LOCUS       NC_003155              21008 bp    DNA     linear   CON 12-JUL-2024
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893, complete sequence.
ACCESSION   NC_003155
VERSION     NC_003155.5
KEYWORDS    RefSeq.
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ikeda,H., Kazuo,S.Y. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and development
            of genome-minimized hosts for heterologous expression of
            biosynthetic gene clusters
  JOURNAL   J Ind Microbiol Biotechnol 41 (2), 233-250 (2014)
   PUBMED   23990133
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete genome sequence and comparative analysis of the industrial
            microorganism Streptomyces avermitilis
  JOURNAL   Nat Biotechnol 21 (5), 526-531 (2003)
   PUBMED   12692562
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: deducing the ability of producing secondary metabolites
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12215-12220 (2001)
   PUBMED   11572948
REFERENCE   4  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) Contact:S Omura Kitasato University,
            Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara,
            Kanagawa 228-8555, Japan URL
            :http://avermitilis.ls.kitasato-u.ac.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009765.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:55:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,040
            CDSs (total)                      :: 7,942
            Genes (coding)                    :: 7,651
            CDSs (with protein)               :: 7,651
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 293
            CDSs (without protein)            :: 291
            Pseudo Genes (ambiguous residues) :: 0 of 293
            Pseudo Genes (frameshifted)       :: 128 of 293
            Pseudo Genes (incomplete)         :: 220 of 293
            Pseudo Genes (internal stop)      :: 25 of 293
            Pseudo Genes (multiple problems)  :: 77 of 293
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:08:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 76072
            Orig. end                         :: 97080
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BA000030.4.
            On Mar 29, 2016 this sequence version replaced NC_003155.4.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21008
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11008](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11008
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            892..2358
                     /db_xref="GeneID:41537265"
                     /locus_tag="SAVERM_RS00770"
                     /old_locus_tag="SAV_68"
                     /old_locus_tag="SAVERM_68"
     CDS             892..2358
                     /codon_start=1
                     /db_xref="GeneID:41537265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720996.1"
                     /locus_tag="SAVERM_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_68"
                     /old_locus_tag="SAVERM_68"
                     /product="hypothetical protein"
                     /protein_id="WP_037651981.1"
                     /transl_table=11
                     /translation="MTDRVLELLRTRPDLAELAAFPFGFDVSRAYHVEAVHLASGAPLE
                     PIAGDDTGGTYFLCGATAVLHASSEGDAVLLADSVGEALEILVRLPWWCENISAELDEE
                     DLLAEVRAADHAAREEFAPELDAQRAALISGLGLPDRPLAELLAMSQSAAGRTEPDHVL
                     LNSRELCAYRLEESFRQPLRDVVLGPGREVLERMRRGGLGAREEAAGDPVLRAGVLRAA
                     QYDRRDGDLPLLRLLLEHESAARTERFEERRLAAVLVALHGREGDVSLLRSATGGQVTD
                     SAEAVEWARAEEAKRYGRDVAAESEFTWIELARRQGRIERARVALIRMLDDTGPDADRL
                     RELSRALERIGDYAQAARAQFNLLSLQDTAWDRASEAYVLARLERRRGDLVAAGRALER
                     ARAAVGAGGTTPGGADCQWHRRGLGRLITEQHLELTLAAAEAGDAELARATMGHGRLLL
                     DTVGKESAKALSRLSTRAKWAVAGLRPPGA"
     gene            2661..2900
                     /db_xref="GeneID:91294736"
                     /locus_tag="SAVERM_RS44065"
                     /old_locus_tag="SAV_69"
                     /old_locus_tag="SAVERM_69"
     CDS             2661..2900
                     /codon_start=1
                     /db_xref="GeneID:91294736"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAVERM_RS44065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAV_69"
                     /old_locus_tag="SAVERM_69"
                     /product="hypothetical protein"
                     /protein_id="WP_010981505.1"
                     /transl_table=11
                     /translation="MATTHADALRSQRGIWIDAGTRDEWFLDLGALAFRDALTEAGVAD
                     DIVHFELFEGGHHAVEYRMPPALAWLAHRIADRP"
     misc_feature    complement(3074..3087)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.08"
                     /tool="antismash"
     gene            3353..3778
                     /db_xref="GeneID:41537267"
                     /locus_tag="SAVERM_RS00780"
                     /old_locus_tag="SAV_71"
                     /old_locus_tag="SAVERM_71"
     CDS             3353..3778
                     /NRPS_PKS="Domain: Polyketide_cyc (10-117). E-value:
                     1.8e-18. Score: 59.0. Matches aSDomain:
                     nrpspksdomains_SAVERM_RS00780_Polyketide_cyc.1"
                     /codon_start=1
                     /db_xref="GeneID:41537267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983504.1"
                     /locus_tag="SAVERM_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_71"
                     /old_locus_tag="SAVERM_71"
                     /product="SRPBCC family protein"
                     /protein_id="WP_010981507.1"
                     /transl_table=11
                     /translation="MSASLVETVDIEAPVAVTWALWSDVSRWPSFLSHVRLVEPLDERR
                     FAWQLSLPGADKNFVAELTEVIPGDRIAWQTTEGVHHAGVVTFHRLSDTSSRVTLQIEY
                     DPKGFVEHIGALTNLDSTLANYDLGEFQKLAETAAAG"
     aSDomain        3383..3703
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAVERM_RS00780_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="1.80E-18"
                     /label="SAVERM_RS00780_Polyketide_cyc.1"
                     /locus_tag="SAVERM_RS00780"
                     /protein_end="117"
                     /protein_start="10"
                     /score="59.0"
                     /tool="antismash"
                     /translation="IEAPVAVTWALWSDVSRWPSFLSHVRLVEPLDERRFAWQLSLPGA
                     DKNFVAELTEVIPGDRIAWQTTEGVHHAGVVTFHRLSDTSSRVTLQIEYDPKGFVEHIG
                     ALT"
     misc_feature    complement(3925..3941)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.42"
                     /tool="antismash"
     gene            4129..>4335
                     /db_xref="GeneID:41537268"
                     /locus_tag="SAVERM_RS00785"
                     /pseudo=""
     CDS             4129..>4335
                     /codon_start=1
                     /db_xref="GeneID:41537268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981789.1"
                     /locus_tag="SAVERM_RS00785"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHHGARREAFAVASRIWDDFFDCLPVRGDTLFELTDALLCADGPV
                     TALVDLTLTAAHRRGHGAMYDALN"
     gene            complement(4488..6143)
                     /db_xref="GeneID:41537269"
                     /locus_tag="SAVERM_RS00790"
                     /old_locus_tag="SAV_72"
                     /old_locus_tag="SAVERM_72"
     CDS             complement(4488..6143)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537269"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118727.1"
                     /locus_tag="SAVERM_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_72"
                     /old_locus_tag="SAVERM_72"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_010981508.1"
                     /transl_table=11
                     /translation="MTDVPNGRDPNGRDPNGRRALVPASPPGMLRRLQRARLLPRSVRV
                     LRSLRVLPRSVRARSALAAAFAAAVLFTSGALLMRHQLYDERLRATSSVAQQQVTTLLS
                     ATANSSISGPWGAPYEIVAGDGMLLASSPELEPYEKDGHAFLTGPGRGGSLPLYTRRRF
                     TFPAVAEPAARSLSGQTLTTVEGTVPASYLPGETQGRGVAAGARVRVYVLIVPDDAERA
                     VGELDRELVVAVPLATALVAGVAWLATRRALRPVEAIRARTASVTAADPRERVEVPDTA
                     DEVAELALTINATLQRLEEAATAQRRFVADAAHELRSPLATLLAGLEVATAYPDRADWP
                     AVVSAAGRQARRLSGLTEELLLLARLDAGAPPAPAERVDVAALAGRLSEEYAERAGGSP
                     KVDLLVAAPDAATTVFAAPGDLERILRNLLDNALRHAVGRVLLTVARDSAAPGSVLCTV
                     RDDGAGVAEADSERIFERFTRLDESRTRTDGGTGLGLAIARDLAARHGGLLVLAVQPKG
                     SGACFVLRLPAGDPMSIRPRPFKGRGRSARSQRL"
     gene            complement(6136..6882)
                     /db_xref="GeneID:41537270"
                     /locus_tag="SAVERM_RS00795"
                     /old_locus_tag="SAV_73"
                     /old_locus_tag="SAVERM_73"
     CDS             complement(6136..6882)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537270"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525753.1"
                     /locus_tag="SAVERM_RS00795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_73"
                     /old_locus_tag="SAVERM_73"
                     /product="response regulator transcription factor"
                     /protein_id="WP_010981509.1"
                     /transl_table=11
                     /translation="MRILVVEDERELAQTLRLGLTAEGYRVDVAHDGREGLWKARTGDY
                     AVVVLDLMLPLLNGYRVCAQLRREGITTPVLVLTAKDGDWDQAEALDTGADDYVTKPFT
                     YLVLVARLRALMRRARGAASPLLAVGDLVLDVAARTCLRSGVAVPLTPREFAVAEVLAR
                     RPGEAVTKSEILHHAWPDEAEDLNLVEVRVSALRRKIDTAFGRQSLLTVRGVGYRLVDD
                     RGETEEDAVQEPPAGRWDGAGRNSGD"
     misc_feature    6916..6931
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            7056..8528
                     /db_xref="GeneID:41537271"
                     /locus_tag="SAVERM_RS00800"
                     /old_locus_tag="SAV_74"
                     /old_locus_tag="SAVERM_74"
     CDS             7056..8528
                     /codon_start=1
                     /db_xref="GeneID:41537271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005319610.1"
                     /locus_tag="SAVERM_RS00800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_74"
                     /old_locus_tag="SAVERM_74"
                     /product="DUF2079 domain-containing protein"
                     /protein_id="WP_107082910.1"
                     /transl_table=11
                     /translation="MPTRLTALLSPSRPSRPSRDDAAGPVAGTARPARGAGWATALSLA
                     LVCFVTYAALSVRLHQRMLTTGYDLGIFEQAVRSYAHGHLPVAELKGPGFPLLGDHFSP
                     VLALLAPLYRVWPAPVTLLVAQAALFAVAVIPLARWAEEVRGRRAALVVGLGYGASWGV
                     AQAVGFDFHEVCFAVPLLALSLTAVGRGRARAAALWALPLLLVKEDLGLTVAVVGLLIA
                     RTGERDDRRRGGALVLAGVLGSFLEMLVVIPAFNPGGTFAYSSSVPGAGSATPGAGELL
                     LHYTVGLVTPDTKAQTVLALLSVTGFLAVRSPLLWAALPTLLWRFASDNQAYWGTGYHY
                     SAVLMPVLFAAFVDALTRPGPVRYALAASAAVTVLLLPQFPLWQLTQPATWHTDSRLAS
                     ARRLMDRIPDGATVAASNRLVPQLTNRARVSVFGLGGSRPDAEWIIDDSAQPQGWPIAP
                     DDDRRLLSEVRNNGRYRTVADQDGYVLLQRRP"
     gene            8970..9359
                     /db_xref="GeneID:41537272"
                     /locus_tag="SAVERM_RS00810"
                     /old_locus_tag="SAV_75"
                     /old_locus_tag="SAVERM_75"
     CDS             8970..9359
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563589.1"
                     /locus_tag="SAVERM_RS00810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_75"
                     /old_locus_tag="SAVERM_75"
                     /product="RidA family protein"
                     /protein_id="WP_010981511.1"
                     /transl_table=11
                     /translation="MLTHIPPDGVAPGNGYSHVVVGEGRLVVISGQVALDEKGNVVGKG
                     DAAAQARQVFENLRRCLAAGGATFAEIAKFTFYVTDVAILPEVRAVRDAHIDTARPPAS
                     TAVQVAALYRPELMLEVEALAIIPW"
     gene            10001..11008
                     /db_xref="GeneID:41537273"
                     /locus_tag="SAVERM_RS00815"
                     /old_locus_tag="SAV_76"
                     /old_locus_tag="SAVERM_76"
     CDS             10001..11008
                     /codon_start=1
                     /db_xref="GeneID:41537273"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981512.1"
                     /locus_tag="SAVERM_RS00815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_76"
                     /old_locus_tag="SAVERM_76"
                     /product="avermitilol synthase"
                     /protein_id="WP_010981512.1"
                     /sec_met_domain="T1TS (E-value: 2.7e-75, bitscore: 253.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDIDFGLPAPAGISPGLEATRRHNLGWVRRLGLVGDGPSLAWY
                     TSWDMPRLAACGFPHARGAALDLCADAMAFFFVFDDQFDGPLGRDPARAARVCRRLTGI
                     VHGAGPGPGADACSAAFADVWARSTDGAHPGWVARTAHEWEYYFAAQAHEAINRLRGTP
                     GDMESYLQVRRGIAGTDLPLSLGERAAGITVPAAAFHSPQLRIMREAAIDVTLMCNDVY
                     SLEKEEARGDMDNLVLVIEHARRCTRDEAVTAARGEVARRVIRFEQLAREVPALCAQLG
                     LSAVERAHVDTYLGVMEAWMSGYHAWQTQTRRYTGAPHVLPSTGPGYFDEVLPT"
     gene            complement(11096..>11617)
                     /db_xref="GeneID:41537274"
                     /locus_tag="SAVERM_RS00820"
                     /old_locus_tag="SAV_77"
                     /old_locus_tag="SAVERM_77"
                     /pseudo=""
     CDS             complement(11096..>11617)
                     /codon_start=1
                     /db_xref="GeneID:41537274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823203.1"
                     /locus_tag="SAVERM_RS00820"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_77"
                     /old_locus_tag="SAVERM_77"
                     /product="methyltransferase type 11"
                     /pseudo=""
                     /transl_table=11
                     /translation="HLAGVLDQLPGARGLGLDTSVRALRSTARAHERAAAVTWVRPFPL
                     ADQLADVVLDVFAPRNPSEFHRVLRPTGRLVVVRPTGRHLAELRGQVPALVTIDPAKEQ
                     RLFTALTPFFETSRTEQVEYATFLTRTQALDLVGMTPSARHLNRADLAGNGLLPDQVTV
                     SVLATAYRPR"
     gene            complement(11644..12535)
                     /db_xref="GeneID:41537275"
                     /locus_tag="SAVERM_RS00825"
                     /pseudo=""
     CDS             complement(11644..12535)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143370.1"
                     /locus_tag="SAVERM_RS00825"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS982 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTNNLDTLATALYARIDDELKASPWLAPWRPAIGITPTLSDAELI
                     TLAVMSALLGYTSERRWLRRVGRDFGHLFPYVPQQSGYNKRLRAAFSLLTSMIRIVARD
                     TSLWSDDVWLVDSTPVGCGCSRETGRLGPVRLLRITLAILLGAASAPGVHTRRTAGPVR
                     THRGGRARNTARHARYRARRPRRSPRADDHRGQELLRPRVRARPCRASPEVAAASPQGG
                     SRADRVTPVQTAAAGHRVDQSDLQGAAQPGTTRRQEPCRSVSPGLVPDPRTHSGDLAQR
                     PNWTAHQTITHSLRSL"
     gene            complement(12621..13559)
                     /db_xref="GeneID:41537276"
                     /locus_tag="SAVERM_RS00830"
                     /old_locus_tag="SAV_79"
                     /old_locus_tag="SAVERM_79"
     CDS             complement(12621..13559)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537276"
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020552554.1"
                     /locus_tag="SAVERM_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_79"
                     /old_locus_tag="SAVERM_79"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_037652249.1"
                     /transl_table=11
                     /translation="MDVTTLYSIGELSRRTGLSVRTIRFYSDSGVVAPTTRSPAGYRLY
                     DLDALLRLELLRTLRELGMDLPTIQRVLDRELSVAEVAAAHADAMDVQIRTLQLRRSVL
                     RVVASRGSSPEETKLMHRLTQLSGEERRRLIDDFMDGTFGTVDADPAAVAMVRAATPDL
                     PDDPTGEQVTAWVELAELVGDEDFRARMRRTAVRQAAGRPLDIECDAGEELMEFTRQKV
                     AEAMEAGIDPLNDRGAPVIDDLVHRFAEVLARTPDTEFRDWMAQQFEETHDPRVDRYWQ
                     LVWIVNGWHVVPNLIPVYPWLIQALRNSRDA"
     gene            complement(<13781..14107)
                     /db_xref="GeneID:41537277"
                     /locus_tag="SAVERM_RS00835"
                     /old_locus_tag="SAV_80"
                     /old_locus_tag="SAVERM_80"
                     /pseudo=""
     CDS             complement(<13781..14107)
                     /codon_start=1
                     /db_xref="GeneID:41537277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838402.1"
                     /locus_tag="SAVERM_RS00835"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_80"
                     /old_locus_tag="SAVERM_80"
                     /product="putative RNA methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPVSLSPALEPFLDLLRCPTCRTGLHLGHGALRCPAGHTFDIARH
                     GYVSLLTGTRATSGDDAAMARARDRFLSTGSYGPIRQAVARLAADAMPEQGTVLDVGCG
                     TGYYL"
     misc_feature    complement(14152..14166)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.47"
                     /tool="antismash"
     misc_feature    complement(14224..14237)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(14350..15120)
                     /db_xref="GeneID:41537278"
                     /locus_tag="SAVERM_RS00840"
                     /old_locus_tag="SAV_81"
                     /old_locus_tag="SAVERM_81"
     CDS             complement(14350..15120)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537278"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123722.1"
                     /locus_tag="SAVERM_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_81"
                     /old_locus_tag="SAVERM_81"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_010981517.1"
                     /transl_table=11
                     /translation="MARHGGRGWYGRVLAAAVGVTALAAATSVWTAQAGPVDGQHSARP
                     AAPGSGTGRAPVSADIAHASDHGAQGVNITIDDGPDPIWTPQVLQVLRENGVKATFCMV
                     GTQAQAHPDLVKAVVAAGHRLCDHTVSHDTTMDTKSHSYQSRQILDAERMITKASGGVR
                     PLYYRAPGGAFTPYSRHLAASRGMRPLGWNADSKDFERPGADAISATVKNEIPHGPTIL
                     FHDAGGDRSQTVAALRELLPWLKQQGYSFGFPVR"
     misc_feature    complement(15378..15393)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            complement(15664..16245)
                     /db_xref="GeneID:41537279"
                     /locus_tag="SAVERM_RS00845"
                     /old_locus_tag="SAV_82"
                     /old_locus_tag="SAVERM_82"
     CDS             complement(15664..16245)
                     /codon_start=1
                     /db_xref="GeneID:41537279"
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073631.1"
                     /locus_tag="SAVERM_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_82"
                     /old_locus_tag="SAVERM_82"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_010981518.1"
                     /transl_table=11
                     /translation="MAGTGRVGLTTERLVRAGAELADEIGFEQATPAELARRFGVKTAS
                     LYSHVKNAHDLKTKIALLALEELADQVSTAVAGRAGKDALTAFANAYRDYALIHPGRFA
                     AAQFRLDPQTAAASAGVRHAQMTRAILRGYHLAEPHQTHAVRLLGSVFSGYVGLESAGG
                     FSHSAPDSKESWTEILNALDALLRSWPTAS"
     gene            16451..16669
                     /db_xref="GeneID:91294737"
                     /locus_tag="SAVERM_RS44070"
                     /old_locus_tag="SAV_83"
                     /old_locus_tag="SAVERM_83"
     CDS             16451..16669
                     /codon_start=1
                     /db_xref="GeneID:91294737"
                     /inference="COORDINATES: protein motif:HMM:NF027885.4"
                     /locus_tag="SAVERM_RS44070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_83"
                     /old_locus_tag="SAVERM_83"
                     /product="FBP domain-containing protein"
                     /protein_id="WP_010981519.1"
                     /transl_table=11
                     /translation="MTEPDGRPAGVRLCSSGGGAGAGQMCRSRCSVCVATGTGGVCLTA
                     AARSGKAGQQGSSAGICMGIDLACLLL"
     gene            complement(16867..18111)
                     /db_xref="GeneID:41537281"
                     /locus_tag="SAVERM_RS00855"
                     /old_locus_tag="SAV_84"
                     /old_locus_tag="SAVERM_84"
     CDS             complement(16867..18111)
                     /codon_start=1
                     /db_xref="GeneID:41537281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823238.1"
                     /locus_tag="SAVERM_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_84"
                     /old_locus_tag="SAVERM_84"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_010981520.1"
                     /transl_table=11
                     /translation="MATGIKDTAHAVEAAAVMRLLPARPRLLALGEPTHGEDTLLGLRN
                     ELFRQLVEQEGYRTIAIESDCLTGLAVDDYVTSGTGTLDEAMEHGFSHGWGTFAANREL
                     VRWMRAYNVRAANDGRPACERLRFAGFDGPLEITHAASPRQALTALHSYLATRVDTNLL
                     PCTATTLDHLLGTDDRWTHPAAMTDPAQSAGQSAEAGRLRLLADDLVALLDAQTPHLTT
                     ATSRDDWDRARLYGRTATGLLRYHYWMADTSPARMTRLVGLRDQMMAHNLLALAARGPA
                     LIHAHNSHLQRAKSTMRMGGIPLEWWSAGALVSARLGEEYAFVATALGTIRHQKVDTPP
                     PDTVEGLLYALPQDRCVIDAPRLATALGDTRPAPRVSPWFGYAPLDPAHLADSDGIVFV
                     KDVVQSRPRLFSKTG"
     gene            18170..18937
                     /db_xref="GeneID:41537282"
                     /locus_tag="SAVERM_RS00860"
                     /old_locus_tag="SAV_85"
                     /old_locus_tag="SAVERM_85"
     CDS             18170..18937
                     /codon_start=1
                     /db_xref="GeneID:41537282"
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979207.1"
                     /locus_tag="SAVERM_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_85"
                     /old_locus_tag="SAVERM_85"
                     /product="TioE family transcriptional regulator"
                     /protein_id="WP_010981521.1"
                     /transl_table=11
                     /translation="MGRNLQSGERLRPVDLARGHGLSTQAVRNYEEAGILPAAGRTPHG
                     YRTYTSLHAGALRAFLALVPGHGHRTAASIMRAVNEGAVDEALRLIDESHAQLLDDRRT
                     LQAVESALRDLEPTTGSGPGGGSGPAAGSGSGSGGTFIGPLAHKLGIRPATLRTWERAG
                     LVRPRRDPLTGYRVYDEADVRDARLAHQLRRGGYLLEQIAPLIARVRAAGGLEPLEAAL
                     RDWHGRLSARGRALLAGAAGLEAYLHERRKTRS"
     gene            complement(19038..20033)
                     /db_xref="GeneID:41537283"
                     /locus_tag="SAVERM_RS00865"
                     /old_locus_tag="SAV_86"
                     /old_locus_tag="SAVERM_86"
     CDS             complement(19038..20033)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:41537283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345384.1"
                     /locus_tag="SAVERM_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_86"
                     /old_locus_tag="SAVERM_86"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_010981522.1"
                     /transl_table=11
                     /translation="MLTTLGLDTAAETVYRTMLMHPQAGVAELAVHLEVPEGDVRDALD
                     MLSELALVRMSAEDAGRLRAVSPDIGMEILMARQQAELAAQQQRVEASRAAAAQLISEY
                     SELRPATRHPEVEQLVGLDQIRDRLTGLTREVSEELLTFAPGGPQTADNMAASRPLNGD
                     LLGRGVRMRTLYLDSVRTDRATVEHARWLTSLGGQVRTVPALPTRLILMDRKTALISVS
                     SDDTAAGAVVLTGQGTLTALHALFETTWAGAQPLGDTVPVDRHGLTGQQATVVRLLAEG
                     HTDETIAKRLGVSPRTARRIASELMERLEARSRFEAGVRAVQRGWLPARA"
     misc_feature    complement(20057..20070)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.27"
                     /tool="antismash"
     gene            20190..20495
                     /db_xref="GeneID:41537284"
                     /locus_tag="SAVERM_RS00870"
                     /old_locus_tag="SAV_87"
                     /old_locus_tag="SAVERM_87"
     CDS             20190..20495
                     /codon_start=1
                     /db_xref="GeneID:41537284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559452.1"
                     /locus_tag="SAVERM_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAV_87"
                     /old_locus_tag="SAVERM_87"
                     /product="hypothetical protein"
                     /protein_id="WP_037652235.1"
                     /transl_table=11
                     /translation="MYLVHIHLEFPPRTQLPFGARDMIRAALTADDLVEHVAVHPRSPS
                     RLTLGFYLLAARLEEAEERAARVSRRLAEDVPVLRGARLRGAGVPLVPLAFERTPG"
     gene            20780..20941
                     /db_xref="GeneID:51982566"
                     /locus_tag="SAVERM_RS43170"
     CDS             20780..20941
                     /codon_start=1
                     /db_xref="GeneID:51982566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119288.1"
                     /locus_tag="SAVERM_RS43170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167544187.1"
                     /transl_table=11
                     /translation="MSRTRIAQAAAVATLALAATLAAPAFASESATARVFAAGDAGWQV
                     APADAGWQ"
ORIGIN
        1 gccccggcgc acggtgcccg ttccggagca ggcgctgcgc cggatggtgg ccactgcgct
       61 gccgtccagg acgggcatcg gtgccctgct gagccagttg ctcggtgggc tcgtcgagca
      121 ggggccgaag ctggaggccg gtcagaccgg ccgggtggcg tctgccgtgg tcgatctgac
      181 caccgcgttc ctggcagggc tgagcggtgc tgacggaccg cagaccacag cggcacggcg
      241 ggtggcacaa ctgcaccaga tcaagtcgtt catccggtcc cggctcggtg agccggggct
      301 cacccccacg gccgtcgccg cggcccacca catctcgctg cgcgctttgc agtacctgtt
      361 ccgggaggac ggcaggacgg tcggcgcgtt catccgcgag cagcggctgg agcgctgccg
      421 ggccggtctc gccgaccccc gtctggccgg gcacagcgtc gccgcgatcg cggtccgtgc
      481 cggtttctgt gatgctgccg cgttcagccg ggctttcaag gcacgttacg gaatgccccc
      541 gggcgagtac cgtcggcact gcggaggacc gccgtcgcaa ggccgcgccg ggcacactgg
      601 ctgaagcccg cttccgcctc gggtggttcc gccctccccc taggaaggga ggcaccagag
      661 gggcccgtcg ccggccggcg gcggggcacg acgccccgcc ggtacggcca cgccagggtg
      721 tcggtgccag cccgccggcc gcagcgggcc caacgtcttg cgcgccgaag gtcctccacg
      781 ccgagggtct gtccgcggtt cctgtcgcac ggctggggcg catccgcggc cacctcaaca
      841 tgccagtccg cgccggatgt tcgtgctgga gccccgttag ggtccggcgg tatgaccgac
      901 cgtgttctgg aactcctgcg cacccgcccc gatctggccg aactggccgc gttccccttc
      961 ggcttcgatg tgagccgggc gtaccacgtc gaggccgtgc acctggcgtc cggtgcgccg
     1021 ctggagccga tcgccggcga cgacaccggc ggcacgtact tcctgtgcgg ggcaacggcc
     1081 gtgctccacg cgtcctccga gggcgacgcc gtgctgctcg ccgacagcgt cggcgaggcg
     1141 ctcgagatcc tcgtccggct gccctggtgg tgcgagaaca tctccgcgga gctggacgag
     1201 gaggacctgc tcgccgaagt acgtgcggcg gaccacgcag cgcgcgagga gttcgccccc
     1261 gaactggacg cgcagcgagc ggcgttgatc agcggtctgg gtctgccgga ccggccgctg
     1321 gccgaactcc ttgccatgtc gcagtcggct gccgggcgca ccgagccgga ccacgtcctg
     1381 ctcaactccc gtgagctctg cgcgtaccgg ctggaggagt ccttccgcca gcccctgcgc
     1441 gacgttgtcc ttggcccggg acgggaggtg ctggagcgga tgcgccgcgg cggtctgggc
     1501 gcgcgggagg aggcggctgg ggatccggtg ctgcgggcgg gggtgctgcg ggcggcgcag
     1561 tacgaccgcc gtgacggcga cctgccgctg ctgcgtttgc tgctggagca cgagagtgcc
     1621 gcgcggaccg agcggttcga ggagcggcgg ctggctgcgg tgctggtggc gttgcacggg
     1681 cgggaggggg acgtttcgct gctgcggtcg gccaccgggg ggcaggtcac cgacagcgcc
     1741 gaagccgtgg agtgggcccg cgccgaggag gcgaagcggt acgggcggga tgtggctgcg
     1801 gagagcgagt tcacctggat cgagctggcc cgccggcagg gtcgcatcga gcgcgcccgg
     1861 gtcgcgctca tccgcatgct ggacgacacg gggccggacg cggaccggct gcgggagctg
     1921 agccgcgcgc tggagcgcat cggcgactac gcgcaggcgg cccgcgccca gttcaacctc
     1981 ctctcgcttc aggacactgc atgggaccgg gcctcggagg cgtacgtcct ggcccgtctg
     2041 gagcgccgca ggggtgacct cgtggcagcg gggcgggcgc tggagcgggc acgggcggcg
     2101 gtcggcgccg ggggcaccac gccgggcggg gcggattgcc agtggcaccg ccgggggctc
     2161 ggccggctga tcacggagca gcatctggag ctgacgctcg ccgcggccga ggcgggtgac
     2221 gcggaactcg cgcgtgcgac gatggggcac ggcaggctcc tgctggacac ggtcggcaag
     2281 gagtcggcga aggcgctcag ccggctgtcc acgcgggcga aatgggcggt ggccgggctt
     2341 cgcccgcccg gcgcctgaca cccgcggcat catcgcccat caggacctgg cgccgttgaa
     2401 ccgcgtggcc ggcagcaagg gcggcgccgg tggcgggccc tcggtcatgc cagcaccgtc
     2461 ctggccgtcc tcgtccagtg caggtatgac gcggcgcctg caccgcggtt ggtcaggacc
     2521 tgaacctcct ggagatcctc ggcgtctccg cctgcttctc cccgggccac gacggctccc
     2581 ccacccttcc cttcgacccg cgcaccgggg ccctgcgcga gaacgagtgg cagcgctggc
     2641 tggcctggga cccggtacgg atggccacca cgcacgccga cgccctccgc tcccagcgcg
     2701 gcatctggat cgacgcgggc acccgcgacg agtggttcct cgacctgggc gcactggcct
     2761 tccgcgatgc ccttacggaa gctggagtgg ccgacgacat cgtgcatttc gagctgttcg
     2821 agggtggcca ccacgccgtc gagtaccgga tgccgcccgc ccttgcctgg ttggcgcacc
     2881 gcatcgccga tcggccttga cctcccgggt tggatcacac cccgcgaacg aatcaatacc
     2941 gccgctcagc gcacaccccg gcgagatccg ccagaacgct ctccgaagga tcaccgccgc
     3001 ggtgccggcc cttgcggagc gcgccggggc cgaggccggc ccggtgcggc ccggtgcggc
     3061 ccggtgcggc tccaaaacgt gtgttcgagg acgtccaggt ctcggtcctg acggggatgt
     3121 ccaccccgcc ggacggcacc tcctgggcgt cggggcttcg gaaggcgtca cgggagccgg
     3181 accggttcat gccccattga gccgagcggc ctgcgtacgg cgggcgaagc gttgcgggtc
     3241 acgggcgggg gcggcgtgtg gacgtgttcg tgtgaggcca gtgcctgcgg gtaagcgggc
     3301 tccaccaact cgtcagatcc ggcgtcgagc cgaccatgaa atgaggtgcc gtgtgtccgc
     3361 atcactggtg gagaccgtcg atatcgaagc ccccgtcgcc gtcacgtggg cactgtggag
     3421 cgacgtgagc cggtggccgt ccttcctgag tcacgtgcgc ctggtggagc cactggacga
     3481 gcggcgcttc gcctggcagc tgtcgctgcc gggagccgac aagaacttcg tcgccgagct
     3541 gaccgaggtg atccccgggg accgcatcgc ctggcagacc acggagggcg ttcaccatgc
     3601 gggcgttgtc accttccacc ggctcagcga cacgtcgagc cgtgtgaccc tgcagatcga
     3661 gtacgacccg aagggtttcg tcgagcacat cggggcgctc accaatttgg actccacgct
     3721 ggcgaattac gacctcggcg agttccagaa gctcgccgag acggcagccg ccggctgacc
     3781 tcccggcata cgtgtccccc acgtgacggc cttcagggcc atgtcgggag aggccatccg
     3841 cagccttctt gcggatggcc tcttcccgtc agggccgggc ggtggacgac attccgggat
     3901 ctgagggggc ccaggcatcg ttcgaggtca gatcataaga acaagctcag taacgaccga
     3961 gccaccaccg cgccgagaga gcacggcacc cgcccctccc tgcccgtcct ggaacttcac
     4021 cggcagccca ctgccggtga agtggatcca gcactcggga gagcacgcca acaccgccac
     4081 ggcaggatca tccgccgttc ccaaagcagt gaacgagaac aggctgcgct gcaccacggt
     4141 gcccggcggg aagcgttcgc ggtggcatca cgcatttggg acgacttctt cgactgcctg
     4201 cccgtgcgcg gggacacact gttcgagctg acggacgcgt tgctgtgtgc ggacgggccg
     4261 gtgaccgcgc tggtggacct gacgctgacg gccgcgcatc ggcgcgggca cggcgcgatg
     4321 tacgacgctc tcaactggtc ttgaacggat gggtcatcgt cctcccggcc cgtctgcccg
     4381 gttcggtgcc gccacggccc tccaaggcgc gggcaggcct gaatccgtcg ctcaaggggc
     4441 ccggggatcc ccgggccggg acggcagcgg tcacgcggcg cgctccttca aagtcgctgc
     4501 gacctggcgg accgcccccg acccttgaag gggcggggcc gtatcgacat cgggtctccc
     4561 gcgggcaggc ggaggacgaa gcacgccccc gaacccttcg gctgcaccgc cagcacgagc
     4621 aggccgccgt gccgggccgc caggtcgcgg gctatggcga gaccgaggcc ggtgccgccg
     4681 tccgtacggg tgcgggactc gtccaggcgg gtgaaccgct caaatatccg ttcgctgtcg
     4741 gcttccgcga cgccggcccc gtcgtcgcgg acggtgcaca gcaccgaccc gggtgcggcc
     4801 gagtcccggg ccacagtcag cagcacgcgg ccgacggcgt ggcgcagggc gttgtcgagc
     4861 aggttccgga ggatccgttc gaggtcaccg ggtgccgcga acaccgtcgt cgcggcatcc
     4921 ggcgcggcga cgaggagatc caccttcggg gaacccccgg cgcgctccgc gtactcctcc
     4981 gagagccggc ccgccagtgc cgccacgtcg acccgttcgg cgggggccgg cggggcgccc
     5041 gcgtccagcc gggccagcag gagcagttcc tccgtcagac cgctcagccg ccgcgcctgc
     5101 cggccggccg cggacaccac ggcgggccag tcggcccggt cggggtaggc ggtggccacc
     5161 tccagccccg cgagcagggt ggcgagcggg ctgcgcagtt cgtgcgcggc gtccgccacg
     5221 aaccggcgct gtgccgtggc cgcctcctcc aaccgctgga gggtggcgtt gatggtcagc
     5281 gccagttccg ccacctcgtc ggcggtgtcg ggtacctcca cccgttcgcg ggggtccgcc
     5341 gcggtcaccg aggcggtgcg cgccctgatc gcctcgaccg gccgcagcgc ccgccgcgtg
     5401 gccagccagg ccaccccggc caccagcgcg gtcgcgaggg gaacggccac gacgagttcc
     5461 cggtcgagtt cgccgaccgc ccgctcggca tcgtccggga cgatcaggac gtacacccgg
     5521 acccgggcgc cggcggccac tccgcgcccc tgcgtctcgc cgggcaggta ggaggcgggc
     5581 accgtcccct cgacggtggt cagggtctgt ccggacagcg agcgggccgc cggctcggcc
     5641 acggcgggga acgtgaaccg gcgtctggtg tacaggggca ggctcccgcc ccggcccggg
     5701 cccgtgagga acgcgtggcc gtccttctcg tacggctcca gctcgggact ggacgccagg
     5761 agcatgccgt cgccggcgac gatttcgtac ggtgctcccc aggggccgct gatggatgag
     5821 ttggcggtgg cgctgagaag ggtggtgacc tgctgctggg ccaccgacga agtggcccgc
     5881 agccgctcgt cgtacagctg atgccgcatc agcagggccc cggaggtgaa gagcacggcc
     5941 gcggcgaagg cggcggcgag cgcggaacgc gcccgcaccg agcgggggag aacccgcagc
     6001 gagcgaagaa cccgtaccga gcgtgggagt aggcgggcgc gctgaagccg gcggagcatg
     6061 ccgggcgggg acgcgggtac cagggcgcgg cgcccgttcg gatcccggcc gttcggatcc
     6121 cggccgttcg ggacgtcagt caccggagtt ccgtccggca ccgtcccacc gcccggccgg
     6181 gggctcctga acggcgtctt cctccgtctc cccgcggtcg tcgaccaacc ggtagcccac
     6241 cccgcgcacc gtcaggaggg actgccgtcc gaaggccgtg tcgatcttcc ggcgcagggc
     6301 gctgacccgg acttcgacca ggttgaggtc ctcggcctcg tccggccagg cgtggtgcag
     6361 gatctccgac ttcgtgaccg cttcgcccgg ccgccgcgcg agcacctcgg cgactgcgaa
     6421 ctcccggggc gtgagcggta cggcgacgcc cgacctgagg caggttctgg ccgccacgtc
     6481 caggaccagg tcgcccaccg ccagcagcgg ggaggccgct ccccgcgccc ggcgcatgag
     6541 cgcgcgcagc cgtgcgacca ggaccaggta ggtgaacggc ttggtgacgt agtcgtcggc
     6601 gccggtgtcg agggcctcgg cctggtccca gtcgccgtcc ttcgcggtga gcaccagcac
     6661 gggggtggtg atgccctcgc ggcgcagctg ggcgcagacc cggtagccgt tgagcagcgg
     6721 cagcatcagg tcgagcacga cgaccgcgta gtcacccgtg cgggccttcc acaggccctc
     6781 gcggccgtca tgggccacgt ccacgcgata gccctcggcc gtcagcccga ggcgcagcgt
     6841 ctgcgccagt tcgcgctcgt cctccaccac cagaatcctc accccgccag cctggcacag
     6901 gcttccggcg gctccctgac cgcttcgtca ggttcggtca gggcccggtc agcggctctc
     6961 cggcacggtg tccgggcccc ggaagggtgc ttggcgcgcc ggcccaccgc gcggcgagcg
     7021 ccgcaccggt gatccgccgg acgaaaggcc ccgacatgcc gacccgcctg accgcgctcc
     7081 tctccccgtc ccgcccgtcc cgcccgtccc gcgacgacgc ggccgggccc gtcgccggaa
     7141 cggcccggcc agcgcggggc gccggctggg cgaccgcgct gtcgctcgcc ctggtgtgct
     7201 tcgtgacgta tgcggcgctg tccgtgcggc tgcaccagcg gatgctgacc accggctacg
     7261 acctggggat cttcgagcag gcggtacggt cctacgcgca cgggcacctg ccggtggccg
     7321 agctcaaggg accggggttc ccgctgctcg gcgaccactt ctcgcccgtg ctggccctgc
     7381 tggcaccgct gtaccgggtc tggccggcgc cggtgaccct gctggtggcg caggccgcgt
     7441 tgttcgcggt ggcggtgata cccctggcca ggtgggccga ggaggtacgc ggccggcggg
     7501 cggcgctggt ggtcggtctc ggctacggcg cctcctgggg ggtcgcacag gcggtcgggt
     7561 tcgacttcca cgaggtgtgc ttcgcggtgc cgttgctggc gttgtccctg acggcggtgg
     7621 gccgtggccg ggcgcgtgcc gcggccctgt gggcgcttcc gctgctgctg gtgaaggagg
     7681 atctcgggct gaccgtcgcg gtcgtgggtc tgctgatcgc gcgcaccggc gagcgcgacg
     7741 accgcaggag ggggggtgcc ctggtcctgg ccggagtgct cgggtccttc ctggagatgc
     7801 tggtcgtgat accggcgttc aaccccggcg gcacgttcgc gtacagctcc agcgtgcccg
     7861 gcgcggggtc cgccaccccg ggcgccggcg agttgctcct ccactacacg gtgggactgg
     7921 tcaccccgga caccaaggcg cagacggtgc tggccctgct gtccgtgacc gggttcctgg
     7981 ccgtgcgctc cccgctcctg tgggcggccc tgccgacgct cctgtggcgc ttcgcgtcgg
     8041 acaaccaggc ctactgggga accggctacc actacagcgc ggtcctgatg ccggtgctgt
     8101 tcgccgcctt cgtcgacgcg ctgacccggc ccggaccggt gcggtacgcg ctggcggcga
     8161 gcgcggccgt cacggtgctc ctgctgcccc agttcccgct gtggcagctg acgcagcccg
     8221 ccacctggca caccgactcc cggctcgcgt ccgcccggcg gctgatggac cgcatcccgg
     8281 acggcgccac cgtcgccgcc tccaaccggc tggtcccgca gctcaccaac cgcgcccggg
     8341 tcagcgtgtt cggcctgggg ggcagccgtc ccgacgcgga gtggatcatc gacgacagcg
     8401 cgcagccgca gggctggccg attgcacccg acgacgaccg caggctgctg tccgaggtcc
     8461 ggaacaacgg ccgctaccgg accgtcgcgg accaggacgg ctacgttctc ctgcagcggc
     8521 ggccctgaca gagccgcagg ccggcgacgc cgtggagctc gtggcgcctc ctacgcctgt
     8581 cctacgcctg cgcccgcccc tgttcccgta cctgggcgag ccgttggacg ccgaggccga
     8641 gggccgtccg gtggcgtccg ccgggaaggt gccgggggcg ccggcggtga ggacgatcgc
     8701 ggagcagccc ggcagcccgc tgggctcatg acgcgttctc cggccacagt ccccaccccg
     8761 gggctgcggc ggtgcccggg cttcgctcga agatcacctc ttgccgggcc gttcaccgac
     8821 tgtacgtagc tgagacgcgg cgtgtgctgg gctcccacgg cccaacacac gccgggatgg
     8881 acagagttgg tgccgtatac cgtggcctcg tcacctgtcg tccgaggagt tcacctgtgc
     8941 cagatgagac agacgagtca gaagagacca tgctcaccca cattccgcca gacggggtcg
     9001 ccccggggaa cggctacagc catgtggttg tgggcgaagg ccgactggtc gtcatctccg
     9061 ggcaggtcgc actggacgaa aagggaaatg tggtcgggaa aggcgacgcc gccgcccagg
     9121 cccgtcaggt cttcgagaac ctgcggcgct gcctcgcggc aggcggcgca acgttcgccg
     9181 agatcgccaa gttcaccttc tacgtcaccg acgtcgccat actgccggag gtacgggccg
     9241 tccgcgacgc gcacatcgac accgcgcgtc cgcctgccag taccgcagta caggtcgccg
     9301 ccctgtaccg gccggagctc atgctggagg tagaagccct cgccatcatc ccctggtgac
     9361 tcggcaagcc tgtggccggg cggtgggacg ggttgctcat gaccttcgag tgaacccgcc
     9421 gcggcccggg catcaccgca gctcagggat tgcggcgagc ggcatcacgc gaagaatctc
     9481 agcaggatca ccgatggacg ggggcgggct cgctttgtga acgcgcggtt cgaacggacg
     9541 gcggccggct gccgccaggc cctcagcctc accgcccgga ccctcactgc cccgccgcgc
     9601 agccgcgttc tcccggccca aagagcagac gtccggccgg ggaagggaat tcaccagctt
     9661 ctgagcagga tccaccgggc ttcatcaggc cggccgggca ccggcaaccg tccgctcctg
     9721 tcctggcgtt gtacggagtc cggcggcggc gcgcgggcag acgcagccgg ccgggcggcc
     9781 tgaccgtcac ccctcaggcg cggagatctt gggcgctggg cgccaccggg ccgagaaggc
     9841 cgcaattgcc gcccggactg aaggccggga tcccttgcga agaacaaggg atgggagtgc
     9901 tctgtgcggt gaggggcgag ggcgccgccg ggcgggtcgg cctcaccccc tcgcagggcg
     9961 ccggcacgcg ccgtcgcggc ccacgacgcc gggaggtccc atgccccagg acatcgactt
    10021 cggcctcccc gcgcccgcgg ggatcagccc cggcctcgag gccacacgcc ggcacaacct
    10081 cggctgggtg cgccgtctgg gtttggtcgg cgacggaccg tccctcgcct ggtacacctc
    10141 ctgggacatg ccgcgtctgg ccgcctgcgg cttcccccac gcccggggcg ccgcgttgga
    10201 cctgtgcgcg gatgcgatgg cgttcttctt cgtcttcgac gaccagttcg acggccctct
    10261 cggccgggat ccggcccggg ctgcccgcgt ctgccggcgg ctgaccggca tcgttcacgg
    10321 cgccggccca gggcctggag cggacgcgtg ctcggcggcg ttcgccgacg tgtgggcccg
    10381 cagcaccgac ggcgcccacc cgggctgggt ggcgcgtacc gcgcacgagt gggagtacta
    10441 cttcgccgcc caggcccacg aggcgatcaa ccggctccgc ggcacccccg gcgacatgga
    10501 gtcctacctt caggtccgcc ggggcatcgc cggcaccgat ctgcctctct ccctgggcga
    10561 gagagccgcc gggatcaccg tcccggcggc cgcgttccac agcccgcagc tgcggatcat
    10621 gcgggaagcg gccatcgacg tcaccttgat gtgcaacgac gtgtactccc tcgaaaagga
    10681 ggaagcacgc ggtgacatgg acaacctcgt cctcgtcatc gaacacgccc ggcgctgcac
    10741 ccgcgacgaa gccgtcaccg cggcccgcgg ggaagtcgcc cggcgtgtca tccggttcga
    10801 gcagctggcc cgggaggtac ccgccctgtg cgcccagctc gggctgagcg ccgtggagcg
    10861 ggcccacgtc gacacctacc tgggtgtcat ggaggcctgg atgagcggat accacgcctg
    10921 gcagacccag acacggcgct acaccggcgc gccacacgtc ctgcccagca ccggccccgg
    10981 gtacttcgac gaggtcctgc ccacgtgaag tgctctccgg gccgcccgcc ggccgtcgtg
    11041 gtcacccggg gcgcccactg tccgccggtc ggcaggcggg tgcgcccgct cagggtcacc
    11101 ggggccggta tgcggtggcc agcacggaga cggtgacctg gtcgggcagg aggccgtttc
    11161 cggccaggtc tgcacggttc aggtggcgtg cgctgggcgt catccccacc aggtcgaggg
    11221 cctgcgtcct ggtcaagaac gtggcgtact cgacctgttc ggtacgggag gtctcgaaga
    11281 agggggtcag agccgtgaac aggcgctgtt ccttggccgg gtcgatcgtg accagcgcgg
    11341 ggacctggcc gcgcagttcg gccaggtgcc gtccggtagg gcgcaccacg accagccggc
    11401 cggtcgggcg cagcacccgg tggaactcgg atgggttgcg gggggcgaac acgtccagca
    11461 cgacgtcggc cagctggtcg gccagcggga agggacggac ccaggtcacc gctgcggctc
    11521 gctcatgggc tcgggcggtg gagcgcagcg cgcgcaccga ggtgtccagg cccagaccac
    11581 gggcgccggg caactggtcg aggacgccgg ctagatgaat gagtccaagg ggtgttgttg
    11641 cggtcagtga ccgtaggctg tgagtgatcg tttgatgggc tgtccagttt ggtcgttgtg
    11701 ccagatcgcc gctgtgagtg cgaggatccg gcacaagacc cgggctgaca ctcctgcagg
    11761 gctcttgccg ccgtgtcgtt ccaggttgag ctgccccttg aaggtctgat tgatcgactc
    11821 gatgacctgc cgcagcggtt tgaacaggtg tgacccggtc agctcggctt cccccttgcg
    11881 ggctggccgc agcaacttca ggtgacgctc ggcaaggccg cgctcgaact cgcggccgaa
    11941 gtagttcttg tccccgatga tcgtctgccc ggggtgagcg gcgaggacgt ctggcgcggt
    12001 atcgagcatg tcgcgcagtg tttcgcgctc gtccgccccg gtgagtgcga acaggaccgg
    12061 cagtccgccg agtgtgcaca ccaggtgcag acgcagcccc cagaagtatc gcgagtgtga
    12121 tgcgcagtag ccgtactggg cccagcctgc cagtctcacg ggagcaaccg cagccgaccg
    12181 gtgtggagtc gaccagccac acatcgtcgc tccacagtga ggtatcgcgg gccacgatcc
    12241 ggatcatgct ggtgagcagt gagaacgcgg cgcgcagccg cttgttgtag ccggactgct
    12301 ggggcacgta gggaaacagg tggccgaagt cccgcccgac gcggcgaagc cagcgccgct
    12361 cagaggtgta tccgagcagc gccgacatga ccgcgagcgt gatcagctcg gcgtcactga
    12421 gtgtgggcgt gattccgatg gcaggccgcc acggcgccag ccacggtgaa gccttcaact
    12481 cgtcgtcaat ccgggcatag agtgccgttg cgagggtgtc caggttgtta gtcacacatc
    12541 gacgttggac gccctcgcct catgtccgca ggtgatcctc tggactcatt cagggatccg
    12601 gggcgtgccc actgcggtga ctatgcgtca cggctatttc gcagggcctg gatgagccag
    12661 gggtacaccg ggatcaggtt cggtactacg tgccagccgt tgacgatcca taccagctgc
    12721 cagtatcggt ctacccgggg atcgtgcgtc tcttcgaact gctgggccat ccagtcccgg
    12781 aattccgtgt caggggtgcg cgcgagcacc tcggcgaagc ggtgcacgag gtcgtcgatg
    12841 acgggtgcgc ccctgtcgtt gagcgggtcg atgcccgcct ccatggcctc ggccaccttc
    12901 tgacgggtga actccatcag ttcctcgccg gcatcgcatt cgatgtcgag cgggcgcccg
    12961 gccgcctgac gtacggccgt ccggcgcatc cgggcacgga aatcctcgtc gccgaccagc
    13021 tcggcgagct ccacccacgc ggtgacctgc tcgccggtcg gatcatcggg gaggtcggga
    13081 gtggcagcgc gaaccatggc caccgcggct gggtcggcat ccactgtgcc gaaggtgcca
    13141 tccatgaaat cgtcgatcag acggcggcgt tcctcgccgg acaactgcgt gagcctgtgc
    13201 atgagcttgg tctcctcggg actggacccg cggctggcca cgactcgcag aacgctccga
    13261 cgcagttgca gcgtccggat ctggacgtcc atggcgtcgg cgtgcgccgc ggcgacttcc
    13321 gccaccgaga gctcacggtc cagtacccgt tgaatcgtgg gcaggtccat gcccagctcg
    13381 cgcagtgtgc gcaggagttc cagacggagc agtgcgtcga ggtcgtagag ccggtaaccg
    13441 gcgggactac gggtggtcgg cgctaccacc cccgaatcgg agtagaaccg gatggtcctc
    13501 acagacaagc cggtccgccg ggaaagctcc ccgatcgagt agagggtcgt aacgtccatg
    13561 tcccccactc tgctgtctcc agtcagtgga gactcaaggc cattccccag ccgggccccg
    13621 acccagacgt ccaccgagtc gctgaagcat gcgtcgcgtg ctctccgctg accgccaaaa
    13681 tgaaacgggc acgccttgca cgtgctgggc gggcgatggc agcgacatgc gacgccactc
    13741 gctggcggcc tacgactacg agcccttgga ctcaatcatc taggtagtag cccgtgccgc
    13801 accccacgtc caggaccgtg ccctgctcgg gcatcgcgtc ggccgccagg cgggccacgg
    13861 cttggcggat gggcccgtag ctgccggtgg acaggaaccg gtcccgggcc cgggccatgg
    13921 ccgcatcgtc gccgctggtg gcgcgggtgc ccgtcagaag gctgacgtag ccgtggcggg
    13981 cgatatcgaa ggtgtggccg gccgggcagc gcagtgcgcc gtggccgagg tggagaccgg
    14041 tgcggcacgt tgggcagcgc aggaggtcga ggaacggttc gagggcaggg gacagcgaca
    14101 cgggcacaag gcactcctgg caacggtgaa agggagaggt ctgtgcctgc acgtgttcag
    14161 aaaaacgccg tcccaagggg gaacgggccc ggcatccggc cgcctcggta acgggcagct
    14221 ccgggaacgt aagttcacgc agcaggcaca ccaaggaggg cgacgccgtc cggcatcgcc
    14281 ctcggcctcc cggtcagagg aagcagtagt gcggggtgct cgtgaacgtc acaccgcgat
    14341 tctacgattt cagcgcactg ggaagccgaa ggaatatccc tgctgcttca gccacggcag
    14401 gagctcgcgc agggcggcca cggtctggga gcggtccccg ccggcgtcgt ggaagagaat
    14461 ggtcgggccg tggggtatct cgttcttgac ggtggcgctg atggcgtcgg cgccggggcg
    14521 ctcgaagtcc ttggagtcgg cgttccagcc cagcggccgc atcccccggg aggccgcgag
    14581 gtgccggctg tagggggtga aggcaccgcc cggggccctg tagtacagcg gccggacgcc
    14641 tccggaggct ttggtgatca tgcgttcggc gtccaggatc tgtcgtgact ggtacgagtg
    14701 ggacttggtg tccatggtgg tgtcgtgcga gaccgtgtgg tcacacagcc ggtgcccggc
    14761 cgccaccacc gccttgacca ggtccgggtg agcctgggcc tgtgtgccca ccatgcagaa
    14821 ggtggccttc acgccgttct cccgcagcac ttgcagcacc tgcggtgtcc agatggggtc
    14881 cggtccgtcg tcgatggtga tgttgacgcc ttgggcgccg tggtccgagg cgtgggcgat
    14941 gtccgccgac accggcgccc ggccggtgcc ggaacccggt gcggcggggc gcgcggagtg
    15001 ctgcccgtcg acgggaccgg cctgtgcggt ccataccgag gtagcggctg ccagcgccgt
    15061 caccccgacc gccgccgcaa gtacccggcc gtaccatccc cgcccgccat gccgcgccat
    15121 gtcagccctg ttccttgtcg tcgtggtgga ttccgtgcac ccgtcaggac ggagaaacgg
    15181 ccccgcgaga tccctctgtt gctgatcacg gacaattccg caggggtttc gagacgcgtg
    15241 agcgtccgcg tcgggagccg gtgagttcgt tgaccagcgg tatcgggccg gcggtgcctg
    15301 tccggacgga cgcgtacgcc atcaactcgc ggcccccgcc gcgtgtttca cctggccggt
    15361 gggctccacc ggcaacatcg accagacctt cagcgtcgac ggctcgctgc tccagtcgga
    15421 aatcgttgcc tgagctggcc ggcttcgttg ttccgggcat ggcaaagtgg ccgaagccgg
    15481 ttggtgggac tgggagttgg agtcggtgtt cgcacgggtt gcgggccggt tcgcggggtg
    15541 gatctgcggt ggcggacgcg ggaccaggcg cgcggtctgc ggtcgggtgc ggtccgtccg
    15601 actcgcctgc gccaggcggt agttcacacc gcttcgcgca ggtcatcgga ttcctcgggt
    15661 gggtcaggag gcggtgggcc agctgcgcag cagggcgtcg agtgcgttga ggatctcggt
    15721 ccagctctcc ttggagtcgg gggcgctgtg gctgaagccg ccggcgctct ccaggccgac
    15781 gtagccgctg aagacactgc ccagcagccg caccgcgtgt gtctggtgcg gttcggccag
    15841 gtggtagccg cgcaggatcg cccgcgtcat ctgggcgtgc cggacgccgg cgctggcggc
    15901 cgccgtctgc gggtcgagcc ggaactgggc tgcggcgaag cgtcccgggt ggatgagggc
    15961 gtagtcgcgg taggcgttcg cgaaggcggt cagggcgtct ttgccggccc gtcctgccac
    16021 cgcggtggag acctggtcgg cgagttcctc cagggcgagc agggcgatct tggtcttgag
    16081 gtcgtgggcg ttcttcacgt gcgagtacag gctcgcggtc ttgacgccga accgccgggc
    16141 gagttccgcg ggggtcgcct gctcgaagcc gatctcgtcg gcgagttctg ctcctgcccg
    16201 gaccaggcgc tccgtggtca gtcctacccg tccggtccct gccatgctca tcctccgaat
    16261 tgcttcccat ctctggcatc gacgattatg cacttgccta atcgaattag gtctgcgcca
    16321 agggatgggg ccaggcgtct ggccgtcccc cgtgaccggc cgggcagtgc ctcggcggtc
    16381 tggacttcct gggcaggtga gatccccggg cctggccttt gaccgggcct gcctttgacc
    16441 gggcctgcct gtgaccgagc cggacggccg cccggccggt gtccggctgt gctcctccgg
    16501 cggcggcgcc ggcgccgggc agatgtgccg cagcaggtgc tcggtgtgcg tggccaccgg
    16561 caccgggggc gtctgcctga cggccgcggc gaggtccggg aaggccgggc agcagggcag
    16621 ctcggccggc atctgcatgg gcatcgatct ggcctgcctg ctcctgtagg cacgcgggaa
    16681 ggaggacgcg ggcaccggcg cacgcctgcg cacgagtccc tcaccctgga ggagaaggtc
    16741 cagccggccg tggcggacct cgccgcgtca tcgcccaggt gaccgcggcc gggggccgcc
    16801 tcccgctcca gcccccctcc ccccggtatc gcggtcagcg acacctttct gccgtcaggt
    16861 gtcggttcag ccggttttgc tgaacagccg gggccggctc tgcacgacgt ccttgacgaa
    16921 cacgatgccg tcgctgtccg ccaggtgggc cgggtcgagc ggggcgtagc cgaaccaggg
    16981 ggatacgcgg ggcgcgggcc gcgtgtcgcc gagggcggtg gccagccgcg gggcgtcgat
    17041 gacgcagcgg tcctgcggga gcgcgtacag gagtccttcg acggtgtccg gcggcggggt
    17101 gtccactttc tggtggcgga tcgtgccgag ggcggtggcc acgaaggcat actcctcgcc
    17161 gagccgggcg ctcaccagcg caccggcgct ccaccactcc agcggtatcc cgcccatgcg
    17221 catcgtgctc ttggcccgct ggagatggga gttgtgggcg tggatgagtg ccgggccccg
    17281 ggcggcgagg gcgaggaggt tgtgggccat catctggtcc cgcaggccca ccagccgggt
    17341 catgcgggcc ggtgaggtgt cggccatcca gtagtggtag cgcagcaggc cggtcgcggt
    17401 gcgcccgtac aggcgtgccc ggtcccagtc gtcccgcgag gtcgccgtgg tcaggtgcgg
    17461 cgtctgtgcg tcgagcagcg ccaccagatc gtcggcgagc agccgcagcc ggccggcctc
    17521 ggccgactgc cccgcggact gggccgggtc cgtcatcgcg gcgggatggg tccaccggtc
    17581 gtcggtgccg agcaggtggt cgagtgtggt tgcggtgcag gggagcaggt ttgtgtccac
    17641 ccgggtcgcg aggtagctgt ggagtgcggt gagggcctgc cgggggctcg cggcgtgggt
    17701 gatctccagc gggccgtcga agccggcgaa gcggagccgc tcgcaggcgg gccggccgtc
    17761 gttggcggca cggacattgt aggcgcgcat ccagcgcacg agttcgcggt tggccgcaaa
    17821 ggtgccccag ccgtggctga atccgtgttc catggcctcg tcgagagtgc cggtgcccga
    17881 ggtgacgtag tcgtccacgg ccaggcccgt caggcagtcg ctctcgatcg cgatcgtccg
    17941 gtagccctcc tgctcgacga gctgccggaa gagttcgttg cgcaggccga ggagagtgtc
    18001 ctcgccgtgg gtgggctcgc ccagggcgag cagccggggc cgggccggga gcagcctcat
    18061 gacggcggcg gcctcaacag catgggcggt gtccttgatg ccagtagcca tgccttcgac
    18121 ggtatcgttg aagcttcggt tgaaactttt ccgcgatatc ggcaggttca tggggcgaaa
    18181 ccttcaaagc ggtgagcggc tcaggccggt tgatctggcg cgtgggcacg gtctgtccac
    18241 gcaggcggtc aggaattacg aggaggccgg catccttccg gccgccggcc gcacacccca
    18301 cggctaccgc acctatacct cgctgcacgc gggggccctg cgcgcgtttc ttgcgctggt
    18361 gcccggccac ggccaccgga cggcggcgtc gatcatgcgg gcggtgaacg agggcgcggt
    18421 cgatgaggcg ttgcgcctca tcgacgagag ccacgcccag ctcctcgacg accggcggac
    18481 cctccaggcc gtggagagcg ccctgcgcga cctggagccc accacggggt ccgggcccgg
    18541 tggggggtcc gggccggccg cggggtccgg gtccgggtcc ggcggcacgt tcatcgggcc
    18601 gctggcacac aagctcggga tccggcccgc gacgctgcgc acatgggaac gcgccgggct
    18661 ggtgcgcccg cgccgcgacc cgctgacggg gtaccgcgtc tacgacgagg ccgacgtacg
    18721 ggacgcccgg ctggcccacc agctcaggcg gggcggctac ctgctggagc agatcgcccc
    18781 gctgatcgcc cgggtgcggg cggccggcgg cctggagccg ctggaggccg ccctgcgcga
    18841 ctggcacggc cggctgtccg cccgcgggcg ggcgctgctg gccggggccg ccgggctgga
    18901 ggcgtacctc cacgagcgca ggaaaaccag gtcctgacct gcgtcttcaa ggttgaaaaa
    18961 cacctgctcg gcttgttctt ggccttccgg tgctgaacgg tgcctcgcct ccaggtgtcc
    19021 tggctccagg tgaagcccta ggcccgcgcg ggcagccagc cgcgctggac ggcccgtacg
    19081 cccgcctcga agcggctgcg ggcctccagg cgttccatga gttcggaggc gatgcggcgg
    19141 gccgtgcggg gcgagacgcc caggcgcttg gcgatcgtct cgtcggtgtg gccctcggcg
    19201 aggaggcgta cgacggtggc ctgctggccg gtgagaccgt gccggtccac ggggacggtg
    19261 tcccccagcg gctgcgcgcc agcccacgtc gtctcgaaca gggcgtgcag cgcggtcagc
    19321 gtgccctgtc cggtgaggac caccgctccg gccgcggtgt cgtcgctgct gaccgagatc
    19381 agcgcggtct tgcggtccat gaggatcagc cgggtgggca gggcgggcac ggtgcgcacc
    19441 tggccgccca gggacgtgag ccatctggcg tgttcgacgg tggcccggtc ggtgcgcacg
    19501 ctgtcgaggt agagcgtgcg catgcgcacc ccgcggccga ggaggtcccc gttgagcggc
    19561 cgggacgcgg ccatgttgtc cgcggtctgc gggccgcccg gggcgaaggt gagcagctcc
    19621 tcgctcacct cgcgcgtgag accggtgagc cggtcgcgta tctggtccag gcccaccagt
    19681 tgttccacct cggggtggcg ggtggccggg cgcagctcgg agtactcgga gatcagctgg
    19741 gccgcggctg cccgcgaggc ctccacgcgc tgctgctgcg cggcgagttc ggcctgctgg
    19801 cgtgccatca ggatctccat gccgatgtcg ggcgagaccg cgcgcagccg ccccgcgtcc
    19861 tcggcggaca tccgcacgag cgccagttcg ctcagcatgt cgagtgcgtc gcgtacgtcc
    19921 ccctccggta cctccaggtg tacggcgagt tcggcgacgc ccgcctgcgg atgcatcagc
    19981 atcgtgcggt agaccgtctc agcggccgtg tccagaccca gtgtggtcag cattggtaac
    20041 cccccagttc ccatggcttt tgccaaaaag cgaaacgatc tttccagact gttgccggtt
    20101 acgacagacg gtggacggaa caggccacgg acggaacagg ccaaagcgga cggccgtggt
    20161 gggtgcccgt gtgctgggac ggtagaggca tgtacctcgt ccacatccat ctggagtttc
    20221 cgccccggac ccaactcccc ttcggagcac gggacatgat ccgggcggcc ctcacggcgg
    20281 acgacctcgt cgagcacgtg gccgtgcatc cccggtcgcc gtcccggctc accctcggct
    20341 tctatctgct cgccgcccgc ctggaggagg cggaggagag agccgcacgg gtgagccgcc
    20401 ggctggcgga agacgttccc gtcctgcgcg gggcccggct gcgcggcgcg ggggtcccgc
    20461 tcgtgccgct ggcgttcgag cggacgccgg gctgatcaag ccggtggact gatcgggccg
    20521 ccggacaggg ccgggccggg agggccgccg gggccgggag ggcggccggt cgggcccggg
    20581 tcgtggccgt ggccgtggcc gccggccggg gccggtgtgg acgcatccgt ccaaggcccc
    20641 ttccgtccac cggccacccc ttcccgcccg cctgacctgc ggcgaagcta tgaatcaccg
    20701 gccgggacac gcaccaccgc ggggtgtggg aacgggccgg agccgcctca tagttgacgc
    20761 cggaaggacc cgaacagtca tgagccgcac tcgtatcgcc caggccgccg cggtcgccac
    20821 cctcgccctc gcggccaccc tcgccgctcc ggccttcgcg tccgagtccg caacggcccg
    20881 ggtctttgcc gccggcgacg cgggctggca ggtcgccccc gccgacgccg gctggcagtg
    20941 agcggccccc cgcacccgcc tgtggccctg ctgctccccg tgagcggcag ggccacaggc
    21001 gggtgcgg
//
