LOCUS       NC_003155              22389 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 290465
            Orig. end                         :: 312854
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22389
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22389
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22389
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12389](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12389)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(173..186)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.62"
                     /tool="antismash"
     misc_feature    1260..1274
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(1726..1740)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.63"
                     /tool="antismash"
     misc_feature    2239..2254
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.99"
                     /tool="antismash"
     gene            complement(2503..>3270)
                     /db_xref="GeneID:41537432"
                     /locus_tag="SAVERM_RS01700"
                     /old_locus_tag="SAV_251"
                     /old_locus_tag="SAVERM_251"
                     /pseudo=""
     CDS             complement(2503..>3270)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357491.1"
                     /locus_tag="SAVERM_RS01700"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_251"
                     /old_locus_tag="SAVERM_251"
                     /product="MMPL family transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="VVSSLTPKSDAAQSLVGDVRALTPPPGTHPLVGGIDAELVDAKHS
                     ISGQIPLAIGLVVVTTFVLLFLFTGSVVQPLRALALNAITLVATLGIMTRIFQDGHLSS
                     LLGFTAQPMEMSMTVLMFCIVFGLSMDYEVFVTSRIKELHAPGEDTESAVTNGLGHTGR
                     IVTAAACLLAVSFFAFGTAKLSFMQMFGLGSGLAILIDAVAIRGVLVPAAMRLLGDSAW
                     YAPGFLRRFHGRFGLSESAPESAAEPEPAVSRG"
     gene            3426..4145
                     /db_xref="GeneID:41537433"
                     /locus_tag="SAVERM_RS01705"
                     /old_locus_tag="SAV_252"
                     /old_locus_tag="SAVERM_252"
     CDS             3426..4145
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537433"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="SAVERM_RS01705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_252"
                     /old_locus_tag="SAVERM_252"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_202497609.1"
                     /transl_table=11
                     /translation="MAGVDLELKRGEVVALVGENGSGKTTLAHLLTGLYLPDHGTVEWD
                     QVDLATADPQSVWKSVAMVPQDYTRWPLTCRENITLGMPSDEGDAAVLRAAEEAGAMAV
                     VAHLPDGLDTSLARSWWGGHDLSGGQWQRIALARAFHKDAPVLILDEPTSALDARIEHQ
                     VFSRLRELSAGRTALFITHRLANARVADKVIVLEKGAVAESGTYDELLRIDGLFAELHR
                     MQEGAERDIPTPRTTRI"
     gene            4447..4779
                     /db_xref="GeneID:41537434"
                     /locus_tag="SAVERM_RS01710"
                     /old_locus_tag="SAV_253"
                     /old_locus_tag="SAVERM_253"
     CDS             4447..4779
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537434"
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="SAVERM_RS01710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_253"
                     /old_locus_tag="SAVERM_253"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_010981689.1"
                     /transl_table=11
                     /translation="MPSGKLDQGDPLPAGAARELFEETGITVAPGHLRLVHVVHHRQDD
                     EVERIGFFFEATDWQGEPVNREPDKCLALTWFTVHELPDGIIEYPQAGLRGYLDETGPL
                     VAHNWE"
     gene            5336..>6073
                     /db_xref="GeneID:41537435"
                     /locus_tag="SAVERM_RS01715"
                     /old_locus_tag="SAV_254"
                     /old_locus_tag="SAVERM_254"
                     /pseudo=""
     CDS             5336..>6073
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537435"
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033580.1"
                     /locus_tag="SAVERM_RS01715"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_254"
                     /old_locus_tag="SAVERM_254"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDAEWAVVRDAMPVPGWLEGRGGQPESYCHRQMVDAVRYLVAGG
                     ITWRAMPADFPAWDRVYAFFRRWRDKGLTAEFHDRLRDRVRQAAGRDLEPTAGIIDAQS
                     VKAAASVPAVTRGFDGGKKVNGRKRHIVVDTLGLLLAVMVTAASVTDRDAGQTLLARLR
                     ERHWRVTRVWADGGYTGRLVDFARDAWRIALTVVRRSDDTSGFTVLPKRWLVERTFAWL
                     MHSRRLARDYETRTDTSEAVIKWA"
     gene            complement(6008..6358)
                     /db_xref="GeneID:41544671"
                     /locus_tag="SAVERM_RS39195"
     CDS             complement(6008..6358)
                     /codon_start=1
                     /db_xref="GeneID:41544671"
                     /inference="COORDINATES: protein motif:HMM:NF025180.4"
                     /locus_tag="SAVERM_RS39195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase family protein"
                     /protein_id="WP_338059012.1"
                     /transl_table=11
                     /translation="MAACAVLAGAKSLAAIAEWAADAPPNVLARLGGPCREPDRGPVAP
                     AEATVRRVLQRIDGDALDTAVGSWLAGRERAAGQEENAARAPAAPHDCAHRPLDHCLRG
                     VGARLVVAGQPA"
     gene            6622..7971
                     /db_xref="GeneID:41537436"
                     /locus_tag="SAVERM_RS01720"
                     /old_locus_tag="SAV_255"
                     /old_locus_tag="SAVERM_255"
     CDS             6622..7971
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127610.1"
                     /locus_tag="SAVERM_RS01720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_255"
                     /old_locus_tag="SAVERM_255"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_237528690.1"
                     /transl_table=11
                     /translation="MLATAGSTVAEAGTPSGPAPGAAVRAAEPATPDRPSYDVKLRADG
                     DGSHWAGRQTVSFRNASSRPLREVYIRLWGNGEDGCGTSGRPSPVRVSHVRGGTPGRPG
                     VKCTALRIALPRPLARGERTAVSFDVALTVPARNNRFGREGAFRFLGNALPVLAVHDAR
                     GWHLDPYVSYGESFYTLASDFRVRLDHPSALKVPATGSTWTRPGGTGRTVTHSVAKRVR
                     DFAWAAGPFRTATQTSPDGVRVKSYWSPNTPAAGVRLNRKDGVAAIDRFGREFGRYPYG
                     EIDLVMTPGFAGGMEYPGLVILGTEEEGGATVHEIAHQWWYGVVGNDEYNSPWLDESFA
                     QYANARYYRWDGFECSPDDSWPSATAALTNSMAYWSTHRGEYFQVVYGIGPCVLADLEH
                     VLGAGTMARLIKKYAHDHWYGVSTTVDFKKAAQSMTHRDLGPFWRKHRIR"
     gene            8199..9407
                     /db_xref="GeneID:41537437"
                     /locus_tag="SAVERM_RS01725"
                     /old_locus_tag="SAV_256"
                     /old_locus_tag="SAVERM_256"
     CDS             8199..9407
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004993514.1"
                     /locus_tag="SAVERM_RS01725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_256"
                     /old_locus_tag="SAVERM_256"
                     /product="ISAs1 family transposase"
                     /protein_id="WP_010981692.1"
                     /transl_table=11
                     /translation="MPARSSSLIARSLGQLAGTAPTVPDDLPGLLTCLAQVPDPRRDQG
                     RRHPLAFVLSLAACAVLAGAKSLAAIAEWAADAPPNVLARLGGPCREPDRGPVAPAEAT
                     VRRVLQRIDGDALDTAVGSWLAGRERAAGQEENDSDRRPLPSLAVDGKTVRGARRTDGT
                     QVHLLAAMTGTGLVTAQREVDATTNEITVFQPLLAPLNLHGTVVTFDALHSQTAHARFL
                     VEDKHAHYIALIKGNQPTLHQWLKALPWREVPLLDKTRATAHGRDEIRRIKAAAVAGIA
                     FPHAVQAVQIERRRRIVTTGKVTLERIYGVTDLTAEQADATEIARRVRGHWGIENKIHH
                     VRDTTYAEDASRVRTGTAPRAMASLRNLAIGALRLANQTNIAAGLRHHTRDANRPLITL
                     GIM"
     gene            complement(<9660..10004)
                     /db_xref="GeneID:91294749"
                     /locus_tag="SAVERM_RS44160"
                     /pseudo=""
     CDS             complement(<9660..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91294749"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056405.1"
                     /locus_tag="SAVERM_RS44160"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPADPTSPPGTIVTRGLRRTYGDVEAVQGLDLTVAQGELFAFLG
                     PNGAGKSTTIGMLCTTLRPTTGHAQVAGADITRSPHDVRRQIGVVFQESTTDDDLTAQE
                     NLRLYADLYGI"
     gene            complement(10001..10420)
                     /db_xref="GeneID:41537439"
                     /locus_tag="SAVERM_RS01735"
                     /old_locus_tag="SAVERM_7586"
     CDS             complement(10001..10420)
                     /codon_start=1
                     /db_xref="GeneID:41537439"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056406.1"
                     /locus_tag="SAVERM_RS01735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAVERM_7586"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_037652994.1"
                     /sec_met_domain="PF13471 (E-value: 1.6e-26, bitscore: 91.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGQLTLEPSTAIPWNQRPAALVTVTAARLLARVSPRRLRQVLEL
                     ASRGARPADLPQALQARNAVVSVSVTIAGPRCLERSIATALLCRLGGTWPQWCTGVTTR
                     PFAAHAWVAVDGDAVGEDPDAVTDFHLVMSVPARR"
     gene            complement(10417..10680)
                     /db_xref="GeneID:41537440"
                     /locus_tag="SAVERM_RS01740"
                     /old_locus_tag="SAV_258"
                     /old_locus_tag="SAVERM_258"
     CDS             complement(10417..10680)
                     /codon_start=1
                     /db_xref="GeneID:41537440"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056407.1"
                     /locus_tag="SAVERM_RS01740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_258"
                     /old_locus_tag="SAVERM_258"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_010981694.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 6.6e-09,
                     bitscore: 34.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-22,
                     bitscore: 78.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-13, bitscore: 49.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNFALAPEVSVTDTEHGTVLLDERTGRYWLLNGTGALALRALLD
                     GTSPQGVVASLCQRFPDAGTAQVEQDVDNLLHALRTAKVAAS"
     aSDomain        complement(10426..10677)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SAVERM_RS01740_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="5.40E-25"
                     /identifier="RREFam002.1"
                     /label="SAVERM_RS01740"
                     /locus_tag="SAVERM_RS01740"
                     /protein_end="85"
                     /protein_start="1"
                     /score="78.2"
                     /tool="antismash"
                     /translation="MNFALAPEVSVTDTEHGTVLLDERTGRYWLLNGTGALALRALLDG
                     TSPQGVVASLCQRFPDAGTAQVEQDVDNLLHALRTAKVA"
     aSDomain        complement(10531..10680)
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SAVERM_RS01740_Lasso_Fused_RRE.1"
                     /evalue="2.40E-11"
                     /identifier="RREFam003.1"
                     /label="SAVERM_RS01740"
                     /locus_tag="SAVERM_RS01740"
                     /protein_end="50"
                     /protein_start="0"
                     /score="34.6"
                     /tool="antismash"
                     /translation="MMNFALAPEVSVTDTEHGTVLLDERTGRYWLLNGTGALALRALLD
                     GTSPQ"
     gene            complement(10677..12389)
                     /db_xref="GeneID:41537441"
                     /locus_tag="SAVERM_RS01745"
                     /old_locus_tag="SAV_259"
                     /old_locus_tag="SAVERM_259"
     CDS             complement(10677..12389)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537441"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="SAVERM_RS01745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_259"
                     /old_locus_tag="SAVERM_259"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_197586351.1"
                     /sec_met_domain="Asn_synthase (E-value: 3e-48, bitscore:
                     164.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTAVGPHRVALLGRTTADADVLTRRLRDVRSVRDLDGLAATAAG
                     SFHLVASVNGEVRVQGTLSAACQIYYATVAGVTLAADRPQALADRIGADIDEDQVALAL
                     LSPFGPPWPLSERSLWRGVCSPPTGHCLEIGRDGTGRTRQWWTAPDPDRPLGNGDMIRQ
                     ALAEAVATCTAGQEVVSADLSGGLDSTSLCFLADADRHDAHLVTVHYQALGRSSDDRYW
                     ARQAEAALPGARHLLVGPGQAPDWYAPLAHAVHDREGPLTFVRSRATTEHLARLAAAHG
                     SRRHLQGIGGDELFHPSPMALHALVRRHPLAALPHLRALRSMRRWPLTTTARTLASAPS
                     YTQWLAACSNFPADRHDWGAGADWEPLPKLPPWATPHAAATVRRQLLAALAATPQPLAT
                     LPVQHEMIRLTRINGNATRRNSHIGAHTGVTFHAPFTDDRVLEAILAVRLEDRVALGQF
                     KPMLGTALRSIVPAGLLSRTTKGDASAELYAGLRRRRGELLKLMDDSHLVRMGFVDADV
                     LRTVLRGLHADTRPLMPLDSTLACELWLRTLSPADTARATAVPVPSPRTVKEI"
     misc_feature    12445..12459
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(12656..12775)
                     /db_xref="GeneID:41544965"
                     /locus_tag="SAVERM_RS40975"
                     /old_locus_tag="SAVERM_7584"
     CDS             complement(12656..12775)
                     /codon_start=1
                     /db_xref="GeneID:41544965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056410.1"
                     /locus_tag="SAVERM_RS40975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAVERM_7584"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_107082961.1"
                     /transl_table=11
                     /translation="MTAETSYETPILTEIGDFADVTRATYRGFWVDFLGGWWF"
     misc_feature    complement(12796..12814)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     misc_feature    13182..13197
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            13227..13607
                     /db_xref="GeneID:41537442"
                     /locus_tag="SAVERM_RS01750"
                     /old_locus_tag="SAV_260"
                     /old_locus_tag="SAVERM_260"
     CDS             13227..13607
                     /codon_start=1
                     /db_xref="GeneID:41537442"
                     /inference="COORDINATES: protein motif:HMM:NF025079.4"
                     /locus_tag="SAVERM_RS01750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_260"
                     /old_locus_tag="SAVERM_260"
                     /product="DUF4158 domain-containing protein"
                     /protein_id="WP_037653002.1"
                     /transl_table=11
                     /translation="MAFLTDEQRRNYGTFNQVPDDGQLAGYFLLDRDARRRAMTCRGAR
                     SQLGYAVQLGTVRFLGTFLDNPEDAPAEVVAYVAEQLGHPGSVLAGYGAERTRWDHQIA
                     IKDAYGYRDLKGDAWWKLRDGD"
     gene            13699..13869
                     /db_xref="GeneID:42527410"
                     /locus_tag="SAVERM_RS42575"
                     /old_locus_tag="SAV_261"
                     /old_locus_tag="SAVERM_261"
     CDS             13699..13869
                     /codon_start=1
                     /db_xref="GeneID:42527410"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS42575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_261"
                     /old_locus_tag="SAVERM_261"
                     /product="hypothetical protein"
                     /protein_id="WP_154696707.1"
                     /transl_table=11
                     /translation="MSERDALRGLRALMWVVIAIEVPVYLVWLVEVSYLTGQQLPRGTE
                     EEDGKPRADTD"
     misc_feature    13717..13719
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14077..14535
                     /db_xref="GeneID:41537443"
                     /locus_tag="SAVERM_RS01760"
                     /old_locus_tag="SAV_262"
                     /old_locus_tag="SAVERM_262"
     CDS             14077..14535
                     /codon_start=1
                     /db_xref="GeneID:41537443"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS01760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_262"
                     /old_locus_tag="SAVERM_262"
                     /product="hypothetical protein"
                     /protein_id="WP_159029063.1"
                     /transl_table=11
                     /translation="MAVAVMELQGAAAANRLLWEGPAERGRTFLLTLLAFAGGAARARI
                     AGGTDVQSGLVGFGQAAELLSRERVASKQTVAAVREPLAQAATAAAPLMRCSAPAVVAA
                     TEQLLNALADVENTARLEAALEAFGRAVNVATPPRLSWWARRRAVSSG"
     gene            complement(14584..14739)
                     /db_xref="GeneID:42527411"
                     /locus_tag="SAVERM_RS42580"
     CDS             complement(14584..14739)
                     /codon_start=1
                     /db_xref="GeneID:42527411"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS42580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_154696708.1"
                     /transl_table=11
                     /translation="MDRWLSSIHIRLRKWRGSGGHSVHHHFLQGMAYKLGSGAVTLLIL
                     WWETRR"
     gene            complement(14846..16444)
                     /db_xref="GeneID:41537444"
                     /locus_tag="SAVERM_RS01765"
                     /old_locus_tag="SAV_263"
                     /old_locus_tag="SAVERM_263"
     CDS             complement(14846..16444)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537444"
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043534.1"
                     /locus_tag="SAVERM_RS01765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_263"
                     /old_locus_tag="SAVERM_263"
                     /product="ISL3 family transposase"
                     /protein_id="WP_042494152.1"
                     /transl_table=11
                     /translation="MFPHLEGVLVEEVSPEGGVLHIVARTVESVPVPCPDCATPSVRRH
                     SGYQRRLADGAVGGRQVSIELTVRRLFCDDQRCARVTFAEQVDGLTVRYGRRTPQLRCL
                     LSAIAVALAGRAGERLAARLPVPVSRTTLLALVMALPDPYAETPRVLGVDEFATRKGHK
                     YGTVLVDCETHAPIDLLPDRESATFAAWLTDHPGVEIICRDRGGAFADGARTGAPDAVQ
                     VADLWHLWHNLAETVKSLVSKHSSCLREPALASESPPEVLHPPLSHAGRLAERARRHHA
                     AVHDLLGQGLTIRAVARRLELSRNTVRRYARAVTWEELATGRWQNLPSTLDPYKSYLHQ
                     RWHEGHTSGAKLHAELRERGFTGSYSVVRDYLRRFRRTSGDRPPPARPPGVRKVTGWIT
                     RNPDRMNDDDQQKLKAILARCPELEAATGHVRSFAAMMAIRSASRLPEWIATARADEHH
                     GLRGFADGLLADLDAVILGLSTEWSSGCVEGRVTDIKLLKRQMAGRAGLPLLRKRVLLV
                     AADRRQHRVTNQTAH"
     misc_feature    complement(16489..16502)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.01"
                     /tool="antismash"
     gene            complement(16627..18837)
                     /db_xref="GeneID:41544672"
                     /locus_tag="SAVERM_RS39200"
                     /old_locus_tag="SAV_264"
                     /old_locus_tag="SAVERM_264"
     CDS             complement(16627..18837)
                     /codon_start=1
                     /db_xref="GeneID:41544672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004926487.1"
                     /locus_tag="SAVERM_RS39200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_264"
                     /old_locus_tag="SAVERM_264"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_010981700.1"
                     /transl_table=11
                     /translation="MTPATPTPPSSTPPSWPQCGHGTTPEDPAGCRGIRVSGHTACLAH
                     LSDADRDAYLAGLSPGNNVDHRGTSFSQDLLDALLDALRDPDTGDPRLGVARFRSATFQ
                     RDVGFRSATFQKWADFGSATFQGNAGFRLATFEGDAGFGSARFEGDAGFGSARFEGDAS
                     FVSATFEGDASFVSATFEGDASFVSATFQSAASLGWAAFQGDVKFESATFQGDAVFGGA
                     DFRGDARFGLAAFERNARFGLARFRGIASFWLVTFHGDAWFRSAIFRGDASFVSATFQS
                     DTDLEAATFSDHTRFDRATFFGDARFVEATFRGDTSFVSATLQSNANFLGVTFERDAKF
                     ESSIFQGDATFVSATFECDACFEQVGFERSASLGPLVCAGRVKLSGAVFGCPVTLSFAT
                     RCLECRRTRWSSTAELRLRYATVDFAHAVFEYPLTIAAEADPFVLHNGRPVAEQSLIDA
                     PDIEVRIASLRGVDAAHLVLSDVDLSGCLFTGTVHLDQIRLEGTCSFASVPRRTHWRRW
                     RPLRFTQRRALAEEGFWRASQPTPVPGWNAAVAGAVHAGPAQLAPVYRALRKAFEDSRN
                     EPGAADFYYGEMEMRRHDRTGSTRTERGLLHGYWLLSGYGLRASRALGWLAAAMLVTIV
                     LLMGFGLPKDSPKQVATGTVPPGDGKVTLEIDKADPQNPTGDRFTSERFEKALTGTLNS
                     VVFRSSGQDLTTAGTYIEMASRVTEPVLLGLAVLAVRNRVKR"
     gene            19182..19742
                     /db_xref="GeneID:41537445"
                     /locus_tag="SAVERM_RS01775"
                     /old_locus_tag="SAV_265"
                     /old_locus_tag="SAVERM_265"
     CDS             19182..19742
                     /codon_start=1
                     /db_xref="GeneID:41537445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145930.1"
                     /locus_tag="SAVERM_RS01775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_265"
                     /old_locus_tag="SAVERM_265"
                     /product="hypothetical protein"
                     /protein_id="WP_037652569.1"
                     /transl_table=11
                     /translation="MMDKAGGVQGQSVCPGKYARVERERRFLLAEPPKPSTVTVTRVIA
                     DRYLVGTRLRLRRADFSDGRCERKLTQKVPVSRPGGVQGLITNTYLSPTEYDLLASLPA
                     AVLSKTRFSVPPLGVDVFDGPLQGLVLAEAEFTTDEETQSFIPPSECVAEVTDDARFTG
                     GRLVETSRQELLGWLAEYGLRPQ"
     gene            20182..20382
                     /db_xref="GeneID:41544966"
                     /locus_tag="SAVERM_RS40980"
     CDS             20182..20382
                     /codon_start=1
                     /db_xref="GeneID:41544966"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS40980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_037652547.1"
                     /transl_table=11
                     /translation="MSAVGLLQFGQGVKAILLVAEEPTLVPQTDGFMGRDGADHEPVKA
                     SSGHAPAASRTPEHFDGLAAQ"
     gene            20865..21215
                     /db_xref="GeneID:41537446"
                     /locus_tag="SAVERM_RS01785"
                     /old_locus_tag="SAV_267"
                     /old_locus_tag="SAVERM_267"
     CDS             20865..21215
                     /codon_start=1
                     /db_xref="GeneID:41537446"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS01785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_267"
                     /old_locus_tag="SAVERM_267"
                     /product="hypothetical protein"
                     /protein_id="WP_010981703.1"
                     /transl_table=11
                     /translation="MLEDPAAHGVDLDCTMVLHELTGDEWPATRAHAEEFVLPHLREHR
                     VRLVQVARASRSLEITVIDDSRQPQRIVERGPWALWDEYESGGTVPQQGGIRLCSLHAK
                     GNWRMPLSPTTC"
     gene            complement(21565..22086)
                     /db_xref="GeneID:41537447"
                     /locus_tag="SAVERM_RS01790"
                     /old_locus_tag="SAV_268"
                     /old_locus_tag="SAVERM_268"
     CDS             complement(21565..22086)
                     /codon_start=1
                     /db_xref="GeneID:41537447"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS01790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_268"
                     /old_locus_tag="SAVERM_268"
                     /product="hypothetical protein"
                     /protein_id="WP_037652549.1"
                     /transl_table=11
                     /translation="MAAAYTLTGGQNTGIPEGDALNGGMQSAGDVGYEHAQVGEEYWAG
                     LPLPWNESGKDIQITRAKFTHVPKGLKVIEYRAFNGDDTDGNVLFARTDGKGSVGDLFK
                     ARNYAGHPMTVKAKTGSHVYYVARVKVTGPIHDNLSGCSYWYRQGSTEFQQQLDCSTIV
                     RLGKPLKYEG"
ORIGIN
        1 gccgccgacg ccaccgcacc ggctccacat ccgaccgata cgaccgctca ccggctcccg
       61 atgatcccgc tcacccccac cactacggcc cagatccgcc ccgtcaccct gctgcgtctc
      121 caagccaccg gcgccttcct caccagcaac tatgcccgcg ccgatgccct catcacgcag
      181 ggtgtccgcc tggccggcac actcggcgaa cccggcaggc acgaacaagc cctgctccac
      241 gccgtgtacg cgagtgccgc gctgctgcgc gacgacctcg acgccgccga agaggcgctg
      301 aagcagggtc tacaggctgc ccggaactgt cccaacgctc gatgccgtat caacctcctg
      361 cttcggcagg cgcgcctggc ccgaatcaga gcccaatccg gccccggtct gcccacacac
      421 ccgaaccccg caccagcagc ggtccagatc tcgctgaagg ccgccaccga agcggcccac
      481 cagcgcgccc tcagcgagcg gtacgtccaa gccgccctcg acctggccct cgacctcacc
      541 gaccgagcca gccaagccga cgcactggac aacctgggat atgtcgctct tgaccgcggg
      601 gacctcaaca ccgcccatca gcaccatgag caggccctga ccctctacca gcacaccgga
      661 aaccgcctcg gccaagccct cgcactgaac aacctgggaa atgtggcccg tgagcgcggg
      721 gacctggaca ctgccgaaca gcaccacaac caagccctga ccttgtaccg gcaggccggc
      781 agccgattcg gccaggccag cgcactagac aggctgggga tggttgccaa ggagagcggg
      841 gacctggaca acgccgagca gcaccacaac caagccctga acctctacca gcagatcggc
      901 caccgctccg gccaggtcgc cgcactcggc aatctgggga acgtcgcccg ggaccgcgga
      961 aagccggaga gcgccaagca gtactacgag caggcaatgg cctccttcca gcagatcggc
     1021 gaccgctccg gccaggccac cgcgctggac catctgggga agctggcccg ggaccgtggg
     1081 gacctggaca ccgccgagca gcaccacaac caggccctgg ccctgtttca acagatcggc
     1141 caccgctccg gccaggccac cgcgctggac aacctgggac atgtagctga agaccgcggg
     1201 gacctgaaca ccgccatgca gcatttcgag caatccctgg ccctcgaacg gcagaccggc
     1261 gaccgcctcg gccaggcaca cgcactggac aacctagggc acctggcctg gtgccgtagg
     1321 gacctggaca ccgccgagca gcaccacaac caagccctgg ccctctaccg gcagaccggc
     1381 agccgacccg gccaagccac ggcgctaatg ggtctgggga gcgttgcccg cggtcgccgg
     1441 gacctggtca ccgccaagca gcgctacgag caggcattga ccctctacca acagaccagc
     1501 aatgcctccg gccaggccgc tgcgctgaac aacctgggga tggtcgctca ggaccgcgcg
     1561 gacctgaaca ccgccaagca gctctacgag caggccctcg ccctgtaccg gcagaccggc
     1621 cactaccccg gcgagcagca ggtcctgcgc ttcatcaacc agctcgacgg tctcgccccg
     1681 ccttcgggcc catgacggcg cctgtacgag ttaggtgtgg acctgcccca gatgcagtgg
     1741 caggcacggg agttgagctg gttggtcacc agggtggtgg cgtgttcgat gtcgtcgcgg
     1801 ttggcgaatg accggccgac gaggacggct ttggggaaga tgcgctacca gccgatcggc
     1861 ttcaccccgc caatcctgcc tccgctagca acggccgctt ggtcatgaac gtgctgccta
     1921 cgtctataga gccgcggttg ctcctttgca aaacagcggc tgagcacacg cggcgggaat
     1981 ctgctcgcgt gcggtgtact ggacagcagc aggttcccca gtgccggctt agacattgtg
     2041 ccgacagacc gctacgcaga cggtggccag ccacggccat gctgccgtca cctggatgag
     2101 ggtgccgttc gggccgccca ccgtcctgac tgccagctcg gctcccgcga tccggaagca
     2161 gcggacgtcg gtgacgtcaa cgcggccccg gcatgccctt cggccccgaa atcgccatcg
     2221 acgcaagcgc accacctctg gaccggctgg tcgctttcac cggccgcgac cccgcttggg
     2281 cgccccccgt cagctgcgct gatgagcgcc tgcggcgtcg tcctcgcttg acggaccggc
     2341 ggggcgggcg gcagctgccg cccgccccgc cggagccgcc cgccctggat catccgcacg
     2401 ccgagaacgg ccgggggcgc tgcctcgtca gcaggctcgc ggcccgctga gcggtgtcgc
     2461 cccagccgga ctccgcgcag ggcaggacgc tgtgggccgg ggtcaacccc gtgagactgc
     2521 gggttcgggc tcggcagcgg actcgggcgc gctttcgctg aggccgaacc ggccgtggaa
     2581 tctgcgcagg aagccgggcg cgtaccaggc cgagtcgccg agcaggcgca tcgcggcggg
     2641 aacgagcaca ccacggatgg cgacagcgtc gatcaggatc gccagtccgc tgccgagacc
     2701 gaacatctgc atgaaactga gcttggccgt accgaaggcg aagaagctca ccgcgagcag
     2761 gcaggcggcg gcggtgacga tgcgcccggt gtgcccgagg ccgttggtga cggcggactc
     2821 ggtgtcctcg cccggggcgt ggagttcctt gatccggctg gtgacgaaca cctcgtagtc
     2881 catcgagaga ccgaagacga tgcagaacat cagcacggtc atcgacatct ccatcggctg
     2941 cgccgtgaag ccgagcaggg aggagagatg gccgtcctgg aagatccggg tcatgatgcc
     3001 gagcgtcgcc accagggtga tcgcgttcag ggccagggcg cgcagcggct gcaccacgct
     3061 gccggtgaag aggaagagca ggacgaaggt ggtcacaacc accaggccga tggcgagcgg
     3121 gatctggccg ctgatggagt gcttggcgtc gaccagttcg gcgtcgatgc cgcccaccag
     3181 cgggtgggtg ccggggggcg gggtgagcgc ccgtacgtcg ccgaccaggc tctgcgccgc
     3241 gtcggacttc ggcgtcaagg agctgacgac gctcgaccct gttcctggac gactggaccg
     3301 tcttcctgcg caccgcccac ggcctccgga cgcaccgcgg cacgaccctg gccccggcga
     3361 agggtcccac cgccatcagc gcccgcaacg tcacctacac ctaccccggt accgccgtac
     3421 ccgcgctggc cggggtcgat ctcgaactca agaggggcga agtcgttgcc ctggtcggcg
     3481 agaacggctc cggaaagacc accctggccc acctcctgac cggcctgtac ctgcccgacc
     3541 acggcaccgt ggaatgggac caggtcgacc tcgccaccgc cgacccccag agtgtgtgga
     3601 agtccgtcgc catggtcccg caggactaca cccggtggcc gctgacctgc cgcgagaaca
     3661 tcaccctcgg catgcccagc gacgaaggtg acgccgccgt actccgagca gccgaggaag
     3721 cgggggcgat ggccgtcgtc gcgcaccttc ccgacggcct ggacacctcg ctagcccgct
     3781 cctggtgggg cggccacgac ctctccggag gacagtggca acgcatcgcc ctcgccaggg
     3841 ccttccacaa ggacgccccc gtactgatcc tcgacgagcc gacctcggct ctggacgccc
     3901 gcattgagca ccaagtgttc tcccggctgc gggagttgtc tgcgggccgc accgcgctgt
     3961 tcatcacaca ccgtcttgcc aacgcccgcg tcgccgacaa agtcatcgtc ctggagaagg
     4021 gcgcggtcgc ggagagcggt acgtacgacg aactcctccg gatcgacggg ctcttcgccg
     4081 aactccaccg gatgcaggaa ggggcggaga gggacatccc gacgccgcgc acgacacgga
     4141 tctgatcctt ccgcgcgacg ccgggcaagg tccagcccga gtcggcggcc tacctgatgg
     4201 acggaggcgt cgccgtgctg ctctcgacaa cagcgcctac accccatcgg acgtagcgcg
     4261 ccgaatcgcc gacgccatcc cggctctgcc gctagcgtcg gtcccctccc ccgccccttc
     4321 gacccccaag gaacatgagc ggacaaccgg caacacccgt catcgacatc cacgtcatcc
     4381 tccgcgacgg tgacaagatc ctcttctccc agcgcggcgg cccgtaacgg ctacggccgg
     4441 tggcacatgc cttccggcaa gctcgaccag ggcgatcccc tgcccgccgg tgctgcccgc
     4501 gaactgttcg aagagaccgg aatcaccgtc gccccgggcc acctccggct cgtccacgtc
     4561 gtgcaccatc gccaagacga cgaggtggaa cggatcggct tcttcttcga agccacggac
     4621 tggcagggag aacccgtcaa ccgggagccg gacaagtgcc tcgccttgac ctggttcacc
     4681 gtgcacgaac tgcccgacgg catcatcgag tacccgcagg ccggactgcg cggatatctc
     4741 gacgagaccg gtcccctcgt cgcacacaac tgggagtagg agactcacct tcagcctgac
     4801 gtgatgtcca gtggttcccg cgtaggcggg gggccgctgc ctgcacccga gccgaggcgg
     4861 tcgccccggg cagccagccg ccgtatcgcc tcgatctcgc gcgcggccac cgggggccct
     4921 cccggattcg ggagggcctc catccggtgc cgtctcaacc cgccagtgga ccagcggcac
     4981 tcgacggggc gtccctgttc ggcaccgccc tggtcgtctc agatcagccg caaaaaaatc
     5041 ttggttgtcg tgtcaagaat ctgagaagct gttgctttat cgatcttggt gggcgtgagt
     5101 tcgaggtcgt cgactcggtc gggtgatctc gtggctggcc gggcatgaaa gcggggcctc
     5161 ccgcacagct cgtgggtgtc gaatccaacc gagcaacagg aggcccctgg tgctgcagtc
     5221 ttccgtgcca gcgtcgatgt cgtccaactc ggcgtctctg tcgtgtgatt gtctcgctca
     5281 ccggttcggg aacgctgggg accggccgta caggcgaccg aagtatccgt cggacatgag
     5341 cgacgcggag tgggccgtcg tacgtgacgc gatgccggtt cccggctggc tcgagggccg
     5401 cggcgggcaa ccggagagct attgccaccg gcagatggtc gacgcggtgc gctatctggt
     5461 cgcgggcggc atcacctggc gggcgatgcc ggcggacttc cccgcgtggg accgcgttta
     5521 tgccttcttc cggcgctggc gggacaaggg cctgaccgcc gagttccacg accggctgcg
     5581 tgaccgggtc cgccaggccg cgggccggga tctggagccg acggcgggca tcatcgacgc
     5641 gcagtcggtg aaggcagccg catcggtgcc ggccgtgacc aggggattcg acggcgggaa
     5701 gaaggtcaac ggccgtaaac ggcacatcgt ggtggacacc ctcggactgc tgctggccgt
     5761 tatggtgacc gcggcctcgg tcaccgaccg ggacgcggga cagacactcc tggcccggct
     5821 gcgcgaacgg cactggcgcg tcacgcgggt gtgggccgac ggaggctaca ccgggcgcct
     5881 ggtcgacttc gcccgcgacg cctggcggat cgcgctgacc gtggtcagac gcagcgacga
     5941 caccagcggt ttcaccgtgc tgccgaagag gtggctggtg gagcgcacgt tcgcgtggct
     6001 gatgcactca cgccggctgg cccgcgacta cgagacgcgc accgacacct cggaggcagt
     6061 gatcaagtgg gcgatgagca cagtcatgag gcgcagcagg cgctcgcgca gcgttctcct
     6121 cctggccggc ggcgcgttcg cgcccggcga gccaacttcc gacggctgta tccagcgcgt
     6181 cgccgtcgat gcgttggagg acacgacgca cggtggcctc ggccggggcg acggggccgc
     6241 ggtccggctc ccggcatggg ccaccgagcc gggccaggac gttgggcggg gcgtcggcgg
     6301 cccactccgc gatcgcggcc agggacttcg ctccggccag gaccgcgcac gcggccaggg
     6361 agaggacgaa ggcgaatggg ttgaaccggg atccttactg tgcgccaacg tacagcgaac
     6421 atcccctgcg taccctggca ttttcgccgc ccaagcggag ccgacctccc ctcttcgcgc
     6481 gggcctgtgt cggccgtggg gaaccctgtg acaagatccg ctggcatgtc atctgtcatg
     6541 tcgtccgcca tgccttcgtt gccttcgtcg cccacgggtc cctcaagaac cggtcgccgt
     6601 ctgctggtcg ccctgctcgc gatgctcgcg acagcaggct ccaccgtggc cgaggccggc
     6661 acgccgtccg gcccggcgcc cggcgccgcg gtgagagcgg ccgaacccgc gacgcctgac
     6721 cgccccagct acgacgtgaa gctgcgcgcc gatggcgacg gctcccactg ggcgggccgg
     6781 cagacggtgt ccttccgcaa cgcctccagc cggcccctgc gtgaggtgta catacgcctg
     6841 tggggcaatg gcgaggacgg ctgcgggaca tccggaagac cgtcccccgt ccgcgtctcc
     6901 cacgtgcgcg gcggcactcc gggccgcccc ggcgtgaagt gcacggcgct gcgcatcgct
     6961 ctgccgaggc cgctcgcacg cggtgagcgg acggccgtct ccttcgacgt ggccctcacc
     7021 gtgcccgcac gcaacaaccg cttcggccgc gaaggcgcgt tccgcttcct gggcaacgcg
     7081 ctgccggtcc tcgccgtgca cgacgcgagg gggtggcacc tcgatccgta tgtgtcgtac
     7141 ggcgagagct tctacaccct ggcgagcgac ttccgggtgc gcctcgacca cccgtccgcc
     7201 ctcaaggtcc cggcgaccgg cagcacatgg acccgccccg gcggtaccgg gcgtacggtc
     7261 acccacagcg tcgccaagcg ggtgcgggac ttcgcatggg cggcgggccc gttccgcacc
     7321 gcgacccaga cctcgcccga cggcgtgcgc gtgaagtcgt attggtcgcc gaacacgccc
     7381 gccgctggtg tccgcctcaa ccgcaaggac ggcgtcgccg ccatcgaccg gttcggcagg
     7441 gagttcggcc gctatccgta cggcgagata gacctcgtga tgacccccgg gttcgccggc
     7501 ggcatggagt accccggcct ggtcatcctt ggcaccgagg aggagggcgg cgccaccgtc
     7561 catgagatcg cccaccagtg gtggtacggc gtcgtgggca acgacgagta caactcaccc
     7621 tggctggacg agagtttcgc tcagtacgcc aacgcgcgct actaccgctg ggacgggttc
     7681 gagtgctcgc cggacgactc ctggccgagc gccaccgccg cgctcaccaa ctcgatggcc
     7741 tactggtcta cacaccgtgg cgagtacttc caggtcgtgt acgggatcgg cccctgcgtc
     7801 ctggccgacc tggagcacgt cctcggggcc ggcaccatgg cgcgcctcat caagaagtac
     7861 gcccacgacc actggtacgg cgtctccacc accgtcgact tcaagaaggc cgcacagtcg
     7921 atgacgcaca gggacctcgg ccccttctgg cggaagcacc gcatccgctg aagtcgcact
     7981 ccgctcgcgg gtgacgggcg taccccggcg gcgccacgat gacggtgacc gacggggtag
     8041 gcgggcaggg cggcgtcgtt ccggcggtgc atccgggttg atggggcttc aggagctggg
     8101 gcaggactgc ggagtggtcg gcgggggctg acgcggaggc aggcacgact tccggtgatc
     8161 atgaggtgtc gagtccctga tcaccacgac ggaagaccgt gcctgcccgc tcatcctcgc
     8221 tcatcgcgcg ctctctgggc caactcgccg gcaccgcgcc gaccgtcccc gatgacctcc
     8281 ccggcctgct gacctgcctg gctcaggtgc ccgatccccg ccgggaccag ggccgacgcc
     8341 acccgctcgc cttcgtcctc tccctggccg cgtgcgcggt cctggccgga gcgaagtccc
     8401 tggccgcgat cgcggagtgg gccgccgacg ccccgcccaa cgtcctggcc cggctcggtg
     8461 gcccatgccg ggagccggac cgcggccccg tcgccccggc cgaggccacc gtgcgtcgtg
     8521 tcctccaacg catcgacggc gacgcgctgg atacagccgt cggaagttgg ctcgccgggc
     8581 gcgaacgcgc cgccggccag gaggagaacg acagcgaccg gcggcccctg ccctccctcg
     8641 ccgtggacgg caagaccgtg cgcggtgccc gccgcaccga cggcacccag gtccatctgc
     8701 tagccgcgat gacggggacc ggcctggtca ccgcccagcg cgaggtggac gccacgacca
     8761 acgagatcac cgtcttccag cccctgcttg ccccgctcaa cctgcacggc acggtggtca
     8821 ccttcgatgc cctccactcg cagaccgccc acgcgcgctt cctcgtcgag gacaagcacg
     8881 cccactacat cgcgctgatc aagggcaatc agcccaccct gcaccagtgg ctgaaggccc
     8941 tgccatggcg ggaagtgcca ctcctggaca agacgcgggc caccgcgcac ggccgcgacg
     9001 agatccgccg gatcaaggcc gccgccgtcg ccgggatcgc gttcccacac gcggtgcagg
     9061 ccgtccagat cgagcgccgc cgacggatcg tcaccaccgg caaggtcacc cttgaacgca
     9121 tctacggggt gaccgacctg accgcggagc aggccgacgc aaccgagatc gcccgccgcg
     9181 tccgcggcca ctggggcatc gagaacaaga tccaccacgt cagggacacc acgtacgccg
     9241 aggacgcctc ccgcgtacgc accggcaccg ctccacgtgc aatggcatcc ctgcgcaacc
     9301 tggccatcgg cgctctccga ctcgccaacc agacgaacat cgccgctgga ctccggcacc
     9361 acacccgcga cgccaaccgt ccactgatca ccctcggcat catgtgatca accaggacac
     9421 atcacctgaa cgacgcggcc ctgggcatcg accgcatcga gatccatcac gatgccgcca
     9481 accctgccag cggggccgtc gcccgccgct tgggattcgc tgaggttgag cgcatacgag
     9541 caactgacgg gcacgtcgct cctggcgaag tgggaatcga tgtcatttgg cgtatgacgg
     9601 cagaccaatg gaaggcaagg acagccgagc acgctcaaca agcgagctga gtagaggtaa
     9661 atgccataga gatcggcgta cagacgcagg ttctcctggg cagtcaggtc atcgtcggta
     9721 gtggattcct ggaagacgac accgatttgg cggcgcacgt cgtgagggga gcgggtgatg
     9781 tcggcgccag cgacctgggc gtggccggtg gtggggcgca gggtggtgca cagcatcccg
     9841 atggtggtcg acttgccggc gccattgggg ccgaggaagg caaagagttc gccctgggcg
     9901 acggtgaggt ccaggccttg gacggcttcg acatctccgt aggtgcggcg caggccccgg
     9961 gtaacgattg tcccaggggg tgaagtgggg tcggccgggg tcatcggcgg gccgggacgg
    10021 acatcaccag gtggaagtcg gtgacggcgt cagggtcctc gccgaccgcg tcaccgtcca
    10081 cggcgaccca ggcgtgcgcg gcgaagggtc gagtggtcac gccagtgcac cattgtggcc
    10141 aggtgccgcc caggcggcac agtagcgcag tggcgatgga acgctccagg cagcgaggcc
    10201 cggcgatggt gacgctgacg gacaccacgg cgttgcgggc ttgcagcgcc tggggcagat
    10261 cggccggacg agcgccccgg ctcgcgagtt cgaggacctg acgcaggcgt cgcggcgata
    10321 cgcgcgccag cagtcgggcg gcggtcacgg tgactagggc ggcggggcgc tggttccacg
    10381 gaatggcggt ggacggttcg agagtcagct ggccgctcat gacgcggcca ccttggcggt
    10441 gcgcagggcg tgcagcaggt tgtcgacgtc ctgctcgacc tgggcggttc cggcgtcggg
    10501 gaaacgttga cacaggctgg caacgacgcc ttggggggac gtaccgtcaa gcagggcgcg
    10561 cagggccagg gcgcccgtgc cgttgagcag ccagtagcgg ccggtgcgtt cgtcgagcaa
    10621 gaccgtaccg tgctcggtgt cggtgacaga cacttcaggt gccagggcaa agttcatcat
    10681 atttccttga cggttcgagg ggagggaacg ggcacggcgg tggcccgggc ggtgtcagcc
    10741 ggggacaggg tgcgcagcca caattcgcag gcgagggtgg agtccagggg catcaggggc
    10801 cgggtgtcgg cgtgcaggcc gcgcaggacg gtgcgcagga cgtcggcgtc gacgaagccc
    10861 atgcggacca gatgggagtc gtccatgagc ttgaggagct cgccgcgccg acggcgcagt
    10921 cccgcgtaga gctcggcgct ggcgtcgccc ttggtcgtgc ggctgagcag gccggcgggg
    10981 acgatgctgc gcagggccgt gccgagcatg ggcttgaact ggcccagggc cacccggtcc
    11041 tccagccgta ccgccagaat ggcctccagg acccggtcgt cggtgaaggg tgcgtggaaa
    11101 gtgacgccgg tatgggcgcc gatatgggag ttgcggcggg tggcattgcc gttgatgcgg
    11161 gtgagccgga tcatctcgtg ctggacgggc agggtggcca gcggctgagg tgtggctgcg
    11221 agggcggcga ggagttgacg ccggacggtc gccgcggcgt gcggggtggc ccagggcggg
    11281 agtttcggca gtggctccca gtctgctccg gctccccaat cgtgcctgtc ggcagggaag
    11341 ttgctgcagg cggccagcca ctgcgtgtat gagggtgcag aggcgagggt acgggcggtt
    11401 gtagtcaggg gccagcggcg catggagcgc agggcgcgca agtgtggcag ggcggcgaga
    11461 ggatgccgtc ggacgagggc gtgcagagcc atcgggctag ggtggaagag ctcgtcaccg
    11521 ccaatgcctt ggaggtgacg tcgcgagccg tgcgctgcgg caagccgggc caagtgctcg
    11581 gtggtcgcgc gggaccgtac gaacgtcagg gggccttctc ggtcatggac ggcgtgggcg
    11641 agaggcgcgt accagtccgg ggcttgaccg gggccgacca gaaggtgccg ggcgcccggc
    11701 aaagcggcct cggcctggcg ggcccagtac cgatcgtcgc tggaccggcc cagcgcctgg
    11761 tagtggaccg tcaccaggtg ggcgtcgtgg cggtcggcgt cggccaggaa gcacaggctg
    11821 gtggagtcca ggccgccgga caggtcggca ctcacgacct cctggcccgc ggtacaggtc
    11881 gccaccgcct cggccagcgc ctgtcggatc atgtcgccgt tgcccagggg gcggtccgga
    11941 tccggcgcag tccaccattg gcgggtacgc cccgtgccgt ccctgccgat ctcaaggcag
    12001 tgcccggtcg ggggtgagca cacgccacgc cacaggctcc gctcgctcag aggccacggc
    12061 ggcccgaagg gcgagagcag tgccagtgcc acctgatcct cgtcgatgtc ggccccgatc
    12121 cggtcggcca gtgcctgggg gcggtcggcg gccagggtca ctccggcgac cgtggcgtag
    12181 tagatctgac acgccgctga gagcgtgccc tggacgcgca cctctccgtt taccgacgcc
    12241 acgaggtgga agcttccagc ggctgttgcg gctaggccgt cgaggtcgcg gaccgaccgg
    12301 acgtcgcgca gccgccgggt gaggacgtct gcgtccgcgg tggtgcggcc gagcagagcc
    12361 acgcgatgcg ggcccacagc ggtgaccatg acgtcctctt cgttccagca gcccacaatc
    12421 cacggtcgcc ccgagtggtg ctcaatcacg tgcgtcggtg gcggtccggc agttggcatg
    12481 agcgccaggg ccgcagcgcc ggccgggtgg tcgggaagta ccaagaattc catgccggtc
    12541 ccttccacaa gggtgagtaa gaggtgggga agacgcacgg ctggcacgga tcgtctccgt
    12601 gccagccgcc gctcaggagt gtttagagca ggtgctcagc tccgccgaag gcggatcaga
    12661 accaccagcc gccgaggaaa tccacccaga agccgcggta ggtggcgcgg gtgacgtcgg
    12721 cgaagtcacc gatctcagtg agtatgggcg tctcgtacga ggtctctgcg gtcatggaag
    12781 gtcaactcct tgagttggat actgcgaaca gttgggtgtt ccccgagcca gcacgacagt
    12841 gctggctggg tgtgggggga tcttgattcg cgtggcccga tgcaccgctc cgggcaagcg
    12901 ccatggagca gccggtgagg agactcactc ggtcggccgg gcacaacaga gcctgcggga
    12961 ggggaccgga cagagcaaca gcagagccat gtcccggaca gctccgctgc tgtcctacct
    13021 ggtcagatcc ttgtccgggt tcttgtcccg gtccggaggc gagacaagac tgggcgctga
    13081 cgccttgtcg gtgagcttgc actggttgtc cacggcaccc agtagtggcc tatctcagcg
    13141 ccgtactgac ccgatgccac atcagtgatc acgtgactta aggtgagcgc cgtcacaggg
    13201 caacagagat ggggagggcg gggccggtgg cgttcttgac cgacgaacag cgccgtaact
    13261 acggcacgtt caaccaggtg cccgacgacg ggcagctcgc cggctacttc ctgctggacc
    13321 gcgacgcccg gcggcgggcg atgacctgcc ggggcgcgag gtcacagctc ggctacgccg
    13381 tccagctcgg caccgtgcgg ttcctgggca ccttcctgga caaccccgag gacgcgcccg
    13441 ccgaagtcgt cgcctacgtc gccgagcaac tcggccaccc gggatcggtg ctcgccgggt
    13501 acggcgccga gcgcacccgc tgggaccacc agatcgccat caaggacgcc tacggctatc
    13561 gggatctgaa gggcgacgcc tggtggaagc tccgggacgg tgactgacct ccactccttc
    13621 gggtgaggcg ccctggcggt gctggggcag ggtcagtacg ttcccctgga cttgatgatc
    13681 gagggggaga gccaacggat gagcgagcgc gacgcgttac gggggctgcg ggccttgatg
    13741 tgggtggtga tcgccatcga ggtcccggtg tacctggtgt ggctggtcga ggtcagctac
    13801 ctgaccgggc agcagctgcc ccgcggcacc gaagaagaag acgggaagcc ccgggccgac
    13861 accgactgat gccgacgggc aacaggcccg tacgggttgt gcgtcaggta cgcaacgagt
    13921 cggacgccgg gctggtgcac gatcagcctg cggggatgga caagttgatc gagttggcca
    13981 gcacgctcgt atcgggggcg ttcatcgacc aaccgctccc gcaaccgcca ggagcagcag
    14041 gccgagatcg gtgcgctgcg ggtgcaggcc gacgcgatgg cggtggcagt gatggaactg
    14101 cagggcgcgg ccgccgccaa ccgtctgctg tgggaggggc cggccgagcg gggccggacg
    14161 ttcctgctga cgctgctcgc cttcgcgggt ggcgccgccc gggcccgcat cgccggcggc
    14221 acggatgtgc agagcgggct ggtgggcttc gggcaggcgg ctgagttgct gagccgggaa
    14281 cgggtggcca gcaagcagac cgtggccgcc gtgcgggagc cgctcgctca agccgccacc
    14341 gccgccgccc cgctcatgcg ctgctccgcc ccggccgtcg tcgctgccac cgagcagctg
    14401 ctgaacgccc tggcagacgt ggagaacacc gcgcgcctgg aggctgccct ggaggccttc
    14461 ggccgggccg tcaacgtggc caccccaccg cggctgtcct ggtgggcgcg gcggcgcgcc
    14521 gtctcgtcag gatgatggcc ggcccctggc tgcccatgct gaggctgcgg gcccgcagcc
    14581 tagtcagcgg cgggtctccc accacaggat cagcagcgtc acggcgccgc tgcccagctt
    14641 gtaggccatg ccctgaagga agtggtgatg gacactgtgt ccaccgcttc cgcgccattt
    14701 ccgcaggcga atgtgaatgg acgacagcca tctgtccacg gggcgtggat gcttgtctcg
    14761 tgaattcacg ctaggctccg tactggtgtt agttgctctc ggcgacgcct gaattctggc
    14821 tcagtcaaga tttccgtgaa gccgatcagt gagccgtctg gttcgtaact ctgtgttgtc
    14881 ggcggtcggc ggcgacgaga aggacgcgct tgcggagcag ggggagtccg gctcggcctg
    14941 ccatctgccg cttgagcagc ttgatgtccg tgactctgcc ctcgacgcag cccgagctcc
    15001 attccgtgct cagtccgagg atgacggcgt cgaggtcggc cagcaggcca tcggcgaagc
    15061 cgcgcaggcc gtggtgctcg tcggcgcggg cggtggcgat ccattcgggc agtcggctcg
    15121 cgctgcggat ggccatcatc gcggcgaagg accggacatg tccggtggcc gcttcgagtt
    15181 cggggcagcg ggccaggatg gccttgagtt tctgctggtc gtcgtcgttc atgcggtcgg
    15241 ggttccgggt gatccagccg gtcaccttgc ggaccccggg cggccgcgct gggggcggac
    15301 ggtcgcccga cgttcggcgg aagcgccgga ggtagtcgcg gacgacggag taggaccccg
    15361 tgaagccgcg ctcacggagt tcggcgtgga gcttggcacc gctggtgtgg ccctcgtgcc
    15421 accgctggtg cagataggac ttgtaggggt ccagagtgct ggggaggttc tgccagcggc
    15481 cggtggccag ttcctcccag gtgacggcgc gggcatagcg gcggacggtg ttgcgggaca
    15541 gctccaggcg gcgggcgacg gcccggatgg tgaggccctg gccgaggaga tcgtgcacgg
    15601 cggcgtggtg ccgccgggcc cgctcggcca gccggcctgc gtgggagagc ggcgggtgca
    15661 ggacttcagg gggtgactcc gaggcgaggg cgggttcacg aaggcaggaa ctgtgcttgc
    15721 tgaccaggga cttcacggtc tcggcgaggt tgtgccagag gtgccagaga tctgcgacct
    15781 ggacggcatc tggggccccg gtgcgggcac cgtctgcgaa ggcgccgccc cggtcacggc
    15841 agatgatctc cactccgggg tggtcggtca gccacgctgc gaacgtcgcc gactcccggt
    15901 cgggcagcag gtcgatggga gcatgggtct cgcagtcgac cagcacggtg ccgtacttgt
    15961 ggcctttgcg ggtggcgaac tcatcgaccc ctagcacccg gggcgtctcg gcgtacggat
    16021 cgggcagggc catgaccagg gccagcaggg tagtgcggct gacaggcacc ggcagccggg
    16081 ccgcgaggcg ctctccggcc cggccggcca gggccaccgc gatcgcgctc aacaagcacc
    16141 gcagctgcgg cgtccgacgc ccataccgca cggtcagccc gtcgacctgc tcggcaaagg
    16201 tcacccgtgc acatctctgg tcgtcgcaga acaggcggcg gacggtcagc tcgatggaca
    16261 cctgacggcc gccgaccgca ccgtcggcga gacggcgctg gtatccgctg tgccgtcgca
    16321 ccgagggcgt tgcgcagtcc gggcacggca ccggaaccga ctccacggtt cttgccacaa
    16381 tgtgcaacac cccaccctcg gggctcactt cttccaccag caccccttcg aggtgcggaa
    16441 acatggtctt cagcagctcc ccacactcgg cgagtatcac gcggcctgtg acggagcgtc
    16501 accggcgcac aggcgcacga tcggcttcac ggaaatcttg actgagcctg aattctggcg
    16561 tcgccgagag cttcagtgtc ttgttgctgc ggcgccttgt cgggtccctg gcgtgtgaac
    16621 tgcggatcag cgtttgacgc ggttacggac ggccaggacc gccaggccca ggaggacggg
    16681 ttcggtcacg cgggacgcca tttcgatgta ggtgccagca gtggtcaggt cctgtccgga
    16741 ggagcgaaag accaccgagt tgagcgtgcc ggtcagtgcc ttctcgaagc gctcgctggt
    16801 gaacctgtcc ccggtggggt tttggggatc agccttgtcg atctcgagag tgaccttgcc
    16861 atcgccgggg ggcacggtgc cggtcgctac ctgcttcgga gagtccttcg ggagcccgaa
    16921 gcccatcagc agcacgatgg tgacgagcat ggctgcggcg agccagccca aggcccggga
    16981 ggcgcgcagg ccgtagccgg acagcagcca gtagccgtgc agcaggccgc gttcggtgcg
    17041 ggtgctgccg gtgcggtcgt ggcggcgcat ctccatctca ccgtagtaga agtccgccgc
    17101 ccccggctcg ttcctgctgt cctcaaacgc cttgcgcagc gcccggtaca ccggcgccaa
    17161 ctgtgccggt ccggcgtgta cggcgccggc cactgccgcg ttccagcccg gcactggtgt
    17221 cggctggctt gcacgccaaa agccttcttc ggcgagggcg cgtcgctggg tgaaccgaag
    17281 ggggcgccag cgccgccagt gcgtgcggcg cgggacgctg gcgaaagagc aggtgccctc
    17341 cagccggatc tggtccagat gcacggtgcc ggtgaacagg catcctgaca ggtcgacgtc
    17401 ggagaggacc agatgggccg cgtctacccc ccgcagcgaa gctatgcgaa cttcgatgtc
    17461 gggcgcgtcg ataaggctct gttctgccac tggtcgtccg ttgtggagca cgaaggggtc
    17521 ggcctccgcg gcgatcgtca gggggtactc gaagaccgca tgggcgaagt ccaccgtggc
    17581 atagcgcagg cgcagctcgg ccgttgacga ccaacgcgtc cgtcggcact ccaggcagcg
    17641 cgtggcgaac gacagggtca ccgggcatcc gaacaccgcc ccggacaact tcacccgccc
    17701 ggcacacacc aacggcccga gactggccga ccgctcgaaa cccacctgct cgaagcaggc
    17761 gtcgcactcg aaggttgccg acacgaaggt ggcgtccccc tggaagatcg atgactcgaa
    17821 cttagcgtcg cgctcgaagg tcactcccag gaagttagcg ttgctttgga gagtcgctga
    17881 cacgaagctg gtgtcaccgc ggaaggtcgc ctcgacgaac cgggcgtcgc cgaagaaggt
    17941 agccctgtcg aatcgggtgt ggtcagagaa ggtcgccgcc tccaagtcag tgtcgctttg
    18001 gaatgtcgct gacacgaagc tggcgtcgcc acggaaaatc gccgacctga accaggcgtc
    18061 gccatgaaag gtcaccaacc agaagctggc gatgccccgg aatctcgcca acccgaaccg
    18121 agcgttgcgc tcgaaggccg ccaacccgaa ccgagcgtcg cctcggaagt ccgcaccccc
    18181 gaaaacggcg tcgccctgga aggtggccga ctcgaactta acgtcgcctt ggaaggctgc
    18241 ccacccgagg ctggcggcgc tttggaaggt cgctgacacg aagctggcgt cgccttcgaa
    18301 agtagccgac acgaagctgg cgtcgccttc gaaagtagcc gacacgaagc tggcgtcgcc
    18361 ctcgaagcgg gccgacccaa acccggcgtc gccctcgaag cgggccgacc caaacccggc
    18421 gtcgccctcg aaggttgcca acctgaaccc ggcgttgcct tggaaggtcg ccgacccgaa
    18481 gtcggcccat ttctgaaagg tcgccgacct gaatcctacg tcgcgctgga aggtcgccga
    18541 cctgaaccgg gcgacaccga ggcgggggtc gccggtgtcg ggatcgcgga gggcatcgag
    18601 gagggcatcg agcaggtctt ggctgaagga agtaccgcgg tggtcgacgt tgttgccggg
    18661 gctcaggccg gccaggtagg cgtcgcggtc ggcatcggaa aggtgggcga ggcatgcagt
    18721 gtggccggat acgcggatcc cgcggcagcc ggcggggtcc tccggtgtgg tgccgtggcc
    18781 gcactgcggc cacgacggcg gggtgctaga cggtggtgtg ggtgtagcgg gcgtcatgtt
    18841 cctaggacgt accggggccg tcggacagtt gccgaatccg gccgcagctg tccgttctca
    18901 tcgaggttcg ctgaccgaag gtctctgagc tgggagttgt catcttgggg tgacacggtt
    18961 ccgcccgctg gagtgtcacg tgctctgcgg aatgatcagc agagcacgag tgtgtcatcg
    19021 agcatggtga ggggcggatc gctgagctgt ggttcgtcat cttcgccgat actggcctcg
    19081 ggctcttctc actggacttg gcagtatccg gaagggcgcg agatcggggt ctgtggtctt
    19141 gatgtggccg cgcagggaga agcagctgag aagctgtgct catgatggac aaggccggtg
    19201 gagttcaagg tcagtcggtt tgcccgggga agtatgcacg cgttgagcgt gagagacggt
    19261 tcctgctggc tgaacctccg aagccgtcga cggtaacggt cacccgtgtg atcgccgacc
    19321 gttatctggt gggaacacgt ctgcggcttc gacgtgcaga tttctcagac ggccgctgcg
    19381 aacgcaaact cactcagaaa gtgccggtct ctcgtcccgg cggtgttcag ggcctgatca
    19441 ctaacaccta cttgtccccg acggagtacg acctgctcgc gtcgctgcct gccgcggtgc
    19501 tgtccaagac gcgtttcagc gtgcctccct tgggcgtcga cgtcttcgac ggtcccctgc
    19561 agggtctggt cctggctgag gccgagttca ccaccgacga ggagacccag tccttcattc
    19621 ccccttcaga gtgcgtggca gaggtgacgg acgacgcccg cttcactggg ggacggcttg
    19681 tcgagacctc tcgccaagag ctgctcgggt ggctggctga gtacgggctc cgcccgcagt
    19741 gacatcaaag acggcgctct ctccgcccgc cacaagcccc aacgacacga gcagcagtct
    19801 aacggggccg actaccggtc ctcggagctc cttgacctgg caggccaagg tcacggggcc
    19861 acctatcagt cttcgcggga ttgatcccga gtctgcgtgc ggcttcctgg cggaagtctt
    19921 gatcagcagg ccagtgcggt gaggtgagca aagccgtgag cttgacggtc tcggggtaga
    19981 ttgcgagttc tatccggggc tgggaggggc gacgggggtc tcgtctccgt aggggtcctc
    20041 gccgagctgg tcgatgcgtt tgttccagcg ttgtcgcaga gctgacggct ttccgtcctg
    20101 gaaccagtcc cggaggcagt cgcgggcaac ggcgtactcc cgagcgagga tggaggctcg
    20161 ggttcgacgg acaagacggc aatgtcggcg gttggcctgt tgcagttcgg gcagggcgtg
    20221 aaggcgatac tgctcgtcgc cgaggagcca acgctggtgc cgcagacaga cggcttcatg
    20281 gggcgggatg gtgcggacca cgagcccgtg aaagcctcgt cgggccatgc accggcggca
    20341 agccggacgc cggagcactt cgacggcctg gccgctcagt gactgcagac ggttctcggc
    20401 cggttcgccg atcacggcga gggctgggat cgcgtgagac aactcggcag ccgttcgccc
    20461 cgtcagggcg gagagccggc agagggtctc gggtgtccag cgaccggggc ggttgtcgtc
    20521 gcggcggtga tgccggttat gcccgagcag gatgggccgg aactggaccg gcaggcggtt
    20581 ggcgtcggcg agccggttga gataagagca gccacttgac tccctcagcc gcaacacgac
    20641 atgaggcaac tcagcgtatg tccacagaac atcggtacgc cgcctacatc ggaccgcgca
    20701 ccggccgccg cctcgccgtc acctcctacc cgtacccggc ggccgaccaa gggggtgcgg
    20761 ccgcatgaac gccaccgccc gcaccgcagc cggcctgggc ttcgagggca tcgagctggt
    20821 catcaattgg ggattggggg tcgactcccg cgtacttggt gaagatgctg gaggacccgg
    20881 ccgctcacgg agtcgacctg gactgcacca tggtgctgca cgagctcacc ggggacgagt
    20941 ggccggccac ccgcgcccac gccgaggagt tcgtgctgcc gcaccttcgc gagcaccgtg
    21001 tccggctcgt tcaagtcgcc cgggccagcc gctcgttgga gatcacggtc atagacgact
    21061 cccgccagcc gcagcggatc gtcgagcggg ggccctgggc actgtgggat gagtacgagt
    21121 cgggcggcac cgttccccag cagggcggta ttcggctctg cagcctgcat gccaagggca
    21181 actggcggat gcccttgtca ccgactacct gctgaggaac accgcgcccg cacgctgtcc
    21241 aatgacgcaa gcaccgacgg cggtctcgac ggagggcgtg atcactcctc cgtgcgccga
    21301 aggagtggtc tccaaactgc tgggtcgcac ggctcaggcg atggccgtgg ccaggagcgt
    21361 gagtctcgcg ggagccaccc ccatgtcgaa ccgtgtactg ggaggacacg cagagctgat
    21421 gactcctaaa caagcgaacc tgaactcccg ccaacccctt ctggccagct gatcagcacc
    21481 tcccccacaa cgggggagcc tcaaccgtga tgacgctggg ctgcgccccg caccagatcg
    21541 ctggtggttg gggcgaagcg gcgtctagcc ctcgtacttg aggggtttcc cgaggcggac
    21601 gatggtcgag cagtccagtt gctgctggaa ctccgtggaa ccctgccggt accagtagct
    21661 gcagccggac agattgtcgt ggatcgggcc ggtgaccttg acccgtgcca cgtagtacac
    21721 gtggctgccc gttttcgctt tcaccgtcat gggatggccg gcgtagttgc gagccttgaa
    21781 caggtcgccc acgctgccct tgccgtcggt gcgtgcgaac aggacattgc cgtcggtgtc
    21841 gtcgccgttg aaggcccggt actcgatgac cttcagaccc ttggggacgt gggtgaactt
    21901 cgcccgcgtg atctggatgt ctttgccgga ctcgttccag gggagcggca gtccggccca
    21961 gtactcctcg ccgacctggg cgtgttcgta gccgacgtca ccggcggact gcatgccgcc
    22021 gttgagggcg tctccttcgg ggatgccggt gttctggccg ccggtcagcg tgtaggcggc
    22081 ggccacggcg agaaggaggg cgacgaacag gccaagggtt cgtctagttg gagtagaaga
    22141 cgccaggctt gtcgtgaacc ggcccattct tcccccagat caggtgtgtc gcgttcctac
    22201 gggtaccggc tatgatcttc tgcttgtggt tggtgtcgta gccggtggtg acgccgagtc
    22261 cgacgcccat gaagttgacg gcgttgccga acttggcact cttcttcctg gtcagctgga
    22321 agtacgtgcc gttgtcgacc ttggcgtggt agctcttcgg ggccctgccg tagttgccgg
    22381 agccgtcct
//
