LOCUS       NC_003155              22735 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1407490
            Orig. end                         :: 1430225
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22735
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /product="melanin"
                     /region_number="9"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..22735
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /detection_rules="melC"
                     /kind="neighbouring"
                     /product="terpene-precursor"
                     /product="melanin"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21035
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21035
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11035](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11035)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            224..2467
                     /db_xref="GeneID:41538228"
                     /locus_tag="SAVERM_RS06100"
                     /old_locus_tag="SAV_1122"
                     /old_locus_tag="SAVERM_1122"
     CDS             224..2467
                     /codon_start=1
                     /db_xref="GeneID:41538228"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS06100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_1122"
                     /old_locus_tag="SAVERM_1122"
                     /product="hypothetical protein"
                     /protein_id="WP_010982560.1"
                     /transl_table=11
                     /translation="MSTASGDPTTGTADFFAAPLADASLPEEWESGQQAVTEQATNPAS
                     GTDEMSAPEEQVTRTSATPLPGAPNGAAALPYRPTRGRYRSSGGGFHLELRVDVDSTAG
                     GPKVLNRISGDFFSTSGATTTYYGSLVVHAPTVTRSATQVVISGLGTYTWQAGAPIVRV
                     TIPRRRINQPQGTATVQFLTTSNQPGAGYTCGYVSPYFRTVQWEQDSVTGRIPFLSYDT
                     GSLPQPPNSPARALTVPRAYAEAGIELLMSGTANTIADSPGGWTNTELHGAMQTNFSLW
                     RDAPQWKVWLLVAGSYEGMAGVRGIMFDAADSFQRQGCAVFYDLIKGTDAESQRAQLRT
                     YVHELGHSFNLLHSWQKNLAQPPAPLGPQNGFGDLSWMNYPQNYLPPTGTGGAAAYWGA
                     FPFQFTDNELVHLRHGFYRDVVMGANAFGIGAADIEPELFDEPLADESGLRLDLRVTKS
                     GFAFGEPVVVELKLDTTDLRGRSTHDHLHPDDELVHIAIRQPSGRTVLYRPLLRRCVDQ
                     DATVRLDTDRPAIYSSAYIGYGRDGHYFQQPGTYQLRASYLASDGSRIVSPVLRLHVRH
                     PVSQSDIELAELMMGEEQGTILALRGSDSPSLQAGNDALQEVIERHANHPFAVYARLAK
                     GLNFEHEFKSLSPDKAGLNVRPPDTKSGIEQLSQVVKVSEQGKGVDNLTLNLATRRLAR
                     AYARQGDLEEAGSTLDRLVRHFDTPAFKPYVVDAVRSQADSTKARLLAEFGDS"
     gene            2569..3081
                     /db_xref="GeneID:41538229"
                     /locus_tag="SAVERM_RS06105"
                     /old_locus_tag="SAV_1123"
                     /old_locus_tag="SAVERM_1123"
     CDS             2569..3081
                     /codon_start=1
                     /db_xref="GeneID:41538229"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS06105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_1123"
                     /old_locus_tag="SAVERM_1123"
                     /product="hypothetical protein"
                     /protein_id="WP_037650205.1"
                     /transl_table=11
                     /translation="MLDLVLYGPQGPQPLGGSAPVRAKVRNSGERAVWIAGVLDGSEDG
                     IRFPHYLPAVTLADGGRTVARPGPAEDPLVGPLRVGHLLRLAPGESFDPTAGAGCLPLT
                     TFAAFAPQAPGRYRYTLTLSTEAGRPEEWLGGFGLPSGAEREELLDLIARVPRITVSAA
                     PLILEFR"
     gene            complement(3103..3939)
                     /db_xref="GeneID:41538230"
                     /locus_tag="SAVERM_RS06110"
                     /old_locus_tag="SAV_1124"
                     /old_locus_tag="SAVERM_1124"
     CDS             complement(3103..3939)
                     /codon_start=1
                     /db_xref="GeneID:41538230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983179.1"
                     /locus_tag="SAVERM_RS06110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1124"
                     /old_locus_tag="SAVERM_1124"
                     /product="cache domain-containing protein"
                     /protein_id="WP_010982562.1"
                     /transl_table=11
                     /translation="MPHSIPQPGLSFCLAAHPVPAPAGSGRPATATLDVSPQARVAAQV
                     RSALEAVFEAVEETRADTAALLAQVAGLGRRPATVDLAGLRPGLHLRLARQELVSGVGF
                     VAAPGLLGDVPTWLEWWQTGADGALRPLLLDLDPRQSAYSDYTHWDWFALPRDTGRRAV
                     AGPYVDYLCSEEYSLTLSAPVQVEGRFAGVAAADVYLRHFETAVMPLLQRLPGPAHLVN
                     ARGRVAASADPAHLAGSLTKGPDFAAVLTQARPEHFDGLHLMPCDGVPLVLVMAER"
     gene            4253..5455
                     /db_xref="GeneID:41538231"
                     /locus_tag="SAVERM_RS06115"
                     /old_locus_tag="SAV_1125"
                     /old_locus_tag="SAVERM_1125"
     CDS             4253..5455
                     /codon_start=1
                     /db_xref="GeneID:41538231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676845.1"
                     /locus_tag="SAVERM_RS06115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1125"
                     /old_locus_tag="SAVERM_1125"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_037646140.1"
                     /transl_table=11
                     /translation="MRLHRSFKAAAAAGALLLVSGCGLFTESDASSSAYGLNPPDLKAQ
                     SKLGKTEGQVNLIAWAGYVEDGSNDPKADWVSSFEQRTGCQVKSKVAASSDEMVKLMKT
                     GNYDAVSASGDASLRLIASGDAAPVNTDLVPNYQDVFFGLKKQAWNSFDGQPYGIPHGR
                     GANLLMYNTQQVKPAPTSWSAVFDDASPHKGHVTAYDSPIYIADAALYLRETQPGLNIE
                     NPYALDQDQFDAAVALLKDQNANVGEYWSDYLKEVSAFKSGDSTVGTTWQVIANLAADE
                     GAKVKAVLPIEGATGWSDTWMISAKAKHPNCAYKWMNWIISPKVNAEVAEYYGEAPSNI
                     KACDEISDDAFCDTYHATDEGYWKDIAFWTTPIEQCLDGRTEVKCVPYAKWVQAWTEIK
                     G"
     gene            complement(5479..6975)
                     /db_xref="GeneID:41538232"
                     /locus_tag="SAVERM_RS06120"
                     /old_locus_tag="SAV_1126"
                     /old_locus_tag="SAVERM_1126"
     CDS             complement(5479..6975)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538232"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079696.1"
                     /locus_tag="SAVERM_RS06120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1126"
                     /old_locus_tag="SAVERM_1126"
                     /product="FGGY-family carbohydrate kinase"
                     /protein_id="WP_010982564.1"
                     /transl_table=11
                     /translation="MRKRERGTVLGVDIGTSSSKGVLVDQDGTVLATAVRPHTVSRPRP
                     GHVELDARVWWDEFASLARELTGRGSEVTAVGVSGMGPCVALTDEADTPLHPAILYGVD
                     TRATEQIARLEAELGREAVLERCGSLLSTQAVGPKIAWLAEHAPDVIARARRLYMPSSY
                     LVRRLTGAYVLDHHSASQSVPLYDSVAQEWYAPWARHIAPWIELPRLGWPGDIAGHLTA
                     EAAATTGLPAGVPVVTGTIDAWSEALSVGAQCTGDLMLMYGSTMFLINTVTERLLVPQL
                     WSTVGALPGTRNLAGGMATSGVITDWLRELFGGPEHSALLAEAEAAGPGAKGLLMLPYF
                     AGERTPVADPDARGVIAGLTVEHTRGDLYRAALEATAFGVRHNAEAMRAAGADVHRVVA
                     VGGGTRGGLWTRIVSDVTGLEQEIRTVTLGASYGAAFLAAQAVGDADIDAWNPVREQVA
                     PDARLRPRYDDLYDLYLRLYPATRDIGHALARQQRDIAAS"
     gene            7145..7822
                     /db_xref="GeneID:41538233"
                     /locus_tag="SAVERM_RS06125"
                     /old_locus_tag="SAV_1127"
                     /old_locus_tag="SAVERM_1127"
     CDS             7145..7822
                     /codon_start=1
                     /db_xref="GeneID:41538233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433207.1"
                     /locus_tag="SAVERM_RS06125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1127"
                     /old_locus_tag="SAVERM_1127"
                     /product="AIM24 family protein"
                     /protein_id="WP_010982565.1"
                     /transl_table=11
                     /translation="MKGDLFSSDHMVEPAVAPGMTVQNAKSIKYAVNGDMLARQGAMIA
                     YRGNLQFERKGQGVGGMLKRAVTGEGLPLMTVRGQGEAWFAHEAQNCFVVGIEPGDVFT
                     VNGRNVLCFDSTLTYEIKTVKGAGISGGGLFNSVFTGHGKLGLICEGNPLVIPVSQQQP
                     VYVDTDAVVGWTAHLHTSLHRSQSIGSMLRGGSGEAVQLKLEGDGYVVVRPSEATPQKV
                     QQH"
     gene            complement(7888..9672)
                     /db_xref="GeneID:41538234"
                     /locus_tag="SAVERM_RS06130"
                     /old_locus_tag="SAV_1128"
                     /old_locus_tag="SAVERM_1128"
     CDS             complement(7888..9672)
                     /codon_start=1
                     /db_xref="GeneID:41538234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069211.1"
                     /locus_tag="SAVERM_RS06130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1128"
                     /old_locus_tag="SAVERM_1128"
                     /product="M4 family metallopeptidase"
                     /protein_id="WP_010982566.1"
                     /transl_table=11
                     /translation="MRRPHIRGVAIAIAVTTAATLPAVPAVADAPALAAAAASSPVDAA
                     RAAAFAHASATGVSRGDTLEAKDVLTDPDGKQHVRFVRTHQGLPVLGGDLVVHLTKRST
                     YLGVTRAADHTVKPAAAGQAKLTPAQAEQKAAAAAQGDATEAALVVDARDGGSALAYQV
                     RVTDSKTTEATGSRTVVVDAVTGRIRSNTPDSDEFISPSLAQTLRERGETANPATGTAD
                     SALTGSSLLTGISGAASYPRKASGTGTSLFVGKVGLSTTQTARTSFLLKDSTRWGTETR
                     DAKGQYLEAFSRGKKFTDKNNKWGTGKTSSRQSAAVDAQYGVTKTLDFYKKTFGRKGIK
                     NNSTGARAMVHFGTKVGNAFWDSACGCMLYGDGDGDLFKKPLVVLDVTGHELTHGVVDA
                     TAALEPTRVDRDGNQFGEPGSLNESLADIFGTGMEFATNNSKDAGDYLVGEKLGLDQKF
                     LRRLDEPSRDKLEGTIDYWSPETYDTEVHAGSGVSSHAFYLLAEGSGRKTIGGVKYNSP
                     TSDGSTVTGIGRAKALAIFYRALTRYMVSTTDFHDARNATLKAATDMYGADSIEYQTVD
                     KAWAGVNVTSANTPSTGR"
     misc_feature    complement(9824..9840)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.39"
                     /tool="antismash"
     misc_feature    complement(9829..9842)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.86"
                     /tool="antismash"
     misc_feature    9833..9848
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.85"
                     /tool="antismash"
     misc_feature    complement(9943..9958)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     gene            complement(10001..11035)
                     /db_xref="GeneID:41538235"
                     /locus_tag="SAVERM_RS06135"
                     /old_locus_tag="SAV_1129"
                     /old_locus_tag="SAVERM_1129"
     CDS             complement(10001..11035)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538235"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998436.1"
                     /locus_tag="SAVERM_RS06135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1129"
                     /old_locus_tag="SAVERM_1129"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_010982567.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.7e-66, bitscore:
                     221.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLTTALKAGPEAPAILHRCRELVAPALAEAVGGMHPWMREMAD
                     YALGRGAAGGAPAAHSQGKGVRQALAVLGAEAAGGPAEAGVPAAVAVELVHTFSLLHDD
                     IMDGDAMRRGRPALWKAYGTGPAVLAGDALFALAVQTLTTASAPGAAHRLSAALGDLVR
                     GQADDLLFAHRPWTGPEAVSVAEYEAMAEHKTGSLLGCALALGAHLAGAPEETAAVLDR
                     TGRHLGVAFQIVDDLLGIWGDPAVTGKPVHGDLRQGKKTFPVLAALATPSGSALEGLLT
                     ARDDTAVVRAAAVVEQAGGRSAALREARRHLTVAHGLLASVQPAPRPAADLRTLLSALS
                     RRTI"
     gene            complement(11032..12090)
                     /db_xref="GeneID:41538236"
                     /locus_tag="SAVERM_RS06140"
                     /old_locus_tag="SAV_1130"
                     /old_locus_tag="SAVERM_1130"
     CDS             complement(11032..12090)
                     /codon_start=1
                     /db_xref="GeneID:41538236"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117960.1"
                     /locus_tag="SAVERM_RS06140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1130"
                     /old_locus_tag="SAVERM_1130"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_010982568.1"
                     /transl_table=11
                     /translation="MYGKAFAPEYQGALTTLSVNSSLTDVLAAGTEQLRAAERAGARGE
                     AARSGLAVAEAHRRLGQVADAERAWKASYRTAREAGDTGAMAWALWSGGTLARQRGALP
                     LAWRLLRLAAELGKHAGDVVVRGYSLAGMAETGRIQGDYEAVTTLHEQLLAEARKRGEA
                     RHTVWALEGIAQIHRNTGSYDTAYAMFEEAAAIAAGAEDRRGHAWALRGLADIVSVRDR
                     DPERALALLGEAEVSCREMNLVSALAYNHKMRGNVLYRAGRYAEAREVYAQALAEFDGM
                     SEPRGRALARLGLVKSLARLGRDRAETGAELDELVGVLDGIGLRHGRELIRGAREELGL
                     APRSSAGREAGR"
     misc_feature    12367..12381
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     cand_cluster    12379..22735
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    12379..22735
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[17378:17735](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      17379..17735
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="2"
     misc_feature    complement(12382..12396)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(12382..12397)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.33"
                     /tool="antismash"
     misc_feature    12383..12396
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.77"
                     /tool="antismash"
     gene            12419..13045
                     /db_xref="GeneID:41538237"
                     /locus_tag="SAVERM_RS06145"
                     /old_locus_tag="SAV_1131"
                     /old_locus_tag="SAVERM_1131"
     CDS             12419..13045
                     /codon_start=1
                     /db_xref="GeneID:41538237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526757.1"
                     /locus_tag="SAVERM_RS06145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1131"
                     /old_locus_tag="SAVERM_1131"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_010982569.1"
                     /transl_table=11
                     /translation="MSTHLQGSLFDQTDELGLGPLDGLRRTVLGAGAWIDLLPGWLSGA
                     DALFERLAADVPWRAERRKMYDQTVDVPRLLAYYRAGDTLPHPVLAEARDALSAHYVAE
                     LGEPFTTAGLCYYRDGRDSVAWHGDRIGRGAREDTMVAILSVGAPRDLALRPRGGGDVL
                     RRPLGHGDLIVMGGSCQRTWEHAIPKSTRAAGPRISIQFRPSGVN"
     gene            complement(13058..13654)
                     /db_xref="GeneID:41538238"
                     /locus_tag="SAVERM_RS06150"
                     /old_locus_tag="SAV_1132"
                     /old_locus_tag="SAVERM_1132"
     CDS             complement(13058..13654)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538238"
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117972.1"
                     /locus_tag="SAVERM_RS06150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1132"
                     /old_locus_tag="SAVERM_1132"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_037646136.1"
                     /transl_table=11
                     /translation="MSTMTTPSAATPPAAAPARRDAEATKAAILRAARHLLARHAHADI
                     TLKAVADRAGVSPPLILKYFGNKDALFARVMSFEADVPDLLDAPLDDLGRHMVRHVLVG
                     QTERGADPVLRIVFAPLQGEQGDILRANFRAQVGDRLAERLAGPDAGLRAELAVSALLG
                     LGVMFGIARGTHLRAAAIDDIVDRYAPAVQMHLTP"
     gene            complement(13651..15153)
                     /db_xref="GeneID:41538239"
                     /locus_tag="SAVERM_RS06155"
                     /old_locus_tag="SAV_1133"
                     /old_locus_tag="SAVERM_1133"
     CDS             complement(13651..15153)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538239"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057092.1"
                     /locus_tag="SAVERM_RS06155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1133"
                     /old_locus_tag="SAVERM_1133"
                     /product="MFS transporter"
                     /protein_id="WP_037646133.1"
                     /transl_table=11
                     /translation="MVPISTPSDRSATPDGPAGRPGVRDRLTVPVLAFGGILMAVMQTV
                     VVPLLPDLPRLTGASAGAVSWMVTATLLSGAVLTPVLGRAGDMYGKRRVLLAALALMTL
                     GSLLCAVTSDIRVLIAARALQGAAAAVVPLSISILRDELPPERTGSAVALMSSTVGIGA
                     ALGLPIAAMIVQYADWHVMFWATTGLGAGGLALAWWAVRESPVRQPGRFDTLGALGLAA
                     GLVCLLLGVSQGGQWGWTSPRIVGLLVACVLVLTLWWFQQWRAPRPLVDLKLASRPRVA
                     LPHVAALLTGFAFYGNSLVTAQLVQAPKATGYGLGLSIVQTGLCLLPGGVIMLLFSPVS
                     ARISAARGPRVTLALGAAVIAVGYAVRIADSRDLWMIIVGATVIAVGTTLAYSALPTLI
                     LRAVPAGQTASANGVNVLMRTIGQAVCSAAVAAVLVHHTSLVGGAPVPTLHGYLLAFAM
                     AGTVAVMACAAALVIPGDPDSHGTRRARGRTRPSHDEALEGA"
     misc_feature    complement(15218..15231)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.19"
                     /tool="antismash"
     gene            complement(15271..16476)
                     /db_xref="GeneID:41538240"
                     /locus_tag="SAVERM_RS06160"
                     /old_locus_tag="SAV_1134"
                     /old_locus_tag="SAVERM_1134"
     CDS             complement(15271..16476)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538240"
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474270.1"
                     /locus_tag="SAVERM_RS06160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1134"
                     /old_locus_tag="SAVERM_1134"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_010982572.1"
                     /transl_table=11
                     /translation="MKIACVGGGPASLYFSILMKRQDPSHDITVHERNPAGSTYGWGVT
                     YWSGLLDKLRGSDPESALAVSENSVRWSDGVAHVRNRTTVHHGDEGFGIGRRRFLDVLA
                     DRARSLGVRIEYEHEIGADDPLPEADLVVAGDGVNSVLRGRYADHFGSETVLGRNRYIW
                     LGTTKVFDSFTFAFVESEHGWIWCYGYGFSDGHSTCVIECSPETWTGLGLDRASEADGL
                     ALLEKLFADVLDGHELIGRAQSDGAAQWLNFRTLTNRTWHRDNLVLIGDAAHTTHYSIG
                     AGTTLALEDAIALAEALSAHRDLPGALAAYERERKSALLHIQSAARLSAQWYENLPRYI
                     RLPPPQMFALLGQRHSPLLPYVPPQLYYRIDRAAGQLEALRRLKRWLGPRLARTVQART
                     GR"
     gene            16630..17097
                     /db_xref="GeneID:41538241"
                     /locus_tag="SAVERM_RS06165"
                     /old_locus_tag="SAV_1135"
                     /old_locus_tag="SAVERM_1135"
     CDS             16630..17097
                     /codon_start=1
                     /db_xref="GeneID:41538241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562541.1"
                     /locus_tag="SAVERM_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1135"
                     /old_locus_tag="SAVERM_1135"
                     /product="hypothetical protein"
                     /protein_id="WP_010982573.1"
                     /transl_table=11
                     /translation="MTHPPAGPVLAALVSRATGGRYWRLDRPGAGLDAEAMHIPPGAAA
                     EPPGDRSRDVLVIALDGGGRLRTPGGWLELAPPAAVWLPPAAGYRLHAGEAGLHCVTVR
                     PRRPAAPPALPTTGATGEPACLLHQVCAECGRMATESDARYCNRCGNPLER"
     gene            17379..17735
                     /db_xref="GeneID:41538242"
                     /locus_tag="SAVERM_RS06170"
                     /old_locus_tag="SAV_1136"
                     /old_locus_tag="SAVERM_1136"
     CDS             17379..17735
                     /codon_start=1
                     /db_xref="GeneID:41538242"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474271.1"
                     /locus_tag="SAVERM_RS06170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1136"
                     /old_locus_tag="SAVERM_1136"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_010982574.1"
                     /sec_met_domain="melC (E-value: 1.7e-47, bitscore: 160.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELTRRHALGAAAALAAVAGTQALAAPSASAAGHHGGPQPFDEV
                     YQGRRIEGRATGGGHHHGSGYGVFIDGMELHVMQNVDGSWISVVSHYDPVATPRAAARA
                     AVVELQGAPLVPFN"
     gene            17771..18595
                     /db_xref="GeneID:41538243"
                     /locus_tag="SAVERM_RS06175"
                     /old_locus_tag="SAV_1137"
                     /old_locus_tag="SAVERM_1137"
     CDS             17771..18595
                     /codon_start=1
                     /db_xref="GeneID:41538243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126207.1"
                     /locus_tag="SAVERM_RS06175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1137"
                     /old_locus_tag="SAVERM_1137"
                     /product="tyrosinase family protein"
                     /protein_id="WP_010982575.1"
                     /transl_table=11
                     /translation="MTVRKNQATLTADEKRRFVDALVALKRSGRYDEFVTTHNAFIMGD
                     TDSGERTGHRSPSFLPWHRRFLIEFEQALQAVDPSVALPYWDWSTDRTARASLWAPDFL
                     GGSGRSLDGRVMDGPFAASTGNWPVNVRVDSRTYLRRTLGGGGRELPTRAEVDSVLAMS
                     TYDMAPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAYIDRL
                     WAQWQSRHPGSGYVPTGGTPNVVDLNETMKPWNDVRPADLLDHTAHYTFDTV"
     gene            complement(18737..19447)
                     /db_xref="GeneID:41538244"
                     /locus_tag="SAVERM_RS06180"
                     /old_locus_tag="SAV_1138"
                     /old_locus_tag="SAVERM_1138"
     CDS             complement(18737..19447)
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003967.1"
                     /locus_tag="SAVERM_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1138"
                     /old_locus_tag="SAVERM_1138"
                     /product="ribonuclease H"
                     /protein_id="WP_010982576.1"
                     /transl_table=11
                     /translation="MIGGMSERVVAACDGASKGNPGPAGWAWVVADGEETPTRWAAGAL
                     GTATNNVAELTALERLLSAMDPDVPLEIRMDSQYAMKAVTTWLPGWKRKGWKTAAGKPV
                     ANQELVARIDELLDGRSVEFRYVPAHQVDGDRLNDFADRAASQAAIVQEPAGSEYGSPE
                     PPKSPDTVAAGSAGRGAPAKKRASARTAKTSTRTIKAKFPGRCVCGRPYAAGEPIAKNA
                     QGWGHPECRTADDV"
     gene            19656..20147
                     /db_xref="GeneID:41538245"
                     /locus_tag="SAVERM_RS06185"
                     /old_locus_tag="SAV_1139"
                     /old_locus_tag="SAVERM_1139"
     CDS             19656..20147
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125231.1"
                     /locus_tag="SAVERM_RS06185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1139"
                     /old_locus_tag="SAVERM_1139"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_010982577.1"
                     /transl_table=11
                     /translation="MKPLTGSTTDQAPADPAATDDVLATQPIGYWSGLAHTAVTRQLRD
                     AMARIDVTQPQYWVLNRVHGGPAAPGREEVVTQLTPLADGPHEIARVVDQLLHRGWLRI
                     DAGQRLRLTDTGEAARKRLRELVTELRAVVHEGISDEEYVTALKVLRTMIANVEGDAGC
                     "
     misc_feature    19658..19669
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.54"
                     /tool="antismash"
     gene            complement(20227..21024)
                     /db_xref="GeneID:41538246"
                     /locus_tag="SAVERM_RS06190"
                     /old_locus_tag="SAV_1140"
                     /old_locus_tag="SAVERM_1140"
     CDS             complement(20227..21024)
                     /codon_start=1
                     /db_xref="GeneID:41538246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031563.1"
                     /locus_tag="SAVERM_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1140"
                     /old_locus_tag="SAVERM_1140"
                     /product="VOC family protein"
                     /protein_id="WP_010982578.1"
                     /transl_table=11
                     /translation="MAVYPEGKPCWADAMFSDVEGAKTFYGDVLGWTFGESSSEYGNYT
                     QAYADGKAVAAVVPPMPGQEGHSAWCLYFASPDAAATARKIRDNGGEVLMEPMQVGDFG
                     TMALAREPSGAVFGVWQPGVHKGFEATAVPGAYCWAEVFTREPEKPDAFFPAVFPLTAQ
                     QIEDEAVDFRIFSVGEDAVLGRMKMTDDFPPEVPSFINVYFTVEDVDAAVAKATEHGGI
                     LRFGPMDSPFGRFAALSDPQGASFAVIDIKTTQGELPKLTDVS"
     gene            21170..22174
                     /db_xref="GeneID:41538247"
                     /locus_tag="SAVERM_RS06195"
                     /old_locus_tag="SAV_1141"
                     /old_locus_tag="SAVERM_1141"
     CDS             21170..22174
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004024 - alcohol dehydrogenase activity,
                     zinc-dependent [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006113 - fermentation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538247"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057100.1"
                     /locus_tag="SAVERM_RS06195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1141"
                     /old_locus_tag="SAVERM_1141"
                     /product="zinc-binding alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_010982579.1"
                     /sec_met_domain="ADH_N (E-value: 1.8e-29, bitscore: 100.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWAWEVERPGPIEDGPLRFVERPVPVPGPGELLVRVRACGVCRTD
                     LHVSEGDLPVHRPRVTPGHEVVGVVAGRGADAGGYAVGDRVGVAWLRRTDGTCRYCVRG
                     AENLCPASEYTGWDTDGGYAEYTTVPAAFAYRLPTDVDDVALAPLLCAGIIGYRALVRA
                     SLPPGGRLGLYGFGGSAHLCAQVALAQGATVHVLTRDPASQRLALALGAASAGGAYDTP
                     PEPLDSAILFAPAGGLVPVALRALDRGGVLSVAGIHLSDTPPLCYERELFYEKELRSVT
                     SNTRADGREFLELAARYGVRATTHTYPLSEAQQALRDLKAGRFDGAAVLVNDV"
ORIGIN
        1 ccgcgggtgg aaactcctga gtcctcggtg aattccggaa tccaccgtgc ctgggtgaaa
       61 cgaattccgg cgtatttctt cggcaccttc gaaacgatcg ttgacgcaac cgtggtgcgg
      121 tgcaaacgtc gcaccagtcc tcccggccgg ccgggacccg gggcgacgcc aggcgggcgt
      181 cgcccacaaa cggcgaactc aggcgaacgg aggacctctc gcgatgtcaa cagccagcgg
      241 agacccgaca acagggacgg ccgacttctt tgcggcgccc ctggcggatg cctcgctccc
      301 cgaggagtgg gagagcggcc aacaggcggt caccgagcag gccaccaatc cggcgagcgg
      361 caccgacgag atgtcggcgc ccgaagagca ggtcacaagg acatccgcga caccactgcc
      421 cggcgcaccg aacggcgccg ccgcgctccc ctaccgtccc acccgcggcc gctaccgcag
      481 cagcggcggc ggcttccacc tggagttgcg ggtcgacgtc gacagcacgg cgggcggccc
      541 gaaggtcctc aacaggatca gcggggactt cttcagcacc agcggcgcca cgacgacgta
      601 ctacgggtcg ttggtcgtgc acgcgcccac cgtcacccgg tccgccaccc aggtggtcat
      661 cagcggcctg ggcacctaca cctggcaggc cggcgccccg atcgtccggg tgaccattcc
      721 gcggcgccgg atcaaccagc cgcagggcac cgccaccgtg cagttcctca ccacctccaa
      781 ccagcccggc gccggctaca cctgcgggta cgtctccccg tacttccgca ccgtccagtg
      841 ggagcaggac tcggtcaccg gcaggattcc gttcctctcc tacgacaccg ggtcgctccc
      901 gcagccgccg aacagtcccg cccgggcgct caccgtgccc cgcgcgtacg ccgaggccgg
      961 tatcgagctg ctcatgtccg gcaccgccaa caccatcgcc gacagcccgg gcggctggac
     1021 caacaccgaa ctgcacggcg ccatgcagac caacttcagc ctgtggcgcg acgccccgca
     1081 gtggaaggtg tggctgctgg tagccggcag ctacgaaggc atggcggggg tgcgcggcat
     1141 catgttcgac gccgccgact ccttccagcg gcagggctgc gcggtcttct acgacctgat
     1201 caagggcacc gacgccgagt cgcagcgcgc ccagctgcgc acgtacgtcc atgaactcgg
     1261 ccactccttc aacctgctgc actcctggca gaagaacctg gcgcagccgc cggcgccgct
     1321 cggtccgcag aacggcttcg gcgatctgtc ctggatgaac tacccgcaga actacctgcc
     1381 gccgacgggc accggcgggg cggccgcgta ctggggcgcc ttcccgttcc agttcacgga
     1441 caacgagctg gtccacctgc ggcacggctt ctaccgcgac gtcgtcatgg gggccaacgc
     1501 cttcggtatc ggtgccgccg acatcgaacc ggaactgttc gacgagcccc tcgccgacga
     1561 gtccgggctg cgcctggacc tgcgggtcac caagagcggc ttcgcgttcg gcgaacccgt
     1621 cgtcgtggag ctgaagctgg acacgacgga cctgcgcggc cgctccaccc acgaccacct
     1681 ccacccggac gacgaactcg tccacatcgc catccggcag ccctccgggc gtaccgtgct
     1741 ctaccggccg ctgctgcgcc gctgcgtcga ccaggacgcg accgtacgtc tggacaccga
     1801 ccggccggcg atctacagca gcgcctacat cggctacggc cgcgacgggc actacttcca
     1861 gcagcccggc acctatcagc tgcgcgcctc ctatctggcg tccgacggct cccggatcgt
     1921 ctcgccggtg ctgcgtctcc acgtccggca ccccgtcagc cagagcgaca tcgagctcgc
     1981 cgagctgatg atgggtgagg aacagggcac gatcctcgcc ctgcgcggct ccgactcgcc
     2041 gtcgctacaa gccggcaacg acgccctcca ggaggtcatc gagcggcacg ccaaccaccc
     2101 gttcgccgtg tacgcgcggc tcgccaaggg gctcaacttc gagcacgagt tcaagagcct
     2161 gagccccgac aaggccggcc tgaacgtgcg tcccccggac accaagtccg ggatcgagca
     2221 gctcagtcag gtcgtgaagg tctccgagca gggcaagggg gtcgacaacc tgaccctcaa
     2281 cctggccacg cggcgactgg cccgtgccta cgcccgccag ggcgatctgg aagaggccgg
     2341 ctccaccctc gaccgactgg tccggcactt cgacaccccg gcgttcaagc cgtacgtcgt
     2401 ggacgcggtc cgcagtcagg cggactccac gaaggcccgg ctgctggccg agttcggcga
     2461 cagctgagcc gcgggacgaa ggccgcgcac gggcgcgcga cgcccgtgcg cggcctctgt
     2521 ggcagcatcg cgtacaggcc ccggaccggg gcggggaagg agccggacgt gctcgatctc
     2581 gtcctgtacg ggccccaggg gccgcagccg ctcggcggtt ccgcgccggt ccgggcgaag
     2641 gtgcggaact cgggtgaacg tgctgtgtgg atcgccgggg tgctcgacgg gtccgaggac
     2701 ggcatccgct ttccgcacta tctccccgcc gtcaccctcg ccgacggcgg acgcaccgtc
     2761 gcccggcccg gcccggccga ggacccgctc gtcgggccgt tgcgggtggg ccatctgctt
     2821 cggctggcgc ccggggagtc gttcgatccc acggccggtg ccgggtgcct gccgctgacg
     2881 accttcgccg cgttcgcccc ccaagccccc ggccgctacc ggtacacgct caccctctcc
     2941 accgaggcgg ggcgtcccga ggagtggctg ggcggtttcg gtctgccgtc cggggccgag
     3001 cgggaggaat tgctggacct gatcgcgcgg gtcccccgga tcaccgtgtc ggccgctccg
     3061 ctgatcctgg agttccgctg agcaccggca cttcgaggtc gttcaccgct cggccatgac
     3121 gaggacgagg gggacgccgt cgcagggcat caggtgcagg ccgtcgaagt gttccggccg
     3181 ggcctgggtg aggacggcgg cgaagtcggg gcccttggtg agggagccgg ccaggtgtgc
     3241 ggggtcggcg gaggcggcga cccggccgcg cgcgttgacc aggtgcgccg ggcccggcag
     3301 ccgttgcagc aggggcatca cggccgtctc gaagtgccgc agatacacat ccgccgcggc
     3361 cacccccgcg aaccgcccct ccacctgcac cggcgcggac agggtgaggc tgtactcctc
     3421 ggaacacaga tagtccacat acggcccggc caccgcccgg cgcccggtgt cacggggcag
     3481 cgcgaaccag tcccagtgcg tgtaatccga gtacgccgac tgccgcgggt ccaggtcgag
     3541 cagcaacggc cgcagcgccc cgtccgcacc ggtctgccac cactccagcc acgtcggcac
     3601 atcgcccagc agccccggcg cggccacgaa ccccaccccc gagaccagct cctgccgcgc
     3661 cagccgcaga tgaagccccg gccgcagccc ggccagatcc acggtcgccg gccgacgacc
     3721 cagcccggcc acttgcgcca gcaacgccgc cgtgtccgcc cgcgtctcct cgacggcctc
     3781 gaacaccgcc tccagcgcgg aacgcacctg cgccgccacc cgcgcctgcg gcgacacatc
     3841 cagcgtcgcc gttgccgggc ggccgcttcc cgcgggcgcg ggcaccggat gcgccgcgag
     3901 gcagaacgaa aggccgggct gtggaatcga gtggggcatg accgcgaccg tatacgcaga
     3961 attccctctt ccgcatcttg actgtccgtc aactcctctt caacacagcg cagttgctac
     4021 acatgccgac gctccgtaag gtgtggatca cccgggacgc cggaggacgc cacccgccct
     4081 ccaggcggcc ttgatgctgg gtgcggcccg cctgaaccct ccagcagatc cggagatctc
     4141 gcccgaggac gccactgtga tccgtggcgc cccaacagaa tccggtattc cgtccccttc
     4201 agccccttcc tttcacctct cccccccaca cccacacacc gtggagattt ccttgcgttt
     4261 gcacagatcc ttcaaagccg cggccgcggc cggcgccctg ctgctcgtca gcggctgcgg
     4321 attgttcacg gagtcggacg cctcgtcctc ggcgtacggt ctcaacccgc cggatctcaa
     4381 ggcgcagtcg aagctcggca agaccgaggg ccaggtcaac ctcatcgcct gggccggcta
     4441 cgtcgaggac ggctccaacg accccaaggc cgactgggtc agcagtttcg agcagcggac
     4501 cggctgccag gtcaagtcca aggtcgcggc cagctcggac gagatggtca agctgatgaa
     4561 gacgggcaac tacgacgcgg tctccgcgtc gggcgacgcc tccctgcgtc tcatcgcctc
     4621 cggcgacgcg gctccggtca acaccgacct cgtgcccaac taccaggacg tcttcttcgg
     4681 tctgaagaag caggcctgga actcgttcga cgggcagccg tacgggatcc cgcacggacg
     4741 cggcgccaat ctcctgatgt acaacacgca gcaggtgaag cccgccccga cctcgtggtc
     4801 ggcggtcttc gacgacgcgt cgccccacaa ggggcacgtc acggcgtacg actcgccgat
     4861 ctacatagcg gacgcggccc tgtatctgcg cgagacccag ccgggcctca acatcgagaa
     4921 tccctatgcg ctcgaccagg accagttcga cgccgccgtg gccctgctga aggaccagaa
     4981 cgcgaacgtc ggcgagtact ggagtgacta cctcaaggag gtctccgcct tcaagagcgg
     5041 cgactccacg gtcggcacca cctggcaggt gatcgccaac ctcgccgccg acgaaggcgc
     5101 caaggtcaag gccgtcctgc ccatcgaagg cgccaccggc tggtccgaca cctggatgat
     5161 ctccgccaag gcgaagcacc ccaactgtgc ctacaaatgg atgaactgga tcatctctcc
     5221 gaaggtcaac gccgaggtcg ccgagtacta cggcgaggcg ccgtcgaaca tcaaggcgtg
     5281 cgacgagatc agcgacgacg cgttctgcga cacgtaccac gcgacggacg agggctactg
     5341 gaaggacatc gcgttctgga cgacgccgat cgagcagtgc ctcgacgggc ggacggaagt
     5401 gaaatgcgtg ccttacgcca agtgggtcca ggcctggacc gagatcaagg gctgagcggc
     5461 aaacgcgcgg gcacgcgctc aggaagcggc gatgtcgcgc tgctgccggg cgagcgcgtg
     5521 cccgatgtcc cgggtcgccg gatacaggcg cagatacagg tcgtacaggt cgtcgtagcg
     5581 gggccgtagc cgggcgtcgg gggcgacctg ctcccgtacc ggattccagg cgtcgatgtc
     5641 cgcgtcgccg accgcctgcg cggccaggaa cgcggcgccg tagctcgctc cgagcgtgac
     5701 ggtcctgatc tcctgttcca ggccggtgac gtcggagacg atccgggtcc acagtccgcc
     5761 gcgggttccg ccgccgacgg cgacgacccg gtggacgtcc gcgccggccg cccgcatcgc
     5821 ctcggcgttg tgccggacgc cgaacgcggt cgcctccagc gcggcccggt acagatcgcc
     5881 gcgcgtgtgc tccaccgtca gcccggcgat cacgccgcgg gcgtccgggt cggcgaccgg
     5941 ggtccgctcc cccgcgaagt acggcagcat gagcagcccc ttcgcgccgg gccccgcggc
     6001 ctccgcctcg gcgaggagcg cgctgtgctc ggggccgccg aacaactccc gcagccagtc
     6061 ggtgatcaca ccggaggtcg ccatgccgcc cgcgaggttg cgcgtgccgg gcaacgcgcc
     6121 gacggtgctc cagagttgcg ggaccagcag gcgttcggtc accgtgttga tcaggaacat
     6181 ggtgctgccg tacatgagca tgaggtcccc ggtgcactgg gctcccacgc tcagcgcctc
     6241 cgaccaggcg tcgatcgtgc cggtgacgac ggggacgccc gcgggcagtc cggtggtggc
     6301 ggccgcctcg gcggtgaggt ggccggcgat gtcccccggc cagccgagcc gcggcagttc
     6361 gatccagggc gcgatgtgcc gggcccaggg cgcgtaccac tcctgggcga cggagtcgta
     6421 gagcgggacg gactggctcg cggagtggtg gtcgagcacg tacgccccgg tgagccggcg
     6481 cacgagatac gaactcggca tgtacagccg gcgggcgcgg gcgatgacgt cgggtgcgtg
     6541 ctccgccagc caggcgatct tgggaccgac ggcctgggtg gagagcaggg acccgcagcg
     6601 ttccaggacg gcctcccgcc ccaactcggc ttccagccgg gcgatctgct ccgtcgcacg
     6661 ggtgtcgacg ccgtacagga tcgccgggtg caacggcgtg tcggcctcgt cggtgagggc
     6721 gacacagggg cccatgccgc tgacgccgac cgcggtcacc tcgctgcccc ggccggtcag
     6781 ctcacgggcg agggaggcga actcgtccca ccacacgcgg gcgtccagct ccacgtgccc
     6841 gggtcgtgga cggctgacgg tgtgcggtcg tacggcggtg gcgagcaccg ttccgtcctg
     6901 gtcgacgagg acacccttgc tgctggacgt gccgatgtcg actccgagca ccgtcccacg
     6961 ctcacgcttg cgcacacccg gagcgtaggc gatccgcggc cggttcgccg tgcggcttgt
     7021 cgatgcccgg cagccgcggg gtgaacaccg ggccctcgac cgaagggctc gtgcgcggag
     7081 ttgttgccgt ttccgtacgc ctccgatctt ggcggaggcg tttcctccgg gacaggatgc
     7141 ccgtatgaag ggtgacctgt tttccagtga ccacatggtg gagcccgccg tcgcgccggg
     7201 catgaccgtg cagaacgcca agtccatcaa gtacgccgtg aacggcgaca tgctcgcgcg
     7261 gcagggggcg atgatcgcct atcgcgggaa cctgcagttc gagcgcaagg gccagggcgt
     7321 gggcggcatg ctcaagcggg cggtcaccgg cgaggggctg ccgctcatga ccgtgcgcgg
     7381 gcagggcgag gcctggttcg cgcacgaggc gcagaactgc ttcgtcgtgg gcatcgagcc
     7441 gggtgacgtg ttcaccgtca acggccgcaa tgtcctgtgc ttcgactcga cgctgacgta
     7501 cgagatcaag acggtgaagg gcgcggggat cagcggcggc gggctgttca acagtgtctt
     7561 caccgggcac ggcaagctgg ggctgatctg cgagggcaac cccctggtga tacccgtgtc
     7621 gcagcagcag cccgtgtacg tggacaccga cgcggtggtg ggctggaccg cccatctgca
     7681 cacctcgctg caccgttcgc agtccatcgg gtcgatgctg cgcggcggtt cgggcgaggc
     7741 ggtgcagctg aagctggagg gcgacgggta cgtcgtcgta cggcccagtg aggcgacgcc
     7801 gcagaaggtg cagcagcact gaccggccga ccggaagggg ccccgccgta cggcggggcc
     7861 cctggtgcgt cagcctccgg tggagcgtca gcgtccggtg gacggggtgt tggcggaggt
     7921 cacgttgacc ccggcccagg ccttgtcgac cgtctggtac tcgatgctgt cggcgccgta
     7981 catgtcggtg gcggccttca gcgtcgcgtt gcgcgcgtcg tggaagtccg tcgtggagac
     8041 catgtagcgg gtcagcgccc ggtagaagat cgcgagggcc ttggcccggc cgatgccggt
     8101 gaccgtcgag ccgtcggagg tgggcgagtt gtacttcacc ccgccgatcg tcttcctgcc
     8161 gcttccctcg gccagcaggt agaaggcgtg cgaggagaca ccggagccgg cgtggacctc
     8221 ggtgtcgtac gtctcgggcg accagtagtc gatggtcccc tcgagcttgt cgcgcgaggg
     8281 ctcgtcgaga cggcgcagga acttctggtc caggccgagc ttctcgccga cgaggtagtc
     8341 acccgcgtcc ttggagttgt tggtcgcgaa ctccatcccc gtgccgaaga tgtccgcgag
     8401 cgactcgttc agcgagcccg gctcaccgaa ctggttgccg tcccggtcca cgcgggtggg
     8461 ttcgagggcg gcggtggcgt cgacaacacc gtgggtcagc tcgtggccgg tgacgtccag
     8521 gacgaccagc ggcttcttga agaggtcgcc gtccccgtcc ccgtacagca tgcagccgca
     8581 ggcggagtcc cagaaagcgt tgccgacctt ggtgccgaag tgaaccatcg cgcgggcgcc
     8641 ggtgctgttg ttcttgatgc ccttgcgccc gaacgtcttc ttgtagaagt ccagggtctt
     8701 ggtgacgccg tactgggcgt cgaccgcggc gctctggcgg ctactggtct tgccggtgcc
     8761 ccacttgttg ttcttgtcgg tgaacttctt gccgcgcgag aaggcttcga ggtactgccc
     8821 cttggcgtcc cgggtctcgg tgccccagcg ggtggagtcc ttgaggagga agctcgtgcg
     8881 ggcggtctgg gtggtgctca gccccacctt gccgacgaag agggaggtac cggtgccgga
     8941 ggccttgcgc gggtagctcg cggccccgga gatgcccgtc agaagcgagg agccggtgag
     9001 cgcggagtcg gcggtgccgg tcgcggggtt cgccgtctcg ccccgctcgc gcagggtctg
     9061 ggccagcgag ggcgagatga actcgtcgct gtcgggggtg ttgctgcgga tgcggccggt
     9121 gacggcgtcg acgacgaccg tgcgggagcc ggtggcctcc gtggtcttgc tgtcggtcac
     9181 ccgcacctgg taggcgaggg cggagccgcc gtcccgcgcg tccacgacga gtgcggcctc
     9241 ggtggcgtcg ccctgggcgg ccgcggcggc cttctgctcg gcctgcgcgg gcgtcagctt
     9301 cgcctggccg gcggcggccg gcttgaccgt gtggtcggcg gcgcgggtca caccgaggta
     9361 cgtcgagcgc ttggtgaggt ggacgaccag gtcaccgccg aggaccggca ggccctggtg
     9421 ggtgcgcacg aaacggacgt gctgcttgcc gtccgggtcg gtcaggacgt ccttcgcctc
     9481 cagggtgtcc ccccgggaga cgccggtggc ggacgcgtgg gcgaacgctg ccgcccgggc
     9541 cgcgtccacc ggcgaggagg ccgcagccgc ggcgagggcg ggcgcgtcgg cgacagccgg
     9601 gaccgccggg agcgtggccg ccgtcgtcac ggcgatggcg atggccacgc cacgtatgtg
     9661 gggtctacgc actgatttcc ttcgaacatg ggcggccggg aacgccaacc acccgcacac
     9721 acagcgctgt tgggcgctgc gggggctggt cgggccccgg tgcaaaaccc tcaccgattc
     9781 accatgtaca tgtaaaggag aaagatccct tttactagct tcgaggtgat ctctttacaa
     9841 atgttcacct gtgagtgatg aaccggtgac caactgtgcg ttgcctgtac agatgtgcga
     9901 gaccacgaag aggttgcgtc ccgggccgcc cggaccagtg gatgtgaccg aagtcgcagc
     9961 gcctccggcc ccttacggcc ggaccggagg cgagccggcg tcagatcgtg cgccggctga
    10021 gggcggagag cagggtgcgc aggtcggcgg cgggacgcgg ggccggctgg acggaggcca
    10081 ggagtccgtg cgccacggtg agatgacggc gggcctcccg cagcgcggcc gagcgcccgc
    10141 ccgcctgttc cacaacggcc gccgcccgca ccaccgcggt gtcgtcgcgg gccgtgagga
    10201 gaccctcgag cgcggagccg gagggggtgg ccagcgcggc gagaaccgga aaggtcttct
    10261 tcccctgacg cagatcgccg tggacgggtt tgccggtgac cgcgggatca ccccagatgc
    10321 ccagcagatc gtcgacgatc tggaacgcca ctccgagatg acgtcccgtc cggtccagca
    10381 cggcggccgt ctcctccggc gcacccgcga ggtgggcgcc cagcgcgaga gcgcagccga
    10441 gcagcgatcc cgtcttgtgc tcggccatcg cctcgtactc ggcgacgctc accgcctcgg
    10501 gcccggtcca gggccggtgg gcgaacagca ggtcgtcggc ctgcccccgc accaggtcac
    10561 cgagggccgc gctcagccgg tgcgcggctc cgggcgcgga cgcggtggtc agcgtctgca
    10621 cggccagggc gaacagggcg tcgcccgcca ggacggcggg gcccgtgccg tacgccttcc
    10681 acagcgccgg gcggcctcgg cgcatcgcgt cgccgtccat gatgtcgtcg tgcaacagcg
    10741 agaaggtgtg cacgagttcg accgccacgg cggccggtac gccggcttcc gccggccctc
    10801 cggcggcctc cgcccccagc acggcgagcg cctgccgtac gcccttgccc tgactgtgcg
    10861 cggccggggc gccgcccgcc gcgccacggc ccagcgcgta gtcggccatc tcccgcatcc
    10921 atggatgcat cccgccgacg gcctcggcca gggccggggc gaccagttca cggcagcggt
    10981 gcaatatggc gggcgcttcg ggaccggcct tcagggccgt cgtcagggtg gtcatcggcc
    11041 ggcctcccga ccggccgacg accgcggcgc gagaccgagt tcctcgcgcg ccccacggat
    11101 gagctcccgg ccgtgccgca ggccgatgcc gtccagcacg ccgacgagtt cgtccagctc
    11161 ggcaccggtc tcggcacggt cgcggcccag gcgggccagg gacttgacca ggccgaggcg
    11221 ggccagggcc cggccgcgtg gctcgctcat cccgtcgaac tcggcgagcg cctgcgcgta
    11281 gacctcccgg gcctccgcgt aacgcccggc gcggtagagg acgttgccgc gcatcttgtg
    11341 gttgtaggcc agcgcgctga cgaggttcat ctcccggcag gagacctcgg cctcaccgag
    11401 cagggccagc gcgcgctcgg ggtcccggtc gcgcacggag acgatgtcgg cgagaccgcg
    11461 cagggcccag gcgtgaccgc ggcggtcctc ggcgcccgcg gcgatcgcgg ccgcctcctc
    11521 gaacatggcg tacgcggtgt cgtacgagcc ggtgttgcgg tgtatctggg cgatgccctc
    11581 cagggcccag acggtgtggc gcgcctcgcc gcgtttcctg gcctcggcga ggagctgctc
    11641 gtgcagggtg gtgacggcct cgtaatcgcc ctggatccga ccggtttccg ccattcccgc
    11701 gagcgaatag ccacgtacga cgacatcgcc cgcgtgcttg ccgagttcgg cggccagtcg
    11761 cagcagccgc caggccagag gcagggcgcc ccgctggcgg gccagggtgc cgccactcca
    11821 cagcgcccac gccatcgcgc cggtgtcgcc ggcctcgcgg gcggtgcggt agctcgcctt
    11881 ccaggcccgc tccgcgtccg cgacctggcc gagccggcgg tgcgcctcgg ccaccgccag
    11941 accggagcgg gccgcctcgc cccgcgcccc ggcgcgctcc gcggcgcgca gctgttcggt
    12001 gcccgcggcc aggacgtcgg tcagcgagga gttcaccgag agggtggtca gagcgccctg
    12061 gtactccggg gcgaaggcct tgccgtacat gagtgccttt cgatctgccg ccggccgggg
    12121 cgtatggcct cggccgtcgg gtgctggctg tcacggggtg ggcggcgccc tggcggacca
    12181 gctatgcact ccaggcatac acgtcacgta tacacaccat gtatacacag agcgtatagc
    12241 acaccggaca tccacccggg aaacctgggt ccatggatcc gccgggctgc tcgcccgtcg
    12301 ccgatcaaga cgtcagccgg gcccccaagg ttgcttcacg gcaaacgagt tggctcgcac
    12361 gcgcacatca ctcgtcacga ttagaacaga tcttcgaata tcgaggtacg ctgcacctat
    12421 gtccacgcac ctccagggat cgctcttcga ccagaccgac gaactcgggc tcggcccgct
    12481 ggacggcctg cgacggaccg tcctgggtgc cggggcctgg atcgatctgc tgccgggctg
    12541 gctcagcggc gccgacgccc tgttcgaacg gctcgccgcc gacgtgccgt ggcgggcgga
    12601 gcgacggaag atgtacgacc agacggtcga cgtgccccgg ctgctcgcgt actaccgggc
    12661 gggcgacacg ctgccgcacc ccgtcctcgc cgaggctcgc gacgcactgt ccgcgcacta
    12721 cgtggccgag ctcggcgaac cgttcaccac ggccgggctc tgctactacc gcgacggccg
    12781 cgacagcgtg gcctggcacg gcgaccggat cggccggggc gcccgcgagg acacgatggt
    12841 cgcgatcctc tccgtgggcg cgccccgcga tctggccctg cgtccgcgcg gcggcggcga
    12901 cgtcctgcgg cgcccgctcg gacacggcga cctgatcgtg atgggcggct cctgccagcg
    12961 gacgtgggaa cacgccatcc ccaagagcac ccgggcggcc gggccccgga tcagcatcca
    13021 gttccggccg agcggcgtga actgagcggc ctcggtgtca gggcgtgagg tgcatctgca
    13081 cggccggggc gtagcggtcg acgatgtcgt cgatggcggc ggcacgcaga tgggtgccgc
    13141 gggcgatgcc gaacatgaca ccgaggccga gcagcgcgct caccgcgagt tcggcacgca
    13201 gaccggcgtc ggggccggcc agtcgctcgg cgaggcggtc gccgacctgg gcgcggaagt
    13261 tggcgcgcag gatgtcgccc tgttcgccct ggaggggtgc gaagacgatg cgcaggacgg
    13321 ggtcggcgcc ccgctcggtc tggccgacca gcacatgccg gaccatgtgc cggccgaggt
    13381 cgtcgagggg cgcgtccagc aggtccggga catcggcctc gaaggacatc acgcgggcga
    13441 agagcgcgtc cttgttgccg aagtacttca gtatcagcgg cgggctgacc ccggcccggt
    13501 ccgcgaccgc cttgagggtg atgtccgcgt gggcgtggcg ggccagcaga tggcgggccg
    13561 cgcggaggat ggccgccttg gtcgcctcgg cgtcacggcg cgccggggcg gcggccggcg
    13621 gggtggcggc ggagggagtg gtcatggtgc tcatgctcct tccagcgcct cgtcgtggga
    13681 cggccgggta cggccgcggg cccgtcgcgt gccgtgggag tcggggtccc cggggatgac
    13741 gagggcggcg gcgcaggcca tcactgcgac cgtacccgcc atcgcgaacg ccagcagata
    13801 gccgtgcagg gtgggtaccg gggcgcctcc caccaggctg gtgtggtgga ccaggacggc
    13861 ggcgaccgcc gcgctgcaca cggcttggcc gatggtgcgc atcaggacgt tgacgccgtt
    13921 ggcggaggcg gtctgtccgg cgggcacggc acgcaggatc agggtgggca gggccgagta
    13981 ggcgagggtc gtgccgaccg cgatgaccgt ggcgcccacg atgatcatcc acaggtcgcg
    14041 gctgtccgcg atgcgcacgg cgtagccgac ggcgatgacc gcggccccga gtgccagcgt
    14101 cacgcgcggg ccgcgggcgg ccgagatgcg cgccgagacc ggcgagaaca gcagcatgat
    14161 gacgccgccg ggcagcaggc acagaccggt ctgcacgatg gacagcccga gtccgtagcc
    14221 ggtggccttg ggcgcctgca ccagctgcgc cgtgaccagc gagttgccgt agaaggcgaa
    14281 tccggtcagc agcgcggcca cgtgcggcag ggcgacccgg gggcgggagg ccagcttcag
    14341 gtccaccagg ggccgcgggg cccgccactg ctggaaccac cacagcgtca gtacgagtac
    14401 gcaggccacg agcaggccga cgatccgcgg actggtccag ccccactgcc cgccctgcga
    14461 cacaccgagg agcaggcaga ccaggcccgc ggccagcccc agcgcaccca gcgtgtcgaa
    14521 gcggcccggc tgccggacgg gcgactcgcg caccgcccac cacgccagtg ccagtccgcc
    14581 ggcgccgagc ccggtggtcg cccagaacat gacgtgccag tcggcgtact gcacgatcat
    14641 cgcggcgatc ggcagaccga gcgcggcgcc gatgcccacg gtggaactca tcagggccac
    14701 cgcggaaccc gtgcgctcgg gcgggagttc gtcgcgcagg atgctgatcg acagcggtac
    14761 gacggcggcc gccgcgccct ggagggcccg cgcggcgatg agcacgcgga tgtcggaggt
    14821 gacggcgcac agcagcgagc ccagggtcat cagcgcgagg gcggcgagca gaacccgccg
    14881 cttgccgtac atgtcgccgg cccggccgag caccggggtc agcaccgcgc cggagagcag
    14941 ggtggcggtg accatccagg agacggcgcc cgcggaagcg ccggtcaggc gcggcaggtc
    15001 gggcagcagc ggcaccacga ccgtctgcat gacggccatg aggattccgc cgaacgccag
    15061 gacggggacc gtcagccggt cgcggacacc cggccgtccg gccggtccgt cgggggtcgc
    15121 ggaccggtcg gacggggtgg atatcgggac catggtcact ccaggggcgg cagccgacgt
    15181 gaagaaggga ggtgaatagg aattcacctt agccgggtga atggtcattc acccagaatt
    15241 ctccgtcgga cgcggccgcc ggcggccggc ctaccggccc gtgcgcgcct ggacggtacg
    15301 cgccagtcgc ggccccagcc agcgcttgag cctgcgcagc gcctccagtt gtccggccgc
    15361 ccggtcgatc cggtagtaga gctgcggagg cacgtacggc agcagcgggg aatggcgctg
    15421 gccgagcagg gcgaacatct gcgggggcgg aaggcggatg tagcgcggga ggttctcgta
    15481 ccactgggcg ctgagccggg ccgcgctctg gatgtgcagg agcgcggact tgcgttcccg
    15541 ctcgtaggcg gcgagcgcgc ccggcaggtc gcggtgcgcg ctcagggctt cggcgagggc
    15601 gatggcgtcc tccagggcga gggtggtgcc cgcgccgatg gagtagtggg tggtgtgggc
    15661 ggcgtcgccg atcaggacga ggttgtcgcg atgccaggtg cggttggtga gggtgcggaa
    15721 gttcagccac tgggcggcac cgtcgctctg cgcccggccg atcagctcgt gcccgtcgag
    15781 gacgtcggcg aagagcttct ccagcagggc gagaccgtcg gcctcgctgg cccggtcgag
    15841 gccgagcccg gtccaggttt ccggggagca ctcgatgacg caggtgctgt ggccgtcgct
    15901 gaatccatag ccgtagcacc agatccagcc gtgttcgctc tccacaaagg cgaaggtgaa
    15961 cgagtcgaag accttggtgg tgccgagcca gatgtagcgg ttgcggccga gcacggtctc
    16021 gctgccgaag tggtcggcgt agcggccgcg cagcacgctg ttgaccccgt cgccggcgac
    16081 gaccagatcg gcctcgggca gtgggtcgtc ggcgccgatc tcatgctcgt actcgatgcg
    16141 gacgcccagg gaccgggccc ggtcggccag tacgtcgagg aatctgcggc ggccgatgcc
    16201 gaagccctcg tcgccgtggt ggaccgtggt gcggttccgg acgtgggcga ctccgtcgct
    16261 ccagcggacg gagttctcgc tgacggcgag cgccgactcg gggtcactcc cgcggagttt
    16321 gtcgagcagg ccgctccagt aggtcacgcc ccagccgtag gtcgatccgg cggggttccg
    16381 ctcgtggacg gtgatgtcgt gggacgggtc ctggcgcttc atcaggatcg agaagtacag
    16441 gcttgcgggt ccgccgccga cgcacgcgat cttcacgcgc actcccctat gttacgcaaa
    16501 gcggtcaatt gaccacgaag ggtagcagcg ccatcgtgca gaccgaccgt cccggcctct
    16561 tccgccgcgc ggcgggcggg ggcggtcgta cgatcgcggc ccgtcccgcc gcagacgaca
    16621 ggagcccctg tgacgcatcc gcccgccggc ccggtcctgg ccgcactcgt ctcccgggcg
    16681 accgggggcc gctactggcg actggaccgg ccgggcgccg gtctcgacgc cgaggcgatg
    16741 cacatcccgc cgggtgcggc ggccgagccg cccggtgacc gctcgcggga cgtcctcgtg
    16801 atcgccctcg acgggggcgg ccggctccgg acaccgggcg gatggctgga gttggcaccc
    16861 ccggccgccg tgtggctgcc ccccgccgct ggataccggc tgcacgcggg ggaggcgggg
    16921 ctgcactgcg tgaccgtacg cccgcgccgt ccggccgctc ccccggccct gccgacgacg
    16981 ggggcgaccg gagagcccgc atgcctgctg caccaggtct gcgccgagtg cggacgtatg
    17041 gccacggaga gcgacgcccg ctactgcaat cgctgcggga accccctgga gcggtgaggg
    17101 caggcgccag ttcgcgccag tctgcgcacg tgagccgcac cactcgcccc gcatcgacgg
    17161 caaaagatca ccgcgatggc gccgatccgg ggtggaactt ccccctccgc cgccgggtgg
    17221 gccacccggg gcggcaagat catcttcgtt caatcctgta tgacatgtag gtaattgtcc
    17281 ggatcgtagc caaccggttt tcgtcgattt ctccggctcc cgaccgggcg gataggcatg
    17341 ccgagtcgtc aacacacctc gactcagaag gacttcgcat gcccgaactc acccgccgtc
    17401 atgccctcgg ggccgccgcc gccctggcgg ccgtggccgg cactcaggcc cttgccgctc
    17461 cgtccgcgtc cgcggccggg caccacgggg gtccccagcc gttcgacgag gtctatcagg
    17521 ggcgccgaat agagggccgc gcgaccgggg gcggtcatca ccacggctcc gggtacggcg
    17581 tgttcatcga cgggatggaa ctgcacgtga tgcagaacgt cgacggcagc tggatcagcg
    17641 tcgtcagcca ctacgacccc gtggccaccc cgcgcgccgc cgcccgcgcc gcggtcgtgg
    17701 agcttcaggg cgcgccgctc gtccccttca actgaccgtc ccgcacgtag agttctggag
    17761 tcacccgcac atgaccgtac gcaagaacca ggcgaccctg acggccgacg agaagcggcg
    17821 cttcgtcgac gcgctcgtgg cgctcaagcg cagtggccgc tacgacgagt tcgtcacgac
    17881 ccacaacgcc ttcatcatgg gcgacaccga cagcggcgaa cgcacgggcc atcgttcgcc
    17941 ttccttcctg ccctggcacc gcagattttt gatcgagttc gagcaggcgc tccaggcggt
    18001 cgacccgtcg gtcgcgctgc cgtactggga ctggagcacc gaccgcacgg cgcgtgcctc
    18061 cctgtgggcg cccgacttcc tcggcggcag cggacgcagc ctggacggcc gggtgatgga
    18121 cgggccgttc gcggcgtcca ccggcaactg gccggtcaac gtgcgggtcg acagccgtac
    18181 gtatctgcgg cgcacgctcg gcggcggcgg gcgcgagctg ccgacccggg cggaggtcga
    18241 ctccgtgctc gcgatgtcca cgtacgacat ggccccgtgg aacagcgcgt cggacgggtt
    18301 ccgcaaccat ctcgagggct ggcgcggtgt gaacctgcac aaccgcgtcc acgtctgggt
    18361 cggcggccag atggccaccg gggtctcccc caacgacccg gtcttctggc tccaccacgc
    18421 ctacatcgac aggctctggg cccagtggca gagccgccac ccgggctccg gttatgtgcc
    18481 gacgggcggc acgccgaacg tcgtcgacct gaacgagacc atgaagccgt ggaacgacgt
    18541 acgccccgcg gacctgctgg accacaccgc gcactacacg ttcgacaccg tctgacggcc
    18601 gaggcgctcg aggtcccggc ggccactcgt gggaggccgc cggggtcgtg atccagggcc
    18661 ggcggatcag gcgggcggga aaagccgcac ggcctgtcag cccccgcgtc cttgggcatg
    18721 ctccgccggg gaggtcctag acgtcgtcgg cggtacggca ctccgggtgg ccccagccct
    18781 gcgcgttctt ggcgatgggc tcgcccgccg cgtaggggcg gccgcagaca cagcggccgg
    18841 ggaacttcgc cttgatcgtg cgcgtgctcg tcttggcggt gcgcgcggag gcacgcttct
    18901 tggcgggagc gccgcgaccc gcggagccgg ccgcgacggt gtcgggcgac ttcggcggct
    18961 ccggggagcc gtactcgctg cccgccggtt cctggacgat cgccgcctgg ctggcggcac
    19021 ggtcggcgaa gtcgttgagc cggtcgccgt cgacctggtg cgcggggacg taacggaact
    19081 cgacggagcg tccgtcgagc agttcgtcga tgcgggcgac cagttcctgg ttggcgaccg
    19141 gcttccccgc ggccgtcttc cagcccttgc gcttccagcc gggcagccag gtcgtgacgg
    19201 ccttcatcgc gtactgggag tccatccgga tctccagcgg gacgtccgga tccatcgcgc
    19261 tcaacaagcg ctccagcgcg gtgagttcgg ccacgttgtt cgtggccgtg ccgagcgccc
    19321 cggccgccca gcgggtcggg gtctcctcgc cgtcggcgac gacccaggcc catccggccg
    19381 gtccggggtt tcccttcgac gccccgtcac aggcggccac cacacgttca gacatgcccc
    19441 cgatcatgcc acgctccgcc gggcgctccg ggcccgggtc cgacgccgcc gacgccctcc
    19501 aggaggggct ggcccccagc acgatcaccg tgcgtcggga cgtggacgaa ggtcgcgccg
    19561 cacggggtgg tccacctgga ggggcggagg tttcggccag accttgcctg gttcgacggt
    19621 gttcacgcac gctacgggga cctagcgtca cgatcatgaa accgttgacc ggcagcacca
    19681 ccgaccaggc accggccgat ccggccgcca ccgacgacgt gttggccacc cagcccatcg
    19741 gctactggag cggtctggcc cacacggcgg tcacccggca gctgcgggac gccatggcca
    19801 ggatcgacgt cacacagccg cagtactggg tgctcaaccg cgtgcacggc gggcccgcgg
    19861 cgccgggccg ggaggaggtg gtcacccagc tgacgcccct cgcggacggg ccgcacgaga
    19921 tcgcgcgggt cgtcgaccag ctgcttcacc ggggctggct tcggatcgac gccggacagc
    19981 gcctgcgtct caccgacacc ggggaggctg ccaggaagcg gctgcgtgag ctggtgaccg
    20041 agctgcgcgc ggtggtccac gagggcatca gcgacgagga gtacgtgacc gcgctcaagg
    20101 tgctgcgcac gatgatcgcc aacgtcgagg gcgatgcggg ctgctaggcc agggcggcgg
    20161 agggacgcgg gcgctgcccc ggccgcagga cggccgggcc ttcgtgtcgt ggtcctggcg
    20221 ctgccgtcag gacacgtcgg tcagcttggg cagctcgccc tgggtggtct tgatgtcgat
    20281 gacggcgaag gacgcgccct gcgggtcgct cagcgccgcg aaacggccga acgggctgtc
    20341 catcggtccg aaccgcagga tgccaccgtg ctcggtcgcc ttcgcgacgg ccgcgtcgac
    20401 gtcctcgacc gtgaagtaga cgttgatgaa ggacggaacc tcgggcggga agtcgtccgt
    20461 catcttcatc cggccgagga ccgcgtcctc gccgacgctg aagatcctga agtcgaccgc
    20521 ctcgtcctcg atctgctggg cggtgagcgg gaagacggcc gggaagaacg cgtcgggctt
    20581 ctcgggctca cgggtgaaga cctcggccca gcagtacgcg cccggcacgg ccgtcgcctc
    20641 gaagcccttg tggacgccgg gctgccagac gccgaagacg gcaccgctcg gctcacgggc
    20701 cagggccatg gtgccgaaat cgccgacctg catcggctcc atcagcacct cacccccgtt
    20761 gtcccggatc tttcgggcgg tcgcggcggc gtcgggagac gcgaagtaca ggcaccaggc
    20821 ggagtgcccc tcctgtccgg gcatgggcgg tacgacggcg gcgaccgcct tcccgtcggc
    20881 gtacgcctgt gtgtagttgc cgtactcgga cgacgactcg ccgaacgtcc agccgagcac
    20941 atcgccgtag aaggtcttgg ccccctcgac atcgctgaac atcgcgtcgg cccaacaggg
    21001 ctttccctcg gggtatacgg ccatgatccg tgcccttccg tggcgtctcc ggttcgacgt
    21061 gcgggtgcgg ttcctcacgc tagccaggca tcggccgggc cgcgcgccga acggcccgag
    21121 ccggaccaca ctgggacggg gcgatcgtcg acgggacggg gtacgggcga tgtgggcatg
    21181 ggaagtggag cggccgggtc cgatcgagga cggtccgctg cggttcgtgg agcggccggt
    21241 cccggtaccg ggacccggtg agctgctcgt gcgggtgcgc gcctgcgggg tgtgccgtac
    21301 cgacctgcac gtcagcgagg gcgacctgcc ggtgcaccgg ccccgggtga cacccgggca
    21361 cgaggtcgtg ggcgtggtgg cgggacgggg cgcggacgcc ggcggctacg cggtcgggga
    21421 ccgggtgggg gtggcctggc tgcgccgtac ggacggcacc tgccggtact gcgtgcgcgg
    21481 ggccgagaac ctctgtccgg cgtccgagta caccggatgg gacacggacg gcggctacgc
    21541 cgagtacacg accgtcccgg ccgcgttcgc gtaccggctg cccaccgacg tcgacgacgt
    21601 ggcgctggcg ccgctgctgt gcgcgggcat catcggctac cgggcgctgg tgcgggcgtc
    21661 gctgccaccg ggcgggcgac tcggtctgta cgggttcggc ggcagtgccc acctgtgcgc
    21721 acaggtcgcg ctcgcacagg gcgccaccgt gcacgtactg acccgggacc cggcctcgca
    21781 gcggctcgcg ctcgccctcg gggccgcctc ggcgggcggg gcgtacgaca ccccgccgga
    21841 gccgctggac agcgcgatcc tgttcgcgcc ggccggcggt ctggtgccgg tcgcgctgcg
    21901 ggccctggac cgcggcgggg tgctgtcggt cgccggcatc catctgagcg acaccccgcc
    21961 gctgtgctac gaacgcgagc tgttctacga gaaggagctg cgcagcgtca cctcgaacac
    22021 gcgcgcggac ggccgggagt tcctggagct ggcggcccgg tacggggtcc gggccacgac
    22081 gcacacctat cccttgtccg aggcgcagca ggccctgcgg gatctgaagg cgggccgctt
    22141 cgacggggcg gccgtcctgg tcaacgacgt ctgaacggca ccgggccgcg caggtgcggc
    22201 tccggcctgc gcgtgcgtgg atggatccag gcgtgtggtg gcggaggtgg cccgcgatgg
    22261 acgacgtgga cagtgcgaac gcgccgtccg gcgcgttcga cgccgtcgaa gcgatcggca
    22321 ccaccctcga cgagcgcacc acgtgcgcgg aactcgccac gtacgtgtgc cggaagacgg
    22381 gcgaggccgc cgcggtggac ctgctgcccg tcgacgttcc ggccgcgccg cccatgccgc
    22441 acgcgccgca gccggccctg acccgggtgg ccaccgcggg ccggagcggg ctgctggcgt
    22501 cgtggggcgt cgagggcccg cggccgctgg ccgtgcgggc gctggacgag gggcatccga
    22561 tcaccgcctc gatggatctg tccggccgtg tcccccggca ggtgatgacg gtgccgctgc
    22621 tggcccacgg ccgtctctac ggggtgctgc tcgtggtccg gcagggtccg gcgttcacgg
    22681 accgggacac ggcggtcacg cacttcgcgg cccgcctcgc cgccgtccac ctggg
//
