LOCUS       NC_003155              20678 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1235691
            Orig. end                         :: >1256369
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..>20678
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..>20678
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..>20678
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:>10678](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..>10678
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(742..756)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     misc_feature    1034..1050
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.35"
                     /tool="antismash"
     gene            1222..2043
                     /db_xref="GeneID:41538083"
                     /locus_tag="SAVERM_RS05365"
                     /old_locus_tag="SAV_974"
                     /old_locus_tag="SAVERM_974"
     CDS             1222..2043
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-253). E-value:
                     2.5e-31. Score: 101.1. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS05365_Abhydrolase_1.1"
                     /codon_start=1
                     /db_xref="GeneID:41538083"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044023.1"
                     /locus_tag="SAVERM_RS05365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_974"
                     /old_locus_tag="SAVERM_974"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_010982412.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-22, bitscore: 79.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.6e-17, bitscore:
                     61.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTFTTDDGTEIFYKDWGSGPPVVFSHGWPLNADAWDVQLRLVAE
                     NGYRAVAHDRRGHGRSGQPWNGNHMDTYADDLSQLIGALDLRDAVVVGHSTGGGEVARY
                     IGRHGSGRVAKAVLVGAVPPIMLKTDANPEGLPIEAFDAIRAGVLSNRAQYYWDLSDQF
                     YGFNRPGAEGTDGVRRAFWLWSMQVGLKAAYDCIEQFSEQDFTEDLRRIDVPTFIAHGD
                     ADQIVPLVASAPKSAELVKDATLKVYSGAPHGLTGAYEQEFNADLLNFIRG"
     misc_feature    1255..1268
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.72"
                     /tool="antismash"
     aSDomain        1282..1980
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS05365_Abhydrolase_1.1"
                     /evalue="2.50E-31"
                     /label="SAVERM_RS05365_Abhydrolase_1.1"
                     /locus_tag="SAVERM_RS05365"
                     /protein_end="253"
                     /protein_start="20"
                     /score="101.1"
                     /tool="antismash"
                     /translation="PPVVFSHGWPLNADAWDVQLRLVAENGYRAVAHDRRGHGRSGQPW
                     NGNHMDTYADDLSQLIGALDLRDAVVVGHSTGGGEVARYIGRHGSGRVAKAVLVGAVPP
                     IMLKTDANPEGLPIEAFDAIRAGVLSNRAQYYWDLSDQFYGFNRPGAEGTDGVRRAFWL
                     WSMQVGLKAAYDCIEQFSEQDFTEDLRRIDVPTFIAHGDADQIVPLVASAPKSAELVKD
                     ATLKVYSGAPH"
     gene            <2133..>2249
                     /db_xref="GeneID:41544767"
                     /locus_tag="SAVERM_RS39785"
                     /pseudo=""
     CDS             2133..>2249
                     /codon_start=1
                     /db_xref="GeneID:41544767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058466.1"
                     /locus_tag="SAVERM_RS39785"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DUF1348 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSLAYTPGSRWRNRAEFVNGSAEIVGFLTRTWTREPDYR"
     gene            complement(2243..2434)
                     /db_xref="GeneID:41538084"
                     /locus_tag="SAVERM_RS05370"
     CDS             complement(2243..2434)
                     /codon_start=1
                     /db_xref="GeneID:41538084"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS05370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_037652674.1"
                     /transl_table=11
                     /translation="MTAAVVTPTTSSATPSTLAMSASHVRDGGSSPRRTMIGRSGRNGL
                     EAEIAQAGMVVRAATAGR"
     gene            complement(2431..4137)
                     /db_xref="GeneID:41538085"
                     /locus_tag="SAVERM_RS05375"
                     /old_locus_tag="SAV_975"
                     /old_locus_tag="SAVERM_975"
     CDS             complement(2431..4137)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358898.1"
                     /locus_tag="SAVERM_RS05375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_975"
                     /old_locus_tag="SAVERM_975"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_010982413.1"
                     /sec_met_domain="Pkinase (E-value: 1.6e-45, bitscore:
                     154.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEGETGRRVVDNRFELEARLGGGGMGTVWRARDLLLHRSVAVKE
                     VRPPDVDFAEYDPDGAHLLRERVLREARALARVEHPNVVTIHHIVDGGEGTYPWIVMEL
                     VGGGSLADRLARGPMTPAEAAHIGRGVLAALRAAHAAGVQHRDVKPANVLLRPDGSPVL
                     TDFGIAAIRESTTLTATGSIIGTPDYMAPERVTGDRGGPGADLWSLAMMLYVAVEGHHP
                     LRRGTTLATLAAVLHDDVPHPVKAGPLTPVLTRVLVRDPAARPDAEAFDRMLAAVAEAG
                     PGAEPTSYPLAPPVPAPPPATTESGLVGASRNPRDHLRRPAREPRDAVPDPRPPLGSDA
                     DRLGTRTVTRRPGRARLIVVASVAGASLVGGLVWRTLPGGQDGAAASPGASRETEHAPA
                     APTTVTQKPTDQESDSETTDLLTPAGIRASIKAIEKETGRDSFGDFSVYPDHVSASVMV
                     EGSRTRYDTYTYRVDRGVEKGIIKGTLAGGRQPVSLKNFQWDMVPALLARAERALKVEK
                     PTARYLLVRQPDNVFGTPAGMAVYLSNDYREGGYLEADTQGKVTKVMPAAG"
     gene            <4200..>4565
                     /db_xref="GeneID:41538086"
                     /locus_tag="SAVERM_RS05380"
                     /old_locus_tag="SAV_976"
                     /old_locus_tag="SAVERM_976"
                     /pseudo=""
     CDS             4200..>4565
                     /GO_function="GO:0030551 - cyclic nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003963.1"
                     /locus_tag="SAVERM_RS05380"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAV_976"
                     /old_locus_tag="SAVERM_976"
                     /product="cyclic nucleotide-binding domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MITELPVLRGYSDTAVLKEIATRFRTREVRSGQVLFEAGQPVTEA
                     YVIAHGRFTRYTAGKYGEEETIGVVTDGDQMGDEAIGQSDPLWLSSVRAETAGVVLVLP
                     WDVVTEFTERVPSLAAHL"
     gene            4619..5893
                     /db_xref="GeneID:41538087"
                     /locus_tag="SAVERM_RS05385"
                     /old_locus_tag="SAV_977"
                     /old_locus_tag="SAVERM_977"
     CDS             4619..5893
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612234.1"
                     /locus_tag="SAVERM_RS05385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_977"
                     /old_locus_tag="SAVERM_977"
                     /product="IS701-like element ISSav4 family transposase"
                     /protein_id="WP_010981725.1"
                     /transl_table=11
                     /translation="MDAHEVNRARATLALFVADVFASVPRKDQRAKGDCYLRGLMLDGR
                     RKSIQPMAERLPDGNEQNLQQFVNQSTWDPVPVRRRIAERMVAQIGPDAWAVDDVSFPK
                     DGKMSVAVAHQYCGALGKQANCQVAVSVHAVSDTASCPLQWRLFVPQEWAHDAPRRQKT
                     GIPPEVGHREKWRLALDIFDELAGWGLVPPVVVADAGYGQNADFRDGLDGRGIGYVAAI
                     RSDVTVHPHDAEPFAPPWSGNGRKPQPRYRDKPSSVAALATGHGRQAFTEVTWREGSRG
                     PMRSHFLSLRVRPAGVKSRRLAQAAATDENCWDGVLPEVTLLVEWPEGAEAPTDYWLSN
                     LPDTLSLAELVRLAKIRWRIEHDYRELKHGLGLDHFEGRSWTGWHHHVSLVTAAHAFLT
                     EQRLAPKAGTADSPSTRPSTPSRTC"
     misc_feature    4661..4663
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5993..7011)
                     /db_xref="GeneID:41538088"
                     /locus_tag="SAVERM_RS05390"
                     /old_locus_tag="SAV_978"
                     /old_locus_tag="SAVERM_978"
                     /pseudo=""
     CDS             complement(5993..7011)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050768036.1"
                     /locus_tag="SAVERM_RS05390"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_978"
                     /old_locus_tag="SAVERM_978"
                     /product="IS481 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTGKRPSLHRNAPLSVEGRRRLVERCKSRPIAHVAAEMGISRACA
                     SKWVNRFRRYGELGLHDRSSAPRHQPTATPAR"
     gene            complement(7008..7649)
                     /db_xref="GeneID:41538089"
                     /locus_tag="SAVERM_RS05395"
                     /old_locus_tag="SAV_7578"
                     /old_locus_tag="SAVERM_7578"
     CDS             complement(7008..7649)
                     /codon_start=1
                     /db_xref="GeneID:41538089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380524.1"
                     /locus_tag="SAVERM_RS05395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_7578"
                     /old_locus_tag="SAVERM_7578"
                     /product="membrane protein"
                     /protein_id="WP_010982417.1"
                     /transl_table=11
                     /translation="MNAFAQVRAAGKARRIPQLLLGLMGYGASVMLLVQSGLGAASWNV
                     LTEGTAKSLDISFGWATNLISLLVLIAWIPLRELPGLGTLLNVAIVGFAADATATVLPN
                     PQGPLAEIGYLALGLVALAFFDALYLGAQFGSGPRDGIMTGLVRLTHLPVALVRTGIEV
                     AVACVGWLLGGTVGVGTVLIALCMGPLVGCFLPLVAVHLPAVSAPTRHTR"
     misc_feature    complement(7642..7653)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    7731..7746
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.75"
                     /tool="antismash"
     gene            7780..9171
                     /db_xref="GeneID:41538090"
                     /locus_tag="SAVERM_RS05400"
                     /old_locus_tag="SAV_980"
                     /old_locus_tag="SAVERM_980"
     CDS             7780..9171
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (134-442). E-value:
                     4.8e-25. Score: 80.3. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS05400_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GeneID:41538090"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380525.1"
                     /locus_tag="SAVERM_RS05400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_980"
                     /old_locus_tag="SAVERM_980"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_010982418.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.2e-23, bitscore:
                     80.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISSHAVAGMLGTWQEGPGPAHQRLSDRLRLLILDGRLFLGAAL
                     PSERDLAVALGTSRTTVGTAFRTLVEHGYLATQARTRATVRLPDDTTPEHLVGTDAETI
                     DLSFAAPAAPVEILHAAFATALEQLPRHFERHGYDRYGTAELREAVARWYQRRGLPTRP
                     DHILITNGAQHALALLTRVLLSPRDKVLIDHPTYPHAITTFTQARARLLPVAVTSSGWD
                     TEQLQAAGQAANLAYLIPDFHNPTGMCMPTSVRQQLRLACPTVVDETMTDLALDVPSPE
                     PLALHMPTAISIGSVSKSVWGGLRTGWIRALPSLLERVEQARPTTDLGTPVVEQLATAV
                     LLNEHQTQRPDTLQQLRSQRDALWQALTEHLPNVHAPQPAGGVTLWAAFPGPVSSRLAA
                     MAPDHGVTIAAGPRFGIGGAFERNIRLPYTLPSSQLAQAIRRLAQAAQALAQGATGTHT
                     LAPIA"
     aSDomain        8182..9105
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS05400_Aminotran_1_2.1"
                     /evalue="4.80E-25"
                     /label="SAVERM_RS05400_Aminotran_1_2.1"
                     /locus_tag="SAVERM_RS05400"
                     /protein_end="442"
                     /protein_start="134"
                     /score="80.3"
                     /tool="antismash"
                     /translation="RHGYDRYGTAELREAVARWYQRRGLPTRPDHILITNGAQHALALL
                     TRVLLSPRDKVLIDHPTYPHAITTFTQARARLLPVAVTSSGWDTEQLQAAGQAANLAYL
                     IPDFHNPTGMCMPTSVRQQLRLACPTVVDETMTDLALDVPSPEPLALHMPTAISIGSVS
                     KSVWGGLRTGWIRALPSLLERVEQARPTTDLGTPVVEQLATAVLLNEHQTQRPDTLQQL
                     RSQRDALWQALTEHLPNVHAPQPAGGVTLWAAFPGPVSSRLAAMAPDHGVTIAAGPRFG
                     IGGAFERNIRLPYTLPSSQLAQAIRRL"
     gene            <9197..9984
                     /db_xref="GeneID:41538091"
                     /locus_tag="SAVERM_RS05405"
                     /old_locus_tag="SAV_981"
                     /old_locus_tag="SAVERM_981"
                     /pseudo=""
     CDS             <9197..9984
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003963.1"
                     /locus_tag="SAVERM_RS05405"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAV_981"
                     /old_locus_tag="SAVERM_981"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="HLDAYAERQRRPMNRKGEADVPVQAGHVGEPSLNGGFVDYDLAPR
                     EYELSLTQTVLRVHTRVADLYNEPMNQTEQQLRLTIEEIRERQEWELLNNREFGLLHNA
                     DYGQRISTFTGPPTPDDLDELLCMRRKTRLFLAHPKAIAAFFRQCNRRGLVPGTANIDG
                     HELPAGAASRCSPAARSRSPRSTPAASSRCAPGRPTKASSASIRPASRRSTSPV"
     gene            10001..>10678
                     /db_xref="GeneID:91294807"
                     /locus_tag="SAVERM_RS44540"
                     /pseudo=""
     CDS             10001..>10678
                     /codon_start=1
                     /db_xref="GeneID:91294807"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557597.1"
                     /locus_tag="SAVERM_RS44540"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="cyclase"
                     /pseudo=""
                     /sec_met_domain="T1TS (E-value: 1.3e-18, bitscore: 66.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASPLPGTSFAPPGPHDIAGTVRARRGGAIPGLRYRPAVPADPA
                     KVAETDRRLEAWARRLDVFPEAWFGDFAGFQFGRAVVLQHPGAADVERLTVAGKLLLAE
                     NIVDDCYCEDRGGSPRGLGGRLITAQSAIDPYHGTPEAEEQWRHGMQADGPLRSYHWAV
                     KDYATLATPSQTDRLVHDIARLHLGYLAEAAWAETRHVPRVWEYLVMRQFNNFRPCLSI
                     VEVA"
     gene            10743..11639
                     /db_xref="GeneID:41538092"
                     /locus_tag="SAVERM_RS05410"
                     /old_locus_tag="SAV_983"
                     /old_locus_tag="SAVERM_983"
     CDS             10743..11639
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538092"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433228.1"
                     /locus_tag="SAVERM_RS05410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_983"
                     /old_locus_tag="SAVERM_983"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_171033250.1"
                     /transl_table=11
                     /translation="MHCEEPLLTTAPDAVTAAPVPTQSTYQSRVADYWNAEENPVNLEL
                     GKIDDLYHHHYGVGAVDYSVLDEPDPSRRHERITAELHRLEHAQAELLAGHLSPLSPAD
                     RVFDAGCGRGGGSVVAHLRYGCHADGVTISAKQADFANEQARKRDIGDKVRYHHRNMLD
                     TGLPTGAFAASWNNESTMYVELELLFAEHARLLRRGGRCAVIIGCYNDTYGRASREVSL
                     INAHYICDIHPRSAYFRAMARNRLVPVHVEDLTGAALSYWELRKRSDRLATGIEDSFRT
                     AYKNGSFQYLLIVADRV"
     gene            complement(11730..14543)
                     /db_xref="GeneID:41538093"
                     /locus_tag="SAVERM_RS05415"
                     /old_locus_tag="SAV_984"
                     /old_locus_tag="SAVERM_984"
     CDS             complement(11730..14543)
                     /codon_start=1
                     /db_xref="GeneID:41538093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562025.1"
                     /locus_tag="SAVERM_RS05415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_984"
                     /old_locus_tag="SAVERM_984"
                     /product="DUF5682 family protein"
                     /protein_id="WP_010982422.1"
                     /transl_table=11
                     /translation="MSGTHGQTFEELRGQLQEAAATFSDGPDALEGILLGIVDDVDRAV
                     REPLEIFPVCHHSPASALAMARRLREKRPKVVYLELCEDMAPLLTELRNCRLPVAVQAF
                     ATEVDGFPADWSPLSVVAPITEASAEYQAIAYALDTPGVELVLVDRSSDHVFQWDSRGT
                     HSAEAGADPGASDAPPVEEEAALHGDAVGVEIGDLRPRFAELEEHLLHHGRVRHWSEWW
                     HQYVELPLGDSDHDTYRQVMLLIGSLFRRLAPGDPHRVRVDEDRERYMWTRMREHLAAT
                     GTDAADCLYVCGAFHAASRVAEFGVHGTDTFEIGPRSATRWQHGLIPSSHAAIETQFGL
                     ASGSVSIAATVWAKNVRRTRVEPFRLAGQAGAKTSKAKKTAVAAAPVPAAANSDKLTGF
                     LRRPPVLDRLDETELLGWSVEIVRAARRNGYLASTADAIAVFETSILLAGMRDRARPTP
                     YDFQDAAVTCIEKDTVPGRRDVRRLVDIMMGGDRIGQVGYDALPPLARDVHDRLAPLNL
                     KLQQRGVQRALLDISSQPQLEQCSDVLWMLRYLMPQGTARPIMGERRLGERPIQESWDL
                     ALGTHQRALIELGYEGVSIEQVLEQRLRRTAYGPHATTATVLEAIEDATLHLRSRRLTD
                     ELGTRALEVLSAERSVDGAPEVLRRVRRLLAYYRTSEPVLPPWIESFVKTGYAHYCTLL
                     PTAFTDDDATVRQVAAMLGFLFGMESLALSLGCDRTQLELSVAQSHPQEPSKVALLWAA
                     QVQLGHLSRADLRTRCDELLDNPMVVPAYPRYLSGFVHALEPVPGLADLVVEAVSNAFG
                     RLPDPVLLPWLPTLISTLRSNGAELAPLLIREAGRIFPGRLGELDAWVPPWRAQPLPDT
                     ARPGGRAGEGRNVALLAAHPATCDAVASLLGCDGTWQTADPGPAGGQLIGRHPDTAVAL
                     ESLLATP"
     gene            complement(14540..15652)
                     /db_xref="GeneID:41538094"
                     /locus_tag="SAVERM_RS05420"
                     /old_locus_tag="SAV_985"
                     /old_locus_tag="SAVERM_985"
     CDS             complement(14540..15652)
                     /codon_start=1
                     /db_xref="GeneID:41538094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960997.1"
                     /locus_tag="SAVERM_RS05420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_985"
                     /old_locus_tag="SAVERM_985"
                     /product="AAA family ATPase"
                     /protein_id="WP_037650305.1"
                     /transl_table=11
                     /translation="MSDLLRAPAEIKYAEELDWLESIDDNPKPFSWRLSPKMVRLFILG
                     SERSDGLEREISQKWFGDRSFVERSIVTLASDRGLLLIGDPGTGKSWLAELLSAAICRN
                     STLVVQGTAGTTEDHIKYSWNVSMVIAKGQSRESMIPSPIMTAMETGAIGRFEELTRST
                     SDVQDALISILSEKYVSVPELDSDSVVFAQPGFSIIATANSRDRGVNDLSSALKRRFNF
                     VRIPVMTNRKSEAEIVRFRTEELLRRHQIELDVPPTLLDVLLQSFADLRASAAAAGSDD
                     EKLESALSTAEQIGVLEDAILHSNFFGERALTARTLASSLVGSLARREPEDLAILNKYL
                     HGVVEPRGKEEGGSWPEFLEGGRDAIATLS"
     gene            complement(15665..17101)
                     /db_xref="GeneID:41538095"
                     /locus_tag="SAVERM_RS05425"
                     /old_locus_tag="SAV_986"
                     /old_locus_tag="SAVERM_986"
     CDS             complement(15665..17101)
                     /codon_start=1
                     /db_xref="GeneID:41538095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713095.1"
                     /locus_tag="SAVERM_RS05425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_986"
                     /old_locus_tag="SAVERM_986"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_010982424.1"
                     /transl_table=11
                     /translation="MTERTTEHTPEQNAEADSDENRRQVLYWRLLARLFDHEEQATLES
                     ASLAVVEDIGLPSGLLDPGTSVDSIVQRHPELASEFDGLMVPEPEPDDDGRDRAAEVRR
                     AALVSKVLLNVFAAGSGTVTAGQLSRWQSDAGWLERALGCRPGELRGGRPGGGRAGRGA
                     GPAGTGGRGATPDLGRLIPAIGPELGAIEADLVKRMHLREVLADPTLAAQLTPSMSLIE
                     QLLRDKNNLSGVALANAKALIRRFVDEVAEVLRTQVAQATAGALDRSVPPKRTFRNLDL
                     DRTIWKNLTNWSPEEERLYVDRLYYRHTARKTTPQRLIVVVDQSGSMVDSMVNCTILAS
                     IFAGLPKVDVHLIAYDTRAIDLTPWVSDPFEMLLRTNLGGGNDGPVAMAMARPKITEPR
                     STVMVWISDFYEFDRSQPLFEGIEAVHRSGVKFIPVGSVTSSGRQEVNPWFRERFKALG
                     TPVVSGHIRKLVHELKTFLA"
     gene            complement(17098..18528)
                     /db_xref="GeneID:41538096"
                     /locus_tag="SAVERM_RS05430"
                     /old_locus_tag="SAV_987"
                     /old_locus_tag="SAVERM_987"
     CDS             complement(17098..18528)
                     /codon_start=1
                     /db_xref="GeneID:41538096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453045.1"
                     /locus_tag="SAVERM_RS05430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_987"
                     /old_locus_tag="SAVERM_987"
                     /product="hypothetical protein"
                     /protein_id="WP_037650303.1"
                     /transl_table=11
                     /translation="MVPADQGGGVMRTDLLTEPMAGLDEALAAVDGFDRTLVGGLLRPQ
                     PAQAADLNQLACAVAGTPLASRVAEAADKAAAGAASEDHFVALAAARTALLGSVHDALM
                     TRVDEVIGRTRGEATASTPGERHMVNLLAAARSWLCDLARAGWQGIDHEVVSASAQVVS
                     SMLPDPSLRRLATLLDGFAAELAASCPGAALKRMPVRRWGDVWSRAMLLTVPGAADAPT
                     TAPATGRLLPLGVDVHEHATAAQAQVHAVFEPADGSAPRLVRASVSVPKPDTVVGAGVW
                     QLLRPHMSLLAAAGEGRSMELHAMPITAEGDLIWSDEQGRPGEPADPFATARVVLPTAT
                     AAHTAPLHRHPAGIAVPVFLEGYAVHKDGDVLTFNTAGHGHGHGLAVEADRVPTTGPLT
                     PEAVALSNACIGLLRWDTGAFSVQPLAVETTVRKKAVAVHAGAWAGGTADKTGAKAEKA
                     ATEAVAVLRERAGRLLRK"
     gene            complement(18498..18977)
                     /db_xref="GeneID:41538097"
                     /locus_tag="SAVERM_RS05435"
                     /old_locus_tag="SAV_988"
                     /old_locus_tag="SAVERM_988"
     CDS             complement(18498..18977)
                     /codon_start=1
                     /db_xref="GeneID:41538097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010360876.1"
                     /locus_tag="SAVERM_RS05435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_988"
                     /old_locus_tag="SAVERM_988"
                     /product="hypothetical protein"
                     /protein_id="WP_010982426.1"
                     /transl_table=11
                     /translation="MARVIPPARPRKLAKVPFVELADGRLQGVVSSGSDIERVYVSSVA
                     AGSYAFACSTNNNRPCGGARGSFCNHIKALINEAVLQYGVERVVRYLRVDIADEERSAQ
                     GIAAEMSGTNPPQGDAKAAAWVFSRFLRHLAYLELAPTTAPLPEMQWFPPTRAVA"
     gene            19255..20178
                     /db_xref="GeneID:41538098"
                     /locus_tag="SAVERM_RS05440"
                     /old_locus_tag="SAV_989"
                     /old_locus_tag="SAVERM_989"
     CDS             19255..20178
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41538098"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563702.1"
                     /locus_tag="SAVERM_RS05440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_989"
                     /old_locus_tag="SAVERM_989"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_010982427.1"
                     /sec_met_domain="APH (E-value: 9.7e-33, bitscore: 112.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTPPDGRSGIDAALVSRLIAAQFPQWSGLPVTPVDIDGWDNRT
                     YRLGDDMTARLPTAAGYVPAVTKEHEWLPRLAPSLPVAIPPILAMGVPGEGYPFPWSVR
                     GWLPGERADRGRIDDLSQFAVSVAEFVLALQRCDTTGGPLAGEHSWYRGASPAHYDDET
                     RRCLAALEGRVDTDRAATVWGAALAAPWDGNPVWFHGDVGAGNLLVADGKLAAVIDFGT
                     SGVGDPACDLVIAWGMFSGDSRDAFRRAVGQDEGTWARARGWALWKSLLTLAECIDTDP
                     EQAAVNRRLIGHVLEDHRRFAQPSVA"
ORIGIN
        1 aacggcaagc ccgtcttcat gatggccacg ctcgaccagg gtttctggcc cgacggcctg
       61 cacaccgcgc cgaccgacga cgcccttgcc cacgatctga agatgcacaa gcagatgggc
      121 ttcaactccg tgcgcaagca catcaaggtg gagcccgacc gctggttcta ctgggcggac
      181 aggctcggac tcctggtgtg gcaggacatg cccgcgatga ccgccggggt gaacccgaac
      241 gccgcctccc gcgccgagta cgagcgcgag atgaagcagc tgatcgacga gcacatcagc
      301 agcccctcgg tcgtcatgtg ggtgaccttc aacgagggct ggggccagta cgacgaggcc
      361 cgcatcgccg accaggccaa ggcgtgggac ccgacccggc tggtcaacag catgtcgggg
      421 ctcaacctcg gggttgacgg cggcaccggc gacgtcatgg acgagcacgg ctaccccagc
      481 cccgcgctgc cgccgcaccc cgacggcaga cgggccctgg tcagcggcga gtacggcggc
      541 ctcggcctgg gagttcccgg acacgcctgg tcggtgcaga tgtcgtacgt ggatgtcgac
      601 cccgccgcgt acaccgacac gtatctggcc cggctcgacg aggttcgcag gcttgcctgc
      661 cggggcggca atggagccgt ctacacccag atctccgacg tggagggcga gctcaacggc
      721 ctgatgacct acgaccgcaa gatcgtcaag cctgatgtgc agcggctcag gaccgcgcac
      781 gaggcactga tcgaggcagt ggcgcagtcc acgctcccgt gcgccacgtc ctgaccccct
      841 gacggcgccg ggcgacggtc cgcctgcccg ctccccttcc ggcgcgggcg ggcgggccgt
      901 cggccccacc cgcacgagcg gaccctccgc agggctcttc accgccgtcg cggcagcgcg
      961 cggacggtgg gaggtggccg tgaccggcgc tgtggcgcgc agggctcttc cgtcttatgg
     1021 tcgaatggtt caccgcacat ctccggcgcg gcaccgctcg cgtccgcgta gcgctcgcga
     1081 gccgggaggc gctgtccgta cgccgctgtc gaccggacga gacagtcgca ttgaatacga
     1141 ccgctcacgg ctgtcgtgag ccgcggcgga ctgcgtctct ttcgttctgc gccaacagcg
     1201 gtcagaggga agaccggcac catgggcact tttaccaccg atgacggcac agagattttc
     1261 tacaaggact ggggcagcgg accgcccgtc gtgttcagcc acggctggcc gctcaacgcc
     1321 gacgcctggg acgttcaact gcgtctggtg gccgagaacg gctatcgcgc ggttgcccac
     1381 gaccgccgtg ggcacggccg ctcgggccag ccgtggaacg gcaaccacat ggacacctac
     1441 gccgacgacc tctcgcagtt gatcggcgcc ctggatctgc gggacgcggt tgtcgtcggc
     1501 cactccaccg gcggcggtga agtggcccgt tacatcggcc ggcacggcag cggccgcgtt
     1561 gccaaggcgg tcctggtggg agccgttccc ccgatcatgc tgaagaccga cgccaacccg
     1621 gaggggctcc cgatcgaagc cttcgacgcc atccgtgcgg gcgtcctgag caaccgcgcc
     1681 cagtactact gggacttgtc ggatcagttc tacggtttca atcggcccgg cgccgaaggc
     1741 acggacgggg tacggcgcgc gttctggttg tggagcatgc aggtgggact caaggcggcc
     1801 tacgactgca tcgagcagtt ctcggaacag gatttcaccg aggacctgcg gcgcatcgac
     1861 gtaccgacct tcatcgcgca cggcgacgcc gaccagatcg tccccctcgt ggcgtcggca
     1921 cccaaatctg ccgaactcgt caaagacgcg acgttgaagg tctattcggg ggcgccgcac
     1981 ggtctgaccg gggcatacga gcaggaattc aacgctgacc tgctgaactt catccgtggc
     2041 taggcggcaa tgtgagggac gaccggtaca gatccgcccg gggttcttcg gcgccggccc
     2101 cgctctcgcg cgggtccggc gtcgcctgag ggctgtccct ggcgtacacg ccgggctcgc
     2161 gctggcgcaa ccgcgccgag ttcgtcaacg gcagtgcgga gatcgtcggc ttcctcacgc
     2221 gcacgtggac acgagagccc gactaccggc cggcggtcgc cgcccggacg accatgccgg
     2281 cttgagcgat ctcggcttct aggccgttcc gtccggagcg tccgatcatg gtccggcgcg
     2341 gcgaactgcc gccgtcccgc acgtgcgacg ccgacatcgc gagtgtgctg ggcgtcgccg
     2401 acgacgtcgt cggcgtcacc accgcggccg tcatccggcg gccggcatca ccttggtcac
     2461 cttgccttgc gtgtcggcct ccaggtagcc gccctcccgg tagtcgttgc tcagatagac
     2521 cgccatgccc gcaggagtgc cgaatacgtt gtccggctgc cggaccagca ggtagcgggc
     2581 cgtcggcttc tcgaccttca gcgccctctc cgcacgggcg agcagcgcgg gaaccatgtc
     2641 ccactggaaa ttcttcagac tcaccggctg tcggccaccc gccagcgtgc ccttgatgat
     2701 gcccttttcc acgccgcggt cgacacggta ggtgtaggtg tcgtagcggg tacggctgcc
     2761 ctcgaccatg accgacgccg agacatggtc cgggtagacg gagaagtcac cgaagctgtc
     2821 ccgtccggtc tccttctcga tggccttgat cgaggcccgg atgccggccg gggtgagcag
     2881 gtcggtggtc tcgctgtccg actcctggtc cgtcggcttc tgtgtcacgg tcgtgggcgc
     2941 tgccggggcg tgctccgttt cgcgggaggc cccgggcgac gccgcggctc cgtcctggcc
     3001 tccgggcagc gtccgccaga ccagcccgcc cacgagcgac gcaccggcga cggaggccac
     3061 cacgatgagc cgtgcccgtc ccggccgacg ggtgaccgta cgcgttccga gacggtcggc
     3121 gtcggacccc agtggtggac gcgggtccgg tacggcgtcc cgtggttccc gcgccggccg
     3181 cctcaggtgg tccctcgggt tccgcgacgc tccgacaagc ccggattccg tggtcgcggg
     3241 cggcggtgcc gggaccgggg gtgcgagtgg gtaggacgtg ggctcggccc cgggaccggc
     3301 ttccgccacg gcggcgagca tccggtcgaa ggcctcggcg tccggccgcg ctgcggggtc
     3361 acgcacgagc actcgcgtga gtaccggcgt caacggaccg gccttcacgg ggtgcggtac
     3421 gtcgtcgtgg agcaccgcgg caagcgtggc cagcgtcgtc ccccggcgca gcggatggtg
     3481 cccctcgaca gcgacgtaca gcatcatcgc cagcgaccac aggtccgcac cggggccacc
     3541 ccgatcgccc gtgacgcgct ccggcgccat gtagtcgggc gtgccgatga tcgatcccgt
     3601 ggcggtcaga gtggtggact cgcggatcgc ggcgatcccg aagtccgtga gcaccggact
     3661 gccatcgggg cgcagcagca cgttggcggg tttcacgtcg cggtgctgca ctcctgcggc
     3721 gtgcgccgca cgcagggctg cgagcactcc gcgcccgatg tgcgcggcct ccgccggggt
     3781 catcggccca cgagcgagcc ggtcggccag cgacccgccg ccgacgagtt ccatgacgat
     3841 ccatgggtag gtgccctcgc cgccgtcgac gatgtggtgg atcgtcacca cgttcggatg
     3901 ttcgaccctg gccagggcac gagcctcgcg caggacccgt tcgcgcagca ggtgcgcgcc
     3961 gtccgggtcg tactcggcga agtccacgtc cggcggccgt acttccttga cggccacgct
     4021 ccggtgcagc agcagatcac gggcccgcca cacggtgccc atcccgccgc ccccgagccg
     4081 ggcctccagt tcgaagcggt tgtccacgac ccgtctgccg gtctccccct cacccatacg
     4141 caggagctta aggggcactg tcgagccccg ggcctccagg gggccccgcg gcgaacgcaa
     4201 gcatcaccga actgccggtc ctgcgcggct actccgacac ggctgtgctc aaggagatcg
     4261 ccacccgttt ccgtacccgg gaggtgcgga gcgggcaggt cctcttcgag gccgggcagc
     4321 ccgtcacgga ggcatatgtg atcgcccacg gccggttcac ccgctacacc gccggcaagt
     4381 acggcgagga ggaaaccatc ggggtcgtca ccgacggcga ccagatgggc gacgaggcca
     4441 tcggccagtc ggaccctctg tggctgagct cggtccgggc cgagacggcg ggcgtggtgc
     4501 tcgtgctccc ctgggacgtc gtcacggagt tcaccgagcg ggtgccgtcc ctcgcggcgc
     4561 acctagtagg gctccgttag gtctgtctcg cggtcctgtt tgggggcatg ttgaaggtgt
     4621 ggatgcacat gaagtgaacc gtgctcgggc gacgttggca ttattcgtgg ctgacgtgtt
     4681 cgcgtcggtg ccgcgtaagg accagcgggc gaagggcgac tgctatctgc gggggctgat
     4741 gctggacgga cggcgtaagt cgatccagcc gatggcagag cggctgccgg atggcaacga
     4801 gcagaacctg cagcagttcg tgaaccagtc gacctgggat ccggtgccgg tgcggcggcg
     4861 gatcgcggag cggatggtgg cgcagatcgg cccggatgcc tgggcggtcg atgacgtgtc
     4921 gttccccaag gacggcaaga tgtcggtcgc ggtcgcgcac cagtactgcg gggcgctggg
     4981 caagcaggcc aactgccagg tcgcggtgag cgtgcacgcg gtctccgaca ctgcctcctg
     5041 cccgctgcag tggcggttgt tcgtgcccca ggagtgggcg cacgacgcgc cacggcggca
     5101 gaagaccggg ataccgccag aggtcgggca ccgggagaag tggcgcctgg ctctggacat
     5161 cttcgacgag ctggccgggt gggggctggt gccgccggtg gtggtggccg acgccggcta
     5221 cgggcagaac gccgacttcc gcgacggcct ggacggccgg ggcatcggct atgtcgcggc
     5281 catccgctcg gatgtgaccg tccatccgca cgatgccgag cctttcgcgc cgccctggtc
     5341 gggcaacggc cgcaagcccc agccccgcta ccgcgacaag ccgtcctcgg tggcggcgct
     5401 ggcgaccggc cacgggcggc aggccttcac cgaggtgacc tggcgggaag gctcccgcgg
     5461 accgatgcgc tcgcatttcc tgtccctgcg ggtgcggccg gccggggtca aatcccgacg
     5521 cctcgcccag gccgccgcca cagacgaaaa ctgctgggac ggtgtcctgc ccgaggtcac
     5581 actgctggtc gaatggcccg aaggcgccga ggcgcccacc gactactggc tgtccaacct
     5641 gcccgacacg ctctccctcg ccgaactggt ccgcctggcg aagatccgct ggcgcatcga
     5701 gcacgactac cgcgaactca agcacggcct cggcctggac cacttcgagg gccgctcctg
     5761 gaccggctgg caccaccacg tctccctggt caccgccgcc cacgcgttcc tcaccgaaca
     5821 gcgtctggcc ccaaaagccg gtacagcgga ctcaccctct accagaccct cgacgccatc
     5881 caggacctgc tgaactgctg gagcggcacc tgcaccacct gccaccgccc cctgcccaaa
     5941 acatccacca ccagccacaa cccaagagcc agagcaacct aacggagccc tactaggtgt
     6001 atgaggacag gacgttggtg acggtcatgg gcaggcggat tgccggtggc tggtttccag
     6061 ctgccccgtg tgggcggtgg tagttgtagt ggatgttcca gacgcggagc gcatctgagc
     6121 gttcttgctc gcattgccag ctccgggcgt agaggaattc ctcggcgagg atgcggtggt
     6181 accgctccac tttgccgttg tggcgaggtg tgtatggggt gatgcgttgg tgccgtgctc
     6241 caagcagcgc gcgagcgaag gcatcggctc ggtagcaggc tccgttgtcg gtgacgatcc
     6301 gctcgatggt ggtgatgcca tgcgctgcga accagacgcg agcgcggtgc atgaatgcaa
     6361 tggcggtggt ggccttctcg tttggcagtg cctcggtgta ggccagacgc gaaaagccgt
     6421 cgatggcgga gtgcaggtag atgtagccgc gacggccggt tcggcgtttc tgccgttctg
     6481 cagatttggc ctgcgtgctt ccgcggccgt ggactcgcca gcctccgcca tcggggatgc
     6541 ggccggcttt cttgacgtcg atgtgcacca tgtgacccgg gcggtgggcg atgatctgcc
     6601 gcgctgtgcg gttggactcc ccgtccggat cgatgaaccg acggcgactc agcccgagct
     6661 gttccagatg tcgcgtgatg gtccggcgac tgatctggat gccctgggcc gagagttcga
     6721 aggtgatgcg tgctgcggac cacttgtgtt cccggcgcag ccgctcgatt tgctccacta
     6781 ccgcgccggc gtggctgtcg gttggtggcg aggcgcggag gaccggtcgt gcaggccaag
     6841 ttcaccgtag cggcggaacc ggtttaccca tttcgacgcg cacgctcttg agatccccat
     6901 ctccgcggcc acgtgggcga tcgggcgcga cttacagcgt tcgacgaggc ggcgccggcc
     6961 ttcaacagac agcggggcgt tgcggtgaag cgacggtctc ttcccggtca tcgggtgtgc
     7021 cgtgtgggtg cagagacagc aggaaggtga accgctacca gcggcaggaa gcagcctacg
     7081 aggggcccca tgcacagtgc gataagcaca gtgccgaccc cgacggttcc acccagaagc
     7141 cagccgacgc aggcaacagc gacttcgatg ccggtgcgca caagggcgac gggcaggtgg
     7201 gtgagccgaa cgagtccggt catgatgccg tcgcgtggtc ccgacccaaa ctgcgcgccg
     7261 aggtagagcg cgtcaaagaa tgccagagcg acaaggccga gggcgagata tccgatctcg
     7321 gcgagtggcc cctgtgggtt ggggagcaca gtcgcggtgg catctgcggc gaagccgacg
     7381 atcgcgacgt tgaggagcgt gccaagcccg ggcagttctc gcagggggat ccatgcaata
     7441 agcacaagca gcgagatcag gtttgtcgcc caaccgaacg agatatcgag ggatttggcg
     7501 gtgccttctg tgagcacgtt ccagctggct gcgccaagcc cggactggac gagcagcatg
     7561 acggaggccc cgtatcccat caagccgagc aggagctggg ggatccgacg tgcctttccg
     7621 gccgcccgga cctgggcgaa tgcgttcatg tgcggtagta cgggtgggtc gtgacgagcc
     7681 gggacggagg tgtgcgtcgt ggaagcggga ggtgccatat ggcgagtctc ttggccatct
     7741 ggtcctggat tccatagcca gattggctag gctggttcgg tgaaaatcag ctcgcacgcg
     7801 gtagcgggga tgttggggac ctggcaggag gggccggggc cggcgcatca acgtctctcc
     7861 gacaggctgc gtctgctcat cctggatgga cgcctctttc ttggtgcggc cctgccgagt
     7921 gagcgtgacc tggctgtcgc gctcggcacc agcaggacca ccgtcggtac cgcgttccgc
     7981 acgctggtcg agcacggata cctcgccaca caggcgcgta ccagggcgac ggtacgactg
     8041 cctgatgaca ccactcccga gcacttggtc ggcacggacg cagagaccat cgacctgtct
     8101 tttgccgcgc cggctgcgcc cgtagaaatc ctccacgccg cgttcgcgac ggctctcgaa
     8161 cagctgccac gtcatttcga gcggcacggc tacgaccgat acggcaccgc tgagctgcgc
     8221 gaagcagtcg cccgatggta tcagcggaga ggactgccca cccggcccga tcacatcctg
     8281 atcaccaacg gcgcgcagca cgctctagcg cttctgacgc gcgtactcct gtcgccacgc
     8341 gacaaagtcc tcatcgacca tccgacctac ccgcacgcga tcacgacgtt cactcaagcg
     8401 cgcgcccgtc ttctacccgt cgccgtgacg tcttccggct gggacaccga gcaactccaa
     8461 gcagcagggc aagccgcgaa tctggcctac ctgatacctg actttcacaa cccgaccggg
     8521 atgtgcatgc ccacgagcgt gcgccaacag ctcaggctcg cgtgtcccac tgtcgtcgac
     8581 gagacgatga ccgatctggc tctggacgtt ccgagccccg aacccctcgc gctgcacatg
     8641 ccgacggcca tcagcatcgg ctccgtgtcc aagagcgtct ggggcggcct acgcacaggc
     8701 tggattcgcg cgctgccctc tctcctggaa cgtgtcgaac aagcccgtcc caccacagac
     8761 ctcggcaccc ccgtcgtaga acagctcgcc acagccgtcc tcctgaacga gcaccagacc
     8821 cagcggcccg acacgctcca gcaactcaga tcgcaacgtg acgccctgtg gcaagcactc
     8881 accgaacacc taccgaacgt ccacgccccg cagccagctg gcggcgtgac gctatgggca
     8941 gccttccccg ggcccgtcag ctcgcggctg gcagccatgg cgcctgacca cggagtgacc
     9001 atcgcggccg gcccacgatt cgggatcgga ggcgcgttcg aacgcaacat ccgactgccg
     9061 tacacgctcc cttcgagtca actagcccag gcaatccgca gactcgcgca ggcagcacag
     9121 gcactcgcac aaggcgctac cggtactcac accctcgcgc ccatcgcatg agcgtcaaca
     9181 acgtcatgac gcgcaacacc tagatgccta tgccgagcgg cagcgacggc ccatgaaccg
     9241 caagggcgag gccgacgtcc cggtgcaggc cggtcacgtg ggcgagccgt ccttgaacgg
     9301 cggcttcgtc gactacgacc tcgccccgcg cgaatacgag ttgtccctca cccagaccgt
     9361 gctgcgcgta cacacccggg tcgcggatct ctacaacgag ccgatgaacc agaccgagca
     9421 gcaactccgc ctgaccatcg aggagatccg cgagcgccag gagtgggagc tcctcaacaa
     9481 ccgcgaattc gggctgctgc acaacgccga ctacggccag cgcatcagca cgttcaccgg
     9541 cccgcccact ccggacgatc tcgacgagct gctctgcatg cgccgcaaga cccggctctt
     9601 cctcgcccac ccgaaggcca tcgcggcctt cttccggcag tgcaaccggc gcggcctggt
     9661 gcccggcacc gcgaacatcg acgggcacga gctgcccgcc ggcgcggcgt cccgttgctc
     9721 ccctgcggca agatcccggt caccccgcag cacaccagca gcatcatcgc gctgcgcacc
     9781 ggggaggccg accaaggcgt catcggcctc tatcagaccg gcatcccgga ggagtaccag
     9841 cccggtctga acgtgcggtt catgggcatc gacaccgccg cgatcatccg ctacctcgtc
     9901 accgcccact tctcgctggc catcctcgtc ccggacgcgg cggggatcct ggaaaacgta
     9961 cagatcggcc ggaccgccga atgacgggat ggagcaccga atgagcgcgt caccgcttcc
    10021 cggtacctcg ttcgcgccgc cgggaccgca cgacatcgcc ggcaccgtgc gggcccggcg
    10081 tggcggggcg atccccgggc tcaggtatcg gccggcggtc cccgccgatc ccgcgaaggt
    10141 cgcggagacc gatcgcaggc tggaggcatg ggcccgccgg ctcgacgtgt tccccgaggc
    10201 gtggttcggg gatttcgcgg ggttccagtt cggccgggcc gtggtgctcc agcacccggg
    10261 tgccgcggac gtggagcgcc tcaccgtcgc cggcaaactg ctgctcgccg agaacatcgt
    10321 cgacgactgc tactgcgagg accggggtgg ttcaccgcgc ggtctcggcg gccggctgat
    10381 cacggcccag tccgcgatcg acccctacca cggcactccc gaggcggagg agcagtggcg
    10441 gcacggcatg caggccgacg ggccgctgcg ctcgtaccac tgggccgtca aggactacgc
    10501 caccctcgcc acgcccagcc agacggaccg cctcgtccac gacatcgccc ggctgcacct
    10561 ggggtacctc gccgaggcgg cctgggcgga gacacgccat gtgccgcggg tgtgggagta
    10621 cctggtgatg cggcagttca acaacttccg tccctgtctg tccatcgtcg aggtggcatg
    10681 ccaccaacac ccaccgctac cacctgccga actactggta accactactg acagtacgtc
    10741 aaatgcactg cgaggagcca ctgttgacca ccgcccccga cgccgtcacg gcagcaccgg
    10801 taccgaccca gtccacgtac cagtcccgcg tcgcggacta ctggaacgcc gaggagaacc
    10861 cggtcaacct cgaactcggc aagatcgacg atctgtacca ccaccactac ggggtcgggg
    10921 ccgtcgacta ctccgtgctc gacgagcccg acccctcgcg gcgccacgag aggatcaccg
    10981 ccgagctgca ccgactggaa cacgcccagg ccgaactgct ggccggccac ctcagccccc
    11041 tctcccccgc cgaccgcgtc ttcgacgccg gctgcggtcg cggcggcggc agcgtcgtgg
    11101 cgcacctgcg gtacggctgc cacgccgacg gcgtcacgat ctccgccaag caggccgact
    11161 tcgccaacga acaggcccgc aagcgggaca tcggcgacaa ggtgcgctac caccaccgca
    11221 acatgctcga cacgggcctg ccgaccgggg cgttcgcggc ctcgtggaac aacgaatcca
    11281 ccatgtacgt cgagctggag ctgctgttcg ccgaacatgc caggctgctg cgtcgcggcg
    11341 gacgctgtgc ggtgatcatc gggtgctaca acgacaccta cgggagggcc tcacgcgaag
    11401 tgtccctcat caacgcccac tacatctgcg acatccatcc acggtcggca tacttccggg
    11461 ccatggcccg caaccggctg gtccccgtgc acgtcgagga tctcaccgga gccgcgctgt
    11521 cctactggga gctgcgcaag cggtccgacc ggctggccac cggcatcgag gactcgttcc
    11581 ggaccgcgta caagaacggc agcttccagt acctgctgat cgtggccgac cgcgtctgag
    11641 gccacagaac gccgcccctg tcccgccgcc gcggcacgac ggcggaccag gtgtacgtcc
    11701 cccgggggag ggccactgtc cgacagatgt cacggagtgg ccaacagcga ctccaaggcc
    11761 accgcggtat ccggatgacg gccgatcagt tgcccgcccg ccgggccggg atcggctgtc
    11821 tgccacgtac cgtcgcagcc cagcaggctc gccaccgcgt cgcacgtcgc ggggtgggcg
    11881 gcgagcagcg cgacgttgcg gccctcgccc gcgcgcccgc ccgggcgcgc ggtgtcgggc
    11941 aacggctggg cccgccacgg cggcacccac gcgtccagct cccccagccg gccggggaag
    12001 atccgcccgg cttcacggat caggagcggg gcgagctccg cgccgttgga gcgcagggtg
    12061 ctgatgaggg tgggcagcca cggcagcagc accgggtccg gcaggcgtcc gaacgcgttc
    12121 gacactgcct ccacgacgag gtcggccagc cccggcaccg gttccagcgc gtgcacgaat
    12181 ccgctgaggt aacgcggata ggcaggcacc accatggggt tgtccagcag ttcgtcgcag
    12241 cgtgtgcgaa ggtccgcgcg ggagagatgt ccgagctgta cctgagccgc ccacagcagc
    12301 gccaccttcg acggctcctg cggatgcgac tgcgcgacgg acagctccag ctgggttcgg
    12361 tcgcagccca gcgacagcgc caggctctcc atgccgaaca ggaatcccag catcgccgcg
    12421 acctggcgga cggtggcgtc gtcgtcggtg aacgccgtcg gcagcagggt gcagtagtgc
    12481 gcgtatccgg tcttgacgaa ggactcgatc cacggtggca gcaccggctc gctggtgcgg
    12541 tagtacgcca gcagccgccg cacccggcgc agcacctccg gtgcgccgtc gacgctgcgt
    12601 tcggccgaca gcacctcgag ggcgcgggtg cccagctcgt cggtgaggcg gcggctgcgc
    12661 aggtgcagcg tcgcgtcctc gatggcctcc aggacggtcg ccgtggtggc gtgcggcccg
    12721 tacgccgtgc ggcgcaggcg ctgctccagg acctgctcga tgctgacacc ctcgtagccg
    12781 agctcgatga gcgcgcgctg gtgggtgccc agcgccaggt cccacgactc ctggatcggc
    12841 cgctcgccga gccgccgctc acccatgatg ggccgggccg tgccctgcgg catcaggtac
    12901 cgcagcatcc acagcacgtc ggagcactgc tccagttgcg gctgggagga tatgtccagc
    12961 aacgcccgct ggacgccgcg ctgctgcaac ttcaggttca gcggcgcgag ccggtcgtgc
    13021 acgtcgcggg ccagtggtgg cagcgcgtcg taaccgacct ggccgatccg gtcgccgccc
    13081 atcatgatgt cgacgaggcg gcgcacatcg cgccggcccg gcacggtgtc cttctcgatg
    13141 caggtgaccg ccgcgtcctg gaagtcgtac ggcgtgggtc tggcccgatc gcgcatcccg
    13201 gccagcagga tggacgtctc gaacaccgcg atggcgtcag cggtggaggc gagatagccg
    13261 ttgcggcgcg cggcgcgcac gatctccacc gaccagccga gcagttcggt ctcgtcgagc
    13321 cggtccagga cgggcggtcg ccgcaggaag ccggtcagct tgtccgagtt cgcggccgcc
    13381 ggcacggggg cggccgcgac cgcggtcttc ttggccttcg acgtcttcgc gcccgcctgt
    13441 cccgccaggc ggaagggctc cacgcgcgtg cgcctgacgt tcttcgccca caccgtcgcg
    13501 gcgatcgaca ccgagccgga ggcgaggccg aactgcgtct cgatcgccgc gtggctggac
    13561 ggaatgaggc cgtgctgcca cctggtggca ctgcgcggac cgatctcgaa ggtgtcggtg
    13621 ccgtggacgc cgaactccgc gacgcgactg gccgcgtgga aggcaccgca gacgtaaagg
    13681 cagtccgcgg catcggtgcc ggtcgcggcc aggtgttcgc gcatcctggt ccacatgtag
    13741 cgttcgcggt cctcgtccac gcgcacccgg tgggggtcgc cgggggcaag gcgtctgaag
    13801 aggctgccga tcaggagcat gacctggcga taggtgtcgt gatcgctgtc gccgaggggc
    13861 agttcgacgt actggtgcca ccactccgac cagtgccgca ccctgccgtg gtgcagcagg
    13921 tgttcctcca gttcggcgaa gcgcggccgc aggtcgccga tctccacgcc gaccgcgtcg
    13981 ccgtgcagtg cggcctcctc ctcgacgggc ggtgcgtccg acgcccctgg atcggcgccg
    14041 gcctcggcgg agtgcgtccc gcgcgagtcc cactggaaga catggtccga ggaacggtcg
    14101 acgaggacca gttcgacgcc cggcgtgtcc agtgcgtagg cgattgcctg gtactcggcc
    14161 gaggcctcgg tgatcggtgc gaccaccgac agcggggacc agtcggccgg gaagccgtcg
    14221 acctcggtcg cgaacgcctg caccgccacc ggcagtcggc agttgcgcag ttcggtcagc
    14281 aggggcgcca tgtcctcgca caactccagg tacacgacct tcggccgctt ctcccgcagg
    14341 cggcgtgcca tcgcgagcgc cgaggcgggc gagtggtggc agacggggaa gatctccagt
    14401 ggctcgcgca ccgcgcggtc gacgtcgtcg acgatgccga ggaggatgcc ctccagggcg
    14461 tcgggcccgt cggagaacgt cgcggcggcc tcctgcaact gtccgcgcag ctcttcgaag
    14521 gtctgcccgt gcgtgccgct catgagaggg tggcgatcgc gtcgcggccg ccctccagga
    14581 actccggcca ggatccgccc tcttccttgc cgcgcggctc gacgacgccg tgcaggtact
    14641 tgttgaggat ggccaggtcc tcgggctcgc gccgggccag tgacccgacg agcgaggagg
    14701 ccagcgtgcg ggcggtcagg gcgcgctcgc cgaagaagtt gctgtgcagg atcgcgtcct
    14761 cgaggacgcc gatctgttcg gcggtggaca gcgcggactc cagcttctcg tcgtcgctgc
    14821 cggccgcggc cgcggaggca cgcaggtcgg cgaagctctg caacagcacg tcgagcagcg
    14881 tcggcggcac gtccagctcg atctggtggc gccggagcag ttcctcggtg cggaagcgga
    14941 cgatctccgc ctcgctcttc ctgttcgtca tcaccgggat gcgtacgaag ttgaagcggc
    15001 gcttgagtgc cgaggacagg tcattgacgc cccggtcacg gctgttggcc gtggcgatga
    15061 tcgagaagcc gggctgggcg aagacgacgc tgtcgctgtc cagttcggga accgagacgt
    15121 atttctcgga caggatcgag atcagcgcgt cctgaacgtc actggtggaa cgggtgagtt
    15181 cctcgaaccg gccgatcgcg ccggtctcca tcgccgtcat gatcggcgag gggatcatcg
    15241 actcccgcga ctggcccttg gcgatgacca tggacacgtt ccaggagtat ttgatgtgat
    15301 cctcggtggt gccggccgtg ccctgcacga ccagcgtgga gttgcggcag atcgcggcgg
    15361 acaacagctc ggccagccag ctcttgccgg tgccggggtc gccgatgagc agcagtccac
    15421 ggtcggaggc cagcgtgacg atggagcgct cgacgaaact gcggtcgccg aaccacttct
    15481 gcgagatctc ccgctccagg ccgtcggagc gctcggagcc caggatgaac aggcggacca
    15541 tcttcgggga caggcgccag gagaagggct tggggttgtc gtcgatggac tccagccagt
    15601 ccagttcctc ggcgtacttg atctcggcgg gggcgcgcaa caggtcggac atcacagggc
    15661 ctttctaagc gaggaacgtc ttgagttcgt ggacgagctt gcggatgtgg ccggagacca
    15721 ccggcgtgcc aagggccttg aagcgctccc ggaaccaggg gttgacctcc tggcgaccgg
    15781 agctggtcac cgagccgacc gggatgaact tcaccccgga gcggtggacc gcctcgatgc
    15841 cttcgaacag cggctgggag cggtcgaact catagaagtc cgagatccac accatcacgg
    15901 tgctccgcgg ttcggtgatc ttcgggcggg ccatggccat ggcgacgggt ccgtcgttgc
    15961 cgcccccgag gttggtgcgc agcagcatct cgaacgggtc gctcacccaa ggggtcaggt
    16021 cgatggcacg ggtgtcgtac gcgatcaggt ggacgtccac cttcggcagc ccggcgaaga
    16081 tcgacgccag gatggtgcag ttcaccatcg agtcgaccat cgagcccgac tggtccacga
    16141 cgacgatcag ccgttggggc gtcgtcttgc gggcggtgtg ccggtagtag aggcggtcga
    16201 cgtacagccg ctcctcctcc gggctccagt tggtgaggtt cttccagatc gtgcgatcga
    16261 ggtccaggtt gcggaaggtc cgcttgggtg ggacggagcg gtccagcgcg ccggccgtgg
    16321 cctgcgccac ctgggtgcgc agcacctcgg ccacctcgtc gacgaagcgg cggatcagag
    16381 ccttggcatt ggccagcgcg acgccggaca gattgttctt gtcgcgcagc agctgttcga
    16441 tcagcgacat gctcggggtc agctgtgcgg cgagggtggg atcggcgagg acctcacgca
    16501 agtgcatccg cttcacgaga tcggcctcga tggcaccgag ttccgggccg atcgcgggaa
    16561 tcagacggcc gaggtcgggc gtcgcaccgc gaccgccggt gccggccgga ccggcgcctc
    16621 gccccgcgcg ccctcctccc gggcgtcccc cgcgcagttc gcccggccgg cagccgagcg
    16681 ctcgctccag ccaccccgcg tcggactgcc agcgcgacag ctgtccggcg gtgacggtgc
    16741 cggatccggc ggcgaagacg ttgagcagca ccttcgacac cagggccgca cgccgtactt
    16801 cggcggcccg gtcgcgtccg tcgtcgtcgg gctcgggctc gggcaccatc agaccgtcga
    16861 attcggaggc cagctccggg tggcgctgca cgatcgagtc gacggaggtc cccgggtcca
    16921 acagcccgga cggcagaccg atgtcctcga cgacagcgag gctcgccgac tccagcgtcg
    16981 cctgttcttc gtggtcgaag agacgggcga ggagccgcca gtagagaacc tggcgacggt
    17041 tctcgtccga gtccgcctcc gcgttctgct cgggcgtgtg ttcggtcgtc cgctcggtca
    17101 tttcctcagc agccttccgg cgcgctcacg caacaccgcc acagcctcgg tggcggcctt
    17161 ctcggccttg gcgcccgtct tgtcggccgt gccgccggcc catgctccgg cgtggaccgc
    17221 gacagccttc ttccgcacgg tcgtctcgac ggcgagcggt tggacgctga acgccccggt
    17281 gtcccagcgc agcaggccga tgcacgcgtt cgacagcgcg acggcctcgg gggtcagcgg
    17341 gccggtggtc gggacccggt cggcctcgac ggcgagtccg tgtccgtgtc cgtgtccggc
    17401 cgtgttgaac gtcagtacgt cgccgtcctt gtggacggcg tagccctcca ggaacaccgg
    17461 tacggcgatg cccgccggat gccggtgaag cggcgcggtg tgtgcggcgg tcgcggtggg
    17521 caggacgacg cgggcggtgg cgaaggggtc ggcgggctca ccggggcgcc cttgttcatc
    17581 actccagatc aggtcgcctt cggcggtgat cggcatggcg tggagctcca tcgaacggcc
    17641 ttcgcctgcg gcggccagga gcgacatgtg cgggcggagc agctgccaga caccggctcc
    17701 gacgaccgtg tccggcttcg gcaccgagac actggcgcgt accaggcggg gcgcgctgcc
    17761 gtccgcgggc tcgaacacgg cgtggacctg ggcctgcgcg gcggtcgcgt gttcgtgcac
    17821 gtcgacaccg aggggcagca ggcggccggt ggcgggagcg gtcgtgggcg cgtcggcggc
    17881 gccgggcacc gtcaggagca tcgcacgcga ccacacatct ccccagcggc gtaccggcat
    17941 tcgcttgagg gccgccccgg ggcaggaggc ggcgagttcg gcggcgaagc cgtcgaggag
    18001 cgtcgccagg cggcgcaggg aggggtccgg gagcatcgac gagacgacct gcgccgatgc
    18061 cgacaccacc tcgtgatcga tgccctgcca tccggcgcgc gccagatcgc agagccagga
    18121 gcgggcggcg gccagcaggt tcaccatgtg ccgctcgccg ggcgtcgagg ccgtcgcctc
    18181 accgcgggtg cgaccgatca cctcgtcgac gcgggtcatg agggcgtcgt ggacggagcc
    18241 gagcagtgcc gtgcgggcgg cggccagggc gacgaagtgg tcctcgctcg cggctccggc
    18301 cgccgccttg tcggcggcct ccgcgaccct ggaggccagc ggtgtccccg cgacggcgca
    18361 ggcgagttgg ttcaggtcgg cggcctgggc gggctggggc cggagcaggc cgccgacgag
    18421 cgtccggtcg aagccatcga ccgcggccag ggcttcgtcg agcccggcca tgggttcggt
    18481 gagcaggtcg gtgcgcatca cgccaccgcc ctggtcggcg ggaaccactg catctcgggc
    18541 aacggcgcgg tggtcggggc gagttccagg taggccaggt ggcgcaggaa ccggctgaag
    18601 acccaagcgg cggccttggc gtccccctgt ggcgggttgg ttccgctcat ctccgcggcg
    18661 atgccctgtg cgctccgctc ctcgtccgcg atgtccacac gcaggtagcg gacgacgcgc
    18721 tcgacgccgt actgcagcac cgcctcgttg atcagggcct tgatgtggtt gcagaacgag
    18781 ccccgagcgc cgccgcaggg acggttgttg ttggtgctgc acgcgaacgc gtagctgccg
    18841 gccgcgaccg atgagacgta gacccgctcg atgtccgatc cgctggacac cacgccttgc
    18901 aggcgtccgt cggcaagttc gacgaacggg accttcgcga gcttgcgcgg tcgcgcgggc
    18961 ggtatcacgc gcgccatgct ggacttctcc caatccgaca acgcaccatc tcctttgcac
    19021 caaggggctc tcgcgccaga gcggcgagac acggctgaac atagtggcga ccactgacaa
    19081 cgccgatcac aggcggagtt cacccccgtc gagcgtgctg tgcgacaggg gtacgaaccg
    19141 gccgccccga cgaccgggag cccggacccc ggtccggacg ccgcgcccgc gacgccaagc
    19201 tccgcacccc gataatccgt tgccgcccac gctcgcccga gcgatcatcg cgggatgccg
    19261 accactcccc cggacggacg ctccgggatc gacgctgccc tggtgagccg tctgatcgcg
    19321 gcgcagttcc ctcagtggag cggcctgccg gtgaccccgg tggacatcga cggctgggac
    19381 aaccgcacct atcgcctggg cgacgacatg acggcccgtc tgcccaccgc cgccggctac
    19441 gttccagcgg tcaccaagga acacgagtgg cttcccaggc tcgcaccatc gctgccggtc
    19501 gccatcccgc cgatcctggc gatgggcgtc ccgggtgagg gatatccgtt cccgtggtcc
    19561 gtacgcggct ggctccccgg tgagcgagcc gatcgagggc gcatcgacga cctgtcgcag
    19621 ttcgcggtct cggtagccga gttcgtcctc gcgctccagc gctgcgacac caccggcggc
    19681 ccgctcgccg gggaacacag ctggtaccgg ggcgcgtcac cggcccatta cgacgacgag
    19741 acccgccgtt gcctggccgc cctcgaggga cgtgtcgaca ctgaccgtgc ggccaccgtc
    19801 tggggcgccg ccctcgccgc cccgtgggat gggaaccccg tgtggttcca cggcgacgtc
    19861 ggcgcgggca acctcctggt cgcagacggg aaactcgcgg ctgtcatcga cttcggcaca
    19921 tccggtgtcg gcgatccggc ctgcgacctg gtgatcgcat gggggatgtt ctccggcgac
    19981 agtcgggacg cgttccgccg tgctgtcggc caagacgagg gcacctgggc acgggctcgc
    20041 gggtgggctc tctggaaaag cctgctgacc ctggccgagt gcatcgacac cgatccggaa
    20101 caggccgccg tcaaccgacg tctgatcggt cacgtgctcg aggatcaccg ccgcttcgcc
    20161 cagccaagcg tggcgtagcc gatccgggcc tgctttcgcg cgtaggtccg gtgctgggcg
    20221 cgggcgacac gatgaccttc gagacggtgg cccagagcac ccgggacgcc cccaccggtg
    20281 tggacggccg cgttgctccg tacgagtggt gcatcccctg acacagtcgt agcgtcagta
    20341 cagagacgat cgctggcgac ggaacggcac accgtcctgc gtcagcccca caatccagac
    20401 ttcgccaggc gagcggacca gaggtatgcg cgcggggcca tgggtggcgg agacaggcgg
    20461 ccgggagcgg acatgcggac acacacagtg aaaacgttgg ttacgctctg tgcggctgta
    20521 tcgctcgcgg cagccacggg atcgtcctcc gctgccccgc cgaccgcgcg ggccgtgaaa
    20581 cagcagcccg aacgcaccgt gcttgtcgac tgtttctgga aaccgaacgt acgccccacc
    20641 gacttcatcc tcgcctgcgg tgacggcaac agccgtct
//
