LOCUS       NC_003155              25311 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1277517
            Orig. end                         :: 1302828
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25311
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25311
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25311
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15311]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15311
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            931..2337
                     /db_xref="GeneID:41538119"
                     /locus_tag="SAVERM_RS05545"
                     /old_locus_tag="SAV_1010"
                     /old_locus_tag="SAVERM_1010"
     CDS             931..2337
                     /codon_start=1
                     /db_xref="GeneID:41538119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992310.1"
                     /locus_tag="SAVERM_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1010"
                     /old_locus_tag="SAVERM_1010"
                     /product="hypothetical protein"
                     /protein_id="WP_010982448.1"
                     /transl_table=11
                     /translation="MSGPMALEPGGTEQDTLALRLAEDRPLAPRPPDDHTVALRLPGRG
                     TDSDAVDRLAAELADRIGPAVHSYEVAALLESEGLTAETIQERYGHANLFALASTLYAR
                     VPRTYPEPPRPADPWRPDHVRCALRGALFALPGLAYLLTGRLWHAERDTSVLIVAGLVS
                     WAWGQALGHRAYLRMTTGRREAGRTLLKGAPLGAAAATLAGAVFAGAGTVALIAAAQSV
                     YLSAAGVLLVLGRERLLLAALTPVIAGAVVLPWWEPGPVLRAGLPLLALLAATAAAGWS
                     LRVTLAASPAPGATRPGLLRSLPYGLFGLAAGVLVLLEGRRHPYAVIVLTLSMGPAEWL
                     LYRYRGMSVAALRATATPAAFLLRSAGVLGFCLLAYLLPLLPAALLTGAEPAPLLLLAA
                     TLWTALLLQAFGVAWPPAGVCLAAAGGAGAITLFHLPPGAAALSLCCGAAALCLTACAL
                     RLLGRPAAHA"
     gene            2490..3499
                     /db_xref="GeneID:41538120"
                     /locus_tag="SAVERM_RS05550"
                     /old_locus_tag="SAV_1011"
                     /old_locus_tag="SAVERM_1011"
                     /pseudo=""
     CDS             2490..3499
                     /NRPS_PKS="Domain: NAD_binding_4 (8-183). E-value: 3.9e-20.
                     Score: 64.0. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS05550_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GeneID:41538120"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468244.1"
                     /locus_tag="SAVERM_RS05550"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAV_1011"
                     /old_locus_tag="SAVERM_1011"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.5e-13, bitscore:
                     47.1, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 5.1e-18, bitscore:
                     64.0, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.4e-16,
                     bitscore: 59.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAPLAAVTGAEGFIGSHLTEALVASGHRVRAMAQYNSFSSYGW
                     LETLPADVLDHVEIVLGDVRDPGSVRGLVEGADCVYHLAALIAIPYSYQAPHSYVDTNV
                     TGTLNVLEAVRALGTPRLVHTSTSETYGTAQTVPITEDHPINTQSPYAASKAGGDRLAD
                     SYHASFDTPVVTLRPFNTFGPRQSMRAVIPSVIGQVAAGARTLTLGDLRPTRDFTYVKD
                     TAQAFLAVGTAPAAQVVGRTFNAGTGGEISVGDLVGGLIGQG"
     aSDomain        2514..3038
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS05550_NAD_binding_4.1"
                     /evalue="3.90E-20"
                     /label="SAVERM_RS05550_NAD_binding_4.1"
                     /locus_tag="SAVERM_RS05550"
                     /protein_end="183"
                     /protein_start="8"
                     /score="64.0"
                     /tool="antismash"
                     /translation="VTGAEGFIGSHLTEALVASGHRVRAMAQYNSFSSYGWLETLPADV
                     LDHVEIVLGDVRDPGSVRGLVEGADCVYHLAALIAIPYSYQAPHSYVDTNVTGTLNVLE
                     AVRALGTPRLVHTSTSETYGTAQTVPITEDHPINTQSPYAASKAGGDRLADSYHASFDT
                     PVVTLRPFNTFG"
     gene            3532..4245
                     /db_xref="GeneID:41538121"
                     /locus_tag="SAVERM_RS05555"
                     /old_locus_tag="SAV_1013"
                     /old_locus_tag="SAVERM_1013"
     CDS             3532..4245
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538121"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655558.1"
                     /locus_tag="SAVERM_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1013"
                     /old_locus_tag="SAVERM_1013"
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="WP_010982451.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.1e-11, bitscore:
                     41.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAVILAGGKGVRLRPYTTALPKPLVPIGDQHAILEIVLRQLAAA
                     GFTGCTIAIGHLGEIIRAYVGDGSQWGMAVDYATEESPLGTMGPLLTMRERLPESFLVM
                     NGDILTDLDYADVLRQHRDSGAPLTIATYARKVHIDFGVLTTQAGRVVGFTEKPSMDYR
                     VSMGVYGLSRKTLDGYTPGLPLGFDELVLDLLKTPNLPHAYDFDGYWLDIGRPDDYDRA
                     NAEFTTRKSLLLKGA"
     gene            4253..5179
                     /db_xref="GeneID:41538122"
                     /locus_tag="SAVERM_RS05560"
                     /old_locus_tag="SAV_1014"
                     /old_locus_tag="SAVERM_1014"
     CDS             4253..5179
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538122"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827714.1"
                     /locus_tag="SAVERM_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1014"
                     /old_locus_tag="SAVERM_1014"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_010982452.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.1e-16, bitscore:
                     58.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVLGFTGYLGRHVVERLRALPGTRVLGGGRSAGAEFGIDLAT
                     ARPDTLAKALASAAPDAVINCAGATGGDAVTLAEVNSRGPAVLCAALREAAPSARLVHL
                     GSAAEYGPGTRGIRVTESAATRPLTPYGATKLAGTITITTSGLDAVVLRVGNPVGPGAP
                     LTGLPGRVAGLLLASGGDPDAVIRLGDLSAHRDFVDVRDVARAAVLAATAPAPLPRVLN
                     IGSGSAVPVRDLVAALTHVAGFPGRVEEKGGGSARSAEVSWQCSDIGAAGDTLGWRPSY
                     TLDASLAALWAAVREGPSPRLDGGRAP"
     gene            5176..5838
                     /db_xref="GeneID:41538123"
                     /locus_tag="SAVERM_RS05565"
                     /old_locus_tag="SAV_1015"
                     /old_locus_tag="SAVERM_1015"
     CDS             5176..5838
                     /codon_start=1
                     /db_xref="GeneID:41538123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827713.1"
                     /locus_tag="SAVERM_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1015"
                     /old_locus_tag="SAVERM_1015"
                     /product="spherulation-specific family 4 protein"
                     /protein_id="WP_010982453.1"
                     /transl_table=11
                     /translation="MSLLIPLYVHPAEDPGAWHRLITAADRTYAVVLNPANGPGTSPDP
                     AFAAAAGALRAAGARLLGYVDTNYGARTAAEVADDVVRHREWYAADGCFLDRVTSAPAE
                     LPLCKRLVQTVRRLGASPVVLNPGVHPAPGYARLADLVVTFEGHWSTYVSAFSRPAWTL
                     RHPPERFCHLVYGVPEALVPLAVRTARERGAAVCGPVTGEIPNPWTRLTPALGETEQ"
     gene            complement(5926..6384)
                     /db_xref="GeneID:41538124"
                     /locus_tag="SAVERM_RS05570"
                     /old_locus_tag="SAV_1016"
                     /old_locus_tag="SAVERM_1016"
     CDS             complement(5926..6384)
                     /codon_start=1
                     /db_xref="GeneID:41538124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010473752.1"
                     /locus_tag="SAVERM_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1016"
                     /old_locus_tag="SAVERM_1016"
                     /product="hypothetical protein"
                     /protein_id="WP_010982454.1"
                     /transl_table=11
                     /translation="MNSDHDGPDRDHQRPAGVSDETVEALGALSKALETTERARGHLYS
                     FHQLTGGADLELGHAVELLRRAGHHRSADRVEKEILGRNVIPGHWTFQIIESYNDTYYE
                     PFKALERSVLNELAEGRDHLYEAEMKEARRTHGHRDHTARPDSPGTPT"
     misc_feature    complement(6514..6529)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            6543..6911
                     /db_xref="GeneID:41538125"
                     /locus_tag="SAVERM_RS05575"
                     /old_locus_tag="SAV_1017"
                     /old_locus_tag="SAVERM_1017"
     CDS             6543..6911
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670590.1"
                     /locus_tag="SAVERM_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1017"
                     /old_locus_tag="SAVERM_1017"
                     /product="low affinity iron permease family protein"
                     /protein_id="WP_037650287.1"
                     /transl_table=11
                     /translation="MTVPHPAERSRHGRGWFEKLAEAASNLTSSPVFYCFCLLLVFAFI
                     VAHAVGLELTWQLLIGDIMTAVNLLLLALLKNSERRAEHAIQHKLDSIAAALLEQREGH
                     SRQAHEELRKAIGIEDEF"
     gene            complement(6967..7515)
                     /db_xref="GeneID:41538126"
                     /locus_tag="SAVERM_RS05580"
                     /old_locus_tag="SAV_1018"
                     /old_locus_tag="SAVERM_1018"
     CDS             complement(6967..7515)
                     /codon_start=1
                     /db_xref="GeneID:41538126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005473530.1"
                     /locus_tag="SAVERM_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1018"
                     /old_locus_tag="SAVERM_1018"
                     /product="DUF6328 family protein"
                     /protein_id="WP_010982456.1"
                     /transl_table=11
                     /translation="MSLIERRQRSSDEARTSQEGRASDSGTRADEGESEQERVNRRWQE
                     ILQETRVAQTGVQILFGFLLSVAFTPLFRELGTFDRGVYVAAVLLGAAATGALIAPVSI
                     HRFLSGQRMKDELVAAAGRLMMGGIVLLALTIGCTVLLILHAVLPSSLAEILAGAVMLW
                     FAFCWYLLPWILRSRADKG"
     gene            complement(7670..9229)
                     /db_xref="GeneID:41538127"
                     /locus_tag="SAVERM_RS05585"
                     /old_locus_tag="SAV_1019"
                     /old_locus_tag="SAVERM_1019"
     CDS             complement(7670..9229)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538127"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606406.1"
                     /locus_tag="SAVERM_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1019"
                     /old_locus_tag="SAVERM_1019"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_078936690.1"
                     /sec_met_domain="DAO (E-value: 5.7e-12, bitscore: 44.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSRRPAAARRGRDRRARMLPPRPGATRFNGARPPTTAVVGGGI
                     AGLAAATALAERGVRVTLYERQPDLGGRLSGRPVGLRDGSTVTMSRGFHAFFRQYYNLR
                     GLLRRTDPRLERLTALPDYPLRHSAGLHDSFRRVPRTPPWSALGFVALSPTFGLRDLIR
                     MNPVAALPLLDVSVPDVYTRLDAVSAHDFLRSIRFPEAAHHLAFEVFSRSFFADPRELS
                     AAEMALMFHIYFLGSSEGLLFDVPDEPFPTALWDPLAGYLLRHRVEVRTSTSVESVAPT
                     RDGGFAVATPEETGRHDTVVLALDAGGLRSLAGRSPTLADAPWRERMARLRNAPPFLVS
                     RLWLDRPVARDRPGFLGTSGYGTLDNVSVLERWEGEAARWSARTGGSVVELHAYALPED
                     AVREVEQKRMLEQLCRVYPETRAATVVDERHEWRADCPLFPVGGYHDRPTVRTPEPGLV
                     VAGDLVRTGLPVALMERAATSGFLAANALLERWGVRGQTLWTVPDGGRSAVLRRVARWG
                     SA"
     gene            complement(9226..9957)
                     /db_xref="GeneID:41538128"
                     /locus_tag="SAVERM_RS05590"
                     /old_locus_tag="SAV_1020"
                     /old_locus_tag="SAVERM_1020"
     CDS             complement(9226..9957)
                     /codon_start=1
                     /db_xref="GeneID:41538128"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677064.1"
                     /locus_tag="SAVERM_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1020"
                     /old_locus_tag="SAVERM_1020"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_010982458.1"
                     /transl_table=11
                     /translation="MTLLRDADLAAAFDRAARSYDTLVAANPGYHAHLRRSARRLGLPH
                     GGSGTRVLDLGCGTGASTAALAAVLPGAEITAVDASAGMLERAAAKPWPDRVTFVHAPA
                     ERLTEAGVEGPFDAVFAAYLFRNAAAPDSVLTAVHDVLAPQGRLAVHDYTLSGRARDRT
                     VWTVVCGGIVLPVATALGDGRLYRHLWRSVVEFDTADEFAGRVRAAGFDCVRVLPLPGW
                     QTGITHTVVGRRAGTDTATGR"
     gene            complement(10001..11194)
                     /db_xref="GeneID:41538129"
                     /locus_tag="SAVERM_RS05595"
                     /old_locus_tag="SAV_1021"
                     /old_locus_tag="SAVERM_1021"
     CDS             complement(10001..11194)
                     /codon_start=1
                     /db_xref="GeneID:41538129"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134614.1"
                     /locus_tag="SAVERM_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1021"
                     /old_locus_tag="SAVERM_1021"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_010982459.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1.1e-111,
                     bitscore: 372.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEADVAIVGAGAAGLSLAHRLACPVRGAPRISVVLLEAPPGPLR
                     PPRRTWCFWERGPGRYDAAVTASWQRLRVRAPGGRPIEGDITPLRYKMIRSDDFEALMA
                     HDLALSGGVQRVEATVEAVEGVPGGAEVYAYTAAGRPLPVRARWVFDSRPLGSLPAART
                     TLLQHFHGWFVRSDLPVFDPGTVELMDFRTPQPPRGLSFGYVLPTGRRQALVEYTEFSP
                     AVLPRSAYEAALRHYTRDILHLPGLEIVSTETGVIPMTDAPFARQTAASVFRIGAAGGA
                     TRPSTGYTFAAVQRQTRAVAAALCRGRRPLPPPAHSARSRAMDAVLLRALDSGRIGGAA
                     FFARLFSRVPMERLLRFLDGCTHLHEDLSIGVHTPVLPMLRSAAELPYLPRRPFPGP"
     gene            11507..12748
                     /db_xref="GeneID:41538130"
                     /locus_tag="SAVERM_RS05600"
                     /old_locus_tag="SAV_1022"
                     /old_locus_tag="SAVERM_1022"
     CDS             11507..12748
                     /codon_start=1
                     /db_xref="GeneID:41538130"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007496680.1"
                     /locus_tag="SAVERM_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1022"
                     /old_locus_tag="SAVERM_1022"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_010982460.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-55, bitscore:
                     187.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRSKATDHQAAGPSPGPRDAFRPASVDEDVPAAVGRLLDRFLAE
                     RVARAAALDPVFAHDIAERVARFTLDGGKRTRSQFVWWAHRACGGPAAGAEAALRVGAA
                     LELIQTCALVHDDVMDGSRLRRGRPALHTDVSAQYADAVLPAPGTRFGEAAAILAGDLA
                     LAWADDVVADTDLAPDPGRRVREVWSCLRMEMVAGQYLDIQGQATSSHSEARAMRAACL
                     KSALYSVQRPLELGAALAGADTATTQALCSAGRCVGLAFQLRDDLHDVFEEPRRTGKPS
                     GGDIRAGKPTYLVAVARARAEAAGDRGALAVLRRSLGCADLSDADLARVRDVLVTTGAR
                     DTVEAEIDRLVAQGLRHMGAASLAPEGRRHLDALLRSAAGAPSVRRQAPDASRSENGMP
                     VSLLLTATAEGASR"
     gene            12745..14286
                     /db_xref="GeneID:41538131"
                     /locus_tag="SAVERM_RS05605"
                     /old_locus_tag="SAV_1023"
                     /old_locus_tag="SAVERM_1023"
     CDS             12745..14286
                     /codon_start=1
                     /db_xref="GeneID:41538131"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992099.1"
                     /locus_tag="SAVERM_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1023"
                     /old_locus_tag="SAVERM_1023"
                     /product="phytoene desaturase"
                     /protein_id="WP_010982461.1"
                     /sec_met_domain="DAO (E-value: 2.8e-18, bitscore: 65.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRTLRGRTDHVVVVGAGLAGLSAALHLLGAGRRVTVVERDLLPG
                     GRAGRLVRGGYLIDTGPTVLTMPDLADEAFAAVGDSLRDRVDLIPLHPAYRARFADGST
                     LDVHTGAEAMEAEIERFAGAREAAGYRQLRDWLERLYRAQMRRFIDSNFDSPLQLLTPD
                     LARLAALGGFGRLDARIGRHLRDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAG
                     VYFPRGGMHALPRAMADAAAQAGAELRFGQDVTRLERAGDRITAVVTAYDRIPCDAVVL
                     TPDLPVTYRLLGRAPRRPLRIRNSPSAVVLHAGTDRTWPGLAHHTLSFGAAWGRTFDEL
                     TRTGGLMSDPSLLITRPTATDPGLAPPGRHLHYILAPCPNTDIGPSAAAWGDLAPRYRD
                     SLLTELEARGLDGIGSAVEEECLVTPADWAAQGHAAGTPFSAAHTFAQTGPFRPRNLVR
                     GTANAVLAGCGTTPGVGVPTVLLSGKLAAARVTGGTRRTPRRMPASRTASGRTLS"
     gene            14283..15311
                     /db_xref="GeneID:41538132"
                     /locus_tag="SAVERM_RS05610"
                     /old_locus_tag="SAV_1024"
                     /old_locus_tag="SAVERM_1024"
     CDS             14283..15311
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538132"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144573.1"
                     /locus_tag="SAVERM_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1024"
                     /old_locus_tag="SAVERM_1024"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_010982462.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.1e-117,
                     bitscore: 390.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.5e-62,
                     bitscore: 210.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRELDAAGITDPSLRKAYTHCRRLNARHGKTYFLATRLLPVER
                     RPAVHALYGFARWADDIVDSLDTTVGPAVRSAALGRLQESLRTGLREGHSTEPVVLALA
                     ETARRYAIDHQHFSDFMTAMRSDLEVTGYETYADLRGYMHGSAAVIGLQMLPVLGTVVP
                     REEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLRAHGVDRDLLRWSRDTGRR
                     DRRITRALKAVEGLTRGVYREAAPGLAMLDPVARPCIRTAFVLYGGILDAIADDGYAVV
                     HRRAVVPRRRRAAVALDGLVRLGVARLGSRADARLPTLPDPWRLPALVPRSSPRPAHEE
                     VA"
     gene            15308..16387
                     /db_xref="GeneID:41538133"
                     /locus_tag="SAVERM_RS05615"
                     /old_locus_tag="SAV_1025"
                     /old_locus_tag="SAVERM_1025"
     CDS             15308..16387
                     /codon_start=1
                     /db_xref="GeneID:41538133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144574.1"
                     /locus_tag="SAVERM_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1025"
                     /old_locus_tag="SAVERM_1025"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_010982463.1"
                     /transl_table=11
                     /translation="MTPDRTDRPARRRRYPLSLRRHPIRWEDQRPTWRDARPAVIAEAL
                     KRAQARPSGNWYVVGATRDVREDRPLARTVAGLEVVVWRDGEGRLVAGPGVCPHLGAPL
                     RDSPVRCGTLMCRWHGLALSGTPFAGWEPLPVHDDGVLVWVRLDEVGGERPLEAPVVPA
                     RPALSGAVSAVYVGVGICEPEDVVANRLDPWHGAWFHPYSFVDLTVVTPGETVAPEEGE
                     TEGVETGGDEAEGAETEDGFTVDVSFKIAGRLVVPVRAVFTAPEPRTVVMRIAEGEGRG
                     SVVETHATPLGPDDRGRPRTAVVEAVLASSDRRGFAVARAMAPVLRPLMRAAAGRLWRD
                     DLAYAERRRHLRSTGRFPG"
     gene            complement(16608..18689)
                     /db_xref="GeneID:41538134"
                     /locus_tag="SAVERM_RS05620"
                     /old_locus_tag="SAV_1026"
                     /old_locus_tag="SAVERM_1026"
     CDS             complement(16608..18689)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006373955.1"
                     /locus_tag="SAVERM_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1026"
                     /old_locus_tag="SAVERM_1026"
                     /product="glycoside hydrolase"
                     /protein_id="WP_037650281.1"
                     /transl_table=11
                     /translation="MARRTRTRRLLGTIGVTALATGAALVTAPPTNAQTPAAAATAAVT
                     VQPDPSYRADRFEGWGTSLVWFANATGDYPAEIREKLAELLFDDDGLALNIARYNIGGG
                     NAPDVKDYLRAGGAVEGWWNAPAGTTREDTDWWSADDAADWNPNADATQRWWVDRIKND
                     IDHWETFSNSPPWFMTASGYVSGGFNSSEDQLKADSVDDFAAYLAGATKRLEKAHGIKV
                     DTLDPFNEPNTGYWGTRLGSDGRPVGGRQEGAHIGPELQQKVIRALAPALKKAKTGTKI
                     SAMDETNPNLFAQNWNSYPQDVRDLVGQMNVHTYGTGGRTSVRDLAKAADKPLWMSEVE
                     GDWGDGQSFTDMRPGLGLAQQMVDDLRELEPKAWVFWQPVEDYDNMKPGGESAKGGNWG
                     SIQLPFSCTSADTLATCPVHTNTKFDTARNFTHYIKPGDRLIRTDDTSSAAAVSTKGNA
                     ATVVHVNKTTSARTVTIDLSKFGHITRDATVTPVVTSAAGKLERQAPVEVTGSRAAVTV
                     PAQSVTSFLVKGVSGVAKDAALLCKGHTYQLTGVQSGKALTVADDGTQLVIRTAGTDAA
                     GTGQQWQVRQISGDTGNRQRYVFTNPAAGKRLAVRDGAPVLEADRGHRDKATQWIMSTT
                     GDGTWTLVNAATGRLLEVGGQATTDGAAVTTWTPNSGSNQRWSVTDVTDQNGSRSSGL"
     gene            complement(18790..20832)
                     /db_xref="GeneID:41538135"
                     /locus_tag="SAVERM_RS05625"
                     /old_locus_tag="SAV_1027"
                     /old_locus_tag="SAVERM_1027"
     CDS             complement(18790..20832)
                     /codon_start=1
                     /db_xref="GeneID:41538135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971736.1"
                     /locus_tag="SAVERM_RS05625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1027"
                     /old_locus_tag="SAVERM_1027"
                     /product="beta-galactosidase"
                     /protein_id="WP_010982465.1"
                     /transl_table=11
                     /translation="MISTLLSQLNGPDGDRTPRLAYGADYNPEQWPREVWEEDIRLMRE
                     AGVNIVSVGIFSWARIQPAQGQWDFAWLDDVMDLLHAGGIGVDLATATASPPPWLATAH
                     PEILPVTASGETVWPGARQHWRPTSPVFRTHALRLVRKLAERYADHPALVAWHVSNELG
                     CHNIYDYSDDAARAFRDWLRARYTTLDALNHAWGTAFWSQYYSDWDQILPPRLAASHPN
                     PTQQLDFKRFSSDALKAYLRAERDLLREITPEVPVTTNFMVMGRTKGMNYADWAQEIDF
                     VSNDHYVSPGPQDRDELSFSANLVSGIAGGRPWFLMEHSTSAVNWQPVNLAKRPGDLAR
                     DSLLHVAHGADAVCFFQWRQSAAGAEKYHSAMVPHAGPDSEVFRAVTALGGTLRTLAPV
                     AGTEREPARVGIVFDWESWWASEQDSHPTSLLDYRREALDWYSALLALGIRADVVTPQA
                     DLDRYQLLITPVLHVVPAALAKELTRYAENGGHLVTTYFSGVVDENDHIWLGGYPGALR
                     DLLGIRVEEFGPLLDGDTVALDDAATGTLWTDRITVTDPEVEVLARYRTGTYAGHPAVT
                     RRAVGRGSAAYVSTRLGPDGLTALLPKLLGPAAVGSELPDGVGGDVELIVRRGAGSRYL
                     FLVNRTDGTVPLTGLAGELLIGRAEDDGTVVLSPRDVAVLRQPTR"
     gene            complement(20884..22221)
                     /db_xref="GeneID:41538136"
                     /locus_tag="SAVERM_RS05630"
                     /old_locus_tag="SAV_1028"
                     /old_locus_tag="SAVERM_1028"
     CDS             complement(20884..22221)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538136"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527319.1"
                     /locus_tag="SAVERM_RS05630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1028"
                     /old_locus_tag="SAVERM_1028"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_010982466.1"
                     /transl_table=11
                     /translation="MRRTTRRLMRGLAVLSVLALGATACGGSDDDSADQKPVSAGDIQA
                     ALKKGGTVTVWAWEPTLKTVAADFEKKYPKVKINLVGERSGDKHYTALSNAISAEKGVP
                     DIAQVEYFALGQYALTKGLTDLTPFGADKLKAKYTPGPWNAVSEGDKVYGLPMDSGPMA
                     LFYNKKVFDKYKVAVPTTWDEYVEAARKLHKADPKVYIAADAGDAGLTTSMLWQAGSRP
                     YQVDGTKVKIDFADAGAKKYTDTWQKLIDEKLVAPIYGWTDDWYKGLGDGTIATLPSGA
                     WMPANFVTGVPKASGDWRAAPLPAWTKGDKASAENGGSSLTVPELAKNKELAYAFVEYA
                     NAGDGVQTRIKQGAFPATTAELQSTEFQNTKFDYFGGQEANKIFADSAANVADDWSYLP
                     FQQYANSIFNDTVGKAYISKTKLADALKSWQDASVKYGKEQGFTVE"
     gene            complement(22313..23269)
                     /db_xref="GeneID:41538137"
                     /locus_tag="SAVERM_RS05635"
                     /old_locus_tag="SAV_1029"
                     /old_locus_tag="SAVERM_1029"
     CDS             complement(22313..23269)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538137"
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324160.1"
                     /locus_tag="SAVERM_RS05635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1029"
                     /old_locus_tag="SAVERM_1029"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_010982467.1"
                     /transl_table=11
                     /translation="MSSTSSPVTTDSQPASVPATGPTKGAPRLRTPRKHVPGRPKRSVP
                     LTLLTGLVLLYTLVPLAWLVISATKTQEGLADSSGLWFAHDFALWDNISQTFTYDDGIF
                     VRWLLNTLLYVVLGAGGATLLAILGGYALAKFTFPGKRAVFAVVIGAVAVPGTALAVPT
                     FLMFSKMGLTDTPWAVIIPSLVSPFGLYLMWVFATEAIPVELLEAARIDGAGEVRTFFQ
                     VALPLLAPGIVTVLLFTTVATWNNYFLPLIMLKDPDWYPLTLGLSAWNAQAETIGGDVI
                     FNLVITGSLLTIVPLIIAFLLLQKYWQSGLAAGSVKE"
     gene            complement(23274..24200)
                     /db_xref="GeneID:41538138"
                     /locus_tag="SAVERM_RS05640"
                     /old_locus_tag="SAV_1030"
                     /old_locus_tag="SAVERM_1030"
     CDS             complement(23274..24200)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538138"
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522527.1"
                     /locus_tag="SAVERM_RS05640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_1030"
                     /old_locus_tag="SAVERM_1030"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_010982468.1"
                     /transl_table=11
                     /translation="MTTLQPSAAVSRPPARPPSKRDRRSWTGWGFIGPFAVVFAFVFLA
                     PIVYSIYLSVFRTQLIGGTTFVGLDNYQQALHDDQFWASLGRVSLFLAVQVPIMLGIAL
                     LIALALDSGRLYGKDFFRIAIFLPYAVPAVVATLMWGFMYGTRFGLVGDINEAFGVTLP
                     DPLSTDLVLASIGNIVTWEFVGYNMLIFYSALRVIPNSLYEAAEIDGAGQIRVITAIKL
                     PAIRGALVIATIFSIIGSFQLFNEPNILRPLARNAITTDYTPNFFTYSLSFNGQQHNYS
                     AAVAIIMGLITMVIAYAVQLRGMRKGA"
     misc_feature    24288..24305
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.46"
                     /tool="antismash"
ORIGIN
        1 cgaacggcac ggcgtcccgc tgctggtgac cgagcacggc gtgtatctgc gcgagcgcta
       61 cctcggctac cgcaccgccc cctaccgctg gcccgtgaag gccgtcgtcc tgggcttctt
      121 ccggctgctg gccgaagaga cctacctgcg ggcggcactg atcacaccgg gcaaccgcta
      181 caaccggctg tgggaggaac agggcggcgc ggaccccgag tcgatccgca ccgtctacaa
      241 cggcgtggac cccgccgcgt tcccgccggc cggccccgag ccggacgcac ccaccctcag
      301 ctgggccggc cgggtcgacc ccatcaagga cctggagacc ctgatccgcg ccttcgccct
      361 cgtacggtcc caactacccg aggcgcggct gcggttgttc ggcggcacac cgcgcggcgg
      421 cgaggcctac cgggagcggt gcgaggcgtt ggccgccgaa ctcggtcatg cggaagcggt
      481 cacgttcgag ggccgcgtcg acgacatcaa ggacgcctac gccgccggca acgtcgtgat
      541 gctctccagc atcagcgagg gtttcccctt caccctgatc gaggccatgt cctgcgggcg
      601 ggctaccgtc tccacggacg tgggcggcgt acgggaggcc gtgggcgaca ccggtctcgt
      661 cgttccgccg cgcgatccgg ccgccatggc cgccgccgcg ctgaagctgc tgggtgatcc
      721 cgagcggcgc cggtcgatgg gcgaggcggc acggctgcgg gtgatcgagc agttcacgct
      781 gcggcagacc gtcgacacct tccgctccat ctacctggag ctgtcggcgc ccggccggac
      841 gacacggcgc gacccatgga cgcccgacgc cgacgccggt ctctcgacga cggccggccc
      901 cgcggccgcg agaatgggga gcctggccgg atgagcggac cgatggcact cgaacccggc
      961 ggcacggaac aggacacgct ggccctcaga ctcgccgagg accgccccct cgccccgcga
     1021 ccgccggacg accacaccgt cgccctgcgc ctgccgggcc gcggcaccga ctccgacgcg
     1081 gtcgaccggc tcgccgccga actggccgac cgcatagggc ccgccgtcca ctcctacgag
     1141 gtggccgcgc tgctggagtc ggagggactg acggcggaga cgatccagga gcggtacggg
     1201 cacgcgaacc tgttcgcgct cgcctccacg ctgtacgcgc gcgtaccgcg tacctacccc
     1261 gagcccccgc ggccggccga cccatggcgc ccggaccatg tgcgatgcgc actgcgggga
     1321 gcgctgttcg cgctgccggg actcgcctat ctgctcaccg ggcggctgtg gcacgccgaa
     1381 cgcgacacgt ccgtgctgat cgtggccggg ctcgtctcct gggcctgggg ccaggcgctg
     1441 ggacaccggg cctatctgcg catgaccacg ggacggcggg aagcgggccg cacgctcctc
     1501 aaaggcgcac ccctgggtgc cgcggcggcc acgctggccg gggcggtgtt cgccggggcc
     1561 ggcacggtgg ccctgatcgc ggccgcgcag tcggtgtacc tctcggcggc cggcgtgctg
     1621 ctggtgctgg gccgcgagcg gctgctgctg gccgcgctca caccggtgat cgccggtgcg
     1681 gtggtgctgc cctggtggga accgggcccc gtactgcggg ccgggctgcc gctgctagcg
     1741 ctcctcgccg cgaccgccgc ggccggctgg tcgctgcggg tcaccctcgc ggcctccccc
     1801 gccccgggcg ccacccggcc cgggctgctg cggtcgctgc cgtacggcct gttcggcctc
     1861 gccgcggggg tgctggtgct gctggagggc cgccggcacc cgtacgccgt gatcgtgctg
     1921 accctgagca tggggccggc cgagtggctg ctgtaccgct accgcgggat gtcggtggcc
     1981 gcactacggg cgaccgcgac accggccgcc ttcctgctgc gttcggccgg cgtcctcggc
     2041 ttctgcctgc tcgcctatct ccttccgctg ctcccggcgg cgctgctcac cggtgccgag
     2101 ccggccccct tgctgctgct cgcggcgacc ctgtggaccg cgctgctgct ccaggccttc
     2161 ggcgtggcct ggccgccggc cggggtgtgc ctcgcggccg ccggcggggc cggggcgatc
     2221 accttgttcc atctcccacc gggcgctgcc gcgctgtcgc tgtgctgcgg cgcggccgcc
     2281 ctgtgtctca cggcgtgcgc gctgcggctg ctcgggcggc ccgccgcgca cgcctgaccg
     2341 caaggtccgc atcccgcacg ccaccgcact ccgctcgaca ccgcaccgcg tccggccgac
     2401 caccggacga caccggcccc cgacagaacg acatccgacg ccttgacacc acggacatca
     2461 cacgtgcaac cgaccggaag gaccatgagt tgacccccgc accgctcgcc gccgtcaccg
     2521 gagccgaggg tttcatcggc tcgcacctca ccgaggcgct ggtcgcctcc gggcaccggg
     2581 tgagggccat ggcgcaatac aactccttct cctcctacgg ctggctggag accctgcccg
     2641 cggacgtcct cgaccacgtc gagatcgtcc tcggcgacgt ccgcgacccc ggctcggtcc
     2701 gcgggctcgt cgaaggcgcc gactgcgtct accacttggc cgccctcatc gcgatcccgt
     2761 actcctacca ggcgccgcac agctacgtgg acaccaacgt caccggcacg ctcaacgtgc
     2821 tggaggccgt acgggccctc ggcacacccc gcctcgtgca cacctccacc agcgagacct
     2881 acggcaccgc gcagaccgtg ccgatcaccg aggaccaccc catcaacacc cagtccccgt
     2941 acgccgcgtc caaggcgggc ggggaccggc tcgccgacag ctatcacgcg agcttcgaca
     3001 ccccggtggt gacgctgcgc ccgttcaaca ccttcggccc gcgccagtcg atgcgggcgg
     3061 tgatccccag cgtcatcggc caggtggcgg ccggcgcgcg caccctcacc ctcggcgacc
     3121 tgcgccccac ccgcgacttc acctatgtca aggacaccgc gcaggccttc ctcgcggtgg
     3181 gcaccgcgcc cgccgcgcag gtggtgggcc ggaccttcaa cgccggcacc ggcggcgaga
     3241 tctcggtcgg tgacctggtc gggggcttga tcgggcaagg gtgaatggac gcctccctcg
     3301 acgtggcgcg gaggacgcgc agcgcatccg gcccgccaac tccgaggtga tgcggctggt
     3361 cgccgacgcg agccgcctga acgcggcgac cggctggagc ccggcccacg acctggagca
     3421 gggtctcgcg cacaccgtgg agttcttccg cgacccggcc aacctcgccc gctacaagac
     3481 cggcatctac aacatctgac ccgtccggca cgtccacgaa ggaggagccc catgcacgca
     3541 gtgatactgg cgggaggcaa gggcgtccgg ctgcggccct acaccaccgc gctgcccaag
     3601 ccgctcgtgc ccatcggcga ccagcacgcc atcctggaga tcgtgctgcg ccaactcgcc
     3661 gcggccggct tcaccggctg caccatcgcc atcggtcacc tgggcgagat catccgcgcc
     3721 tacgtcggtg acggctccca gtggggcatg gccgtcgact acgccaccga ggagagtccc
     3781 ctgggcacca tgggcccgct gctcaccatg cgcgagcgtc tgcccgagtc gttcctggtg
     3841 atgaacggcg acatcctcac cgacctcgac tacgccgacg tcctccggca gcaccgggac
     3901 tcgggcgcac cgctgacgat cgccacgtac gcccgcaagg tacacatcga cttcggggtc
     3961 ctgaccaccc aggccggccg ggtcgtcggg ttcaccgaga agccgagcat ggactaccgc
     4021 gtctccatgg gcgtgtacgg gctgtcccgg aagacgctcg acggctacac ccccgggctg
     4081 ccgctcggct tcgacgagct ggtgctggat ctgctcaaga cgccgaacct gccgcacgcg
     4141 tacgacttcg acgggtactg gctcgacatc ggccggcccg acgactacga ccgggccaac
     4201 gccgagttca ccactcgcaa gtcgctgttg ctcaagggag cctgaccacc gcatgcgcat
     4261 tctcgtcctg ggcttcaccg gctatctggg ccgtcacgtc gtcgagcggc tgcgcgccct
     4321 gccgggcaca cgggtgctcg gcggcggccg ctcggcgggc gcggagttcg gcatcgacct
     4381 cgccaccgct cgcccggaca cgctggcgaa ggccctggcg tcggccgcgc ccgacgccgt
     4441 gatcaactgc gcgggcgcga ccggcgggga cgccgtgacc ctcgccgaag tcaactcccg
     4501 tggccccgcc gtcctgtgcg cggcgctgcg ggaggcggcg ccctccgcgc gcctcgtcca
     4561 tctgggctcg gccgccgagt acggccccgg cacccgaggc atcagggtga ccgagtcggc
     4621 ggccacccgt ccccttaccc cgtacggcgc caccaagctc gccggcacga tcacgatcac
     4681 cacctccggc ctcgacgcgg tggtactgcg ggtgggcaac cccgtggggc ccggtgcccc
     4741 gctcaccggg ctgcccggcc gggtcgccgg actgctgctc gcgtcaggcg gtgacccgga
     4801 cgcggtgatc cggctgggtg acctgtcggc ccaccgcgac ttcgtggacg tacgcgacgt
     4861 ggcgcgggcc gcggtgctcg cggcgacggc accggcgccg ctgccgcgcg tcctcaacat
     4921 cggcagcggg agcgccgtgc cggtgcgcga cctggtcgcg gcgctgacac acgtcgcggg
     4981 attcccgggg agggtggagg agaagggcgg cggatccgca cgttcggcag aggtctcctg
     5041 gcagtgttcc gacatcggcg ccgccggtga caccctcggc tggcggccgt cgtacaccct
     5101 cgacgcctcc ctggccgcgc tgtgggcggc ggtcagggag gggccgtcgc cccggctgga
     5161 cgggggccgc gcgccgtgag cctcctgatc ccgctgtacg tccacccggc cgaggacccg
     5221 ggcgcgtggc accgcctgat cacggcggcc gaccgtacgt acgccgtcgt gctcaacccg
     5281 gcgaacggac cgggcacgag ccccgacccg gccttcgccg cggcggccgg cgcgctgcgg
     5341 gccgcgggcg cccgcctgct cggttacgtc gacaccaact atggcgcgcg tacggcggcc
     5401 gaggtcgcgg acgatgtcgt gcggcaccgg gagtggtacg cggccgacgg ctgtttcctc
     5461 gaccgggtga cctccgcacc ggccgaactt cccctctgca aaaggctggt gcagaccgta
     5521 cggcggctcg gcgcctcgcc ggtcgtgctg aatccgggcg tccatccggc gccgggatac
     5581 gcccgcctcg ccgatctggt ggtcaccttc gaaggccact ggtccaccta cgtgtcggcg
     5641 ttcagcagac cggcatggac cctgcggcac ccgccggagc ggttctgcca cctcgtctat
     5701 ggcgtgcccg aggccctcgt acccctcgcc gtgcgcaccg cacgcgagcg cggcgcggcc
     5761 gtgtgcggac cggtcacggg cgaaatcccc aacccctgga cgcgactgac acccgccctg
     5821 ggcgagacgg agcaatgaga catacggggt cggaacgcgc gtgtgtgagg ccctgggcaa
     5881 ggcccgaacc ggcgccggcc ggttcgggcc tccgccgtgc gcgggctagg tgggggttcc
     5941 agggctgtcg gggcgggcgg tgtggtcgcg gtggccgtgc gtgcggcggg cttccttcat
     6001 ctccgcctcg tacaggtggt cgcggccttc ggccagctcg ttcagcacgc tgcgttcgag
     6061 agccttgaac ggctcgtagt aggtgtcgtt gtaggactcg atgatctgga acgtccagtg
     6121 ccccgggatg acgttgcggc ccaggatctc cttctcgacc cggtcggccg accggtggtg
     6181 gccggctctg cgcagcagtt cgaccgcgtg accgagttcc agatccgcac cgccggtcag
     6241 ctgatggaag gagtacaggt ggccgcgggc ccgctcggtc gtctccagcg ccttggacag
     6301 tgcgcctagg gcttccactg tctcgtcgct gacacccgcg ggacgctggt ggtcacggtc
     6361 cgggccgtcg tgatcgctgt tcatgttcac ttcagtcccc cgcgccgccg cgcgcatgct
     6421 gttttcgcga cgctcaaggc ccggacggcg gacgcgagac atggcgtccg actcggtcgg
     6481 cgcagggtgg ccggccgcgt cgtcgccagg ccggtgacgg gcgcgtgccg cataatcggc
     6541 ccatgacagt gccccatccg gcagaacggt cccgccacgg gcggggctgg ttcgaaaagc
     6601 tggccgaggc ggcctccaat ctcaccagtt ctccggtctt ctactgtttc tgtctgctcc
     6661 tggtgttcgc gttcatcgtg gcgcacgcag tcggtctcga gctgacgtgg cagctgctga
     6721 tcggggacat catgaccgcc gtcaacctgc tgctgctggc cctgctgaag aactccgagc
     6781 gacgcgccga gcatgccatc cagcacaaac tcgacagcat cgccgccgcg ctgctcgaac
     6841 agcgcgaggg ccacagtcgc caggcgcacg aagagctccg taaagcgatc ggcatcgagg
     6901 acgaattctg accgcaccgc cgggccgggc tgcggtccac gcggactggc agtgccgcgc
     6961 cctgatctac cccttgtcgg cgcgcgaccg cagtatccag ggcagcagat accagcagaa
     7021 cgcgaaccac agcatcacgg caccggccag gatctcggcg agtgaactgg gcaggaccgc
     7081 gtgcaggatg agcaggacgg tgcatccgat ggtgagcgcg agcagtacga tgccgcccat
     7141 catcaagcgc ccggcggccg cgacgagttc atccttcatc cgctggccgg agaggaaacg
     7201 gtggatcgac acgggcgcta tgagcgcgcc ggtcgcagcg gccccgagga ggacggccgc
     7261 gacatagacg ccccggtcga acgttcccag ctcccggaac agcggggtga aggcgacact
     7321 gagcaggaag ccgaacagga tctgcacccc ggtctgcgcg acacgggttt cctgaaggat
     7381 ctcctgccac cgccggttga cccgctcctg ctcggattcg ccctcgtccg cacgtgtacc
     7441 ggagtcgctc gcacgcccct cctgagaagt gcgcgcctcg tcggacgacc gctgtctgcg
     7501 ctcgatcaaa ctcacggatc ttcctccaca atgggccatg gccgctgccc gtccggaccg
     7561 gcacgacaat cttcgcctca cacacgtgcc cgcattcggg cccgtcagac ggggttgcgc
     7621 agggcctcgc cggcgaaaga ccggatgacc cacggagccg gacgccgggc tatgcgctcc
     7681 cccaccgcgc cacccgtcgc agcacagcgc tacgccctcc gtccggtacc gtccacagcg
     7741 tctgaccgcg cacgccccaa cgctccaaca gggcgttcgc ggcgaggaaa ccgctggtcg
     7801 cggcgcgttc catcagcgct acgggcaggc cggtgcgcac caggtcaccg gccaccacca
     7861 gtcccggttc aggggtgcgt acggtcggtc ggtcgtggta tccgccgacg gggaacagcg
     7921 ggcagtcggc ccgccattcg tgccgctcgt cgacgaccgt cgccgcccgc gtctccgggt
     7981 acacccggca cagctgttcg agcatgcgct tctgctccac ctcgcggacc gcgtcctccg
     8041 gcagcgcgta cgcgtggagc tccaccacgg atccgccggt acgagccgac cagcgggcgg
     8101 cctcgccctc ccagcgctcc agcacactga cgttgtccag ggtcccgtat ccgctggtgc
     8161 ccaggaaacc gggccggtcc cgggcgacgg gccggtcgag ccacaggcgc gacaccagga
     8221 acggcggagc gttgcgcagc cgcgccatcc gctcgcgcca cggggcgtcg gccagggtcg
     8281 gggagcggcc ggccagggac cgcaggcccc ccgcgtccag ggccagcacg accgtgtcat
     8341 gacgccccgt ctcctccggc gtggcgacgg cgaacccgcc gtccctcgtg ggggcgacgc
     8401 tctcgaccga cgtcgaggtg cgcacctcga cgcggtgccg cagcagatag ccggcgaggg
     8461 ggtcccacag ggcggtcggg aacggttcgt ccggcacgtc gaagagcagt ccttcggagg
     8521 aacccaggaa gtagatgtgg aacatcagcg ccatctcggc cgcggacagc tccctggggt
     8581 ccgcgaagaa gctgcgggag aacacctcga acgccagatg gtgcgcggcc tcggggaaac
     8641 ggatcgaccg caggaagtcg tgggcgctga cggcgtccag acgcgtgtac acatcgggga
     8701 cgctgacgtc gagcaggggc agcgccgcca ccgggttcat gcggatcagg tcccgaaggc
     8761 cgaacgtggg gctgagcgcg acgaatccga gcgcgctcca cggcggggta cgcgggaccc
     8821 ggcggaagct gtcgtgcagc ccggcactgt gccggagcgg atagtcgggc agagccgtca
     8881 ggcgctccag ccgcggatcg gtccggcgca gcagcccgcg caggttgtag tactggcgga
     8941 agaaggcatg gaaaccgcgg ctcatcgtca ccgtggagcc gtcccgaagg ccgaccggcc
     9001 ggccggagag gcggccgccg aggtccggct gtcgttcgta gagggtgacg cgtactcccc
     9061 gttcggccaa cgcggtcgcg gccgccagtc cggcgatgcc gccgcccacg acggcggtcg
     9121 tggggggtcg tgctccgttg aaccgcgtcg ccccgggacg agggggcagc atccgggcgc
     9181 gccggtccct gccgcgacgt gcggcggccg gccgccggga gagggtcatc ggccggttgc
     9241 cgtgtcggtg cccgcgcgcc tgccgacgac ggtgtgggtg atgcccgtct gccaccccgg
     9301 cagcggcagc acccgtacgc agtcgaaccc ggccgcccgg acgcggccgg cgaactcgtc
     9361 cgccgtgtcg aactcgacga cgctgcgcca caggtggcgg tacagccgtc cgtcgccgag
     9421 ggccgtggcc acgggcagca cgatgcctcc gcatacgacc gtccacaccg ttcggtccct
     9481 ggcgcgaccg ctgagcgtgt agtcgtggac cgccagccgt ccctgcggtg ccagcacgtc
     9541 gtgcaccgcg gtgaggacgc tgtcgggggc ggccgcgttg cggaagaggt aggcggcgaa
     9601 caccgcgtcg aacggtccct cgacccccgc ctcggtcagg cgttccgccg gggcgtgcac
     9661 aaaggtcacg cggtccggcc agggcttggc ggccgcccgt tccagcatgc cggcggaggc
     9721 gtccaccgcg gtgatctcgg cgcccggcag gaccgcggcg agtgcggcgg tcgaggcacc
     9781 cgtaccgcag ccgagatcga gcacgcgcgt tccgctcccg ccgtgcggca gaccgaggcg
     9841 tcgggcggag cgccgaaggt gggcgtggta gccgggattg gccgccacca gagtgtcgta
     9901 gctgcgggcg gcgcggtcga acgcggcggc cagatccgcg tcgcgaagca gggtcatacg
     9961 gtctcctccg gcgggcgtgc gggccgtgtc cgcgtctcgg tcacggcccg ggaaagggac
    10021 ggcggggcag gtacggcagc tccgcggcgg agcggagcat cgggagtacg ggggtgtgca
    10081 ccccgatgga gaggtcctcg tggaggtgcg tgcagccgtc gaggaagcgc agcagccgct
    10141 ccatgggcac ccgtgagaag agccgcgcga agaaggccgc accgccgatc cggccgctgt
    10201 ccagggcgcg cagcagcacg gcgtccatgg cgcgggagcg ggcggaatgg gccggcggcg
    10261 gcagcgggcg gcggccgcgg cacagggcgg ccgcgacggc gcgcgtctgg cgctgcacgg
    10321 cggcgaaggt gtatcccgtc gacgggcgtg tcgcacctcc cgcggcgccg atccggaaga
    10381 ccgacgccgc ggtctgccgg gcgaacggcg cgtcggtcat gggaatcacg cccgtctcgg
    10441 tcgagacgat ctccaggccc ggcaggtgga ggatgtctcg cgtgtagtgc cgcagggccg
    10501 cctcgtaggc ggaccgcggc aggacggcgg gcgagaactc cgtgtactcc accagcgcct
    10561 gccggcggcc ggtgggcagc acgtatccga acgacagtcc tcgcgggggc tggggtgtgc
    10621 ggaagtccat gagctccacg gtgccggggt cgaagaccgg cagatcggag cggacgaacc
    10681 agccgtggaa atgctgcaac agcgtggtgc gggccgccgg gaggctgccg agcgggcgcg
    10741 agtcgaagac ccagcgggca cgcaccggca gcgggcgccc ggcggcggtg tacgcataca
    10801 cctcggcacc cccgggcacg ccctccaccg cttcgaccgt cgcctcgacg cgctggacgc
    10861 ccccgctcag cgcgaggtcg tgcgccatca gagcctcgaa gtcgtccgac cggatcatct
    10921 tgtaccgcag cggcgtgatg tcgccctcga tcggccgccc gccgggggcg cggacccgca
    10981 ggcgctgcca tgacgcggtg acagcggcgt cgtaccggcc ggggccccgc tcccagaagc
    11041 accacgtgcg cctcggcggc ctcagggggc ccggcggggc ctccagcagg accaccgaga
    11101 tgcggggcgc cccgcggaca gggcatgcca ggcggtgggc cagggacagt cccgcggctc
    11161 ccgcgcccac gatcgcgacg tccgcctcca gcacggcgtt ccctccttcc gcgcgagccc
    11221 atgcgccttg tcggaagcat tccgcttcgt gggccggtcc ggatgcaggg cgcgcggtcc
    11281 tgtcggccgt gcggctgact ccggcggccg aacgacccgg ccggcccggt gcggcggcgc
    11341 cgcccaccac cccgtcggcg ccgcccacca tcccgtcggc gccgcccacc accccgtccc
    11401 ggccgtctca gcgctccgca ttccctccaa tggcgcatcc gtgtgcgccg ccgacgcgga
    11461 atgcgttcag acaaggccag ctccgatcac gacgagagga accgggatgc gccgcagcaa
    11521 ggcgaccgat caccaggcgg ccggtccgtc accgggcccg cgcgacgcgt tccggccggc
    11581 ctccgtcgac gaggacgtac cggccgccgt gggccgactt ctcgaccgct tcctggcgga
    11641 gcgcgtggcg cgggcggcgg ccctcgaccc ggtgttcgcc cacgacatcg ccgagcgcgt
    11701 ggcgcggttc accctggacg gcggcaagcg cacccggtcc cagttcgtgt ggtgggcgca
    11761 ccgggcgtgc ggcggaccgg ccgccggggc ggaggcggcc ctgcgggtcg gtgccgccct
    11821 cgaactcatc cagacgtgcg cgctggtgca cgacgacgtg atggacggct cccggctgcg
    11881 ccgcggccgg cccgcgctgc acacggacgt gagtgcccag tacgccgacg ccgtcctgcc
    11941 cgccccgggc acacgcttcg gtgaggcggc cgcgatcctc gccggagacc tggctctcgc
    12001 ctgggcggac gacgtggtgg cggacaccga cctggcaccg gacccggggc gcagggtgcg
    12061 cgaggtgtgg agctgcctgc ggatggaaat ggtggccggg cagtacctgg acatccaggg
    12121 ccaggcgacc tcgtcgcatt ccgaggcccg cgcgatgcgc gccgcctgcc tcaagagcgc
    12181 gctgtactcc gtgcagcggc cgctcgaact cggtgccgcc ctcgccgggg cggacaccgc
    12241 cacgactcag gcgttgtgct cggcgggccg gtgcgtcggc ttggccttcc agctccgcga
    12301 cgacctccac gacgtcttcg aggaaccccg gcgcaccggc aagccgtcgg gcggtgacat
    12361 ccgggcgggc aaacccacct acctcgtcgc cgtggcgcgg gcccgggccg aagcggccgg
    12421 cgaccgcggc gccctcgccg tactgcggcg ctcgctcggt tgcgccgatc tgtccgacgc
    12481 ggacctcgcc cgggtgcggg acgtcctggt caccaccggc gcgcgtgaca cggtcgaggc
    12541 cgagatcgac cggctggtgg cccagggcct gcgccacatg ggcgccgcct cactcgcccc
    12601 cgagggacga cgccatctgg acgcactgct ccgttcagcg gccggtgcgc cctcggtccg
    12661 ccggcaggcc cctgacgcgt cccgctccga gaacgggatg cccgtatcgc tgctgctcac
    12721 cgccacggcc gagggggcct cccgatgaac aggacactgc gcgggcgcac cgaccacgtc
    12781 gtggtcgtcg gtgccggact cgccgggctt tccgccgctc tgcaccttct cggtgccggt
    12841 cgccgggtca ccgtcgtcga acgcgatctc ctgcccggag gccgcgccgg acgtctggtg
    12901 cgcggcggct acctcatcga caccggtccc acggtgctga ccatgcccga cctcgccgac
    12961 gaggccttcg cggcggtcgg cgacagcctg cgcgaccgtg tcgacctgat cccgctgcac
    13021 cctgcctacc gggcccgctt cgccgacggc agcaccctcg acgtgcacac cggcgccgag
    13081 gcgatggaag cggagatcga acgcttcgcc ggagcacgtg aggcggccgg ctaccgacag
    13141 ctgcgcgact ggctcgagcg gctgtaccgg gcgcagatgc ggcgcttcat cgactccaac
    13201 ttcgactccc ccctccagtt gctgaccccc gatctggcgc gtctggcggc gctcggcgga
    13261 ttcggccgac tggacgcgcg catcggccgc catctgcggg acgagcgcct gcgacgcgtc
    13321 ttctccttcc aggccctgta cgcgggcgta ccgccggccc gggccctcgc cgcctacgcc
    13381 gtcatcgcct acatggacac cgtggccggt gtgtactttc cccggggtgg catgcacgcc
    13441 ctgccgcggg ccatggcgga cgccgccgcg caggcgggtg ccgaactgcg cttcggacag
    13501 gacgtcaccc ggctggagcg ggccggtgac cgcatcaccg ccgtcgtgac ggcgtacgac
    13561 cggattccgt gcgacgccgt cgtcctcacc cccgatctgc ccgtcaccta ccgcctgctc
    13621 ggccgtgcgc cgcgacgccc gttgcggatc aggaactcgc cgtccgccgt ggtcctgcac
    13681 gcgggcaccg accggacctg gcccgggctc gcccaccaca cgctctcctt cggcgcggcg
    13741 tggggccgca cgttcgacga actcacccgc accgggggcc tgatgagcga tccgtccctg
    13801 ctcatcacgc gtcccaccgc caccgacccg ggcctcgcgc cgcccggccg ccatctccac
    13861 tacatcctcg ccccctgtcc gaacacggac atcgggccga gcgccgccgc atggggcgac
    13921 ctggcgccgc gctaccggga cagcctcctg acggaactgg aggcccgagg tctcgacggc
    13981 atcggatccg ccgtcgaaga ggagtgcctg gtcacaccgg ccgactgggc ggcccaggga
    14041 cacgccgcgg gcacgccctt ctcggcggcc cacaccttcg cgcagaccgg cccgttccgt
    14101 ccgcgcaacc tggtacgcgg gaccgcgaac gccgtgctcg ccggctgcgg caccacgcct
    14161 ggtgtcggcg tgccgaccgt gctgctgtcc ggcaagctgg ccgcagcccg tgtcaccggt
    14221 ggcacgaggc gcacaccccg ccgtatgccc gcctcccgca ccgcgagcgg aaggacgctt
    14281 tcatgaccga ccgcgaactc gatgcggcgg gcatcaccga cccgtcgctg cgcaaggcct
    14341 acacgcactg ccgccggctc aacgcgcggc acggcaagac gtacttcctc gccaccagac
    14401 tgctgccggt cgaacgccgg cccgccgtgc acgccctcta cggattcgca cgctgggccg
    14461 acgacatcgt cgactccctg gacaccaccg tcggccccgc tgtgcgctcg gcggcgctcg
    14521 gccgcctcca ggagagcctg cggacgggac tgcgtgaggg acacagcacc gagccggtgg
    14581 tcctggcgct cgccgagacg gcccggcggt acgcgatcga ccaccagcac ttcagtgact
    14641 tcatgacggc catgcgcagc gacctggagg tcaccggcta cgagacctac gccgacctgc
    14701 gcggctacat gcacggttcg gccgcggtga tcgggctgca gatgctgccg gtgctcggga
    14761 ccgtggtccc gcgtgaggag gccgcacccc acgcggcggc cctgggagtg gcgttccagc
    14821 tgaccaactt cctgcgggac gtgggcgagg acctggaccg cggccgcgtc tatctgcccg
    14881 ccgacctgtt gcgcgcccac ggcgtcgacc gggacctgct gcgctggagc agggacaccg
    14941 gccgccggga ccgccgtatc acccgtgcgc tcaaggccgt tgagggcctg acccgcggtg
    15001 tgtaccgcga ggcggcgccg gggcttgcga tgctcgaccc ggtggcgcgc ccgtgcatcc
    15061 ggacggcgtt cgtgctgtac ggcgggatcc tggacgccat cgccgacgac gggtacgcgg
    15121 tcgtccaccg ccgtgccgtg gtgccgcgcc ggcgccgtgc cgcggtggcg ctggacggtc
    15181 tcgtacgcct gggcgtggcc cgtctgggat cccgcgccga cgcgcggctg cccaccctgc
    15241 ccgatccgtg gcggcttccc gccctggtgc cgaggtcctc gccccggccg gcacatgagg
    15301 aggtcgcatg acccctgacc gcaccgaccg tcctgcccgg cgccgacgct acccgctctc
    15361 gttgcgcagg catccgattc gctgggagga ccagcgtccg acctggcgcg acgcgcggcc
    15421 cgccgtgatc gcggaggcgc tgaagcgggc gcaggcacga ccatcgggca actggtacgt
    15481 cgtcggcgcc acccgtgatg tgcgggagga ccgccctctg gcgcgcaccg tggccggcct
    15541 tgaggtcgtc gtctggcggg acggcgaagg gcggctggtc gccgggccag gtgtctgccc
    15601 ccatctcggt gcaccgctgc gggacagccc cgtgcgctgc ggcacgctca tgtgtcgctg
    15661 gcacggactc gccctgagcg gcacgccgtt cgcgggctgg gaaccgctgc ccgtgcacga
    15721 cgacggcgtg ctggtgtggg tacggctgga cgaggtcggc ggtgagcgac cgctcgaggc
    15781 cccggtggta ccggccaggc ctgccctgtc gggtgccgtg tcggccgtct acgtcggcgt
    15841 cggaatctgc gaacccgagg atgtcgtcgc caaccgcctg gacccctggc acggcgcatg
    15901 gttccacccg tactccttcg tcgacctcac cgtcgtcacg cccggggaaa ccgtcgcacc
    15961 tgaggaagga gaaacggagg gtgtagagac ggggggtgac gaggcggagg gcgccgagac
    16021 ggaggacgga tttaccgtcg acgtgtcttt caagatcgct ggacggctgg tcgtcccggt
    16081 gcgggccgtc ttcaccgctc cggagccccg cacggtcgtg atgcgcatcg cggaggggga
    16141 ggggcggggc tccgtcgtcg agacccatgc caccccgctc ggccctgacg accggggcag
    16201 gccgcgcacg gccgtggtcg aggccgtgct ggcgtcgtcc gaccgccgcg ggttcgccgt
    16261 ggcgcgcgcg atggccccgg tgctgcggcc actcatgcgc gctgccgccg gacgcctgtg
    16321 gcgcgacgac ctggcgtacg cggagcggcg ccggcacctg cgctccacgg gccgcttccc
    16381 cggctgaacg acaggcctgc ggtgagccga cggcccacac gatgccgcac gctcacgggg
    16441 gcggcggggt ggcgtacctg gcacaggcgg cggtgcctca ggccttcgga ccggagcacg
    16501 gaacgagttc cgccggatat gggcggggga gccattccga tgaccggacc cccgcgccat
    16561 gtcggctgcg ggggcccggt ccactcgtcc ggctcaaccg gtgcggctca cagcccgctc
    16621 gaccgagatc cgttctggtc ggtcacgtcg gtgaccgacc accgttggtt ggatccggag
    16681 ttcggcgtcc atgtcgtgac ggcggctccg tcggtggtgg cctggccgcc gacctcgagg
    16741 agcctgccgg tggcggcgtt gacgagggtc caggtgccgt cgccggtggt cgacatgatc
    16801 cactgggtgg ccttgtcacg gtggccgcgg tccgcctcca gcaccggcgc gccgtcacga
    16861 acggccaggc gctttcctgc cgcggggttg gtgaacacgt accgctgccg gttcccggtg
    16921 tcgccgctga tctgacgcac ctgccactgc tgcccggtcc cggccgcatc cgtacccgcg
    16981 gtcctgatga cgagctgggt gccgtcgtcc gcgacggtga gggccttgcc gctctggacg
    17041 ccggtcagct ggtaggtgtg ccccttgcac aggagcgcgg cgtccttcgc gacgccggac
    17101 actcccttga cgaggaagga cgtcacggac tgggcgggta cggtgaccgc ggcccggctg
    17161 ccggtgacct cgacgggggc ctgtcgttcg agcttgcctg cggcgctggt gaccacggga
    17221 gtcacggtcg cgtcgcgggt gatgtggccg aacttggaca ggtcgatcgt gacggtgcgg
    17281 gcgctggtgg tcttgttgac gtggacgacc gtcgccgcgt tgcccttcgt ggagaccgcg
    17341 gcggcgctgg aggtgtcgtc ggtcctgatc agtcggtcgc ccggcttgat gtagtgggtg
    17401 aagttgcggg cggtgtcgaa cttcgtgttc gtgtggacgg ggcaggtggc cagggtgtcc
    17461 gcggaggtgc agctgaacgg gagctggatg ctgccccagt tgccgccctt ggcggactca
    17521 ccgccgggct tcatgttgtc gtagtcctcg accggctgcc agaacaccca ggccttgggc
    17581 tcgagttcgc gcaggtcgtc gaccatctgc tgggcaagcc cgaggccggg ccgcatgtcc
    17641 gtgaagctct ggccgtcgcc ccagtcgccc tcgacctcgc tcatccacag cggcttgtcc
    17701 gccgccttgg ccaggtcgcg cacgctggtc cggccgccgg tgccgtaagt gtggacgttc
    17761 atctggccga cgagatcgcg cacgtcctgg gggtaggagt tccagttctg cgcgaagagg
    17821 ttcgggttgg tctcgtccat cgcggagatc ttcgtgccgg tcttcgcctt cttcagggcg
    17881 ggggccagcg cgcggatcac cttctgctgg agctccgggc cgatgtgagc cccttcctga
    17941 cggccgccga cgggccggcc gtcggatccc aggcgcgtac cccaatagcc cgtgttgggt
    18001 tcgttgaacg ggtcgagggt gtcgaccttg atgccgtgcg ccttctccag ccgcttggtc
    18061 gcgcctgcca gataggcggc gaagtcgtcg acggagtcgg ccttgagctg gtcttcgctg
    18121 gagttgaagc cgcccgacac atagccgctg gcggtcatga accagggcgg ggagttgctg
    18181 aacgtctccc agtggtcgat gtcgttcttg atccggtcca cccaccaccg ctgggtcgcg
    18241 tcggcgttgg ggttccagtc ggcggcgtcg tcggcgctcc accagtcggt gtcctcacgg
    18301 gtggtgcccg ccggggcgtt ccaccagccc tcgaccgctc cgccggcccg gaggtagtcc
    18361 ttgacgtcgg gggcgttgcc gccgccgatg ttgtagcggg cgatgttcag ggcgaggccg
    18421 tcgtcgtcga agaggagctc ggccagcttc tcgcgtatct ccgcgggata gtcgccggtg
    18481 gcgttggcga accagaccag gctggtgccc cagccctcga atctgtccgc tcggtacgag
    18541 gggtcgggct ggaccgtgac ggcagcggtc gccgctgccg ccggggtctg cgcgttcgtc
    18601 ggtggagcgg tgaccagggc tgccccggtg gccagggcgg tgacgccgat ggttcccaga
    18661 agccgtcgtg tgcgggtacg gcgtgccaac gtatgctccc cactcatctg tggtcgcttc
    18721 ggtggaccgt cgtggcctga gcgccaggac ggatggcctt cgaacaggtg cggtgccctt
    18781 cgagggcggt cagcgggtgg gctgccgcag aacggcgaca tcccgggggg acagcaccac
    18841 ggtgccgtcg tcctctgccc ggccgatcag gagttccccg gcgagtccgg tcagcggcac
    18901 cgtcccgtcg gtccggttga ccaggaacag atagcggctg ccggcgccgc ggcgcacgat
    18961 cagttcgacg tctcccccta cgccgtcggg cagttcactg ccgaccgcgg cagggccgag
    19021 cagcttcggc agcagtgcgg tgaggccgtc cggtcccagc cgggtggaca catacgcggc
    19081 cgaaccccgg cccaccgcac ggcgggtgac ggcggggtgg ccggcgtacg taccggtgcg
    19141 gtaccgggcc aggacctcca cctcggggtc ggtgacggtg atccggtcgg tccacagggt
    19201 gcccgtggcg gcgtcgtcca gtgcgaccgt gtcgccgtcg agcagcgggc cgaactcctc
    19261 gacgcggatg ccgagcagat cgcgcagggc tccggggtat ccgcccagcc agatgtggtc
    19321 gttctcgtcc acgacaccgg agaagtacgt ggtgaccagg tgcccgccgt tctcggcata
    19381 gcgggtgagt tccttggcca gtgccgcggg gaccacgtgc agcaccggcg tgatcaggag
    19441 ctggtaccgg tcgaggtcgg cctgcggggt gacgacgtcg gcccggatgc cgagggcgag
    19501 gagggcggag taccagtcga gcgcctcccg gcggtagtcg agcagggagg tggggtggga
    19561 gtcctgctca ctcgcccacc aggactccca gtcgaagacg atcccgaccc gcgccggttc
    19621 acgctcggtc ccggcgaccg gggccagcgt ccgaagggtg ccgccgaggg cggtcaccgc
    19681 gcggaagacc tcgctgtcgg gtccggcgtg cggcaccatc gccgagtggt acttctcggc
    19741 gcctgccgcc gactggcgcc actggaagaa gcacacggcg tcggcgccgt gcgcgacgtg
    19801 cagcagggag tcgcgggcca ggtcgccggg ccgtttggcc aggttgacgg gctgccagtt
    19861 gacggcgctg gtggagtgct ccatgaggaa ccacgggcgt ccgccggcta tgccgctgac
    19921 gaggttggcg gagaaggaca gctcgtcccg gtcctgaggc ccgggcgaga cgtagtggtc
    19981 gttggagacg aagtcgatct cctgggccca gtcggcgtag ttcatgccct tggtgcggcc
    20041 catcaccatg aagttggtgg tgaccggaac ctcgggcgtg atctcgcgca gcaggtcccg
    20101 ctccgcgcgc aggtacgcct tcagcgcgtc ggaggagaag cgcttgaagt ccagctgctg
    20161 cgtggggttc gggtgggagg cggccagccg gggcggcagg atctggtccc agtcgctgta
    20221 gtactgggac cagaacgcgg ttccccaggc gtggttgagg gcgtcgagcg tggtgtagcg
    20281 ggcgcgcagc cagtcgcgga aggcacgggc ggcgtcgtcg gagtagtcgt agatgttgtg
    20341 gcagcccagc tcgttggaga cgtgccatgc caccagcgcg ggatggtccg cgtaccgctc
    20401 cgccagcttc cgcaccaggc gcagggcgtg cgtgcggaag acgggggacg tgggacgcca
    20461 gtgctgccgc gcccccggcc acaccgtctc gccggaggcg gtcaccggga ggatctccgg
    20521 gtgtgccgtg gcgagccagg gcggcgggga cgcggtcgcc gtggccaggt cgaccccgat
    20581 gccgcccgcg tgcagcaggt ccatgacgtc gtcgagccag gcgaagtccc actggccctg
    20641 ggccggctgg atgcgggccc aggagaagat ccccaccgag acgatgttga cgccggcctc
    20701 gcgcatcagc cggatgtctt cctcccacac ctcgcgcggc cactgctcgg ggttgtagtc
    20761 ggcgccgtac gcgaggcgtg gcgtgcggtc accgtccggc ccgttcagct gggacaggag
    20821 ggtggagatc atcgtggtcc ttccggtgtg tcacaagggg gcggcgtggg gggcttgcct
    20881 cgactactcg acggtgaagc cctgttcctt gccgtacttg acggaggcgt cctgccagga
    20941 cttcagggcg tcggccagct tggtcttcga gatgtacgcc ttgccgacgg tgtcgttgaa
    21001 gatcgagttg gcgtactgct ggaagggcag gtacgaccag tcgtcggcga cgttggcggc
    21061 cgagtcggcg aagatcttgt tggcttcctg cccaccgaag tagtcgaact tggtgttctg
    21121 gaactcggtg gactggagtt ccgcggtggt cgcggggaag gcgccctgct tgatgcgggt
    21181 ctgcacaccg tcgccggcgt tcgcgtactc gacgaaggcg taggcgagtt ccttgttctt
    21241 ggccagctcg ggcacggtga gggagctgcc gccgttctcc gcgctcgcct tgtcgccctt
    21301 ggtccaggcc ggcagggggg cggctcgcca gtcgccagag gctttcggca cgccggtgac
    21361 gaagttggcg ggcatccagg cgccgctggg cagggtggcg atggtgccgt cgcccaggcc
    21421 cttgtaccag tcgtcggtcc agccgtagat gggtgcgacg agcttctcgt cgatgagctt
    21481 ctgccaggtg tcggtgtact tcttggcgcc cgcgtcggcg aagtcgatct tcaccttggt
    21541 gccgtcgacc tggtagggac gcgaaccggc ctgccacagc atgctggtgg tcaggcccgc
    21601 gtcgccggcg tcggcggcga tgtagacctt gggatcggcc ttgtgcagct tgcgggccgc
    21661 ctcgacgtac tcgtcccagg tggtcggcac cgcgaccttg tacttgtcga agactttctt
    21721 gttgtagaac agcgccatgg ggccggagtc catgggcagg ccgtagacct tgtcaccctc
    21781 gctcacggcg ttccacgggc cgggggtgta cttggccttg agcttgtccg cgccgaaggg
    21841 ggtcaggtcg gtgaggccct tggtgagcgc gtactgcccc agcgcgaagt actcgacctg
    21901 cgcgatgtcg ggaacgccct tctcggccga gatggcgttc gacagcgcgg tgtagtgctt
    21961 gtcgccggac cgctcgccga cgaggttgat cttgaccttg gggtacttct tctcgaagtc
    22021 ggcggcgacc gtcttgagcg tgggctccca ggcccagacc gtgaccgtgc cgcccttctt
    22081 cagggccgcc tggatgtccc cggcggagac cggcttctgg tcggcgctgt cgtcgtcgga
    22141 gccgccacag gcggtcgccc cgagggcgag gacggagagg acggcgaggc cgcgcatcag
    22201 gcggcgggtc gttctgcgca tggagatgct tccacttctt cgtgggtggg acggggcgag
    22261 ggtgagggag agggaaacag gtgaggctga ggggggtggg cctgagggtg ggtcattcct
    22321 tgacgcttcc ggcggcgagc ccggactgcc agtacttctg caacagcagg aacgcgatga
    22381 tcagcgggac gatggtgagc agcgagccgg tgatcaccag gttgaagatc acatcgccgc
    22441 cgatcgtctc ggcctgggcg ttccaggcgc tcaggccgag ggtcaggggg taccagtccg
    22501 ggtccttgag catgatcagc ggcaggaagt agttgttcca ggtcgcgacc gtggtgaaca
    22561 gcagaacggt cacgatgccg ggggcgagca gcggcagggc gacctggaag aaggtgcgca
    22621 cctcgcccgc tccgtcgatg cgggcggcct cgaggagttc gacgggaatg gcttcggtgg
    22681 cgaagaccca catcagatac aggccgaagg gcgagacgag cgaggggatg atcaccgccc
    22741 acggtgtgtc ggtcagcccc atcttgctga acatcaggaa ggtgggcacc gcgagggcgg
    22801 tgcccgggac ggcgacggcg ccgatgacca cggcgaagac ggcgcgcttt ccggggaagg
    22861 tgaacttcgc cagcgcgtag ccgcccagga tcgccaggag ggtggcaccg ccggccccga
    22921 gcacgacgta cagcagggtg ttcagcaacc agcggacgaa gatgccgtcg tcgtaggtga
    22981 acgtctggct gatgttgtcc cagagggcga agtcatgggc gaaccacagt ccggaggagt
    23041 cggccagccc ttcctgggtc ttggtggcgc tgatgaccag ccacgccaag ggcaccaggg
    23101 tgtagagcag gaccaggccg gtgagcaggg tcagcggcac gctgcgcttg gggcgtccgg
    23161 gaacatgctt gcggggcgtg cgcagtcggg gcgcgccctt ggtcgggccg gtggccggaa
    23221 cggatgcggg ctgggagtcg gtggtgacgg ggctgctcgt gctgctcatc gggtcacgct
    23281 cccttgcgca tgccgcggag ctgcacggca taggcgatga ccatggtgat cagccccatg
    23341 atgatggcga ccgccgcgga gtagttgtgc tgctggccgt tgaaggacag tgagtaggtg
    23401 aagaagttcg gggtgtagtc cgtcgtgatg gcgttgcgcg ccaatggccg caggatgttc
    23461 ggctcgttga agagctggaa gctgccgatg atcgagaaga tcgtcgcgat gacgagggca
    23521 ccgcggatgg cggggagctt gatggcggtg atgacgcgga tctgtccggc gccgtcgatc
    23581 tccgcggcct cgtacagcga gttcgggatg acccgcagcg cggagtagaa gatcagcatg
    23641 ttgtagccga cgaactccca ggtgacgatg ttgccgatcg acgccaggac caggtcggtg
    23701 gagagcgggt cgggcagggt gacgccgaag gcctcgttga tgtccccgac gagaccgaag
    23761 cgggtgccgt acatgaagcc ccacatcagg gtggccacca cggcgggcac cgcgtacggc
    23821 aggaagatcg ctatgcggaa gaagtccttg ccgtagaggc gcccgctgtc cagggcgagg
    23881 gcgatcagca gggcgatgcc cagcatgatc ggcacctgta cggccagaaa gagcgagacc
    23941 cgtccgagcg aggcccagaa ctggtcgtcg tgcagggcct gttggtagtt gtccaggccc
    24001 acgaaggtcg tgccgccgat gagctgggtg cggaagacgc tgaggtagat cgaatagacg
    24061 atcggagcca ggaagacaaa ggcgaagacc accgcgaagg ggcctatgaa cccccaccct
    24121 gtccacgagc ggcggtcccg cttcgacgga ggccgggccg ggggccgtga tacagccgct
    24181 gagggttgta gcgtcgtcat gtcgttcctc gctcgtccat ctcggaaccg gcgtcacacg
    24241 ccgtcgcgat gtttgcgtaa acatcgcgct ccgaaggaag ccgtgagctg ttatgtttac
    24301 gtaaacatct gatggcggca tgtctacact gccccaatgt tggtggtcaa gagtcgcttg
    24361 cgactcgtca tgagggagac gcgtgaacac ggcggacagc ggctcgacga gcgtgccgcg
    24421 ggcactgacg cgcatggatg aacagagcgc ccggcgcaga cagagtgcgt ccatggcgga
    24481 tgtcgcccgc ctggccggcg tctcctcgca gaccgtctcc cgcgtgtcca acggctacgc
    24541 gggcgtcacc gaagagaccc ggcaagaggt cctggcggcc atgaaggagc tgggctaccg
    24601 gcccaacagt gcggcccggg ccctcaagcg cggcgagttc cgcaccatcg gtgtcatcac
    24661 gttcaacctt tccaccacgg gcaacatgcg gaccctggag gcgatcgcca cctccgcggc
    24721 gcaggagggg tacgccgtca cgctcctgcc cgtggccgtc cccacccagg acgaggtgca
    24781 cggcgccttc tcccgtctgg gagagctcgc cgtcgatgcc gtcatcatca tcatggaagt
    24841 gcaccttctc gatgcggcga ccatctcctt gcccccgcac gtccaggtcg ccgtcgcgga
    24901 ctcggacgcc ggtgaccgtt acaccgtggt cgacaccgac caggcgggcg gagcccgcgc
    24961 ggccgtgcgg cacctgttgg aactcggtca ccgcacgatc tggcatctgg ccggtcccga
    25021 ggagtcgtac gcggcgcagc gccgtgccga cgcgtggcgc gccgaactca tcgaggcggg
    25081 ccgcgtcccg cccgccgtgg tacgaggcga ctggtcggcg gagtccggct atcaggcggg
    25141 gctgcggatc gccgacgagg aggactgtac ggcggtgttc gccgccaacg accagatggc
    25201 gctggggctg ttgcgggccc tgcacgagcg cggccggaga attccggagg acgtcagcgt
    25261 catcggcttc gacgacatcc ccgaggccgg ctccttcctg cctcccctga c
//
