18841 cgggtcaggc gccacaccgt acgccacttc atcgggcgcc ggggtccgca cgggctggtc
    18901 cagccctcct tgaagccgcc gaaccatgcc ttgagggcgg ggcccgaggg gcggcgggcc
    18961 agcgtcagga gcagccagac gcccaggtag accgggacga ggggggcggg caggttgcgg
    19021 cgggccagcc agacgcggtt gcgggccacc atgcggtggt agaccgcatg ccgcgacggg
    19081 gcggtcgtgg ggtggtacag caccatgtcg gaccggtagt cgatcatcca gcccgcgtcg
    19141 agggcccgcc aggccaggtc ggtctcctca tgggcgtaga agaactcgtc cgggagcccg
    19201 ccgacctcgg cgagcacctt cgtacggacg gcgttggcgc cgccgaggaa ggtggtgacg
    19261 cgtgagctgc gcatcgggtc ggaggcgcgc agccgcggca cgtggcgacg ctgggtctca
    19321 ccggtgtcgg ggtcggcgat gcggaagctg atgatgccga gttccgggtc ggccgtgaag
    19381 gcctggcggc acagttcggc ggtgtcgtgg tgggcgagca ggccgtcgtc gtccaggaag
    19441 aggaggatgt ccacgtcggt gccgccgggg ccgaaggcct cgatcccgac gttgcggccg
    19501 ccggggatgc cgaggttctc gggcagctcg acggtccgga cgcccgcggg gacgtccggg
    19561 acgggagagc cgttgccgac cacgaccacc tcgacgcggt cgccgtcctg cttggcgacc
    19621 gagtcgagga gggcacggag ttcgtcgggg cggttgccca tcgtgatgat gaccgcgccg
    19681 acctttgtgg cggtgctcac ttcagcctgc tcgacgcgag gatggacacg aggtgcagca
    19741 gggtctggag cagggcgatg cccgccagga ccgctacgcc gaggcgcgag aagtacaggt
    19801 cgccccggat cgagtccagg atcgccagga ccaggatcag cagggacgcc tcgaccccga
    19861 ggacgagccg gtggaacttc aacgcggcgg cggccttgcg ggccagcgcc atgccggacg
    19921 agcgcggctc ggaggccgcc tccttgaccg gcggcaggcc gccctggtga cgggcgacac
    19981 cgacaagatc ggtctcggcc ttgatcagga tggcgccgag agcggcgagg gtgccgagga
    20041 aggcccacag ccagtcgatc cggcccgagc cccacaggtc ggcggcgcgc aggccgaaac
    20101 cgaccaggac cgcggcgtcg cacaggtagg cgccgacccg gtccaggtac accccgccca
    20161 gcgagaactg ctgcttccag cgggcgacct cgccgtcgac gcagtcgagc agcaggtaga
    20221 gctgaaccat caccacgccg agcacggcgc ccgtgatccc cggcaccagc agggccgggg
    20281 cggcgaggac gccggcgacg gtcatcacgt aggtcagctg gttgggcgtt atccgcgtgt
    20341 tcaccaggtg ccggtcgatg cgcagcgaga gctcgcgcat gtagagccgg ccggcccagt
    20401 gttcgccgct ccgccggtcc ttcacacccg gagggtgaac gaccgggcgg agctcagcta
    20461 ccgatggctt ttgcatagtc ggcgtatgcg tccctgatct gttcggtgtt caggtcgagg
    20521 tgttcgagga tcgtgtagcg gcccggcctg gtctgcggag cgaactccac gacctggacg
    20581 aactcgtcca cggtgaagcc gatctcgtcc ggcagcacgg ggaggccgtg gcggtgcagg
    20641 acctcggcca tgtaccccga ctcctcgtgc gcgccgcgca gatgcatcgc gaaggccgcg
    20701 cccatgccgc actgctcgcc gtggctcgcc gcgcgcttgg ggaagaggag gtcgaaggcg
    20761 tggttgatct cgtggcaggc gccggaggcg gggcgggagt cgcccgcgac cgacatggag
    20821 atgccggtga ggaccaggcc ctcggcgagc acctggagga agctgtcgtc gccgacgccg
    20881 cccgggtgcc gcagcacggc ctcgccggcc tggcgggcca tcgcggcggc caggccgtcg
    20941 atctgctcgc ccttctcccg gtgggccagc tcccagtccc tgaccgccga gatgttggac
    21001 agcgcgtcgc cgatgccgga gcgcacgaag cggaccggtg cctcacggat gacgtcgagg
    21061 tcgatgacga ccgcgatcgg gttcggcaca ccgtaggagc cgcggcccgc gtcgttgtcg
    21121 agggtcgcga ccggcgagca cagaccgtcg tgcgagaggt tcgtggcgac ggcgaccagc
    21181 gggaggccga tacgtgccgc ggcgaacttc gcgcagtcga tgatcttgcc gccgcccaga
    21241 cccacgaccg cgtcgtagtg cccggacttc atgtcgtccg cgagcttgat cgcgtcgtcc
    21301 agggtgccgc cgccgacctc gtaccaggtc gcgcccggca gcgccggggc gagccgctcg
    21361 cgcagcttgg ccccggagcc gccgctgatc gcgacggcga gcttgccgga gtgcgagatg
    21421 cgctggtcgg cgaggacact cgccaggtcg tccagggcgc ccggacggat gtcgacgacg
    21481 accggcgagg ggatgagcct cgtcagtact ggcacgcgat ttcacgtccc ttggcgaggt
    21541 cctcgtggtt gtcgatctcg acccacttga cgtcgccgat gggcgcgacg tcgatgcgga
    21601 agccgcggtt gacgagctcc tggtagccgt gctcgtagaa ctgctgcggg tccgtctcga
    21661 agaccgtctt cagggcgtcg gcgagctcgt cggccgcctc gccctcgatg agggtgacgc
    21721 cgatgtactc accggtcgcc tcggccgggt ccatcagctt ggtgatcttc gtcatgccgc
    21781 cctcggggcc gacgacgacc ttcatctcct cgtcggcgag ggacttcacc gtgtcgaggg
    21841 cgaggatgat cttcttgccg tcgccgcggg cggcgaggag ggtcttctcg acggagaccg
    21901 ggtgcacggt gtcgccgttg gcgaggatca ccgagtgctt gatggcgtca cggccgcacc
    21961 acagggagta ggcgttgttc cactcctcgg ccttgtcgtt gtcgatgagg gtgatcttga
    22021 gcccgtactt ggcctccagc gcctcgcggc gctcgtagac ggcctccttg cggtatccga
    22081 cgatgaccgc gacctcggtc aggccgatct ccgcgaagtt gccgagggtg aggtccagga
    22141 ccgtgaggct gtcctcgttg ccctcggggc caaccggcac cagagccttg ggcagggtgt
    22201 cggtgtaggg gcgcagacgc cgtccggcgc cggccgccag cacgaggccg atcatgcggg
    22261 ttctccttca tcgtgtacgg cgggtgcttg ggaggacacc cagaagcgga tgctctcgac
    22321 gagcaccacg agtgccacgg ccacggcgag tgccgtgagc gcgaccttga aatctgtggg
    22381 gacgagcagc gcggccagaa cggtgaccag cagcgtcctg ccttcgtgcc ccccgatcgc
    22441 acgcaccagc cagtgcggcg gcgcgccggc gttcccgcgg atgcggtaca ccgtgtcgta
    22501 gtgatggtag gcgaccgcgg ccaccagtcc gaaagcagcc ggcagcgctc cgttcacgtc
    22561 cgctttggcg gccagtacca gaacagtgcc gtattcagcc gcacggtaga acggcggaac
    22621 cagccagtcc agcgcgccct tgaggggctt cagcagggcc acgggcgaca ggagtacgta
    22681 cgtcacggcg gccaggacgg gccaccagct gccgtacggg gcgagagcgg cggccagcac
    22741 cacgagagcg cccgtgacaa gagccacgca ggcgggaccg cgaaggcgca gcctgcgcgc
    22801 gaagcgcgtc aggaactcgg cgagcggccc ggagtccgtc aggtcggcga gagcctgggc
    22861 cgcgcggtcc gtccgccgcg ccttgcgcgt cagtgaccgc agcacccggc ccgccgtggt
    22921 gtacgtcgcc gcgaaggcgc acccgatgag cagcgcgtag aaggtgatgc ggggagtcgt
    22981 cagtgccgtg aggacggcga tcatcgccca gcgctcaccg atcggcagga cgatcatgcg
    23041 gcgcagccac accgtccagc cgacgctgtc gagcttgtcc gagagggcgg cggtggggct
    23101 ggtgttggcg gtggcgtcgt ggttcgcctc gttgaaggag aagtcgacga tgtggcggca
    23161 gctctgcagg accatcgcgc cgagggcgag cgcccatacg tcgtcgccgc cacgggccgc
    23221 gccgagggcg aggcccgcgt agtaggcgta ctccttggcc cggtcgaagg tcgcgtcgag
    23281 ccaggcgccg agcgtcgagt actgcaggga gtaacgggcg agctgcccgt cggcgcagtc
    23341 gaggacgaag gagaacagga gcagcaggcc ggccgcgacg aacccggcgc gggtgccggt
    23401 ggccgcgcag cccgccgcga ccagggcggt gagcagggac gcggtggtga cctggttggg
    23461 ggtcagaccg cggcgggcgc accagcgggc caggtagcgc gagtacgggc tgatgaagtg
    23521 ggtggtgaag aagccgtccc gggacttcac ggcggtacgc agccgtaccg cctcgtcgtc
    23581 gacggccgtg acggcctggc ggacctcgtt gcgggcctgc gggtcggcgg ggacggcggc
    23641 gacgagtgtg ccgaggtcgg ggcggtgcac ctggacgccg tcggcgtcga gggccgcggt
    23701 gatgcgctcg gcgaggttgt ccatgacgac ggtggcaccg ccggtcgccg cggagctctc
    23761 ccgggccagg gcgcgggtca gcgcctgccg ggcgccgggc tgggccgata cggcgccggc
    23821 cagcgcggcg gcctcgaaac gcgggtcggt gagaccgagg cgcagcgcgt ggaggtggcc
    23881 cacgaagcgg gcgtcgacga tcgcgacccg ctggttcgcc ggcacggcgg cgaggagcgt
    23941 ctctgcgtca ccggcgtcgg aggcgacccg cacgtcgaag ccgagcgacc gcagatcgcc
    24001 ttcgagcgac gatccgggga ccggctgacc ggtgaggatg gcggtcgaca gacgaactca
    24061 ctccctgggt gttgacgcgt gctcgcgccg ggcgtgtgcg tgatgggggg cacccctggc
    24121 cgtcgaaggc ggccgggcgg cgtgtcggca gaggctatcg gatgatgaga agcgggcgtt
    24181 caccggccgt tcacggcccg atcaacccgg tctggtcgac cgcctccgcc gcgatcatca
    24241 tcggggattt ctgggccggg ccacaaaccg cggccccaga tcccctcatt caagacgtcg
    24301 aagcaccgta cacaccatcc cggaacctgg cattccaggc agcgcgcggg gtcgtgccgg
    24361 agccgaccgg catagggtgg gcgtccatga catggctgat caccggcggg gccggataca
    24421 tcggtgcaca tgtggcgtgg gcgatgacgg aggccgggga gcgtgtgctc gtcctcgacg
    24481 acctctcggc cggggtgccg gaccggctcc ccacgagcat tccgctggtg cagggctcct
    24541 ccctggacgg ggcgctgctg aagcgggtct tcgccgagca ctccgtgaca ggtgtggtgc
    24601 atctcgcggc gcgcaagcag gtcggcgagt ccgtggcgca gccgacgcgc tactaccagg
    24661 agaacgtggg cggtctcacg accctcctcg acgcggtggc cggagcgggc atccagcgat
    24721 tcctgttctc gtcgtcggcg gcggtctacg gcaaccccga tgtggacctc atcacggagg
    24781 acactccctg tgcgccggtg aacccgtacg gcgagaccaa gctcgccggt gagtggctgg
    24841 tgcgggcggc gggccgggcg cacggtatct cgaccgtatg tctgcgctac ttcaacgtgg
    24901 ccggcgcggc ctcgcccgag ctggccgaca cgggcgtctt caacgtcgtc cccatggtct
    24961 tcgaccgtct cacccgcggc gaggccccga ggatcttcgg cgacgactat ccgacgtccg
    25021 acggcacctg tgtacgtgac tacatccacg tcgccgacct ggccgacgcg catctcgcgg
    25081 cggcacggcg gctgaccgcc ggcgccacgg gcgacctgac cgtgaacatc ggccgcggcg
    25141 aaggtgtctc ggtgcgcgag ctcatcacgc tgatcggcga ggtgagcggc gacaccaccc
    25201 ccgccctcgt ggagccgcgc cgtcccggtg acgccccgcg cgcggtcgcg tcggccgcgc
    25261 tggccgccga ggagctgggc tggcacgccc ggcggggggt gcgcgagatg gtggagtcgg
    25321 cgtggcgggg ctggcgccat caccaccccg aagcggcgcg cggatagcca acccgcgtga
    25381 ggagccaacc cgcgtgaggt gcggatagcc acacccgcgt gaggtagggg ggacccgcac
    25441 gtgaggtagg gggtacgcgc gcacgcgcac gcgacgtacg gggggcgtgc aggcgaagcg
    25501 gggcgcgggc tcgtgcgcgg tcgcccggag tgtcgacacg ggcgattccc ggtgcgcggc
    25561 accgggcacg atcaggtatc cggccgctcc cggagtccgc tcgggaccgg ccgcacgggc
    25621 cgttccgggg caccggggtg ggacatgcgg gaagtcgcga agtgccggga gtgccggatt
    25681 cgtacggcag acttgggctg gaagaccgat gcgaaggatg ggtatgccga tcacacctgc
    25741 cacctcgacg cacagttcgt cgaacggcac cgctgaagcg atcttgctgg agctggtcga
    25801 cgagaacggc actacgatcg gcacggcgga gaagctcgcc gcccatcagc cgcccgggca
    25861 gctgcaccgg gcgttctccg tgttcctctt cgacgagcag ggccggctgc tgctgcaaca
    25921 gcgcgccctg ggcaagtacc actcccccgg cgtctggtcg aacacctgct gcggccaccc
    25981 ctacccgggc gaggcgccct tcgcggcggc cgcccggcgg acccacgagg agctcggggt
    26041 ctccccctcg ctgctcgccg aggcgggcac ggtccgctac aaccacccgg acccggactc
    26101 ggggctggtc gagcaggagt tcaaccacct cttcgtcggg ctggtgcagt ccccgttgcg
    26161 ccccgacgcc gaggaaatcg gcgacacggc cttcgtcacc gccgccgaac tggcggagcg
    26221 gcacgcgaag gacccgttct cctcatggtt catgaccgtc ctggacgcgg cccgtccggc
    26281 ggtccgggag ctgacgggcc cgtccgcggg ctggtgagcc gccgtaccgc ggcggacggg
    26341 aacacaccgg cggaccagca catgccgacg ggccagaaca tgcccacggg ctagaacatg
    26401 ccgacgggct tgagcggcac ggccgcccag atcaccttgc cgccgctcgc cgtgtgctcc
    26461 acgtcgcaca ccccgcccgc ctccctggtg atctcccgca ccagaagcag tccgcgtccg
    26521 ccggtctgcc cgtggtcggc ctccagggcg gtggggcggt aggggtggtt gtcctccacg
    26581 gagatccgca gccagtcggc cccgacggcg acctccaccg ccagcatcgg tgacagcagc
    26641 gccgcgtgcc tgacgg
//
